Редактирование: ASB7

Ankyrin repeat and SOCS box protein 7 (ASB-7)

==Publications==

{{medline-entry
|title=[[ASB7]] Is a Novel Regulator of Cytoskeletal Organization During Oocyte Maturation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33251222
|abstract=Ankyrin repeat and SOCS box (ASB) family members have a [i]C[/i]-terminal SOCS box and an [i]N[/i]-terminal ankyrin-related sequence of variable repeats. To date, the roles of ASB family members remain largely unknown. In the present study, by employing knockdown analysis, we investigated the effects of [[ASB7]] on mouse oocyte meiosis. We show that specific depletion of [[ASB7]] disrupts maturational progression and meiotic apparatus. In particular, abnormal spindle, misaligned chromosomes, and loss of cortical actin cap are frequently observed in [[ASB7]]-abated oocytes. Consistent with this observation, incidence of aneuploidy is increased in these oocytes. Meanwhile, confocal scanning reveals that loss of [[ASB7]] impairs kinetochore-microtubule interaction and provokes the spindle assembly checkpoint during oocyte meiosis. Furthermore, we find a significant reduction of [[ASB7]] protein in oocytes from aged mice. Importantly, increasing [[ASB7]] expression is capable of partially rescuing the maternal age-induced meiotic defects in oocytes. Together, our data identify [[ASB7]] as a novel player in regulating cytoskeletal organization and discover the potential effects of [[ASB7]] on quality control of aging oocytes.

|keywords=* ASBs
* maternal aging
* meiosis
* oocyte
* reproduction
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674779
}}
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