Редактирование: ADCY6

Adenylate cyclase type 6 (EC 4.6.1.1) (ATP pyrophosphate-lyase 6) (Adenylate cyclase type VI) (Adenylyl cyclase 6) (Ca(2 )-inhibitable adenylyl cyclase) [KIAA0422]

==Publications==

{{medline-entry
|title=Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23020224
|abstract=β-adrenoceptors are the common pharmacological targets for the treatment of cardiovascular diseases and asthma. Genetic modifications of β-adrenergic system in engineered mice affect their lifespan. Here, we tested whether genes encoding for key components of the β-adrenergic signaling pathway are associated with human longevity. We performed a 10-year follow-up study of the Chinese longitudinal healthy longevity survey. The Han Chinese population in this study consisted of 963 long-lived and 1028 geography-matched young individuals. Sixteen SNPs from [[ADRB1]], [[ADRB2]], [[ADCY5]], [[ADCY6]], and [[MAPK1]] were selected and genotyped. Two SNPs, rs1042718 (C/A) and rs1042719 (G/C), of [[ADRB2]] in linkage disequilibrium (D' = 1.0; r2 = 0.67) were found to be associated with enhanced longevity in men in two geographically isolated populations. Bonferroni-corrected P-values in a combined analysis were 0.00053-0.010. Men with haplotype A-C showed an increased probability to become centenarians (the frequency of A-C in long-lived and young individuals are 0.332 and 0.250, respectively, OR = 1.49, CI 95% = 1.17-1.88, P = 0.0007), in contrast to those with haplotype C-G (the frequency of C-G in long-lived and young individuals are 0.523 and 0.635, respectively, OR = 0.63, CI 95% = 0.51-0.78, P = 0.000018). The permuted P-values were 0.00005 and 0.0009, respectively. [[ADRB2]] encodes the β2-adrenergic receptor; the haplotype A-C markedly reduced its translational efficiency compared with C-G (P = 0.002) in transfected HEK293 cells. Thus, our data indicate that enhanced production of β2-adrenergic receptors caused by genetic variants is inversely associated with human lifespan.
|mesh-terms=* Adenylyl Cyclases
* Aged, 80 and over
* Aging
* Asian Continental Ancestry Group
* Case-Control Studies
* Female
* Follow-Up Studies
* Genes, Reporter
* HEK293 Cells
* Haplotypes
* Humans
* Linkage Disequilibrium
* Longevity
* Luciferases, Renilla
* Male
* Mitogen-Activated Protein Kinase 1
* Polymorphism, Single Nucleotide
* Protein Biosynthesis
* Receptors, Adrenergic, beta-1
* Receptors, Adrenergic, beta-2
* Surveys and Questionnaires
* Transfection

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633790
}}