Редактирование: ACAD9

Complex I assembly factor ACAD9, mitochondrial precursor (Acyl-CoA dehydrogenase family member 9) (EC 1.3.8.-) (ACAD-9)

==Publications==

{{medline-entry
|title=Identification of a novel mitochondrial complex I assembly factor ACDH-12 in Caenorhabditis elegans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29540318
|abstract=Assembly of complex I of the mitochondrial respiratory chain (MRC) requires not only structural subunits for electron transport, but also assembly factors. In the nematode Caenorhabditis elegans, NUAF-1 and NUAF-3 are the only two assembly factors that have been characterized. In this study, we identify ACDH-12 as an assembly factor of the respiratory complex I. We demonstrate for the first time that a deficiency of ACDH-12 affects the formation and function of complex I. RNAi knockdown of acdh-12 also shortens lifespan and decreases fecundity. Although ACDH-12 has long been recognized as a very long-chain acyl-CoA dehydrogenase (VLCAD), the knockdown nematodes did not exhibit any change in body fat content. We suggested that in Caenorhabditis elegans, ACDH-12 is required for the assembly of the respiratory complex I, but may not be crucial to fatty acid oxidation. Interestingly, sequence analysis shows high homology between ACDH-12 and the human [[ACAD9]], a protein that has initially been identified as a VLCAD, but later found to also be involved in the assembly of complex I in human.
|mesh-terms=* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Electron Transport Complex I
* Fertility
* Gene Knockdown Techniques
* Longevity
* Mitochondria
* Mitochondrial Proteins
* Protein Multimerization
|keywords=* ACAD9
* ACDH-12
* C. elegans
* Complex I assembly factor
* Very long-chain acyl-CoA dehydrogenase
|full-text-url=https://sci-hub.do/10.1016/j.mito.2018.02.010
}}