Редактирование: ABLIM3

Actin-binding LIM protein 3 (abLIM-3) (Actin-binding LIM protein family member 3) [KIAA0843] [HMFN1661]

==Publications==

{{medline-entry
|title=Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29529016
|abstract=Memories become less precise and generalized over time as memory traces reorganize in hippocampal-cortical networks. Increased time-dependent loss of memory precision is characterized by an overgeneralization of fear in individuals with post-traumatic stress disorder (PTSD) or age-related cognitive impairments. In the hippocampal dentate gyrus (DG), memories are thought to be encoded by so-called 'engram-bearing' dentate granule cells (eDGCs). Here we show, using rodents, that contextual fear conditioning increases connectivity between eDGCs and inhibitory interneurons (INs) in the downstream hippocampal [[CA3]] region. We identify actin-binding LIM protein 3 ([[ABLIM3]]) as a mossy-fiber-terminal-localized cytoskeletal factor whose levels decrease after learning. Downregulation of [[ABLIM3]] expression in DGCs was sufficient to increase connectivity with [[CA3]] stratum lucidum INs (SLINs), promote parvalbumin (PV)-expressing SLIN activation, enhance feedforward inhibition onto [[CA3]] and maintain a fear memory engram in the DG over time. Furthermore, downregulation of [[ABLIM3]] expression in DGCs conferred conditioned context-specific reactivation of memory traces in hippocampal-cortical and amygdalar networks and decreased fear memory generalization at remote (i.e., distal) time points. Consistent with the observation of age-related hyperactivity of [[CA3]], learning failed to increase DGC-SLIN connectivity in 17-month-old mice, whereas downregulation of [[ABLIM3]] expression was sufficient to restore DGC-SLIN connectivity, increase PV  SLIN activation and improve the precision of remote memories. These studies exemplify a connectivity-based strategy that targets a molecular brake of feedforward inhibition in DG-[[CA3]] and may be harnessed to decrease time-dependent memory generalization in individuals with PTSD and improve memory precision in aging individuals.
|mesh-terms=* Aging
* Amygdala
* Animals
* CA3 Region, Hippocampal
* Dentate Gyrus
* Down-Regulation
* Excitatory Postsynaptic Potentials
* Fear
* Female
* Generalization, Response
* HEK293 Cells
* Humans
* Interneurons
* LIM Domain Proteins
* Memory, Long-Term
* Mice, Inbred C57BL
* Microfilament Proteins
* Neural Inhibition

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893385
}}