Редактирование: ABCA2

ATP-binding cassette sub-family A member 2 (EC 7.6.2.-) (ATP-binding cassette transporter 2) (ATP-binding cassette 2) [ABC2] [KIAA1062]

==Publications==

{{medline-entry
|title=Expression of [[ABCA2]] protein in both non-myelin-forming and myelin-forming Schwann cells in the rodent peripheral nerve.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/17240058
|abstract=We previously reported that [[ABCA2]], of the A subclass of the ATP-binding cassette (ABC) transporter superfamily, is expressed in mature oligodendrocytes and Schwann cells, the cells responsible for myelination in the brain and the peripheral nerve, respectively. However, unidentified cells expressing [[ABCA2]] also were found. Here, we provide evidence for the expression of [[ABCA2]] in the rodent sciatic nerve not only in Schwann cells, which express the Schwann cell marker S100beta and a zinc finger transcription factor Krox20 (a marker for myelin-forming Schwann cells), but also in Krox20-negative cells, which express glial fibrillary acidic protein (GFAP), a cell adhesion molecule L1, and S100beta weekly. We also analyzed developmental changes in [[ABCA2]] expression in Schwann cells. The expression of [[ABCA2]] in Krox20 /S100beta  Schwann cells was found initially in rat facial nerve at postnatal day (PD) 8, in half (52.4%) of the cells showing myelinization at PD 14, and in all of the cells in the adult stage. These results demonstrate that [[ABCA2]] is expressed in non-myelin-forming as well as in myelin-forming Schwann cells, and that [[ABCA2]] may be involved in transport of a substance associated with cellular maturation rather than initial myelin formation in both types of Schwann cells.
|mesh-terms=* ATP-Binding Cassette Transporters
* Aging
* Animals
* Animals, Newborn
* Biomarkers
* Cell Differentiation
* Early Growth Response Protein 1
* Facial Nerve
* Glial Fibrillary Acidic Protein
* Mice
* Mice, Inbred C57BL
* Myelin Sheath
* Nerve Fibers, Myelinated
* Nerve Growth Factors
* Neural Cell Adhesion Molecule L1
* Peripheral Nerves
* Rats
* Rats, Sprague-Dawley
* S100 Calcium Binding Protein beta Subunit
* S100 Proteins
* Schwann Cells
* Sciatic Nerve

|full-text-url=https://sci-hub.do/10.1016/j.neulet.2006.12.028
}}
{{medline-entry
|title=Distinct spatio-temporal expression of ABCA and ABCG transporters in the developing and adult mouse brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/16181433
|abstract=Using in situ hybridization for the mouse brain, we analyzed developmental changes in gene expression for the ATP-binding cassette (ABC) transporter subfamilies [[ABCA1]]-4 and 7, and [[ABCG1]], 2, 4, 5 and 8. In the embryonic brains, [[ABCA1]] and A7 were highly expressed in the ventricular (or germinal) zone, whereas [[ABCA2]], A3 and G4 were enriched in the mantle (or differentiating) zone. At the postnatal stages, [[ABCA1]] was detected in both the gray and white matter and in the choroid plexus. On the other hand, [[ABCA2]], A3 and A7 were distributed in the gray matter. In addition, marked up-regulation of [[ABCA2]] occurred in the white matter at 14 days-of-age when various myelin protein genes are known to be up-regulated. In marked contrast, [[ABCA4]] was selective to the choroid plexus throughout development. [[ABCG1]] was expressed in both the gray and white matters, whereas [[ABCG4]] was confined to the gray matter. [[ABCG2]] was diffusely and weakly detected throughout the brain at all stages examined. Immunohistochemistry of [[ABCG2]] showed its preferential expression on the luminal membrane of brain capillaries. Expression signals for [[ABCG5]] and G8 were barely detected at any stages. The distinct spatio-temporal expressions of individual ABCA and G transporters may reflect their distinct cellular expressions in the developing and adult brains, presumably, to regulate and maintain lipid homeostasis in the brain.
|mesh-terms=* ATP-Binding Cassette Transporters
* Aging
* Animals
* Animals, Newborn
* Brain
* Embryo, Mammalian
* Immunohistochemistry
* In Situ Hybridization
* Mice
* Mice, Inbred C57BL
* Tissue Distribution

|full-text-url=https://sci-hub.do/10.1111/j.1471-4159.2005.03369.x
}}