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__NOTOC__ ==A2M== {{medline-entry |title=Age-Dependent Variation in Glycosylation Features of Alpha-2-Macroglobulin. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31489526 |mesh-terms=* Adult * Aging * Electrophoresis, Gel, Two-Dimensional * Glycosylation * Humans * Infant, Newborn * Polysaccharides * Pregnancy-Associated alpha 2-Macroglobulins * Protein Isoforms * Umbilical Cord |keywords=* Alpha-2-macroglobulin * Glycosylation * Newborn * Plasma |full-text-url=https://sci-hub.do/10.1007/s12013-019-00883-4 }} ==AACS== {{medline-entry |title=Sex differences in subjective age-associated changes in sleep: a prospective elderly cohort study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33170149 |keywords=* aging * longitudinal studies * normative * self-report * sex characteristics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695390 }} ==ABCG2== {{medline-entry |title=Contribution of senescence in human endometrial stromal cells during proliferative phase to embryo receptivity†. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32285109 |keywords=* cellular senescence * embryo receptivity * endometrial stem cell * human endometrial stromal cell * infertility |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313258 }} {{medline-entry |title=[[ABCG2]] rs2231142 variant in hyperuricemia is modified by SLC2A9 and SLC22A12 polymorphisms and cardiovascular risk factors in an elderly community-dwelling population. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32183743 |mesh-terms=* ATP Binding Cassette Transporter, Subfamily G, Member 2 * Aged * Aged, 80 and over * Aging * Cardiovascular Diseases * China * Cohort Studies * Effect Modifier, Epidemiologic * Epistasis, Genetic * Female * Genes, Modifier * Genetic Predisposition to Disease * Genome-Wide Association Study * Glucose Transport Proteins, Facilitative * Humans * Hyperuricemia * Independent Living * Male * Neoplasm Proteins * Organic Anion Transporters * Organic Cation Transport Proteins * Polymorphism, Single Nucleotide * Risk Factors * Uric Acid |keywords=* ABCG2 * Hypertension * Polymorphisms * Triglyceridemia * Uric acid |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077001 }} ==ABL1== {{medline-entry |title=European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32127639 |mesh-terms=* Aniline Compounds * Antineoplastic Agents * Clinical Decision-Making * Consensus Development Conferences as Topic * Dasatinib * Disease Management * Fusion Proteins, bcr-abl * Gene Expression * Humans * Imatinib Mesylate * Leukemia, Myelogenous, Chronic, BCR-ABL Positive * Life Expectancy * Monitoring, Physiologic * Nitriles * Protein Kinase Inhibitors * Pyrimidines * Quality of Life * Quinolines * Survival Analysis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214240 }} ==ABO== {{medline-entry |title=Allelic distribution of [i][[ABO]][/i] gene in Chinese centenarians. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33103040 |keywords=* ABO gene * centenarian * longevity * single nucleotide polymorphisms |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574633 }} {{medline-entry |title=Genetically Determined [[ABO]] Blood Group and its Associations With Health and Disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31969017 |mesh-terms=* ABO Blood-Group System * Adult * Age Factors * Aged * Cardiovascular Diseases * Female * Gene Frequency * Genetic Predisposition to Disease * Health Status * Healthy Aging * Humans * Incidence * Male * Middle Aged * Phenotype * Polymorphism, Single Nucleotide * Prevalence * Risk Assessment * Risk Factors * United Kingdom |keywords=* ABO * aging * blood * genetics * hypertension * phenotype |full-text-url=https://sci-hub.do/10.1161/ATVBAHA.119.313658 }} ==ABR== {{medline-entry |title=[Hidden hearing loss and early identification]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32791650 |mesh-terms=* Acoustic Stimulation * Audiometry, Pure-Tone * Auditory Threshold * Evoked Potentials, Auditory, Brain Stem * Hearing Loss, Noise-Induced * Humans * Noise |keywords=* aging * drug damage * hidden hearing loss * noise exposure |full-text-url=https://sci-hub.do/10.13201/j.issn.2096-7993.2020.07.023 }} {{medline-entry |title=Aging But Not Age-Related Hearing Loss Dominates the Decrease of Parvalbumin Immunoreactivity in the Primary Auditory Cortex of Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32327469 |keywords=* age-related hearing loss * aging * mouse primary auditoy cortex * parvalbumin |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210488 }} {{medline-entry |title=Hearing loss through apoptosis of the spiral ganglion neurons in apolipoprotein E knockout mice fed with a western diet. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31948760 |mesh-terms=* Aging * Animals * Apolipoproteins E * Apoptosis * Diet, Western * Disease Models, Animal * Hearing Loss * Male * Mice * Mice, Inbred C57BL * Mice, Knockout * Neurons * Spiral Ganglion |keywords=* Apoptosis * Atherosclerosis * Hearing loss * Reactive oxygen specie * Spiral ganglion neurons |full-text-url=https://sci-hub.do/10.1016/j.bbrc.2019.12.100 }} {{medline-entry |title=Effects of enriched endogenous omega-3 fatty acids on age-related hearing loss in mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31771637 |mesh-terms=* Aging * Animals * Body Weight * Caenorhabditis elegans Proteins * Cochlea * Evoked Potentials, Auditory, Brain Stem * Fatty Acid Desaturases * Fatty Acids, Omega-3 * Male * Mice * Mice, Inbred C57BL * Mice, Transgenic * Neurons * Presbycusis * Spiral Ganglion |keywords=* Age-related hearing loss * C57BL/6 mouse * Cochlea * Omega-3 (n-3) fatty acids |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878677 }} {{medline-entry |title=Hearing impairment and associated morphological changes in pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31601840 |mesh-terms=* Aging * Animals * Cochlea * Evoked Potentials, Auditory, Brain Stem * Genotype * Hearing * Hearing Loss * Inflammation * Male * Mice * Mice, Knockout * Models, Animal * Neovascularization, Pathologic * Neurons * Pituitary Adenylate Cyclase-Activating Polypeptide * Proteome * Proto-Oncogene Proteins c-fos |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787024 }} {{medline-entry |title=Global nurse/midwife workforce and reproductive health through social ecology lens. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31402489 |mesh-terms=* Adolescent * Cross-Sectional Studies * Employment * Female * Global Health * Health Education * Humans * Income * Life Expectancy * Male * Midwifery * Pregnancy * Reproductive Health * Social Environment * Socioeconomic Factors * Workforce |keywords=* global health * nurse/midwife workforce * reproductive health * social ecology |full-text-url=https://sci-hub.do/10.1111/phn.12648 }} ==ACD== {{medline-entry |title=Genetics of cognitive trajectory in Brazilians: 15 years of follow-up from the Bambuí-Epigen Cohort Study of Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31792241 |mesh-terms=* Age Factors * Aged * Aging * Brazil * Cognition * Cognitive Dysfunction * Cohort Studies * Female * Follow-Up Studies * Genetic Predisposition to Disease * Genome-Wide Association Study * Humans * Male * Middle Aged * Polymorphism, Single Nucleotide |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889148 }} ==ACE== {{medline-entry |title=Elite swimmers possess shorter telomeres than recreationally active controls. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33068677 |keywords=* Aging * Athlete * Exercise * Genetics |full-text-url=https://sci-hub.do/10.1016/j.gene.2020.145242 }} {{medline-entry |title=Coronavirus Disease-2019 Conundrum: RAS Blockade and Geriatric-Associated Neuropsychiatric Disorders. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32850927 |keywords=* ACE2 * ACEIs * ARBs * COVID-19 * RAS * SARS-CoV-2 * geriatrics * neuropsychiatric disorders |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431869 }} {{medline-entry |title=Pregnancy Protects Hyperandrogenemic Female Rats From Postmenopausal Hypertension. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32755410 |keywords=* aging * endothelin * menopause * nitric oxide * renin-angiotensin system |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429272 }} {{medline-entry |title=Heart failure is associated with accelerated age related metabolic bone disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32498656 |keywords=* Heart failure * comorbidities * geriatrics * metabolic bone disease * osteoporosis |full-text-url=https://sci-hub.do/10.1080/00015385.2020.1771885 }} {{medline-entry |title=Management of heart failure: an Italian national survey on fellows/specialists in geriatrics. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32383033 |mesh-terms=* Aged * Geriatrics * Heart Failure * Humans * Italy * Specialization * Stroke Volume * Surveys and Questionnaires |keywords=* Aged, 65 years or over * Care survey * Health * Heart failure |full-text-url=https://sci-hub.do/10.1007/s40520-020-01577-1 }} {{medline-entry |title=Angiotensin-Converting Enzyme ([[ACE]]) genetic variation and longevity in Peruvian older people: a cross-sectional study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32281429 |mesh-terms=* Aged * Aged, 80 and over * Cross-Sectional Studies * Female * Genetic Variation * Humans * Longevity * Male * Middle Aged * Peptidyl-Dipeptidase A * Peru * Polymorphism, Genetic |keywords=* ACE gene * Longevity * Perú * ageing |full-text-url=https://sci-hub.do/10.1080/03014460.2020.1748227 }} {{medline-entry |title=COVID-19 and chronological aging: senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32229706 |mesh-terms=* Age Factors * Aged * Aged, 80 and over * Aging * Angiotensin-Converting Enzyme 2 * Antiviral Agents * Azithromycin * Betacoronavirus * COVID-19 * Coronavirus Infections * Dipeptidyl Peptidase 4 * Humans * Hydroxychloroquine * Pandemics * Peptidyl-Dipeptidase A * Pneumonia, Viral * Quercetin * Receptors, Virus * SARS-CoV-2 |keywords=* Azithromycin * COVID-19 * Doxycycline * Hydroxy-chloroquine * Quercetin * Rapamycin * aging * antibiotic * corona virus * drug repurposing * prevention * senescence * senolytic drug therapy * viral replication |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202514 }} {{medline-entry |title=[i]A[/i]ngiotensin Converting Enzyme Inhibitors [i]C[/i]ombined with [i]E[/i]xercise for Hypertensive [i]S[/i]eniors (The [[ACE]]S Trial): Study Protocol of a Randomized Controlled Trial. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32039215 |keywords=* aging * antihypertensive * exercise * functional status * hypertension |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6988302 }} {{medline-entry |title=Vascular age. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32013519 |mesh-terms=* Adolescent * Adult * Aged * Aging * Angiotensin-Converting Enzyme Inhibitors * Atherosclerosis * Child * Elasticity * Humans * Middle Aged * Perindopril * Pulse Wave Analysis * Vascular Stiffness * Young Adult |keywords=* ACE inhibitors * CT angiography * atorvastatin * dyslipidemia * hypertension * intima media thickness (IMT) * perindopril * pulse wave velocity (PWV) * statins * vascular age }} ==ACE2== {{medline-entry |title=How Does SARS-CoV-2 Affect the Central Nervous System? A Working Hypothesis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33304284 |keywords=* ACE2 * Alzheimer disease * Ang(1-7)/Mas * COVID-19 * RAAS * SARS-CoV * brain aging * neurodegenerative and psychiatric disorders abstract |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701095 }} {{medline-entry |title=Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33112891 |mesh-terms=* Aging * Angiotensin-Converting Enzyme 2 * Betacoronavirus * Binding Sites * COVID-19 * Carrier Proteins * Computational Biology * Coronavirus Infections * Female * Gene Expression Regulation, Enzymologic * Gene Ontology * Humans * Interferons * Lung * Male * Metalloproteases * Neovascularization, Physiologic * Organ Specificity * Pandemics * Peptidyl-Dipeptidase A * Pneumonia, Viral * Promoter Regions, Genetic * RNA, Messenger * Receptors, Virus * Renin-Angiotensin System * SARS-CoV-2 * Sex Characteristics * Single-Cell Analysis * Transcription Factors * Transcription Initiation Site * Virus Attachment |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592753 }} {{medline-entry |title=A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32854108 |mesh-terms=* Aging * Angiotensin-Converting Enzyme 2 * Animals * Betacoronavirus * COVID-19 * COVID-19 Vaccines * Coronavirus Infections * Disease Models, Animal * Female * Forkhead Transcription Factors * Humans * Interferon-alpha * Interferons * Interleukins * Male * Mice * Mice, Inbred BALB C * Mice, Transgenic * Models, Molecular * Pandemics * Peptidyl-Dipeptidase A * Pneumonia, Viral * Receptors, Virus * SARS-CoV-2 * Viral Vaccines |full-text-url=https://sci-hub.do/10.1038/s41586-020-2708-8 }} {{medline-entry |title=COVID-19 and Senotherapeutics: Any Role for the Naturally-occurring Dipeptide Carnosine? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32765939 |keywords=* acetyl-carnosine * aging * carnosine * inflammation * lungs * olfaction * virus |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390525 }} {{medline-entry |title=The dual impact of [[ACE2]] in COVID-19 and ironical actions in geriatrics and pediatrics with possible therapeutic solutions. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32653522 |mesh-terms=* Age Factors * Aged * Aged, 80 and over * Angiotensin-Converting Enzyme 2 * Anti-Inflammatory Agents * Betacoronavirus * COVID-19 * Child * Child, Preschool * Coronavirus * Coronavirus Infections * Female * Geriatrics * Humans * Infant * Infant, Newborn * Male * Pandemics * Pediatrics * Peptidyl-Dipeptidase A * Pneumonia, Viral * Protein Binding * Receptors, Virus * Renin-Angiotensin System * SARS-CoV-2 * Severe Acute Respiratory Syndrome * Virus Internalization |keywords=* ACE2 * Angiotensin 2 * Angiotensin-(1–7) * Corona virus * Glycoprotein spikes * RAAS system |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347488 }} {{medline-entry |title=The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of "inflame-aging". |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32529477 |mesh-terms=* Adipocytes * Age Factors * Aged * Aging * Angiotensin II Type 2 Receptor Blockers * Autophagy * Betacoronavirus * COVID-19 * Cellular Senescence * Coronavirus Infections * Cytokine Release Syndrome * Cytokines * Humans * Immune System * Inflammation * Pandemics * Pneumonia, Viral * Reactive Oxygen Species * Receptor, Angiotensin, Type 2 * SARS-CoV-2 * Vitamin D * Vitamin D Deficiency |keywords=* ACE2 receptor * Autophagy * COVID-19 * Cytokine storm * Senescent cell * Vitamin D |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289226 }} {{medline-entry |title=Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32510973 |mesh-terms=* Adaptive Immunity * Angiotensin-Converting Enzyme 2 * Animals * Betacoronavirus * COVID-19 * Coronavirus Infections * DNA, Mitochondrial * Gene Expression Regulation, Viral * Host Microbial Interactions * Humans * Immunity, Innate * Mitochondria * Pandemics * Peptidyl-Dipeptidase A * Pneumonia, Viral * RNA, Viral * SARS-CoV-2 * Virus Replication |keywords=* COVID-19 * SARS-CoV * aging * coronavirus * mitochondria * mitochondrial DNA |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381712 }} {{medline-entry |title=A Mouse Model of SARS-CoV-2 Infection and Pathogenesis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32485164 |mesh-terms=* Aging * Angiotensin-Converting Enzyme 2 * Animals * Betacoronavirus * Brain * COVID-19 * CRISPR-Cas Systems * Coronavirus Infections * Cytokines * Disease Models, Animal * Gene Knock-In Techniques * Lung * Lung Diseases, Interstitial * Mice, Inbred C57BL * Nose * Pandemics * Peptidyl-Dipeptidase A * Pneumonia, Viral * RNA, Viral * SARS-CoV-2 * Stomach * Trachea * Viral Load * Virus Replication |keywords=* SARS-CoV-2 * angiotensin-converting enzyme II * hACE2-KI/NIFDC * mouse model * pathogenesis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250783 }} {{medline-entry |title=COVID-19-associated cardiovascular morbidity in older adults: a position paper from the Italian Society of Cardiovascular Researches. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32430627 |mesh-terms=* Age Factors * Aged * Betacoronavirus * COVID-19 * Cardiovascular Diseases * Coronavirus Infections * Female * Humans * Italy * Male * Middle Aged * Pandemics * Pneumonia, Viral * Risk Factors * SARS-CoV-2 |keywords=* Acute myocardial injury * Aging * COVID-19 * Cardiovascular system * Frailty * SARS-CoV-2 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237344 }} {{medline-entry |title=Gut microbiota and Covid-19- possible link and implications. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32430279 |mesh-terms=* Aging * Betacoronavirus * COVID-19 * Coronavirus Infections * Diet * Dysbiosis * Gastrointestinal Microbiome * Gastrointestinal Tract * Homeostasis * Humans * Immunity * Lung * Pandemics * Pneumonia, Viral * SARS-CoV-2 |keywords=* Covid-19 * Diet * Dysbiosis * Gut microbiome * Immunity * Lung microbiota * SARS-CoV-2 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217790 }} {{medline-entry |title=Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32389499 |mesh-terms=* Aged * Aged, 80 and over * Aging * Angiotensin-Converting Enzyme 2 * Antibodies, Monoclonal, Humanized * Betacoronavirus * COVID-19 * Comorbidity * Coronavirus Infections * Female * Humans * Inflammation * Interferon Type I * Interleukin-6 * Male * Pandemics * Peptidyl-Dipeptidase A * Pneumonia, Viral * SARS-CoV-2 * Severe Acute Respiratory Syndrome |keywords=* COVID-19 * Cardiovascular diseases * Host-directed therapies * Inflamm-aging * SARS-CoV-2 * interleukin-6 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252014 }} {{medline-entry |title=Restoration of the Renin-Angiotensin System Balance Is a Part of the Effect of Fasting on Cardiovascular Rejuvenation: Role of Age and Fasting Models. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31571520 |keywords=* aging * cardiac hypertrophy index * intermittent fasting * renin–angiotensin system (RAS) |full-text-url=https://sci-hub.do/10.1089/rej.2019.2254 }} {{medline-entry |title=Angiotensin 1-7 alleviates aging-associated muscle weakness and bone loss, but is not associated with accelerated aging in [[ACE2]]-knockout mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31519791 |mesh-terms=* Adipose Tissue * Aging * Angiotensin I * Angiotensin-Converting Enzyme 2 * Animals * Body Weight * Bone Resorption * Cyclin-Dependent Kinase Inhibitor p16 * Forelimb * Gene Deletion * Hand Strength * Male * Mice, Inbred C57BL * Mice, Knockout * Muscle Weakness * Muscles * Organ Size * PAX3 Transcription Factor * Peptide Fragments * Peptidyl-Dipeptidase A * Proto-Oncogene Proteins * Receptors, G-Protein-Coupled * Renin-Angiotensin System * Time Factors |keywords=* Angiotensin 1-7 * Angiotensin Converting Enzyme 2 * Mas receptor * Muscle weakness * osteoporosis |full-text-url=https://sci-hub.do/10.1042/CS20190573 }} ==ACLY== {{medline-entry |title=In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32666259 |keywords=* Aging * Apoptosis/necrosis * Caloric restriction mimetics * Hydroxycitric acid * Oxidative stress * Sch9 and Ras2 pathways |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527365 }} ==ACR== {{medline-entry |title=Progenitor cell niche senescence reflects pathology of the parotid salivary gland in primary Sjögren's syndrome. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32159757 |keywords=* p16 * primary Sjögren’s syndrome * salivary gland * salivary gland progenitor cells * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516109 }} {{medline-entry |title=Jumping Joints: The Complex Relationship Between Osteoarthritis and Jumping Mechanography. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31655874 |keywords=* Aging * Jumping mechanography * Muscle * Osteoarthritis * Sarcopenia |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994439 }} ==ACVR1== {{medline-entry |title=Fibrodysplasia Ossificans Progressiva (FOP): A Segmental Progeroid Syndrome. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31998237 |keywords=* ACVR1 * activin A * cell senescence * fibrodysplasia ossificans progressiva * progeroid syndrome |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966325 }} ==ADA== {{medline-entry |title=Adenosine Metabolism in the Cerebral Cortex from Several Mice Models during Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33023260 |keywords=* adenosine metabolism * aging * animal models * glutamate * purinergic signaling |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582336 }} ==ADAM10== {{medline-entry |title=NKG2D Ligand Shedding in Response to Stress: Role of [[ADAM10]]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32269567 |keywords=* ADAM10 * NKG2D * NKG2D ligands * cancer * chemotherapy * senescence * shedding |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109295 }} {{medline-entry |title=Chronic Mild Stress Modified Epigenetic Mechanisms Leading to Accelerated Senescence and Impaired Cognitive Performance in Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32050516 |mesh-terms=* ADAM10 Protein * Aging * Amyloid Precursor Protein Secretases * Animals * Cognition * Epigenesis, Genetic * Female * Glial Fibrillary Acidic Protein * Glycogen Synthase Kinase 3 beta * Mechanistic Target of Rapamycin Complex 1 * Membrane Proteins * Mice * MicroRNAs * NF-kappa B * Reactive Oxygen Species * Signal Transduction * Stress, Psychological |keywords=* Alzheimer’s disease * SAMP8 * SAMR1 * age-related cognitive decline * autophagy * cognition * epigenetics * inflammation * oxidative stress * senescence * stress |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037343 }} ==ADAM17== {{medline-entry |title=ACE2/[[ADAM17]]/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33117379 |mesh-terms=* ADAM17 Protein * Aged * Aging * Angiotensin-Converting Enzyme 2 * Betacoronavirus * COVID-19 * Comorbidity * Coronavirus Infections * Female * Humans * Male * Pandemics * Peptidyl-Dipeptidase A * Pneumonia, Viral * Receptors, Interleukin-6 * Risk Factors * SARS-CoV-2 * Serine Endopeptidases * Tumor Necrosis Factor-alpha |keywords=* ACE2 * ADAM17 * COVID-19 pathophysiology * SARS-CoV-2 * TMPRSS2 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575774 }} ==ADH5== {{medline-entry |title=Can Serum Nitrosoproteome Predict Longevity of Aged Women? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33260845 |keywords=* aging * cardiovascular disease * muscle atrophy * nitrosative stress * proteomics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731247 }} ==ADM== {{medline-entry |title=Assessment of age-related differences in decomposition-based quantitative EMG in the intrinsic hand muscles: A multivariate approach. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32693193 |keywords=* Aging * Decomposition-based quantitative electromyography (DQEMG) * Hand muscle * Jiggle * Motor unit potential (MUP) * Multivariate |full-text-url=https://sci-hub.do/10.1016/j.clinph.2020.06.017 }} {{medline-entry |title=Evaluation of transcriptional levels of the natriuretic peptides, endothelin-1, adrenomedullin, their receptors and long non-coding RNAs in rat cardiac tissue as cardiovascular biomarkers of aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31629715 |keywords=* ADM system * Aging * Biomarkers * ET-1system * LncRNA * NP system |full-text-url=https://sci-hub.do/10.1016/j.peptides.2019.170173 }} ==ADORA2B== {{medline-entry |title=Adenosine A2B receptor: A pathogenic factor and a therapeutic target for sensorineural hearing loss. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33131093 |keywords=* ADA-deficiency * adenosine deaminase deficiency * aging * myelin protein zero * myelination |full-text-url=https://sci-hub.do/10.1096/fj.202000939R }} ==ADRA2A== {{medline-entry |title=α2A-Adrenergic Receptor Inhibits the Progression of Cervical Cancer Through Blocking PI3K/AKT/mTOR Pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33116632 |keywords=* ADRA2A * PI3K/Akt/mTOR pathway * cervical cancer * metastasis * proliferation * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574911 }} ==AFM== {{medline-entry |title=Photocatalytic aging process of Nano-TiO coated polypropylene microplastics: Combining atomic force microscopy and infrared spectroscopy ([[AFM]]-IR) for nanoscale chemical characterization. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33080556 |keywords=* AFM-IR * Aging process * Microplastics * Nanoscale characterization * Polypropylene |full-text-url=https://sci-hub.do/10.1016/j.jhazmat.2020.124159 }} {{medline-entry |title=Nanoscale infrared, thermal and mechanical properties of aged microplastics revealed by an atomic force microscopy coupled with infrared spectroscopy ([[AFM]]-IR) technique. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32702545 |keywords=* AFM-IR * Aging process * Mechanical properties * Microplastics (MPs) * Thermal analysis |full-text-url=https://sci-hub.do/10.1016/j.scitotenv.2020.140944 }} {{medline-entry |title=Detecting zeta potential of polydimethylsiloxane (PDMS) in electrolyte solutions with atomic force microscope. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32521351 |keywords=* AFM * Air plasma treatment * Liquid aging * PDMS * Zeta potential |full-text-url=https://sci-hub.do/10.1016/j.jcis.2020.05.061 }} {{medline-entry |title=Recent Applications of Advanced Atomic Force Microscopy in Polymer Science: A Review. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32429499 |keywords=* AFM-IR * blends * nanoscale characterization * polymer aging * polymer composites * polymers |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284686 }} {{medline-entry |title=Active fractions of mannoproteins derived from yeast cell wall stimulate innate and acquired immunity of adult and elderly dogs. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32288071 |keywords=* AFM, active fraction of mannoproteins * ALP, alkaline phosphatase * ALT, alanine aminotransferase * Ageing * CBC, complete blood count * CD21+, B lymphocyte * CD4+, auxiliary T lymphocyte * CD5+, total T lymphocyte * CD8+, cytotoxic lymphocyte * CO, cells only * Canine * DCHT, delayed cutaneous hypersensitivity test * FOSs, fructooligosaccharides * GALT, gut-associated lymphoid tissue * IL-12, interleukin 12 * IgA, immunoglobulin A * Immunosenescence * LPS, bacterial lipopolysaccharide * MOSs, mannanoligosaccharides * NADPH, reduced nicotinamide adenine dinucleotide phosphate * NO, nitrogen monoxide * NOS, nitric oxide synthase * OD, optical density * PMA, phorbol myristate acetate * Saccharomyces cerevisiae * Senescence * TNF-α, tumour necrosis factor alpha * Th1, helper T lymphocyte |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126846 }} {{medline-entry |title=The Effect of Waste Engine Oil and Waste Polyethylene on UV Aging Resistance of Asphalt. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32155867 |keywords=* Fourier transform infrared spectroscopy * atomic force microscopy * gel permeation chromatography * ultraviolet aging * waste engine oil * waste polyethylene |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182932 }} {{medline-entry |title=Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32098962 |mesh-terms=* Aging * Animal Feed * Animals * Bacillus subtilis * Biomarkers * Caenorhabditis elegans * Caenorhabditis elegans Proteins * Comamonas * Escherichia coli * Forkhead Transcription Factors * Hot Temperature * Insulin * Microbiota * Microscopy, Atomic Force * Mutation * Receptor, Insulin * Signal Transduction * Ultraviolet Rays |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042263 }} {{medline-entry |title=Nanomechanical insights: Amyloid beta oligomer-induced senescent brain endothelial cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31513781 |mesh-terms=* Alzheimer Disease * Amyloid beta-Peptides * Biomechanical Phenomena * Brain * Cell Culture Techniques * Cell Membrane * Cellular Senescence * Endothelial Cells * Endothelium, Vascular * Humans * Microscopy, Atomic Force * Vascular Endothelial Growth Factor A |keywords=* Amyloid beta oligomer * Atomic force microscopy * Brain endothelial cells * Nanoindentation * Nanomechanical properties * Senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791778 }} ==AGER== {{medline-entry |title=Vitamin D3 regulates apoptosis and proliferation in the testis of D-galactose-induced aged rat model. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31575929 |mesh-terms=* Aging * Animals * Antioxidants * Apoptosis * Cell Proliferation * Cholecalciferol * Down-Regulation * Galactose * Male * Oxidative Stress * Rats * Spermatogenesis * Testis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773724 }} ==AGT== {{medline-entry |title=SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31441382 |keywords=* Aging * SQSTM1 * autophagy * oxidative stress * senescence * vascular biology |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469683 }} ==AHR== {{medline-entry |title=Indoles from the commensal microbiota act via the [[AHR]] and IL-10 to tune the cellular composition of the colonic epithelium during aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32817517 |mesh-terms=* Aging * Animals * Bacteria * Cell Differentiation * Epithelial Cells * Female * Goblet Cells * Indoles * Interleukin-10 * Interleukins * Male * Mice * Mice, Inbred BALB C * Mice, Inbred C57BL * Mice, Knockout * Microbiota * Mucus * Receptors, Aryl Hydrocarbon * Signal Transduction |keywords=* aging * goblet cell * intestinal homeostasis * mucus |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474656 }} {{medline-entry |title=Role of the Aryl Hydrocarbon Receptor in Environmentally Induced Skin Aging and Skin Carcinogenesis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31795255 |mesh-terms=* Animals * Environmental Exposure * Extracellular Matrix * Humans * Receptors, Aryl Hydrocarbon * Skin Aging * Skin Neoplasms |keywords=* DNA damage * UV radiation * extracellular matrix * extrinsic skin aging * melanoma * particulate matter * pigmentation * polycyclic aromatic hydrocarbons * squamous cell carcinoma |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928879 }} ==AIP== {{medline-entry |title=[Aryl hydrocarbon receptor interacting protein ([[AIP]]) in human dermis during aging.] |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33280328 |keywords=* AIP * PCNA * aging * fibroblasts * skin }} {{medline-entry |title=Sex-Specific Association between Serum Vitamin D Status and Lipid Profiles: A Cross-Sectional Study of a Middle-Aged and Elderly Chinese Population. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32350171 |keywords=* atherogenic index of plasma * dyslipidaemia * gerontology * sex difference * vitamin D |full-text-url=https://sci-hub.do/10.3177/jnsv.66.105 }} {{medline-entry |title=The oblique effect: The relationship between profiles of visuospatial preference, cognition, and brain connectomics in older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31654648 |mesh-terms=* Aged * Brain * Cognition * Connectome * Diffusion Tensor Imaging * Executive Function * Female * Humans * Judgment * Male * Middle Aged * Neuropsychological Tests * Pattern Recognition, Visual * Spatial Processing |keywords=* Aging * Executive function * Oblique effect * Perception * Structural connectivity * Visuospatial processing |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887099 }} ==ALAS1== {{medline-entry |title=Heterozygous disruption of [[ALAS1]] in mice causes an accelerated age-dependent reduction in free heme, but not total heme, in skeletal muscle and liver. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33307066 |keywords=* 5-Aminolevulinate synthase 1 (ALAS1) * 5-Aminolevulinic acid (ALA) * Aging * Free heme * Liver * Skeletal muscle |full-text-url=https://sci-hub.do/10.1016/j.abb.2020.108721 }} ==ALB== {{medline-entry |title=Effects of Age on Inflammatory Profiles and Nutrition/Energy Metabolism in Domestic Cats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33262938 |keywords=* M/L ratio * SAA * aging * domestic cats * obesity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695597 }} ==ALK== {{medline-entry |title=Catalog of Lung Cancer Gene Mutations Among Chinese Patients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32850378 |keywords=* China * aging * gene mutation * lung cancer * pathology * tobacco smoking |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417348 }} ==ALKBH8== {{medline-entry |title=Loss of epitranscriptomic control of selenocysteine utilization engages senescence and mitochondrial reprogramming . |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31765888 |mesh-terms=* AlkB Homolog 8, tRNA Methyltransferase * Animals * Cells, Cultured * Cellular Senescence * Epigenesis, Genetic * Gene Deletion * Gene Expression Profiling * Humans * Mice * Mitochondria * Oxygen Consumption * Selenocysteine * Uncoupling Protein 2 |keywords=* Epitranscriptome * Mitochondria * Selenium * Senescence * Uncoupling protein |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904832 }} ==ALOX12== {{medline-entry |title=Arachidonate 12-lipoxygenase and 12-hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32265301 |keywords=* aging * arachidonic acid (AA) (ARA) * cancer biology * cell proliferation * fibroblast * pancreatic cancer * stromal cell |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242692 }} ==ALOX5== {{medline-entry |title=Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31642348 |mesh-terms=* Aging * Alanine * Animals * Arachidonate 5-Lipoxygenase * Asparagine * Body Weight * Female * Gene Knock-In Techniques * Leukotrienes * Linoleic Acid * Male * Mice * Mutation * PPAR gamma * Phenylalanine |keywords=* eicosanoids * inflammation * leukotrienes * lipoxygenase * resolvins |full-text-url=https://sci-hub.do/10.1089/ars.2019.7751 }} ==AMH== {{medline-entry |title=Beyond premature ovarian insufficiency: Staging reproductive aging in adolescent and young adult cancer survivors. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33141175 |keywords=* STRAW * adolescent and young adult cancer * menopausal transition * premature ovarian insufficiency * reproductive aging |full-text-url=https://sci-hub.do/10.1210/clinem/dgaa797 }} {{medline-entry |title=Correlates and Timing of Reproductive Aging Transitions in a Global Cohort of Midlife Women With Human Immunodeficiency Virus: Insights From the REPRIEVE Trial. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32645159 |keywords=* Cardiometabolic Risk * HIV * Menopause * Reproductive Aging * Sex * Women |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347076 }} {{medline-entry |title=Epigenetic clock measuring age acceleration via DNA methylation levels in blood is associated with decreased oocyte yield. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32285295 |keywords=* Aging * DNA methylation * Epigenetic clock * Epigenetics * Infertility * Methylome * Ovarian aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244694 }} {{medline-entry |title=Modeling Variation in the Reproductive Lifespan of Female Adolescent and Young Adult Cancer Survivors Using [[AMH]]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32270202 |keywords=* AMH * adolescent and young adult cancer * functional principal components analysis * ovarian reserve * reproductive lifespan |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329316 }} {{medline-entry |title=Improving Prediction of Age at Menopause Using Multiple Anti-Müllerian Hormone Measurements: the Tehran Lipid-Glucose Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32109280 |keywords=* Tehran Lipid and Glucose Study (TLGS) * anti-müllerian hormone (AMH) * menopause * reproductive aging |full-text-url=https://sci-hub.do/10.1210/clinem/dgaa083 }} {{medline-entry |title=Antimullerian Hormone and Impending Menopause in Late Reproductive Age: The Study of Women's Health Across the Nation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31965189 |keywords=* aging * female reproductive endocrinology * gonadotropins * inhibin/activin/follistatin/AMH * menopause * ovaries |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067546 }} {{medline-entry |title=Basal characterization and in vitro differentiation of putative stem cells derived from the adult mouse ovary. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31900800 |mesh-terms=* Aging * Animals * Anti-Mullerian Hormone * Antigens, Ly * Cell Differentiation * Cell Shape * Female * Lewis X Antigen * Membrane Proteins * Mice, Inbred C57BL * Ovary * Stem Cells |keywords=* BMP-4 * Multipotent * Ovary * Retinoic acid * Stem cells |full-text-url=https://sci-hub.do/10.1007/s11626-019-00411-x }} {{medline-entry |title=Serum anti-Müllerian hormone concentration and follicle density throughout reproductive life and in different diseases-implications in fertility preservation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31782794 |mesh-terms=* Adolescent * Adult * Aging * Anti-Mullerian Hormone * Child * Child, Preschool * Female * Fertility Preservation * Humans * Ovarian Follicle * Retrospective Studies * Young Adult |keywords=* anti-Müllerian hormone * cancer * fertility preservation * ovarian reserve * ovarian tissue * primary follicle * primordial follicle |full-text-url=https://sci-hub.do/10.1093/humrep/dez215 }} {{medline-entry |title=Associations Between Anti-Mullerian Hormone and Cardiometabolic Health in Reproductive Age Women Are Explained by Body Mass Index. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31586179 |mesh-terms=* Adult * Anti-Mullerian Hormone * Biomarkers * Body Mass Index * Cardiovascular Diseases * Case-Control Studies * Cross-Sectional Studies * Female * Follow-Up Studies * Humans * Incidence * Infertility, Female * Polycystic Ovary Syndrome * Prognosis * United States |keywords=* anti-mullerian hormone (AMH) * cardiometabolic health * cardiovascular risk * ovarian aging * ovarian reserve markers * reproductive aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024739 }} {{medline-entry |title=Relationships between antral follicle count, blood serum concentration of anti-Müllerian hormone and fertility in mares. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31586925 |mesh-terms=* Aging * Animals * Anti-Mullerian Hormone * Female * Fertility * Horses * Ovarian Follicle * Ovulation |keywords=* AMH * Anzahl Follikel * Ovar * Pferd * Ultraschall * compte folliculaire * conta dei follicoli * ecografia * equine * equini * follicle count * ovaia * ovaire * ovary * reproductive status * stato riproduttivo * ultrasonography * Reproduktionsstatus * échographie * équin * état reproducteur |full-text-url=https://sci-hub.do/10.17236/sat00225 }} ==AMT== {{medline-entry |title=A multi-method comparison of autobiographical memory impairments amongst younger and older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32162531 |keywords=* Depression * aging * episodic memory * overgeneral * specificity |full-text-url=https://sci-hub.do/10.1080/13607863.2020.1729338 }} ==ANGPTL2== {{medline-entry |title=Circulating angiopoietin-like protein 2 levels and mortality risk in patients receiving maintenance hemodialysis: a prospective cohort study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31840173 |mesh-terms=* Aged * Angiopoietin-like Proteins * Biomarkers * C-Reactive Protein * Disease Progression * Female * Humans * Kidney Diseases * Male * Middle Aged * Prognosis * Prospective Studies * Renal Dialysis * Risk Factors * Survival Rate |keywords=* aging * angiopoietin-like protein (ANGPTL) 2 * chronic inflammation * hemodialysis * mortality risk |full-text-url=https://sci-hub.do/10.1093/ndt/gfz236 }} ==ANK3== {{medline-entry |title=Age-related atrophy of cortical thickness and genetic effect of [[ANK3]] gene in first episode MDD patients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32911427 |keywords=* ANK3 * Aging * Cortical thickness * Major depressive disorder * Neuroimage |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7490581 }} ==AOX1== {{medline-entry |title=N1-Methylnicotinamide: An Anti-Ovarian Aging Hormetin? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32711159 |keywords=* AMPK * MNAM * Ovarian Aging * ROS |full-text-url=https://sci-hub.do/10.1016/j.arr.2020.101131 }} ==AP2B1== {{medline-entry |title=Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31860870 |mesh-terms=* Adaptor Protein Complex beta Subunits * Aging * Alzheimer Disease * Animals * Astrocytes * Autophagy * Cellular Senescence * Dynamin I * Genes, Neurofibromatosis 1 * Mice * RNA, Circular * Rats * Rats, Sprague-Dawley |keywords=* aging * astrocyte * autophagy * biological function * circular RNA |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949063 }} ==APC== {{medline-entry |title=Differences between blacks and whites in well-being, beliefs, emotional states, behaviors and survival, 1978-2014. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32925952 |mesh-terms=* Adult * African Americans * Aged * Behavior * Cohort Studies * Emotions * European Continental Ancestry Group * Female * Hispanic Americans * Humans * Longevity * Male * Middle Aged * Socioeconomic Factors * Survival Analysis * United States |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489510 }} {{medline-entry |title=Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32771388 |keywords=* Compliance * Senescence * Stem Cell |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7672319 }} {{medline-entry |title=Burden of musculoskeletal disorders in Iran during 1990-2017: estimates from the Global Burden of Disease Study 2017. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32651719 |mesh-terms=* Female * Global Burden of Disease * Global Health * Humans * Iran * Life Expectancy * Male * Musculoskeletal Diseases * Quality-Adjusted Life Years |keywords=* Burden * DALY * Decomposition * Global burden of diseases * Iran * Musculoskeletal diseases |full-text-url=https://sci-hub.do/10.1007/s11657-020-00767-8 }} {{medline-entry |title=Fall-related mortality trends in older Japanese adults aged ≥65 years: a nationwide observational study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31831549 |mesh-terms=* Accidental Falls * Aged * Aged, 80 and over * Female * Geriatrics * Health Policy * Health Services Needs and Demand * Humans * Japan * Male * Mortality * Public Health |keywords=* adult intensive & critical care * epidemiology * geriatric medicine * health & safety * health policy * public health |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924807 }} {{medline-entry |title=Stroke Mortality Rates and Trends in Romania, 1994-2017. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31624036 |mesh-terms=* Adult * Age Distribution * Aged * Aged, 80 and over * Cause of Death * Female * Humans * Life Expectancy * Male * Middle Aged * Prognosis * Registries * Risk Assessment * Risk Factors * Romania * Sex Distribution * Stroke * Time Factors |keywords=* Mortality * age-standardized mortality rates * life expectancy * stroke |full-text-url=https://sci-hub.do/10.1016/j.jstrokecerebrovasdis.2019.104431 }} {{medline-entry |title=A new approach to quantifying the EEG during walking: Initial evidence of gait related potentials and their changes with aging and dual tasking. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31449852 |mesh-terms=* Accelerometry * Adult * Aged * Aging * Electroencephalography * Evoked Potentials * Exercise Test * Female * Gait * Humans * Male * Middle Aged * Multitasking Behavior * Reaction Time * Walking |keywords=* Dual task * EEG * Gait cycle * Gait related potentials (GRP) |full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110709 }} ==APOC3== {{medline-entry |title=Positional Obstructive Sleep Apnea Syndrome in Elderly Patients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32050596 |mesh-terms=* Adult * Aged * Humans * Middle Aged * Polysomnography * Posture * Prospective Studies * Sleep Apnea, Obstructive * Supine Position * Young Adult |keywords=* aging effects * obstructive sleep apnea * polysomnography * positional sleep apnea |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042812 }} ==APOE== {{medline-entry |title=Polygenic risk score of longevity predicts longer survival across an age-continuum. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33216869 |keywords=* centenarians * cognitive health * genetics * healthy aging * longevity |full-text-url=https://sci-hub.do/10.1093/gerona/glaa289 }} {{medline-entry |title=Association Between [[APOE]] Alleles and Change of Neuropsychological Tests in the Long Life Family Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33216038 |keywords=* APOE * cognition * longevity * longitudinal studies |full-text-url=https://sci-hub.do/10.3233/JAD-201113 }} {{medline-entry |title=The [[APOE]] gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33215813 |keywords=* Alzheimer's disease * aging * air pollution * apolipoprotein E * chromosome 19q13 |full-text-url=https://sci-hub.do/10.1002/alz.12230 }} {{medline-entry |title=Homozygosity in the [i][[APOE]][/i] 3 Polymorphism Is Associated With Less Depression and Higher Serum Low-Density Lipoprotein in Chinese Elderly Schizophrenics. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33178131 |keywords=* APOE E3 * Chinese * aging * depressive symptom * schizophrenia |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593819 }} {{medline-entry |title=Effect of apolipoprotein E polymorphism on cognition and brain in the Cambridge Centre for Ageing and Neuroscience cohort. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33088920 |keywords=* Cognition * ageing * apolipoprotein E * brain * lifespan |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545750 }} {{medline-entry |title=Cardiovascular risk factors and [[APOE]]-ε4 status affect memory functioning in aging via changes to temporal stem diffusion. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33070365 |keywords=* APOE * BMI * RRID:SCR_001398 * RRID:SCR_002403 * RRID:SCR_002823 * RRID:SCR_002865 * RRID:SCR_007037 * aging * diffusion tensor imaging * hypertension * memory * path modeling |full-text-url=https://sci-hub.do/10.1002/jnr.24734 }} {{medline-entry |title=[[APOE]] [i]ε[/i]4 and resting-state functional connectivity in racially/ethnically diverse older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32999914 |keywords=* APOE ε4 differences * brain aging * dementia * neuroimaging * racial/ethnic differences * resting‐state functional connectivity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508460 }} {{medline-entry |title=Predictors of Olfactory Decline in Aging: A Longitudinal Population-Based Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32886741 |keywords=* Cognitive aging * Epidemiology * Olfactory * Olfactory impairment |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662159 }} {{medline-entry |title=When Culture Influences Genes: Positive Age Beliefs Amplify the Cognitive-Aging Benefit of [[APOE]] ε2. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32835364 |keywords=* APOE * Age beliefs * Cognition * Gene * Health and Retirement Study * Self-perceptions of aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489069 }} {{medline-entry |title=Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32817639 |mesh-terms=* Adult * Aged * Aged, 80 and over * Aging * Alzheimer Disease * Apolipoprotein E4 * Biomarkers * Case-Control Studies * Cohort Studies * Female * Genotype * Humans * Male * Middle Aged |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446786 }} {{medline-entry |title=Estimating the potential for dementia prevention through modifiable risk factors elimination in the real-world setting: a population-based study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32767997 |keywords=* Aging * Alzheimer’s disease * Dementia * Dementia prevention * Modifiable risk factors * Population attributable fraction * Public health |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414752 }} {{medline-entry |title=Machine learning-based estimation of cognitive performance using regional brain MRI markers: the Northern Manhattan Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32740887 |keywords=* Biomarkers * Brain aging * Cognitive aging * Machine learning |full-text-url=https://sci-hub.do/10.1007/s11682-020-00325-3 }} {{medline-entry |title=Effects of an [[APOE]] Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32694990 |keywords=* APOE promoter * aging * brain connectome * fronto-parietal network * working memory |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338603 }} {{medline-entry |title=The relationship of parental longevity with the aging brain-results from UK Biobank. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32671621 |keywords=* Aging * Brain structure * DTI * MRI * Neuroimaging * Parental longevity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525531 }} {{medline-entry |title=Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32610143 |keywords=* Alzheimer’s disease * aging * microglia * neurodegenerative diseases * neuroinflammation * transcriptomics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422733 }} {{medline-entry |title=Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer's Disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32474467 |keywords=* APOEɛ4 * Aging * Alzheimer’s disease * gender * lipid species |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369125 }} {{medline-entry |title=Effects of sex, age, and apolipoprotein E genotype on hippocampal parenchymal fraction in cognitively normal older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32416384 |mesh-terms=* Age Factors * Aged * Aged, 80 and over * Apolipoproteins E * Biomarkers * Cognition * Databases, Factual * Female * Genotype * Hippocampus * Humans * Linear Models * Male * Middle Aged * Neuroimaging * Organ Size * Parenchymal Tissue * Reference Values * Sex Factors |keywords=* Alzheimer’s disease * Apolipoprotein E ϵ4 * Atrophy * Brain * Healthy aging * Hippocampal parenchymal fraction * Hippocampal volumetric integrity * Hippocampus * MRI * Mild cognitive impairment * Neurodegeneration * Sex |full-text-url=https://sci-hub.do/10.1016/j.pscychresns.2020.111107 }} {{medline-entry |title=Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32380778 |keywords=* Cilento Region * cognitive health * lifestyle * longevity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279440 }} {{medline-entry |title=Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32342099 |keywords=* Aging * Alzheimer’s disease * Apolipoprotein E * Cognition * Cognitive frailty * Frailty * Male |full-text-url=https://sci-hub.do/10.1093/gerona/glaa105 }} {{medline-entry |title=CSF amyloid is a consistent predictor of white matter hyperintensities across the disease course from aging to Alzheimer's disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32305782 |mesh-terms=* Aged * Aged, 80 and over * Aging * Alzheimer Disease * Amyloid beta-Peptides * Biomarkers * Cerebrovascular Disorders * Cognitive Dysfunction * Female * Humans * Magnetic Resonance Imaging * Male * Peptide Fragments * White Matter * tau Proteins |keywords=* Alzheimer's disease * Amyloid * Cerebrospinal fluid * Tau * Vascular disease * White matter hyperintensities |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.03.008 }} {{medline-entry |title=Association of Cardiovascular Risk Factors with Cerebral Perfusion in Whites and African Americans. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32310160 |keywords=* Aging * Alzheimer’s disease * blood pressure * cerebrovascular circulation * neuroimaging * obesity |full-text-url=https://sci-hub.do/10.3233/JAD-190360 }} {{medline-entry |title=Alzheimer's Risk Factors Age, [[APOE]] Genotype, and Sex Drive Distinct Molecular Pathways. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32199103 |mesh-terms=* Adaptor Proteins, Signal Transducing * Age Factors * Aging * Alzheimer Disease * Animals * Apolipoprotein E2 * Apolipoprotein E3 * Apolipoprotein E4 * Apolipoproteins E * Brain * Female * Gene Expression * Gene Expression Profiling * Gene Regulatory Networks * Genotype * Humans * Male * Membrane Glycoproteins * Membrane Proteins * Metabolome * Mice * Mice, Transgenic * Protective Factors * Receptors, Immunologic * Risk Factors * Serpins * Sex Factors * Unfolded Protein Response |keywords=* APOE * Alzheimer’s disease * Serpina3 * age * extracellular vesicles * inflammation * lipid metabolism * metabolomics * sex * transcriptomics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388065 }} {{medline-entry |title=Less agreeable, better preserved? A PET amyloid and MRI study in a community-based cohort. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32169357 |mesh-terms=* Aged * Aged, 80 and over * Amyloidogenic Proteins * Apolipoproteins E * Brain * Cognition * Cohort Studies * Female * Follow-Up Studies * Humans * Magnetic Resonance Imaging * Male * Neuroimaging * Organ Size * Personality * Positron-Emission Tomography |keywords=* Amyloid load * Cognitive aging * Cohort studies * Personality * Structural MRI |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.02.004 }} {{medline-entry |title=Physical Activity as Moderator of the Association Between [[APOE]] and Cognitive Decline in Older Adults: Results from Three Longitudinal Cohort Studies. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32110803 |keywords=* Gene–environment interaction * InCHIANTI * Longitudinal Aging Study Amsterdam * Rotterdam Study |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518558 }} {{medline-entry |title=Longitudinal Maintenance of Cognitive Health in Centenarians in the 100-plus Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32101309 |mesh-terms=* Aged, 80 and over * Aging * Apolipoprotein E4 * Cognition * Female * Humans * Longitudinal Studies * Male * Mental Status and Dementia Tests * Prospective Studies |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137688 }} {{medline-entry |title=Interaction of [[APOE]], cerebral blood flow, and cortical thickness in the entorhinal cortex predicts memory decline. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32048144 |keywords=* APOE ε4 * Aging * Cerebral blood flow * Cognitive decline * Cortical thickness |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165062 }} {{medline-entry |title=Determinants of mesial temporal lobe volume loss in older individuals with preserved cognition: a longitudinal PET amyloid study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32057528 |mesh-terms=* Aged * Aged, 80 and over * Aging * Alleles * Amyloidogenic Proteins * Apolipoprotein E4 * Cognitive Reserve * Female * Follow-Up Studies * Genotype * Humans * Longitudinal Studies * Male * Neuropsychological Tests * Organ Size * Positron-Emission Tomography * Sex Factors * Temporal Lobe |keywords=* APOE * Amyloid load * Cognitive changes * Mesial temporal lobe * Normal aging * Structural MRI |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2019.12.002 }} {{medline-entry |title=Long-term exposure to ambient air pollution, [[APOE]]-ε4 status, and cognitive decline in a cohort of older adults in northern Manhattan. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31926436 |mesh-terms=* Aged * Air Pollutants * Air Pollution * Apolipoprotein E4 * Apolipoproteins E * Cognitive Dysfunction * Female * Genotype * Humans * Male * Prospective Studies * Washington |keywords=* APOE-ε4 allele * Aging * Air pollution * Cognitive decline * Cognitive risk factors * Epidemiology |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024003 }} {{medline-entry |title=Evidence in support of chromosomal sex influencing plasma based metabolome vs [[APOE]] genotype influencing brain metabolome profile in humanized [[APOE]] male and female mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31917799 |mesh-terms=* Age of Onset * Aging * Alzheimer Disease * Amyloid beta-Peptides * Animals * Apolipoprotein E4 * Apolipoproteins E * Brain * Disease Models, Animal * Female * Genotype * Humans * Magnetic Resonance Imaging * Male * Metabolome * Mice * Mice, Transgenic * Sex Characteristics * Sex Chromosomes |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952084 }} {{medline-entry |title=[[APOE]] region molecular signatures of Alzheimer's disease across races/ethnicities. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31813627 |mesh-terms=* Alleles * Alzheimer Disease * Apolipoproteins E * Continental Population Groups * Haplotypes * Heterozygote * Homozygote * Humans * Linkage Disequilibrium * Polymorphism, Single Nucleotide * Risk Factors |keywords=* APOE polymorphism * Aging * Alzheimer's disease * Health span * Life span * Neurodegenerative disorders |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064423 }} {{medline-entry |title=Varying Effects of [[APOE]] Alleles on Extreme Longevity in European Ethnicities. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31724059 |mesh-terms=* Aged, 80 and over * Alleles * Apolipoproteins E * Ethnic Groups * Europe * European Continental Ancestry Group * Female * Humans * Longevity * Male |keywords=* APOE * Bioinformatics * Human genetics * Longevity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330482 }} {{medline-entry |title=Prospective Evaluation of Cognitive Health and Related Factors in Elderly at Risk for Developing Alzheimer's Dementia: A Longitudinal Cohort Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31686098 |mesh-terms=* Aged * Aged, 80 and over * Alzheimer Disease * Anxiety * Apolipoprotein E4 * Cognition * Cognitive Dysfunction * Cohort Studies * Depression * Efficiency * Female * Healthy Volunteers * Humans * Longitudinal Studies * Male * Mental Status and Dementia Tests * Middle Aged * Neuropsychological Tests * Prospective Studies * Risk Factors * Sleep * United Kingdom * Work |keywords=* Alzheimer Disease * CHARIOT * aging registry * cognitive health * pre-clinical |full-text-url=https://sci-hub.do/10.14283/jpad.2019.31 }} {{medline-entry |title=Association of Cardiovascular and Alzheimer's Disease Risk Factors with Intracranial Arterial Blood Flow in Whites and African Americans. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31658057 |mesh-terms=* African Americans * Aged * Alzheimer Disease * Biomarkers * Blood Flow Velocity * Cardiovascular Diseases * Cerebrovascular Circulation * European Continental Ancestry Group * Female * Humans * Male * Middle Aged * Risk Factors |keywords=* African Americans * Alzheimer’s disease * Apolipoprotein E4 * aging * cerebrovascular circulation * glucose * metabolic syndrome * neuroimaging * risk factors |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081660 }} {{medline-entry |title=Is Ongoing Anticholinergic Burden Associated With Greater Cognitive Decline and Dementia Severity in Mild to Moderate Alzheimer's Disease? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31613323 |keywords=* Alzheimers * Cognitive aging * Drug related * Medication |full-text-url=https://sci-hub.do/10.1093/gerona/glz244 }} {{medline-entry |title=Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31630996 |mesh-terms=* Age Factors * Aged * Aged, 80 and over * Alzheimer Disease * Amyloid * Biomarkers * Cohort Studies * Europe * Female * Humans * Inflammation * Male * Middle Aged * Parkinson Disease * Sex Factors * tau Proteins |keywords=* Aging * Alzheimer's disease * Amyloid * Biomarker * Cerebrospinal fluid * Inflammation * Mild cognitive impairment * Multicenter * Parkinson's disease * Tau |full-text-url=https://sci-hub.do/10.1016/j.jalz.2019.07.018 }} {{medline-entry |title=Prospective Memory: Age related change is influenced by [[APOE]] genotype. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31578124 |keywords=* APOE * Alzheimer’s disease * aging * mid-adulthood * prospective memory |full-text-url=https://sci-hub.do/10.1080/13825585.2019.1671305 }} {{medline-entry |title=Education Moderates the Relation Between [[APOE]] ɛ4 and Memory in Nondemented Non-Hispanic Black Older Adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31594222 |mesh-terms=* Adult * African Americans * Aged * Aged, 80 and over * Aging * Alzheimer Disease * Apolipoprotein E4 * Cognitive Reserve * Educational Status * Executive Function * Female * Humans * Male * Memory * Memory, Episodic * Memory, Short-Term * Middle Aged * Neuropsychological Tests * Sex Characteristics |keywords=* APOE * African American * Alzheimer’s disease * cognitive reserve * educational attainment * episodic memory * genetic risk * neuropsychological evaluation |full-text-url=https://sci-hub.do/10.3233/JAD-190415 }} {{medline-entry |title=Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31561966 |mesh-terms=* Age Factors * Aged * Alleles * Apolipoprotein E4 * Cognition Disorders * European Continental Ancestry Group * Executive Function * Female * Humans * Longitudinal Studies * Male * Memory * Neuropsychological Tests * Sex Factors |keywords=* Aging * Alzheimer's disease * Apolipoprotein E ε4 * Cognitive decline * Sex |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561018 }} {{medline-entry |title=Interactive effect of age and [[APOE]]-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31520917 |mesh-terms=* Age Factors * Aged * Aging * Apolipoprotein E4 * Female * Humans * Magnetic Resonance Imaging * Male * Middle Aged * Myelin Sheath * White Matter |keywords=* Aging * Alzheimer * Apolipoprotein E * Cognitively normal subjects * Myelination * T1w/T2w ratio * White matter integrity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742967 }} {{medline-entry |title=[[APOE]] modifies the interaction of entorhinal cerebral blood flow and cortical thickness on memory function in cognitively normal older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31493534 |mesh-terms=* Aged * Aged, 80 and over * Apolipoproteins E * Cerebral Cortex * Cerebrovascular Circulation * Entorhinal Cortex * Female * Genotype * Humans * Linear Models * Male * Memory * Middle Aged |keywords=* APOE ε4 * Aging * Alzheimer’s disease * Cerebral blood flow * Cognitive decline * Cortical thickness |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819270 }} {{medline-entry |title=When time's arrow doesn't bend: [[APOE]]-ε4 influences episodic memory before old age. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31473197 |mesh-terms=* Adult * Alleles * Alzheimer Disease * Apolipoprotein E4 * Cognition * Cognitive Aging * Female * Genotype * Humans * Linear Models * Male * Memory * Memory, Episodic * Middle Aged * Young Adult |keywords=* Alzheimer's diseas * Apolipoprotein E * Cognition * Episodic memory * Semantic memory |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817416 }} {{medline-entry |title=Cognitive-Motor Integration Performance Is Affected by Sex, [[APOE]] Status, and Family History of Dementia. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31424400 |mesh-terms=* Aged * Apolipoproteins E * Cognition * Cognitive Dysfunction * Cross-Sectional Studies * Dementia * Female * Humans * Male * Medical History Taking * Middle Aged * Photic Stimulation * Psychomotor Performance * Sex Characteristics * Surveys and Questionnaires |keywords=* Aging * alzheimer’s disease * apolipoprotein E4 * dementia risk * geriatric assessment * motor skills * movement * visuomotor integration |full-text-url=https://sci-hub.do/10.3233/JAD-190403 }} {{medline-entry |title=Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31437719 |mesh-terms=* Aged * Aged, 80 and over * Aging * Amyloid beta-Peptides * Atrophy * Brain * Cognition * Cognitive Dysfunction * Databases, Factual * Female * Humans * Longitudinal Studies * Male * Middle Aged |keywords=* Aging * Alzheimer's disease * Amyloid-β * Brain atrophy |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198229 }} {{medline-entry |title=Cognitive function and neuropathological outcomes: a forward-looking approach. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31435771 |mesh-terms=* Aged * Aged, 80 and over * Aging * Alzheimer Disease * Cognitive Dysfunction * Female * Humans * Male * Middle Aged |keywords=* Alzheimer’s disease * Cognition * Multi-state model * Neuropathology |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851487 }} {{medline-entry |title=[[APOE]] gene-dependent BOLD responses to a breath-hold across the adult lifespan. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31408838 |mesh-terms=* Adult * Aged * Aging * Apolipoprotein E3 * Apolipoprotein E4 * Apolipoproteins E * Breath Holding * Cerebrovascular Circulation * Cross-Over Studies * Double-Blind Method * Female * Genotype * Hemodynamics * Humans * Longevity * Magnetic Resonance Imaging * Male * Middle Aged * Nitrates |keywords=* Ageing * Alzheimer's disease * Apolipoprotein E * BOLD fMRI * Breath-hold * Cerebrovascular reactivity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699560 }} ==APP== {{medline-entry |title=Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32917871 |mesh-terms=* Aging * Alzheimer Disease * Amyloid beta-Peptides * Animals * Behavior, Animal * Cognitive Dysfunction * Cytokines * Dipeptides * Disease Models, Animal * Encephalitis * Female * Humans * Inflammation * Male * Memory Disorders * Mice * Mice, Inbred C57BL * Mice, Transgenic * Serpins * Spatial Memory * Viral Proteins * para-Aminobenzoates |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486940 }} {{medline-entry |title=Regorafenib Regulates AD Pathology, Neuroinflammation, and Dendritic Spinogenesis in Cells and a Mouse Model of AD. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32660121 |keywords=* aging * amyloid beta * dendritic spine * neuroinflammation * regorafenib * tau |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408082 }} {{medline-entry |title=An agnostic reevaluation of the amyloid cascade hypothesis of Alzheimer's disease pathogenesis: The role of [[APP]] homeostasis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32588983 |keywords=* aging * amyloid hypothesis * amyloid precursor protein homeostasis * late onset Alzheimer's disease * young onset Alzheimer's disease |full-text-url=https://sci-hub.do/10.1002/alz.12124 }} {{medline-entry |title=Transcriptomic profiling of microglia and astrocytes throughout aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32238175 |keywords=* Aging * Alzheimer’s disease (AD) * Astrocyte * Microglia * RNA-seq |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115095 }} {{medline-entry |title=Platelets in Amyloidogenic Mice Are Activated and Invade the Brain. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32194368 |keywords=* Alzheimer’s disease * aging * astrocytes * platelets * vascular pathology |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063083 }} {{medline-entry |title=CHIP modulates [[APP]]-induced autophagy-dependent pathological symptoms in Drosophila. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31777182 |mesh-terms=* Alzheimer Disease * Amyloid beta-Protein Precursor * Animals * Aspartic Acid Endopeptidases * Autophagy * Brain * Cognitive Dysfunction * Disease Models, Animal * Dopaminergic Neurons * Down-Regulation * Drosophila * Drosophila Proteins * Eye * Learning Disabilities * Locomotion * Longevity * Nuclear Proteins * Presenilins * RNA Interference * Wings, Animal |keywords=* CHIP * APP * Alzheimer’s disease * Aβ * autophagy |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996943 }} {{medline-entry |title=Studies on [[APP]] metabolism related to age-associated mitochondrial dysfunction in [[APP]]/PS1 transgenic mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31744937 |mesh-terms=* Adenosine Triphosphate * Aging * Alzheimer Disease * Amyloid beta-Protein Precursor * Animals * Blood Platelets * Disease Models, Animal * Hippocampus * Mice * Mice, Inbred C57BL * Mice, Transgenic * Mitochondria * Presenilin-1 |keywords=* APP/PS1 mice * Amyloid-beta * adenosine 5’-triphosphate * mitochondria dysfunction * platelets |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914425 }} {{medline-entry |title=Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer's Disease in Patients with Mild Cognitive Impairment: A Pilot Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31671598 |mesh-terms=* Aged * Alzheimer Disease * Biomarkers * Case-Control Studies * Cognition * Cognitive Dysfunction * Female * Humans * Hyperoxia * Hypoxia * Male * Middle Aged * Pilot Projects * Respiratory Therapy * Treatment Outcome |keywords=* Alzheimer’s disease * adaptation * aging * amyloid beta * biomarker * cognitive function * hyperoxia * intermittent hypoxia * platelets |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862463 }} {{medline-entry |title=The Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive Dysfunction |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31677609 |mesh-terms=* Adult * Aged * Aged, 80 and over * Aging * Alzheimer Disease * Amyloid Precursor Protein Secretases * Amyloid beta-Peptides * Androgens * Aspartic Acid Endopeptidases * Cognition * Cognitive Dysfunction * Cyclic AMP Response Element-Binding Protein * Female * Hippocampus * Humans * Learning * MAP Kinase Signaling System * Male * Middle Aged * Neoplasm Proteins * Phosphorylation * Protein Kinase C * Receptors for Activated C Kinase * tau Proteins |keywords=* Androgens * Cognition * Hippocampus * Protein kinase C * Spatial memory |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984714 }} {{medline-entry |title=Modulation of Neural and Muscular Adaptation Processes During Resistance Training by Fish Protein Ingestions in Older Adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31596471 |keywords=* Aging * Alaska pollack protein * Motor unit identification * Multichannel surface electromyography * Nutritional supplementation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164534 }} {{medline-entry |title=Antipsychotic Polypharmacy in Older Adult Asian Patients With Schizophrenia: Research on Asian Psychotropic Prescription Pattern. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31480982 |mesh-terms=* Aged * Aged, 80 and over * Aging * Antipsychotic Agents * Asian Continental Ancestry Group * Female * Humans * Male * Middle Aged * Polypharmacy * Schizophrenia |keywords=* Asian * antipsychotic polypharmacy * older adult patients * schizophrenia |full-text-url=https://sci-hub.do/10.1177/0891988719862636 }} {{medline-entry |title=A pleiotropic role for exosomes loaded with the amyloid β precursor protein carboxyl-terminal fragments in the brain of Down syndrome patients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31479861 |mesh-terms=* Amyloid beta-Protein Precursor * Brain * Down Syndrome * Exosomes * Humans |keywords=* APP * APP-CTFs * Aging * Brain * Down syndrome * Exosomes * Extracellular vesicles |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960325 }} ==APPL1== {{medline-entry |title=Insulin and adipokine signaling and their cross-regulation in postmortem human brain. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31539648 |mesh-terms=* Adipokines * Aging * Brain * Humans * Insulin * Leptin * Postmortem Changes * Signal Transduction |keywords=* Adipokine * Adiponectin receptors * Alzheimer's disease–related dementias * Leptin receptors * Postmortem brain * Type 2 diabetes * insulin signaling |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960343 }} ==AQP3== {{medline-entry |title=Transbuccal platform for delivery of lipogenic actives to facial skin: Because fat matters. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32592290 |keywords=* adipocytes * aging * cosmetics * face * fat pads * integument * subcutis * wrinkles |full-text-url=https://sci-hub.do/10.1002/term.3087 }} ==AR== {{medline-entry |title=Mechanisms of Androgen Receptor Agonist- and Antagonist-Mediated Cellular Senescence in Prostate Cancer. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32650419 |keywords=* PKB/Akt * Src * androgen receptor antagonist * antiandrogen * bipolar androgen therapy * cellular senescence * prostate cancer * supraphysiological androgen levels |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408918 }} {{medline-entry |title=Interleukin-23 Represses the Level of Cell Senescence Induced by the Androgen Receptor Antagonists Enzalutamide and Darolutamide in Castration-Resistant Prostate Cancer Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32562083 |keywords=* Androgen receptor antagonists * Cellular senescence * Interleukin-23 * Prostate cancer spheroids |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335377 }} {{medline-entry |title=A Landscape of Murine Long Non-Coding RNAs Reveals the Leading Transcriptome Alterations in Adipose Tissue during Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32460027 |keywords=* adipocyte * adipose tissue * aging * lncRNA * long non-coding RNA * non-coding RNA * transcriptome |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603645 }} {{medline-entry |title=Senolytic compounds control a distinct fate of androgen receptor agonist- and antagonist-induced cellular senescent LNCaP prostate cancer cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32351687 |keywords=* Akt inhibitor * Antiandrogen * Bcl-2 family inhibitor * Bipolar androgen therapy * Cellular senescence * HSP90 inhibitor * Prostate cancer * Senolytic compounds |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183592 }} {{medline-entry |title=Role of gut microbiota in sex- and diet-dependent metabolic disorders that lead to early mortality of androgen receptor-deficient male mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32017595 |mesh-terms=* Adipocytes * Adipose Tissue * Animals * Anti-Bacterial Agents * Diet * Diet, High-Fat * Feces * Female * Gastrointestinal Microbiome * Lipid Metabolism * Longevity * Male * Metabolic Diseases * Mice * Mice, Inbred C57BL * Mice, Knockout * Obesity * Receptors, Androgen * Sex Characteristics |keywords=* androgen-insensitive syndrome * longevity * metabolic syndrome * testosterone * type 2 diabetes |full-text-url=https://sci-hub.do/10.1152/ajpendo.00461.2019 }} {{medline-entry |title=A jaboticaba extract prevents prostatic damage associated with aging and high-fat diet intake. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32003372 |mesh-terms=* Aging * Animals * Cell Proliferation * Diet, High-Fat * Male * Mice * Myrtaceae * Plant Extracts * Prostate |full-text-url=https://sci-hub.do/10.1039/c9fo02621e }} {{medline-entry |title=Identifying blood-specific age-related DNA methylation markers on the Illumina MethylationEPIC® BeadChip. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31546163 |mesh-terms=* Adolescent * Adult * Aged * Aged, 80 and over * Aging * Child * Child, Preschool * Cohort Studies * CpG Islands * DNA Methylation * Forensic Genetics * Genetic Markers * Humans * Infant * Infant, Newborn * Linear Models * Middle Aged * Oligonucleotide Array Sequence Analysis * Young Adult |keywords=* Age * CpG sites * DNA methylation * Forensic age estimation * Forensic epigenetics * Illumina MethylationEPIC |full-text-url=https://sci-hub.do/10.1016/j.forsciint.2019.109944 }} ==ARC== {{medline-entry |title=The Polymorphism rs2968 of [i]LSS[/i] Gene Confers Susceptibility to Age-Related Cataract. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32877255 |mesh-terms=* Aged * Aging * Alleles * Cataract * Female * Gene Expression Regulation * Genetic Association Studies * Genetic Predisposition to Disease * Genotype * Haplotypes * Humans * Hydroxymethylglutaryl CoA Reductases * Intramolecular Transferases * Lens, Crystalline * Male * Middle Aged * Polymorphism, Single Nucleotide |keywords=* ARC * HMGCR * LSS * SNPs * lanosterol |full-text-url=https://sci-hub.do/10.1089/dna.2020.5872 }} {{medline-entry |title=Decreased Anti-Müllerian hormone and Anti-Müllerian hormone receptor type 2 in hypothalami of old Japanese Black cows. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32554955 |keywords=* Müllerian inhibiting substance * female reproductive senescence * gonadotropin-releasing hormone neuron * preoptic area * ruminant |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468072 }} {{medline-entry |title=Resveratrol delay the cataract formation against naphthalene-induced experimental cataract in the albino rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31746523 |mesh-terms=* Animals * Cataract * Dose-Response Relationship, Drug * Male * Naphthalenes * Rats * Rats, Sprague-Dawley * Resveratrol |keywords=* age-related cataracts * aging * oxidative stress * resveratrol |full-text-url=https://sci-hub.do/10.1002/jbt.22420 }} ==AREG== {{medline-entry |title=Targeting amphiregulin ([[AREG]]) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31493351 |mesh-terms=* Amphiregulin * Animals * Antineoplastic Agents * B7-H1 Antigen * Cells, Cultured * Cellular Senescence * Drug Resistance, Neoplasm * Humans * Mice * Mice, Inbred NOD * Mice, SCID * Stromal Cells * Tumor Microenvironment |keywords=* aging * amphiregulin * cancer resistance * clinical biomarker * combinational treatment * programmed cell death 1 ligand * senescence-associated secretory phenotype * stroma |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826133 }} ==ARNT== {{medline-entry |title=Loss of [[ARNT]] in skeletal muscle limits muscle regeneration in aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33064329 |keywords=* aging * hypoxia signaling * muscle regeneration |full-text-url=https://sci-hub.do/10.1096/fj.202000761RR }} {{medline-entry |title=[Arylhydrocarbon receptor nuclear translocator ([[ARNT]]) in human skin during aging.] |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32593246 |mesh-terms=* Adolescent * Adult * Aged * Aged, 80 and over * Aging * Aryl Hydrocarbon Receptor Nuclear Translocator * Child * Child, Preschool * Dermis * Fetus * Fibroblasts * Humans * Infant * Infant, Newborn * Skin * Skin Aging * Young Adult |keywords=* ARNT * PCNA * aging * fibroblasts * skin }} {{medline-entry |title=The E3 ubiquitin ligase STUB1 attenuates cell senescence by promoting the ubiquitination and degradation of the core circadian regulator BMAL1. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32041778 |keywords=* E3 ubiquitin ligase * STIP1 homology and U-box-containing protein 1 (STUB1) * brain and muscle ARNT-like 1 (BMAL1, ARNTL, MOP3) * cell cycle regulation * circadian clock * hydrogen peroxide * proteasome * protein degradation * senescence * ubiquitylation (ubiquitination) |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135990 }} ==ASB7== {{medline-entry |title=[[ASB7]] Is a Novel Regulator of Cytoskeletal Organization During Oocyte Maturation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33251222 |keywords=* ASBs * maternal aging * meiosis * oocyte * reproduction |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674779 }} ==ASL== {{medline-entry |title=Increased blood-brain barrier permeability to water in the aging brain detected using noninvasive multi-TE [[ASL]] MRI. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32910547 |keywords=* aging * aquaporin-4 * arterial spin labeling * blood-brain barrier * blood-brain interface * water permeability |full-text-url=https://sci-hub.do/10.1002/mrm.28496 }} {{medline-entry |title=Quantitative Cerebrovascular Reactivity in Normal Aging: Comparison Between Phase-Contrast and Arterial Spin Labeling MRI. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32849217 |keywords=* MRI * aging * arterial spin labeling * cerebrovascular reactivity * phase-contrast |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7411174 }} {{medline-entry |title=Correcting Task fMRI Signals for Variability in Baseline CBF Improves BOLD-Behavior Relationships: A Feasibility Study in an Aging Model. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32425745 |keywords=* BOLD deactivation * aging * cerebral blood flow * domain-general * language fMRI * semantic fluency * sensitization |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205008 }} ==ASXL1== {{medline-entry |title=[[ASXL1]] mutation in clonal hematopoiesis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31945396 |mesh-terms=* Aged * Aging * Animals * Clonal Evolution * Codon, Nonsense * Hematologic Neoplasms * Hematopoiesis * Humans * Myeloproliferative Disorders * Neoplasm Proteins * Repressor Proteins |full-text-url=https://sci-hub.do/10.1016/j.exphem.2020.01.002 }} ==ATF4== {{medline-entry |title=Endoplasmic Reticulum Stress Mediates Vascular Smooth Muscle Cell Calcification via Increased Release of Grp78-Loaded Extracellular Vesicles. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33297752 |keywords=* aging * arteries * endoplasmic reticulum * vascular calcification * warfarin |full-text-url=https://sci-hub.do/10.1161/ATVBAHA.120.315506 }} ==ATF6== {{medline-entry |title=Cellular proteostasis decline in human senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33257563 |keywords=* UPR * chaperones * heat shock response * protein homeostasis * senescence |full-text-url=https://sci-hub.do/10.1073/pnas.2018138117 }} {{medline-entry |title=Impact of endoplasmic reticulum stress on oocyte aging mechanisms. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32514562 |keywords=* ER stress * GRP78 * PERK * eIF2α * endoplasmic reticulum * mouse oocyte * oocyte aging * salubrinal |full-text-url=https://sci-hub.do/10.1093/molehr/gaaa040 }} {{medline-entry |title=ER stress activates immunosuppressive network: implications for aging and Alzheimer's disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32279085 |keywords=* Ageing * Immunometabolism * Immunosenescence * Immunosuppression * Inflammaging * Neurodegeneration |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220864 }} {{medline-entry |title=Towards Age-Related Anti-Inflammatory Therapy: Klotho Suppresses Activation of ER and Golgi Stress Response in Senescent Monocytes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31972978 |keywords=* ER stress response * Golgi apparatus/complex stress response * SASP * immunosenescence * klotho * monocytes |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072557 }} ==ATG3== {{medline-entry |title=Estrogen Signaling Induces Mitochondrial Dysfunction-Associated Autophagy and Senescence in Breast Cancer Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32244623 |keywords=* Estrogen * MCF-7 * MDA-MB-231 * autophagy * mitochondria * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235898 }} ==ATG5== {{medline-entry |title=Autophagy and heat-shock response impair stress granule assembly during cellular senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33049246 |keywords=* Ageing * Cellular senescence * Molecular biology * Oxidative stress * Stress granules |full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111382 }} ==ATG7== {{medline-entry |title=Age-related impairment of autophagy in cervical motor neurons. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33290859 |keywords=* Aging * Autophagy * Motor neuron * Neuromuscular dysfunction * Spinal cord |full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111193 }} {{medline-entry |title=Comprehensive Bioinformatics Identifies Key microRNA Players in [[ATG7]]-Deficient Lung Fibroblasts. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32527064 |keywords=* autophagy * bioinformatics * functional network analysis * lung fibrosis * miR * proteomics * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312768 }} {{medline-entry |title=Regulation of autophagy by DNA G-quadruplexes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32420812 |keywords=* G-quadruplex * aging * astrocytes * autophagy * neurodegeneration * neurons |full-text-url=https://sci-hub.do/10.1080/15548627.2020.1769991 }} {{medline-entry |title=[[ATG7]] is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31880208 |keywords=* ATG7 * Aging * ameloblast * autophagy * epithelium * ferritin * hyperplasia * iron * secretion * tooth |full-text-url=https://sci-hub.do/10.1080/15548627.2019.1709764 }} {{medline-entry |title=Enhancing Autophagy Diminishes Aberrant Ca Homeostasis and Arrhythmogenesis in Aging Rabbit Hearts. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31636573 |keywords=* aging * autophagy * calcium * cardiac physiology * ryanodine receptor |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787934 }} ==ATM== {{medline-entry |title=S[[ATM]]F Suppresses the Premature Senescence Phenotype of the [[ATM]] Loss-of-Function Mutant and Improves Its Fertility in [i]Arabidopsis[/i]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143308 |keywords=* ATM * DNA damage * SATMF * fertility * leaf senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662627 }} {{medline-entry |title=[[ATM]] mediated-p53 signaling pathway forms a novel axis for senescence control. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32949791 |keywords=* ATM inhibition * Metabolic reprogrammer * Mitochondria * P53 * Senescence alleviation |full-text-url=https://sci-hub.do/10.1016/j.mito.2020.09.002 }} {{medline-entry |title=Non-canonical [[ATM]]/MRN activities temporally define the senescence secretory program. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32785991 |keywords=* DNA damage response * MRN complex * NF-κB * chromatin * senescence secretome |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534619 }} {{medline-entry |title=[[ATM]] is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32201398 |keywords=* ATM * DNA damage response * NF-κB * aging * cellular senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138542 }} {{medline-entry |title=[[ATM]] suppresses leaf senescence triggered by DNA double-strand break through epigenetic control of senescence-associated genes in Arabidopsis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32163596 |keywords=* Arabidopsis thaliana * ATM * DNA repair * double-strand breaks * histone methylation * leaf senescence |full-text-url=https://sci-hub.do/10.1111/nph.16535 }} {{medline-entry |title=Glioblastoma Cells Do Not Affect Axitinib-Dependent Senescence of HUVECs in a Transwell Coculture Model. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32098270 |mesh-terms=* Ataxia Telangiectasia Mutated Proteins * Axitinib * Cell Line, Tumor * Cellular Senescence * Coculture Techniques * Gene Expression Profiling * Glioblastoma * Human Umbilical Vein Endothelial Cells * Humans * Phosphorylation |keywords=* Axitinib * endothelial cells * glioblastoma * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073100 }} {{medline-entry |title=Declining BRCA-Mediated DNA Repair in Sperm Aging and its Prevention by Sphingosine-1-Phosphate. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31916095 |keywords=* Aging * DNA fragmentation * Gene expression * Sperm |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065969 }} {{medline-entry |title=BRCA-related [[ATM]]-mediated DNA double-strand break repair and ovarian aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31822904 |mesh-terms=* Aging * Animals * Ataxia Telangiectasia * BRCA1 Protein * BRCA2 Protein * DNA Breaks, Double-Stranded * DNA Repair * Female * Fertility * Fertility Preservation * Humans * Mice * Oocytes * Ovarian Follicle * Ovarian Reserve * Ovary |keywords=* BRCA * BRCA1/2 * DNA repair * anti-Mullerian hormone * chemotherapy * mutations * oocyte * ovarian aging * ovarian reserve * ovarian response |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935693 }} {{medline-entry |title=[[ATM]] Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31781094 |mesh-terms=* Anti-Retroviral Agents * Ataxia Telangiectasia Mutated Proteins * Cellular Senescence * DNA Damage * HIV Infections * Humans * T-Lymphocytes * Telomere |keywords=* ATM * DNA damage repair * HIV * T cell homeostasis * apoptosis * immune aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856652 }} {{medline-entry |title=SMG1 heterozygosity exacerbates haematopoietic cancer development in Atm null mice by increasing persistent DNA damage and oxidative stress. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31565865 |mesh-terms=* Animals * Ataxia Telangiectasia Mutated Proteins * Carcinogenesis * Cells, Cultured * DNA Damage * Embryo, Mammalian * Fibroblasts * Gamma Rays * Hematologic Neoplasms * Heterozygote * Kaplan-Meier Estimate * Longevity * Lymphoma * Mice, Inbred C57BL * Mice, Knockout * Oxidative Stress * Protein-Serine-Threonine Kinases |keywords=* DNA damage * cancer * inflammation * lymphoma * oxidative stress |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850945 }} {{medline-entry |title=LncRNA RP11-670E13.6, interacted with hnRNPH, delays cellular senescence by sponging microRNA-663a in UVB damaged dermal fibroblasts. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31444317 |mesh-terms=* Cell Proliferation * Cellular Senescence * Fibroblasts * Heterogeneous-Nuclear Ribonucleoprotein Group F-H * Humans * MicroRNAs * RNA, Long Noncoding * Skin * Skin Aging * Ultraviolet Rays |keywords=* cellular senescence * dermal fibroblast * lncRNA * microRNA * ultraviolet B |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738423 }} {{medline-entry |title=Tel1/[[ATM]] Signaling to the Checkpoint Contributes to Replicative Senescence in the Absence of Telomerase. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31391264 |mesh-terms=* Amino Acid Substitution * Ataxia Telangiectasia Mutated Proteins * Cell Cycle Checkpoints * Cell Division * Cellular Senescence * DNA Damage * DNA Replication * DNA, Single-Stranded * DNA-Binding Proteins * Intracellular Signaling Peptides and Proteins * Mutant Proteins * Protein-Serine-Threonine Kinases * Saccharomyces cerevisiae * Saccharomyces cerevisiae Proteins * Telomerase * Telomere * Telomere Shortening |keywords=* Tel1 * checkpoint * replicative senescence * telomere |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781906 }} ==ATP7A== {{medline-entry |title=Adipocyte-specific disruption of ATPase copper transporting α in mice accelerates lipoatrophy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31396659 |mesh-terms=* 3T3-L1 Cells * Adipocytes * Adipose Tissue, White * Aging * Animals * Body Weight * Copper * Copper-Transporting ATPases * Diet, High-Fat * Energy Metabolism * Insulin Resistance * Lipid Metabolism * Lipodystrophy * Lipolysis * Mice * Mice, Knockout |keywords=* ATP7A * Adipose tissues * Copper * Insulin resistance * Lipoatrophy |full-text-url=https://sci-hub.do/10.1007/s00125-019-4966-2 }} ==ATR== {{medline-entry |title=Bloodstain age estimation through infrared spectroscopy and Chemometric models. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33077037 |keywords=* Aging * Bloodstains * Chemometric * Forensic chemistry * MLR * PLSR |full-text-url=https://sci-hub.do/10.1016/j.scijus.2020.07.004 }} {{medline-entry |title=Artificial Intelligence and fourier-transform infrared spectroscopy for evaluating water-mediated degradation of lubricant oils. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32887052 |keywords=* ANN * Artificial neural networks * FTIR * LDA * Linear discriminant analysis * Lubricant oil aging |full-text-url=https://sci-hub.do/10.1016/j.talanta.2020.121312 }} {{medline-entry |title=Senescence Induction by Combined Ionizing Radiation and DNA Damage Response Inhibitors in Head and Neck Squamous Cell Carcinoma Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32883016 |keywords=* ATM * ATR * DNA damage response inhibitor * DNAPK * HNSCC * homologous recombination * ionizing radiation * kinase inhibitor * radiosensitivity * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563880 }} {{medline-entry |title=Kinetics of thermal degradation and lifetime study of poly(vinylidene fluoride) (PVDF) subjected to bioethanol fuel accelerated aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32775731 |keywords=* Activation energy * Aging * Bioethanol fuel * Kinetics analysis * Lifetime prediction * Materials chemistry * Materials science * Poly(vinylidene fluoride) |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398943 }} {{medline-entry |title=Supraphysiological protection from replication stress does not extend mammalian lifespan. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32253367 |keywords=* DNA damage * aging * cancer * mouse models * replication stress |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185120 }} {{medline-entry |title=Assessing the Retest Reliability of Prefrontal EEG Markers of Brain Rhythm Slowing in the Eyes-Closed Resting State. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32253926 |keywords=* EEG * EEG slowing * brain aging * dominant frequency * prefrontal |full-text-url=https://sci-hub.do/10.1177/1550059420914832 }} {{medline-entry |title=Effects of Hydrogen Peroxide and Sodium Hypochlorite Aging on Properties and Performance of Polyethersulfone Ultrafiltration Membrane. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31635217 |mesh-terms=* Humic Substances * Hydrogen Peroxide * Hydrophobic and Hydrophilic Interactions * Membranes, Artificial * Polymers * Sodium Hypochlorite * Sulfones * Ultrafiltration |keywords=* chemical cleaning * hydrogen peroxide (H2O2) * membrane aging * polyethersulfone (PES) ultrafiltration (UF) membrane * sodium hypochlorite (NaClO) |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843545 }} {{medline-entry |title=NF-κB signaling in skin aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31634486 |mesh-terms=* Animals * Cellular Senescence * Humans * NF-kappa B * Phenotype * Signal Transduction * Skin Aging * Skin Neoplasms |keywords=* NF-κB * Senescence-associated secretory phenotype * Skin aging |full-text-url=https://sci-hub.do/10.1016/j.mad.2019.111160 }} {{medline-entry |title=Development of a w/o emulsion using ionic liquid strategy for transdermal delivery of anti - aging component α - lipoic acid: Mechanism of different ionic liquids on skin retention and efficacy evaluation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31634554 |mesh-terms=* Administration, Cutaneous * Animals * Emulsions * Hydroxyproline * Ionic Liquids * Male * Rats, Wistar * Skin * Skin Absorption * Skin Aging * Thioctic Acid * Ultraviolet Rays |keywords=* Anti – aging efficacy * Ionic liquids * Skin retention * Solubility * Α – lipoic acid |full-text-url=https://sci-hub.do/10.1016/j.ejps.2019.105042 }} {{medline-entry |title=Effect of Nitrogen-Doped Graphene Oxide on the Aging Behavior of Nitrile-Butadiene Rubber. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31658636 |keywords=* aging resistance * graphene oxide * nitrile-butadiene rubber * nitrogen-doped |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835680 }} ==AVP== {{medline-entry |title=Plasma oxytocin and vasopressin levels in young and older men and women: Functional relationships with attachment and cognition. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31606581 |mesh-terms=* Adolescent * Adult * Age Factors * Aged * Aged, 80 and over * Aging * Anxiety * Avoidance Learning * Cognition * Cohort Studies * Female * Humans * Male * Middle Aged * Object Attachment * Oxytocin * Sex Factors * Vasopressins * Young Adult |keywords=* Age * Attachment anxiety * Oxytocin * Processing speed * Sex * Vasopressin |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943921 }} ==B4GALT1== {{medline-entry |title=Expression of β-1,4-galactosyltransferases during Aging in Caenorhabditis elegans. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33171474 |keywords=* Biomarker * Glycosylation * Lifespan regulation * bre-4 * sqv-3 |full-text-url=https://sci-hub.do/10.1159/000510722 }} ==BACE1== {{medline-entry |title=Electric Stimulation of Neurogenesis Improves Behavioral Recovery After Focal Ischemia in Aged Rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32742258 |keywords=* aging * behavior * electrical stimulation * neurogenesis * rats * stroke |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365235 }} {{medline-entry |title=Disruption of synaptic expression pattern and age-related DNA oxidation in a neuronal model of lead-induced toxicity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32058320 |keywords=* Aging mice * Brain-derived neurotrophic factor precursor * Latent expression pattern * Lead * Pubertal exposure * Synaptic deficits * Tau phosphorylation |full-text-url=https://sci-hub.do/10.1016/j.etap.2020.103350 }} ==BAD== {{medline-entry |title=I imidazoline receptor modulation protects aged SAMP8 mice against cognitive decline by suppressing the calcineurin pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33128688 |keywords=* Aging * Alzheimer’s disease * Behavior * I2 imidazoline receptors * NFAT * Neuroinflammation * Neuroprotection |full-text-url=https://sci-hub.do/10.1007/s11357-020-00281-2 }} ==BAK1== {{medline-entry |title=Developmental Attenuation of Neuronal Apoptosis by Neural-Specific Splicing of Bak1 Microexon. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32710818 |mesh-terms=* Animals * Apoptosis * Brain * Cell Line, Tumor * Cells, Cultured * Female * Heterogeneous-Nuclear Ribonucleoproteins * Male * Mice * Mice, Inbred C57BL * Mutation * Neural Stem Cells * Neurogenesis * Nonsense Mediated mRNA Decay * Polypyrimidine Tract-Binding Protein * RNA Splicing * bcl-2 Homologous Antagonist-Killer Protein |keywords=* AS-NMD * BAK * BCL2 family proteins * NMD * PTB * PTBP * PTBP2 * UPF2 * alternative splicing * cell death * neural development * neurogenesis * neuronal lifespan |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529960 }} ==BANF1== {{medline-entry |title=An additional case of Néstor-Guillermo progeria syndrome diagnosed in early childhood. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32783369 |keywords=* BANF1 * Néstor-Guillermo progeria syndrome * premature aging * progeria * whole exome sequencing |full-text-url=https://sci-hub.do/10.1002/ajmg.a.61777 }} ==BATF== {{medline-entry |title=LncRNA-ES3 inhibition by Bhlhe40 is involved in high glucose-induced calcification/senescence of vascular smooth muscle cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32483833 |keywords=* Bhlhe40 * VSMC calcification/senescence * diabetes * lncRNA-ES3 * microRNA * vascular aging |full-text-url=https://sci-hub.do/10.1111/nyas.14381 }} ==BAX== {{medline-entry |title=Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-X -[[BAX]] interaction. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32652830 |keywords=* ABT-263 * BCL-XL * chemotherapy * radiation * senescence * senolytic |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7530780 }} {{medline-entry |title=CREB Signaling Mediates Dose-Dependent Radiation Response in the Murine Hippocampus Two Years after Total Body Exposure. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31657930 |keywords=* CREB signaling * aging * brain * hippocampus * ionizing radiation * label-free proteomics |full-text-url=https://sci-hub.do/10.1021/acs.jproteome.9b00552 }} ==BAZ2B== {{medline-entry |title=Two conserved epigenetic regulators prevent healthy ageing. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32103178 |mesh-terms=* Aging * Animals * Caenorhabditis elegans * Caenorhabditis elegans Proteins * Cognition * Cognitive Dysfunction * Epigenesis, Genetic * Healthy Aging * Histone-Lysine N-Methyltransferase * Histones * Humans * Longevity * Lysine * Male * Memory * Methylation * Mice * Mitochondria * Neurons * Proteins * RNA Interference * Spatial Learning * Transcription Factors, General |full-text-url=https://sci-hub.do/10.1038/s41586-020-2037-y }} ==BCL6== {{medline-entry |title=Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32452837 |keywords=* Adaptive immunity * Aging * Cellular senescence * T cells * Vaccines |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324201 }} ==BCR== {{medline-entry |title=The presence of CLL-associated stereotypic B cell receptors in the normal [[BCR]] repertoire from healthy individuals increases with age. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31485252 |keywords=* Aging * B-lymphocyte * BCR repertoire * CLL * Stereotypic BCR |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714092 }} ==BDNF== {{medline-entry |title=Influence of [i][[BDNF]][/i] Genetic Polymorphisms in the Pathophysiology of Aging-related Diseases. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33269104 |keywords=* Aging * BDNF gene * aging-related diseases * polymorphism |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673859 }} {{medline-entry |title=Moderators of the Impact of (Poly)Phenols Interventions on Psychomotor Functions and [[BDNF]]: Insights from Subgroup Analysis and Meta-Regression. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32961777 |keywords=* aging * antioxidant * brain functions * brain plasticity * cognition * psychomotor functions |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551086 }} {{medline-entry |title=Astroglia-Derived [[BDNF]] and MSK-1 Mediate Experience- and Diet-Dependent Synaptic Plasticity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32708382 |keywords=* AMPA receptors * Arc/Arg3.1 * GABA receptors * TrkB receptors * aging * calcium signalling * dendritic spines * diet * enriched environment * glia-neuron interactions * ion conductance microscopy * synaptic scaling * synaptic strength |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407492 }} {{medline-entry |title=[[BDNF]] reverses aging-related microglial activation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32664974 |keywords=* Aging * BDNF * CREB * Microglial activation * NF-кB * TrkB |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362451 }} {{medline-entry |title=High Supervised Resistance Training in Elderly Women: The Role of Supervision Ratio. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32509119 |keywords=* Aging * exercise * functional capacity * muscle strength |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241618 }} {{medline-entry |title=Metformin regulates astrocyte reactivity in Parkinson's disease and normal aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32497590 |keywords=* Aging * Dorsal striatum * Metformin * Parkinson's disease * Reactive astrocyte |full-text-url=https://sci-hub.do/10.1016/j.neuropharm.2020.108173 }} {{medline-entry |title=Aging-Induced Brain-Derived Neurotrophic Factor in Adipocyte Progenitors Contributes to Adipose Tissue Dysfunction. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32489703 |keywords=* BDNF * adipocyte progenitors * adipose tissue * aging * sympathetic innervation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220283 }} {{medline-entry |title=The Role of [[BDNF]] on Aging-Modulation Markers. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32397504 |keywords=* BBB * astrocytes * brain aging * in vivo model * low dose BDNF |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287884 }} {{medline-entry |title=Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32268299 |keywords=* aging * autophagy * mitochondrial dysfunction * polyamine |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185103 }} {{medline-entry |title=Microglia senescence occurs in both substantia nigra and ventral tegmental area. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32275335 |keywords=* Parkinson's disease * aging-dependent neurodegeneration * dopamine neurons * microglia complexity * stereological analyses * tyrosine hydroxylase; microglia senescence |full-text-url=https://sci-hub.do/10.1002/glia.23834 }} {{medline-entry |title=Towards an understanding of the physical activity-[[BDNF]]-cognition triumvirate: A review of associations and dosage. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32171785 |mesh-terms=* Aging * Brain-Derived Neurotrophic Factor * Cognition * Exercise * Healthy Aging * Humans |keywords=* Ageing * BDNF * Brain * Physical activity |full-text-url=https://sci-hub.do/10.1016/j.arr.2020.101044 }} {{medline-entry |title=Impact of [[BDNF]] and sex on maintaining intact memory function in early midlife. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31948671 |mesh-terms=* Brain * Brain-Derived Neurotrophic Factor * Cognition * Female * Humans * Magnetic Resonance Imaging * Male * Memory * Memory, Short-Term * Menopause * Middle Aged * Neuroprotective Agents * Neuropsychological Tests * Reproduction * Sex Characteristics |keywords=* Aging * BDNF * Hormones * Memory * Menopause * Sex differences |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2019.12.014 }} {{medline-entry |title=Testosterone replacement causes dose-dependent improvements in spatial memory among aged male rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31901624 |keywords=* Aging * BDNF * Object location memory * Radial arm maze * Spatial memory * Testosterone |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080566 }} {{medline-entry |title=The effects of aerobic exercise intensity on memory in older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31665610 |keywords=* BDNF * activité physique * aging * cognition * entraînement par intervalles de haute intensité * executive functions * exercice * exercise * fonctions exécutives * high-intensity interval training * memory * mémoire * physical activity * vieillissement |full-text-url=https://sci-hub.do/10.1139/apnm-2019-0495 }} {{medline-entry |title=Protective effects of vitamin D on neurophysiologic alterations in brain aging: role of brain-derived neurotrophic factor ([[BDNF]]). |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31524100 |keywords=* BDNF * Brain aging * neurophysiologic alterations * neuroprotection * vitamin D supplementation |full-text-url=https://sci-hub.do/10.1080/1028415X.2019.1665854 }} {{medline-entry |title=Differential Effects of Physical Exercise, Cognitive Training, and Mindfulness Practice on Serum [[BDNF]] Levels in Healthy Older Adults: A Randomized Controlled Intervention Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31498125 |mesh-terms=* Aged * Brain-Derived Neurotrophic Factor * Cognition * Correlation of Data * Exercise * Female * Healthy Aging * Healthy Lifestyle * Humans * Learning * Male * Mindfulness * Neuropsychological Tests * Outcome Assessment, Health Care |keywords=* Aging * brain-derived neurotrophic factor * cognitive training * mindfulness * physical exercise |full-text-url=https://sci-hub.do/10.3233/JAD-190756 }} {{medline-entry |title=Dietary Supplementation with Fish Oil or Conjugated Linoleic Acid Relieves Depression Markers in Mice by Modulation of the Nrf2 Pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31398773 |mesh-terms=* Aging * Animals * Antidepressive Agents * Autoimmunity * Biomarkers * Brain * Brain-Derived Neurotrophic Factor * Depression * Dietary Supplements * Docosahexaenoic Acids * Fatty Acid Elongases * Fatty Acids * Fish Oils * Inflammation * Linoleic Acids, Conjugated * Liver * Male * Mice, Inbred MRL lpr * NF-E2-Related Factor 2 * Oxidative Stress * Stearoyl-CoA Desaturase * Tumor Necrosis Factor-alpha |keywords=* brain derived neurotrophic factor * brain fatty acid profile * conjugated linoleic acid * depression * fish oil * nuclear erythroid related factor-2 |full-text-url=https://sci-hub.do/10.1002/mnfr.201900243 }} ==BGN== {{medline-entry |title=Alterations of local functional connectivity in lifespan: A resting-state fMRI study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32462815 |keywords=* four-dimensional spatial-temporal consistency of local neural activity * lifespan * local functional connectivity * local functional connectivity density * resting-state fMRI |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375100 }} ==BHLHE40== {{medline-entry |title=Thyroid hormone induces cellular senescence in prostate cancer cells through induction of DEC1. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32360904 |mesh-terms=* Basic Helix-Loop-Helix Transcription Factors * Cell Line, Tumor * Cell Proliferation * Cellular Senescence * Cyclin-Dependent Kinase Inhibitor p15 * Homeodomain Proteins * Humans * Male * Prostatic Neoplasms * Thyroid Hormones |keywords=* BHLHE40 * Cellular senescence * DEC1 * Prostate cancer * Thyroid hormone |full-text-url=https://sci-hub.do/10.1016/j.jsbmb.2020.105689 }} ==BLM== {{medline-entry |title=[Olmesartan inhibits age-associated migration and invasion of human aortic vascular smooth muscle cells by upregulating miR-3133 axis]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32895132 |mesh-terms=* Cell Movement * Cell Proliferation * Cells, Cultured * Humans * Imidazoles * Matrix Metalloproteinase 2 * MicroRNAs * Muscle, Smooth, Vascular * Myocytes, Smooth Muscle * Tetrazoles |keywords=* aging * invasion * microRNA * migration * olmesartan * vascular smooth muscle cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225100 }} ==BMI1== {{medline-entry |title=Senescence Induced by [[BMI1]] Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33086074 |keywords=* BH3 mimetics * BMI1 * DIPG * H3K27M mutant * H3WT * PTC 028 * RNAi screen * SASP * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574900 }} ==BMP2== {{medline-entry |title=Interleukin-1β-Induced Senescence Promotes Osteoblastic Transition of Vascular Smooth Muscle Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32126555 |mesh-terms=* Adult * Aged * Aged, 80 and over * Female * Humans * Interleukin-1beta * Male * Middle Aged * Muscle, Smooth, Vascular * Osteoblasts |keywords=* Interleukin-1β * Osteoblastic transition * Senescence * Vascular calcification |full-text-url=https://sci-hub.do/10.1159/000504298 }} ==BMP4== {{medline-entry |title=Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32896271 |keywords=* aging * direct reprogramming * endothelial cell * human * hutchinson-gilford progeria syndrome * medicine * mouse * smooth muscle cell * vascular barrier |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478891 }} ==BMP7== {{medline-entry |title=Downregulation of miR-542-3p promotes osteogenic transition of vascular smooth muscle cells in the aging rat by targeting [[BMP7]]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31829291 |mesh-terms=* Aging * Animals * Base Sequence * Bone Morphogenetic Protein 7 * Down-Regulation * Glycerophosphates * MicroRNAs * Models, Biological * Muscle, Smooth, Vascular * Myocytes, Smooth Muscle * Osteogenesis * Rats |keywords=* Aging * Mir-542-3p * Osteogenic differentiation * Vascular smooth muscle cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6907335 }} ==BOC== {{medline-entry |title=Protein Requirements of Elderly Chinese Adults Are Higher than Current Recommendations. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32140711 |mesh-terms=* Aged * Aging * Amino Acids * Body Weight * China * Dietary Proteins * Energy Intake * Energy Metabolism * Female * Humans * Male * Nutritional Requirements * Oxidation-Reduction * Phenylalanine * Recommended Dietary Allowances * Tyrosine |keywords=* indicator amino acid oxidation * older adults * phenylalanine oxidation * protein requirement * stable isotope |full-text-url=https://sci-hub.do/10.1093/jn/nxaa031 }} ==BPI== {{medline-entry |title=High TARC plasma levels confer protection to long living individuals by inducing M2 profile. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33002742 |keywords=* FACS * Longevity * M2 macrophages * Plasma profile * TARC |full-text-url=https://sci-hub.do/10.1016/j.cyto.2020.155305 }} {{medline-entry |title=Circulating [[BPI]]FB4 Levels Associate With and Influence the Abundance of Reparative Monocytes and Macrophages in Long Living Individuals. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32547549 |keywords=* FACS * M2 macrophages * immunity * longevity * patrolling-monocytes * plasma |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272600 }} ==BPIFB4== {{medline-entry |title=New Insights for [[BPIFB4]] in Cardiovascular Therapy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32998388 |keywords=* BPIFB4 * aging * cardiovascular disease |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7583974 }} {{medline-entry |title=LAV-[[BPIFB4]] associates with reduced frailty in humans and its transfer prevents frailty progression in old mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31461407 |mesh-terms=* Aged * Aged, 80 and over * Aging * Animals * Female * Frailty * Gene Expression Regulation * Genotype * Humans * Longevity * Male * Mice * Mice, Inbred C57BL * Mice, Transgenic * Phosphoproteins * Specific Pathogen-Free Organisms |keywords=* BPIFB4 * aging * frailty * longevity-associated variant-lav * survival |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738439 }} ==BRAF== {{medline-entry |title=Conditional reprograming culture conditions facilitate growth of lower grade glioma models. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33258947 |keywords=* BRAFV600E * Conditional reprogramming * NF1 * Senescence * low grade glioma |full-text-url=https://sci-hub.do/10.1093/neuonc/noaa263 }} {{medline-entry |title=Active notch protects MAPK activated melanoma cell lines from MEK inhibitor cobimetinib. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33202284 |keywords=* Cobimetinib (PubChem CID: 16222096) * MEK * Nirogacestat (PubChem CID:46224413) * Notch * Senescence * Uveal melanoma |full-text-url=https://sci-hub.do/10.1016/j.biopha.2020.111006 }} {{medline-entry |title=Mitochondrial metabolic reprograming via [[BRAF]] inhibition ameliorates senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31421186 |mesh-terms=* Cell Proliferation * Cells, Cultured * Cellular Reprogramming * Cellular Senescence * Drug Evaluation, Preclinical * Humans * Mitochondria * Proto-Oncogene Proteins B-raf |keywords=* BRAF * Metabolic reprogramming * Mitochondrial function * SB590885 * Senescence |full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110691 }} ==BRD2== {{medline-entry |title=Brd2 haploinsufficiency extends lifespan and healthspan in C57B6/J mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32559200 |mesh-terms=* Animals * Female * Fertility * Grooming * Haploinsufficiency * Kidney * Longevity * Male * Mice * Mice, Inbred C57BL * Transcription Factors |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304595 }} ==BRD4== {{medline-entry |title=Inhibition of [[BRD4]] triggers cellular senescence through suppressing aurora kinases in oesophageal cancer cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32954665 |keywords=* BRD4 * aurora kinase * cellular senescence * oesophageal cancer |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701500 }} {{medline-entry |title=[[BRD4]] contributes to LPS-induced macrophage senescence and promotes progression of atherosclerosis-associated lipid uptake. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32392533 |keywords=* BRD4 * gene expression * inflammation * macrophage * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288959 }} {{medline-entry |title=BET Proteins Are Required for Transcriptional Activation of the Senescent Islet Cell Secretome in Type 1 Diabetes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31561444 |mesh-terms=* Animals * Cell Cycle Proteins * Cellular Senescence * Diabetes Mellitus, Type 1 * Female * Humans * Insulin-Secreting Cells * Islets of Langerhans * Mice * Mice, Inbred NOD * Paracrine Communication * Protein Binding * Transcription Factors * Transcriptional Activation |keywords=* BET proteins * beta cells * senescence and SASP * type 1 diabetes |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801956 }} ==BTK== {{medline-entry |title=Amelioration of age-related brain function decline by Bruton's tyrosine kinase inhibition. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31736210 |keywords=* BTK * cellular senescence * healthspan * p53 * progeria |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974713 }} ==C2== {{medline-entry |title=[Effects of resistance training on mitochondrial function in skeletal muscle of aging rats]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32744013 |mesh-terms=* Aging * Animals * Male * Membrane Potential, Mitochondrial * Mitochondria, Muscle * Muscle, Skeletal * Physical Conditioning, Animal * Rats * Rats, Sprague-Dawley * Resistance Training |keywords=* fusion protein 2 * mitochondria * quadriceps * rats * resistance training |full-text-url=https://sci-hub.do/10.12047/j.cjap.5861.2020.037 }} {{medline-entry |title=Structural and functional characterization of Solanum lycopersicum phosphatidylinositol 3-kinase [[C2]] domain. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31972387 |mesh-terms=* Animals * C2 Domains * Lycopersicon esculentum * Phosphatidylinositol 3-Kinase * Plants, Genetically Modified * Protein Binding * Tobacco |keywords=* C2 domain * Membrane binding * Phosphatidylinositol 3-kinase * Senescence |full-text-url=https://sci-hub.do/10.1016/j.plaphy.2020.01.014 }} ==C3== {{medline-entry |title=Inverse association between periumbilical fat and longevity mediated by complement [[C3]] and cardiac structure. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33221761 |keywords=* abdominal obesity * cardiac structure * complement C3 * longevity * periumbilical fat |full-text-url=https://sci-hub.do/10.18632/aging.104113 }} {{medline-entry |title=Complement [[C3]] deficiency ameliorates aging related changes in the kidney. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32882264 |mesh-terms=* Aging * Animals * Complement C3 * Inflammation * Kidney * Kidney Diseases * Male * Mice * Mice, Inbred C57BL * Mice, Knockout |keywords=* Complement component 3 * Kidney disorder * Senescence |full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118370 }} {{medline-entry |title=Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32087947 |mesh-terms=* Aging * Animals * Brain * Homeostasis * Immunity, Innate * Mice, Transgenic * Neurons * Racemases and Epimerases * Sialic Acid Binding Immunoglobulin-like Lectins * Sialic Acids * Synapses |keywords=* Aging * GNE * Glycocalyx * Microglia * Neurodegeneration * Neuroinflammation * Sialic acid |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.01.008 }} {{medline-entry |title=[Comparative analysis of experimental data about the effects of various polyphenols on lifespan and aging.] |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31512417 |mesh-terms=* Animals * Antioxidants * Female * Longevity * Male * Mice * Mice, Inbred BALB C * Polyphenols * Survival Analysis |keywords=* BP-C3 * Gompertz model * SkQ1 * aging * herbal extracts * lifespan * metformin * polyphenols * resveratrol * tocopherol }} ==C5== {{medline-entry |title=The [[C5]]-75 Program: Meeting the Need for Efficient, Pragmatic Frailty Screening and Management in Primary Care. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32638663 |keywords=* aging * case-finding * co-morbid conditions * comorbidité * dépistage * fragilité * frailty * primary care * recherche de cas * screening * soins de première ligne * vieillissement |full-text-url=https://sci-hub.do/10.1017/S0714980820000161 }} {{medline-entry |title=Can a relatively large spinal cord for the dural sac influence severity of paralysis in elderly patients with cervical spinal cord injury caused by minor trauma? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32590805 |mesh-terms=* Aged * Aged, 80 and over * Cervical Vertebrae * Female * Geriatrics * Humans * Japan * Magnetic Resonance Imaging * Male * Paralysis * Severity of Illness Index * Spinal Canal * Spinal Cord * Spinal Cord Injuries * Tomography, X-Ray Computed * Wounds and Injuries |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328921 }} ==C6== {{medline-entry |title=Evolution of the Aroma of Treixadura Wines during Bottle Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33049919 |keywords=* bottle aging * flavor profile * sensory evaluation * volatile composition * white wine |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600726 }} {{medline-entry |title=D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32991321 |keywords=* CDK6 * D-galatose * YAP * cellular senescence * glioblastoma |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585072 }} ==C7== {{medline-entry |title=The Vertebral Artery Convergence to the Cervical Spine in Elders. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32337923 |mesh-terms=* Aged * Aged, 80 and over * Aging * Cervical Vertebrae * Computed Tomography Angiography * Cross-Sectional Studies * Female * Humans * Male * Middle Aged * Retrospective Studies * Vertebral Artery |keywords=* angiography * computed tomography * osteoarthritis * spine * vertebral artery * aging |full-text-url=https://sci-hub.do/10.3897/folmed.61.e39418 }} ==C9== {{medline-entry |title=[[C9]]orf72 in myeloid cells suppresses STING-induced inflammation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32814898 |mesh-terms=* Aging * Amyotrophic Lateral Sclerosis * Animals * C9orf72 Protein * Dendritic Cells * Encephalomyelitis, Autoimmune, Experimental * Female * Humans * Inflammation * Interferon Type I * Membrane Proteins * Mice * Myeloid Cells * Neoplasms * T-Lymphocytes |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484469 }} {{medline-entry |title=Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31843021 |mesh-terms=* Aging * Alanine * Animals * Animals, Genetically Modified * Brain * C9orf72 Protein * DNA Repeat Expansion * Dipeptides * Drosophila * Female * Glycine |keywords=* Ageing * C9orf72 * Dipeptide repeat proteins * Drosophila * PolyGA * Repeat size * Spread |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916080 }} {{medline-entry |title=Human iPSC-derived astrocytes from ALS patients with mutated [[C9]]ORF72 show increased oxidative stress and neurotoxicity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31787569 |mesh-terms=* Amyotrophic Lateral Sclerosis * Animals * Astrocytes * Biomarkers * C9orf72 Protein * Cells, Cultured * Cellular Reprogramming * Cellular Senescence * Cerebral Cortex * Disease Models, Animal * Gene Expression Profiling * Glutamic Acid * Humans * Induced Pluripotent Stem Cells * Mice * Motor Neurons * Mutation * Oxidative Stress * Proteomics * Reactive Oxygen Species |keywords=* Amyotrophic lateral sclerosis * Astrocytes * Neurotoxicity * Oxidative stress * Senescence * iPSC |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921360 }} ==C9orf72== {{medline-entry |title=Carriership of two copies of [[C9orf72]] hexanucleotide repeat intermediate-length alleles is a risk factor for ALS in the Finnish population. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33168078 |keywords=* ALS * Aging * C9orf72 * Case-control analysis * Intermediate repeats |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7654028 }} ==CA1== {{medline-entry |title=The relation between tau pathology and granulovacuolar degeneration of neurons. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33069844 |keywords=* AT8 * Aging * CA1 * Casein kinase 1δ * Congo red * Dorsal raphe nucleus * Locus coeruleus * Neurodegeneration * Tau pathology |full-text-url=https://sci-hub.do/10.1016/j.nbd.2020.105138 }} {{medline-entry |title=Memory and dendritic spines loss, and dynamic dendritic spines changes are age-dependent in the rat. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32950615 |keywords=* Aging * Hippocampus * Locomotor activity * Memory and learning * Prefrontal cortex * Pyramidal neurons * dendritic spines |full-text-url=https://sci-hub.do/10.1016/j.jchemneu.2020.101858 }} {{medline-entry |title=Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32887666 |keywords=* Amyotrophic lateral sclerosis (ALS) * C9ORF72 * Dentate gyrus, adult neurogenesis * Frontotemporal dementia (FTD) * Klotho * Long-term depression (LTD) * Long-term potentiation (LTP) * Longevity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473815 }} {{medline-entry |title=COX5A Plays a Vital Role in Memory Impairment Associated With Brain Aging [i]via[/i] the BDNF/ERK1/2 Signaling Pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32754029 |keywords=* BDNF * COX5A * ERK1/2 * brain senescence * memory impairment * mitochondria |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365906 }} {{medline-entry |title=Changes of fat-mass and obesity-associated protein expression in the hippocampus in animal models of high-fat diet-induced obesity and D-galactose-induced aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32647628 |keywords=* Aging * Fto * Hippocampus * Mice * Obesity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336480 }} {{medline-entry |title=Phenylbutyrate ameliorates prefrontal cortex, hippocampus, and nucleus accumbens neural atrophy as well as synaptophysin and GFAP stress in aging mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32531811 |keywords=* aging * dendrites * hippocampus * memory and learning * nucleus accumbens * prefrontal cortex * sodium phenylbutyrate |full-text-url=https://sci-hub.do/10.1002/syn.22177 }} {{medline-entry |title=Heterogeneity in brain distribution of activated microglia and astrocytes in a rat ischemic model of Alzheimer's disease after 2 years of survival. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32501292 |keywords=* Alzheimer’s disease * aging * brain ischemia * glia * neuroinflammation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343500 }} {{medline-entry |title=Hippocampal Subregion Transcriptomic Profiles Reflect Strategy Selection during Cognitive Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32376783 |mesh-terms=* Animals * Cognitive Aging * Dentate Gyrus * Hippocampus * Maze Learning * Rats * Rats, Inbred F344 * Spatial Memory * Transcriptome |keywords=* aging * hippocampus * pattern separation * reference memory * spatial discrimination * transcription |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326352 }} {{medline-entry |title=Associations between pattern separation and hippocampal subfield structure and function vary along the lifespan: A 7 T imaging study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32371923 |mesh-terms=* Adult * Age Factors * Aged * Brain Mapping * Female * Hippocampus * Humans * Longevity * Magnetic Resonance Imaging * Male * Middle Aged * Young Adult |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200747 }} {{medline-entry |title=Laminarin Pretreatment Provides Neuroprotection against Forebrain Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Neuroinflammation in Aged Gerbils. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32326571 |keywords=* aging * laminarin * neuroinflammation * neuroprotection * oxidative stress * transient cerebral ischemia |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230782 }} {{medline-entry |title=Age-dependent Alteration in Mitochondrial Dynamics and Autophagy in Hippocampal Neuron of Cannabinoid CB1 Receptor-deficient Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32294520 |keywords=* Aging * CB1 receptor * Hippocampus * Mitochondria * Mitophagy |full-text-url=https://sci-hub.do/10.1016/j.brainresbull.2020.03.014 }} {{medline-entry |title=Functional Connectivity of Hippocampal CA3 Predicts Neurocognitive Aging via [[CA1]]-Frontal Circuit. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32239141 |keywords=* aging * functional connectivity * hippocampus * spatial memory |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325802 }} {{medline-entry |title=Integration of qRT-PCR and Immunohistochemical Techniques for mRNA Expression and Localization of m1AChR in the Brain of Aging Rat. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32219760 |keywords=* Acetylcholine * Aging * Brain * Immunohistochemistry * m1AChR * qRT-PCR |full-text-url=https://sci-hub.do/10.1007/978-1-0716-0471-7_23 }} {{medline-entry |title=Role of Eclipta prostrata extract in improving spatial learning and memory deficits in D-galactose-induced aging in rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32186114 |mesh-terms=* Aging * Animals * Behavior, Animal * CA1 Region, Hippocampal * Catalase * Dopamine * Eclipta * Galactose * Gene Expression Regulation, Enzymologic * Glutathione Peroxidase * Glutathione Reductase * Male * Memory Disorders * Nitric Oxide * Nitric Oxide Synthase Type II * Norepinephrine * Plant Extracts * RNA, Messenger * Rats * Rats, Sprague-Dawley * Serotonin * Spatial Learning * Superoxide Dismutase |keywords=* Antioxidants * Eclipta * Galactose * Memory disorders * Spatial learning }} {{medline-entry |title=Differential annualized rates of hippocampal subfields atrophy in aging and future Alzheimer's clinical syndrome. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32107063 |mesh-terms=* Aged * Aging * Alzheimer Disease * Atrophy * Cohort Studies * Cross-Sectional Studies * Dentate Gyrus * Female * Hippocampus * Humans * Magnetic Resonance Imaging * Male * Neuropsychological Tests * Risk |keywords=* Aging * Alzheimer's disease * Hippocampal subfields * MRI |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.01.011 }} {{medline-entry |title=Rectification of radiotherapy-induced cognitive impairments in aged mice by reconstituted Sca-1 stem cells from young donors. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32028989 |mesh-terms=* Animals * Behavior, Animal * Cognitive Dysfunction * Dendritic Spines * Hematopoietic Stem Cell Transplantation * Hippocampus * Humans * Long-Term Potentiation * Maze Learning * Memory * Mice * Neurons * Radiotherapy * Recovery of Function * Spinocerebellar Ataxias * Treatment Outcome |keywords=* Aging * Bone marrow stem cells * Learning and memory * Microglia * Radiotherapy |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006105 }} {{medline-entry |title=Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31919362 |mesh-terms=* Aging * Animals * Cyclin D1 * Cyclin-Dependent Kinase 4 * Female * Hippocampus * Learning * Memory * Memory Consolidation * Mice * Mice, Inbred C57BL * Neural Stem Cells * Neurogenesis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952376 }} {{medline-entry |title=Memory Performance Correlates of Hippocampal Subfield Volume in Mild Cognitive Impairment Subtype. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31849620 |keywords=* aging * hippocampus * memory * mild cognitive impairment * neuroimaging * subfields |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897308 }} {{medline-entry |title=Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31873156 |mesh-terms=* Aging * Animals * CA3 Region, Hippocampal * Long-Term Potentiation * Mice * Mossy Fibers, Hippocampal * Spermidine * Synaptic Transmission * Synaptic Vesicles |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927957 }} {{medline-entry |title=Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31843022 |mesh-terms=* Aging * Animals * Caspase 6 * Caspase Inhibitors * Cognitive Dysfunction * Female * Humans * Inflammation * Male * Methylene Blue * Mice * Mice, Inbred C57BL * Mice, Knockout * Mice, Transgenic |keywords=* Alzheimer disease * Axonal degeneration * Caspase-6 * Caspase-6 inhibitor * Hippocampal CA1 * Hippocampal fibres * Methylene blue * Synaptic plasticity * White matter |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915996 }} {{medline-entry |title=Long-term Memory Upscales Volume of Postsynaptic Densities in the Process that Requires Autophosphorylation of αCaMKII. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31800021 |keywords=* CA1 area * CaMKII * IntelliCages * aging * dendritic spines * memory * postsynaptic density |full-text-url=https://sci-hub.do/10.1093/cercor/bhz261 }} {{medline-entry |title=PACAP27 mitigates an age-dependent hippocampal vulnerability to PGJ2-induced spatial learning deficits and neuroinflammation in mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31769222 |keywords=* CA1 * CA3 * Fluoro-Jade C * aging * microglia * radial arm maze |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955932 }} {{medline-entry |title=Inhibition of oxidative stress by testosterone improves synaptic plasticity in senescence accelerated mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31746286 |mesh-terms=* Aging * Animals * Male * Mice * Neuronal Plasticity * Oxidative Stress * Random Allocation * Receptors, N-Methyl-D-Aspartate * Testosterone |keywords=* Alzheimer’s disease * N-methyl-D-aspartate receptor-1 * Senescence accelerated mouse * Testosterone * oxidative stress |full-text-url=https://sci-hub.do/10.1080/15287394.2019.1683988 }} {{medline-entry |title=Restored presynaptic synaptophysin and cholinergic inputs contribute to the protective effects of physical running on spatial memory in aged mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31470103 |mesh-terms=* Aging * Animals * Cholinergic Neurons * Hippocampus * Mice * Mice, Inbred C57BL * Physical Conditioning, Animal * Presynaptic Terminals * Spatial Memory * Synaptophysin |keywords=* Aging * Cholinergic cells * Hippocampus * Memory * Physical training * Presynaptic terminals * Synaptophysin |full-text-url=https://sci-hub.do/10.1016/j.nbd.2019.104586 }} {{medline-entry |title=Senescent neurophysiology: Ca signaling from the membrane to the nucleus. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31394200 |mesh-terms=* Aging * Animals * CA1 Region, Hippocampal * Calcium Signaling * Cell Nucleus * Epigenesis, Genetic * Excitatory Postsynaptic Potentials * Humans * Membrane Potentials * Neuronal Plasticity * Pyramidal Cells * Receptors, N-Methyl-D-Aspartate |keywords=* Afterhyperpolarization * Aging * Epigenetics * Hippocampus * N-methyl-D-aspartate receptor * Synaptic plasticity * Transcription |full-text-url=https://sci-hub.do/10.1016/j.nlm.2019.107064 }} ==CA2== {{medline-entry |title=Maintaining Aging Hippocampal Function with Safe and Feasible Shaking Exercise in SAMP10 Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32526748 |keywords=* Aging * Behavior analysis * Hippocampus * Shaking exercise * Spatial cognition |full-text-url=https://sci-hub.do/10.1159/000507884 }} {{medline-entry |title=One-year Follow-up Study of Hippocampal Subfield Atrophy in Alzheimer's Disease and Normal Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32008518 |mesh-terms=* Aged * Aged, 80 and over * Aging * Alzheimer Disease * Atrophy * Case-Control Studies * Cognitive Dysfunction * Disease Progression * Female * Follow-Up Studies * Hippocampus * Humans * Magnetic Resonance Imaging * Male * Neuroimaging |keywords=* Alzheimer's disease * biomarker * hippocampal * mild cognitive impairment * neurodegenerative diseases * normal aging * radial distance * subfield atrophy |full-text-url=https://sci-hub.do/10.2174/1573405615666190327102052 }} {{medline-entry |title=Maturation of PNN and ErbB4 Signaling in Area [[CA2]] during Adolescence Underlies the Emergence of PV Interneuron Plasticity and Social Memory. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31665627 |mesh-terms=* Aging * Animals * Animals, Newborn * CA2 Region, Hippocampal * Interneurons * Long-Term Synaptic Depression * Male * Memory * Mice * Mice, Inbred C57BL * Neural Inhibition * Neuregulin-1 * Neuronal Plasticity * Parvalbumins * Receptor, ErbB-4 * Receptors, Opioid, delta * Signal Transduction * Social Behavior * Synapses * gamma-Aminobutyric Acid |keywords=* ErbB4 * adolescence * area CA2 * delta opioid receptors * hippocampus * long-term depression * neuregulin 1 * parvalbumin interneuron * perineuronal net * social memory |full-text-url=https://sci-hub.do/10.1016/j.celrep.2019.09.044 }} ==CA3== {{medline-entry |title=Features of Postnatal Hippocampal Development in a Rat Model of Sporadic Alzheimer's Disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32581685 |keywords=* Alzheimer’s disease * OXYS rats * aging * hippocampal mossy fibers * hippocampus * neurogenesis * postnatal development |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289999 }} {{medline-entry |title=Age-Related Changes in Synaptic Plasticity Associated with Mossy Fiber Terminal Integration during Adult Neurogenesis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32332082 |keywords=* aging * conditional transgenic * giant synapse * stratum lucidum * synaptogenesis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240290 }} {{medline-entry |title=Metabotropic Glutamate Receptors at the Aged Mossy Fiber - [[CA3]] Synapse of the Hippocampus. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31917351 |keywords=* aging * hippocampal area CA3 * mGluRs * mossy fibers * synaptic transmission |full-text-url=https://sci-hub.do/10.1016/j.neuroscience.2019.12.016 }} ==CACNA1S== {{medline-entry |title=Increased calcium channel in the lamina propria of aging rat. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31682233 |mesh-terms=* Aging * Animals * Calcium Channel Blockers * Calcium Channels * Cell Line * Fibroblasts * Gene Expression Regulation * Humans * Larynx * Male * Mucous Membrane * Rats * Rats, Sprague-Dawley * Verapamil |keywords=* aging * calcium channel * extracellular matrix * vocal fold |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834399 }} ==CAD== {{medline-entry |title=Serum soluble Klotho is inversely related to coronary artery calcification assessed by intravascular ultrasound in patients with stable coronary artery disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33303310 |keywords=* Aging * Coronary artery calcification * Intravascular ultrasound * Klotho |full-text-url=https://sci-hub.do/10.1016/j.jjcc.2020.11.014 }} {{medline-entry |title=Shear bond strengths of aged and non-aged [[CAD]]/CAM materials after different surface treatments. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33149848 |keywords=* Bond strength * Computer-aided design and computer-aided manufacturing (CAD/CAM) * Laser * Repair * Surface treatment * Thermal aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604239 }} {{medline-entry |title=Prediction of Early Postoperative Major Cardiac Events and In-Hospital Mortality in Elderly Hip Fracture Patients: The Role of Different Types of Preoperative Cardiac Abnormalities on Echocardiography Report. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32546993 |mesh-terms=* Aged * Aortic Valve Stenosis * Cardiovascular Diseases * Comorbidity * Echocardiography * Female * Fracture Fixation * Hip Fractures * Hospital Mortality * Humans * Male * Postoperative Complications * Prognosis * Risk Factors |keywords=* aging * echocardiographic abnormality * hip fracture surgery * mortality * postoperative cardiac complications |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266334 }} {{medline-entry |title=[Polymorbidity in elderly patients needing myocardial revascularization (a review article).] |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31800187 |mesh-terms=* Aged * Cognitive Dysfunction * Coronary Artery Disease * Humans * Myocardial Revascularization * Quality of Life * Risk |keywords=* aging * elderly * ischemic heart disease * myocardial revascularization * polymorbidity }} {{medline-entry |title=Fracture force of [[CAD]]/CAM resin composite crowns after in vitro aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31712983 |mesh-terms=* Ceramics * Composite Resins * Computer-Aided Design * Crowns * Dental Porcelain * Dental Restoration Failure * Dental Stress Analysis * Humans * Materials Testing |keywords=* Aging * CAD/CAM * CAD/CAM bloc * Dental material * Fit * Preparation * Resin composite * Resin-based material * Storage * TCML |full-text-url=https://sci-hub.do/10.1007/s00784-019-03099-1 }} {{medline-entry |title=Clinical performance of chairside monolithic lithium disilicate glass-ceramic [[CAD]]-CAM crowns. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31565848 |mesh-terms=* Ceramics * Computer-Aided Design * Crowns * Dental Porcelain * Dental Prosthesis Design * Humans * Materials Testing |keywords=* CAD-CAM * chairside * dental crowns * lithium disilicate * longevity * survival |full-text-url=https://sci-hub.do/10.1111/jerd.12531 }} {{medline-entry |title=Acute resveratrol supplementation in coronary artery disease: towards patient stratification. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31429599 |mesh-terms=* Aged * Biomarkers * Brachial Artery * Cardiac Rehabilitation * Coronary Artery Bypass * Coronary Artery Disease * Cross-Over Studies * Exercise Therapy * Female * Humans * Kinetics * Male * Middle Aged * Oxygen * Oxygen Consumption * Percutaneous Coronary Intervention * Resveratrol * Single-Blind Method * Treatment Outcome * Vasodilation |keywords=* Antioxidant * aging * endothelial dysfunction * oxygen uptake |full-text-url=https://sci-hub.do/10.1080/14017431.2019.1657584 }} ==CARM1== {{medline-entry |title=[[CARM1]] regulates senescence during airway epithelial cell injury in COPD pathogenesis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31461302 |mesh-terms=* Aged * Animals * Apoptosis * Cell Differentiation * Cell Proliferation * Cellular Senescence * Epithelial Cells * Female * Humans * Male * Mice, Inbred C57BL * Mice, Knockout * Middle Aged * Naphthalenes * Protein-Arginine N-Methyltransferases * Pulmonary Disease, Chronic Obstructive * Respiratory Mucosa * Wound Healing |keywords=* CARM1 * COPD * airway epithelium * senescence |full-text-url=https://sci-hub.do/10.1152/ajplung.00441.2018 }} ==CASP3== {{medline-entry |title=Does cartilage ERα overexpression correlate with osteoarthritic chondrosenescence? Indications from [i]Labisia pumila[/i] OA mitigation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31502578 |mesh-terms=* Aging * Animals * Bone Development * Cartilage * Chondrocytes * Diclofenac * Disease Models, Animal * Estrogen Receptor alpha * Flavonoids * Gallic Acid * Gene Expression Regulation * Humans * Iodoacetates * Matrix Metalloproteinase 13 * Metabolism * Osteoarthritis * Ovariectomy * Plant Extracts * Primulaceae * Rats }} ==CAT== {{medline-entry |title=Training improves the handling of inhaler devices and reduces the severity of symptoms in geriatric patients suffering from chronic-obstructive pulmonary disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33036566 |keywords=* Chronic-obstructive pulmonary disease - Inhaler devices * Compliance * Geriatrics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547456 }} {{medline-entry |title=7-chloro-4-(phenylselanyl) quinoline co-treatment prevent oxidative stress in diabetic-like phenotype induced by hyperglycidic diet in Drosophila melanogaster. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32931926 |keywords=* 4-PSQ * 7-chloro-4-(phenylselanyl) quinolone * Antioxidant effect * Diabetic-like phenotype * Hyperglycidic diet * Longevity * Oxidative stress |full-text-url=https://sci-hub.do/10.1016/j.cbpc.2020.108892 }} {{medline-entry |title=Aging influences in the blood-brain barrier permeability and cerebral oxidative stress in sepsis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32827711 |keywords=* Aging * Blood-brain barrier * Brain * Oxidative stress * Sepsis |full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111063 }} {{medline-entry |title=2 -Deoxy - d-glucose at chronic low dose acts as a caloric restriction mimetic through a mitohormetic induction of ROS in the brain of accelerated senescence model of rat. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32559563 |keywords=* 2-Deoxy- d-glucose * Aging * Brain * CRM * Mitohormosis * ROS |full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104133 }} {{medline-entry |title=Ceftriaxone improves senile neurocognition damages induced by D-galactose in mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32440324 |keywords=* Aging * Ceftriaxone * D-galactose * Mice * Oxidative stress |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229512 }} {{medline-entry |title=Ginsenoside Rg1 protects against d-galactose induced fatty liver disease in a mouse model via FOXO1 transcriptional factor. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32437790 |mesh-terms=* Animals * Antioxidants * Cellular Senescence * Disease Models, Animal * Fatty Liver * Forkhead Box Protein O1 * Galactose * Ginsenosides * Lipid Peroxidation * Male * Medicine, Chinese Traditional * Mice * Mice, Inbred C57BL * Oxidative Stress * Protective Agents * Transcription Factors |keywords=* D-galactose * FOXO1 * Non-alcoholic fatty liver disease * Rg1 * Senescence |full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.117776 }} {{medline-entry |title=Effects of long-term intermittent versus chronic calorie restriction on oxidative stress in a mouse cancer model. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31424629 |mesh-terms=* Aging * Animals * Antioxidants * Caloric Restriction * Catalase * Erythrocytes * Female * Glutathione * Lipid Peroxidation * Malondialdehyde * Mammary Neoplasms, Experimental * Mice, Inbred C57BL * Oxidative Stress * Superoxide Dismutase |keywords=* MMTV-TGF-α mice * breast cancer * energy restriction * intermittent calorie restriction * mammary tumor * oxidative stress |full-text-url=https://sci-hub.do/10.1002/iub.2145 }} {{medline-entry |title=The Toxicity of Nonaged and Aged Coated Silver Nanoparticles to Freshwater Alga Raphidocelis subcapitata. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31403715 |mesh-terms=* Aquatic Organisms * Chlorophyta * Fresh Water * Hydrodynamics * Lipid Peroxidation * Metal Nanoparticles * Particle Size * Reactive Oxygen Species * Silver * Static Electricity * Toxicity Tests |keywords=* Aquatic toxicology * Ecotoxicology * Environmental fate * Heavy metals * Nanoparticle aging * Nanotoxicology |full-text-url=https://sci-hub.do/10.1002/etc.4549 }} ==CBS== {{medline-entry |title=Permanent cystathionine-β-Synthase gene knockdown promotes inflammation and oxidative stress in immortalized human adipose-derived mesenchymal stem cells, enhancing their adipogenic capacity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32800520 |keywords=* Cellular senescence * Cystathionine β-synthase * Human adipose-derived mesenchymal stem cells * Inflammation * Oxidative stress and adipogenesis |full-text-url=https://sci-hub.do/10.1016/j.redox.2020.101668 }} {{medline-entry |title=Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32027885 |mesh-terms=* Animals * Antioxidants * Cardiovascular System * Cystathionine beta-Synthase * Cystathionine gamma-Lyase * Gene Expression Regulation, Enzymologic * Hydrogen Sulfide * Male * Mice, Inbred C57BL * Mice, Knockout * Myocardial Reperfusion Injury * Myocytes, Cardiac * Nitric Oxide * Phenotype * Reactive Oxygen Species * Sulfurtransferases * Vasodilation |keywords=* 3-mercaptopyruvate transferase (3-MST) * Aging * Blood pressure * Myocardial infarction * Nitric Oxide (NO) * Reactive Oxygen Species (ROS) |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7657663 }} ==CBX3== {{medline-entry |title=Biological functions of chromobox (CBX) proteins in stem cell self-renewal, lineage-commitment, cancer and development. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32979540 |keywords=* Aging * Bone * CBX1 * CBX2 * CBX3 * CBX4 * CBX5 * CBX6 * CBX7 * CBX8 * Cancer * Chromatin * Development * Epigenetics * H3K27me3 * H3K9me3 * Lineage-commitment * Osteoblast * Senescence * Stem cell |full-text-url=https://sci-hub.do/10.1016/j.bone.2020.115659 }} ==CCK== {{medline-entry |title=Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33242601 |keywords=* Intervertebral disc degeneration * NF-κB pathway * Nrf2 * Quercetin * Senescence |full-text-url=https://sci-hub.do/10.1016/j.joca.2020.11.006 }} {{medline-entry |title=Astragalus improve aging bone marrow mesenchymal stem cells (BMSCs) vitality and osteogenesis through VD-FGF23-Klotho axis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32355520 |keywords=* Astragalus * BMSCs * VD-FGF23-Klotho axis * aging * osteogenesis differentiation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191145 }} {{medline-entry |title=Effects of Age on Acute Appetite-Related Responses to Whey-Protein Drinks, Including Energy Intake, Gastric Emptying, Blood Glucose, and Plasma Gut Hormone Concentrations-A Randomized Controlled Trial. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32268554 |keywords=* aging * appetite * energy intake * gastric emptying * glucose * gut hormones * whey protein |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231005 }} {{medline-entry |title=Lactose induced redox-dependent senescence and activated Nrf2 pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31934025 |keywords=* Lactose * Nrf2 * ROS * cellular senescence * oxidative stress |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949649 }} {{medline-entry |title=Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31816893 |mesh-terms=* Adenine * Animals * Atherosclerosis * Autophagy * Cell Survival * Cellular Senescence * Cyclin-Dependent Kinase Inhibitor p16 * Cyclin-Dependent Kinase Inhibitor p21 * Disease Progression * Foam Cells * Hepatocyte Growth Factor * Lipid Metabolism * Lipoproteins, LDL * Mice * Proto-Oncogene Proteins * Quercetin * RAW 264.7 Cells * Sirolimus * Up-Regulation |keywords=* RAW264.7 * atherosclerosis * autophagy * quercetin * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928812 }} {{medline-entry |title=LncRNA AW112010 Promotes Mitochondrial Biogenesis and Hair Cell Survival: Implications for Age-Related Hearing Loss. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31781342 |mesh-terms=* Adenosine Triphosphate * Aging * Animals * Cell Survival * DNA-Binding Proteins * Gene Silencing * Hair Cells, Auditory * Hearing Loss * Mice * Mitochondria * Organelle Biogenesis * RNA, Long Noncoding * Resveratrol * Signal Transduction * Transcription Factors |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855056 }} {{medline-entry |title=Effects of age on feeding response: Focus on the rostral C1 neuron and its glucoregulatory proteins. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31705967 |keywords=* Aging * Catecholaminergic neurons * Feeding response * Glucoprivation * Rostral ventrolateral medulla |full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110779 }} {{medline-entry |title=Ser-Tyr and Asn-Ala, vasorelaxing dipeptides found by comprehensive screening, reduce blood pressure via different age-dependent mechanisms. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31685714 |mesh-terms=* Aging * Amino Acid Sequence * Animals * Antihypertensive Agents * Blood Pressure * Cholecystokinin * Dipeptides * Drug Evaluation, Preclinical * Hypertension * Male * Mesenteric Arteries * Nitric Oxide * Peptide Library * Proglumide * Rats * Rats, Inbred SHR * Receptors, Cholecystokinin * Vasodilation * Vasodilator Agents |keywords=* aging * dipeptide library * nitric oxide * structure-activity relationship * vasorelaxation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874431 }} {{medline-entry |title=Fisetin, via CKIP-1/REGγ, limits oxidized LDL-induced lipid accumulation and senescence in RAW264.7 macrophage-derived foam cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31655030 |mesh-terms=* Animals * Autoantigens * Carrier Proteins * Cellular Senescence * Flavonoids * Foam Cells * Lipid Metabolism * Lipoproteins, LDL * Mice * Proteasome Endopeptidase Complex * RAW 264.7 Cells * Signal Transduction |keywords=* CKIP-1/REGγ signaling * Fisetin * Lipid accumulation * RAW264.7 * Senescence |full-text-url=https://sci-hub.do/10.1016/j.ejphar.2019.172748 }} ==CCL11== {{medline-entry |title=CCL-11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-Psychiatric Disorders. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32887304 |keywords=* Alzheimer’s disease * CCL-11 * aging * behaviour * biomarkers * brain * cytokines * eotaxin * prevention * schizophrenia * stroke |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558796 }} ==CCL17== {{medline-entry |title=Aging and chronic high-fat feeding negatively affects kidney size, function, and gene expression in CTRP1-deficient mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33085906 |keywords=* aging * heart * kidney * metabolism * obesity |full-text-url=https://sci-hub.do/10.1152/ajpregu.00139.2020 }} ==CCL19== {{medline-entry |title=Age-Related Gliosis Promotes Central Nervous System Lymphoma through [[CCL19]]-Mediated Tumor Cell Retention. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31526758 |mesh-terms=* Adolescent * Adult * Aged * Aging * Animals * Astrocytes * Blood-Brain Barrier * Cell Line, Tumor * Central Nervous System Neoplasms * Chemokine CCL19 * Chemokine CXCL12 * Disease Models, Animal * Female * Gliosis * Humans * Intravital Microscopy * Lymphoma * Male * Mice * Mice, Transgenic * Microscopy, Fluorescence, Multiphoton * Middle Aged * NF-kappa B * Receptors, CCR7 * Time-Lapse Imaging * Young Adult |keywords=* CCL19 * CNSL * CXCL12 * DLBCL * PCNSL * SCNSL * gliosis * lymphoma * metastasis * neuroinflammation |full-text-url=https://sci-hub.do/10.1016/j.ccell.2019.08.001 }} ==CCL2== {{medline-entry |title=β1 Integrin regulates adult lung alveolar epithelial cell inflammation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31873073 |mesh-terms=* Aging * Alveolar Epithelial Cells * Animals * Cell Adhesion * Chemokine CCL2 * Chemokines * Disease Models, Animal * Epithelium * Integrin beta1 * Lung * Macrophages * Mice * Mice, Inbred C57BL * Mice, Knockout * Pneumonia * Pulmonary Disease, Chronic Obstructive * Receptors, CCR2 |keywords=* COPD * Inflammation * Integrins * Macrophages * Pulmonology |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098727 }} ==CCL20== {{medline-entry |title=p53 and p53-related mediators PAI-1 and IGFBP-3 are downregulated in peripheral blood mononuclear cells of HIV-patients exposed to non-nucleoside reverse transcriptase inhibitors. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32272174 |keywords=* Aging * Antiretroviral drugs * HIV * Inflammation * NNRTI * Senescence * p53 |full-text-url=https://sci-hub.do/10.1016/j.antiviral.2020.104784 }} ==CCL28== {{medline-entry |title=Age-related chemokine alterations affect IgA secretion and gut immunity in female mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32277312 |keywords=* Aging * CCL25 * CCL28 * Gut immunity * IgA |full-text-url=https://sci-hub.do/10.1007/s10522-020-09877-9 }} ==CCN1== {{medline-entry |title=Sodium tanshinone IIA sulfonate restrains fibrogenesis through induction of senescence in mice with induced deep endometriosis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32651107 |keywords=* Deep endometriosis * Fibrogenesis * Mouse * Senescence * Sodium tanshinone IIA sulfonate |full-text-url=https://sci-hub.do/10.1016/j.rbmo.2020.04.006 }} {{medline-entry |title=Inhibition of cellular communication network factor 1 ([[CCN1]])-driven senescence slows down cartilage inflammaging and osteoarthritis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32622876 |keywords=* CCN1 * Cartilage inflammaging * Chondrocyte cluster * Osteoarthritis * Senescence |full-text-url=https://sci-hub.do/10.1016/j.bone.2020.115522 }} {{medline-entry |title=The senescence-associated matricellular protein [[CCN1]] in plasma of human subjects with idiopathic pulmonary fibrosis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31765873 |mesh-terms=* Aged * Cellular Senescence * Cysteine-Rich Protein 61 * Disease Progression * Enzyme-Linked Immunosorbent Assay * Female * Humans * Idiopathic Pulmonary Fibrosis * Male * Middle Aged * Outcome Assessment, Health Care * Predictive Value of Tests * Survival Rate |keywords=* CCN1 * Cellular senescence * Idiopathic pulmonary fibrosis * Transplant-free survival |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023981 }} ==CCN3== {{medline-entry |title=[[CCN3]] Signaling Is Differently Regulated in Placental Diseases Preeclampsia and Abnormally Invasive Placenta. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33304321 |keywords=* CCN3 * abnormally invasive placenta * invasion * preeclampsia * senescence * trophoblast |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701218 }} {{medline-entry |title=[[CCN3]] (NOV) Drives Degradative Changes in Aging Articular Cartilage. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33066270 |keywords=* CCN3 * NOV * SASP * aging * cellular communication network factor 3 * oxidative stress * p21 * p53 * primary chondrocytes * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593953 }} ==CCND1== {{medline-entry |title=Effects of hydrogen peroxide, doxorubicin and ultraviolet irradiation on senescence of human dental pulp stem cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32592933 |mesh-terms=* Cells, Cultured * Cellular Senescence * Dental Pulp * Doxorubicin * Humans * Hydrogen Peroxide * Stem Cells * Ultraviolet Rays |keywords=* Cell cycle * ROS * Stress induced senescence * Ultraviolet irradiation * p21 |full-text-url=https://sci-hub.do/10.1016/j.archoralbio.2020.104819 }} ==CCND3== {{medline-entry |title=The effect of aging on the biological and immunological characteristics of periodontal ligament stem cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32727592 |keywords=* Aging * Immunosuppression * Osteogenic differentiation * Periodontal ligament stem cells * Peripheral blood mononuclear cells * Tissue engineering |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392710 }} ==CCR2== {{medline-entry |title=Hip Fracture Leads to Transitory Immune Imprint in Older Patients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33072114 |keywords=* acute stress * aging * immune response * inflammation * regulation loop |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7533556 }} {{medline-entry |title=The CC-chemokine receptor 2 is involved in the control of ovarian folliculogenesis and fertility lifespan in mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32615332 |keywords=* Aging * CCR2 * Fertility * Follicle * Ovary |full-text-url=https://sci-hub.do/10.1016/j.jri.2020.103174 }} {{medline-entry |title=Deficit of resolution receptor magnifies inflammatory leukocyte directed cardiorenal and endothelial dysfunction with signs of cardiomyopathy of obesity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32543720 |keywords=* inflammatory macrophage * kidney function * non-resolving inflammation * obesogenic aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704037 }} {{medline-entry |title=Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32154790 |keywords=* Aging * Bone marrow transplantation * Cardiology * Hematopoietic stem cells * Macrophages |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213793 }} {{medline-entry |title=Inflammation and Ectopic Fat Deposition in the Aging Murine Liver Is Influenced by [[CCR2]]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31843499 |mesh-terms=* Aging * Animals * Body Weight * Chemokine CCL2 * Disease Models, Animal * Female * Gene Expression Profiling * Inflammation * Macrophages * Male * Mice * Mice, Inbred C57BL * Non-alcoholic Fatty Liver Disease * Organ Size * Receptors, CCR2 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013280 }} {{medline-entry |title=Klotho-mediated targeting of CCL2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31545552 |mesh-terms=* Aged * Cell Line, Tumor * Cell Movement * Cell Proliferation * Cellular Microenvironment * Cellular Senescence * Chemokine CCL2 * Colorectal Neoplasms * Disease Progression * Down-Regulation * Doxorubicin * Female * Glucuronidase * Human Umbilical Vein Endothelial Cells * Humans * Male * Middle Aged * NF-kappa B * Neoplasm Invasiveness * Proportional Hazards Models * Signal Transduction * Stromal Cells |keywords=* CCL2 * Klotho * colorectal cancer * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822285 }} ==CCR3== {{medline-entry |title=Low Molecular Weight Hyaluronan Induces an Inflammatory Response in Ovarian Stromal Cells and Impairs Gamete Development In Vitro. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32033185 |mesh-terms=* Aging * Animals * Extracellular Matrix * Female * Germ Cells * Granulosa Cells * Hyaluronan Receptors * Hyaluronic Acid * Inflammation * Mice * Mice, Inbred BALB C * Mice, Inbred C57BL * Molecular Weight * Ovary * Stromal Cells |keywords=* hyaluronan fragments * inflammation * ovarian biology * reproductive aging * stroma |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036885 }} ==CCR5== {{medline-entry |title=[Enhancement can do harm]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31532388 |mesh-terms=* Adult * Aged * CRISPR-Cas Systems * China * Embryo Research * Gene Editing * Gene Silencing * Genetic Enhancement * Genome-Wide Association Study * HIV Infections * HIV-1 * Humans * Longevity * Middle Aged * Receptors, CCR5 |full-text-url=https://sci-hub.do/10.1051/medsci/2019136 }} ==CCS== {{medline-entry |title=Frailty Significantly Associated with a Risk for Mid-term Outcomes in Elderly Chronic Coronary Syndrome Patients: a Prospective Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33306315 |keywords=* Aging * Canada * Confidence Intervals * Death * Frail Elderly * Frailty * Heart * Multivariate Analysis * Prognosis * Risk Factors |full-text-url=https://sci-hub.do/10.21470/1678-9741-2019-0484 }} {{medline-entry |title=Microbleeds and Medial Temporal Atrophy Determine Cognitive Trajectories in Normal Aging: A Longitudinal PET-MRI Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32925053 |keywords=* Atrophy * cognition * imaging markers * medial temporal lobe * microbleeds * normal aging |full-text-url=https://sci-hub.do/10.3233/JAD-200559 }} {{medline-entry |title=Hippocampal Volume Loss, Brain Amyloid Accumulation, and APOE Status in Cognitively Intact Elderly Subjects. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31846965 |mesh-terms=* Aged * Aged, 80 and over * Amyloid beta-Peptides * Apolipoprotein E4 * Brain * Cognitive Aging * Female * Hippocampus * Humans * Longitudinal Studies * Magnetic Resonance Imaging * Male * Positron-Emission Tomography |keywords=* APOE * Aging * Amyloid * Hippocampus |full-text-url=https://sci-hub.do/10.1159/000504302 }} {{medline-entry |title=Amyloid Load, Hippocampal Volume Loss, and Diffusion Tensor Imaging Changes in Early Phases of Brain Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31803008 |keywords=* APOE genotyping * amyloid deposition * magnetic resonance imaging * normal aging * positron emission tomography |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872975 }} {{medline-entry |title=Lower bone mass is associated with subclinical atherosclerosis, endothelial dysfunction and carotid thickness in the very elderly. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31783200 |keywords=* Aging * Endothelial dysfunction * Osteoporosis * Subclinical atherosclerosis |full-text-url=https://sci-hub.do/10.1016/j.atherosclerosis.2019.11.007 }} ==CD14== {{medline-entry |title=Human innate immune cell crosstalk induces melanoma cell senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32939325 |keywords=* NK cell * cytokines * melanoma * senescence * slanMo |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470184 }} {{medline-entry |title=Fusion Potential of Human Osteoclasts In Vitro Reflects Age, Menopause, and In Vivo Bone Resorption Levels of Their Donors-A Possible Involvement of DC-STAMP. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32887359 |keywords=* CTX * DC-STAMP * DNA methylation * aging * cell fusion * epigenetics * menopause * multinucleation * osteoclast * osteoclastogenesis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504560 }} {{medline-entry |title=Association of [[CD14]] with incident dementia and markers of brain aging and injury. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31818907 |mesh-terms=* Aged * Aged, 80 and over * Aging * Atrophy * Biomarkers * Brain * Cognitive Dysfunction * Dementia * Female * Humans * Incidence * Lipopolysaccharide Receptors * Longitudinal Studies * Male * Middle Aged |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7108812 }} {{medline-entry |title=Compromised Bone Healing in Aged Rats Is Associated With Impaired M2 Macrophage Function. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31681320 |mesh-terms=* Age Factors * Aging * Animals * Antigens, CD * Antigens, Differentiation, Myelomonocytic * Biomarkers * Bone Regeneration * Bone and Bones * Female * Fractures, Bone * Gene Expression * Lipopolysaccharide Receptors * Macrophages * Osteotomy * Rats, Sprague-Dawley * Wound Healing |keywords=* CD14+ cells * aging * angiogenesis * bone regeneration * compromised healing * macrophage * monocyte |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813416 }} ==CD19== {{medline-entry |title=Sequential treatment with aT19 cells generates memory CAR-T cells and prolongs the lifespan of Raji-B-NDG mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31634527 |mesh-terms=* Animals * Antigens, CD19 * Cell Line, Tumor * Combined Modality Therapy * Disease-Free Survival * HEK293 Cells * Healthy Volunteers * Humans * Immunologic Memory * Immunotherapy, Adoptive * Longevity * Lymphoma, B-Cell * Mice * Neoplasm Recurrence, Local * Receptors, Chimeric Antigen * Recombinant Proteins * Remission Induction * T-Lymphocytes * Time Factors * Transduction, Genetic * Transplantation, Autologous * Xenograft Model Antitumor Assays |keywords=* Autologous CD19 T cells * Chimeric antigen receptor * Memory T cells * Sequential therapy |full-text-url=https://sci-hub.do/10.1016/j.canlet.2019.10.022 }} ==CD27== {{medline-entry |title=The Interplay between [[CD27]] and [[CD27]] B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32130900 |keywords=* CD27 * VH repertoire * aging * germinal center * immunodeficiency * immunological memory * memory B cells * pregnancy * spleen * vaccine |full-text-url=https://sci-hub.do/10.1016/j.celrep.2020.02.022 }} {{medline-entry |title=CMV-independent increase in [[CD27]]-CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31993214 |keywords=* Biomarkers * Senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972903 }} {{medline-entry |title=Compartmentalized cytotoxic immune response leads to distinct pathogenic roles of natural killer and senescent CD8 T cells in human cutaneous leishmaniasis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31925782 |mesh-terms=* CD56 Antigen * CD57 Antigens * Case-Control Studies * Cellular Senescence * Cytotoxicity, Immunologic * Female * Gene Expression Regulation * Host-Parasite Interactions * Humans * Interferon-gamma * Killer Cells, Natural * Lectins, C-Type * Leishmania braziliensis * Leishmaniasis, Cutaneous * Male * Oligosaccharides * Receptors, Immunologic * Severity of Illness Index * Sialyl Lewis X Antigen * Signal Transduction * Skin * T-Lymphocytes, Cytotoxic |keywords=* Leishmania braziliensis * CD8+ T cells * cellular senescence * cutaneous leishmaniasis * immunopathology * natural killer cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078002 }} {{medline-entry |title=[[CD27]]- IgD- B cell memory subset associates with inflammation and frailty in elderly individuals but only in males. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31423147 |keywords=* Aging * B cell * Frailty * Immunosenescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693136 }} ==CD28== {{medline-entry |title=Premature CD4 T Cells Senescence Induced by Chronic Infection in Patients with Acute Coronary Syndrome. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33269101 |keywords=* CD28null T cells * CD4+ T cells * acute coronary syndrome * immunosenescence * infection |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673853 }} {{medline-entry |title=The IMMENSE Study: The Interplay Between iMMune and ENdothelial Cells in Mediating Cardiovascular Risk in Systemic Lupus Erythematosus. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33193356 |keywords=* angiogenic T cells * cardiovascular risk * endothelial progenitor cells * immunosenescence * systemic lupus erythematosus |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658008 }} {{medline-entry |title=Emergence of T cell immunosenescence in diabetic chronic kidney disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33088331 |keywords=* BMI * CKD * Diabetes * Immunosenescence * T cell |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574244 }} {{medline-entry |title=The relationship between Chlamydia pneumoniae infection and CD4/CD8 ratio, lymphocyte subsets in middle-aged and elderly individuals. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33068732 |keywords=* CD4/CD8 ratio * Chlamydia pneumoniae * Immune profile * Immunosenescence * Lymphocyte subsets |full-text-url=https://sci-hub.do/10.1016/j.micpath.2020.104541 }} {{medline-entry |title=Next steps in mechanisms of inflammaging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32960694 |keywords=* Aging * autophagy * glutathione * membrane potential * mitochondria * oxidative stress |full-text-url=https://sci-hub.do/10.1080/15548627.2020.1822089 }} {{medline-entry |title=A randomized pilot trial to evaluate the benefit of the concomitant use of atorvastatin and Raltegravir on immunological markers in protease-inhibitor-treated subjects living with HIV. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32941476 |mesh-terms=* Adult * Anti-HIV Agents * Anticholesteremic Agents * Atorvastatin * CD4-Positive T-Lymphocytes * CD8-Positive T-Lymphocytes * Female * HIV Infections * HIV Protease Inhibitors * Humans * Immunosenescence * Inflammation * Lymphocyte Activation * Male * Middle Aged * Pilot Projects * Raltegravir Potassium |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498036 }} {{medline-entry |title=Aging affects responsiveness of peripheral blood mononuclear cells to immunosuppression of periodontal ligament stem cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32663414 |keywords=* Periodontal ligament stem cells * T lymphocytes * age * coculture * cytokines * immunophenotyping * immunosenescence * immunosuppression * peripheral blood mononuclear cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364836 }} {{medline-entry |title=Comparison of Donepezil, Memantine, Melatonin, and Liuwei Dihuang Decoction on Behavioral and Immune Endocrine Responses of Aged Senescence-Accelerated Mouse Resistant 1 Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32477103 |keywords=* Liuwei Dihuang decoction * aging * cognition * immune response * inflammation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241684 }} {{medline-entry |title=Immunosenescent characteristics of T cells in young patients following haploidentical haematopoietic stem cell transplantation from parental donors. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32280463 |keywords=* CD28− T cells * HaploSCT * immune monitoring * immunosenescence * telomere length |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7142179 }} {{medline-entry |title=Diagnosis-independent loss of T-cell costimulatory molecules in individuals with cytomegalovirus infection. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32209361 |keywords=* Biological aging * Cytomegalovirus * Depression * Immunosenescence * Major depressive disorder * Sex differences * T-cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594105 }} {{medline-entry |title=Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32190092 |keywords=* Ageing * Cell senescence * Cognitive impairment * Immune ageing * Rheumatoid arthritis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068869 }} {{medline-entry |title=Accelerated immune aging was correlated with lupus-associated brain fog in reproductive-age systemic lupus erythematosus patients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32107852 |keywords=* immunosenescence * lupus-associated brain fog * systemic lupus erythematosus |full-text-url=https://sci-hub.do/10.1111/1756-185X.13816 }} {{medline-entry |title=T cells, aging and senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32092501 |keywords=* Aging * Senescence * T cells |full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110887 }} {{medline-entry |title=Liver fibrosis and accelerated immune dysfunction (immunosenescence) among HIV-infected Russians with heavy alcohol consumption - an observational cross-sectional study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31892306 |mesh-terms=* Adult * Alcoholism * CD28 Antigens * CD4-Positive T-Lymphocytes * CD57 Antigens * CD8-Positive T-Lymphocytes * Cross-Sectional Studies * Female * HIV Infections * Hepatitis C * Humans * Immunologic Memory * Immunosenescence * Leukocyte Common Antigens * Linear Models * Liver Cirrhosis, Alcoholic * Male * Phenotype * Randomized Controlled Trials as Topic * Russia * Zinc |keywords=* Alcohol * HIV * Immune senescence * Liver fibrosis * Russia |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938606 }} {{medline-entry |title=Effect of Allogenic Bone Marrow Mesenchymal Stem Cell Transplantation on T Cells of Old Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31895587 |keywords=* aging * cellular senescence * memory T cells * stem cell |full-text-url=https://sci-hub.do/10.1089/cell.2019.0055 }} {{medline-entry |title=Peripheral antibody concentrations are associated with highly differentiated T cells and inflammatory processes in the human bone marrow. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31462901 |keywords=* Aging * Antibodies * B cells * Bone marrow * Exhaustion * Immunosenescence * Inflammation * Pro-inflammatory * Senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706884 }} ==CD33== {{medline-entry |title=Maximum reproductive lifespan correlates with [[CD33]]rSIGLEC gene number: Implications for NADPH oxidase-derived reactive oxygen species in aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31907986 |mesh-terms=* Animals * Gene Dosage * Humans * Longevity * NADPH Oxidases * Neutrophils * Reactive Oxygen Species * Sialic Acid Binding Ig-like Lectin 3 * Whale, Killer |keywords=* CD33rSIGLEC * NADPH-oxidase * prolonged post-reproductive lifespan * reactive oxygen species |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018541 }} ==CD34== {{medline-entry |title=Comparing the Effect of TGF-β Receptor Inhibition on Human Perivascular Mesenchymal Stromal Cells Derived from Endometrium, Bone Marrow and Adipose Tissues. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33271899 |keywords=* SUSD2 * adipose tissue * apoptosis * bone marrow * clonogenicity * endometrium * menstrual fluid * perivascular mesenchymal stromal cells * placenta * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712261 }} {{medline-entry |title=ACE2/ACE imbalance and impaired vasoreparative functions of stem/progenitor cells in aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33247425 |keywords=* ACE2 * Aging * Angiotensin-(1-7) * Hematopoietic stem/progenitor cells * Ischemia |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694587 }} {{medline-entry |title=Innovative Mind-Body Intervention Day Easy Exercise Increases Peripheral Blood [[CD34]] Cells in Adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32841054 |keywords=* CD34+ cells * aging * day easy exercise * mind–body intervention |full-text-url=https://sci-hub.do/10.1177/0963689720952352 }} {{medline-entry |title=Human Thymic Involution and Aging in Humanized Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32733465 |keywords=* aging * human * humanized mouse * recent thymic emigrants * thymus involution |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358581 }} {{medline-entry |title=Coinhibition of activated p38 MAPKα and mTORC1 potentiates stemness maintenance of HSCs from SR1-expanded human cord blood [[CD34]] cells via inhibition of senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32602209 |keywords=* HSC stemness maintenance * Stem Regenin 1 * cellular senescence * ex vivo expansion * human cord blood CD34+ cells * mammalian target of rapamycin complex 1 * p38 mitogen-activated protein kinase α |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695631 }} {{medline-entry |title=Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32531351 |mesh-terms=* Age Factors * Aged * Aged, 80 and over * Aging * Choroid * Endothelial Cells * Female * Gene Expression Regulation * Humans * Infant * Infant, Newborn * Inflammation * Inflammation Mediators * Macular Degeneration * Male * Middle Aged * Phenotype * Sequence Analysis, RNA * Single-Cell Analysis |keywords=* Age-related macular degeneration * Choriocapillaris * Choroid * Infant * Pericytes * Single-cell |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396301 }} {{medline-entry |title=Mesenchymal stem cells repair bone marrow damage of aging rats and regulate autophagy and aging genes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32432372 |keywords=* aging * autophagy * bone marrow injury * mesenchymal stem cells * repair |full-text-url=https://sci-hub.do/10.1002/cbf.3548 }} {{medline-entry |title=Immune cell extracellular vesicles and their mitochondrial content decline with ageing. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31911808 |keywords=* Ageing * Apoptotic bodies * Exosomes * Extracellular vesicles * Immune cells * Immunosenescence * Inflammageing * Microvesicles * Mitochondria |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942666 }} {{medline-entry |title=Young and elderly oral squamous cell carcinoma patients present similar angiogenic profile and predominance of M2 macrophages: Comparative immunohistochemical study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31497915 |mesh-terms=* Adult * Aged * Aged, 80 and over * Antigens, CD * Antigens, Differentiation, Myelomonocytic * Carcinoma, Squamous Cell * Female * Humans * Immunohistochemistry * Immunosenescence * Macrophages * Male * Middle Aged * Mouth Neoplasms * Neovascularization, Pathologic * Receptors, Cell Surface * Tumor Microenvironment |keywords=* M1 and M2 macrophages * angiogenesis * immunohistochemistry * immunosenescence * oral squamous cell carcinoma |full-text-url=https://sci-hub.do/10.1002/hed.25954 }} ==CD36== {{medline-entry |title=Liver osteopontin is required to prevent the progression of age-related nonalcoholic fatty liver disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32638492 |keywords=* Osteopontin * aging * lipid metabolism * nonalcoholic fatty liver disease * p53 * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431823 }} {{medline-entry |title=Reduction of senescence-associated beta-galactosidase activity by vitamin E in human fibroblasts depends on subjects' age and cell passage number. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32479666 |keywords=* CD36 scavenger receptor * alpha-tocopherol * exosomes * extracellular vesicles * gene expression * lysosome * senescence * signal transduction * vitamin E |full-text-url=https://sci-hub.do/10.1002/biof.1636 }} {{medline-entry |title=Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32030468 |keywords=* Aging * Macrophages * Microglia * Oligodendrocyte progenitor cells * Phagocytosis * Remyelination |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181452 }} ==CD38== {{medline-entry |title=Re-equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32935380 |keywords=* CD38 NADase * NAD metabolism * mitochondrial impairment * replicative senescence * telomere biology disorders |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7604620 }} {{medline-entry |title=TNFRSF12A and [[CD38]] Contribute to a Vicious Circle for Chronic Obstructive Pulmonary Disease by Engaging Senescence Pathways. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32537452 |keywords=* aging * chronic inflammation * lung * network analysis * senescence * tissue remodeling |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268922 }} {{medline-entry |title=Aging alters acetylation status in skeletal and cardiac muscles. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32300965 |keywords=* Aging * CD38 * Deacetylation * NAD+ * PARP * SIRT * Skeletal muscle |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286993 }} {{medline-entry |title=[[CD38]] in Neurodegeneration and Neuroinflammation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32085567 |keywords=* ALS. * Alzheimer’s disease * CD38 * NAD * Parkinson’s disease * aging * neurodegeneration * neuroinflammation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072759 }} {{medline-entry |title=[[CD38]], a Receptor with Multifunctional Activities: From Modulatory Functions on Regulatory Cell Subsets and Extracellular Vesicles, to a Target for Therapeutic Strategies. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31783629 |mesh-terms=* ADP-ribosyl Cyclase 1 * Aging * Animals * Antibodies, Monoclonal * B-Lymphocytes, Regulatory * Cell Line * Extracellular Vesicles * Humans * Infections * Membrane Glycoproteins * Mice * Neoplasms * T-Lymphocytes, Regulatory |keywords=* CD38 * adenosine * immune-modulation * regulatory cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953043 }} {{medline-entry |title=[[CD38]] Deficiency Alleviates D-Galactose-Induced Myocardial Cell Senescence Through NAD /Sirt1 Signaling Pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31551807 |keywords=* CD38 * D-galactose * NAD+ * heart senescence * oxidative stress |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735286 }} ==CD4== {{medline-entry |title=Identification of Key Genes and Potential New Biomarkers for Ovarian Aging: A Study Based on RNA-Sequencing Data. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33304387 |keywords=* GEO database * bioinformatics * biomarker * immune cell infiltration * ovarian aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701310 }} {{medline-entry |title=Distinct Age-Related Epigenetic Signatures in [[CD4]] and CD8 T Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33262764 |keywords=* T-cell * T-cell homeostasis * aging * chromatin accessibility * epigenetics * ribosomal proteins |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686576 }} {{medline-entry |title=IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A Foxp3 Cells During Mucosal Infection and Is Dysregulated With Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33240286 |keywords=* Candida * Foxp3 * IL-1β * Treg * Treg17 * aging * fungal infection * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677307 }} {{medline-entry |title=Thymus involution sets the clock of declined immunity and repair with aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33248315 |keywords=* Aging * Chronic systemic inflammation * Dysregulated CD4 T cells * Immune-mediated repair * Thymus |full-text-url=https://sci-hub.do/10.1016/j.arr.2020.101231 }} {{medline-entry |title=Food insecurity and T-cell dysregulation in women living with HIV on antiretroviral therapy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33247896 |keywords=* HIV * exhaustion * food insecurity * immune activation * senescence |full-text-url=https://sci-hub.do/10.1093/cid/ciaa1771 }} {{medline-entry |title=Rapamycin Eyedrops Increased [[CD4]] Foxp3 Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33255287 |keywords=* aging * dry eye * goblet cell * inflammation * lacrimal gland * ocular surface * rapamycin |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727717 }} {{medline-entry |title=Antioxidants N-Acetylcysteine and Vitamin C Improve T Cell Commitment to Memory and Long-Term Maintenance of Immunological Memory in Old Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33228213 |keywords=* NAC * T cells * aging * antioxidants * immunosenescence * vaccination * vitamin C |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699597 }} {{medline-entry |title=Evolution of comorbidities in people living with HIV between 2004 and 2014: cross-sectional analyses from ANRS CO3 Aquitaine cohort. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33198667 |keywords=* Aging * Cardiovascular events * Chronic kidney disease * Comorbidities * HIV |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670698 }} {{medline-entry |title=Impact of age on [[CD4]] recovery and viral suppression over time among adults living with HIV who initiated antiretroviral therapy in the African Cohort Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33183355 |keywords=* Elders on antiretroviral drugs * HIV and aging * HIV treatment outcomes * Sub-saharan Africa |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664082 }} {{medline-entry |title=hPMSCs protects against D-galactose-induced oxidative damage of [[CD4]] T cells through activating Akt-mediated Nrf2 antioxidant signaling. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33148324 |keywords=* Aging * CD4+ T cells * Nrf2 * Oxidative stress * Senescence-associated secretoryphenotype * hPMSC |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641865 }} {{medline-entry |title=Substantial gap in primary care: older adults with HIV presenting late to care. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33129258 |keywords=* Aging population * HIV * Older adults * Risk * Stigma * Testing |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603686 }} {{medline-entry |title=Quantitative Digitography Measures Fine Motor Disturbances in Chronically Treated HIV Similar to Parkinson's Disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33132893 |keywords=* HIV—human immunodeficiency virus * Parkinson’s disease * aging * fine motor activities * motor control |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575770 }} {{medline-entry |title=Monocyte and T Cell Immune Phenotypic Profiles Associated With Age Advancement Differ Between People With HIV, Lifestyle-Comparable Controls and Blood Donors. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33123168 |keywords=* HIV * T cell * aging * immune activation * immune dysfunction * inflammation * monocyte |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573236 }} {{medline-entry |title=HIV and three dimensions of Wisdom: Association with cognitive function and physical and mental well-being: For: Psychiatry Research. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33096437 |keywords=* Affective * Aging * Aids * Compassion * Reflective |full-text-url=https://sci-hub.do/10.1016/j.psychres.2020.113510 }} {{medline-entry |title=CD8 T cells are present at low levels in the white matter with physiological and pathological aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33049712 |keywords=* aging * neuroscience * pathology |full-text-url=https://sci-hub.do/10.18632/aging.104043 }} {{medline-entry |title=Immunotherapy in older patients with cancer. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33041248 |keywords=* Ageing * Cancer * Elderly * Immunosenescence * Immunotherapy * Old people * Oncogeriatry |full-text-url=https://sci-hub.do/10.1016/j.bj.2020.07.009 }} {{medline-entry |title=Multiple genetic programs contribute to [[CD4]] T cell memory differentiation and longevity by maintaining T cell quiescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32987276 |keywords=* CD4 T cell * Cell longevity * Gene * Genetic programs * Memory T cell * Memory cell markers |full-text-url=https://sci-hub.do/10.1016/j.cellimm.2020.104210 }} {{medline-entry |title=Conventional Treatment for Multiple Myeloma Drives Premature Aging Phenotypes and Metabolic Dysfunction in T Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33013907 |keywords=* T cell * aging * autologous stem cell transplant * metabolism * myeloma |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494758 }} {{medline-entry |title=Immunosenescence: the role of age in multiple sclerosis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32962809 |keywords=* Ageing * Envejecimiento * Esclerosis múltiple * Esclerosis múltiple de comienzo tardío * Immunosenescence * Inmunosenescencia * Late-onset multiple sclerosis * Multiple sclerosis |full-text-url=https://sci-hub.do/10.1016/j.nrl.2020.05.016 }} {{medline-entry |title=Umbilical cord mesenchymal stem cells protect thymus structure and function in aged C57 mice by downregulating aging-related genes and upregulating autophagy- and anti-oxidative stress-related genes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32924972 |keywords=* aged * senescence * thymus * transplantation * umbilical cord mesenchymal stem cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521525 }} {{medline-entry |title=Impaired Cytotoxic CD8 T Cell Response in Elderly COVID-19 Patients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32948688 |mesh-terms=* Aged, 80 and over * Antigens, CD * Betacoronavirus * CD4-Positive T-Lymphocytes * CD8-Positive T-Lymphocytes * COVID-19 * Coronavirus Infections * Cytotoxins * Female * Humans * Immunity, Cellular * Male * Middle Aged * Pandemics * Pneumonia, Viral * SARS-CoV-2 * T-Lymphocyte Subsets * T-Lymphocytes, Cytotoxic |keywords=* CD4+ * CD8+ * COVID-19 * PD-1 * SARS-CoV-2 * aging * cytotoxic T cells * granzyme * perforin |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502863 }} {{medline-entry |title=What are the roles of antibodies versus a durable, high quality T-cell response in protective immunity against SARS-CoV-2? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32875286 |keywords=* Antibodies * Antibody-dependent enhancement * CD8 T-cells * COVID-19 * Durable immunity * Protective immunity * SARS * SARS-CoV-2 * T cell lifespan * T-cell epitopes * T-cells * Vaccines * Yellow Fever Vaccine |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452821 }} {{medline-entry |title=Per2 Upregulation in Circulating Hematopoietic Progenitor Cells During Chronic HIV Infection. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32850472 |keywords=* HIV * Sirtuin 1 * hematopoietic progenitor cells * period circadian clock 2 * senescence * telomere length |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396677 }} {{medline-entry |title=COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32802142 |keywords=* ACE2 * C-reactive protein * COVID-19 * Immunity * Immunosenescence * Interleukin-6 * Lymphocytes * Renin-angiotensin system * Severe acute respiratory syndrome coronavirus 2 * Spain |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426672 }} {{medline-entry |title=Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The Newcastle 85+ Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32735896 |keywords=* immunosenescence * lymphocyte compartments * physical performance * sarcopenia * very old adults |full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111321 }} {{medline-entry |title=Homeostasis and the functional roles of [[CD4]] Treg cells in aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32717201 |keywords=* Aging * Autoimmunity * Cancer * FOXP3 * Immune senescence * Immune suppression * Inflammaging * Regulatory T cells * T helper 17 * Treg |full-text-url=https://sci-hub.do/10.1016/j.imlet.2020.07.004 }} {{medline-entry |title=A Comprehensive Evaluation of the Impact of Bovine Milk Containing Different Beta-Casein Profiles on Gut Health of Ageing Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32707687 |keywords=* A2 beta-casein * SCFAs * elderly * gut inflammation * gut microbiota * gut morphology * immunosenescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400800 }} {{medline-entry |title=Premature aging of circulating T cells predicts all-cause mortality in hemodialysis patients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32660510 |keywords=* Hemodialysis * Inflammation * Mortality * T cell aging * naïve T cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359274 }} {{medline-entry |title=In-depth immune cellular profiling reveals sex-specific associations with frailty. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32582361 |keywords=* Frailty * Healthy aging * Immune cellular profiling * Immune homeostasis * Immunosenescence * Sex-specific immune profile |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310472 }} {{medline-entry |title=CD70 contributes to age-associated T cell defects and overwhelming inflammatory responses. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32559178 |keywords=* CD70 * T cell aging * co-inhibitory molecules * immunosenescence * overwhelming inflammatory responses |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343466 }} {{medline-entry |title=Comparison of Overall and Comorbidity-Free Life Expectancy Between Insured Adults With and Without HIV Infection, 2000-2016. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32539152 |mesh-terms=* Adult * Chronic Disease * Cohort Studies * Comorbidity * Female * HIV Infections * Humans * Insurance, Health * Life Expectancy * Male * Middle Aged |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296391 }} {{medline-entry |title=Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32545199 |keywords=* aging * dry eye * inflammation * lacrimal glands * meibomian glands * oxidative stress * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313015 }} {{medline-entry |title=Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32506584 |keywords=* senescence * thymic epithelial cells * thymocytes |full-text-url=https://sci-hub.do/10.1002/dvdy.212 }} {{medline-entry |title=CD8 T-cell senescence and skewed lymphocyte subsets in young Dyskeratosis Congenita patients with PARN and DKC1 mutations. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32452087 |keywords=* DKC1 * PARN * Dyskeratosis Congenita * primary immunodeficiency * senescence * telomere |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521304 }} {{medline-entry |title=Short-Term Environmental Enrichment is a Stronger Modulator of Brain Glial Cells and Cervical Lymph Node T Cell Subtypes than Exercise or Combined Exercise and Enrichment. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32451728 |keywords=* Aging * Astrocytes * Environmental enrichment * Microglia * Physical exercise * T cells |full-text-url=https://sci-hub.do/10.1007/s10571-020-00862-x }} {{medline-entry |title=Viral and host factors related to the clinical outcome of COVID-19. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32434211 |mesh-terms=* Adolescent * Adult * Aged * Aged, 80 and over * Aging * Animals * Asymptomatic Infections * Betacoronavirus * COVID-19 * China * Cohort Studies * Coronavirus Infections * Critical Illness * Disease Progression * Evolution, Molecular * Female * Genetic Variation * Genome, Viral * Hospitalization * Host-Pathogen Interactions * Humans * Inflammation Mediators * Interleukin-6 * Interleukin-8 * Lymphocyte Count * Lymphopenia * Male * Middle Aged * Pandemics * Phylogeny * Pneumonia, Viral * Respiratory Distress Syndrome * SARS-CoV-2 * T-Lymphocytes * Time Factors * Treatment Outcome * Virulence * Virus Shedding * Young Adult * Zoonoses |full-text-url=https://sci-hub.do/10.1038/s41586-020-2355-0 }} {{medline-entry |title=Use of comedications and potential drug-drug interactions in people living with HIV in China. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32354599 |keywords=* Aging * China * Co-medication * Drug-drug interaction * HIV |full-text-url=https://sci-hub.do/10.1016/j.jiac.2020.04.003 }} {{medline-entry |title=[[CD4]] T helper 17 cell response of aged mice promotes prostate cancer cell migration and invasion. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32356608 |mesh-terms=* Aging * Animals * CD4-Positive T-Lymphocytes * Cell Differentiation * Cell Line, Tumor * Cell Movement * Humans * Inflammation * Male * Mice * Mice, Inbred C57BL * Mice, Knockout * Models, Animal * NF-kappa B * Neoplasm Invasiveness * PC-3 Cells * Prostatic Neoplasms * Th17 Cells |keywords=* CD4+ T cell-secreted factors * PCa cells * Th17 cytokines * aging * inflammation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310589 }} {{medline-entry |title=The Rules of Human T Cell Fate [i]in vivo[/i]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32322253 |keywords=* decision * fate * half-life * labeling * lifespan * lymphocyte * mathematical model * proliferation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156550 }} {{medline-entry |title=[[CD4]]/CD8 ratio, comorbidities, and aging in treated HIV infected individuals on viral suppression. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32314818 |keywords=* CD4/CD8 ratio * HIV * aging * comorbidities |full-text-url=https://sci-hub.do/10.1002/jmv.25911 }} {{medline-entry |title=The effects of advanced maternal age on T-cell subsets at the maternal-fetal interface prior to term labor and in the offspring: a mouse study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32279324 |mesh-terms=* Adult * Aging * Animals * Female * Humans * Live Birth * Mice * Mice, Transgenic * Placenta * Pregnancy * T-Lymphocyte Subsets |keywords=* birth weight * neonate * offspring * pregnancy * preterm labor |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290081 }} {{medline-entry |title=Structural and Functional Changes in the Mesenteric Lymph Nodes in Humans during Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32248450 |keywords=* age-related involution * aging * immune system * immunomorphology * mesenteric lymph nodes |full-text-url=https://sci-hub.do/10.1007/s10517-020-04782-0 }} {{medline-entry |title=Neurocognitive Functioning is Associated with Self-Reported and Performance-Based Treatment Management Abilities in People Living with HIV with Low Health Literacy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32090235 |mesh-terms=* Adult * Cognition * Cross-Sectional Studies * HIV Infections * Health Literacy * Humans * Neuropsychological Tests * Self Report |keywords=* Adherence * Aging * Cognitive impairment * HIV/AIDS * Health illiteracy * Observational study |full-text-url=https://sci-hub.do/10.1093/arclin/acaa005 }} {{medline-entry |title=Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32064174 |keywords=* Stat3 * immune checkpoint blockade * immunotherapy * oncogene addiction * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996562 }} {{medline-entry |title=Age-related changes in T lymphocytes of patients with head and neck squamous cell carcinoma. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32082401 |keywords=* Aging * Head and neck cancer * Immune escape * Immunosenescence * T cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017629 }} {{medline-entry |title=Immunological history governs human stem cell memory [[CD4]] heterogeneity via the Wnt signaling pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32041953 |mesh-terms=* Aging * Animals * Antigens, CD * CD4-Positive T-Lymphocytes * Gene Expression Profiling * HIV Infections * Humans * Immunologic Memory * Intercellular Signaling Peptides and Proteins * Mice * Precursor Cells, T-Lymphoid * Thymus Gland * Wnt Signaling Pathway * beta Catenin |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010798 }} {{medline-entry |title=Estimating HIV Management and Comorbidity Costs Among Aging HIV Patients in the United States: A Systematic Review. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32011956 |mesh-terms=* Anti-HIV Agents * CD4 Lymphocyte Count * Comorbidity * Cost-Benefit Analysis * HIV Infections * Health Care Costs * Humans * Life Expectancy * United States |full-text-url=https://sci-hub.do/10.18553/jmcp.2020.26.2.104 }} {{medline-entry |title=Sex Differences in People Aging With HIV. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32032279 |mesh-terms=* Aged * Aging * Alcohol Drinking * Body Composition * CD4 Lymphocyte Count * CD4-CD8 Ratio * CD4-Positive T-Lymphocytes * Cohort Studies * Cross-Sectional Studies * Female * Frailty * HIV Infections * Humans * Male * Middle Aged * Muscle Strength * Prospective Studies |full-text-url=https://sci-hub.do/10.1097/QAI.0000000000002259 }} {{medline-entry |title=Identification of Differentially Expressed miRNAs in the Response of Spleen [[CD4]] T Cells to Electroacupuncture in Senescence-Accelerated Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32026263 |mesh-terms=* Aging * Animals * Antagomirs * CD4-Positive T-Lymphocytes * Cell Differentiation * Cytokines * Down-Regulation * Electroacupuncture * Female * Gene Regulatory Networks * High-Throughput Nucleotide Sequencing * Male * Mice * Mice, Inbred C57BL * MicroRNAs * Sequence Analysis, RNA * Spleen * Up-Regulation |keywords=* CD4+ T cell * Deep sequencing * Electroacupuncture * Immunological aging * miRNA |full-text-url=https://sci-hub.do/10.1007/s12013-020-00900-x }} {{medline-entry |title=Thymus Involution and Intravenous Drug Abuse. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32000220 |mesh-terms=* Adolescent * Adult * Aging * Atrophy * CD4-Positive T-Lymphocytes * CD8-Positive T-Lymphocytes * Calcinosis * Case-Control Studies * Drug Users * Female * Forensic Pathology * Hepatitis C, Chronic * Humans * Male * Middle Aged * Substance Abuse, Intravenous * Thymus Gland * Young Adult |full-text-url=https://sci-hub.do/10.1097/PAF.0000000000000530 }} {{medline-entry |title=Depletion of [[CD4]] T cells provides therapeutic benefits in aged mice after ischemic stroke. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31954116 |mesh-terms=* Aging * Animals * Behavior, Animal * Brain Chemistry * Brain Ischemia * CD4-Positive T-Lymphocytes * Chemokines * Cytokines * Female * Infarction, Middle Cerebral Artery * Inflammation * Male * Mice * Mice, Inbred C57BL * Stroke * Treatment Outcome |keywords=* Age * CD4 T cells * CXCL10 * Inflammation * Stroke |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059209 }} {{medline-entry |title=Immunological and Virological Responses in Older HIV-Infected Adults Receiving Antiretroviral Therapy: An Evidence-Based Meta-Analysis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31913990 |mesh-terms=* Aged * Aging * Anti-HIV Agents * HIV Infections * Humans * Middle Aged |full-text-url=https://sci-hub.do/10.1097/QAI.0000000000002266 }} {{medline-entry |title=African Mitochondrial DNA Haplogroup L2 Is Associated With Slower Decline of β-cell Function and Lower Incidence of Diabetes Mellitus in Non-Hispanic, Black Women Living With Human Immunodeficiency Virus. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31927570 |keywords=* HIV * aging * diabetes mellitus * mitochondrial genetics |full-text-url=https://sci-hub.do/10.1093/cid/ciaa026 }} {{medline-entry |title=DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31893939 |mesh-terms=* Aged * Aging * Animals * Antihypertensive Agents * CD4-Positive T-Lymphocytes * Cyclic AMP-Dependent Protein Kinases * Cytokines * Humans * Hypertension * Mice * Mice, Inbred C57BL * Nedd4 Ubiquitin Protein Ligases * Prostaglandin D2 * Receptors, Prostaglandin * Signal Transduction * Sp1 Transcription Factor * Superoxides * T-Box Domain Proteins * Th1 Cells * Ubiquitination |keywords=* D-prostanoid receptor 1 * aging * hypertension * lymphocyte * prostaglandin (PG) D2 |full-text-url=https://sci-hub.do/10.1161/CIRCULATIONAHA.119.042532 }} {{medline-entry |title=An Emerging Concern-High Rates of Frailty among Middle-aged and Older Individuals Living with HIV. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31885759 |keywords=* accelerated aging * anti-retroviral therapy * frailty * frailty index * geriatric syndrome * human immunodeficiency virus (HIV) * multimorbidity * vulnerability |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887139 }} {{medline-entry |title=Higher Acuity Resource Utilization With Older Age and Poorer HIV Control in Adolescents and Young Adults in the HIV Research Network. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31904706 |mesh-terms=* Adolescent * Adult * Aging * Anti-Retroviral Agents * CD4 Lymphocyte Count * Drug Administration Schedule * Female * HIV Infections * HIV-1 * Humans * Male * Medication Adherence * Viral Load * Young Adult |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055514 }} {{medline-entry |title=Mitochondrial DNA Haplogroups and Frailty in Adults Living with HIV. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31822125 |keywords=* HIV * aging * frailty * haplotypes * mitochondria * sarcopenia |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133433 }} {{medline-entry |title=Gallic acid attenuates thymic involution in the d-galactose induced accelerated aging mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31822433 |keywords=* Aging * FoxN1 * Gallic acid * Thymus * d-galactose |full-text-url=https://sci-hub.do/10.1016/j.imbio.2019.11.005 }} {{medline-entry |title=Mitochondrial mass governs the extent of human T cell senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31788930 |mesh-terms=* Adenosine Triphosphate * Adult * CD4-Positive T-Lymphocytes * CD8-Positive T-Lymphocytes * Cell Movement * Cell Proliferation * Cellular Senescence * Glucose * Glycolysis * Humans * Immunosenescence * Leukocyte Common Antigens * Microscopy, Electron, Transmission * Middle Aged * Mitochondria * Rotenone |keywords=* T cell * aging * metabolism * mitochondria * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996952 }} {{medline-entry |title=T cells and immune functions of plasma extracellular vesicles are differentially modulated from adults to centenarians. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31785146 |mesh-terms=* Adult * Aged * Aged, 80 and over * Extracellular Vesicles * Female * Humans * Immunosenescence * Lymphocyte Activation * Male * Middle Aged * T-Lymphocytes |keywords=* T cells * aging * centenarians * extracellular vesicles (EVs) * immunosenescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914389 }} {{medline-entry |title=Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31747595 |mesh-terms=* Aging * Animals * CD4-Positive T-Lymphocytes * CD8-Positive T-Lymphocytes * Disease Models, Animal * Lymphocytic Choriomeningitis * Lymphocytic choriomeningitis virus * Mice * MicroRNAs |keywords=* CD8 effector T cell * T cell repertoire * antiviral response * immune aging * immunosenescence * microRNA |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957231 }} {{medline-entry |title=Increased Prevalence of Neurocognitive Impairment in Aging People Living With Human Immunodeficiency Virus: The ANRS EP58 HAND 55-70 Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31755936 |keywords=* Frascati criteria * HAND * HIV * aging * neurocognitive impairment |full-text-url=https://sci-hub.do/10.1093/cid/ciz670 }} {{medline-entry |title=Age-associated changes in human [[CD4]] T cells point to mitochondrial dysfunction consequent to impaired autophagy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31707363 |mesh-terms=* Adult * Aged * CD4-Positive T-Lymphocytes * Cell Respiration * Humans * Immunosenescence * Longitudinal Studies * Mitochondria * Mitophagy * Young Adult |keywords=* CD4+ T cells * aging * autophagy * mitochondria * proteomics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874450 }} {{medline-entry |title=Sex Differences in the Blood Transcriptome Identify Robust Changes in Immune Cell Proportions with Aging and Influenza Infection. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31722210 |mesh-terms=* Aging * CD4-Positive T-Lymphocytes * Female * Humans * Influenza, Human * Male * Monocytes * Sex Characteristics * Transcriptome |keywords=* CD4(+) T cells * aging * immune system * immunology * influenza * meta-analysis * monocytes * multi-cohort analysis * sex differences * transcriptome |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856718 }} {{medline-entry |title=Going Beyond Giving Antiretroviral Therapy: Multimorbidity in Older People Aging with HIV in Nigeria. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31711310 |keywords=* ART * PLWH * aging * multimorbidity * quality of life |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071065 }} {{medline-entry |title=Alterations in composition of immune cells and impairment of anti-tumor immune response in aged oral cancer-bearing mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31683168 |mesh-terms=* Aged * Animals * Cell Line, Tumor * Cell Proliferation * Female * Humans * Immunotherapy * Mice |keywords=* Aging * Immune check-point molecules * Immunosenescence * Immunotherapy * Myeloid derived suppressor cells * Oral cancer * Regulatory T cells |full-text-url=https://sci-hub.do/10.1016/j.oraloncology.2019.104462 }} {{medline-entry |title=LTA1 is a safe, intranasal enterotoxin-based adjuvant that improves vaccine protection against influenza in young, old and B-cell-depleted (μMT) mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31641151 |mesh-terms=* Adjuvants, Immunologic * Administration, Intranasal * Aging * Animals * Antibodies * Antibody Formation * B-Lymphocytes * CD4-Positive T-Lymphocytes * Dose-Response Relationship, Immunologic * Enterotoxins * Female * Immunity, Mucosal * Immunization * Inflammation * Influenza A Virus, H1N1 Subtype * Lung * Lymphocyte Activation * Lymphocyte Depletion * Mast Cells * Mice, Inbred C57BL * Orthomyxoviridae Infections |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805908 }} {{medline-entry |title=Thymus Imaging Detection and Size Is Inversely Associated With Metabolic Syndrome and Frailty in People With HIV. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31660382 |keywords=* HIV * aging * frailty * metabolic syndrome * thymus |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6809752 }} {{medline-entry |title=Alterations in peripheral T cell and B cell subsets in patients with osteoarthritis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31624962 |mesh-terms=* Aged * Aging * B-Lymphocyte Subsets * Case-Control Studies * Female * Humans * Male * Middle Aged * Osteoarthritis, Knee * T-Lymphocyte Subsets |keywords=* B cell * Lymphocyte * Osteoarthritis * T cell |full-text-url=https://sci-hub.do/10.1007/s10067-019-04768-y }} {{medline-entry |title=Short Communication: Carotid Intima-Media Thickness Is Not Associated with Neurocognitive Impairment Among People Older than 50 Years With and Without HIV Infection from Thailand. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31588776 |mesh-terms=* Aging * Anti-Retroviral Agents * Cardiovascular Diseases * Carotid Intima-Media Thickness * Cross-Sectional Studies * Depression * Female * HIV Infections * Humans * Male * Middle Aged * Neurocognitive Disorders * Quality of Life * Risk Factors * Thailand |keywords=* HIV * aging * carotid intima-media thickness * neurocognitive |full-text-url=https://sci-hub.do/10.1089/AID.2019.0139 }} {{medline-entry |title=Implications of Immune Checkpoint Expression During Aging in HIV-Infected People on Antiretroviral Therapy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31578868 |mesh-terms=* Adult * Aged * Aging * Anti-HIV Agents * Antiretroviral Therapy, Highly Active * CD4-Positive T-Lymphocytes * CD8-Positive T-Lymphocytes * Cytokines * Female * Flow Cytometry * Gene Expression * HIV Infections * HIV-1 * Hepatitis A Virus Cellular Receptor 2 * Humans * Leukocytes, Mononuclear * Male * Middle Aged * Young Adult * gag Gene Products, Human Immunodeficiency Virus |keywords=* aging * immune checkpoint molecules * virus suppression |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862963 }} {{medline-entry |title=Age-related alterations in human gut [[CD4]] T cell phenotype, T helper cell frequencies, and functional responses to enteric bacteria. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31573727 |mesh-terms=* Adolescent * Adult * Age Factors * Aged * Aged, 80 and over * CD4-Positive T-Lymphocytes * Female * Gastrointestinal Microbiome * Humans * Interleukin-17 * Intestinal Mucosa * Male * Middle Aged * Phenotype * Th1 Cells * Th17 Cells * Young Adult |keywords=* T helper cells * aging * gut * human |full-text-url=https://sci-hub.do/10.1002/JLB.5A0919-177RR }} {{medline-entry |title=Determinants of blood telomere length in antiretroviral treatment-naïve HIV-positive participants enrolled in the NEAT 001/ANRS 143 clinical trial. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31532902 |mesh-terms=* Adult * Aged * Anti-Retroviral Agents * Cross-Sectional Studies * Darunavir * Emtricitabine * Female * HIV Infections * Humans * Logistic Models * Male * Middle Aged * RNA, Viral * Raltegravir Potassium * Ritonavir * Telomere * Tenofovir |keywords=* HIV infection * aging * immunosenescence * telomere length * viral load |full-text-url=https://sci-hub.do/10.1111/hiv.12791 }} {{medline-entry |title=Human T Cell Differentiation Negatively Regulates Telomerase Expression Resulting in Reduced Activation-Induced Proliferation and Survival. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31497023 |mesh-terms=* Adult * Cell Differentiation * Cell Proliferation * Cell Survival * Humans * T-Lymphocytes * Telomerase |keywords=* T cell subsets * T lymphocytes * aging * alternative splicing * differentiation * hTERT * proliferation * telomerase |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712505 }} {{medline-entry |title=Short Communication: Getting Older with HIV: Increasing Frequency of Comorbidities and Polypharmacy in Brazilian HIV Patients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31452382 |mesh-terms=* Aged * Aging * Brazil * CD4 Lymphocyte Count * Cardiovascular Diseases * Comorbidity * Diabetes Mellitus * Female * HIV Infections * Humans * Life Expectancy * Male * Middle Aged * Neoplasms * Polypharmacy |keywords=* Brazil * HIV * aging * noncommunicable diseases |full-text-url=https://sci-hub.do/10.1089/AID.2019.0069 }} {{medline-entry |title=Gait Speed Decline Is Associated with Hemoglobin A1C, Neurocognitive Impairment, and Black Race in Persons with HIV. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31468979 |mesh-terms=* Adult * African Americans * Aging * CD4 Lymphocyte Count * Cohort Studies * Female * Glycated Hemoglobin A * HIV Infections * Humans * Longitudinal Studies * Male * Middle Aged * Neurocognitive Disorders * Odds Ratio * RNA, Viral * Risk Factors * Walking Speed |keywords=* aging * gait speed * hemoglobin A1C * neurocognitive impairment |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862955 }} {{medline-entry |title=Noncommunicable Diseases Burden and Risk Factors in a Cohort of HIV+ Elderly Patients in Malawi. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31468993 |mesh-terms=* Adult * Age Factors * Aged * Anti-HIV Agents * Anti-Retroviral Agents * CD4 Lymphocyte Count * Comorbidity * Cost of Illness * Cross-Sectional Studies * Diabetes Mellitus * Female * HIV Infections * Humans * Hypertension * Malawi * Male * Middle Aged * Noncommunicable Diseases * Odds Ratio * Prevalence * Retrospective Studies * Risk Factors |keywords=* HIV infection * Malawi * aging * noncommunicable diseases |full-text-url=https://sci-hub.do/10.1089/AID.2019.0125 }} {{medline-entry |title=Aging promotes reorganization of the [[CD4]] T cell landscape toward extreme regulatory and effector phenotypes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31457092 |mesh-terms=* Aging * Animals * CD4-Positive T-Lymphocytes * High-Throughput Nucleotide Sequencing * Immunomodulation * Mice * Phenotype * Sequence Analysis, RNA * Single-Cell Analysis * T-Lymphocyte Subsets |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703865 }} {{medline-entry |title=Prevalence of hypertension and cardiovascular risk factors among long-term AIDS survivors: A report from the field. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31448551 |mesh-terms=* Acquired Immunodeficiency Syndrome * Adult * Anti-Retroviral Agents * CD4 Lymphocyte Count * Cardiovascular Diseases * Diabetes Mellitus * Diagnostic Screening Programs * Female * HIV Infections * HIV-1 * Haiti * Humans * Hypercholesterolemia * Hypertension * Male * Middle Aged * Obesity * Prevalence * Retrospective Studies * Risk Factors * Smoking * Survivors |keywords=* HIV * aging * cardiovascular disease * hypertension * risk assessment |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896990 }} ==CD44== {{medline-entry |title=Hyaluronan goes to great length. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32908962 |keywords=* aging * hyaluronan * longevity * naked mole rat * very high molecular weight hyaluronan |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453635 }} {{medline-entry |title=Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32398747 |mesh-terms=* Animals * Apoptosis * Cell Cycle Checkpoints * Cell Line * Cytoprotection * Gene Expression Regulation * Gene Knockout Techniques * Humans * Hyaluronan Receptors * Hyaluronic Acid * Longevity * Mice * Mole Rats * Molecular Weight * Primary Cell Culture * Protein Interaction Maps * RNA-Seq * Signal Transduction * Species Specificity * Stress, Physiological * Tumor Suppressor Protein p53 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217962 }} {{medline-entry |title=Maturity-dependent cartilage cell plasticity and sensitivity to external perturbation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32321631 |keywords=* Aging * Articular cartilage * Osteoarthritis * Plasticity * Progenitor cells |full-text-url=https://sci-hub.do/10.1016/j.jmbbm.2020.103732 }} {{medline-entry |title=Aged Mice Exhibit Severe Exacerbations of Dry Eye Disease with an Amplified Memory Th17 Cell Response. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32289288 |mesh-terms=* Aging * Animals * Dry Eye Syndromes * Female * Immunologic Memory * Mice * Mice, Inbred C57BL * Th17 Cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369573 }} {{medline-entry |title=Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32054990 |mesh-terms=* Animals * B-Lymphocytes * Cellular Senescence * Circadian Rhythm * Disease Models, Animal * Humans * Hyaluronan Receptors * Inflammation * Jet Lag Syndrome * Longevity * Mice * Programmed Cell Death 1 Receptor * Sequence Analysis, RNA * T-Lymphocytes |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018741 }} {{medline-entry |title=Defective induction of the proteasome associated with T-cell receptor signaling underlies T-cell senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31621149 |mesh-terms=* Animals * CD4-Positive T-Lymphocytes * Cell Proliferation * Cells, Cultured * Cellular Senescence * Cytokines * Hyaluronan Receptors * Mice * Mice, Inbred C57BL * Phenotype * Programmed Cell Death 1 Receptor * Proteasome Endopeptidase Complex * Receptors, Antigen, T-Cell * Signal Transduction |keywords=* T cell receptor signal * T cell senescence * aging * proteasome |full-text-url=https://sci-hub.do/10.1111/gtc.12728 }} ==CD47== {{medline-entry |title=Aging-associated changes in [[CD47]] arrangement and interaction with thrombospondin-1 on red blood cells visualized by super-resolution imaging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32866348 |keywords=* CD47 * aging * dSTORM * red blood cells * thrombospondin-1 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576236 }} {{medline-entry |title=[[CD47]] Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32679764 |keywords=* CD47 * aging * angiogenesis * blood flow * endothelial cells * glucose homeostasis * metabolism * self-renewal * thrombospondin-1 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407670 }} {{medline-entry |title=Unique Spatial Immune Profiling in Pancreatic Ductal Adenocarcinoma with Enrichment of Exhausted and Senescent T Cells and Diffused [[CD47]]-SIRPα Expression. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32645996 |keywords=* CD47 * T cell exhaustion * T cell senescence * draining lymph nodes * macrophage checkpoint * neoadjuvant chemotherapy * pancreatic ductal adenocarcinoma * signal regulatory protein alpha (SIRPα) * spatial heterogeneity * tumor microenvironment |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408661 }} ==CD5== {{medline-entry |title=Comparative proteomic analysis identifies biomarkers for renal aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33159023 |keywords=* NMN * biomarkers * glutathionylation * proteomics * renal aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695359 }} ==CD63== {{medline-entry |title=Cellular senescence contributes to age-dependent changes in circulating extracellular vesicle cargo and function. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31960578 |keywords=* aging * extracellular vesicles * microRNA * plasma * senescence * senolytic |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059145 }} ==CD68== {{medline-entry |title=Insulin activates microglia and increases COX-2/IL-1β expression in young but not in aged hippocampus. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32422127 |keywords=* Aging * Hippocampus * Insulin * Memory * Microglia * Neuroinflammation |full-text-url=https://sci-hub.do/10.1016/j.brainres.2020.146884 }} {{medline-entry |title=Epigenetic modulation of macrophage polarization prevents lumbar disc degeneration. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32310825 |keywords=* DNA methyltransferase 1 (DNMT1) * aging * lumbar disc degeneration (LDD) * macrophage polarization * transforming growth factor beta 1 (TGFβ1) |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202517 }} {{medline-entry |title=Cellular senescence in recurrent tonsillitis and tonsillar hypertrophy in children. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32200310 |mesh-terms=* Antigens, CD * Antigens, Differentiation, Myelomonocytic * Cellular Senescence * Child * Germinal Center * Humans * Hypertrophy * Macrophages * Palatine Tonsil * Recurrence * Tonsillectomy * Tonsillitis |keywords=* Cellular senescence * Recurrent tonsillitis * Tonsillar hypertrophy |full-text-url=https://sci-hub.do/10.1016/j.ijporl.2020.110004 }} {{medline-entry |title=Ginsenoside Rg1 supplementation clears senescence-associated β-galactosidase in exercising human skeletal muscle. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31695564 |keywords=* Cellular senescence * Endurance * Ergogenic aid * Inflammation * Macrophage |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823780 }} {{medline-entry |title=Histopathological, immunohistochemical, and molecular studies for determination of wound age and vitality in rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31448552 |mesh-terms=* Actins * Animals * Antigens, CD * Antigens, Differentiation, Myelomonocytic * Cell Movement * Fibroblasts * Granulation Tissue * Immunohistochemistry * Macrophages * Models, Animal * Neovascularization, Physiologic * RNA, Messenger * Rats, Wistar * Re-Epithelialization * Skin * Time Factors * Transforming Growth Factor beta1 * Vascular Endothelial Growth Factor A * Wound Healing * Wounds and Injuries |keywords=* TGFb1 * VEGF * gene expression * immunohistochemistry * wound aging |full-text-url=https://sci-hub.do/10.1111/iwj.13206 }} ==CD80== {{medline-entry |title=The aging common marmoset's immune system: From junior to senior. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32246726 |mesh-terms=* Aging * Animals * CD4-CD8 Ratio * Callithrix * Female * Flow Cytometry * Immune System * Longevity * Male * Models, Animal * Sex Factors |keywords=* aging * common marmoset * immune system * immunosenescence * innate and adaptive immunity * sex |full-text-url=https://sci-hub.do/10.1002/ajp.23128 }} ==CD81== {{medline-entry |title=Ovarian aging increases small extracellular vesicle [[CD81]] release in human follicular fluid and influences miRNA profiles. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32554857 |keywords=* extracellular vesicles * follicular fluid * microRNAs * reproductive aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343446 }} {{medline-entry |title=Older Adults with Physical Frailty and Sarcopenia Show Increased Levels of Circulating Small Extracellular Vesicles with a Specific Mitochondrial Signature. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32326435 |keywords=* aging * biomarkers * exosomes * mitochondrial dynamics * mitochondrial quality control * mitochondrial-derived vesicles (MDVs) * mitochondrial-lysosomal axis * mitophagy |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227017 }} {{medline-entry |title=Increased production of functional small extracellular vesicles in senescent endothelial cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32101370 |keywords=* endothelium * exosomes * extracellular vesicles * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176858 }} ==CDA== {{medline-entry |title=Cumulative Dis/Advantage and Health Pattern in Late Life: A Comparison between Genders and Welfare State Regimes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31771483 |mesh-terms=* Aged * Aged, 80 and over * China * Cross-Sectional Studies * England * Female * Health Behavior * Health Status Disparities * Humans * Longevity * Male * Mexico * Middle Aged * Regression Analysis * Self Report * Sex Factors * Social Class * Social Welfare * United States |keywords=* Cumulative dis/advantage * cross-national study * health retirement study * welfare state theory |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367435 }} {{medline-entry |title=Does numerical similarity alter age-related distractibility in working memory? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31483830 |mesh-terms=* Adult * Aged * Aging * Alpha Rhythm * Attention * Evoked Potentials * Female * Healthy Volunteers * Humans * Male * Memory, Short-Term * Young Adult |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726243 }} ==CDC20== {{medline-entry |title=Premature aging syndrome showing random chromosome number instabilities with [[CDC20]] mutation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33094908 |keywords=* Cdc20 proteins * M phase cell cycle checkpoints * aging * chromosomal instability * chromosome segregation * genomic instability * premature |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681047 }} ==CDC25A== {{medline-entry |title=Babam2 Regulates Cell Cycle Progression and Pluripotency in Mouse Embryonic Stem Cells as Revealed by Induced DNA Damage. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33050379 |keywords=* Babam2 * DNA damage * cell cycle * embryonic stem cells * pluripotency * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600899 }} ==CDC42== {{medline-entry |title=Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through YAP1. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31487690 |mesh-terms=* Adaptor Proteins, Signal Transducing * Adult * Aging * Animals * Cell Cycle Proteins * Cell Size * Endothelial Cells * Female * Humans * Male * Mice, Inbred C57BL * Middle Aged * Neovascularization, Physiologic * Primary Cell Culture * Transcription Factors * cdc42 GTP-Binding Protein |keywords=* aging * angiogenesis * cell proliferation * cell size * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756888 }} ==CDH1== {{medline-entry |title=Cdc6 as a novel target in cancer: Oncogenic potential, senescence and subcellular localisation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32010971 |keywords=* Cdc6 * cytoplasmic Cdc6 * pancreatic cancer * senescence * subcellular localisation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7496346 }} ==CDK1== {{medline-entry |title=MicroRNAomic Transcriptomic Analysis Reveal Deregulation of Clustered Cellular Functions in Human Mesenchymal Stem Cells During in Vitro Passaging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31848878 |mesh-terms=* CDC2-CDC28 Kinases * Cell Differentiation * Cell Proliferation * Cellular Senescence * Cyclin B * Gene Expression Regulation, Developmental * Humans * Mesenchymal Stem Cells * MicroRNAs * Transcriptome * Tumor Suppressor Protein p53 * Umbilical Cord |keywords=* Cell proliferation * Cell senescence * Cellular ageing * Human Mesenchymal stem / stromal cells * miRNA-mRNA integration |full-text-url=https://sci-hub.do/10.1007/s12015-019-09924-0 }} ==CDK2== {{medline-entry |title=p57 is a master regulator of human adipose derived stem cell quiescence and senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32224418 |keywords=* Human adipose derived stem cells * Quiescence * Senescence * p57(Kip2) |full-text-url=https://sci-hub.do/10.1016/j.scr.2020.101759 }} ==CDK4== {{medline-entry |title=Emerging Roles for the [i]INK4a/ARF[/i] ([i]CDKN2A[/i]) Locus in Adipose Tissue: Implications for Obesity and Type 2 Diabetes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32971832 |keywords=* adipogenesis * inflammation * insulin sensitivity * obesity * oxidative activity * senescence * type 2 diabetes |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563355 }} {{medline-entry |title=Guilu Erxian Glue () Inhibits Chemotherapy-Induced Bone Marrow Hematopoietic Stem Cell Senescence in Mice May via p16 -Rb Signaling Pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32915425 |keywords=* Chinese medicine * Guilu Erxian Glue * bone marrow suppression * hematopoietic stem cell senescence * p16INK4a |full-text-url=https://sci-hub.do/10.1007/s11655-020-3098-3 }} ==CDK5== {{medline-entry |title=Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31636448 |mesh-terms=* Aging * Animals * Cell Cycle * Cell Death * Cellular Senescence * Cyclin-Dependent Kinase 5 * Excitatory Postsynaptic Potentials * Gene Expression * Glycolysis * Hexokinase * Hyperinsulinism * Inhibitory Postsynaptic Potentials * Insulin * Insulin Resistance * Liraglutide * Male * Maze Learning * Metformin * Mice * Neurons * Phosphotransferases * Primary Cell Culture * Protein-Serine-Threonine Kinases * Ubiquitination * beta Catenin |full-text-url=https://sci-hub.do/10.1038/s41593-019-0505-1 }} ==CDK6== {{medline-entry |title=Saturated Fatty Acids Promote Hepatocytic Senecence through Regulation of miR-34a/Cyclin-Dependent Kinase 6. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32970940 |keywords=* cyclin-dependent kinase 6 (CDK6) * high-fat diet (HFD) * miR-34a * palmitate acid (PA) * senescence |full-text-url=https://sci-hub.do/10.1002/mnfr.202000383 }} {{medline-entry |title=Hepatoprotective effects of hydroxysafflor yellow A in D-galactose-treated aging mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32454116 |keywords=* D-galactose * Hydroxysafflor yellow A * Oxidative stress * Replicative senescence * p16 |full-text-url=https://sci-hub.do/10.1016/j.ejphar.2020.173214 }} {{medline-entry |title=Anti-cell growth and anti-cancer stem cell activity of the CDK4/6 inhibitor palbociclib in breast cancer cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31823286 |keywords=* Breast cancer * CDK4 * Cancer stem cells * Palbociclib * Senescence |full-text-url=https://sci-hub.do/10.1007/s12282-019-01035-5 }} {{medline-entry |title=Compromising the constitutive p16 expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31692039 |keywords=* 17AAG * Hsp90 * cancer * p16INK4a * senescence * tumor suppressor |full-text-url=https://sci-hub.do/10.1002/jcb.29493 }} ==CDKN1A== {{medline-entry |title=Involvement of [[CDKN1A]] (p21) in cellular senescence in response to heat and irradiation stress during preimplantation development. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32253738 |keywords=* Cdkn1a * Heat stress * Irradiation * Preimplantation * Senescence * p21 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193008 }} ==CDKN2A== {{medline-entry |title=Association between Nrf2 and [[CDKN2A]] expression in patients with end-stage renal disease: a pilot study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32661200 |keywords=* CDKN2A * Nrf2 * aging * end-stage renal disease * inflammation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485736 }} ==CDKN2B== {{medline-entry |title=Molecular Genetics and Functional Analysis Implicate [i][[CDKN2B]]AS1-[[CDKN2B]][/i] Involvement in POAG Pathogenesis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32825664 |keywords=* African Americans * CDKN2B-AS1 * Primary open-angle glaucoma (POAG) * senescence * trabecular meshwork cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564117 }} ==CFI== {{medline-entry |title=Psychosocial Resources for Hedonic Balance, Life Satisfaction and Happiness in the Elderly: A Path Analysis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32781590 |mesh-terms=* Adult * Aged * Aged, 80 and over * Aging * Cross-Sectional Studies * Female * Happiness * Health Status * Humans * Male * Personal Satisfaction * Quality of Life |keywords=* happiness * older adults * path analysis * psychosocial resources * subjective well-being |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459462 }} {{medline-entry |title=Validity and Reliability of the Flourishing Scale in a Sample of Older Adults in Iran. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32546985 |mesh-terms=* Aged * Aging * Cross-Sectional Studies * Female * Geriatric Assessment * Health Status Disparities * Humans * Iran * Male * Mental Health * Psychometrics * Reproducibility of Results * Surveys and Questionnaires |keywords=* aging * factor analysis * flourishing * reliability * validity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244746 }} {{medline-entry |title=The decision about retirement: A scale to describe representations and practices of medical doctors and nurses. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32258559 |keywords=* Aging * Job satisfaction * Retirement * Scale |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806742 }} {{medline-entry |title=Family versus intimate partners: Estimating who matters more for health in a 20-year longitudinal study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31697103 |mesh-terms=* Adult * Aged * Aging * Emotions * Family Relations * Female * Health Status * Humans * Interpersonal Relations * Longitudinal Studies * Male * Middle Aged * Sexual Partners * United States |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012715 }} {{medline-entry |title=Adapting and validating the Rosenberg Self-Esteem Scale for elderly Spanish population. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31524131 |keywords=* aging * life span * self-esteem * structural equation model * validity |full-text-url=https://sci-hub.do/10.1017/S1041610219001170 }} ==CFTR== {{medline-entry |title=Exercise Physiology Across the Lifespan in Cystic Fibrosis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31780953 |keywords=* aging * cystic fibrosis * exercise capacity * exercise prescription * pediatric |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856653 }} {{medline-entry |title=Reduced expression of the Ion channel [[CFTR]] contributes to airspace enlargement as a consequence of aging and in response to cigarette smoke in mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31477092 |mesh-terms=* Aging * Animals * Cystic Fibrosis Transmembrane Conductance Regulator * Gene Expression * Inhalation Exposure * Mice * Mice, Knockout * Pulmonary Emphysema * Tobacco Smoke Pollution |keywords=* Aging * CFTR * Emphysema * Smoking |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720379 }} ==CGA== {{medline-entry |title=Safety and efficacy of preoperative chemoradiotherapy in fit older patients with intermediate or locally advanced rectal cancer evaluated by comprehensive geriatric assessment: A planned interim analysis of a multicenter, phase II trial. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33160954 |keywords=* Comprehensive geriatric assessment * Geriatrics * Preoperative chemoradiotherapy * Rectal cancer |full-text-url=https://sci-hub.do/10.1016/j.jgo.2020.10.016 }} {{medline-entry |title=The Protective Effect of Chlorogenic Acid on Vascular Senescence via the Nrf2/HO-1 Pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32630570 |keywords=* chlorogenic acid * heme oxygenase-1 * nuclear factor erythroid 2-related factor 2 * vascular senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350250 }} {{medline-entry |title=Association between comprehensive geriatric assessment and short-term outcomes among older adult patients with stroke: A nationwide retrospective cohort study using propensity score and instrumental variable methods. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32566923 |keywords=* Comprehensive geriatric assessment * Geriatrics * Japanese diagnosis procedure combination database * Length of stay * Mortality * Stroke |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298723 }} {{medline-entry |title=Interventions to Improve Clinical Outcomes in Older Adults Admitted to a Surgical Service: A Systematic Review and Meta-analysis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32417101 |keywords=* Aging * comprehensive geriatric assessment * delirium * functional status * outcomes * surgery |full-text-url=https://sci-hub.do/10.1016/j.jamda.2020.03.023 }} {{medline-entry |title=A Computerized Frailty Assessment Tool at Points-of-Care: Development of a Standalone Electronic Comprehensive Geriatric Assessment/Frailty Index (eFI-[[CGA]]). |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32296673 |keywords=* aging * comprehensive geriatric assessment (CGA) * electronic assessment tools * frailty * frailty index * healthcare * older adults |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137764 }} {{medline-entry |title=Allocating patients to geriatric medicine wards in a tertiary university hospital in England: A service evaluation of the Specialist Advice for the Frail Elderly (SAFE) team. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31942488 |keywords=* clinical frailty scale * frail older adults * geriatrics * hospital medicine |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880728 }} {{medline-entry |title=Role of Frailty on Risk Stratification in Cardiac Surgery and Procedures. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31894551 |mesh-terms=* Aged * Aged, 80 and over * Cardiac Surgical Procedures * Frail Elderly * Frailty * Geriatric Assessment * Humans * Percutaneous Coronary Intervention * Risk Assessment * Transcatheter Aortic Valve Replacement |keywords=* Cardiac surgery * Comprehensive geriatric assessment * Disability * Elderly * Frailty * Geriatrics * Surgical risk scores * TAVI |full-text-url=https://sci-hub.do/10.1007/978-3-030-33330-0_11 }} {{medline-entry |title=Developing an objective structured clinical examination in comprehensive geriatric assessment - A pilot study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31745004 |mesh-terms=* Aged * Clinical Competence * Education, Medical, Graduate * Educational Measurement * Female * Geriatric Assessment * Geriatrics * Humans * Male * Pilot Projects * United Kingdom |keywords=* Comprehensive geriatric assessment * development * entrustable professional capabilities * objective structured clinical examination * summative assessment |full-text-url=https://sci-hub.do/10.4103/efh.EfH_111_18 }} {{medline-entry |title=How do doctors choose treatment for older gynecological cancer patients? A Japanese Gynecologic Oncology Group survey of gynecologic oncologists. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31728682 |mesh-terms=* Aged * Aged, 80 and over * Comorbidity * Female * Genital Neoplasms, Female * Geriatric Assessment * Gynecology * Humans * Hysterectomy * Japan * Lymph Node Excision * Oncologists * Surveys and Questionnaires |keywords=* Comprehensive geriatric assessment * Elderly * Geriatrics * Gynecologic cancer |full-text-url=https://sci-hub.do/10.1007/s10147-019-01574-z }} {{medline-entry |title=Validation of the Pictorial Fit-Frail Scale in a memory clinic setting. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31524122 |keywords=* aging * dementia * frail elderly * frailty * psychometrics |full-text-url=https://sci-hub.do/10.1017/S1041610219000905 }} {{medline-entry |title=Impact of Resolution of Hyponatremia on Neurocognitive and Motor Performance in Geriatric Patients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31467370 |mesh-terms=* Activities of Daily Living * Aged * Aged, 80 and over * Aging * Cognition * Female * Geriatrics * Humans * Hyponatremia * Male * Mental Status and Dementia Tests * Middle Aged * Motor Activity * Sodium |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715723 }} {{medline-entry |title=Health outcome of older hospitalized patients in internal medicine environments evaluated by Identification of Seniors at Risk (ISAR) screening and geriatric assessment. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31412787 |mesh-terms=* Accidental Falls * Aged * Aged, 80 and over * Cohort Studies * Emergency Service, Hospital * Female * Geriatric Assessment * Health Status * Hospitalization * Humans * Internal Medicine * Length of Stay * Male * Mass Screening * Patient Discharge * Risk Assessment |keywords=* CGA * Cutoff * Geriatrics * ISAR * Internal medicine * Older in-patients * Risk screening * Sensitivity * Specificity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694685 }} ==CHI3L1== {{medline-entry |title=Postsynaptic damage and microglial activation in AD patients could be linked CXCR4/CXCL12 expression levels. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32949560 |keywords=* Aging * Alzheimer’s disease * Bioinformatics * CHI3L1 * Chitinase * NRGN |full-text-url=https://sci-hub.do/10.1016/j.brainres.2020.147127 }} ==CHRNA7== {{medline-entry |title=Associations between genetic variations and global motion perception. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31432227 |mesh-terms=* Adult * Differential Threshold * Female * Genotype * Humans * Male * Motion Perception * Polymorphism, Single Nucleotide * Receptors, Nicotinic * Sensory Thresholds * Young Adult * alpha7 Nicotinic Acetylcholine Receptor |keywords=* Aging * CHRNA7 * Cholinergic system * Coherent motion * Genetic variations |full-text-url=https://sci-hub.do/10.1007/s00221-019-05627-7 }} ==CHSY1== {{medline-entry |title=Loss of Chondroitin Sulfate Modification Causes Inflammation and Neurodegeneration in [i]skt[/i] Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31754016 |mesh-terms=* Age Factors * Animals * Apoptosis * Chondroitin Sulfates * Female * Glucuronosyltransferase * Inflammation * Male * Mice * Mice, Inbred C57BL * Mice, Knockout * Multifunctional Enzymes * Mutation * N-Acetylgalactosaminyltransferases * Neurodegenerative Diseases * Neurons * Protein Processing, Post-Translational * Proteins * Retinal Degeneration |keywords=* aging * chondroitin sulfate synthase * hippocampus * inflammation * mouse * myeloid cells * neurodegeneration * retina * retinal pigment epithelium * subretinal space |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944401 }} ==CISD2== {{medline-entry |title=[[CISD2]] Attenuates Inflammation and Regulates Microglia Polarization in EOC Microglial Cells-As a Potential Therapeutic Target for Neurodegenerative Dementia. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33005144 |keywords=* CISD2 * M1/M2 microglia polarization * aging * anti-inflammatory effects * neurodegenerative disease and dementia |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479185 }} ==CIT== {{medline-entry |title=Effect of sex on aging-related decline of dopamine transporter in healthy subjects. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33052524 |keywords=* 123I-FP-CIT * Aging * Dopamine plasma membrane transport proteins * SPECT * Sex |full-text-url=https://sci-hub.do/10.1007/s12149-020-01538-8 }} {{medline-entry |title=The Relationship Between the Striatal Dopaminergic Neuronal and Cognitive Function With Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32184717 |keywords=* SPECT * Wechsler Adult Intelligence Scale * aging * cognitive function * dopamine transporter * verbal function |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058549 }} ==CLEC3B== {{medline-entry |title=[[CLEC3B]] p.S106G Mutant in a Caucasian Population of Successful Neurological Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31570938 |keywords=* APOE * CLEC3B * Aging * Human genetics * Human health |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494029 }} ==COL1A1== {{medline-entry |title=Remodeling process in bone of aged rats in response to resistance training. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32593709 |mesh-terms=* Age Factors * Aging * Animals * Bone Remodeling * Gene Expression Regulation * Male * Physical Conditioning, Animal * RNA, Messenger * Random Allocation * Rats * Rats, Wistar * Resistance Training |keywords=* Aging * Bone homeostasis * Function * Resistance training |full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118008 }} ==COL3A1== {{medline-entry |title=Different expression of Defensin-B gene in the endometrium of mares of different age during the breeding season. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31864349 |mesh-terms=* Aging * Animals * Breeding * Defensins * Endometrium * Female * Fibrosis * Gene Expression * Horses * Inflammation * Reverse Transcriptase Polymerase Chain Reaction |keywords=* Defensin-β * Endometrium * Gene expression * Immune-modulation * Mare |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925900 }} ==COMT== {{medline-entry |title=The geriatric pain experience in mice: intact cutaneous thresholds but altered responses to tonic and chronic pain. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32008855 |mesh-terms=* Acetone * Aging * Animals * Behavior * Biogenic Monoamines * Capsaicin * Chronic Pain * Disease Models, Animal * Male * Mice, Inbred C57BL * Peripheral Nerve Injuries * Physical Stimulation * Prefrontal Cortex * Sensory Thresholds |keywords=* Geriatric pain * Healthy aging * Mice * Sensory thresholds * Supraspinal plasticity * Tonic and chronic pain response |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2019.12.018 }} ==COPE== {{medline-entry |title=Patterns and characteristics of cognitive functioning in older patients approaching end stage kidney disease, the [[COPE]]-study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32272897 |keywords=* Cognitive function * End stage renal disease * Geriatric assessment * Geriatrics * Older patients |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147053 }} ==CORT== {{medline-entry |title=Sex differences in body composition, metabolism-related hormones, and energy homeostasis during aging in Wistar rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33075214 |keywords=* aging * body composition * energy metabolism * metabolism-related hormone * sex differences |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571994 }} {{medline-entry |title=Effects of age and social isolation on murine hippocampal biochemistry and behavior. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32866520 |keywords=* Aging * Hippocampus * Inflammation * Memory * Serotonin * Social isolation * Stress |full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111337 }} {{medline-entry |title=Interleukin 6 reduces allopregnanolone synthesis in the brain and contributes to age-related cognitive decline in mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32669383 |keywords=* Alzheimer’s disease * aging * cognitive function * enzyme regulation * inflammation * neurosteroid * progesterone * steroid hormones |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529050 }} {{medline-entry |title=Sex- and age-dependent differences in the hormone and drinking responses to water deprivation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31967852 |mesh-terms=* Age Factors * Animals * Arginine Vasopressin * Behavior, Animal * Dehydration * Drinking * Female * Male * Rats, Wistar * Sex Factors * Sodium Chloride * Subfornical Organ * Water Deprivation |keywords=* aging * hormonal response * sex differences * sodium appetite * thirst |full-text-url=https://sci-hub.do/10.1152/ajpregu.00303.2019 }} {{medline-entry |title=Ontogeny of the adrenocortical response in an extremely altricial bird. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31545013 |mesh-terms=* Adrenal Glands * Aging * Animals * Corticosterone * Female * Hypothalamo-Hypophyseal System * Male * Parrots * Restraint, Physical * Stress, Physiological |keywords=* Venezuela * adrenocortical * altricial * birds * corticosterone * glucocorticoid * hypothalamic-pituitary-adrenal axis * ontogeny * parrots * stress |full-text-url=https://sci-hub.do/10.1002/jez.2317 }} ==CP== {{medline-entry |title=A Life Course Perspective on Growing Older With Cerebral Palsy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33213304 |keywords=* aging * cerebral palsy * midlife * neurological disorders * neurology * qualitative descriptive |full-text-url=https://sci-hub.do/10.1177/1049732320971247 }} {{medline-entry |title=The molecular anatomy and functions of the choroid plexus in healthy and diseased brain. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32750317 |keywords=* Aging * Alzheimer's disease * Choroid plexus * Development * Multiple sclerosis * Neuroprotection |full-text-url=https://sci-hub.do/10.1016/j.bbamem.2020.183430 }} {{medline-entry |title=The effects and mechanism of collagen peptide and elastin peptide on skin aging induced by D-galactose combined with ultraviolet radiation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32717457 |keywords=* Collagen * D-galactose * Elastin * Skin aging * Ultraviolet |full-text-url=https://sci-hub.do/10.1016/j.jphotobiol.2020.111964 }} {{medline-entry |title=Model based strategies towards protein A resin lifetime optimization and supervision. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32709318 |mesh-terms=* Algorithms * Chromatography * Kinetics * Least-Squares Analysis * Ligands * Models, Theoretical * Principal Component Analysis * Resins, Plant * Staphylococcal Protein A * Statistics as Topic |keywords=* Cleaning procedures * Hybrid modeling * Multivariate data analysis * Protein A chromatography * Resin aging * Resin lifetime |full-text-url=https://sci-hub.do/10.1016/j.chroma.2020.461261 }} {{medline-entry |title=The influence of age and environmental conditions on supplement intake by beef cattle winter grazing northern mixed-grass rangelands. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32658282 |mesh-terms=* Aging * Animal Feed * Animal Husbandry * Animals * Cattle * Diet * Dietary Supplements * Ecosystem * Female * Poaceae * Seasons * Weather |keywords=* beef cattle * cow age * environment * supplement intake * winter grazing |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455287 }} {{medline-entry |title=Cyclophosphamide, a cancer chemotherapy drug-induced early onset of reproductive senescence and alterations in reproductive performance and their prevention in mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32536211 |keywords=* Cyclophosphamide * Decalepis hamiltonii * premature ovarian failure * reproductive performance * reproductive senescence * uterus |full-text-url=https://sci-hub.do/10.1080/01480545.2020.1774773 }} {{medline-entry |title=Asymptomatic [i]Clostridium perfringens[/i] Inhabitation in Intestine Can Cause Inflammation, Apoptosis, and Disorders in Brain. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31928429 |mesh-terms=* Aging * Animals * Apoptosis * Asymptomatic Infections * Brain * Brain Diseases * Clostridium Infections * Clostridium perfringens * Disease Models, Animal * Feces * Food Microbiology * Gene Expression * Humans * Inflammation * Intestines * Liver * Male * Mice * Mice, Inbred C57BL * Organ Size * Oxidative Stress * Risk Factors * Spleen |keywords=* Clostridium perfringens * brain damage * brain disorder * gut microbiota |full-text-url=https://sci-hub.do/10.1089/fpd.2019.2677 }} {{medline-entry |title=The Role of the Clinical Pharmacist in the Management of People Living with HIV in the Modern Antiretroviral Era. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31834321 |mesh-terms=* Aged * Aged, 80 and over * Anti-Retroviral Agents * Disease Management * Disease Transmission, Infectious * Female * HIV Infections * Humans * Male * Medication Adherence * Middle Aged * Pharmacists * Professional Role * Treatment Outcome |keywords=* Aging * Antiretroviral therapy * Clinical pharmacist * Comorbidities * HIV |full-text-url=https://sci-hub.do/10.24875/AIDSRev.19000089 }} {{medline-entry |title=A clinically feasible method for the assessment and characterization of pain in patients with chronic pancreatitis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31787527 |mesh-terms=* Adult * Aging * Case-Control Studies * Cross-Sectional Studies * Humans * Middle Aged * Pain * Pain Measurement * Pancreatitis, Chronic * Sex Factors |keywords=* Central sensitization * Chronic pancreatitis * Nociception * Pain |full-text-url=https://sci-hub.do/10.1016/j.pan.2019.11.007 }} {{medline-entry |title=Differences in geometric strength at the contralateral hip between men with hip fracture and non-fractured comparators. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31812699 |keywords=* Aging * DXA * Fracture prevention * Injury/fracture healing * Osteoporosis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037571 }} {{medline-entry |title=Factors associated with the number of clinical pharmacy recommendations: findings from an observational study in geriatric inpatients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31642397 |keywords=* Clinical pharmacy * geriatrics * inpatients * polypharmacy * risk stratification |full-text-url=https://sci-hub.do/10.1080/17843286.2019.1683128 }} {{medline-entry |title=Protection against oxidative stress and anti-aging effect in Drosophila of royal jelly-collagen peptide. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31622731 |mesh-terms=* Aging * Amino Acids * Animals * Body Weight * Collagen * Drosophila * Fatty Acids * Feeding Behavior * Hydrogen Peroxide * Longevity * Molecular Weight * Oxidative Stress * Paraquat |keywords=* Anti-aging * Antioxidant activity * Collagen * Drosophila * Royal jelly |full-text-url=https://sci-hub.do/10.1016/j.fct.2019.110881 }} ==CPM== {{medline-entry |title=Test-Retest Instability of Temporal Summation and Conditioned Pain Modulation Measures in Older Adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33083842 |keywords=* Aging * Anxiety * Conditioned Pain Modulation * Pain Catastrophizing * Reliability * Temporal Summation of Pain |full-text-url=https://sci-hub.do/10.1093/pm/pnaa288 }} {{medline-entry |title=Age does not affect sex effect of conditioned pain modulation of pressure and thermal pain across 2 conditioning stimuli. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32072094 |keywords=* Aging * CPM duration * Conditioned pain modulation * Conditioning stimulus * Sex differences * Test stimulus |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004505 }} {{medline-entry |title=The Decline of Endogenous Pain Modulation With Aging: A Meta-Analysis of Temporal Summation and Conditioned Pain Modulation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31562994 |keywords=* Aging * conditioned pain modulation * meta-analysis * pain modulation * temporal summation |full-text-url=https://sci-hub.do/10.1016/j.jpain.2019.09.005 }} ==CPNE1== {{medline-entry |title=Prevalent intron retention fine-tunes gene expression and contributes to cellular senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33274830 |keywords=* CPNE1 * U2AF1 * intron retention * senescence * splicing factor |full-text-url=https://sci-hub.do/10.1111/acel.13276 }} ==CPT1A== {{medline-entry |title=Alteration of fatty acid oxidation by increased [[CPT1A]] on replicative senescence of placenta-derived mesenchymal stem cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31900237 |keywords=* CPT1A * Fatty acid * Mitochondria * Placenta-derived mesenchymal stem cell * Senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941254 }} ==CPT1C== {{medline-entry |title=Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC-5 fibroblasts via regulating lipid accumulation and mitochondrial function. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32632982 |keywords=* MRC-5 fibroblasts * carnitine palmitoyltransferase 1C (CPT1C) * cellular senescence * lipidomics * mitochondrial function |full-text-url=https://sci-hub.do/10.1002/jcp.29906 }} {{medline-entry |title=Carnitine palmitoyltransferase 1C contributes to progressive cellular senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32289751 |keywords=* carnitine palmitoyltransferase 1C * metabolic reprogramming * mitochondria * senescence * stable transfection |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202531 }} ==CPT2== {{medline-entry |title=The phytochemical epigallocatechin gallate prolongs the lifespan by improving lipid metabolism, reducing inflammation and oxidative stress in high-fat diet-fed obese rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32729662 |keywords=* EGCG * free fatty acid * high-fat dietary * lifespan * proteomics * transcriptome |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511879 }} ==CR1== {{medline-entry |title=Single Nucleotide Polymorphisms in Alzheimer's Disease Risk Genes Are Associated with Intrinsic Connectivity in Middle Age. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32986668 |keywords=* Aging * Alzheimer’s disease * middle aged * neuroimaging * single nucleotide polymorphism |full-text-url=https://sci-hub.do/10.3233/JAD-200444 }} {{medline-entry |title=The whale shark genome reveals how genomic and physiological properties scale with body size. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32753383 |mesh-terms=* Adaptation, Physiological * Animals * Base Sequence * Body Size * Genome * Genomics * Longevity * Sharks * Temperature |keywords=* body size * lifespan * metabolic rate * neural genes * whale shark |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456109 }} ==CRABP2== {{medline-entry |title=Preconception resveratrol intake against infertility: Friend or foe? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32273814 |keywords=* aging * assisted reproductive technology * infertility * resveratrol * sirtuin |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138940 }} ==CRBN== {{medline-entry |title=Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32332723 |mesh-terms=* Adaptor Proteins, Signal Transducing * Aging * Aniline Compounds * Animals * Blood Platelets * Cell Line * Cellular Senescence * Female * Humans * Male * Mice * Mice, Transgenic * Models, Animal * Primary Cell Culture * Proteolysis * Sulfonamides * Ubiquitin-Protein Ligases * bcl-X Protein |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181703 }} ==CRP== {{medline-entry |title=Omega-3 supplementation improves isometric strength but not muscle anabolic and catabolic signaling in response to resistance exercise in healthy older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33284965 |keywords=* Muscle wasting * aging * anabolic resistance * inflammation * resistance training * sarcopenia |full-text-url=https://sci-hub.do/10.1093/gerona/glaa309 }} {{medline-entry |title=Circulating angiopoietin-like protein 2 levels and arterial stiffness in patients receiving maintenance hemodialysis: A cross-sectional study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33197687 |keywords=* Angiopoietin-like protein (ANGPTL) 2 * Cardio-ankle vascular index (CAVI) * Chronic inflammation * Hemodialysis * Senescence |full-text-url=https://sci-hub.do/10.1016/j.atherosclerosis.2020.10.890 }} {{medline-entry |title=Cardiovascular rehabilitation in patients aged 70-year-old or older: benefits on functional capacity, physical activity and metabolic profile in younger [i]vs[/i]. older patients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33117418 |keywords=* Aging * Cardiovascular prevention * Exercise-based cardiac rehabilitation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568038 }} {{medline-entry |title=rRT-PCR Results of a Covid-19 Diagnosed Geriatric Patient. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33103060 |keywords=* COVID-19 * False negative reactions * Geriatrics * Mass screening * Reverse transcriptase polymerase chain reaction * SARS-CoV-2 * Tomography |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567648 }} {{medline-entry |title=The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33080140 |keywords=* aging * growth differentiation factor 15 * idiopathic pulmonary fibrosis * interstitial lung abnormalities * mortality |full-text-url=https://sci-hub.do/10.1164/rccm.202007-2993OC }} {{medline-entry |title=A Novel Fortified Dairy Product and Sarcopenia Measures in Sarcopenic Older Adults: A Double-Blind Randomized Controlled Trial. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33067129 |keywords=* Functional food * aging * beta-hydroxy beta-methylbutyrate * muscle strength * sarcopenia * vitamin D |full-text-url=https://sci-hub.do/10.1016/j.jamda.2020.08.035 }} {{medline-entry |title=Age-Related Colonic Mucosal Microbiome Community Shifts in Monkeys. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33021628 |keywords=* Aging * Microbial co-occurrences * Mucosal microbiome * Systemic inflammation |full-text-url=https://sci-hub.do/10.1093/gerona/glaa256 }} {{medline-entry |title=The relationship between frailty and serum alpha klotho levels in geriatric patients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32905907 |keywords=* Aging * Biomarkers * Frailty syndrome * Geriatric syndrome * Sarcopenia |full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104225 }} {{medline-entry |title=ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32872320 |keywords=* ZMPSTE24 * aging * inflammation * lamin A/C * progerin |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563344 }} {{medline-entry |title=Cultural and life style practices associated with low inflammatory physiology in Japanese adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32805392 |keywords=* Aging * Bathing * C-reactive protein * Diet * Inflammation * Interleukin-6 * Japan * Tea |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544652 }} {{medline-entry |title=Moderate- to high intensity aerobic and resistance exercise reduces peripheral blood regulatory cell populations in older adults with rheumatoid arthritis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32467712 |keywords=* Aging * Breg cells * Exercise * IL-10 * Rheumatoid arthritis * T cells * Treg cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229606 }} {{medline-entry |title=PTSD and the klotho longevity gene: Evaluation of longitudinal effects on inflammation via DNA methylation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32438247 |keywords=* Accelerated aging * Inflammation * Klotho * Methylation * PTSD |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293549 }} {{medline-entry |title=Bereavement is associated with reduced systemic inflammation: C-reactive protein before and after widowhood. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32283288 |keywords=* Aging * Bereavement * C-reactive protein * Health * Inflammation * Widowhood |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415735 }} {{medline-entry |title=The Impact of Age on the Prevalence of Sarcopenic Obesity in Bariatric Surgery Candidates. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32249368 |keywords=* Aging * Bariatric surgery * Elderly * Obesity * Sarcopenia |full-text-url=https://sci-hub.do/10.1007/s11695-019-04198-4 }} {{medline-entry |title=Intake of dietary advanced glycation end products influences inflammatory markers, immune phenotypes, and antiradical capacity of healthy elderly in a little-studied population. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32148813 |keywords=* CRP * advanced glycationed end products * aging * dAGE * immunity * inflammation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020308 }} {{medline-entry |title=Intentional Switching Between Bimanual Coordination Patterns in Older Adults: Is It Mediated by Inhibition Processes? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32132919 |keywords=* Stroop task * aging * bimanual coordination * inhibition * mediation analysis * switching |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041435 }} {{medline-entry |title=Shorter Telomere Length in Peripheral Blood Leukocytes Is Associated with Post-Traumatic Chronic Osteomyelitis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32125944 |keywords=* aging * post-traumatic chronic osteomyelitis * telomere |full-text-url=https://sci-hub.do/10.1089/sur.2019.326 }} {{medline-entry |title=Risk Factors of Progression to Frailty: Findings from the Singapore Longitudinal Ageing Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31886815 |mesh-terms=* Aged * Aged, 80 and over * Aging * Disease Progression * Female * Frail Elderly * Frailty * Geriatric Assessment * Humans * Independent Living * Longitudinal Studies * Male * Nutrition Assessment * Nutritional Status * Physical Examination * Risk Factors * Singapore * Socioeconomic Factors |keywords=* Frailty * longitudinal * risk factors * transition |full-text-url=https://sci-hub.do/10.1007/s12603-019-1277-8 }} {{medline-entry |title=Physical Function and Strength in Relation to Inflammation in Older Adults with Obesity and Increased Cardiometabolic Risk. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31781724 |mesh-terms=* Aged * Aging * Cardiovascular Diseases * Female * Humans * Inflammation * Male * Muscle Strength * Obesity * Physical Exertion |keywords=* Inflammation * cardiovascular disease risk factors * obesity * physical activity * physical function |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996491 }} {{medline-entry |title=Key diagnostic characteristics of fever of unknown origin in Japanese patients: a prospective multicentre study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31748308 |mesh-terms=* Adult * Aged * Aged, 80 and over * Female * Fever of Unknown Origin * Humans * Japan * Male * Middle Aged * Prospective Studies * Young Adult |keywords=* Japan * aging population * elderly * erythrocyte sedimentation rate * fever of unknown origin * prospective studies |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886908 }} {{medline-entry |title=Decrease in Serum Vitamin D Level of Older Patients with Fatigue. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31635199 |mesh-terms=* Aged * Cohort Studies * Fatigue * Female * Humans * Male * Middle Aged * Vitamin D * Vitamin D Deficiency |keywords=* aging * mental fatigue * older * physical fatigue * sex differences * vitamin D |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836014 }} {{medline-entry |title=The Association between Frailty Indicators and Blood-Based Biomarkers in Early-Old Community Dwellers of Thailand. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31533354 |mesh-terms=* Aged * Aged, 80 and over * Biomarkers * C-Reactive Protein * CD4-CD8 Ratio * Cross-Sectional Studies * Female * Frail Elderly * Frailty * Humans * Independent Living * Interleukin-6 * Male * Middle Aged * Thailand |keywords=* C-reactive protein * Thailand * aging * cross-sectional study * frailty * frailty biomarkers * fried’s phenotypes * interleukin-6 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765843 }} {{medline-entry |title=Associations of C-reactive protein and homocysteine concentrations with the impairment of intrinsic capacity domains over a 5-year follow-up among community-dwelling older adults at risk of cognitive decline (MAPT Study). |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31493520 |mesh-terms=* Activities of Daily Living * Aged * Biomarkers * Body Mass Index * C-Reactive Protein * Cognitive Dysfunction * Depression * Female * Follow-Up Studies * Geriatric Assessment * Hand Strength * Homocysteine * Humans * Independent Living * Inflammation * Male * Mobility Limitation * Neuropsychological Tests * Prospective Studies * Risk Factors * Time Factors |keywords=* Aging * C-reactive protein * Homocysteine * Inflammation * Intrinsic capacity * Older adults |full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110716 }} {{medline-entry |title=Longitudinal analysis of loneliness and inflammation at older ages: English longitudinal study of ageing. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31494341 |mesh-terms=* Age Factors * Aged * Aged, 80 and over * Aging * C-Reactive Protein * England * Female * Ferritins * Fibrinogen * Humans * Inflammation * Loneliness * Longitudinal Studies * Male * Middle Aged |keywords=* C-reactive protein * Ferritin * Fibrinogen * Inflammation * Loneliness |full-text-url=https://sci-hub.do/10.1016/j.psyneuen.2019.104421 }} {{medline-entry |title=The cortisol burden in elderly subjects with metabolic syndrome and its association with low-grade inflammation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31471891 |mesh-terms=* Aged * Aged, 80 and over * Echocardiography * Female * Humans * Hydrocortisone * Inflammation * Male * Metabolic Syndrome |keywords=* Aging * Cortisol * Inflammation * Metabolic syndrome |full-text-url=https://sci-hub.do/10.1007/s40520-019-01322-3 }} {{medline-entry |title=Recurrent circadian fasting (RCF) improves blood pressure, biomarkers of cardiometabolic risk and regulates inflammation in men. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31426866 |mesh-terms=* Adult * Biomarkers * Blood Pressure * C-Reactive Protein * Cardiovascular Diseases * Circadian Rhythm * Diet * Energy Intake * Fasting * Heart Rate * Humans * Inflammation * Male * Metabolic Diseases * Middle Aged * Nutritional Physiological Phenomena * Regression Analysis * Risk Factors * Young Adult |keywords=* Aging * Health benefits * Inflammation * Recurrent fasting |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700786 }} {{medline-entry |title=Characteristics of patients with rheumatoid arthritis undergoing primary total joint replacement: A 14-year trend analysis (2004-2017). |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31393198 |mesh-terms=* Adult * Aged * Antirheumatic Agents * Arthritis, Rheumatoid * Arthroplasty, Replacement * Arthroplasty, Replacement, Knee * Biological Products * Drug Utilization * Female * Humans * Japan * Male * Middle Aged * Postoperative Complications |keywords=* C-reactive protein * Rheumatoid arthritis * aging * arthroplasty * drug therapy |full-text-url=https://sci-hub.do/10.1080/14397595.2019.1649111 }} ==CS== {{medline-entry |title=Acute effect of bodyweight-based strength training on blood pressure of hypertensive older adults: A randomized crossover clinical trial. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33198514 |keywords=* Exercise * aging * hypertension * hypotension * resistance training |full-text-url=https://sci-hub.do/10.1080/10641963.2020.1847130 }} {{medline-entry |title=Particle growth with photochemical age from new particle formation to haze in the winter of Beijing, China. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33207435 |keywords=* Condensation sink * Haze * New particle formation * Photochemical aging * Pollution evolution |full-text-url=https://sci-hub.do/10.1016/j.scitotenv.2020.142207 }} {{medline-entry |title=Effect of aging on stabilization of Cd and Ni by biochars and enzyme activities in a historically contaminated alkaline agricultural soil simulated with wet-dry and freeze-thaw cycling. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143976 |keywords=* Accelerated aging * Biochar * Cadmium * Enzyme activity * Heavy metal stabilization * Soil remediation |full-text-url=https://sci-hub.do/10.1016/j.envpol.2020.115846 }} {{medline-entry |title=Cockayne syndrome proteins [[CS]]A and [[CS]]B maintain mitochondrial homeostasis through NAD signaling. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33166073 |keywords=* AMPK * Cockayne syndrome * NAD+ * accelerated ageing * aging * mitochondrial maintenance * mitophagy |full-text-url=https://sci-hub.do/10.1111/acel.13268 }} {{medline-entry |title=Vision Impairment and Participation in Cognitively Stimulating Activities: The Health ABC Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32710546 |keywords=* Cognition * Cognitive Aging * Sensory * Vision loss |full-text-url=https://sci-hub.do/10.1093/gerona/glaa184 }} {{medline-entry |title=Suspension training vs. traditional resistance training: effects on muscle mass, strength and functional performance in older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32700098 |keywords=* Aging * Functionality * Instability resistance training * Muscle hypertrophy * TRX training |full-text-url=https://sci-hub.do/10.1007/s00421-020-04446-x }} {{medline-entry |title=Generational Differences in the 10-year Incidence of Impaired Contrast Sensitivity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32693658 |keywords=* Aging * Birth Cohort Effect * Contrast Sensitivity * Epidemiology * Visual Function |full-text-url=https://sci-hub.do/10.1080/09286586.2020.1791909 }} {{medline-entry |title=Inducible aging in Hydra oligactis implicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32578072 |keywords=* Aging * Cold-sensitive * DNA repair * Gametogenesis * Hydra oligactis * Transcriptome |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394996 }} {{medline-entry |title=Noradrenergic Responsiveness Supports Selective Attention across the Adult Lifespan. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32317388 |mesh-terms=* Adult * Aged * Aging * Attention * Brain Waves * Cortical Synchronization * Humans * Male * Norepinephrine * Reflex, Pupillary |keywords=* cognitive aging * locus coeruleus * noradrenaline * norepinephrine * rhythmic neural activity * selective attention |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252473 }} {{medline-entry |title=Cellular senescence: from anti-cancer weapon to anti-aging target. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32060861 |mesh-terms=* Aging * Animals * Antineoplastic Agents * Breast Neoplasms * Cell Proliferation * Cell Transformation, Neoplastic * Cellular Senescence * Cyclin-Dependent Kinases * Drug Discovery * Female * Humans * Piperazines * Protein Kinase Inhibitors * Pyridines |keywords=* cancer * cellular senescence * healthy aging * pro-senescence cancer therapy * senolytic therapies |full-text-url=https://sci-hub.do/10.1007/s11427-019-1629-6 }} {{medline-entry |title=Extra-mitochondrial citrate synthase initiates calcium oscillation and suppresses age-dependent sperm dysfunction. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31857692 |mesh-terms=* Aging * Animals * Calcium Signaling * Citrate (si)-Synthase * Citric Acid Cycle * Female * Infertility, Male * Male * Metabolome * Mice * Ovum * Spermatozoa |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096335 }} {{medline-entry |title=Pathogenesis of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31737341 |keywords=* Airway inflammation * autophagy * cellular senescence * chronic obstructive pulmonary disease (COPD) * necroptosis * oxidative stress |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831915 }} {{medline-entry |title=Possible Role of Amyloid Cross-Seeding in Evolvability and Neurodegenerative Disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31524179 |mesh-terms=* Aging * Amyloidogenic Proteins * Animals * Biological Evolution * Brain * Female * Humans * Inheritance Patterns * Models, Neurological * Neurodegenerative Diseases * Pregnancy * Stress, Physiological |keywords=* Alzheimer’s disease * Parkinson’s disease * amyloid cascade hypothesis * amyloidogenic proteins * antimicrobial protection model * cross-seeding * evolvability hypothesis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839461 }} {{medline-entry |title=Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting IGF1/Akt1 signaling in mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31428695 |mesh-terms=* Alveolar Epithelial Cells * Animals * Cell Proliferation * Cellular Senescence * Cyclin-Dependent Kinase Inhibitor p16 * Cytokines * Emphysema * Insulin-Like Growth Factor I * Lung * Mice, Inbred C57BL * Models, Biological * Promoter Regions, Genetic * Proto-Oncogene Proteins c-akt * Pulmonary Disease, Chronic Obstructive * RNA, Messenger * Signal Transduction * Smoking |keywords=* Molecular biology * Senescence * Stem cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689060 }} ==CSF1R== {{medline-entry |title=[[CSF1R]] inhibitor PLX5622 and environmental enrichment additively improve metabolic outcomes in middle-aged female mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32007953 |keywords=* CSF1R * adipose * aging * environmental enrichment * microglia |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041757 }} {{medline-entry |title=Modulation of Microglia by Voluntary Exercise or [[CSF1R]] Inhibition Prevents Age-Related Loss of Functional Motor Units. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31693894 |mesh-terms=* Aging * Animals * Cell Line * Databases, Genetic * Humans * Induced Pluripotent Stem Cells * Macrophages * Male * Mice * Mice, Inbred C57BL * Microglia * Motor Neurons * Muscle, Skeletal * Neuromuscular Junction * Neuronal Plasticity * Physical Conditioning, Animal * RNA-Seq * Receptors, Granulocyte-Macrophage Colony-Stimulating Factor * Spinal Cord |keywords=* CSF1R inhibition * aging * exercise * innervation * microglia * motor unit * neuroinflammation * neuromuscular junction * neuromuscular system * spinal cord |full-text-url=https://sci-hub.do/10.1016/j.celrep.2019.10.003 }} ==CTCF== {{medline-entry |title=New targeted approaches for epigenetic age predictions. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32580727 |keywords=* Aging * Amplicon sequencing * Blood * Buccal swabs * CTCF * DNA methylation * Droplet digital PCR * Epigenetic * Human |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315536 }} ==CTH== {{medline-entry |title=Anterior Cingulate Structure and Perfusion is Associated with Cerebrospinal Fluid Tau among Cognitively Normal Older Adult APOEɛ4 Carriers. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31743999 |keywords=* APOE * Aging * Alzheimer’s disease * cerebral blood flow * cognition * cognitive decline * grey matter * magnetic resonance imaging * tau proteins |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310575 }} ==CTLA4== {{medline-entry |title=Horticultural Therapy Reduces Biomarkers of Immunosenescence and Inflammaging in Community-Dwelling Older Adults: A Feasibility Pilot Randomized Controlled Trial. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33070170 |keywords=* CTLA-4 * Geroscience * IL-6 * Immunosenescence * Inflammaging |full-text-url=https://sci-hub.do/10.1093/gerona/glaa271 }} ==CTRL== {{medline-entry |title=Aging reduces the maximal level of peripheral fatigue tolerable and impairs exercise capacity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32966120 |keywords=* aging * critical torque * exercise performance * group III/IV muscle afferents * neuromuscular fatigue |full-text-url=https://sci-hub.do/10.1152/ajpregu.00151.2020 }} {{medline-entry |title=miR-146a Plasma Levels Are Not Altered in Alzheimer's Disease but Correlate With Age and Illness Severity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32009940 |keywords=* Alzheimer’s disease * aging * blood * miR-146a * microRNA * plasma |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978630 }} {{medline-entry |title=Centrally-mediated regulation of peripheral fatigue during knee extensor exercise and consequences on the force-duration relationship in older men. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31397211 |keywords=* Aging * critical torque * group III/IV muscle afferents |full-text-url=https://sci-hub.do/10.1080/17461391.2019.1655099 }} ==CTSA== {{medline-entry |title=A [[CTSA]]-based consultation service to advance research on special and underserved populations. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33244406 |keywords=* faculty development * geriatrics * grant review * grant studio * pediatrics * peer review * research consultation service * special populations * underrepresented minorities |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681147 }} ==CTSB== {{medline-entry |title=Myocardial cathepsin D is downregulated in sudden cardiac death. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32176724 |mesh-terms=* Adult * Aged * Aged, 80 and over * Aging * Cathepsin D * Death, Sudden, Cardiac * Down-Regulation * Female * Humans * Male * Middle Aged * Myocardium * Substrate Specificity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075574 }} ==CX3CL1== {{medline-entry |title=Two forms of [[CX3CL1]] display differential activity and rescue cognitive deficits in [[CX3CL1]] knockout mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32410624 |keywords=* Aging * CX3CL1 * Cognition * Fractalkine * Long-term potentiation * Microglia * Neurodegeneration * Neurogenesis * Neuroinflammation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227354 }} ==CX3CR1== {{medline-entry |title=Monocytes present age-related changes in phospholipid concentration and decreased energy metabolism. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32107839 |keywords=* DNA methylation * aging * glucose metabolism * monocytes * phosphatidylcholines * transcriptome |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189998 }} {{medline-entry |title=Muscle Injury Induces Postoperative Cognitive Dysfunction. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32066806 |mesh-terms=* Aging * Animals * Brain * Brain-Derived Neurotrophic Factor * CX3C Chemokine Receptor 1 * Cytokines * Disease Models, Animal * Hippocampus * Humans * Male * Mice * Microglia * Muscle, Skeletal * Nerve Growth Factor * Postoperative Cognitive Complications * Postoperative Complications |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026159 }} ==CXCL1== {{medline-entry |title=Contusion spinal cord injury upregulates p53 protein expression in rat soleus muscle at multiple timepoints but not key senescence cytokines. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32026570 |keywords=* SASP * cytokines * inflammation * paralysis * senescence * spinal cord injury |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002538 }} {{medline-entry |title=Systemic Inflammation and the Increased Risk of Inflamm-Aging and Age-Associated Diseases in People Living With HIV on Long Term Suppressive Antiretroviral Therapy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31507593 |mesh-terms=* Adult * Aging * Anti-HIV Agents * Antiretroviral Therapy, Highly Active * Biomarkers * CD4 Lymphocyte Count * Computational Biology * Cross-Sectional Studies * Disease Susceptibility * Duration of Therapy * Female * HIV Infections * Humans * Inflammation * Male * Metabolome * Metabolomics * Middle Aged * Proteomics * Telomere Homeostasis * Viral Load |keywords=* HIV * India * LMIC (lower middle income country) * inflammation markers * long term antiretroviral therapy |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718454 }} ==CXCL10== {{medline-entry |title=Age-related decline of interferon-gamma responses in macrophage impairs satellite cell proliferation and regeneration. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32725722 |keywords=* Aging * CXCL10 * IFN-γ * Macrophage * Muscle regeneration * Single-cell RNA sequence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7567146 }} ==CXCL11== {{medline-entry |title=Endothelial cells under therapy-induced senescence secrete [[CXCL11]], which increases aggressiveness of breast cancer cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32659248 |keywords=* CXCL11 * Endothelial cells * Therapy-induced senescence * Tumor microenvironment |full-text-url=https://sci-hub.do/10.1016/j.canlet.2020.06.019 }} ==CXCL12== {{medline-entry |title=Co-option of Neutrophil Fates by Tissue Environments. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33098771 |keywords=* angiogenesis * immune heterogeneity * immune niche * innate immunity * neutrophil lifespan * neutrophils * single-cell analysis * tissue-resident cells |full-text-url=https://sci-hub.do/10.1016/j.cell.2020.10.003 }} {{medline-entry |title=Heme oxygenase-1 deficiency triggers exhaustion of hematopoietic stem cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31885181 |keywords=* aging * bone marrow * cxcl12-abudant reticular cells * endothelial cells * niche |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001511 }} {{medline-entry |title=Global Transcriptomic Profiling of the Bone Marrow Stromal Microenvironment during Postnatal Development, Aging, and Inflammation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31801092 |mesh-terms=* Aging * Animals * Bone Marrow * Bone Marrow Cells * Cell Differentiation * Cells, Cultured * Cellular Microenvironment * Chemokine CXCL12 * Embryonic Development * Endothelial Cells * Gene Expression Profiling * Hematopoiesis * Hematopoietic Stem Cells * Inflammation * Male * Mesenchymal Stem Cells * Mice * Mice, Inbred C57BL * Stem Cell Niche * Transcriptome |keywords=* aging * bone marrow microenvironment * hematopoietic stem cells * inflammation * niches * stromal cells * transcriptomics |full-text-url=https://sci-hub.do/10.1016/j.celrep.2019.11.004 }} ==CXCL13== {{medline-entry |title=RNA-seq data from C-X-C chemokine receptor type 5 (CXCR5) gene knockout aged mice with retinal degeneration phenotype. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32642521 |keywords=* CXCR5 * FastQC * RNA-Seq * aging * choroid * mice * retina * retinal degeneration |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334305 }} ==CXCL14== {{medline-entry |title=Identification of genes associated with endometrial cell aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33258951 |keywords=* CXCL12 * CXCL14 * IL17RB * endometrial cell aging * infertility * quantitative immunohistochemistry |full-text-url=https://sci-hub.do/10.1093/molehr/gaaa078 }} ==CXCL8== {{medline-entry |title=Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33041998 |keywords=* Alzheimer's disease * endothelial senescence * gene expression * neurofibrillary tangles * plasma biomarkers * tau pathology * vascular dysfunction |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525127 }} ==CXCL9== {{medline-entry |title=[[CXCL9]] and CXCL10 display an age-dependent profile in Chagas patients: a cohort study of aging in Bambui, Brazil. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32393333 |mesh-terms=* Aged * Aged, 80 and over * Aging * Biomarkers * Brazil * Chagas Disease * Chemokine CXCL10 * Chemokine CXCL9 * Cohort Studies * Electrocardiography * Female * Humans * Male * Middle Aged * Trypanosoma cruzi |keywords=* Chagas disease * Chemokines * Cohort * Cytokines * Immune biomarkers |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216412 }} ==CXCR2== {{medline-entry |title=CXCL5-[[CXCR2]] signaling is a senescence-associated secretory phenotype in preimplantation embryos. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32959976 |keywords=* CXCL5 * CXCR2 * SASP * aging * infertility * preimplantation embryo |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576282 }} {{medline-entry |title=Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32850866 |keywords=* ageing * diabetes * senescence * senolytics * wound healing |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431694 }} ==CXCR3== {{medline-entry |title=Senescent hepatocytes enhance natural killer cell activity via the CXCL-10/[[CXCR3]] axis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31616512 |keywords=* chemokine * hepatocyte * natural killer cell * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781833 }} ==CXCR4== {{medline-entry |title=Aging-Related Reduced Expression of [[CXCR4]] on Bone Marrow Mesenchymal Stromal Cells Contributes to Hematopoietic Stem and Progenitor Cell Defects. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32418119 |keywords=* Aging * CXCR4 and ROS * HSPC * MSC |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395885 }} {{medline-entry |title=Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type 2 diabetic mice through induction of the SDF-1/[[CXCR4]] signalling pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32384208 |keywords=* BPIFB4 * Cardiomyopathy * Diabetes * Gene therapy * Longevity |full-text-url=https://sci-hub.do/10.1002/ejhf.1840 }} {{medline-entry |title=Stromal Cell-Derived Factor 1 Protects Brain Vascular Endothelial Cells from Radiation-Induced Brain Damage. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31658727 |mesh-terms=* Animals * Blood Vessels * Brain * Cell Line * Cellular Senescence * Chemokine CXCL12 * Cranial Irradiation * Disease Models, Animal * Down-Regulation * Endothelial Cells * Female * Gene Expression Regulation * Humans * Lipopeptides * Mice * Receptors, CXCR4 * Signal Transduction |keywords=* CXCR4 * SDF-1 * brain disorder * endothelial dysfunction * ionizing radiation * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830118 }} ==CYP11B1== {{medline-entry |title=Intratumoral heterogeneity of the tumor cells based on in situ cortisol excess in cortisol-producing adenomas; ∼An association among morphometry, genotype and cellular senescence∼. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33002589 |keywords=* CYP11B1 * CYP17A * Cellular senescence * Compact and clear cells * Cortisol-producing adenoma * PRKACA |full-text-url=https://sci-hub.do/10.1016/j.jsbmb.2020.105764 }} ==CYP1A1== {{medline-entry |title=Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31522824 |mesh-terms=* Adult * Aged * Aged, 80 and over * Asian Continental Ancestry Group * Cheek * Cohort Studies * Cytochrome P-450 CYP1A1 * European Continental Ancestry Group * Female * Genome-Wide Association Study * Humans * Middle Aged * Polymorphism, Single Nucleotide * Risk Factors * Skin Aging * Skin Pigmentation |keywords=* Candidate SNPs * Chinese Han females * GWAS * Skin aging |full-text-url=https://sci-hub.do/10.1016/j.jdermsci.2019.08.010 }} ==CYP26B1== {{medline-entry |title=Increased Retinoic Acid Catabolism in Olfactory Sensory Neurons Activates Dormant Tissue-Specific Stem Cells and Accelerates Age-Related Metaplasia. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32385093 |mesh-terms=* Aging * Animals * Female * Isotretinoin * Male * Metaplasia * Mice * Neural Stem Cells * Neurogenesis * Olfactory Mucosa * Olfactory Receptor Neurons * Retinoic Acid 4-Hydroxylase |keywords=* aging * inositol-1,4,5-triphosphate * metaplasia * olfactory epithelium * retinoic acid * stem cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244205 }} ==CYP2C19== {{medline-entry |title=Physiologically Based Pharmacokinetic Approach Can Successfully Predict Pharmacokinetics of Citalopram in Different Patient Populations. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31750550 |keywords=* citalopram * genetic polymorphism * geriatrics * physiologically based pharmacokinetic modeling |full-text-url=https://sci-hub.do/10.1002/jcph.1541 }} {{medline-entry |title=Longitudinal exposure of English primary care patients to pharmacogenomic drugs: An analysis to inform design of pre-emptive pharmacogenomic testing. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31454087 |mesh-terms=* Aged * Aged, 80 and over * Aging * Cytochrome P-450 CYP2C19 * Cytochrome P-450 CYP2D6 * Drug Prescriptions * Female * Humans * Liver-Specific Organic Anion Transporter 1 * Longitudinal Studies * Male * Middle Aged * Pharmaceutical Preparations * Pharmacogenomic Testing * Precision Medicine * Primary Health Care * United Kingdom |keywords=* clinical pharmacology * general practice * pharmacogenomics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955399 }} ==CYP2E1== {{medline-entry |title=DNA methylation and histone acetylation changes to cytochrome P450 2E1 regulation in normal aging and impact on rates of drug metabolism in the liver. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32221779 |keywords=* Aging * Cyp2e1 * DNA methylation * Drug metabolism * Histone acetylation * Pharmacokinetics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287002 }} ==CYP7A1== {{medline-entry |title=Age-associated changes of cytochrome P450 and related phase-2 gene/proteins in livers of rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31396457 |keywords=* Aging * Cytochrome P450’s * Nuclear receptors * Ontogeny * Rat liver * mRNA/protein expression |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681801 }} ==DBI== {{medline-entry |title=Quantifying cumulative anticholinergic and sedative drug load among US Medicare Beneficiaries. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33000867 |keywords=* aging * cholinergic antagonists * drug burden index * drug utilization * hypnotics and sedatives * inappropriate prescribing * pharmacoepidemiology |full-text-url=https://sci-hub.do/10.1002/pds.5144 }} {{medline-entry |title=Drug Burden Index and Cognitive and Physical Function in Aged Care Residents: A Longitudinal Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32736845 |keywords=* Cognitive function * anti-muscarinics * benzodiazepines * geriatrics * longitudinal * mobility impairment * physical function * polypharmacy |full-text-url=https://sci-hub.do/10.1016/j.jamda.2020.05.037 }} {{medline-entry |title=Using the Drug Burden Index to identify older adults at highest risk for medication-related falls. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32532276 |keywords=* Accidental falls * Aging * Health services * Medication * Medication therapy management |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291506 }} {{medline-entry |title=Impact of STEADI-Rx: A Community Pharmacy-Based Fall Prevention Intervention. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32315461 |keywords=* aging * community pharmacy * falls * health services * medication |full-text-url=https://sci-hub.do/10.1111/jgs.16459 }} ==DBP== {{medline-entry |title=Do baseline blood pressure and type of exercise influence level of reduction induced by training in hypertensive older adults? A meta-analysis of controlled trials. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32795629 |keywords=* Aged * Aging * Exercise * Exercise therapy * High blood pressure * Hypertension * Resistance training |full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111052 }} {{medline-entry |title=Attenuated aortic blood pressure responses to metaboreflex activation in older adults with dynapenia. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32502600 |keywords=* Aging * Diastolic pressure * Handgrip strength * Post-exercise muscle ischemia * Walking performance |full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110984 }} {{medline-entry |title=The Effect of Blood Pressure on Cognitive Performance. An 8-Year Follow-Up of the Tromsø Study, Comprising People Aged 45-74 Years. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32373010 |keywords=* aging * blood pressure * cognitive performance * dementia * sex differences |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186429 }} {{medline-entry |title=Low Diastolic Blood Pressure and Cognitive Decline in Korean Elderly People: The Korean Longitudinal Study on Cognitive Aging and Dementia. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31995969 |keywords=* Cognition * Diastolic blood pressure * Senility |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992855 }} {{medline-entry |title=Diastolic Blood Pressure Is Associated With Regional White Matter Lesion Load: The Northern Manhattan Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31910743 |mesh-terms=* Aged * Arterial Pressure * Blood Pressure * Brain * Cohort Studies * Diastole * Female * Frontal Lobe * Humans * Hypertension * Linear Models * Magnetic Resonance Imaging * Male * Middle Aged * Organ Size * Parietal Lobe * Prospective Studies * Systole * Temporal Lobe * White Matter |keywords=* American Heart Association * blood pressure * cerebrovascular disease * cognitive aging * white matter |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219602 }} {{medline-entry |title=Orthostatic Hypotension and Novel Blood Pressure Associated Gene Variants in Older Adults: Data From the TILDA Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31821404 |keywords=* Aging * Blood pressure * Cardiovascular * Genetics * Single-nucleotide polymorphism |full-text-url=https://sci-hub.do/10.1093/gerona/glz286 }} {{medline-entry |title=Blood pressure and hypertension prevalence among oldest-old in China for 16 year: based on CLHLS. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31500574 |mesh-terms=* Aged, 80 and over * Blood Pressure * Blood Pressure Determination * China * Female * Health Surveys * Humans * Hypertension * Longevity * Longitudinal Studies * Male * Prevalence |keywords=* Blood pressure * Epidemiology * Hypertension * Oldest-old * Prevalence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734230 }} {{medline-entry |title=The age-related blood pressure trajectories from young-old adults to centenarians: A cohort study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31443986 |mesh-terms=* Age Factors * Aged * Aged, 80 and over * Aging * Blood Pressure * Cohort Studies * Female * Humans * Male * Middle Aged |keywords=* Antihypertensive therapy * Birth cohort effect * Blood pressure * Cohort study * Heart disease * Survival |full-text-url=https://sci-hub.do/10.1016/j.ijcard.2019.08.011 }} ==DCC== {{medline-entry |title=X Chromosome Domain Architecture Regulates Caenorhabditis elegans Lifespan but Not Dosage Compensation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31495695 |mesh-terms=* Adenosine Triphosphatases * Animals * Caenorhabditis elegans * Caenorhabditis elegans Proteins * DNA-Binding Proteins * Dosage Compensation, Genetic * Gene Expression Regulation * Longevity * Multiprotein Complexes * X Chromosome |keywords=* X chromosome dosage compensation * aging * condensin * gene expression * higher-order chromosome structure * lifespan * proteotoxic stress * topologically associating domains |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6810858 }} ==DCN== {{medline-entry |title=Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33257596 |keywords=* IGF-I * aging * bone marrow mesenchymal stem cell * osteoporosis * small leucine-rich proteoglycan |full-text-url=https://sci-hub.do/10.18632/aging.202166 }} ==DCX== {{medline-entry |title=GSK-3β activation accelerates early-stage consumption of Hippocampal Neurogenesis in senescent mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32863953 |keywords=* Adult hippocampal neurogenesis * Glycogen synthase kinase-3β * Senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449917 }} {{medline-entry |title=Doublecortin and IGF-1R protein levels are reduced in spite of unchanged DNA methylation in the hippocampus of aged rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32236698 |keywords=* Aging * DNA methylation * Doublecortin * Hippocampus * IGF-1R * mGluR5 |full-text-url=https://sci-hub.do/10.1007/s00726-020-02834-3 }} ==DDB1== {{medline-entry |title=DCAF1 regulates Treg senescence via the ROS axis during immunological aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32730228 |keywords=* Aging * Cellular senescence * Immunology * Inflammatory bowel disease * T cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598062 }} ==DDC== {{medline-entry |title=N-Acetyl Cysteine Attenuates the Sarcopenia and Muscle Apoptosis Induced by Chronic Liver Disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31530262 |mesh-terms=* Acetylcysteine * Aging * Animals * Apoptosis * Disease Models, Animal * End Stage Liver Disease * Humans * Mice * Muscle Fibers, Skeletal * Muscular Atrophy * Oxidative Stress * Pyridines * Sarcopenia |keywords=* Sarcopenia * UPP oxidative stress * apoptosis * chronic liver disease * hepatotoxin. |full-text-url=https://sci-hub.do/10.2174/1566524019666190917124636 }} ==DDO== {{medline-entry |title=New insights on the influence of free d-aspartate metabolism in the mammalian brain during prenatal and postnatal life. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32561430 |keywords=* Brain aging * Cell death * L-Glutamate * NMDA receptors * d-Aspartate * d-Aspartate oxidase |full-text-url=https://sci-hub.do/10.1016/j.bbapap.2020.140471 }} ==DDT== {{medline-entry |title=Prognostic Value of a Test of Central Auditory Function in Conversion from Mild Cognitive Impairment to Dementia. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32388503 |keywords=* Aging * Alzheimer’s disease * Auditory processing * Cognition * Dichotic Digits Test |full-text-url=https://sci-hub.do/10.1159/000506621 }} {{medline-entry |title=Uptake kinetics of four hydrophobic organic pollutants in the earthworm Eisenia andrei in aged laboratory-contaminated natural soils. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32061977 |mesh-terms=* Animals * DDT * Hexachlorocyclohexane * Hydrophobic and Hydrophilic Interactions * Kinetics * Oligochaeta * Polychlorinated Biphenyls * Pyrenes * Soil Pollutants |keywords=* Aging * BAFs * Bioaccumulation * HOCs * Laboratory-contaminated soils |full-text-url=https://sci-hub.do/10.1016/j.ecoenv.2020.110317 }} {{medline-entry |title=Adult exposure to insecticides causes persistent behavioral and neurochemical alterations in zebrafish. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31911208 |keywords=* Aging * Anxiety-related behavior * DDT * Neurobehavioral toxicology * Zebrafish |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061078 }} {{medline-entry |title=Second generation effects of larval metal pollutant exposure on reproduction, longevity and insecticide tolerance in the major malaria vector Anopheles arabiensis (Diptera: Culicidae). |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31910892 |mesh-terms=* Animals * Anopheles * Drug Resistance * Female * Fertility * Insecticides * Larva * Male * Metals * Reproduction * Water Pollutants |keywords=* Anopheles arabiensis * Insecticide resistance * Longevity * Transgenerational effects |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947826 }} {{medline-entry |title=Protective effect of Pedro-Ximénez must against p,p'-DDE-induced liver damages in aged Mus spretus mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31765701 |mesh-terms=* Aging * Animals * Antioxidants * Chemical and Drug Induced Liver Injury * Dichlorodiphenyl Dichloroethylene * Down-Regulation * Liver * Male * Mice * Oxidative Stress * Pesticides * Plant Extracts * Polyphenols * Transcriptome * Up-Regulation * Vitis |keywords=* Aging * Hepatoprotection * Mus spretus * Organochlorine * Oxidative damage * Pedro-ximénez grape must * Transcriptional analysis * p,p'-DDE |full-text-url=https://sci-hub.do/10.1016/j.fct.2019.110984 }} {{medline-entry |title=Low-dose endosulfan inhibits proliferation and induces senescence and pro-inflammatory cytokine production in human lymphocytes, preferentially impacting cytotoxic cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31589084 |mesh-terms=* Adult * B-Lymphocytes * Cell Proliferation * Cells, Cultured * Cellular Senescence * Cytokines * Dose-Response Relationship, Drug * Endosulfan * Female * Healthy Volunteers * Humans * Inflammation Mediators * Insecticides * Killer Cells, Natural * Male * Primary Cell Culture * T-Lymphocytes, Cytotoxic * Young Adult |keywords=* Endosulfan * Immunosenescence * NK cells * PBMC * cytotoxic cells * interferon * organochlorine pesticide * senescence |full-text-url=https://sci-hub.do/10.1080/1547691X.2019.1668513 }} ==DKC1== {{medline-entry |title=Successful liver transplantation in short telomere syndromes without bone marrow failure due to [[DKC1]] mutation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32166868 |keywords=* DKC1 * cell death: senescence * cirrhosis * hepatopulmonary syndrome * liver transplantation * short telomere syndromes |full-text-url=https://sci-hub.do/10.1111/petr.13695 }} ==DLD== {{medline-entry |title=A preliminary study of cerebral blood flow, aging and dementia in people with Down syndrome. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32996650 |keywords=* Alzheimer's disease * Down syndrome * aging * cerebral blood flow * neuroimaging |full-text-url=https://sci-hub.do/10.1111/jir.12784 }} ==DLGAP2== {{medline-entry |title=Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32877673 |keywords=* Alzheimer’s * Diversity Outbred * Dlgap2 * GWAS * aging * cognition * genetic diversity * resilience * spines * susceptibility * translational |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502175 }} ==DLX5== {{medline-entry |title=Inhibition of microRNA-27b-3p relieves osteoarthritis pain via regulation of KDM4B-dependent [[DLX5]]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32856377 |keywords=* adipogenic differentiation * cell senescence * distal-less homeobox 5 * lysine demethylase 4B * mesenchymal stem cells * microRNA-27b-3p * osteoarthritis pain * osteogenic differentiation |full-text-url=https://sci-hub.do/10.1002/biof.1670 }} ==DMD== {{medline-entry |title=Aldehyde dehydrogenases contribute to skeletal muscle homeostasis in healthy, aging, and Duchenne muscular dystrophy patients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32157826 |keywords=* Aging * Aldehyde dehydrogenase * Dog model * Duchenne muscular dystrophy * Human * Myogenic * Non-human primate * Skeletal muscle |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432589 }} {{medline-entry |title=Life expectancy at birth in Duchenne muscular dystrophy: a systematic review and meta-analysis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32107739 |mesh-terms=* Female * Humans * Life Expectancy * Male * Muscular Dystrophy, Duchenne * Parturition * Pregnancy * Prognosis * Quality of Life * Respiration, Artificial * Survival |keywords=* Mechanical ventilation * Mortality * Prognosis * Survival |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387367 }} {{medline-entry |title=Renal dysfunction can occur in advanced-stage Duchenne muscular dystrophy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31725904 |mesh-terms=* Adolescent * Adult * Aging * Child * Child, Preschool * Cystatin C * Disease Progression * Female * Heart Diseases * Heart Function Tests * Humans * Kidney Diseases * Kidney Function Tests * Male * Muscular Dystrophy, Duchenne * Risk Factors * Young Adult |keywords=* Duchenne muscular dystrophy * advanced stage * cystatin C * ejection fraction * fractional shortening * renal dysfunction |full-text-url=https://sci-hub.do/10.1002/mus.26757 }} ==DNAJB9== {{medline-entry |title=[[DNAJB9]] Inhibits p53-Dependent Oncogene-Induced Senescence and Induces Cell Transformation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32264658 |keywords=* DNAJB9 * RAS * p53 * senescence * transformation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191047 }} ==DNMT1== {{medline-entry |title=DNA Methyltransferase 1 ([[DNMT1]]) Function Is Implicated in the Age-Related Loss of Cortical Interneurons. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32793592 |keywords=* DNA methylation * GABA * aging * cerebral cortex * inhibitory interneurons * proteostasis * synapse * transcriptional control |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387673 }} ==DNMT3A== {{medline-entry |title=Epigenetic regulation of miR-29a/miR-30c/[[DNMT3A]] axis controls SOD2 and mitochondrial oxidative stress in human mesenchymal stem cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32961441 |keywords=* Cellular senescence * DNMT3A * Human mesenchymal stem cells * Mitochondrial oxidative stress * SOD2 * microRNAs |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509080 }} {{medline-entry |title=Collagens and DNA methyltransferases in mare endometrosis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31512314 |mesh-terms=* Aging * Animals * Collagen * DNA (Cytosine-5-)-Methyltransferases * DNA Methylation * Endometritis * Endometrium * Female * Fibrosis * Horse Diseases * Horses * RNA, Messenger |keywords=* DNA methylation * collagen * endometrium * epigenetic * fibrosis * mare |full-text-url=https://sci-hub.do/10.1111/rda.13515 }} {{medline-entry |title=Age-related clonal haemopoiesis is associated with increased epigenetic age. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31430471 |mesh-terms=* Aged * Aged, 80 and over * Aging * Epigenesis, Genetic * Female * Hematopoiesis * Humans * Longitudinal Studies * Male * Risk Factors * Scotland |full-text-url=https://sci-hub.do/10.1016/j.cub.2019.07.011 }} ==DNMT3L== {{medline-entry |title=Transient [[DNMT3L]] Expression Reinforces Chromatin Surveillance to Halt Senescence Progression in Mouse Embryonic Fibroblast. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32195249 |keywords=* DNA methyltransferase 3-like (DNMT3L) * chromatin surveillance * epigenetics * polycomb repressive complex 2 (PRC2) * senescence * transposable element (TE) |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064442 }} ==DOCK11== {{medline-entry |title=[Immunosenescence: The Forefront of Infection and Trophic Control]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32115558 |mesh-terms=* Aging * Animals * B-Lymphocytes * Cytokinesis * Gene Expression * Guanine Nucleotide Exchange Factors * Humans * Immunoglobulin M * Immunosenescence * Mice * Nutritional Status * Streptococcus pneumoniae |keywords=* B-1a B cell * dedicator of cytokinesis 11 * immunosenescence |full-text-url=https://sci-hub.do/10.1248/yakushi.19-00193-3 }} ==DPP4== {{medline-entry |title=Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-[[DPP4]] Axis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33013423 |keywords=* DNA damage * aging * cellular senescence * chronic obstructive pulmonary diseases * idiopathic pulmonary fibrosis * mitochondria * smokers * telomere |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510459 }} {{medline-entry |title=Dipeptidyl peptidase-4 inhibition improves endothelial senescence by activating AMPK/SIRT1/Nrf2 signaling pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32251672 |keywords=* Aging * Dipeptidyl peptidase-4 * Endothelium * Oxidative stress * Vascular |full-text-url=https://sci-hub.do/10.1016/j.bcp.2020.113951 }} {{medline-entry |title=Molecular crosstalk between Y5 receptor and neuropeptide Y drives liver cancer. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31999643 |keywords=* Aging * Cancer * Hepatology |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190991 }} ==DPP6== {{medline-entry |title=A novel structure associated with aging is augmented in the [[DPP6]]-KO mouse brain. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33225987 |keywords=* Aging dementia * Alzheimer’s disease * DPP6 * Presynaptic terminals |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682109 }} ==DPYSL2== {{medline-entry |title=Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31733664 |mesh-terms=* Alcohol Drinking * Alzheimer Disease * Amyloid beta-Protein Precursor * Animals * Behavior, Animal * Brain * Disease Models, Animal * Mice, Transgenic * tau Proteins |keywords=* Aging * Amyloid beta * Ethanol * GSK * Immunohistochemistry * Morris Water Maze * Prepulse inhibition * Self-administration * Tau pathology * Transgenic mouse model |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939615 }} ==DRD1== {{medline-entry |title=Impact of dopamine-related genetic variants on physical activity in old age - a cohort study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32448293 |mesh-terms=* Aged * Aged, 80 and over * Aging * Cohort Studies * Exercise * Humans * Receptors, Dopamine * Sedentary Behavior * Sweden |keywords=* Accelerometery * Aging * Dopamine * Genes * Physical activity * Sedentary behaviour |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245799 }} ==DRD2== {{medline-entry |title=Cortical thickness mediates the relationship between [[DRD2]] C957T polymorphism and executive function across the adult lifespan. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33179159 |keywords=* Aging * Cortical thickness * DRD2 * Dopamine * Executive function |full-text-url=https://sci-hub.do/10.1007/s00429-020-02169-5 }} {{medline-entry |title=The relationship of age and [[DRD2]] polymorphisms to frontostriatal brain activity and working memory performance. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31629117 |mesh-terms=* Aging * Brain * Humans * Memory, Short-Term * Polymorphism, Genetic * Receptors, Dopamine D2 |keywords=* Aging * C957T * DRD2 * Dopamine * Working memory * fMRI |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2019.08.022 }} ==DSPP== {{medline-entry |title=Effects of [i]p[/i]-Cresol on Senescence, Survival, Inflammation, and Odontoblast Differentiation in Canine Dental Pulp Stem Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32967298 |keywords=* aged teeth * apoptosis * dental pulp stem cells * differentiation * pulp regeneration * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555360 }} ==DST== {{medline-entry |title=Ancestral germen/soma distinction in microbes: Expanding the disposable soma theory of aging to all unicellular lineages. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32268207 |mesh-terms=* Aging * Animals * Biological Evolution * DNA Replication * Humans * Phylogeny |keywords=* Aging * Asymmetric cell division * DNA replication * Disposable Soma Theory * Epigenetics * Evolution * Germen/Soma * Prokaryotes * Protists * Rejuvenation * Unicellular |full-text-url=https://sci-hub.do/10.1016/j.arr.2020.101064 }} ==DUSP1== {{medline-entry |title=miR-1468-3p Promotes Aging-Related Cardiac Fibrosis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32348937 |keywords=* aging * cardiac fibrosis * dual-specificity phosphatases * extracellular matrix * miR-1468-3p * microRNA * p38 * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191129 }} ==DUSP8== {{medline-entry |title=MiR-21-5p/dual-specificity phosphatase 8 signalling mediates the anti-inflammatory effect of haem oxygenase-1 in aged intracerebral haemorrhage rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31400088 |mesh-terms=* Aging * Animals * Antagomirs * Anti-Inflammatory Agents * Cells, Cultured * Cerebral Hemorrhage * Dual-Specificity Phosphatases * HEK293 Cells * Heme Oxygenase-1 * Hemin * Humans * Male * MicroRNAs * Rats * Rats, Sprague-Dawley * Signal Transduction |keywords=* aging * dual-specificity phosphatase 8 * haem oxygenase-1 * intracerebral haemorrhage * microRNA |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826124 }} ==DUT== {{medline-entry |title=Simultaneous liquefaction, saccharification, and fermentation of L-lactic acid using aging paddy rice with hull by an isolated thermotolerant Enterococcus faecalis [[DUT]]1805. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32388689 |keywords=* Aging paddy rice with hull (APRH) * Corn steep liquor powder (CSLP) * High-thermotolerance * Lactic acid * Saccharification and fermentation (SLSF) * Simultaneous liquification |full-text-url=https://sci-hub.do/10.1007/s00449-020-02364-y }} ==DYRK1A== {{medline-entry |title=Altered age-linked regulation of plasma [[DYRK1A]] in elderly cognitive complainers (INSIGHT-preAD study) with high brain amyloid load. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32642550 |keywords=* Alzheimer's disease * aging * blood marker * immunometric test |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331462 }} ==E2F1== {{medline-entry |title=Regulation of [[E2F1]] activity via PKA-mediated phosphorylations. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33110360 |keywords=* E2F1 * PKA * cell cycle * forskolin * proliferation * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585165 }} {{medline-entry |title=Astragaloside IV ameliorates radiation-induced senescence via antioxidative mechanism. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32412100 |keywords=* cell signal pathway * nerve cells * radiation * senescence |full-text-url=https://sci-hub.do/10.1111/jphp.13284 }} ==ECD== {{medline-entry |title=Outcome of Descemet Membrane Endothelial Keratoplasty Using Corneas from Donors ≥80 Years of Age. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31837315 |mesh-terms=* Adolescent * Adult * Aged * Aged, 80 and over * Aging * Cell Count * Cornea * Descemet Stripping Endothelial Keratoplasty * Donor Selection * Endothelium, Corneal * Female * Fuchs' Endothelial Dystrophy * Humans * Male * Middle Aged * Retrospective Studies * Tissue Donors * Treatment Outcome * Visual Acuity * Young Adult |full-text-url=https://sci-hub.do/10.1016/j.ajo.2019.12.001 }} ==EDA== {{medline-entry |title=Interplay between aging, lung inflammation/remodeling, and fibronectin [[EDA]] in lung cancer progression. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33222614 |keywords=* Lung cancer * aging * fibronectin EDA * fibrosis * inflammation * lewis lung carcinoma * metastasis |full-text-url=https://sci-hub.do/10.1080/15384047.2020.1831372 }} {{medline-entry |title=Arousal Detection in Elderly People from Electrodermal Activity Using Musical Stimuli. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32854302 |keywords=* aging adults * arousal * electrodermal activity * musical genres |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7506973 }} {{medline-entry |title=The structure of agricultural microplastics (PT, PU and UF) and their sorption capacities for PAHs and PHE derivates under various salinity and oxidation treatments. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31761592 |mesh-terms=* Adsorption * Agriculture * Ecosystem * Environmental Pollutants * Hydrogen Peroxide * Microplastics * Models, Chemical * Naphthalenes * Organic Chemicals * Phenanthrenes * Plastics * Polycyclic Aromatic Hydrocarbons * Polyethylene * Polypropylenes * Polyurethanes * Polyuria * Pyrenes * Salinity |keywords=* Aging * Microplastics * Polycyclic aromatic hydrocarbons * Salinity * Sorption |full-text-url=https://sci-hub.do/10.1016/j.envpol.2019.113525 }} ==EDARADD== {{medline-entry |title=Age prediction in living: Forensic epigenetic age estimation based on blood samples. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32721866 |mesh-terms=* Adolescent * Adult * Aged * Aging * Child * Child, Preschool * CpG Islands * Cyclic Nucleotide Phosphodiesterases, Type 4 * DNA Methylation * Edar-Associated Death Domain Protein * Fatty Acid Elongases * Female * Forensic Genetics * Humans * Infant * LIM-Homeodomain Proteins * Male * Middle Aged * Muscle Proteins * Polymerase Chain Reaction * Transcription Factors * Young Adult |keywords=* Age the living * CpGs * DNA methylation age * Forensic epigenetics * Forensic sciences |full-text-url=https://sci-hub.do/10.1016/j.legalmed.2020.101763 }} ==EDF1== {{medline-entry |title=Silencing of FOREVER YOUNG FLOWER Like Genes from Phalaenopsis Orchids Promotes Flower Senescence and Abscission. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33237274 |keywords=* FOREVER YOUNG FLOWER * Phalaenopsis orchids * Abscission * Ethylene responses * MADS-box gene * Senescence |full-text-url=https://sci-hub.do/10.1093/pcp/pcaa145 }} ==EFS== {{medline-entry |title=The aging bladder phenotype is not the direct consequence of bladder aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31452236 |mesh-terms=* Adrenergic beta-Agonists * Aging * Animals * Carbachol * Cholinergic Agonists * Electric Stimulation * Female * Isoproterenol * Male * Mice * Mucous Membrane * Muscle Contraction * Myography * Phenotype * Receptor, Muscarinic M3 * Receptors, Adrenergic, beta-2 * Urinary Bladder * Urination |keywords=* aging * control physiology * resilience * urinary dysfunction |full-text-url=https://sci-hub.do/10.1002/nau.24149 }} ==EGF== {{medline-entry |title=Acute, exercise-induced alterations in cytokines and chemokines in the blood distinguish physically active and sedentary aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33289019 |keywords=* growth factors * human aging * inflammation * physical activity |full-text-url=https://sci-hub.do/10.1093/gerona/glaa310 }} {{medline-entry |title=Proinflammation, profibrosis, and arterial aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33103036 |keywords=* aging * artery * collagen * profibrosis * proinflammation * stiffening |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574637 }} {{medline-entry |title=Hinokitiol induces cell death and inhibits epidermal growth factor-induced cell migration and signaling pathways in human cervical adenocarcinoma. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32917321 |keywords=* Autophagy * Epidermal growth factor * Hinokitiol * Senescence * c-Jun N-Terminal kinase |full-text-url=https://sci-hub.do/10.1016/j.tjog.2020.07.013 }} {{medline-entry |title=Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro-inflammatory cytokines. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32323422 |keywords=* EGFR * HUVEC * IMR90 * Ras signaling * pro-inflammatory cytokine * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253070 }} {{medline-entry |title=Insulin Signaling in Intestinal Stem and Progenitor Cells as an Important Determinant of Physiological and Metabolic Traits in [i]Drosophila[/i]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32225024 |keywords=* ISC * fruit fly * insulin signaling pathway * lifespan * metabolism * midgut * progenitor cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226132 }} {{medline-entry |title=Different cellular properties and loss of nuclear signalling of porcine epidermal growth factor receptor with aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32001323 |mesh-terms=* Animals * ErbB Receptors * Signal Transduction * Swine |keywords=* Aging * Cell behaviour * EGF * EGFR * Signalling pathway |full-text-url=https://sci-hub.do/10.1016/j.ygcen.2020.113415 }} ==EGFR== {{medline-entry |title=Type I Collagen Aging Increases Expression and Activation of [[EGFR]] and Induces Resistance to Erlotinib in Lung Carcinoma in 3D Matrix Model. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33014812 |keywords=* EGFR * Erlotinib * Type I collagen * aging * resistance |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511549 }} {{medline-entry |title=Comparative effectiveness and cost-effectiveness of three first-line [[EGFR]]-tyrosine kinase inhibitors: Analysis of real-world data in a tertiary hospital in Taiwan. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32267879 |mesh-terms=* Afatinib * Aged * Carcinoma, Non-Small-Cell Lung * Cost-Benefit Analysis * Erlotinib Hydrochloride * Female * Gefitinib * Humans * Life Expectancy * Lung Neoplasms * Male * Propensity Score * Protein Kinase Inhibitors * Quality of Life * Survival Rate * Taiwan * Tertiary Care Centers |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141611 }} {{medline-entry |title=An Optogenetic Method to Study Signal Transduction in Intestinal Stem Cell Homeostasis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32201167 |mesh-terms=* Animals * Cell Communication * Cell Proliferation * Cells, Cultured * Drosophila Proteins * Drosophila melanogaster * Gene Expression Regulation * Gene Regulatory Networks * Homeostasis * Intestinal Mucosa * Light * Longevity * Optogenetics * Signal Transduction * Stem Cells |keywords=* Drosophila * EGFR * Toll * optogenetics * stem cells |full-text-url=https://sci-hub.do/10.1016/j.jmb.2020.03.019 }} {{medline-entry |title=Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31935369 |mesh-terms=* Adaptor Proteins, Signal Transducing * Animals * Apoptosis * Cell Cycle Proteins * Cell Line, Tumor * Cell Proliferation * Cell Survival * Cellular Senescence * Drug Resistance, Neoplasm * ErbB Receptors * Female * Gene Deletion * Gene Expression Regulation, Neoplastic * Humans * Lung Neoplasms * MAP Kinase Kinase 1 * Male * Mice * Mice, Knockout * Mutation * Signal Transduction * Transcription Factors * Transcription, Genetic |keywords=* YAP * dormancy * drug resistance * drug tolerance * epidermal growth factor receptor * lung cancer * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146079 }} {{medline-entry |title=Association between [[EGFR]] mutation and ageing, history of pneumonia and gastroesophageal reflux disease among patients with advanced lung cancer. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31634646 |mesh-terms=* Adult * Aged * Aged, 80 and over * Aging * Case-Control Studies * ErbB Receptors * Female * Gastroesophageal Reflux * Humans * Lung Neoplasms * Male * Middle Aged * Mutation * Pneumonia * Republic of Korea * Retrospective Studies * Risk Factors * Young Adult |keywords=* Ageing * EGFR mutation * GERD * Lung cancer * Pneumonia * Risk factors |full-text-url=https://sci-hub.do/10.1016/j.ejca.2019.09.010 }} ==EHF== {{medline-entry |title=Extended high frequency hearing and speech perception implications in adults and children. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32111404 |keywords=* Aging * Development * Extended high frequency audiometry * Otitis media * Ototoxicity * Speech in noise * Speech perception * Tinnitus |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431381 }} ==EIF4E== {{medline-entry |title=Transcriptomic evidence that insulin signalling pathway regulates the ageing of subterranean termite castes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32424344 |mesh-terms=* Aging * Animals * Insulin * Isoptera * Molecular Sequence Annotation * Signal Transduction * Transcriptome |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235038 }} ==ELF3== {{medline-entry |title=High Ambient Temperature Accelerates Leaf Senescence via PHYTOCHROME-INTERACTING FACTOR 4 and 5 in [i]Arabidopsis[/i]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32732458 |keywords=* Arabidopsis * PIF4 * phytochrome * senescence * temperature |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7398796 }} ==ELOVL2== {{medline-entry |title=[[ELOVL2]]: Not just a biomarker of aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33043173 |keywords=* Aging * Macular degeneration * Membrane structure * Polyunsaturated fatty acids |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7544151 }} {{medline-entry |title=The lipid elongation enzyme [[ELOVL2]] is a molecular regulator of aging in the retina. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31943697 |mesh-terms=* Aging * Animals * Cell Line * DNA Methylation * Decitabine * Down-Regulation * Fatty Acid Elongases * Fatty Acids, Unsaturated * Female * Humans * Macular Degeneration * Male * Mice * Mice, Transgenic * Point Mutation * Promoter Regions, Genetic * Retina * Retinal Pigment Epithelium |keywords=* DNA methylation * ELOVL2 * PUFA * age-related macular degeneration * aging * retina |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996962 }} ==EN1== {{medline-entry |title=Electrochemically detecting DNA methylation in the [[EN1]] gene promoter: implications for understanding ageing and disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33135722 |keywords=* Aging * biosensor * electrochemistry * methylation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670582 }} ==ENO1== {{medline-entry |title=Reduced expression of enolase-1 correlates with high intracellular glucose levels and increased senescence in cisplatin-resistant ovarian cancer cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32355541 |keywords=* ENO1 * Enolase * beta-Gal * cisplatin resistance * glucose * ovarian cancer * p21 * p53 * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191177 }} ==ENTPD7== {{medline-entry |title=Inhibition of lung cancer cells and Ras/Raf/MEK/ERK signal transduction by ectonucleoside triphosphate phosphohydrolase-7 ([[ENTPD7]]). |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31443651 |mesh-terms=* Adult * Aged * Animals * Apoptosis * Apyrase * Biomarkers * Cell Line, Tumor * Cell Proliferation * Cells, Cultured * Female * Gene Expression Regulation, Neoplastic * Gene Silencing * Humans * Lung Neoplasms * MAP Kinase Signaling System * Male * Mice * Mice, Inbred BALB C * Mice, Nude * Middle Aged * Mitogen-Activated Protein Kinases * Plasmids * Signal Transduction * Survival Analysis * raf Kinases * ras Proteins |keywords=* Ectonucleoside triphosphate phosphohydrolase-7 * Lung cancer * Proliferation * Senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708200 }} ==EPO== {{medline-entry |title=Regulation of muscle and metabolic physiology by hypothalamic erythropoietin independently of its peripheral action. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32029230 |keywords=* Aging * Brain * Erythropoietin * Glucose tolerance * Hypothalamus * Metabolism * Muscle * Obesity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938905 }} {{medline-entry |title=Red Blood Cell Lifespan Shortening in Patients with Early-Stage Chronic Kidney Disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31550724 |mesh-terms=* Anemia * Erythrocytes * Female * Humans * Male * Middle Aged * Renal Insufficiency, Chronic |keywords=* Chronic kidney disease * Erythropoietin * Levitt’s CO breath test * Red blood cell lifespan * Renal anemia |full-text-url=https://sci-hub.do/10.1159/000502525 }} ==ERCC1== {{medline-entry |title=Chronic Sildenafil Treatment Improves Vasomotor Function in a Mouse Model of Accelerated Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32630010 |keywords=* aging * cGMP * guanylate cyclase * hypertension * nitric oxide * phosphodiesterase * sildenafil * vascular dysfunction |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369923 }} {{medline-entry |title=Local endothelial DNA repair deficiency causes aging-resembling endothelial-specific dysfunction. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32202295 |mesh-terms=* Age Factors * Aging * Animals * Capillary Permeability * Cellular Senescence * Cyclin-Dependent Kinase Inhibitor p21 * DNA Damage * DNA Repair * DNA-Binding Proteins * Endonucleases * Endothelial Cells * Endothelium, Vascular * Mice, Inbred C57BL * Mice, Knockout * Nitric Oxide * Nitric Oxide Synthase Type III * Superoxides * Vascular Stiffness * Vasodilation |keywords=* DNA damage * aging * endothelial dysfunction * endothelium-dependent dilation * nitric oxide |full-text-url=https://sci-hub.do/10.1042/CS20190124 }} {{medline-entry |title=Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31981461 |keywords=* DNA repair * ERCC1-XPF * aging * cellular senescence * endogenous DNA damage * progeria |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059165 }} {{medline-entry |title=Deficiency in the DNA repair protein [[ERCC1]] triggers a link between senescence and apoptosis in human fibroblasts and mouse skin. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31737985 |keywords=* DNA damage repair * aging * cell death * senescence-associated secretory phenotype * tumor necrosis factor α |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059167 }} ==ERF== {{medline-entry |title=Angiotensin-Converting Enzyme Gene D/I Polymorphism in Relation to Endothelial Function and Endothelial-Released Factors in Chinese Women. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33041838 |keywords=* ACE D/I gene polymorphism * Chinese women * aging * endothelial function * endothelial-released factors * menopause |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526498 }} {{medline-entry |title=Projections of Ambient Temperature- and Air Pollution-Related Mortality Burden Under Combined Climate Change and Population Aging Scenarios: a Review. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32542573 |keywords=* Air pollution * Climate change * Mortality * Population aging * Projection * Temperature |full-text-url=https://sci-hub.do/10.1007/s40572-020-00281-6 }} {{medline-entry |title=Exome Sequencing Analysis Identifies Rare Variants in [i]ATM[/i] and [i]RPL8[/i] That Are Associated With Shorter Telomere Length. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32425970 |keywords=* ATM * RPL8 * aging * meta-analysis * telomere * whole exome sequencing |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204400 }} ==ERG== {{medline-entry |title=Effect of age and sex on neurodevelopment and neurodegeneration in the healthy eye: Longitudinal functional and structural study in the Long-Evans rat. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32882213 |keywords=* Aging * Electroretinography * Neurodegeneration * Neurodevelopment * Optical coherence tomography * Retina * Sex |full-text-url=https://sci-hub.do/10.1016/j.exer.2020.108208 }} {{medline-entry |title=Mice With a Combined Deficiency of Superoxide Dismutase 1 (Sod1), DJ-1 (Park7), and Parkin (Prkn) Develop Spontaneous Retinal Degeneration With Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31487745 |mesh-terms=* Aging * Animals * Biomarkers * Electroretinography * Enzyme-Linked Immunosorbent Assay * Immunohistochemistry * Malondialdehyde * Mice * Mice, Inbred C57BL * Mice, Knockout * Microscopy, Electron, Transmission * Mitochondria * Oxidative Stress * Protein Deglycase DJ-1 * Retina * Retinal Degeneration * Retinal Pigment Epithelium * Superoxide Dismutase-1 * Tomography, Optical Coherence * Ubiquitin-Protein Ligases |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733419 }} ==ESPL1== {{medline-entry |title=Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32574725 |keywords=* Genomics * Longevity * Pedigree * Rare variant sharing * Utah population database |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461696 }} ==ETS1== {{medline-entry |title=The transcription factor [[ETS1]] promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31659122 |mesh-terms=* ATP Binding Cassette Transporter, Subfamily B * Animals * Apoptosis * Cellular Senescence * Hepatocytes * Humans * Lipopolysaccharides * Liver * Mice * Proto-Oncogene Protein c-ets-1 * Transcription Factors * bcl-X Protein |keywords=* BCL2 like 1 (BCL2L1) * apoptosis * cholangiocyte * chromatin modification * epigenetics * gene expression * primary sclerosing cholangitis (PSC) * senescence * transcription factor |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901313 }} ==EVL== {{medline-entry |title=Health Years in Total: A New Health Objective Function for Cost-Effectiveness Analysis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31952678 |mesh-terms=* Cost-Benefit Analysis * Health Care Costs * Health Status * Health Status Indicators * Humans * Life Expectancy * Quality of Life * Quality-Adjusted Life Years * Time Factors |keywords=* cost-effectiveness * equal value of life * health years in total * quality-adjusted life-year * thresholds |full-text-url=https://sci-hub.do/10.1016/j.jval.2019.10.014 }} ==EZH2== {{medline-entry |title=Linking gene expression and phenotypic changes in the developmental and evolutionary origins of osteosclerosis in the ribs of bowhead whales (Balaena mysticetus). |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32729176 |keywords=* Cetacea * aging * bone * hyperostosis * osteoblasts * whales |full-text-url=https://sci-hub.do/10.1002/jez.b.22990 }} {{medline-entry |title=[[EZH2]] is involved in vulnerability to neuroinflammation and depression-like behaviors induced by chronic stress in different aged mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32553389 |keywords=* Aging * CUMS * Cytokines * Depresion * EZH2 * Microglia |full-text-url=https://sci-hub.do/10.1016/j.jad.2020.03.154 }} {{medline-entry |title=A positive feedback loop between [[EZH2]] and NOX4 regulates nucleus pulposus cell senescence in age-related intervertebral disc degeneration. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32025238 |keywords=* Epigenetic histone modification * Intervertebral disc degeneration * Nucleus pulposus cell senescence * Wnt/β-catenin signaling pathway |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995653 }} {{medline-entry |title=Perinatal exposure to bisphenol A impacts in the mammary gland morphology of adult Mongolian gerbils. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31917966 |mesh-terms=* Actins * Aging * Animals * Benzhydryl Compounds * Cell Proliferation * Collagen * Enhancer of Zeste Homolog 2 Protein * Female * Gerbillinae * Histones * Mammary Glands, Animal * Phenols * Pregnancy * Prenatal Exposure Delayed Effects |keywords=* BPA * EZH2 * Environment pollutant * Estrogen * Morphologic alterations * Phospho-histone-h3 |full-text-url=https://sci-hub.do/10.1016/j.yexmp.2020.104374 }} ==F2== {{medline-entry |title=Environmental risk assessment of glufosinate-resistant soybean by pollen-mediated gene flow under field conditions in the region of the genetic origin. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33189381 |keywords=* Glufosinate resistance * Relative fitness * Seed longevity * Transgene flow * Weed risk |full-text-url=https://sci-hub.do/10.1016/j.scitotenv.2020.143073 }} {{medline-entry |title=Gestational arsenite exposure augments hepatic tumors of C3H mice by promoting senescence in F1 and [[F2]] offspring via different pathways. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33010264 |keywords=* Arsenic * Liver * Multigenerational Effect * SASP * Senescence * Tumor |full-text-url=https://sci-hub.do/10.1016/j.taap.2020.115259 }} {{medline-entry |title=Familial Longevity is Associated with an Attenuated Thyroidal Response to Recombinant Human Thyroid Stimulating Hormone. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32303766 |keywords=* Thyroid * longevity * recombinant human TSH * responsivity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239378 }} {{medline-entry |title=Conclusions from a behavioral aging study on male and female [[F2]] hybrid mice on age-related behavior, buoyancy in water-based tests, and an ethical method to assess lifespan. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31509518 |mesh-terms=* Adiposity * Aging * Animals * Exploratory Behavior * Female * Male * Memory * Mice, Inbred BALB C * Mice, Inbred C57BL * Swimming |keywords=* F2 hybrid mice * aging * exploratory activity * sex comparison * water-based behavioral tests |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756906 }} {{medline-entry |title=In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31428698 |mesh-terms=* Acetaminophen * Aging * Animals * Animals, Newborn * Cell Proliferation * Female * Fertility * Forkhead Box Protein O3 * Germ Cells * Ibuprofen * Luteolysis * Mice * Ovary * Pregnancy * Prenatal Exposure Delayed Effects * Proto-Oncogene Proteins c-akt * Reproduction * Signal Transduction |keywords=* Infertility * Oogenesis * Risk factors |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692356 }} ==F3== {{medline-entry |title=A Comprehensive Analysis of Age and Gender Effects in European Portuguese Oral Vowels. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33293174 |keywords=* Acoustic * Aging voice * European Portuguese * Oral vowel |full-text-url=https://sci-hub.do/10.1016/j.jvoice.2020.10.021 }} {{medline-entry |title=Prenatal exposure to an environmentally relevant phthalate mixture accelerates biomarkers of reproductive aging in a multiple and transgenerational manner in female mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33129917 |keywords=* cyclicity * hormone * mixture * ovary * phthalates * reproductive aging * transgenerational |full-text-url=https://sci-hub.do/10.1016/j.reprotox.2020.10.009 }} {{medline-entry |title=Combining Frontal Transcranial Direct Current Stimulation With Walking Rehabilitation to Enhance Mobility and Executive Function: A Pilot Clinical Trial. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32808403 |keywords=* Aging * cognition * rehabilitation * transcranial direct current stimulation * walking |full-text-url=https://sci-hub.do/10.1111/ner.13250 }} {{medline-entry |title=Multigenerational exposure to TiO nanoparticles in soil stimulates stress resistance and longevity of survived C. elegans via activating insulin/IGF-like signaling. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32203849 |mesh-terms=* Animals * Caenorhabditis elegans * Caenorhabditis elegans Proteins * Insulin * Longevity * Nanoparticles * Oxidative Stress * Soil * Titanium |keywords=* Insulin/IGF-like signaling * Longevity * Multigenerational toxicity * Nanomaterial * Soil nematode |full-text-url=https://sci-hub.do/10.1016/j.envpol.2020.114376 }} {{medline-entry |title=Co-expression network analysis identified hub genes critical to triglyceride and free fatty acid metabolism as key regulators of age-related vascular dysfunction in mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31514170 |mesh-terms=* Aging * Animals * Fatty Acids, Nonesterified * Gene Expression Profiling * Gene Expression Regulation * Gene Regulatory Networks * Lipid Metabolism * Mice * Microarray Analysis * Signal Transduction * Triglycerides * Vascular Diseases |keywords=* aging * co-expression network * hub gene * module * mouse * vascular dysfunction |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781998 }} ==F5== {{medline-entry |title=Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32039401 |keywords=* ALP, alkaline phosphatase * ALT, alanine aminotransferase * Aging * BMI, body mass index * DNAm, DNA methylation * ELF, enhanced liver fibrosis * FDR, false discovery rate * GGT, gamma-glutamyltransferase * IBD, inflammatory bowel disease * IL, interleukin * LOXL2, lysyl oxidase-like-2 * NASH, non-alcoholic steatohepatitis * PSC, primary sclerosing cholangitis * SMA, smooth muscle actin * UDCA, ursodeoxycholic acid * biomarker * inflammatory bowel disease * primary sclerosing cholangitis * prognosis * ursodeoxycholic acid |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005566 }} {{medline-entry |title=Fermentation of Blackberry with [i]L. plantarum[/i] JBMI [[F5]] Enhance the Protection Effect on UVB-Mediated Photoaging in Human Foreskin Fibroblast and Hairless Mice through Regulation of MAPK/NF-κB Signaling. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31614689 |mesh-terms=* Animals * Cell Line * Cell Survival * Female * Fermentation * Fibroblasts * Foreskin * Fruit * Lactobacillus plantarum * Male * Mice * Mice, Hairless * Plant Extracts * Rubus * Skin Aging * Ultraviolet Rays |keywords=* Lactobacillus plantarum * MMPs * fermented blackberry * photoaging * skin aging * type I procollagen |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835613 }} ==F7== {{medline-entry |title=The Pattern of Mu Rhythm Modulation During Emotional Destination Memory: Comparison Between Mild Cognitive Impairment Patients and Healthy Controls. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31524160 |mesh-terms=* Aged * Aging * Cognitive Dysfunction * Electroencephalography * Emotions * Female * Frontal Lobe * Humans * Male * Memory * Neurophysiological Monitoring * Neuropsychological Tests * Task Performance and Analysis * Temporal Lobe |keywords=* Emotional destination memory * Mu suppression * fronto-temporal * mild cognitive impairment * mirror neurons |full-text-url=https://sci-hub.do/10.3233/JAD-190311 }} ==FAAH== {{medline-entry |title=Endocannabinoid genetic variation enhances vulnerability to THC reward in adolescent female mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32095523 |mesh-terms=* Aging * Amidohydrolases * Animals * Axons * Choice Behavior * Dronabinol * Endocannabinoids * Female * Genetic Variation * Male * Mice, Inbred C57BL * Nerve Net * Nucleus Accumbens * Polymorphism, Single Nucleotide * Receptor, Cannabinoid, CB1 * Reward * Tyrosine 3-Monooxygenase * Ventral Tegmental Area |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015690 }} ==FABP3== {{medline-entry |title=[[FABP3]]-mediated membrane lipid saturation alters fluidity and induces ER stress in skeletal muscle with aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33168829 |mesh-terms=* Aging * Animals * Cell Line * Endoplasmic Reticulum Stress * Eukaryotic Initiation Factor-2 * Fatty Acid Binding Protein 3 * Female * Gene Knockdown Techniques * Lipidomics * Membrane Fluidity * Membrane Lipids * Mice, Inbred C57BL * Mice, Knockout * Muscle, Skeletal * Myoblasts * Phospholipids * Protein-Serine-Threonine Kinases * Sarcopenia * Up-Regulation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7653047 }} {{medline-entry |title=Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing [[FABP3]]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143524 |keywords=* Adipogenesis * autophagy * bone metabolism * fabp3 * mesenchymal stem cell * optineurin * osteogenesis * osteoporosis * senescence |full-text-url=https://sci-hub.do/10.1080/15548627.2020.1839286 }} {{medline-entry |title=Myokines as biomarkers of frailty and cardiovascular disease risk in females. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32017952 |keywords=* Aging * Biomarkers * Cardiovascular disease * Females * Frailty * Myokines |full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110859 }} ==FADS1== {{medline-entry |title=Aging and [[FADS1]] polymorphisms decrease the biosynthetic capacity of long-chain PUFAs: A human trial using [U- C]linoleic acid. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31492428 |mesh-terms=* Adult * Age Factors * Aged * Aging * Alleles * Arachidonic Acid * Area Under Curve * Fatty Acid Desaturases * Fatty Acids, Unsaturated * Female * Healthy Volunteers * Humans * Linoleic Acid * Male * Polymorphism, Single Nucleotide |keywords=* Aging * Arachidonic acid * Fatty acid conversion * Linoleic acid * Lipid metabolism * Long-chain polyunsaturated fatty acid |full-text-url=https://sci-hub.do/10.1016/j.plefa.2019.07.003 }} ==FANCD2== {{medline-entry |title=TFG-maintaining stability of overlooked [[FANCD2]] confers early DNA-damage response. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33099537 |keywords=* DNA damage response * FANCD2 * TFG * aging and cancer |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655164 }} ==FAP== {{medline-entry |title=Rapamycin Extends Life Span in Apc Colon Cancer [[FAP]] Model. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33132009 |keywords=* Aging * Crypt stem cells * eEF2K * mTORC1 * rpS6 |full-text-url=https://sci-hub.do/10.1016/j.clcc.2020.08.006 }} {{medline-entry |title=Exercise enhances skeletal muscle regeneration by promoting senescence in fibro-adipogenic progenitors. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32060352 |mesh-terms=* Aging * Animals * Apoptosis * Exercise Therapy * Female * Humans * Mesenchymal Stem Cells * Mice * Mice, Inbred BALB C * Mice, Inbred C57BL * Muscle, Skeletal * Muscular Diseases * Regeneration |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021787 }} {{medline-entry |title=Control of Muscle Fibro-Adipogenic Progenitors by Myogenic Lineage is Altered in Aging and Duchenne Muscular Dystrophy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31865646 |mesh-terms=* Adipogenesis * Adolescent * Adult * Adult Stem Cells * Aged * Aging * Cells, Cultured * Child * Child, Preschool * Female * Humans * Infant * Male * Middle Aged * Muscle Development * Muscular Dystrophy, Duchenne * Myoblasts * Young Adult |keywords=Adipocytes; Myofibroblasts; Muscle progenitors; Myopathies |full-text-url=https://sci-hub.do/10.33594/000000196 }} ==FAS== {{medline-entry |title=Five-year change in maximum tongue pressure and physical function in community-dwelling elderly adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32952883 |keywords=* Aging * Biological age * Elderly * Physical function * Tongue pressure |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486543 }} {{medline-entry |title=Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32064756 |keywords=* MDM2 * Senescence * USP7 * apoptosis * p53 * senolytics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059172 }} ==FES== {{medline-entry |title=An outpatient Tai Chi program: Effects on veterans' functional outcomes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33241873 |keywords=* Tai Chi * balance * exercise * gait * geriatrics |full-text-url=https://sci-hub.do/10.1111/nuf.12532 }} {{medline-entry |title=Gait Function in Adults Aged 50 Years and Older With Spina Bifida. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33166524 |keywords=* Adult * Aging * Gait analysis * Myelomeningocele * Rehabilitation |full-text-url=https://sci-hub.do/10.1016/j.apmr.2020.10.118 }} {{medline-entry |title=A Single Question as a Screening Tool to Assess Fear of Falling in Young-Old Community-Dwelling Persons. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32165062 |keywords=* FES-I * elderly * fear of falling * healthy aging * older adults |full-text-url=https://sci-hub.do/10.1016/j.jamda.2020.01.101 }} {{medline-entry |title=Fall-related efficacy is a useful and independent index to detect fall risk in Japanese community-dwelling older people: a 1-year longitudinal study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31664911 |mesh-terms=* Accidental Falls * Activities of Daily Living * Aged * Aging * Female * Geriatric Assessment * Humans * Independent Living * Japan * Longitudinal Studies * Male * Physical Functional Performance * Postural Balance * Risk Factors * Walking Speed |keywords=* Accidental falls * Aged * Fall-related efficacy * Japanese * Physical performance |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820944 }} {{medline-entry |title=Investigating Changes in Real-time Conscious Postural Processing by Older Adults during Different Stance Positions Using Electroencephalography Coherence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31514583 |mesh-terms=* Accidental Falls * Aged * Aging * Brain * Electroencephalography * Fear * Female * Humans * Male * Movement * Postural Balance * Posture |full-text-url=https://sci-hub.do/10.1080/0361073X.2019.1664450 }} ==FEV== {{medline-entry |title=Prediction of Lung Function in Adolescence Using Epigenetic Aging: A Machine Learning Approach. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33182250 |keywords=* epigenetic aging * feature selection * hyperparameter tuning * lung function * machine learning |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7712054 }} {{medline-entry |title=Effect of Age on the Efficacy and Safety of Once-Daily Single-Inhaler Triple Therapy Fluticasone Furoate/Umeclidinium/Vilanterol in Patients With Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis of the IMPACT Trial. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33031829 |keywords=* COPD * aging * exacerbations * safety * single-inhaler triple therapy |full-text-url=https://sci-hub.do/10.1016/j.chest.2020.09.253 }} {{medline-entry |title=A comprehensive analysis of factors related to lung function in older adults: Cross-sectional findings from the Canadian Longitudinal Study on Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33010732 |keywords=* Aging * Determinants * Lung function * Sex * Spirometry |full-text-url=https://sci-hub.do/10.1016/j.rmed.2020.106157 }} {{medline-entry |title=Risk factors associated with the detection of pulmonary emphysema in older asymptomatic respiratory subjects. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32517728 |keywords=* Aging * COPD * Klotho * Pulmonary emphysema * Risk factors * Telomere length |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285611 }} {{medline-entry |title=Tiotropium Respimat Efficacy and Safety in Asthma: Relationship to Age. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32320797 |keywords=* Aging * Asthma * Long-acting muscarinic antagonist * Long-acting β(2)-agonists * Pharmacotherapy |full-text-url=https://sci-hub.do/10.1016/j.jaip.2020.04.013 }} {{medline-entry |title=Current Bronchodilator Responsiveness Criteria Underestimate Asthma in Older Adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32071132 |keywords=* aging * albuterol * asthma * bronchodilator effect * lung diseases * older adult * spirometry |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538007 }} {{medline-entry |title=Physical performances show conflicting associations in aged manual workers. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32042126 |mesh-terms=* Aged * Aging * Body Composition * Body Mass Index * Cardiorespiratory Fitness * Cross-Sectional Studies * Hand Strength * Humans * Lung * Male * Middle Aged * Physical Functional Performance |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010773 }} {{medline-entry |title=[[FEV]] as a Standalone Spirometric Predictor and the Attributable Fraction for Death in Older Persons. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31662447 |keywords=* aging * average attributable fraction * death * relative risk * spirometry |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055488 }} {{medline-entry |title=An Individualized Prediction Model for Long-term Lung Function Trajectory and Risk of COPD in the General Population. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31542453 |mesh-terms=* Adult * Age Factors * Aging * Alcohol Drinking * Algorithms * Alkaline Phosphatase * Body Height * Bronchodilator Agents * Cigarette Smoking * Cohort Studies * Cough * Dyspnea * Electrocardiography * Female * Forced Expiratory Volume * Hematocrit * Humans * Leukocyte Count * Longitudinal Studies * Lung * Machine Learning * Male * Middle Aged * Pulmonary Disease, Chronic Obstructive * Risk Assessment * Serum Albumin * Serum Globulins * Sex Factors * Spirometry * Triglycerides * Vital Capacity |keywords=* COPD * FEV(1) * FEV(1)/FVC * airflow limitation * lung function * predictive modeling |full-text-url=https://sci-hub.do/10.1016/j.chest.2019.09.003 }} {{medline-entry |title=Telomere length and lung function in a population-based cohort of children and mid-life adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31456360 |mesh-terms=* Aged * Asthma * Body Mass Index * Child * Cohort Studies * Cross-Sectional Studies * Exercise * Female * Forced Expiratory Volume * Humans * Lung * Male * Respiratory Function Tests * Risk Factors * Smoking * Spirometry * Telomere * Vital Capacity |keywords=* aging * cell senescence * life course * national cohort * spirometry |full-text-url=https://sci-hub.do/10.1002/ppul.24489 }} ==FGA== {{medline-entry |title=Goal Pursuit, Goal Adjustment, and Pain in Middle-Aged Adults Aging With Physical Disability. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31718416 |mesh-terms=* Adaptation, Psychological * Aged * Aging * Depression * Disabled Persons * Female * Goals * Humans * Male * Middle Aged * Multiple Sclerosis * Muscular Dystrophies * Pain * Postpoliomyelitis Syndrome * Spinal Cord Injuries |keywords=* aging * disability * goal management * pain * psychological adaptation |full-text-url=https://sci-hub.do/10.1177/0898264319827142 }} {{medline-entry |title=Tenacious Goal Pursuit, Flexible Goal Adjustment, and Life Satisfaction Among Chinese Older Adult Couples. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31547780 |keywords=* flexible goal adjustment * life satisfaction * older couples * self-perceptions of aging * tenacious goal pursuit |full-text-url=https://sci-hub.do/10.1177/0164027519876125 }} ==FGF19== {{medline-entry |title=Bile acid receptor agonists in primary biliary cholangitis: Regulation of the cholangiocyte secretome and downstream T cell differentiation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32123836 |keywords=* FGF19 * FXR * TGR5 * autoimmunity * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996327 }} ==FGF2== {{medline-entry |title=The influence of fibroblast growth factor 2 on the senescence of human adipose-derived mesenchymal stem cells during long-term culture. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31840944 |keywords=* cell proliferation * cellular senescence * fibroblast growth factor 2 * long-term culture * mesenchymal stem cell |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103622 }} ==FGF21== {{medline-entry |title=Differential effects of sulfur amino acid-restricted and low-calorie diets on gut microbiome profile and bile acid composition in male C57BL6/J mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33106871 |keywords=* Clostridales * firmicutes * lifespan * methionine restriction * sulfur metabolism |full-text-url=https://sci-hub.do/10.1093/gerona/glaa270 }} {{medline-entry |title=Relationship between physical activity and circulating fibroblast growth factor 21 in middle-aged and older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32911033 |keywords=* Accelerometer * Activity intensity * Aging * FGF21 * Physical activity |full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111081 }} {{medline-entry |title=Exercise and dietary intervention ameliorate high-fat diet-induced NAFLD and liver aging by inducing lipophagy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32863214 |keywords=* Aging * Exercise * FGF21 * Lipophagy * Nonalcoholic fatty liver disease (NAFLD) |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365984 }} {{medline-entry |title=Mitochondria, immunosenescence and inflammaging: a role for mitokines? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32757036 |keywords=* Human ageing * Immunosenescence * Inflammaging * Mitochondrial metabolism * Mitokines |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666292 }} {{medline-entry |title=Age-at-onset-dependent effects of sulfur amino acid restriction on markers of growth and stress in male F344 rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32573078 |keywords=* ER stress * cysteine * glutathione * hormesis * lifespan * methionine * trade-offs * translational |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426777 }} {{medline-entry |title=Fibroblast growth factor 21 prolongs lifespan and improves stress tolerance in the silkworm, [i]Bombyx mori[/i]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32309367 |keywords=* Bombyx mori * fibroblast growth factor 21 (FGF21) * lifespan * oxidation resistance * stress tolerance |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154471 }} {{medline-entry |title=Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31723038 |mesh-terms=* Animals * Butyrates * Fecal Microbiota Transplantation * Fibroblast Growth Factors * Gastrointestinal Microbiome * Germ-Free Life * Hippocampus * Intestines * Liver * Longevity * Male * Metabolome * Mice, Inbred C57BL * Microtubule-Associated Proteins * Neurogenesis * Neurons * Neuropeptides * Phenotype * Proton Magnetic Resonance Spectroscopy |full-text-url=https://sci-hub.do/10.1126/scitranslmed.aau4760 }} {{medline-entry |title=Fibroblast Growth Factor 21 Mediates the Associations between Exercise, Aging, and Glucose Regulation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31490857 |mesh-terms=* Adiponectin * Adult * Aging * Blood Glucose * Blood Pressure * Body Mass Index * Diabetes Mellitus, Type 2 * Exercise * Female * Fibroblast Growth Factors * Glucose Tolerance Test * Humans * Insulin * Lipids * Male * Middle Aged * Risk Factors |full-text-url=https://sci-hub.do/10.1249/MSS.0000000000002150 }} {{medline-entry |title=Effects of Moderate Chronic Food Restriction on the Development of Postprandial Dyslipidemia with Ageing. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31405194 |mesh-terms=* Adiposity * Aging * Animals * Basic Helix-Loop-Helix Leucine Zipper Transcription Factors * Blood Glucose * Diet, Fat-Restricted * Dietary Fats * Disease Models, Animal * Dyslipidemias * Glucagon * Insulin * Lipids * Liver * Metabolic Syndrome * Postprandial Period * Rats * Rats, Wistar * Triglycerides |keywords=* ChREBP * adipose tissue * ageing * oral lipid loading test * postprandial hypertrigliceridemia * postprandial thermogenesis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723802 }} ==FGF23== {{medline-entry |title=Phosphate as a Pathogen of Arteriosclerosis and Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33028781 |keywords=* Aging * Calciprotein particles (CPPs) * Fibroblast growth factor-23 (FGF23) * Inflammation * Klotho * Phosphate * Vascular calcification |full-text-url=https://sci-hub.do/10.5551/jat.RV17045 }} {{medline-entry |title=Plasma Soluble αKlotho, Serum Fibroblast Growth Factor 23, and Mobility Disability in Community-Dwelling Older Adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32405607 |keywords=* aging * chronic kidney disease * fibroblast growth factor 23 * mobility disability * αKlotho |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209777 }} {{medline-entry |title=Protective effect of Polygonatum sibiricum Polysaccharide on D-galactose-induced aging rats model. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32042011 |mesh-terms=* Aging * Animals * Calcium * Dietary Carbohydrates * Fibroblast Growth Factors * Galactose * Glucuronidase * Male * Oxidative Stress * Phosphorus * Phytochemicals * Polygonatum * Polysaccharides * Protective Agents * Rats * Rats, Sprague-Dawley |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010663 }} {{medline-entry |title=[[FGF23]] expression is stimulated in transgenic α-Klotho longevity mouse model. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31801907 |mesh-terms=* Aldosterone * Animals * Bone and Bones * Cardiovascular Diseases * Disease Models, Animal * Female * Fibroblast Growth Factors * Gene Knockout Techniques * Glucuronidase * Kidney * Longevity * Male * Mice * Mice, Inbred C57BL * Mice, Transgenic * Osteoblasts * Protein Isoforms * Transcriptome |keywords=* Bone Biology * Cardiovascular disease |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962016 }} {{medline-entry |title=Fibroblast growth factor 23 and symmetric dimethylarginine concentrations in geriatric cats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31568615 |mesh-terms=* Aging * Animals * Arginine * Biomarkers * Cats * Cross-Sectional Studies * Female * Fibroblast Growth Factors * Male * Reference Values * Retrospective Moral Judgment |keywords=* azotemia * feline * phosphate * renal |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872607 }} ==FGFR1== {{medline-entry |title=Alignment of Alzheimer's disease amyloid β-peptide and klotho. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32999998 |keywords=* Alzheimer’s disease * HSV-1 * aging * alignment * klotho * neurodegeneration * neuroinflammation * protein * ubiquitin * β-amyloid |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521834 }} {{medline-entry |title=Satellite cell-specific ablation of Cdon impairs integrin activation, FGF signalling, and muscle regeneration. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32103583 |keywords=* Cdon * Cellular senescence * FGFR * Growth factor signalling * Muscle regeneration * Satellite cell |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432598 }} ==FGFR4== {{medline-entry |title=[[FGFR4]] Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Proliferation and Invasion While Inducing Senescence: Evidence for Senolytic Therapy Potential in Pancreatic Cancer. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33066597 |keywords=* FGFR4 * FGFR4 inhibitor * growth * invasion * pancreatic cancer * senescence * senolytic therapy |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7602396 }} ==FGR== {{medline-entry |title=Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32452402 |keywords=* Aurora kinase * Cellular senescence * FGR * Preeclampsia |full-text-url=https://sci-hub.do/10.1016/j.placenta.2020.04.012 }} ==FH== {{medline-entry |title=Genetic Factors of Alzheimer's Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33252089 |keywords=* APOE4 * Aging * Mediterranean diet * cognitive decline * functional food * lamb * nutrition policy * preventive medicine * red wine * salt |full-text-url=https://sci-hub.do/10.3233/JAD-201058 }} {{medline-entry |title=Volumetric alterations in the hippocampal subfields of subjects at increased risk of dementia. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32311609 |mesh-terms=* Adult * Aging * Alzheimer Disease * Apolipoproteins E * Atrophy * Dementia * Diffusion Magnetic Resonance Imaging * Educational Status * Female * Genotype * Hippocampus * Humans * Male * Middle Aged * Organ Size * Risk |keywords=* Alzheimer's disease * Dementia * Hippocampal subfields * Hippocampus * Preclinical dementia |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.03.006 }} {{medline-entry |title=Macroscopic hematuria as a risk factor for hypertension in ageing people with hemophilia and a family history of hypertension. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32118768 |mesh-terms=* Adult * Aged * Aged, 80 and over * Aging * Cross-Sectional Studies * Female * Hematuria * Hemophilia A * Humans * Hypertension * Israel * Logistic Models * Male * Middle Aged * Risk Factors |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7478422 }} {{medline-entry |title=LDL Receptor Deficiency Does not Alter Brain Amyloid-β Levels but Causes an Exacerbation of Apoptosis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31815695 |mesh-terms=* Aging * Amyloid beta-Protein Precursor * Animals * Apoptosis * Brain Chemistry * Caspase 3 * Cholesterol * Gene Expression * Hippocampus * Male * Maze Learning * Mice * Mice, Inbred C57BL * Mice, Knockout * Prefrontal Cortex * Receptors, LDL |keywords=* Familial hypercholesterolemia * LDLr-/- mice * amyloid-β * apoptosis * memory impairment |full-text-url=https://sci-hub.do/10.3233/JAD-190742 }} ==FNDC5== {{medline-entry |title=Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33053231 |keywords=* BONE-MUSCLE INTERACTIONS * IRISIN * OSTEOPOROSIS * SARCOPENIA * SENESCENCE |full-text-url=https://sci-hub.do/10.1002/jbmr.4192 }} {{medline-entry |title=[Investigation of signal molecules in saliva: prospects of application for diagnostics of myocardial infarction and the aging rate of different age people.] |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31512422 |mesh-terms=* Aged * Aging * Biomarkers * Cytokines * Humans * Middle Aged * Myocardial Infarction * Saliva * Tumor Necrosis Factor-alpha |keywords=* aging * diagnosis * myocardial infarction * saliva * signaling molecules }} ==FOS== {{medline-entry |title=Muscle atrophy-related myotube-derived exosomal microRNA in neuronal dysfunction: Targeting both coding and long noncoding RNAs. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32233025 |keywords=* HIF-1α-AS2 * aging * lncRNAs * miR-29b-3p * muscle atrophy |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253071 }} ==FOSL2== {{medline-entry |title=LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1α-FOXO4-p21-dependent signaling axis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32149459 |keywords=* GUARDIN * LRP130-PGC1α * cellular senescence * lncRNAs * p21 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132339 }} ==FOXA1== {{medline-entry |title=Analyses of an epigenetic switch involved in the activation of pioneer factor [[FOXA1]] leading to the prognostic value of estrogen receptor and [[FOXA1]] co-expression in breast cancer. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31562808 |mesh-terms=* Breast Neoplasms * Down-Regulation * Epigenesis, Genetic * Female * Gene Expression Regulation, Neoplastic * Hepatocyte Nuclear Factor 3-alpha * Humans * Middle Aged * Prognosis * RNA, Messenger * Receptor, ErbB-2 * Receptors, Estrogen * Receptors, Progesterone * Transcriptome * Up-Regulation |keywords=* FOXA1 * age-related diseases * aging * breast cancer * hormone receptor * methylation * prognosis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782010 }} ==FOXM1== {{medline-entry |title=Sirtuin 6 deficiency induces endothelial cell senescence via downregulation of forkhead box M1 expression. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33171439 |keywords=* FOXM1 * SIRT6 * cell cycle * endothelial cell * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7695388 }} ==FOXN1== {{medline-entry |title=Thymic rejuvenation via [[FOXN1]]-reprogrammed embryonic fibroblasts (FREFs) to counteract age-related inflammation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32790650 |keywords=* Aging * Immunology * Immunotherapy * T cell development |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526556 }} ==FOXO1== {{medline-entry |title=l-Theanine attenuates liver aging by inhibiting advanced glycation end products in d-galactose-induced rats and reversing an imbalance of oxidative stress and inflammation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31899338 |keywords=* AGEs * Inflammatory response * Liver aging * Oxidative stress * l-Theanine |full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110823 }} ==FOXO3== {{medline-entry |title=The DNA methylation of [[FOXO3]] and TP53 as a blood biomarker of late-onset asthma. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33298101 |keywords=* Aging * DNA methylation * FOXO3 * Late-onset asthma * TP53 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726856 }} {{medline-entry |title=[[FOXO3]] targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16 increase. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33156570 |keywords=* neurodegenerative disease * neuronal differentiation * neuronal senescence * response mechanisms * temporal dynamics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681055 }} {{medline-entry |title=Astaxanthin as a Putative Geroprotector: Molecular Basis and Focus on Brain Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32635607 |keywords=* FOXO3 * NRF2 * SIRT1 * astaxanthin * geroprotector * longevity * neuroprotection |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7401246 }} {{medline-entry |title=Inflamma-miR-21 Negatively Regulates Myogenesis during Ageing. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32340146 |keywords=* IL6 * IL6R * aging * cachexia * miR-21 * microRNA * muscle * regeneration * sarcopenia |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222422 }} {{medline-entry |title=Variable DNA methylation of aging-related genes is associated with male COPD. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31684967 |mesh-terms=* Adolescent * Adult * Age Factors * Aged * Aged, 80 and over * Aging * Case-Control Studies * CpG Islands * DNA Methylation * Databases, Genetic * Female * Forced Expiratory Volume * Forkhead Transcription Factors * Genetic Predisposition to Disease * Humans * Lung * Male * Middle Aged * Pulmonary Disease, Chronic Obstructive * Risk Assessment * Risk Factors * Severity of Illness Index * Sex Factors * Transcriptome * Vital Capacity * Young Adult |keywords=* Aging * Aging-related genes * COPD * DNA methylation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829949 }} {{medline-entry |title=A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31415568 |mesh-terms=* Animals * Animals, Genetically Modified * Cohort Studies * Disease Models, Animal * Drosophila melanogaster * Feeding Behavior * Female * Gene Knockdown Techniques * Gout * Humans * Insulin * Kidney Calculi * Longevity * Male * Metabolic Networks and Pathways * Middle Aged * NADPH Oxidases * Polymorphism, Single Nucleotide * Purines * Signal Transduction * Urate Oxidase * Uric Acid |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695094 }} ==FOXO4== {{medline-entry |title=[[FOXO4]]-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31959736 |keywords=* FOXO4-DRI * Leydig cell * male late-onset hypogonadism * senescence * senolytics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053614 }} ==FOXP1== {{medline-entry |title=GATA6 regulates aging of human mesenchymal stem/stromal cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33252174 |keywords=* aging * cell signaling * mesenchymal stem cells * reprogramming * transcription factors |full-text-url=https://sci-hub.do/10.1002/stem.3297 }} ==FSHR== {{medline-entry |title=[[FSHR]] ablation induces depression-like behaviors. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32203083 |keywords=* FSH * ROS * aging * antioxidants * depression * metabolism |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468367 }} {{medline-entry |title=Direct actions of gonadotropins beyond the reproductive system and their role in human aging and neoplasia [Bezpośrednie działanie gonadotropin poza układem rozrodczym i ich rola w starzeniu się i nowotworzeniu u człowieka]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31681968 |mesh-terms=* Aging * Female * Gonadotropin-Releasing Hormone * Gonadotropins * Humans * Hypothalamo-Hypophyseal System * Luteinizing Hormone * Male * Receptors, FSH * Receptors, LH |keywords=* aging * folitropin * lutropin * neoplasia |full-text-url=https://sci-hub.do/10.5603/EP.a2019.0034 }} ==FTO== {{medline-entry |title=Decreased expression of m A demethylase [[FTO]] in ovarian aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33221958 |keywords=* Epigenetics * FTO * Ovarian aging * Ovarian reserve * m6A |full-text-url=https://sci-hub.do/10.1007/s00404-020-05895-7 }} ==FYN== {{medline-entry |title=An inhibitor role of Nrf2 in the regulation of myocardial senescence and dysfunction after myocardial infarction. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32781064 |mesh-terms=* Animals * Cardiomyopathies * Cellular Senescence * Echocardiography * Gene Silencing * Male * Mice * Mice, Inbred C57BL * Mice, Knockout * Myocardial Infarction * Myocardium * Myocytes, Cardiac * NF-E2-Related Factor 2 * RNA, Small Interfering * Ventricular Remodeling |keywords=* Cellular senescence * Myocardial infarction * Nrf2 * Oxidative stress |full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118199 }} ==G6PD== {{medline-entry |title=[[G6PD]] overexpression protects from oxidative stress and age-related hearing loss. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33222382 |keywords=* ARHL * NADPH * TrxR * aging * glutathione |full-text-url=https://sci-hub.do/10.1111/acel.13275 }} {{medline-entry |title=The Sickle Effect: The Silent Titan Affecting Glycated Hemoglobin Reliability. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32923278 |keywords=* diabetes * genetics * glycosylated hemoglobin * hba1c * hbas * race * rbc lifespan * sickle cell trait |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486097 }} {{medline-entry |title=DNA damage and synaptic and behavioural disorders in glucose-6-phosphate dehydrogenase-deficient mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31581069 |mesh-terms=* Animals * Brain * DNA Breaks, Double-Stranded * DNA Breaks, Single-Stranded * DNA Damage * Disease Models, Animal * Enzyme Activation * Female * Glucosephosphate Dehydrogenase * Glucosephosphate Dehydrogenase Deficiency * Male * Mental Disorders * Mice * Oxidation-Reduction * Purkinje Cells |keywords=* 8-Oxo-2′-deoxyguanine (8-oxodG) * Aging * Behavioural disorders * Comet * DNA damage * Electrophysiology * Gamma-H2AX (γH2AX) * Glucose-6-phosphate dehydrogenase (G6PD) * Lifespan * Neurodegeneration * Reactive oxygen species (ROS) |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812046 }} ==GAA== {{medline-entry |title=Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32586831 |keywords=* Frataxin * Friedreich's ataxia * Mitochondria * Oxidative stress * Point mutation * Senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406325 }} {{medline-entry |title=Age-Related Changes in Serum Guanidinoacetic Acid in Women. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31647299 |mesh-terms=* Adolescent * Adult * Aged * Aging * Biomarkers * Energy Metabolism * Exercise * Female * Glycine * Humans * Independent Living * Middle Aged * Young Adult |full-text-url=https://sci-hub.do/10.33549/physiolres.934189 }} ==GABARAP== {{medline-entry |title=Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32811819 |mesh-terms=* Adipocytes * Adipogenesis * Adipose Tissue * Adiposity * Aging * Animals * Apoptosis Regulatory Proteins * Autophagy * Fatty Liver * Gene Knockout Techniques * Glucose * HEK293 Cells * Humans * Intracellular Signaling Peptides and Proteins * Lipid Metabolism * Metabolic Diseases * Mice * Mice, Inbred C57BL * Mice, Knockout * Microtubule-Associated Proteins * Nuclear Receptor Coactivator 1 * Nuclear Receptor Coactivator 2 * PPAR gamma |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434891 }} ==GAL== {{medline-entry |title=Overexpression of Pitx1 attenuates the senescence of chondrocytes from osteoarthritis degeneration cartilage-A self-controlled model for studying the etiology and treatment of osteoarthritis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31783149 |keywords=* Osteoarthritis * Pitx1 * Senescence * Sirt1 |full-text-url=https://sci-hub.do/10.1016/j.bone.2019.115177 }} {{medline-entry |title=β-Caryophyllene Reduces DNA Oxidation and the Overexpression of Glial Fibrillary Acidic Protein in the Prefrontal Cortex and Hippocampus of d-Galactose-Induced Aged BALB/c Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31663807 |mesh-terms=* Aging * Animals * Antioxidants * DNA Damage * Disease Models, Animal * Galactose * Glial Fibrillary Acidic Protein * Hippocampus * Male * Mice * Mice, Inbred BALB C * Neuroprotection * Oxidative Stress * Polycyclic Sesquiterpenes * Prefrontal Cortex |keywords=* CB2 receptor agonist * biological aging * cognitive flexibility * phytocannabinoid * β-caryophyllene |full-text-url=https://sci-hub.do/10.1089/jmf.2019.0111 }} ==GAP43== {{medline-entry |title=HDAC inhibition leads to age-dependent opposite regenerative effect upon PTEN deletion in rubrospinal axons after SCI. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32171589 |mesh-terms=* Aging * Animals * Axons * GAP-43 Protein * Gene Deletion * Gene Expression * Histone Deacetylase Inhibitors * Histone Deacetylases * Hydroxamic Acids * Mice, Transgenic * Motor Activity * Nerve Regeneration * PTEN Phosphohydrolase * Recovery of Function * Spinal Cord * Spinal Cord Injuries |keywords=* Aging * Epigenetics * Histone deacetylase * Pten * Regeneration * Spinal cord injury |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.02.006 }} ==GATA4== {{medline-entry |title=Epigenetics and Vascular Senescence-Potential New Therapeutic Targets? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33101015 |keywords=* calcification * cell senescence * epigenetics * inflammation * oxidation stress * vascular aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556287 }} {{medline-entry |title=Prolonged treatment with Y-27632 promotes the senescence of primary human dermal fibroblasts by increasing the expression of IGFBP-5 and transforming them into a CAF-like phenotype. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32843583 |keywords=* IGFBP-5 * Rho kinase inhibitor * Y-27632 * dermal fibroblast * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485707 }} ==GBA== {{medline-entry |title=Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson's disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31703585 |mesh-terms=* Aged * Aging * Female * Glucosylceramidase * Humans * Hydrolases * Lysosomes * Male * Mutation * Parkinson Disease * Risk Factors * Substantia Nigra * alpha-Synuclein |keywords=* Ageing * Ganglioside * Glucocerebrosidase * Glycosphingolipid * Lysosome * Neurodegeneration * Parkinson’s disease |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842240 }} ==GC== {{medline-entry |title=Body Size and Cuticular Hydrocarbons as Larval Age Indicators in the Forensic Blow Fly, Chrysomya albiceps (Diptera: Calliphoridae). |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33274739 |keywords=* Chrysomya albiceps * body size * cuticular hydrocarbon * forensic * larval longevity |full-text-url=https://sci-hub.do/10.1093/jme/tjaa256 }} {{medline-entry |title=Composition of peony petal fatty acids and flavonoids and their effect on Caenorhabditis elegans lifespan. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33092723 |keywords=* Caenorhabditis elegans * Fatty acid * Flavonoid identification and composition * Lifespan extension * Tree peony petal |full-text-url=https://sci-hub.do/10.1016/j.plaphy.2020.06.029 }} {{medline-entry |title=Photo aging and fragmentation of polypropylene food packaging materials in artificial seawater. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33039831 |keywords=* Aging * Antioxidant * Food packaging materials * Microplastics * Polypropylene * seawater |full-text-url=https://sci-hub.do/10.1016/j.watres.2020.116456 }} {{medline-entry |title=Secretory galectin-3 induced by glucocorticoid stress triggers stemness exhaustion of hepatic progenitor cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32989051 |keywords=* AMP-activated kinase (AMPK) * Cell senescence * cell cycle * cellular senescence * galectin * galectin-3 * glycoprotein * liver injury * proliferation * protein interaction * protein-protein interaction * quiescence * stem cells * stemness exhaustion |full-text-url=https://sci-hub.do/10.1074/jbc.RA120.012974 }} {{medline-entry |title=Optimization of Ethanol Detection by Automatic Headspace Method for Cellulose Insulation Aging of Oil-immersed Transformers. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32679756 |keywords=* aging * cellulose insulation * gas chromatography * headspace sampling |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407484 }} {{medline-entry |title=Sensory, olfactometric and chemical characterization of the aroma potential of Garnacha and Tempranillo winemaking grapes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32569964 |mesh-terms=* Fruit * Gas Chromatography-Mass Spectrometry * Hexanols * Norisoprenoids * Odorants * Olfactometry * Principal Component Analysis * Sulfhydryl Compounds * Vitis * Volatile Organic Compounds |keywords=* Aging * Aroma precursors * Glycosides * Lipid-derived aroma * Norisoprenoids * Sensory properties * Terpenols * Volatile phenols |full-text-url=https://sci-hub.do/10.1016/j.foodchem.2020.127207 }} {{medline-entry |title=Accelerated Cognitive Ageing in epilepsy: exploring the effective connectivity between resting-state networks and its relation to cognitive decline. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32529058 |keywords=* Accelerated cognitive ageing * Ageing * Aging * Biomarkers * Clinical research * Cognition * Cognitive decline * Cognitive neuroscience * Effective connectivity * Epilepsy * Fmri * Granger causality * Image processing * Medical imaging * Mental health * Nervous system * Neuroscience * Psychiatry |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283153 }} {{medline-entry |title=Characterization of Jinhua ham aroma profiles in specific to aging time by gas chromatography-ion mobility spectrometry ([[GC]]-IMS). |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32417671 |keywords=* Aging * Electronic-nose * Gas chromatography-ion mobility spectrometry * Jinhua ham * Volatiles |full-text-url=https://sci-hub.do/10.1016/j.meatsci.2020.108178 }} {{medline-entry |title=Quantitative Profiling of Lipid Species in Caenorhabditis elegans with Gas Chromatography-Mass Spectrometry. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32410029 |keywords=* Aging * C. elegans * Fat * Fatty acids * Gas chromatography–mass spectrometry * Lipids * Phospholipids * Solid-phase chromatography * Triglycerides |full-text-url=https://sci-hub.do/10.1007/978-1-0716-0592-9_10 }} {{medline-entry |title=Physicochemical characterization of a polysaccharide from Agrocybe aegirita and its anti-ageing activity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32172871 |mesh-terms=* Aging * Agrocybe * Antioxidants * Carbohydrate Sequence * Cell Line * Chemical Phenomena * G1 Phase Cell Cycle Checkpoints * Humans * Membrane Potential, Mitochondrial * Mitochondria * Polysaccharides |keywords=* Agrocybe aegirita polysaccharide * Anti-ageing * Cell cycle * Mitochondrial membrane potential * Structure |full-text-url=https://sci-hub.do/10.1016/j.carbpol.2020.116056 }} {{medline-entry |title=Structural characteristics, antioxidant properties and antiaging activities of galactan produced by Mentha haplocalyx Briq. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32070549 |mesh-terms=* Aging * Animals * Antioxidants * Biphenyl Compounds * Carbohydrate Conformation * Galactans * Male * Mentha * Mice * Mice, Inbred Strains * Particle Size * Picrates * Surface Properties |keywords=* Anti-aging activity * Antioxidant activity * Mentha haplocalyx Briq * Polysaccharides |full-text-url=https://sci-hub.do/10.1016/j.carbpol.2020.115936 }} {{medline-entry |title=Contribution of Volatile Odorous Terpenoid Compounds to Aged Cognac Spirits Aroma in a Context of Multicomponent Odor Mixtures. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32052967 |keywords=* Cognac * aging aroma * lees * monoterpenes * perceptual synergic effects |full-text-url=https://sci-hub.do/10.1021/acs.jafc.9b06656 }} {{medline-entry |title=Plasma Formate Is Greater in Fetal and Neonatal Rats Compared with Their Mothers. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31912134 |mesh-terms=* Aging * Animals * Animals, Newborn * Female * Fetus * Formates * Liver * Maternal-Fetal Exchange * Mothers * Placenta * Pregnancy * Rats * Rats, Sprague-Dawley |keywords=* fetus * glycine * methionine * mitochondria * one-carbon metabolism * pregnancy * serine * tetrahydrofolate |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198295 }} {{medline-entry |title=Development of a new strategy for studying the aroma potential of winemaking grapes through the accelerated hydrolysis of phenolic and aromatic fractions (PAFs). |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31882095 |keywords=* Aging * Glycosidic precursors * Grape aroma * Grape quality * Hydrolysis * Polyphenols * Wine |full-text-url=https://sci-hub.do/10.1016/j.foodres.2019.108728 }} {{medline-entry |title=Compromised steady-state germinal center activity with age in nonhuman primates. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31840398 |mesh-terms=* Aging * Animals * Antigens, CD * B-Lymphocytes * CD4-Positive T-Lymphocytes * CD8-Positive T-Lymphocytes * Forkhead Transcription Factors * Germinal Center * Granulocytes * Immunity, Humoral * Inflammation * Lymph Nodes * Macaca mulatta * Monocytes |keywords=* B cells * Tfh cells * aging * follicles |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996951 }} {{medline-entry |title=Endogenous Glucocorticoid Signaling in the Regulation of Bone and Marrow Adiposity: Lessons from Metabolism and Cross Talk in Other Tissues. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31749087 |mesh-terms=* Adipose Tissue * Adiposity * Animals * Bone Marrow * Energy Metabolism * Glucocorticoids * Homeostasis * Humans * Liver * Muscle, Skeletal * Receptor Cross-Talk * Receptors, Glucocorticoid * Signal Transduction * Stress, Physiological |keywords=* Adipocyte * Aging * Bone marrow * Corticosterone * Cortisol * Cortisone * Glucocorticoid * Osteoblast |full-text-url=https://sci-hub.do/10.1007/s11914-019-00554-6 }} {{medline-entry |title=4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31639393 |mesh-terms=* Animals * Antineoplastic Agents * Apoptosis * Cell Cycle * Cell Proliferation * Cellular Senescence * DNA Damage * Humans * Mice * Mice, Inbred BALB C * Mice, Nude * Picolinic Acids * Signal Transduction * Stomach Neoplasms * Tumor Cells, Cultured * Xenograft Model Antitumor Assays |keywords=* Cellular senescence * DNA damage * Gastric cancer * N-heterocyclic compound |full-text-url=https://sci-hub.do/10.1016/j.lfs.2019.116973 }} {{medline-entry |title=Relationship Between the Dose Administered, Target Tissue Dose, and Toxicity Level After Acute Oral Exposure to Bifenthrin and Tefluthrin in Young Adult Rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31573616 |mesh-terms=* Administration, Oral * Aging * Animals * Body Temperature * Cerebellum * Cyclopropanes * Dose-Response Relationship, Drug * Hydrocarbons, Fluorinated * Liver * Male * Pyrethrins * Rats * Rats, Wistar * Tissue Distribution * Toxicokinetics |keywords=* acute effects * bifenthrin * body temperature * disposition * rat * tefluthrin |full-text-url=https://sci-hub.do/10.1093/toxsci/kfz204 }} {{medline-entry |title=Sugar Beet Pectin Supplementation Did Not Alter Profiles of Fecal Microbiota and Exhaled Breath in Healthy Young Adults and Healthy Elderly. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31547291 |mesh-terms=* Aged * Beta vulgaris * Breath Tests * Dietary Supplements * Double-Blind Method * Exhalation * Fatty Acids, Volatile * Feces * Female * Gastrointestinal Microbiome * Healthy Volunteers * Humans * Male * Pectins * Volatile Organic Compounds * Young Adult |keywords=* aging * dietary fiber * elderly * exhaled air * microbiota * pectin * young adults |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770243 }} {{medline-entry |title=Identification and analysis of new α- and β-hydroxy ketones related to the formation of 3-methyl-2,4-nonanedione in musts and red wines. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31520920 |mesh-terms=* Alkanes * Diacetyl * Ethanol * Fruit and Vegetable Juices * Gas Chromatography-Mass Spectrometry * Humans * Hydrogen-Ion Concentration * Ketones * Limit of Detection * Solid Phase Microextraction * Stereoisomerism * Time Factors * Wine |keywords=* 3-methyl-2,4-nonanedione * Aroma precursor * Hydroxy ketones * Oxidation * Premature aging * Wine |full-text-url=https://sci-hub.do/10.1016/j.foodchem.2019.125486 }} {{medline-entry |title=Neonatal T Follicular Helper Cells Are Lodged in a Pre-T Follicular Helper Stage Favoring Innate Over Adaptive Germinal Center Responses. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31456798 |mesh-terms=* Adaptive Immunity * Adjuvants, Immunologic * Aging * Animals * Animals, Newborn * Germinal Center * Immunity, Innate * Interleukin-13 * Lymphopoiesis * Mice, Inbred C57BL * T-Lymphocytes, Helper-Inducer * Th2 Cells * Transcriptome |keywords=* T follicular helper cells * adjuvant * neonates * transcriptional profile analysis * vaccines |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700230 }} {{medline-entry |title=Identification of Dialkylpyrazines Off-Flavors in Oak Wood. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31423769 |mesh-terms=* Flavoring Agents * Gas Chromatography-Mass Spectrometry * Odorants * Olfactometry * Pyrazines * Quercus * Wood |keywords=* aroma * barrel aging * dialkylpyrazine * oak wood * off-flavor * wine |full-text-url=https://sci-hub.do/10.1021/acs.jafc.9b03185 }} {{medline-entry |title=Metabolomics Coupled with Transcriptomics Approach Deciphering Age Relevance in Sepsis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31440390 |keywords=* aging * biomarker * metabolomics * sepsis * transcriptomics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675524 }} ==GCA== {{medline-entry |title=Familial aggregation of longevity in giant cell arteritis and polymyalgia rheumatica. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32683496 |keywords=* Giant cell arteritis * Longevity * Mortality * Polymyalgia rheumatica |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591435 }} {{medline-entry |title=Interaction between Alcohol Consumption and Apolipoprotein E (ApoE) Genotype with Cognition in Middle-Aged Men. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32662384 |keywords=* Aging * Alcohol drinking * Apolipoprotein E4 (ApoE) * Cognitive abilities * Male * Middle aged * Risk factors |full-text-url=https://sci-hub.do/10.1017/S1355617720000570 }} ==GCK== {{medline-entry |title=The Impact of Biomarker Screening and Cascade Genetic Testing on the Cost-Effectiveness of MODY Genetic Testing. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31558549 |mesh-terms=* Biomarkers * Child * Cost-Benefit Analysis * Diabetes Mellitus, Type 2 * Female * Genetic Testing * Health Care Costs * Humans * Life Expectancy * Male * Mass Screening * Pedigree * Precision Medicine * Quality-Adjusted Life Years |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868460 }} ==GCLC== {{medline-entry |title=Aerobic exercise training partially reverses the impairment of Nrf2 activation in older humans. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32866619 |keywords=* Aging * Exercise * GCLC * NQO1 * Nrf2 signaling * Redox homeostasis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7704731 }} ==GCLM== {{medline-entry |title=Silencing Bach1 alters aging-related changes in the expression of Nrf2-regulated genes in primary human bronchial epithelial cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31422075 |mesh-terms=* Adult * Aged * Aging * Basic-Leucine Zipper Transcription Factors * Bronchi * Epithelial Cells * Gene Expression * Gene Silencing * Glutamate-Cysteine Ligase * Heme Oxygenase-1 * Humans * Isothiocyanates * Middle Aged * NAD(P)H Dehydrogenase (Quinone) * NF-E2-Related Factor 2 * RNA, Messenger * RNA, Small Interfering * Signal Transduction * Young Adult |keywords=* Aging * Bach1 * Glutamate cysteine ligase * Heme oxygenase * Nrf2 * Sulforaphane |full-text-url=https://sci-hub.do/10.1016/j.abb.2019.108074 }} ==GDF11== {{medline-entry |title=Growth differentiation factor-11 supplementation improves survival and promotes recovery after ischemic stroke in aged mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32365331 |keywords=* GDF11 * White matter integrity * aging * gliosis * stroke |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244081 }} {{medline-entry |title=Anti-Aging Effects of [[GDF11]] on Skin. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32283613 |keywords=* disease * growth factors * regeneration * skin aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177281 }} {{medline-entry |title=Targeted Approach to Distinguish and Determine Absolute Levels of GDF8 and [[GDF11]] in Mouse Serum. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32104967 |keywords=* GDF11 * aging * immunoprecipitation * myostatin/GDF8 * serum * targeted-quantitative proteomics |full-text-url=https://sci-hub.do/10.1002/pmic.201900104 }} {{medline-entry |title=Growth differentiation factor 11 impairs titanium implant healing in the femur and leads to mandibular bone loss. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31983062 |keywords=* aging * alveolar bone loss * dental implants * osseointegration * transforming growth factors |full-text-url=https://sci-hub.do/10.1002/JPER.19-0247 }} {{medline-entry |title=Systemic [[GDF11]] stimulates the secretion of adiponectin and induces a calorie restriction-like phenotype in aged mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31637864 |keywords=* GDF11 * adiponectin * aging * calorie restriction * heterochronic parabiosis * rejuvenation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974718 }} {{medline-entry |title=Circulating factors in young blood as potential therapeutic agents for age-related neurodegenerative and neurovascular diseases. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31400495 |mesh-terms=* Age Factors * Aging * Animals * Blood * Bone Morphogenetic Proteins * Chemokine CCL11 * Enzyme Therapy * Enzymes * Growth Differentiation Factors * Mice * Neurodegenerative Diseases * Parabiosis * Vascular Diseases |keywords=* C-C motif chemokine 11 * Circulating factor * Growth differentiation factor 11 * Neurodegenerative diseases * Neurovascular diseases * Young blood |full-text-url=https://sci-hub.do/10.1016/j.brainresbull.2019.08.004 }} {{medline-entry |title=Effects of Exercise Training on Growth and Differentiation Factor 11 Expression in Aged Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31417428 |keywords=* aging * exercise * growth and differentiation factor 11 * sarcopenia * skeletal muscle |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684741 }} ==GDF15== {{medline-entry |title=Disease-specific plasma levels of mitokines FGF21, [[GDF15]], and Humanin in type II diabetes and Alzheimer's disease in comparison with healthy aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33131010 |keywords=* AD * Aging * FGF21 * GDF15 * Humanin * T2D |full-text-url=https://sci-hub.do/10.1007/s11357-020-00287-w }} {{medline-entry |title=Growth differentiation factor 15 protects against the aging-mediated systemic inflammatory response in humans and mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32691494 |keywords=* T cell * aging * inflammation * mitochondria * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431835 }} {{medline-entry |title=Analysis of Epigenetic Age Predictors in Pain-Related Conditions. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32582603 |keywords=* DNA methylation * aging biomarker * chronic pain * epigenetic aging * epigenetic clock * fibromyalgia * headache * pain sensitivity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296181 }} {{medline-entry |title=[[GDF15]] Plasma Level Is Inversely Associated With Level of Physical Activity and Correlates With Markers of Inflammation and Muscle Weakness. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32477368 |keywords=* GDF15 * healthy aging * inflammation * physical activity * sedentarity * skeletal muscle |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235447 }} {{medline-entry |title=[[GDF15]] is an epithelial-derived biomarker of idiopathic pulmonary fibrosis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31432710 |mesh-terms=* Aged * Alveolar Epithelial Cells * Animals * Bleomycin * Bronchoalveolar Lavage Fluid * Case-Control Studies * Disease Models, Animal * Female * Gene Expression Profiling * Growth Differentiation Factor 15 * Humans * Idiopathic Pulmonary Fibrosis * Lung * Male * Mice * Middle Aged * Respiratory Function Tests * Severity of Illness Index * Survival Analysis * Telomere * Transcriptome |keywords=* MIC-1 * NAG-1 * SASP * aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842909 }} {{medline-entry |title=Senescence-associated tissue microenvironment promotes colon cancer formation through the secretory factor [[GDF15]]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31389184 |mesh-terms=* Aging * Cells, Cultured * Cellular Senescence * Colonic Neoplasms * Fibroblasts * Growth Differentiation Factor 15 * HEK293 Cells * Humans * Phenotype * RNA, Messenger * Tumor Microenvironment |keywords=* GDF15 * colon organoids * colorectal cancer * microenvironment * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826139 }} ==GDF5== {{medline-entry |title=An embryonic CaVβ1 isoform promotes muscle mass maintenance via [[GDF5]] signaling in adult mouse. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31694926 |mesh-terms=* Adult * Aged * Aged, 80 and over * Aging * Animals * Atrophy * Calcium Channels, L-Type * Denervation * Embryo, Mammalian * Exons * Female * Gene Expression Regulation, Developmental * Growth Differentiation Factor 5 * Humans * Male * Mice * Muscles * Neuromuscular Junction * Organ Size * Physical Conditioning, Animal * Protein Isoforms * RNA Splicing * Signal Transduction * Young Adult |full-text-url=https://sci-hub.do/10.1126/scitranslmed.aaw1131 }} ==GDNF== {{medline-entry |title=GFR-α1 Expression in Substantia Nigra Increases Bilaterally Following Unilateral Striatal [[GDNF]] in Aged Rats and Attenuates Nigral Tyrosine Hydroxylase Loss Following 6-OHDA Nigrostriatal Lesion. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31538765 |mesh-terms=* Aging * Animals * Dopamine * Glial Cell Line-Derived Neurotrophic Factor * Glial Cell Line-Derived Neurotrophic Factor Receptors * Neurons * Oxidopamine * Phosphorylation * Rats * Substantia Nigra * Tyrosine 3-Monooxygenase |keywords=* 6-hydroxydopamine * Parkinson’s disease * Substantia nigra * aging * nigrostriatal * tyrosine hydroxylase |full-text-url=https://sci-hub.do/10.1021/acschemneuro.9b00291 }} ==GEM== {{medline-entry |title=The Impact of Geriatric Emergency Management Nurses on the Care of Frail Older Patients in the Emergency Department: a Systematic Review. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32904804 |keywords=* emergency department * geriatric emergency management nurses * geriatrics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7458600 }} ==GFAP== {{medline-entry |title=Immunohistological Detection of Active Satellite Cellsin Rat Dorsal Root Ganglia after Parenteral Administration of Lipopolysaccharide and during Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32990851 |keywords=* aging * dorsal root ganglion * satellite cells * systemic inflammation |full-text-url=https://sci-hub.do/10.1007/s10517-020-04950-2 }} {{medline-entry |title=Transgenic Mice Expressing Human α-Synuclein in Noradrenergic Neurons Develop Locus Ceruleus Pathology and Nonmotor Features of Parkinson's Disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32868457 |keywords=* Parkinson's disease * aging * locus ceruleus * nonmotor * norepinephrine * α-synuclein |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511194 }} {{medline-entry |title=ApoE Genotype-Dependent Response to Antioxidant and Exercise Interventions on Brain Function. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32630431 |keywords=* Alzheimer’s disease * ApoE * aging * antioxidants * cognition * exercise * motor * oxidative stress * vitamin C * vitamin E |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346214 }} {{medline-entry |title=Age-Dependent Heterogeneity of Murine Olfactory Bulb Astrocytes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32581775 |keywords=* Sholl analysis * aging * astrocyte * cell morphology * heterogeneity * olfactory bulb |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296154 }} {{medline-entry |title=Neuroinflammation in Aged Brain: Impact of the Oral Administration of Ellagic Acid Microdispersion. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32455600 |keywords=* CD45 * EA microdispersion (EAm) * GFAP * aging * behavioral skills * ellagic acid (EA) * mice * noradrenaline * oral administration * principal component analysis (PCA) |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279224 }} {{medline-entry |title=Long-term treatment with spermidine increases health span of middle-aged Sprague-Dawley male rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32285289 |keywords=* Autophagy * Behavior * Longevity * Middle-aged rats * Neuroinflammation * Spermidine |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287009 }} {{medline-entry |title=Meta-analysis of human prefrontal cortex reveals activation of [[GFAP]] and decline of synaptic transmission in the aging brain. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32138778 |keywords=* Aging * Meta-analysis * Prefrontal cortex * Sex-specific * Transcriptome |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059712 }} {{medline-entry |title=Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA-mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32030764 |keywords=* BCAA * ER stress * aging * autophagy * lipogenesis * mTORC1 |full-text-url=https://sci-hub.do/10.1111/jnc.14979 }} {{medline-entry |title=Long-lived mice with reduced growth hormone signaling have a constitutive upregulation of hepatic chaperone-mediated autophagy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32013718 |keywords=* Aging * chaperone-mediated autophagy * endocrine control of autophagy * endocrine signaling * growth hormone |full-text-url=https://sci-hub.do/10.1080/15548627.2020.1725378 }} {{medline-entry |title=Lipopolysaccharide exposure during late embryogenesis triggers and drives Alzheimer-like behavioral and neuropathological changes in CD-1 mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31997558 |keywords=* Alzheimer's disease * aging * lipopolysaccharide * memory * mice |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066339 }} {{medline-entry |title=Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31907998 |mesh-terms=* Alzheimer Disease * Amyloid beta-Peptides * Animals * Astrocytes * Gene Knock-In Techniques * Longevity * Mice * Mice, Knockout * Mice, Obese * Microglia * Peptide Fragments |keywords=* Alzheimer's disease * astrocytes * diabetes * lifespan * microglia * obesity |full-text-url=https://sci-hub.do/10.1096/fj.201901028RR }} {{medline-entry |title=Selective brain neuronal and glial losses without changes in [[GFAP]] immunoreactivity: Young versus mature adult Wistar rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31404554 |mesh-terms=* Aging * Animals * Brain * Glial Fibrillary Acidic Protein * Male * Neuroglia * Neurons * Rats * Rats, Wistar |keywords=* Ageing * Astrocytes * GFAP * Glia * Neurons |full-text-url=https://sci-hub.do/10.1016/j.mad.2019.111128 }} ==GGCT== {{medline-entry |title=Blockade of γ-Glutamylcyclotransferase Enhances Docetaxel Growth Inhibition of Prostate Cancer Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31519583 |mesh-terms=* Antineoplastic Agents * Apoptosis * Cell Line, Tumor * Cell Proliferation * Cellular Senescence * Docetaxel * Enzyme Inhibitors * Gene Expression * Humans * Immunohistochemistry * Male * Prostatic Neoplasms * RNA, Small Interfering * gamma-Glutamylcyclotransferase |keywords=* docetaxel * pro-GA * prostate cancer cells * senescence * γ-glutamylcyclotransferase |full-text-url=https://sci-hub.do/10.21873/anticanres.13666 }} ==GHR== {{medline-entry |title=Tissue-Specific [[GHR]] Knockout Mice: An Updated Review. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33162937 |keywords=* aging * growth hormone * longevity * metabolism * mice |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7581730 }} ==GHRH== {{medline-entry |title=Physiological and metabolic features of mice with CRISPR/Cas9-mediated loss-of-function in growth hormone-releasing hormone. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32422607 |keywords=* CRISPR * GHRH * aging * lifespan * metabolism |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288930 }} {{medline-entry |title=Transcriptomic and metabolomic profiling of long-lived growth hormone releasing hormone knock-out mice: evidence for altered mitochondrial function and amino acid metabolism. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32091406 |keywords=* aging * growth hormone * metabolite * mouse * transcriptomics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066919 }} ==GIP== {{medline-entry |title=Absence of [[GIP]] secretion alleviates age-related obesity and insulin resistance. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31977316 |mesh-terms=* Adiponectin * Adipose Tissue * Age Factors * Animals * Diet * Diet, High-Fat * Enteroendocrine Cells * Gastric Inhibitory Polypeptide * Gene Expression * Glucose Tolerance Test * Insulin * Insulin Resistance * Leptin * Male * Mice, Inbred C57BL * Mice, Knockout * Mice, Transgenic * Obesity |keywords=* GIP * aging * incretin * obesity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040458 }} ==GIT2== {{medline-entry |title=Multidimensional informatic deconvolution defines gender-specific roles of hypothalamic [[GIT2]] in aging trajectories. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31574270 |mesh-terms=* Aging * Animals * Cluster Analysis * Computational Biology * Female * GTPase-Activating Proteins * Hypothalamus * Longevity * Male * Mice * Mice, Inbred C57BL * RNA * Sex Characteristics * Signal Transduction * Transcriptome |keywords=* Aging * Female * GIT2 * Hypothalamus * Longevity |full-text-url=https://sci-hub.do/10.1016/j.mad.2019.111150 }} ==GJC2== {{medline-entry |title=Zebrafish brain RNA sequencing reveals that cell adhesion molecules are critical in brain aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32629311 |keywords=* Brain aging * Cell adhesion molecules * RNA sequencing * Zebrafish |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.04.017 }} ==GK== {{medline-entry |title=Progression of diabetic kidney disease in T2DN rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31566426 |mesh-terms=* Aging * Albuminuria * Animals * Blood Glucose * Diabetes Mellitus, Type 2 * Diabetic Nephropathies * Disease Progression * Hypertrophy * Kidney Glomerulus * Male * Membrane Proteins * Organ Size * Polyuria * Rats * Rats, Wistar * Renin-Angiotensin System * Water-Electrolyte Imbalance |keywords=* diabetic glomerular disease * diabetic nephropathy * podocyte pathology * renin-angiotensin-aldosterone system * scanning ion microscopy * type 2 diabetic nephropathy |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960784 }} ==GNAQ== {{medline-entry |title=[[GNAQ]] expression initiated in multipotent neural crest cells drives aggressive melanoma of the central nervous system. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31680437 |mesh-terms=* Aging * Animals * Central Nervous System Neoplasms * Disease Models, Animal * Disease Progression * Embryonic Development * Female * GTP-Binding Protein alpha Subunits, Gq-G11 * Male * Melanocytes * Melanoma * Meningeal Neoplasms * Mice, Transgenic * Multipotent Stem Cells * Mutation * Neoplasm Invasiveness * Neural Crest * Nevus * Skin Neoplasms * Uveal Neoplasms |keywords=* GNAQ * Plp1 * blue nevus * leptomeningeal melanocytoma * uveal melanoma |full-text-url=https://sci-hub.do/10.1111/pcmr.12843 }} ==GNE== {{medline-entry |title=Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2 mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33300446 |keywords=* Aging * Dnm1l/DRP1 * SQSTM1/p62 * knockin mice * macroautophagy * mitochondria dysfunction * mitochondrial fission * mitophagy * parkinson disease * ubiquitination |full-text-url=https://sci-hub.do/10.1080/15548627.2020.1850008 }} ==GPC1== {{medline-entry |title=Decreased expression of [[GPC1]] in human skin keratinocytes and epidermis during ageing. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31430521 |mesh-terms=* Adult * Aged * Aged, 80 and over * Aging * Cell Proliferation * Cells, Cultured * Epidermis * Female * Fibroblast Growth Factor 2 * Gene Expression Regulation * Glypicans * Humans * Keratinocytes * Middle Aged * RNA, Messenger * Signal Transduction * Skin * Young Adult |keywords=* Ageing * Epidermis * Glypican 1 * Human skin * Keratinocytes |full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110693 }} ==GPI== {{medline-entry |title=Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32646997 |mesh-terms=* Aging * Animals * Blood Circulation * Brain * Cognition * Cognitive Dysfunction * Glycosylphosphatidylinositols * Liver * Mice * Neurogenesis * Phospholipase D * Physical Conditioning, Animal * Regeneration * Signal Transduction |full-text-url=https://sci-hub.do/10.1126/science.aaw2622 }} ==GPR6== {{medline-entry |title=Accelerated Epigenetic Aging and Methylation Disruptions Occur in Human Immunodeficiency Virus Infection Prior to Antiretroviral Therapy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32959881 |keywords=* HIV * aging * epigenetics * methylation |full-text-url=https://sci-hub.do/10.1093/infdis/jiaa599 }} ==GPT== {{medline-entry |title=Brain Structural-Behavioral Correlates Underlying Grooved Pegboard Test Performance Across Lifespan. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32631206 |keywords=* aging * gray matter * visuomotor function * white matter |full-text-url=https://sci-hub.do/10.1080/00222895.2020.1787320 }} ==GPX1== {{medline-entry |title=Glutathione peroxidase-1 overexpression reduces oxidative stress, and improves pathology and proteome remodeling in the kidneys of old mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32400101 |keywords=* glutathione peroxidase-1 * kidney aging * mitochondria * proteomics * reactive oxygen species |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294784 }} ==GPX3== {{medline-entry |title=Long noncoding RNA glutathione peroxidase 3-antisense inhibits lens epithelial cell apoptosis by upregulating glutathione peroxidase 3 expression in age-related cataract. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31814699 |mesh-terms=* Aging * Anterior Capsule of the Lens * Apoptosis * Cataract * Cell Line * Cell Nucleus * Epithelial Cells * Glutathione Peroxidase * Humans * Hydrogen Peroxide * Lens, Crystalline * RNA, Long Noncoding * Up-Regulation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857780 }} ==GPX4== {{medline-entry |title=l-carnitine supplementation during in vitro culture regulates oxidative stress in embryos from bovine aged oocytes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31837632 |mesh-terms=* Animals * Carnitine * Cattle * Culture Media * Embryo Culture Techniques * Female * Fertilization in Vitro * In Vitro Oocyte Maturation Techniques * Oocytes * Oxidative Stress |keywords=* Bovine * Embryo development * Oocyte aging * l-carnitine |full-text-url=https://sci-hub.do/10.1016/j.theriogenology.2019.11.036 }} {{medline-entry |title=Dietary Selenium Supplementation Ameliorates Female Reproductive Efficiency in Aging Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31835711 |keywords=* GPX4 * Gpx1 * Gpx3 * Selenof * apoptosis * embryo * follicle development * ovarian aging * selenium * selenoprotein |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969897 }} ==GREM1== {{medline-entry |title=[[GREM1]] inhibits osteogenic differentiation, senescence and BMP transcription of adipose-derived stem cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32151168 |keywords=* BMP * GREM1 * adipose-derived stem cells (ADSCs) * osteogenic differentiation * senescence |full-text-url=https://sci-hub.do/10.1080/03008207.2020.1736054 }} ==GREM2== {{medline-entry |title=Increase of gremlin 2 with age in human adipose-derived stromal/stem cells and its inhibitory effect on adipogenesis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31709279 |keywords=* Adipogenic differentiation * Adipose-derived stromal/stem stem cells * Aging * DAPI, 4′,6-diamidino-2-phenylindole * FGF, fibroblast growth factor * GREM2 * GREM2 knockdown * HE, hematoxylin eosin * Individual differences * PBS, phosphate buffered Solution * PFA, paraformaldehyde * TGF-β, transforming growth factor beta |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831850 }} ==GRID1== {{medline-entry |title=Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32109663 |keywords=* GWAS * HDL-C metabolism * Healthy aging * Longevity * Longitudinal HDL-C change |full-text-url=https://sci-hub.do/10.1016/j.atherosclerosis.2020.02.005 }} ==GRIK2== {{medline-entry |title=Senescence of Normal Human Fibroblasts Relates to the Expression of Ionotropic Glutamate Receptor GluR6/Grik2. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33099472 |keywords=* GluR6 * Grik2 * Senescence * cancer * glutamate receptor * normal fibroblasts |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675648 }} ==GRK2== {{medline-entry |title=G protein-coupled receptor kinase 2 modifies the ability of Caenorhabditis elegans to survive oxidative stress. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33064264 |keywords=* Aging * Caenorhabditis elegans (C. elegans) * G protein coupled receptor kinase (GRK) * Oxidative stress * Resistance * Stress response |full-text-url=https://sci-hub.do/10.1007/s12192-020-01168-z }} {{medline-entry |title=G protein coupled receptor kinases modulate Caenorhabditis elegans reactions to heat stresses. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32768194 |keywords=* Aging * Biological control * Caenorhabditis elegans (C. elegans) * G protein coupled receptor (GPCR) * G protein coupled receptor kinase (GRK) * Heat stress * Resistance * Stress response |full-text-url=https://sci-hub.do/10.1016/j.bbrc.2020.07.121 }} {{medline-entry |title=Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32216616 |mesh-terms=* Aging * Animals * Female * G Protein-Coupled Inwardly-Rectifying Potassium Channels * Heart * Heart Diseases * Homeostasis * Male * Mice * Mutation * Myocardium * Nitric Oxide |keywords=* S-nitrosylation * cardiac hypertrophy * heart disease |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346533 }} ==GRM3== {{medline-entry |title=Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32203495 |mesh-terms=* Adolescent * Adult * Aged * Aged, 80 and over * Aging * Bipolar Disorder * Dentate Gyrus * Depressive Disorder, Major * Female * Gene Expression Profiling * Genetic Predisposition to Disease * Genome-Wide Association Study * Humans * Male * Middle Aged * Neurons * Quantitative Trait Loci * Schizophrenia * Transcriptome * Young Adult |full-text-url=https://sci-hub.do/10.1038/s41593-020-0604-z }} ==GRN== {{medline-entry |title=Stressful development: Integrating endoderm development, stress, and longevity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33307045 |keywords=* Caenorhabditis elegans * Embryonic development * Epigenetics inheritance * Innate immunity * Longevity * Pleiotropy * Stress |full-text-url=https://sci-hub.do/10.1016/j.ydbio.2020.12.002 }} {{medline-entry |title=A Scoping Review of the Evidence About the Nurses Improving Care for Healthsystem Elders (NICHE) Program. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31681955 |keywords=* Aging * Geriatric nursing * Health care professionals * Intervention * Quality improvement |full-text-url=https://sci-hub.do/10.1093/geront/gnz150 }} ==GSC== {{medline-entry |title=[i]mastermind[/i] regulates niche ageing independently of the [i]Notch[/i] pathway in the [i]Drosophila[/i] ovary. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31744422 |mesh-terms=* Aging * Animals * Cellular Senescence * Drosophila Proteins * Drosophila melanogaster * Female * Germ Cells * Nuclear Proteins * Ovary * Receptors, Notch * Signal Transduction * Stem Cell Niche * Transcriptome |keywords=* DE-cadherin * Drosophila oogenesis * Hedgehog * mastermind * niche ageing * reactive oxygen species |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893403 }} ==GSTM1== {{medline-entry |title=The effects of everyday-life exposure to polycyclic aromatic hydrocarbons on biological age indicators. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33272294 |keywords=* Biological aging * DNA adduct * Mitochondrial DNA copy number * Polycyclic aromatic hydrocarbon * Structural equation modelling * Telomere length |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713168 }} ==GSTM2== {{medline-entry |title=Small Extracellular Vesicles Have GST Activity and Ameliorate Senescence-Related Tissue Damage. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32574561 |keywords=* 4-HNE * EV * GSH * GST * ROS * SASP * aging * extracellular vesicles * glutathione metabolism * glutathione-S-transferase * lipid peroxidation * rejuvenation * senescence * senescence-associated secretory phenotype |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342013 }} ==GUK1== {{medline-entry |title=Characterization of the impact of GMP/GDP synthesis inhibition on replicative lifespan extension in yeast. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32232569 |keywords=* Aging * GDP * GMP * Mycophenolic acid * Proteasome * Replicative lifespan * Yeast |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367712 }} ==GZMK== {{medline-entry |title=Comprehensive Profiling of an Aging Immune System Reveals Clonal [[GZMK]] CD8 T Cells as Conserved Hallmark of Inflammaging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33271118 |keywords=* Aging * CD8 T cells * CITE-seq * granzyme K * immune system * inflammaging * single-cell ATAC-sequencing * single-cell BCR-sequencing * single-cell RNA-sequencing * single-cell TCR-sequencing |full-text-url=https://sci-hub.do/10.1016/j.immuni.2020.11.005 }} ==H2AX== {{medline-entry |title=Evaluation of Gamma[[H2AX]] in Buccal Cells as a Molecular Biomarker of DNA Damage in Alzheimer's Disease in the AIBL Study of Ageing. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32781776 |keywords=* Alzheimer’s disease * DNA damage * mild cognitive impairment * senescence * γH2AX |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459751 }} {{medline-entry |title=Cisplatin-induced peripheral neuropathy is associated to neuronal senescence-like response. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32597980 |keywords=* cisplatin * neuropathy * neurotoxicity * p21 * senescence |full-text-url=https://sci-hub.do/10.1093/neuonc/noaa151 }} {{medline-entry |title=Guanine Deaminase Stimulates Ultraviolet-induced Keratinocyte Senescence in Seborrhoeic Keratosis via Guanine Metabolites. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32215662 |keywords=* DNA damage * UV-induced keratinocyte senescence * guanine deaminase * reactive oxygen species * uric acid * seborrhoeic keratosis |full-text-url=https://sci-hub.do/10.2340/00015555-3473 }} {{medline-entry |title=Do BRCA1 and BRCA2 gene mutation carriers have a reduced ovarian reserve? Protocol for a prospective observational study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31772111 |mesh-terms=* Adolescent * Adult * Aging * BRCA1 Protein * BRCA2 Protein * Female * Germ-Line Mutation * Heterozygote * Humans * Immunohistochemistry * Middle Aged * Observational Studies as Topic * Ovarian Follicle * Ovarian Reserve * Prospective Studies * Research Design * Young Adult |keywords=* BRCA * DNA repair * fertility * follicle * germline mutation * oocyte |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887091 }} {{medline-entry |title=Slower rates of accumulation of DNA damage in leukocytes correlate with longer lifespans across several species of birds and mammals. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31730540 |mesh-terms=* Animals * Birds * Bottle-Nosed Dolphin * Cross-Sectional Studies * DNA Damage * Goats * Leukocytes * Longevity * Reindeer * Turtles * Vertebrates |keywords=* DNA damage * lifespan * short telomeres * species |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874430 }} {{medline-entry |title=Phosphoproteomic analysis reveals plant DNA damage signalling pathways with a functional role for histone [[H2AX]] phosphorylation in plant growth under genotoxic stress. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31410901 |mesh-terms=* ATP-Binding Cassette Transporters * Aging * Arabidopsis * Arabidopsis Proteins * Cells, Cultured * DNA Damage * DNA Repair * Gene Expression Regulation, Plant * Gene Ontology * Germination * Histones * Mass Spectrometry * Phosphorylation * Proteome * Seeds * Serine * Signal Transduction * Stress, Physiological * X-Rays |keywords=* ATAXIA TELANGIECTASIA MUTATED (ATM) * DNA damage response * DNA repair * phosphorylation * seed |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900162 }} ==HBM== {{medline-entry |title=The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31553309 |mesh-terms=* Adipose Tissue * Adiposity * Animals * Bone Density * Bone Marrow * Dietary Fats * Dietary Supplements * Disease Models, Animal * Fatty Acids, Omega-3 * Female * Femur * Mice * Osteoporosis * X-Ray Microtomography |keywords=* SAMP8 mouse * aging * fish oil * marrow adipose tissue * osteoporosis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781972 }} ==HBP1== {{medline-entry |title=Suppression of p38/[[HBP1]] pathway alleviates hyperosmotic stress-induced senescent progression of chondrocyte senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32549582 |mesh-terms=* Cellular Senescence * Chondrocytes * Disease Progression * High Mobility Group Proteins * Humans * Osteoarthritis * Repressor Proteins * Up-Regulation * p38 Mitogen-Activated Protein Kinases |keywords=* HBP1 * chondrocyte * osmolality stress * p38 * senescence |full-text-url=https://sci-hub.do/10.23812/20-63-A-6 }} ==HCN1== {{medline-entry |title=Protein expression changes of [[HCN1]] and HCN2 in hippocampal subregions of gerbils during the normal aging process. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32128096 |keywords=* Aging * Dentate gyrus * Granule cells * HCN channel * Hippocampus proper * Pyramidal cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038419 }} ==HDAC1== {{medline-entry |title=[[HDAC1]] modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32424276 |mesh-terms=* Acetylation * Aging * Alzheimer Disease * Animals * Astrocytes * Base Sequence * Benzophenones * Brain * Cognition * Cognition Disorders * DNA Damage * DNA Glycosylases * Down-Regulation * Gene Ontology * Guanine * Histone Deacetylase 1 * Memory * Mice, Inbred C57BL * Mice, Knockout * Neurons * Oxidative Stress * Promoter Regions, Genetic |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235043 }} ==HDAC10== {{medline-entry |title=Middle-aged female rats lack changes in histone H3 acetylation in the anterior hypothalamus observed in young females on the day of a luteinizing hormone surge. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31434815 |mesh-terms=* Acetylation * Age Factors * Animals * Estradiol * Female * Histones * Hypothalamus, Anterior * Luteinizing Hormone * Rats * Rats, Sprague-Dawley |keywords=* Histone acetylation * LH * aging * histone deacetylases * hypothalamus |full-text-url=https://sci-hub.do/10.5582/bst.2019.01162 }} ==HDAC2== {{medline-entry |title=EEF1A1 deacetylation enables transcriptional activation of remyelination. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32647127 |mesh-terms=* Acetylation * Aging * Animals * Cell Dedifferentiation * Cell Nucleus * Histone Deacetylase 1 * Histone Deacetylase 2 * Lysine Acetyltransferase 5 * Mice * Models, Biological * Oligodendroglia * Peptide Elongation Factor 1 * Peripheral Nervous System * Recovery of Function * Remyelination * SOXE Transcription Factors * STAT3 Transcription Factor * Schwann Cells * Theophylline * Trans-Activators * Transcriptional Activation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347577 }} ==HDAC3== {{medline-entry |title=Histone deacetylase-3: Friend and foe of the brain. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32486848 |keywords=* Histone deacetylases * aging * histone deacetylase-3 * learning and memory * neurodegenerative diseases * neurodevelopment |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400723 }} {{medline-entry |title=Loss of [[HDAC3]] contributes to meiotic defects in aged oocytes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31498540 |mesh-terms=* Animals * Cells, Cultured * Cellular Senescence * Female * Histone Deacetylases * Meiosis * Mice * Mice, Inbred ICR * Oocytes |keywords=* HDACs * aneuploidy * maternal aging * oocyte quality * reproduction |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826132 }} ==HDAC4== {{medline-entry |title=The posttranslational modification of [[HDAC4]] in cell biology: Mechanisms and potential targets. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31588631 |keywords=* HDAC4 * cell senescence * cellular apoptosis and autophagy * glucose metabolism * inflammation and pathology * proliferation and differentiation |full-text-url=https://sci-hub.do/10.1002/jcb.29365 }} ==HDAC6== {{medline-entry |title=Inhibition of [[HDAC6]] Attenuates Diabetes-Induced Retinal Redox Imbalance and Microangiopathy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32660051 |keywords=* HDAC6 * diabetic retinopathy * oxidative stress * retinal endothelial cell senescence * retinal endothelial cells * tubastatin A |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402090 }} ==HDC== {{medline-entry |title=Induced pluripotency and spontaneous reversal of cellular aging in supercentenarian donor cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32115145 |mesh-terms=* Adult * Aged, 80 and over * Cell Differentiation * Cell Line * Cellular Reprogramming * Cellular Senescence * Child * Clone Cells * Gene Expression Regulation * Humans * Induced Pluripotent Stem Cells * Mesenchymal Stem Cells * Telomere Homeostasis * Tissue Donors * Transcriptome |keywords=* Aging * Longevity * Reprogramming * Supercentenarian * Telomere * iPSC |full-text-url=https://sci-hub.do/10.1016/j.bbrc.2020.02.092 }} ==HES1== {{medline-entry |title=A Single-Cell Transcriptomic Atlas of Human Skin Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33238152 |keywords=* HES1 * KLF6 * aging * fibroblast * keratinocyte * quercetin * senescence * single-cell RNA sequencing * skin |full-text-url=https://sci-hub.do/10.1016/j.devcel.2020.11.002 }} ==HFE== {{medline-entry |title=Polyphenol Characterization and Skin-Preserving Properties of Hydroalcoholic Flower Extract from [i]Himantoglossum robertianum[/i] (Orchidaceae). |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31739534 |keywords=* Himantoglossum robertianum * antioxidants * collagenase * elastase * flavonoids * keratinocytes * skin aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918203 }} ==HGD== {{medline-entry |title=High-glucose diets induce mitochondrial dysfunction in Caenorhabditis elegans. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31846489 |mesh-terms=* Animals * Caenorhabditis elegans * Diet * Gene Expression Regulation * Glucose * Longevity * Mitochondria * Mitophagy |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917275 }} ==HGF== {{medline-entry |title=Age-related changes in the immunomodulatory effects of human dental pulp derived mesenchymal stem cells on the CD4 T cell subsets. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33223447 |keywords=* Aging * CD4 T cell * Dental pulp * Immunomodulation * Mesenchymal stem cell |full-text-url=https://sci-hub.do/10.1016/j.cyto.2020.155367 }} {{medline-entry |title=Hepatocyte growth factor ([[HGF]]) and stem cell factor (SCF) maintained the stemness of human bone marrow mesenchymal stem cells (hBMSCs) during long-term expansion by preserving mitochondrial function via the PI3K/AKT, ERK1/2, and STAT3 signaling pathways. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32736659 |keywords=* Hepatocyte growth factor * Mitochondrial function * Osteogenic differentiation * Senescence * Stem cell factor * Stem cells from human exfoliated deciduous teeth * Stemness |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393921 }} {{medline-entry |title=Phenytoin sodium-ameliorated gingival fibroblast aging is associated with autophagy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32281104 |keywords=* aging * autophagy * gingival fibroblast * phenytoin sodium |full-text-url=https://sci-hub.do/10.1111/jre.12750 }} {{medline-entry |title=Impaired integrin α /β -mediated hepatocyte growth factor release by stellate cells of the aged liver. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32157808 |keywords=* aging * hepatic stellate cells * integrins * laminins * mechanobiology |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189994 }} ==HGS== {{medline-entry |title=Handgrip strength asymmetry is associated with future falls in older Americans. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33247424 |keywords=* Aging * Functional laterality * Geriatric assessment * Geriatrics * Muscle strength dynamometer |full-text-url=https://sci-hub.do/10.1007/s40520-020-01757-z }} {{medline-entry |title=Examining Additional Aspects of Muscle Function with a Digital Handgrip Dynamometer and Accelerometer in Older Adults: A Pilot Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33142897 |keywords=* aging * geriatric assessment * muscle strength * muscle weakness * physical functional performance |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709634 }} {{medline-entry |title=The Relationship between Muscular Strength and Depression in Older Adults with Chronic Disease Comorbidity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32962093 |keywords=* aging * depression * disease comorbidities * muscular strength |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558624 }} {{medline-entry |title=Handgrip Strength in the Korean Population: Normative Data and Cutoff Values. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32743310 |keywords=* Aging * Hand strength * Muscle strength * Nutrition surveys * Sarcopenia |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7370763 }} {{medline-entry |title=Handgrip Strength Asymmetry and Weakness Are Associated with Lower Cognitive Function: A Panel Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32473060 |keywords=* aging * functional laterality * geriatric assessment * geriatrics * muscle strength dynamometer |full-text-url=https://sci-hub.do/10.1111/jgs.16556 }} {{medline-entry |title=Handgrip Strength Asymmetry and Weakness are Differentially Associated with Functional Limitations in Older Americans. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32384713 |mesh-terms=* Aged * Aged, 80 and over * Female * Geriatric Assessment * Hand Strength * Humans * Male * Middle Aged * Muscle Strength * Muscle Strength Dynamometer * Muscle Weakness * Odds Ratio * United States |keywords=* aging * geriatrics * muscle strength * muscle strength dynamometer * nutrition surveys |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246814 }} {{medline-entry |title=Absolute and Body Mass Index Normalized Handgrip Strength Percentiles by Gender, Ethnicity, and Hand Dominance in Americans. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31930203 |keywords=* aging * epidemiology * hand strength * human development * muscle weakness |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954001 }} {{medline-entry |title=Hand grip strength variability during serial testing as an entropic biomarker of aging: a Poincaré plot analysis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31931730 |mesh-terms=* Aged * Aged, 80 and over * Aging * Biomarkers * Cross-Sectional Studies * Entropy * Female * Hand Strength * Heart Rate * Humans * Male |keywords=* Aging * Entropy * Hand grip strength * Nonlinear dynamics * Poincaré plot * Time series |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958685 }} {{medline-entry |title=Physical Activity and Fitness in White- and Blue-Collar Retired Men. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31849269 |mesh-terms=* Aged * Aged, 80 and over * Aging * Body Mass Index * Exercise * Geriatric Assessment * Humans * Longitudinal Studies * Male * Men's Health * Occupations * Physical Fitness * Poland * Retirement * Social Class * Surveys and Questionnaires * Task Performance and Analysis |keywords=* Retirement * occupation * old men * physical activity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920597 }} {{medline-entry |title=Association between Hand Grip Strength and Self-Rated Health in Middle- and Old-Aged Korean Citizens. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31842533 |keywords=* Hand Grip Strength * Korean Longitudinal Study of Aging * Self-Rated Health |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987025 }} {{medline-entry |title=Weakness May Have a Causal Association With Early Mortality in Older Americans: A Matched Cohort Analysis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31786197 |keywords=* Aging * Epidemiology * Geriatrics * hand strength * muscle strength * sarcopenia |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186143 }} {{medline-entry |title=Associations Between Dietary Patterns and Handgrip Strength: The Korea National Health and Nutrition Examination Survey 2014-2016. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31743070 |keywords=* Dietary patterns * Korea National Health and Nutrition Examination Survey * aging * diet * handgrip strength |full-text-url=https://sci-hub.do/10.1080/07315724.2019.1691955 }} {{medline-entry |title=Effect of relative handgrip strength on cardiovascular disease among Korean adults aged 45 years and older: Results from the Korean Longitudinal Study of Aging (2006-2016). |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31574451 |mesh-terms=* Adult * Aged * Aged, 80 and over * Aging * Cardiovascular Diseases * Female * Hand Strength * Humans * Longitudinal Studies * Male * Middle Aged * Muscle Strength * Muscle, Skeletal * Republic of Korea * Risk Factors |keywords=* Cardiovascular disease * KLoSA * Relative handgrip strength |full-text-url=https://sci-hub.do/10.1016/j.archger.2019.103937 }} {{medline-entry |title=Weakness and cognitive impairment are independently and jointly associated with functional decline in aging Americans. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31520335 |mesh-terms=* Activities of Daily Living * Aged * Aging * Cognitive Dysfunction * Geriatric Assessment * Hand Strength * Humans * Middle Aged |keywords=* Dementia * Epidemiology * Geriatrics * Muscle strength * Nervous system |full-text-url=https://sci-hub.do/10.1007/s40520-019-01351-y }} {{medline-entry |title=Association of phase angle with sarcopenia and its components in physically active older women. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31463928 |mesh-terms=* Aged * Cross-Sectional Studies * Electric Impedance * Female * Hand Strength * Humans * Muscle Strength * Sarcopenia * Walking Speed |keywords=* Aging * Bioimpedance * Muscle function * Muscle mass |full-text-url=https://sci-hub.do/10.1007/s40520-019-01325-0 }} ==HLA-DRB1== {{medline-entry |title=The pathophysiology of polymyalgia rheumatica, small pieces of a big puzzle. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32942037 |keywords=* Aging * B cell * HLA-DR * Interleukin-6 * Polymyalgia rheumatica * T cell |full-text-url=https://sci-hub.do/10.1016/j.autrev.2020.102670 }} ==HMGA1== {{medline-entry |title=Characterization of [i][[HMGA1]]P6[/i] transgenic mouse embryonic fibroblasts. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32787507 |keywords=* CeRNA * HMGA1 * HMGA1P6 * pseudogenes * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513866 }} ==HMGA2== {{medline-entry |title=4D Genome Rewiring during Oncogene-Induced and Replicative Senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32220303 |mesh-terms=* Cells, Cultured * Cellular Senescence * Chromatin Assembly and Disassembly * DNA (Cytosine-5-)-Methyltransferase 1 * DNA Methylation * Fibroblasts * Genome, Human * Heterochromatin * Humans * In Situ Hybridization, Fluorescence * Oncogenes |keywords=* 3D genome architecture * DNMT1 * Hi-C * chromatin compartments * gene regulation * oncogene-induced senescence * replicative senescence * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7208559 }} {{medline-entry |title=The protective effects of [[HMGA2]] in the senescence process of bone marrow-derived mesenchymal stromal cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32068957 |keywords=* bone marrow derived mesenchymal stromal cells (MSCs) * high-mobility group AT-hook 2 (HMGA2) * regulator of G protein signaling 2 (Rgs2) * senescence |full-text-url=https://sci-hub.do/10.1002/term.3023 }} ==HMGB1== {{medline-entry |title=Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31633821 |mesh-terms=* Adult * Aged * Aged, 80 and over * Aging * Atrophy * Cells, Cultured * Cellular Senescence * Cyclin-Dependent Kinase Inhibitor p16 * Epidermis * Female * Humans * Male * Melanocytes * Middle Aged * Paracrine Communication * Reactive Oxygen Species * Receptors, CXCR4 * Skin * Telomere * Young Adult |keywords=* SASP * melanocytes * senescence * skin ageing * telomeres |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885734 }} ==HMGCR== {{medline-entry |title=Cholesterol Homeostasis: An In Silico Investigation into How Aging Disrupts Its Key Hepatic Regulatory Mechanisms. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33007859 |keywords=* aging * cholesterol biosynthesis * mathematical model * reactive oxygen species * systems biology |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599957 }} {{medline-entry |title=Artesunate inhibits the mevalonate pathway and promotes glioma cell senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31746143 |keywords=* artesunate * distant seeding * glioma * mevalonate pathway * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933330 }} ==HOXD8== {{medline-entry |title=Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32849838 |keywords=* Hoxd8 * cellular senescence * mouse embryonic fibroblasts * senescence-associated secretory phenotype * single-cell RNA sequencing * transcriptomic heterogeneity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431633 }} ==HP== {{medline-entry |title=A narrative review of highly processed food addiction across the lifespan. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33127423 |keywords=* Adolescence * Adulthood * Childhood * Food addiction * Infancy * Lifespan * Prenatal |full-text-url=https://sci-hub.do/10.1016/j.pnpbp.2020.110152 }} {{medline-entry |title=Beta Human Papillomavirus 8E6 Attenuates LATS Phosphorylation after Failed Cytokinesis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32238586 |mesh-terms=* Apoptosis * Cell Cycle Proteins * Cell Line, Tumor * Cell Proliferation * Cell Survival * Cytochalasin B * Cytokinesis * DNA Repair * E1A-Associated p300 Protein * Gene Expression Regulation * HCT116 Cells * Host-Pathogen Interactions * Humans * Keratinocytes * Oncogene Proteins, Viral * Osteoblasts * Papillomaviridae * Phenotype * Phosphorylation * Primary Cell Culture * Protein-Serine-Threonine Kinases * Signal Transduction * Transcription Factors * Tumor Suppressor Protein p53 |keywords=* Hippo signaling pathway * apoptosis * cancer * cytokinesis * human papillomavirus * senescence * skin cancer |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307087 }} ==HPSE== {{medline-entry |title=Distribution of heparan sulfate correlated with the expression of heparanase-1 and matrix metalloproteinase-9 in an ovariectomized rats skin. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32159248 |keywords=* aging * estrogen * extracellular matrix * heparan sulfate * heparanase-1 * matrix metalloproteinase-9 |full-text-url=https://sci-hub.do/10.1002/cbin.11339 }} ==HR== {{medline-entry |title=Patients with hip fracture and total hip arthroplasty surgery differ in anthropometric, but not cardiovascular screening abnormalities. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33267795 |keywords=* Aging * Cardiovascular reactivity * Heart rate variability * Hip fracture * Total hip arthroplasty |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7713041 }} {{medline-entry |title=Clinical Role of Lung Ultrasound for the Diagnosis and Prognosis of Coronavirus Disease Pneumonia in Elderly Patients: A Pivotal Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33271558 |keywords=* Aging * Coronavirus disease * Elderly * Lung ultrasound * Severe acute respiratory syndrome-coronavirus-2 |full-text-url=https://sci-hub.do/10.1159/000512209 }} {{medline-entry |title=The Relationship of Accelerometer-Assessed Standing Time With and Without Ambulation and Mortality: The WHI OPACH Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33225345 |keywords=* Accelerometer * Longevity * Physical activity |full-text-url=https://sci-hub.do/10.1093/gerona/glaa227 }} {{medline-entry |title=Age-related myofiber atrophy in old mice is reversed by ten weeks voluntary high-resistance wheel running. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33181317 |keywords=* Aging * Exercise * Mouse model * Muscle morphology * Skeletal muscle * Training |full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111150 }} {{medline-entry |title=Predicted Skeletal Muscle Mass and 4-Year Cardiovascular Disease Incidence in Middle-Aged and Elderly Participants of IKARIA Prospective Epidemiological Study: The Mediating Effect of Sex and Cardiometabolic Factors. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33121164 |keywords=* aging * body composition * gender * heart disease * lean mass * obesity * primary prevention * women |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693172 }} {{medline-entry |title=Obesity is associated with early hip fracture risk in postmenopausal women: a 25-year follow-up. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33095419 |keywords=* Aging * Body mass index * Bone mineral density * Follow-up study * General population * Hip fracture * Menopause * Obesity |full-text-url=https://sci-hub.do/10.1007/s00198-020-05665-w }} {{medline-entry |title=ATM inhibition synergizes with fenofibrate in high grade serous ovarian cancer cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33024871 |keywords=* Biochemistry * Bioinformatics * Cancer research * Cell biology * Cellular metabolism * Cellular senescence * Drug combinations * Homologous recombination * Metabolite * Molecular biology * PPARa |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527645 }} {{medline-entry |title=Effectiveness of adjuvant FOLFOX vs 5FU/LV in adults over age 65 with stage II and III colon cancer using a novel hybrid approach. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33015888 |keywords=* aging * cancer * chemotherapy * comparative effectiveness research * pharmacoepidemiology |full-text-url=https://sci-hub.do/10.1002/pds.5148 }} {{medline-entry |title=Age, Frailty, and Comorbidity as Prognostic Factors for Short-Term Outcomes in Patients With Coronavirus Disease 2019 in Geriatric Care. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32978065 |mesh-terms=* Age Factors * Aged * Aged, 80 and over * Betacoronavirus * COVID-19 * Comorbidity * Coronavirus Infections * Female * Frail Elderly * Geriatrics * Humans * Male * Models, Statistical * Outcome Assessment, Health Care * Pandemics * Pneumonia, Viral * Prognosis * SARS-CoV-2 * Survival Analysis * Sweden |keywords=* COVID-19 * aging * comorbidity * frailty * geriatrics * survival |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427570 }} {{medline-entry |title=Clinical and demographic parameters predict the progression from mild cognitive impairment to dementia in elderly patients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32918697 |keywords=* Aging * Cox regression * Dementia * Follow-up * Mild cognitive impairment |full-text-url=https://sci-hub.do/10.1007/s40520-020-01697-8 }} {{medline-entry |title=Plasma Dehydroepiandrosterone Sulfate and Cardiovascular Disease Risk in Older Men and Women. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32785663 |keywords=* DHEA-S * aging * heart failure * mortality |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526732 }} {{medline-entry |title=High intensity interval training combined with L-citrulline supplementation: Effects on physical performance in healthy older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32721549 |keywords=* Aging * Body composition * Exercise * Mobility * Nutrition |full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111036 }} {{medline-entry |title=Associations of blood pressure with risk of injurious falls in old age vary by functional status: A cohort study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32738383 |keywords=* Aging * Blood pressure * Falls * Injury * Swedish National study on Aging and Care in Kungsholmen (SNAC-K) |full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111038 }} {{medline-entry |title=Epigenetic age acceleration and clinical outcomes in gliomas. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32692766 |mesh-terms=* Adult * Aging * DNA Methylation * Epigenesis, Genetic * Female * Glioma * Humans * Male * Middle Aged * Prognosis * Survival Analysis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373289 }} {{medline-entry |title=Do Stairs Inhibit Seniors Who Live on Upper Floors From Going Out? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32666833 |keywords=* active aging * activity monitor * homebound * mobility * walk-up buildings |full-text-url=https://sci-hub.do/10.1177/1937586720936588 }} {{medline-entry |title=Age-specific acute changes in carotid-femoral pulse wave velocity with head-up tilt. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32634245 |keywords=* arterial function * arterial stiffness * blood pressure * early vascular aging * pressure dependence |full-text-url=https://sci-hub.do/10.1093/ajh/hpaa101 }} {{medline-entry |title=Pre-frailty status increases the risk of rehospitalization in patients after elective cardiac surgery without complication. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32531126 |mesh-terms=* Aged * Cardiac Surgical Procedures * Elective Surgical Procedures * Female * Frailty * Humans * Male * Patient Readmission * Postoperative Complications * Retrospective Studies * Risk |keywords=* adverse events * aging * cardiac surgery * frailty * rehospitalization |full-text-url=https://sci-hub.do/10.1111/jocs.14550 }} {{medline-entry |title=Comparative Performance of Creatinine-Based GFR Estimation Equations in Exceptional Longevity: The Rugao Longevity and Ageing Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32546991 |mesh-terms=* Aged, 80 and over * Creatinine * Female * Glomerular Filtration Rate * Humans * Kidney Function Tests * Longevity * Male * Mortality * Predictive Value of Tests * Renal Insufficiency * Reproducibility of Results * Risk Factors |keywords=* equation * exceptional longevity * glomerular filtration rate * kidney function * mortality |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266309 }} {{medline-entry |title=Sex-and race-specific associations of protein intake with change in muscle mass and physical function in older adults: the Health, Aging, and Body Composition (Health ABC) Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32520344 |mesh-terms=* Aged * Aged, 80 and over * Aging * Biomass * Body Composition * Body Weight * Dietary Proteins * Female * Humans * Independent Living * Male * Muscle Development * Muscle Strength * Muscles * Prospective Studies * Sex Factors |keywords=* appendicular lean body mass * community-dwelling * gait speed * mobility limitation * old age * optimal intake * physical performance * spline functions |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326591 }} {{medline-entry |title=Deterioration of bone microstructure by aging and menopause in Japanese healthy women: analysis by [[HR]]-pQCT. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32519249 |mesh-terms=* Absorptiometry, Photon * Adult * Aged * Aging * Asian Continental Ancestry Group * Bone Density * Bone and Bones * Cancellous Bone * Cortical Bone * Female * Finite Element Analysis * Humans * Japan * Linear Models * Menopause * Middle Aged * Porosity * Tomography, X-Ray Computed |keywords=* Bone microstructure * Estimated bone strength * High resolution peripheral quantitative CT (HR-pQCT) * Japanese women * Non-metric trabecular parameter |full-text-url=https://sci-hub.do/10.1007/s00774-020-01115-z }} {{medline-entry |title=Association between Low Protein Intake and Mortality in Patients with Type 2 Diabetes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32492838 |keywords=* aging * diabetes * mortality * nutritional support * protein intake |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352318 }} {{medline-entry |title=CAUSES, mortality rates and risk factors of death in community-dwelling Europeans aged 50 years and over: Results from the Survey of Health, Ageing and Retirement in Europe 2013-2015. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32325305 |mesh-terms=* Activities of Daily Living * Aged * Aging * Cohort Studies * Europe * Humans * Independent Living * Male * Middle Aged * Mortality * Proportional Hazards Models * Prospective Studies * Retirement * Risk Factors * Surveys and Questionnaires |keywords=* Aging * Comorbidity * Depressive symptoms * Diseases * Mortality risk |full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104035 }} {{medline-entry |title=Estimation of Wave Condition Number From Pressure Waveform Alone and Its Changes With Advancing Age in Healthy Women and Men. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32328003 |keywords=* arterial wave reflection * cardiovascular biomarker * optimum cardiovascular function * vascular aging * wave condition number |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161432 }} {{medline-entry |title=Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1-related genes and impairs DNA double-strand break recognition. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32333827 |keywords=* BRCA1 * DNA repair * cellular aging * homologous recombination * mesenchymal stem cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327915 }} {{medline-entry |title=Effect of artificial dawn light on cardiovascular function, alertness, and balance in middle-aged and older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32307533 |keywords=* aging * alertness * balance * blood pressure * heart rate * heart rate variability * light * sleep inertia |full-text-url=https://sci-hub.do/10.1093/sleep/zsaa082 }} {{medline-entry |title=Heart Rate Performance Curve Is Dependent on Age, Sex, and Performance. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32300582 |keywords=* aging * heart rate deflection * intensity prescription * maximal heart rate * sex differences * ß1-receptor sensitivity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144539 }} {{medline-entry |title=Physical activity trajectories, mortality, hospitalization, and disability in the Toledo Study of Healthy Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32163233 |keywords=* Adverse outcomes * Healthy aging * Mortality * Older adults * Physical activity * Trajectories |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432572 }} {{medline-entry |title=U-Shaped Association of Plasma Testosterone, and no Association of Plasma Estradiol, with Incidence of Fractures in Men. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32155267 |keywords=* estradiol * fracture * male aging * osteoporosis * sex hormone-binding globulin * testosterone |full-text-url=https://sci-hub.do/10.1210/clinem/dgaa115 }} {{medline-entry |title=Pregnancy-Related Bone Mineral and Microarchitecture Changes in Women Aged 30 to 45 Years. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32119748 |keywords=* AGING * ANALYSIS/QUANTITATION OF BONE * BONE QCT/μCT * EPIDEMIOLOGY * GENERAL POPULATION STUDIES |full-text-url=https://sci-hub.do/10.1002/jbmr.3998 }} {{medline-entry |title=Analysis of the world record time for combined father and son marathon. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31917623 |keywords=* V̇o2max * aerobic exercise * aging * endurance * oxygen consumption * running |full-text-url=https://sci-hub.do/10.1152/japplphysiol.00819.2019 }} {{medline-entry |title=Age-related reductions in heart rate variability do not worsen during exposure to humid compared to dry heat: A secondary analysis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31934605 |keywords=* Aging * autonomic nervous system * heat stress * parasympathetic nervous system * relative humidity * sympathetic nervous system |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949029 }} {{medline-entry |title=Efficacy and Safety of Dapagliflozin in the Elderly: Analysis From the DECLARE-TIMI 58 Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31843945 |mesh-terms=* Adult * Age Factors * Aged * Aged, 80 and over * Aging * Benzhydryl Compounds * Cardiovascular System * Diabetes Mellitus, Type 2 * Diabetic Ketoacidosis * Female * Glucosides * Humans * Hypoglycemia * Hypoglycemic Agents * Incidence * Kidney * Male * Middle Aged * Sodium-Glucose Transporter 2 Inhibitors * Survival Analysis * Treatment Outcome * Urinary Tract Infections |full-text-url=https://sci-hub.do/10.2337/dc19-1476 }} {{medline-entry |title=Validity of Prediction Equations of Maximal Heart Rate in Physically Active Female Adolescents and the Role of Maturation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31766291 |mesh-terms=* Adolescent * Aging * Body Mass Index * Exercise * Exercise Test * Female * Heart Rate * Humans |keywords=* cardiac rate * exercise prescription * exercise testing * prediction equations * training zones * volleyball |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915545 }} {{medline-entry |title=Base excision repair but not DNA double-strand break repair is impaired in aged human adipose-derived stem cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31782607 |mesh-terms=* Adipose Tissue * Adult * Aging * DNA Breaks, Double-Stranded * DNA End-Joining Repair * DNA Repair * Humans * Middle Aged * Recombinational DNA Repair * Stem Cells * Up-Regulation * X-ray Repair Cross Complementing Protein 1 * Young Adult |keywords=* XRCC1 * adipose-derived stem cells * base excision repair * genome integrity * human aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996963 }} {{medline-entry |title=Urban-Rural Differences in Hip Fracture Mortality: A Nationwide NOREPOS Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31768493 |keywords=* AGING * EPIDEMIOLOGY * GENERAL POPULATION STUDIES * OSTEOPOROSIS * STATISTICAL METHODS |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874178 }} {{medline-entry |title=Malnutrition as a Strong Predictor of the Onset of Sarcopenia. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31783482 |mesh-terms=* Aged * Aging * Cohort Studies * Female * Humans * Independent Living * Male * Malnutrition * Proportional Hazards Models * Prospective Studies * Risk Factors * Sarcopenia |keywords=* EWGSOP2 * GLIM * SarcoPhAge * malnutrition * sarcopenia |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950107 }} {{medline-entry |title=Acclimation to a thermoneutral environment abolishes age-associated alterations in heart rate and heart rate variability in conscious, unrestrained mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31776883 |keywords=* Aging * Cardiac autonomic modulation * Heart rate * Heart rate variability * Thermoneutrality |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031176 }} {{medline-entry |title=Long-term dementia risk prediction by the LIBRA score: A 30-year follow-up of the CAIDE study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31736136 |mesh-terms=* Aged * Apolipoproteins E * Cognitive Dysfunction * Dementia * Female * Follow-Up Studies * Genetic Predisposition to Disease * Humans * Life Style * Male * Protective Factors * Risk Assessment * Risk Factors |keywords=* cognitive aging * cohort study * dementia * epidemiology * lifestyle * prevention * risk factors |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003764 }} {{medline-entry |title=Kidney function and its association to imminent, short- and long-term fracture risk-a longitudinal study in older women. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31754754 |keywords=* Aging * Bone mineral density * Chronic kidney disease * Estimated glomerular filtration rate * Fracture * Women |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946753 }} {{medline-entry |title=Oxidatively Damaged DNA/RNA and 8-Isoprostane Levels Are Associated With the Development of Type 2 Diabetes at Older Age: Results From a Large Cohort Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31653645 |mesh-terms=* Age of Onset * Aged * Aging * Biomarkers * Cohort Studies * DNA * DNA Damage * Diabetes Mellitus, Type 2 * Dinoprost * Female * Follow-Up Studies * Germany * Humans * Incidence * Lipid Peroxidation * Male * Middle Aged * Oxidation-Reduction * Oxidative Stress * RNA |full-text-url=https://sci-hub.do/10.2337/dc19-1379 }} {{medline-entry |title=Associations of vigorous physical activity with all-cause, cardiovascular and cancer mortality among 64 913 adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31548909 |keywords=* cardio-protection * exercise * longevity * non-communicable diseases * physical activity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733336 }} {{medline-entry |title=Reduced cerebrovascular and cardioventilatory responses to intermittent hypoxia in elderly. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31557538 |mesh-terms=* Adult * Aged * Aging * Blood Pressure * Brain * Cerebrovascular Circulation * Female * Heart Rate * Humans * Hypoxia * Male * Pulmonary Ventilation * Ultrasonography, Doppler, Transcranial * Young Adult |keywords=* Aging * Arterial oxygen saturation * Cerebral blood flow * Cerebral tissue oxygenation * Heart rate * Hypoxemia * Ventilation |full-text-url=https://sci-hub.do/10.1016/j.resp.2019.103306 }} {{medline-entry |title=Vestibulo-sympathetic reflex in patients with bilateral vestibular loss. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31513442 |mesh-terms=* Aging * Bilateral Vestibulopathy * Female * Humans * Male * Middle Aged * Reflex, Abnormal * Sympathetic Nervous System |keywords=* bilateral vestibular loss * compensation * multisensory integration * otolithic system * vestibulo-sympathetic reflex |full-text-url=https://sci-hub.do/10.1152/japplphysiol.00466.2019 }} {{medline-entry |title=Heart rate and blood pressure in male Ts65Dn mice: a model to investigate cardiovascular responses in Down syndrome. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31496136 |mesh-terms=* Animals * Autonomic Nervous System * Blood Pressure * Circadian Rhythm * Down Syndrome * Heart Rate * Male * Mice * Mice, Inbred C57BL * Vascular Stiffness |keywords=* Aging * arterial stiffness * autonomic nervous system * circadian * pulse wave velocity * spectral analysis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732568 }} {{medline-entry |title=Body weight at 10 years of age and change in body composition between 8 and 10 years of age were related to survival in a longitudinal study of 39 Labrador retriever dogs. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31500653 |mesh-terms=* Adipose Tissue * Animals * Body Composition * Body Weight * Dogs * Longevity * Longitudinal Studies * Survival Analysis |keywords=* Cohort * Cox * DEXA * Dogs * Fat mass * Healthspan * Lean mass * Lean to fat ratio * Longevity * Sarcopenia |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734441 }} {{medline-entry |title=Dietary diversity offsets the adverse mortality risk among older indigenous Taiwanese. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31464406 |mesh-terms=* Aged * Aged, 80 and over * Asian Continental Ancestry Group * Diet * Female * Health Surveys * Humans * Indigenous Peoples * Longevity * Male * Mortality * Nutrition Surveys * Nutritional Status * Risk Factors * Taiwan |full-text-url=https://sci-hub.do/10.6133/apjcn.201909_28(3).0019 }} {{medline-entry |title=Independent and joint effects of vascular and cardiometabolic risk factor pairs for risk of all-cause dementia: a prospective population-based study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31455442 |mesh-terms=* Aged * Aged, 80 and over * Aging * Apolipoprotein E4 * Cognitive Dysfunction * Dementia * Exercise * Female * Heart Failure * Heterozygote * Humans * Hypertension * Male * Pennsylvania * Proportional Hazards Models * Prospective Studies * Risk Factors * Stroke |keywords=* Alzheimer‘s disease (AD) * apolipoprotein E (APOE) * cerebral vascular disease (CVD) * dementia * epidemiology |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948010 }} {{medline-entry |title=Work Ability and Job Survival: Four-Year Follow-Up. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31466415 |mesh-terms=* Adult * Brazil * Employment * Female * Follow-Up Studies * Hospitals * Humans * Male * Proportional Hazards Models * Work Capacity Evaluation |keywords=* aging * healthcare worker * life course * longitudinal studies * prolonged work career * work ability |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747402 }} {{medline-entry |title=Predictivity of bioimpedance phase angle for incident disability in older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31436391 |keywords=* Aging * Body composition * Cellular health * Muscle mass * Nutrition |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015240 }} ==HRAS== {{medline-entry |title=How do combinations of unhealthy behaviors relate to attitudinal factors and subjective health among the adult population in the Netherlands? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32245376 |mesh-terms=* Adult * Alcohol Drinking * Attitude to Health * Cluster Analysis * Diagnostic Self Evaluation * Diet, Healthy * Exercise * Female * Health Risk Behaviors * Humans * Life Expectancy * Life Style * Logistic Models * Male * Middle Aged * Netherlands * Prevalence * Sedentary Behavior * Smoking * Surveys and Questionnaires * Young Adult |keywords=* Clustering risk attitude * Health behaviours * Subjective health * Time orientation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126128 }} {{medline-entry |title=Elucidating Proteoform Dynamics Underlying the Senescence Associated Secretory Phenotype. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31940439 |keywords=* proteoform * quantitative proteomics * secretome * senescence * top-down proteomics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032038 }} ==HS2ST1== {{medline-entry |title=Whole Genome Analysis of the Red-Crowned Crane Provides Insight into Avian Longevity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31940721 |mesh-terms=* Animals * Avian Proteins * Birds * Endangered Species * Immunity * Longevity * Polymorphism, Genetic * Species Specificity * Transcriptome * Whole Genome Sequencing |keywords=* genome * longevity * red-crowned crane |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6999708 }} ==HSF1== {{medline-entry |title=A Mitochondrial Stress-Specific Form of [[HSF1]] Protects against Age-Related Proteostasis Collapse. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32735771 |keywords=* HSF1 * PP2A * aging * mitochondria * molecular chaperones * protein aggregation * proteostasis * stress responses |full-text-url=https://sci-hub.do/10.1016/j.devcel.2020.06.038 }} {{medline-entry |title=Heat shock factor 1-mediated transcription activation of Omi/HtrA2 induces myocardial mitochondrial apoptosis in the aging heart. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31627188 |mesh-terms=* Aging * Animals * Apoptosis * Heat Shock Transcription Factors * High-Temperature Requirement A Serine Peptidase 2 * Male * Mice * Mice, Inbred C57BL * Mitochondria, Heart * Myocytes, Cardiac * NIH 3T3 Cells * Transcriptional Activation * Up-Regulation |keywords=* Omi/HtrA2 * age-related pathology * cardiovascular * mitochondria * transcriptional regulation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834417 }} {{medline-entry |title=Multifactorial Attenuation of the Murine Heat Shock Response With Age. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31612204 |keywords=* Aging * HSF1 * Stress |full-text-url=https://sci-hub.do/10.1093/gerona/glz204 }} ==HSPA1A== {{medline-entry |title=Vitamin D3 treatment regulates apoptosis, antioxidant defense system, and DNA integrity in the epididymal sperm of an aged rat model. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31566824 |mesh-terms=* Aging * Animals * Antioxidants * Apoptosis * Cholecalciferol * Epididymis * Male * Rats * Rats, Wistar * Spermatozoa |keywords=* aging * apoptosis * oxidative stress * sperm |full-text-url=https://sci-hub.do/10.1002/mrd.23280 }} ==HSPA1L== {{medline-entry |title=Melatonin suppresses senescence-derived mitochondrial dysfunction in mesenchymal stem cells via the [[HSPA1L]]-mitophagy pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31965731 |keywords=* HSPA1L * melatonin * mesenchymal stem cells * mitochondria * mitophagy * replicative senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059143 }} ==HTT== {{medline-entry |title=Biological Aging and the Cellular Pathogenesis of Huntington's Disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32417788 |keywords=* Biological aging * DNA damage * Huntington’s disease * cellular aging * microsatellite instability * neurodegeneration * oxidative stress * proteostasis * telomere |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369111 }} ==ICE1== {{medline-entry |title=ATBS1-INTERACTING FACTOR 2 negatively regulates dark- and brassinosteroid-induced leaf senescence through interactions with INDUCER OF CBF EXPRESSION 1. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31783407 |keywords=* ATBS1-INTERACTING FACTOR 2 (AIF2) * Arabidopsis * C-REPEAT BINDING FACTOR (CBF) * INDUCER OF CBF EXPRESSION 1 (ICE1) * PHYTOCHROME-INTERACTING FACTORS (PIFs) * basic helix–loop–helix (bHLH) * brassinosteroid (BR) * leaf senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031079 }} ==IDE== {{medline-entry |title=Dendrobium nobile Lindl. Alkaloids Ameliorate Cognitive Dysfunction in Senescence Accelerated SAMP8 Mice by Decreasing Amyloid-β Aggregation and Enhancing Autophagy Activity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32538851 |keywords=* Aging * Dendrobium nobile Lindl. alkaloid (DNLA) * amyloid-β * autophagy * metformin * senescence accelerated mouse prone 8 (SAMP8) |full-text-url=https://sci-hub.do/10.3233/JAD-200308 }} ==IDH2== {{medline-entry |title=Reactive oxygen species-mediated senescence is accelerated by inhibiting Cdk2 in Idh2-deficient conditions. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31503005 |mesh-terms=* Animals * Cellular Senescence * Cyclin-Dependent Kinase 2 * Cyclin-Dependent Kinase Inhibitor p21 * Embryo, Mammalian * Fibroblasts * Isocitrate Dehydrogenase * Mice * Mice, Knockout * NIH 3T3 Cells * Reactive Oxygen Species |keywords=* cell cycle * cyclin-dependent kinase 2 (Cdk2) * isocitrate dehydrogenase 2 (IDH2) * reactive oxygen species (ROS) * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756887 }} ==IDS== {{medline-entry |title=Effect of immediate dentine sealing on the aging and fracture strength of lithium disilicate inlays and overlays. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32957211 |keywords=* Aging * Ceramic * Fracture strength * Immediate dentin sealing * Inlay * Overlay |full-text-url=https://sci-hub.do/10.1016/j.jmbbm.2020.103906 }} ==IFI27== {{medline-entry |title=Ultraviolet B irradiation-induced keratinocyte senescence and impaired development of 3D epidermal reconstruct. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33151171 |keywords=* epidermis * keratinocytes * reactive oxygen species * senescence * skin aging * ultraviolet radiation |full-text-url=https://sci-hub.do/10.2478/acph-2021-0011 }} ==IGF1== {{medline-entry |title=Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33105070 |keywords=* IGF1 * antagonistic gene * female sexual maturation * lifespan variation * maximum lifespan * sex difference in lifespan |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681063 }} {{medline-entry |title=17α-estradiol modulates [[IGF1]] and hepatic gene expression in a sex-specific manner. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32857104 |keywords=* 17α-estradiol * aging * growth hormone * insulin * insulin-like growth factor-1 * liver |full-text-url=https://sci-hub.do/10.1093/gerona/glaa215 }} {{medline-entry |title=Pan-mammalian analysis of molecular constraints underlying extended lifespan. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32043462 |keywords=* RERconverge * computational biology * evolution * genetics * genomics * longevity * mammals * phylogenomics * systems biology |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012612 }} {{medline-entry |title=17α-Estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31698046 |keywords=* Follicles * Ovarian aging * Ovarian reserve * Reproductive lifespan |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911620 }} ==IGF1R== {{medline-entry |title=Comparison of mitochondrial transplantation by using a stamp-type multineedle injector and platelet-rich plasma therapy for hair aging in naturally aging mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32707439 |keywords=* Aging mice * Hair growth * Mitochondrial transplantation * Pep-1 * Platelet-rich plasma |full-text-url=https://sci-hub.do/10.1016/j.biopha.2020.110520 }} ==IGFBP1== {{medline-entry |title=Role of [[IGFBP1]] in the senescence of vascular endothelial cells and severity of aging‑related coronary atherosclerosis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31545483 |mesh-terms=* Adult * Aged * Aged, 80 and over * Aging * Atherosclerosis * Cells, Cultured * Cellular Senescence * Coronary Artery Disease * Coronary Vessels * Down-Regulation * Endothelial Cells * Female * Humans * Insulin-Like Growth Factor Binding Protein 1 * Jagged-1 Protein * Male * Middle Aged * Signal Transduction * Up-Regulation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777673 }} ==IGFBP2== {{medline-entry |title=Intracellular Insulin-like growth factor binding protein 2 ([[IGFBP2]]) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32302288 |keywords=* insulin-like growth factor binding protein 2 * keratinocytes * p21CIP1/WAF1 * psoriasis * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202509 }} ==IGFBP3== {{medline-entry |title=Cellular and Molecular Biomarkers Indicate Premature Aging in Pseudoxanthoma Elasticum Patients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32489700 |keywords=* CCL11 * GDF11 * IGF1 * IGFBP * aging * pseudoxanthoma elasticum |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220280 }} {{medline-entry |title=Paracrine senescence of human endometrial mesenchymal stem cells: a role for the insulin-like growth factor binding protein 3. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31951594 |keywords=* IGFBP3 * endocytosis * endometrial stem cells * paracrine senescence * secretome |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053595 }} ==IGFBP4== {{medline-entry |title=Quantitative iTRAQ-based proteomic analysis of differentially expressed proteins in aging in human and monkey. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31601169 |mesh-terms=* Adult * Aged * Aged, 80 and over * Aging * Animals * Cognition * Female * Gene Expression Regulation * Gene Regulatory Networks * Haplorhini * Humans * Insulin-Like Growth Factor Binding Protein 4 * Male * Mice * Proteomics |keywords=* Cognitive dysfunction * IGFBP4 * Plasma * Quantitative proteomics * iTRAQ |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788010 }} ==IGFBP7== {{medline-entry |title=Reprogramming of human fibroblasts into osteoblasts by insulin-like growth factor-binding protein 7. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31904196 |keywords=* IGFBP7 * IL-6 * human fibroblast * osteoblast * reprogramming * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031646 }} ==IHH== {{medline-entry |title=Indian Hedgehog regulates senescence in bone marrow-derived mesenchymal stem cell through modulation of ROS/mTOR/4EBP1, p70S6K1/2 pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32235006 |keywords=* Indian hedgehog * aging * differentiation * mammalian target of rapamycin * mesenchymal stem cell |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185126 }} ==IL10== {{medline-entry |title=The beneficial effect of physical exercise on inflammatory makers in older individuals. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32504508 |keywords=* IL-6 expression * Inflammatory markers * aerobic exercise * aging * plasma IL-6 levels * resistance training |full-text-url=https://sci-hub.do/10.2174/1871530320666200606225357 }} {{medline-entry |title=Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14 , and TAU3 transcript expression and contribute to cognitive decline. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31654269 |mesh-terms=* Aged * Alternative Splicing * Astrocytes * Cells, Cultured * Cellular Senescence * Cognitive Dysfunction * Cytokines * Gene Expression * Glial Fibrillary Acidic Protein * Humans * Matrix Metalloproteinases * Transcription, Genetic * Tumor Suppressor Protein p14ARF * tau Proteins |keywords=* Alternative splicing * Gene expression * Neurodegenerative disease * Senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885035 }} {{medline-entry |title=Dietary Spray-Dried Porcine Plasma Prevents Cognitive Decline in Senescent Mice and Reduces Neuroinflammation and Oxidative Stress. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31562503 |mesh-terms=* Animals * Cognition Disorders * Encephalitis * Male * Mice * Oxidative Stress * Plasma * Swine |keywords=* aging * cognitive decline * dietary supplementation * neuroinflammation * spray-dried animal plasma |full-text-url=https://sci-hub.do/10.1093/jn/nxz239 }} ==IL15== {{medline-entry |title=Moderate physical activity associated with a higher naïve/memory T-cell ratio in healthy old individuals: potential role of [[IL15]]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32221610 |keywords=* T cells * ageing * immune senescence * older people * physical activity |full-text-url=https://sci-hub.do/10.1093/ageing/afaa035 }} ==IL1A== {{medline-entry |title=IL1B triggers inflammatory cytokine production in bovine oviduct epithelial cells and induces neutrophil accumulation via CCL2. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33099841 |keywords=* CCL2 * cellular senescence * inflammaging * senescence-associated secretory phenotype |full-text-url=https://sci-hub.do/10.1111/aji.13365 }} ==IL2== {{medline-entry |title=Impact of Aging on the Phenotype of Invariant Natural Killer T Cells in Mouse Thymus. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33193368 |keywords=* IL2 * aging * invariant natural killer T cells * thymus * transcriptome |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662090 }} ==IL6== {{medline-entry |title=Basic immunology may lead to translational therapeutic rationale: SARS-CoV-2 and rheumatic diseases. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32645207 |mesh-terms=* Adaptive Immunity * Aged * Antirheumatic Agents * COVID-19 * Comorbidity * Coronavirus Infections * Disease Outbreaks * Female * Humans * Hydroxychloroquine * Immunity, Innate * Immunologic Factors * Immunosuppressive Agents * Italy * Male * Middle Aged * Pandemics * Pneumonia, Viral * Rheumatic Diseases * Risk Assessment * Severe Acute Respiratory Syndrome |keywords=* COVID-19 * SARS-CoV-2 * geriatrics * pathophysiology * pediatrics * rheumatology |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404583 }} {{medline-entry |title=ATM-deficient neural precursors develop senescence phenotype with disturbances in autophagy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32621937 |keywords=* ATM * Ataxia-telangiectasia * Autophagy * Mitophagy * Neural progenitors * Oxidative stress * Senescence * hiPSCs |full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111296 }} {{medline-entry |title=The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32585876 |keywords=* IL6 * SASP * VSMCs * inflammaging * senescence * vascular calcification |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352675 }} {{medline-entry |title=Impact of Influenza on Pneumococcal Vaccine Effectiveness during [i]Streptococcus pneumoniae[/i] Infection in Aged Murine Lung. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32545261 |keywords=* Streptococcus pneumoniae * aging * influenza * vaccine effectiveness * viral immune imprinting |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7349919 }} {{medline-entry |title=Patterns of multi-domain cognitive aging in participants of the Long Life Family Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32514870 |keywords=* Aging * Biomarker * Cognition * Neuropsychology |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525612 }} {{medline-entry |title=Cholest-4,6-Dien-3-One Promote Epithelial-To-Mesenchymal Transition (EMT) in Biliary Tree Stem/Progenitor Cell Cultures In Vitro. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31731674 |mesh-terms=* Biliary Tract * Cell Differentiation * Cell Proliferation * Cells, Cultured * Cellular Senescence * Cholestenones * Epithelial-Mesenchymal Transition * Histone Deacetylase 6 * Humans * Interleukin-6 * Signal Transduction * Stem Cells * Tissue Donors |keywords=* BMP pathway * SHH pathway * biliary tree stem/progenitor cells (BTSCs) * epithelial-to-mesenchymal transition (EMT) * primary sclerosing cholangitis (PSC) * senescence * telomerase |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912632 }} {{medline-entry |title=Single xenotransplant of rat brown adipose tissue prolonged the ovarian lifespan of aging mice by improving follicle survival. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31389140 |mesh-terms=* Adipose Tissue, Brown * Animals * Cellular Senescence * Female * Longevity * Male * Mice * Ovarian Follicle * Ovary * Rats * Rats, Sprague-Dawley * Transplantation, Heterologous |keywords=* aging * brown adipose tissue (BAT) * lifespan * mice * ovary * rat * xenotransplant |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826128 }} ==ILDR1== {{medline-entry |title=Genome-wide association meta-analysis identifies five novel loci for age-related hearing impairment. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31645637 |mesh-terms=* Aging * Animals * Auditory Pathways * Female * Gene Expression Regulation * Genetic Loci * Genetic Predisposition to Disease * Genome-Wide Association Study * Hearing Loss * Humans * Male * Mice * Middle Aged * Molecular Sequence Annotation * Phenotype * Reproducibility of Results |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6811684 }} ==IMPACT== {{medline-entry |title=Load-dependent modulation of alpha oscillations during working memory encoding and retention in young and older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33141460 |keywords=* EEG * alpha oscillations * cognitive aging * working memory |full-text-url=https://sci-hub.do/10.1111/psyp.13719 }} {{medline-entry |title=Using Video Telehealth to Deliver Patient-Centered Collaborative Care: The G-[[IMPACT]] Pilot. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32228299 |keywords=* Telehealth * aging * care coordination * home care * interdisciplinary * medicine * older adult * video |full-text-url=https://sci-hub.do/10.1080/07317115.2020.1738000 }} {{medline-entry |title=AGING, HEART RATE VARIABILITY AND METABOLIC [[IMPACT]] OF OBESITY. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31969754 |mesh-terms=* Aging * Autonomic Nervous System * Autonomic Nervous System Diseases * Female * Heart Rate * Humans * Male * Metabolic Diseases * Metabolism * Middle Aged * Obesity |keywords=* Aging * Autonomic nervous system * Heart rate * Obesity, metabolically benign * Parasympathetic nervous system * Sympathetic nervous system |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971797 }} ==INS== {{medline-entry |title=Melatonin protects [[INS]]-1 pancreatic β-cells from apoptosis and senescence induced by glucotoxicity and glucolipotoxicity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32673151 |keywords=* Melatonin * Senescence * glucolipotoxicity * glucotoxicity * pancreatic β-cell |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527021 }} {{medline-entry |title=Nicotine triggers islet β cell senescence to facilitate the progression of type 2 diabetes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32473187 |mesh-terms=* Animals * Blotting, Western * Calcium * Cellular Senescence * Diabetes Mellitus, Type 2 * Disease Progression * Dose-Response Relationship, Drug * Enzyme-Linked Immunosorbent Assay * Glucose * Insulin-Secreting Cells * Male * Mice * Mice, Inbred C57BL * Nicotine * Reactive Oxygen Species * Real-Time Polymerase Chain Reaction * beta-Galactosidase |keywords=* ROS * islet β cells * nicotine * senescence * type 2 diabetes |full-text-url=https://sci-hub.do/10.1016/j.tox.2020.152502 }} ==INSL3== {{medline-entry |title=Effect of Thyroxine Replacement on Leydig Cell and Sertoli Cell Function in Men with Hypothyroidism. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33083267 |keywords=* Androgen deficiency in aging male * arizona sexual experience scale * hypothyroidism * inhibin B * insulin-like factor 3 * semen analysis * sperm motility |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7539029 }} ==IP6K1== {{medline-entry |title=The Role of the IGF-1 Signaling Cascade in Muscle Protein Synthesis and Anabolic Resistance in Aging Skeletal Muscle. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31552262 |keywords=* Akt * IP6K1 * aging * anabolic resistance * mTOR * protein * resistance exercise * sarcopenia |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746962 }} ==IQGAP1== {{medline-entry |title=[[IQGAP1]]-dysfunction leads to induction of senescence in human vascular smooth muscle cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32592713 |keywords=* Cellular bridges (CBs) * IQGAP1 * Intercellular communication * Senescence * Tunneling nanotubes (TNTs) * Vascular smooth muscle cells (VSMCs) |full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111295 }} {{medline-entry |title=Hyaluronan-binding protein 1 (HABP1) overexpression triggers induction of senescence in fibroblasts cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32068317 |keywords=* F-HABP07 * HABP1 * IQGAP1 * senescence |full-text-url=https://sci-hub.do/10.1002/cbin.11326 }} ==IRF8== {{medline-entry |title=[[IRF8]] induces senescence of lung cancer cells to exert its tumor suppressive function. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31594449 |mesh-terms=* A549 Cells * Animals * Carcinogenesis * Carcinoma, Non-Small-Cell Lung * Cell Movement * Cell Proliferation * Cellular Senescence * Gene Expression Regulation, Neoplastic * Heterografts * Humans * Interferon Regulatory Factors * Mice * Prognosis * Signal Transduction * Tumor Suppressor Proteins |keywords=* IRF8 * NSCLC * cell cycle arrest * cell senescence * tumor suppresser gene |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927690 }} ==IRS1== {{medline-entry |title=MicroRNA-34a causes ceramide accumulation and effects insulin signaling pathway by targeting ceramide kinase (CERK) in aging skeletal muscle. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32056304 |keywords=* CERK * aging muscle * insulin signaling pathway * miR-34a |full-text-url=https://sci-hub.do/10.1002/jcb.29312 }} {{medline-entry |title=Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31721422 |keywords=* IGF * aging * autophagy * insulin * lifespan * metabolism * polyamine |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974722 }} {{medline-entry |title=Serine Phosphorylation of [[IRS1]] Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31426549 |mesh-terms=* Aging * Alzheimer Disease * Amyloid beta-Peptides * Amyloid beta-Protein Precursor * Animals * Brain * Diabetes Mellitus, Type 2 * Humans * Insulin * Insulin Receptor Substrate Proteins * Male * Memory * Memory Disorders * Mice, Inbred C57BL * Mice, Transgenic * Phosphorylation * Serine * Signal Transduction |keywords=* AMPK * Alzheimer’s disease * Aβ * IRS1 * aging * diabetes * energy depletion * hippocampus * memory decline * serine phosphorylation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6723493 }} ==IRS2== {{medline-entry |title=Effects of Heshouwuyin on gene expression of the insulin/IGF signalling pathway in rat testis and spermatogenic cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33264567 |keywords=* IGF1 * IGFBP3 * INSR * IRS1 * IRS2 * Male reproduction * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717869 }} ==ITGA3== {{medline-entry |title=A transcriptomic analysis of serial-cultured, tonsil-derived mesenchymal stem cells reveals decreased integrin α3 protein as a potential biomarker of senescent cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32807231 |keywords=* AKT * Culture-aged * ECM-receptor protein * Integrin α3 * Senescence * Serial passaging * Tonsil-derived mesenchymal stem cells * Transcriptome |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7430027 }} ==ITGA5== {{medline-entry |title=Kaempferol alleviates the reduction of developmental competence during aging of porcine oocytes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31486245 |mesh-terms=* Animals * Blastocyst * Cellular Senescence * Embryo Culture Techniques * Embryo, Mammalian * Embryonic Development * Female * Integrins * Kaempferols * Mitochondria * Nanog Homeobox Protein * Octamer Transcription Factor-3 * Oocytes * Oxidative Stress * RNA, Messenger * Reactive Oxygen Species * Swine |keywords=* embryonic development * kaempferol * oocyte aging * porcine |full-text-url=https://sci-hub.do/10.1111/asj.13280 }} ==ITGAM== {{medline-entry |title=Comparative Analysis of Gene Expression Patterns for Oral Epithelium-Related Functions with Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31732940 |mesh-terms=* Aging * Animals * Disease Models, Animal * Epithelial Cells * Gingiva * Macaca mulatta * Oligonucleotide Array Sequence Analysis * Transcriptome |full-text-url=https://sci-hub.do/10.1007/978-3-030-28524-1_11 }} ==IVD== {{medline-entry |title=MicroRNAs in Intervertebral Disc Degeneration, Apoptosis, Inflammation, and Mechanobiology. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32443722 |keywords=* ECM * MMP * annulus fibrosus * cartilaginous endplate * degenerative disc disease * miRNA * nucleus pulposus * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279351 }} {{medline-entry |title=A step-by-step protocol for isolation of murine nucleus pulposus cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31891122 |keywords=* aging * gene expression * intervertebral disc degeneration * nucleus pulposus |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920701 }} {{medline-entry |title=Caspase-3 knockout inhibits intervertebral disc degeneration related to injury but accelerates degeneration related to aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31852919 |mesh-terms=* Aging * Animals * Annulus Fibrosus * Apoptosis * Biomarkers * Carcinogenesis * Caspase 3 * Cell Count * Extracellular Matrix * Intervertebral Disc * Intervertebral Disc Degeneration * Mice, Inbred C57BL * Mice, Knockout * Nucleus Pulposus * Up-Regulation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920379 }} {{medline-entry |title=Finite element and deformation analyses predict pattern of bone failure in loaded zebrafish spines. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31690186 |mesh-terms=* Aging * Animals * Back Pain * Disease Models, Animal * Finite Element Analysis * Humans * Intervertebral Disc * Movement * Weight-Bearing * Zebrafish |keywords=* deformation * finite element * geometric morphometrics * mechanics * spine * zebrafish |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893493 }} {{medline-entry |title=Improvement in determining the risk of damage to the human lumbar functional spinal unit considering age, height, weight and sex using a combination of FEM and RSM. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31473842 |mesh-terms=* Adult * Age Factors * Aging * Analysis of Variance * Biomechanical Phenomena * Body Height * Body Mass Index * Body Weight * Cortical Bone * Female * Finite Element Analysis * Humans * Imaging, Three-Dimensional * Intervertebral Disc * Lumbar Vertebrae * Male * Models, Biological * Range of Motion, Articular * Risk Factors * Sex Characteristics |keywords=* Age * Biomechanics * Body mass index (BMI) * Finite element method (FEM) * Functional spinal unit (FSU) * Height * Response surface method (RSM) * Sex * Weight |full-text-url=https://sci-hub.do/10.1007/s10237-019-01215-4 }} {{medline-entry |title=In vivo contrast-enhanced microCT for the monitoring of mouse thoracic, lumbar, and coccygeal intervertebral discs. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31463468 |keywords=* Contrast‐enhanced microCT * aging * intervertebral disc * mouse model |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686789 }} ==JAK1== {{medline-entry |title=Irradiation-induced senescence of bone marrow mesenchymal stem cells aggravates osteogenic differentiation dysfunction via paracrine signaling. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32233952 |mesh-terms=* Bone Resorption * Cell Cycle Checkpoints * Cell Differentiation * Cell Proliferation * Cellular Senescence * DNA Damage * Gene Expression Regulation, Developmental * Histones * Humans * Janus Kinase 1 * Mesenchymal Stem Cells * Mitochondria * Osteogenesis * Paracrine Communication * Radiation * Reactive Oxygen Species * STAT3 Transcription Factor * Signal Transduction |keywords=* SASP * bone marrow mesenchymal stem cells * cellular senescence * irradiation * osteogenic differentiation |full-text-url=https://sci-hub.do/10.1152/ajpcell.00520.2019 }} {{medline-entry |title=The Upregulation of Toll-Like Receptor 3 via Autocrine IFN-β Signaling Drives the Senescence of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Through [[JAK1]]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31396213 |mesh-terms=* Autocrine Communication * Cellular Senescence * Fetal Blood * Humans * Interleukin-6 * Janus Kinase 1 * Mesenchymal Stem Cells * Toll-Like Receptor 3 * Up-Regulation |keywords=* Janus kinase 1 (JAK1) * Toll-like receptor 3 (TLR3) * interferon-β (IFN-β) * mesenchymal stromal cell (MSC) * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6665952 }} ==JAK2== {{medline-entry |title=Senescence in Monocytes Facilitates Dengue Virus Infection by Increasing Infectivity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32850477 |keywords=* DC-SIGN * IL-10 * dengue virus * monocytes * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399640 }} {{medline-entry |title=Quercetin Directly Targets [[JAK2]] and PKCδ and Prevents UV-Induced Photoaging in Human Skin. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31652815 |mesh-terms=* Antioxidants * Cell Line * Cells, Cultured * Cyclooxygenase 2 * Humans * Janus Kinase 2 * MAP Kinase Signaling System * Matrix Metalloproteinase 1 * NF-kappa B * Protein Kinase C-delta * Quercetin * STAT3 Transcription Factor * Skin * Skin Aging * Transcription Factor AP-1 * Ultraviolet Rays |keywords=* JAK2 * PKC-delta * quercetin * skin aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862686 }} {{medline-entry |title=[Red blood cell lifespan detected by endogenous carbon monoxide breath test in patients with polycythemia vera]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31594177 |mesh-terms=* Adult * Aged * Aged, 80 and over * Breath Tests * Carbon Monoxide * Case-Control Studies * Erythrocyte Count * Erythrocytes * Female * Humans * Janus Kinase 2 * Longevity * Male * Middle Aged * Polycythemia Vera |keywords=* Carbon monoxide breath test * Polycythemia vera * Red blood cell lifespan |full-text-url=https://sci-hub.do/10.3760/cma.j.issn.0578-1426.2019.10.010 }} {{medline-entry |title=Roles of [[JAK2]] in Aging, Inflammation, Hematopoiesis and Malignant Transformation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31398915 |mesh-terms=* Aging * Animals * Hematopoiesis * Humans * Inflammation * Janus Kinase 2 * Mice * Myeloproliferative Disorders * Neoplasms |keywords=* JAK2 * Janus-kinase * aging * clonal hematopoiesis (CHIP), myeloproliferative neoplasia (MPN) |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721738 }} ==JUN== {{medline-entry |title=Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31794717 |mesh-terms=* Actin Cytoskeleton * Actins * Aging * Animals * Binding Sites * Caenorhabditis elegans * Caenorhabditis elegans Proteins * Intercellular Junctions * Intestinal Mucosa * JNK Mitogen-Activated Protein Kinases * Phosphorylation * Protein Phosphatase 1 * Transcription Factors * Troponin |keywords=* HSF-1 * actin * aging * barrier * intestine * junctions * kinase * pathogenesis * phosphorylation * stress |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897307 }} ==JUNB== {{medline-entry |title=Promotion of cellular senescence by THG-1/TSC22D4 knockout through activation of [[JUNB]]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31806366 |mesh-terms=* Cell Line, Tumor * Cell Proliferation * Cellular Senescence * Cyclin-Dependent Kinase Inhibitor p21 * Gene Expression Regulation, Neoplastic * Gene Knockout Techniques * HEK293 Cells * Humans * Transcription Factors * Transcription, Genetic * Up-Regulation |keywords=* Cellular senescence * JUNB * P21(CDKN1A) * THG-1(TSC22D4) |full-text-url=https://sci-hub.do/10.1016/j.bbrc.2019.11.145 }} ==KAT6B== {{medline-entry |title=Aging-associated decrease in the histone acetyltransferase [[KAT6B]] is linked to altered hematopoietic stem cell differentiation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32014431 |mesh-terms=* Aging * Animals * Cell Differentiation * Epigenesis, Genetic * Erythroid Cells * Gene Expression Profiling * Gene Expression Regulation, Enzymologic * Gene Knockout Techniques * Histone Acetyltransferases * Male * Mice * Mice, Transgenic * Myeloid Progenitor Cells * Transcriptome |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179256 }} ==KCNK2== {{medline-entry |title=Brain age prediction using deep learning uncovers associated sequence variants. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31776335 |mesh-terms=* Adolescent * Adult * Aged * Aged, 80 and over * Aging * Brain * Databases, Factual * Deep Learning * Genome-Wide Association Study * Humans * Iceland * Magnetic Resonance Imaging * Middle Aged * Neural Networks, Computer * Neuropsychological Tests * Polymorphism, Single Nucleotide * United Kingdom * Young Adult |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881321 }} ==KCNQ4== {{medline-entry |title=Guanylyl Cyclase A/cGMP Signaling Slows Hidden, Age- and Acoustic Trauma-Induced Hearing Loss. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32327991 |keywords=* KCNQ4 * PARP-1 * aging * cGMP * guanylyl cyclase A * hidden hearing loss * inner ear * otoprotection |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160671 }} ==KCTD12== {{medline-entry |title=The association between poverty and gene expression within peripheral blood mononuclear cells in a diverse Baltimore City cohort. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32970748 |mesh-terms=* Adult * Demography * Female * Gene Expression Profiling * Humans * Longevity * Male * Metabolic Networks and Pathways * Middle Aged * Monocytes * Poverty * Transcriptome * Urban Population |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7514036 }} ==KDM2A== {{medline-entry |title=SIRT6 mono-ADP ribosylates [[KDM2A]] to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32584788 |keywords=* DNA repair * SIRT6 * genome stability * longevity * transcription |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343504 }} ==KDM2B== {{medline-entry |title=Identification of Structural Elements of the Lysine Specific Demethylase 2B CxxC Domain Associated with Replicative Senescence Bypass in Primary Mouse Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32270414 |keywords=* Lysine demethylase * Non-methylated CpG * Oncogene * Polycomb repressive complex * Replicative senescence * Zn-finger |full-text-url=https://sci-hub.do/10.1007/s10930-020-09895-z }} ==KDM3A== {{medline-entry |title=[[KDM3A]] and KDM4C Regulate Mesenchymal Stromal Cell Senescence and Bone Aging via Condensin-mediated Heterochromatin Reorganization. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31704649 |keywords=* Cell Biology * DNA damage * Molecular Mechanism of Gene Regulation * Stem Cells Research * bone aging * condensin * epigenetic regulation * histone demethylase * mesenchymal stromal cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888768 }} ==KEAP1== {{medline-entry |title=NRF2 pathway activation by [[KEAP1]] inhibition attenuates the manifestation of aging phenotypes in salivary glands. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32590331 |keywords=* Aging * KEAP1 * Mouse * NRF2 * Salivary glands |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322188 }} {{medline-entry |title=Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32424161 |mesh-terms=* Adaptation, Physiological * Animals * Antioxidants * Basal Metabolism * Biological Evolution * Birds * Cell Nucleus * Feathers * Fibroblasts * Genomics * Glutathione Transferase * HEK293 Cells * Humans * Kelch-Like ECH-Associated Protein 1 * Longevity * NF-E2-Related Factor 2 * Oxidative Stress * Phylogeny * Proteasome Endopeptidase Complex * Protein Binding * Protein Transport * Ubiquitination * Up-Regulation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234996 }} ==KIN== {{medline-entry |title=The noncanonical small heat shock protein HSP-17 from [i]Caenorhabditis elegans[/i] is a selective protein aggregase. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32001616 |mesh-terms=* Animals * Caenorhabditis elegans * Caenorhabditis elegans Proteins * Casein Kinase I * Heat-Shock Proteins, Small * Longevity * Malate Dehydrogenase * Peptides * Protein Aggregates * Protein Folding * RNA Interference * RNA, Small Interfering * Recombinant Proteins |keywords=* Caenorhabditis elegans (C. elegans) * chaperone * protein aggregates * protein aggregation * protein folding * proteostasis * selective protein aggregase * small heat shock protein (sHsp) |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062175 }} ==KIT== {{medline-entry |title=Prediction of ovarian aging using ovarian expression of BMP15, GDF9, and C-[[KIT]]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32223330 |keywords=* BMP15 * C-KIT * GDF9 * Ovarian aging * biomarkers |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221484 }} ==KLF2== {{medline-entry |title=[[KLF2]] induces the senescence of pancreatic cancer cells by cooperating with FOXO4 to upregulate p21. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31866399 |mesh-terms=* Animals * Carcinogenesis * Cell Cycle Proteins * Cell Line * Cells, Cultured * Cellular Senescence * Cyclin-Dependent Kinase Inhibitor p21 * Forkhead Transcription Factors * Kruppel-Like Transcription Factors * Male * Mice * Mice, Nude * Pancreatic Neoplasms * Protein Binding * Up-Regulation |keywords=* FOXO4 * KLF2 * Pancreatic cancer * Senescence |full-text-url=https://sci-hub.do/10.1016/j.yexcr.2019.111784 }} ==KLF4== {{medline-entry |title=Extracellular Vesicles from Healthy Cells Improves Cell Function and Stemness in Premature Senescent Stem Cells by miR-302b and HIF-1α Activation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32630449 |keywords=* aging * extracellular vesicles * oxygen * physiological oxygen concentration * physioxia * redox * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357081 }} {{medline-entry |title=Soluble klotho regulates the function of salivary glands by activating [[KLF4]] pathways. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31581134 |mesh-terms=* Animals * Cells, Cultured * Down-Regulation * Gene Expression Regulation * Glucuronidase * HEK293 Cells * Humans * Kruppel-Like Transcription Factors * Membrane Proteins * Mice * Mice, Knockout * Nuclear Proteins * RNA Interference * RNA, Small Interfering * Salivary Glands |keywords=* KLF4 * aging * salivary gland * soluble klotho |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814581 }} ==KLF6== {{medline-entry |title=Krüppel-Like Factor 6 Is Required for Oxidative and Oncogene-Induced Cellular Senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31824948 |keywords=* DNA damage * KLF6 * cell proliferation * cellular senescence * ras oncogene |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882731 }} ==KRAS== {{medline-entry |title=Chemical Pathology of Homocysteine VIII. Effects of Tocotrienol, Geranylgeraniol, and Squalene on Thioretinaco Ozonide, Mitochondrial Permeability, and Oxidative Phosphorylation in Arteriosclerosis, Cancer, Neurodegeneration and Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33067202 |keywords=* adenosine triphosphate * aging * antioxidant * apoptosis * atherogenesis * cancer * carcinogenesis * cholesterol * free radical * geraniol * geranylgeraniol * homocysteine * menoquinone * mitochondrial dysfunction * mitochondrial membrane potential * mitochondrial permeability transition pore * mitophagy * neuro-degeneration * oxidative phosphorylation * oxidative stress * squalene * statin * stellate cells * testosterone * thioretinaco ozonide * thioretinamide * tocopherol * tocotrienol * ubiquinone }} {{medline-entry |title=Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32234521 |mesh-terms=* Aging * Animals * CD8-Positive T-Lymphocytes * Carcinoma, Pancreatic Ductal * Cell Line, Tumor * Cell Proliferation * Cyclin-Dependent Kinase 4 * Cyclin-Dependent Kinase 6 * Gene Expression Regulation, Neoplastic * Genes, ras * Humans * Immunotherapy * MAP Kinase Signaling System * Mice * Pancreatic Neoplasms * Retinoblastoma Protein * Signal Transduction * Tumor Microenvironment * Vascular Remodeling |keywords=* T cells * chemotherapy resistance * endothelial cell activation * immunotherapy * pancreatic cancer * senescence * senescence-associated secretory phenotype * targeted therapy * tumor microenvironment * vascular biology |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278897 }} ==L1CAM== {{medline-entry |title=Glioma malignancy is linked to interdependent and inverse AMOG and L1 adhesion molecule expression. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31510944 |mesh-terms=* Adenosine Triphosphatases * Apoptosis * Biomarkers * Brain Neoplasms * Cation Transport Proteins * Cell Adhesion * Cell Adhesion Molecules, Neuronal * Cell Line, Tumor * Cellular Senescence * Gene Expression Profiling * Gene Expression Regulation, Neoplastic * Glioblastoma * Humans * Immunohistochemistry * Neural Cell Adhesion Molecule L1 * RNA, Small Interfering * Signal Transduction |keywords=* AMOG * Apoptosis * Glioma * Human * L1CAM * Senescence * Therapy |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739972 }} ==LAG3== {{medline-entry |title=T Cell Transcriptional Profiling and Immunophenotyping Uncover [[LAG3]] as a Potential Significant Target of Immune Modulation in Multiple Myeloma. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31445183 |keywords=* Autologous stem cell transplant * Exhaustion * LAG3 * Multiple myeloma * Senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952061 }} ==LAMP1== {{medline-entry |title=Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32579115 |keywords=* CLN3 * TREM2 * aging * autofluorescence * immunology * inflammation * lysosomal storage disorder * microglia * mouse * neuroscience * rhesus macaque |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7367682 }} ==LBP== {{medline-entry |title=Lipopolysaccharide binding protein is associated with CVD risk in older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32895891 |keywords=* Aging * Cardiovascular disease risk * Intestinal permeability * Lipopolysaccharide binding protein |full-text-url=https://sci-hub.do/10.1007/s40520-020-01684-z }} {{medline-entry |title=Aging-related liver degeneration is associated with increased bacterial endotoxin and lipopolysaccharide binding protein levels. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32090603 |mesh-terms=* Acute-Phase Proteins * Aging * Animals * Apoptosis * Biomarkers * Carrier Proteins * Endotoxins * Female * Gene Expression Regulation * Glucose * Inflammation * Insulin Receptor Substrate Proteins * Liver * Liver Cirrhosis * Malate Dehydrogenase * Male * Membrane Glycoproteins * Mice * Mice, Inbred C57BL * Mice, Knockout * RNA, Messenger * Receptor, Insulin * Toll-Like Receptor 4 |keywords=* Tlr-4 signaling * aging * bacterial endotoxin * lipopolysaccharide binding protein * liver degeneration |full-text-url=https://sci-hub.do/10.1152/ajpgi.00345.2018 }} {{medline-entry |title=Biomarkers of leaky gut are related to inflammation and reduced physical function in older adults with cardiometabolic disease and mobility limitations. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31654268 |mesh-terms=* Aged * Aging * Biomarkers * Exercise Therapy * Female * Follow-Up Studies * Humans * Inflammation * Male * Metabolic Syndrome * Middle Aged * Mobility Limitation * Motor Activity * Obesity * Retrospective Studies * Weight Loss |keywords=* Ageing * Lipopolysaccharide-binding protein * Microbial translocation * Physical function |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925090 }} {{medline-entry |title=Needle-shaped amyloid deposition in rat mammary gland: evidence of a novel amyloid fibril protein. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31615282 |mesh-terms=* Aging * Amyloidogenic Proteins * Amyloidosis * Animals * Antigens, Surface * Female * Mammary Glands, Animal * Milk Proteins * Plaque, Amyloid * Rats * Rats, Sprague-Dawley |keywords=* Amyloidosis * lipopolysaccharide binding protein * mammary gland * pathology * rat |full-text-url=https://sci-hub.do/10.1080/13506129.2019.1675623 }} {{medline-entry |title=Effects of Lycium barbarum Polysaccharides on Health and Aging of [i]C. elegans[/i] Depend on [i]daf-12/daf-16[/i]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31583041 |mesh-terms=* Aging * Animals * Caenorhabditis elegans * Caenorhabditis elegans Proteins * Drugs, Chinese Herbal * Receptors, Cytoplasmic and Nuclear |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754959 }} ==LBR== {{medline-entry |title=Lamin B receptor: role on chromatin structure, cellular senescence and possibly aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32726434 |keywords=* Aging * cancer * cellular senescence * chromatine structure * nuclear envelop |full-text-url=https://sci-hub.do/10.1042/BCJ20200165 }} {{medline-entry |title=The impact of age beyond ploidy: outcome data from 8175 euploid single embryo transfers. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32173784 |keywords=* Aneuploidy * Pregestational genetic testing * Reproductive aging * Single embryo transfer |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7125286 }} {{medline-entry |title=The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP). |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32126237 |keywords=* Gene expression * LBR * SAHF * SASP * Senescence |full-text-url=https://sci-hub.do/10.1016/j.yexcr.2020.111927 }} {{medline-entry |title=Lamin B receptor plays a key role in cellular senescence induced by inhibition of the proteasome. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31825172 |keywords=* LBR * autophagy * proteasome * protein accumulation * senescence * unbalanced growth |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996348 }} ==LEP== {{medline-entry |title=Age- and Sex-Specific Changes in Lower-Limb Muscle Power Throughout the Lifespan. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31943003 |keywords=* Aging * Body mass index * Dynapenia * Leg extension power * Sarcopenia * Skeletal muscle |full-text-url=https://sci-hub.do/10.1093/gerona/glaa013 }} {{medline-entry |title=The Copenhagen Sarcopenia Study: lean mass, strength, power, and physical function in a Danish cohort aged 20-93 years. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31419087 |mesh-terms=* Adult * Aged * Aged, 80 and over * Body Composition * Cohort Studies * Cross-Sectional Studies * Denmark * Female * Hand Strength * Humans * Leg * Longevity * Middle Aged * Prospective Studies * Sarcopenia * Young Adult |keywords=* Body composition * DXA * Handgrip strength * Lean mass * Leg power * Sarcopenia |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6903448 }} ==LGR6== {{medline-entry |title=Effect of defensins-containing eye cream on periocular rhytids and skin quality. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32614135 |keywords=* aging * defensins * periocular * rhytids * skin |full-text-url=https://sci-hub.do/10.1111/jocd.13424 }} ==LHCGR== {{medline-entry |title=Comparative Study of the Steroidogenic Effects of Human Chorionic Gonadotropin and Thieno[2,3-D]pyrimidine-Based Allosteric Agonist of Luteinizing Hormone Receptor in Young Adult, Aging and Diabetic Male Rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33050653 |keywords=* aging rats * diabetes mellitus * human chorionic gonadotropin * low-molecular-weight agonist * luteinizing hormone receptor * spermatogenesis * steroidogenesis * testes |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7590010 }} ==LMNA== {{medline-entry |title=Metformin alters peripheral blood mononuclear cells (PBMC) senescence biomarkers gene expression in type 2 diabetic patients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33187870 |keywords=* Inflammation and cellular senescence * Insulin resistance * LMNA/C transcript variants * Mononuclear cells * Type 2 diabetes mellitus |full-text-url=https://sci-hub.do/10.1016/j.jdiacomp.2020.107758 }} {{medline-entry |title=Protein structural and mechanistic basis of progeroid laminopathies. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32799420 |keywords=* 3D structure * aging disorders * contact sites * lamin * nuclear structure |full-text-url=https://sci-hub.do/10.1111/febs.15526 }} {{medline-entry |title=Progerin Expression Induces Inflammation, Oxidative Stress and Senescence in Human Coronary Endothelial Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32408587 |keywords=* Hutchinson–Gilford progeria syndrome * LMNA * aging * atherosclerosis * endothelial dysfunction * inflammation * lamin A * prenylation * progerin |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290406 }} {{medline-entry |title=The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32196928 |keywords=* JAK/STAT pathway * cellular senescence * progeria * ruxolitinib |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189991 }} {{medline-entry |title=Pharmacotherapy to gene editing: potential therapeutic approaches for Hutchinson-Gilford progeria syndrome. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32048129 |keywords=* Aging * Extracellular vesicles * Hutchinson–Gilford progeria syndrome * Progerin * Stem cells * Therapeutics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205988 }} {{medline-entry |title=Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31794853 |keywords=* Aging * Animal model breeding * Bone strength * Hutchinson-Gilford Progeria Syndrome (HGPS) * Kyphosis * Quality of life |full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110784 }} ==LMNB1== {{medline-entry |title=SIRT1 - a new mammalian substrate of nuclear autophagy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33292048 |keywords=* Aging * SIRT1 * nuclear autophagy * senescence * sirtuin |full-text-url=https://sci-hub.do/10.1080/15548627.2020.1860541 }} {{medline-entry |title=Cellular senescence as a response to multiwalled carbon nanotube (MWCNT) exposure in human mesothelial cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33279583 |keywords=* alpha tubulin * cellular senescence * mesothelial cells * microarray analysis * multiwalled carbon nanotubes * γH2A.X |full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111412 }} {{medline-entry |title=Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32523550 |keywords=* aging * cardiovascular * inflammation * senescence * smooth muscle cell |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261939 }} ==LOX== {{medline-entry |title=12-[[LOX]] catalyzes the oxidation of 2-arachidonoyl-lysolipids in platelets generating eicosanoid-lysolipids that are attenuated by iPLA γ knockout. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32161117 |keywords=* 2-arachidonoyl-lysophospholipids * aging * calcium * eicosanoid * iPLA2γ * lysophospholipid * myocardium * platelet * platelet-type 12-lipoxygenase (12-LOX) * polyunsaturated fatty acids (PUFAs) |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170522 }} ==LOXL1== {{medline-entry |title=A blackberry-dill extract combination synergistically increases skin elasticity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32583541 |keywords=* blackberry-dill * elasticity * skin aging * skin physiology/structure * skin repair |full-text-url=https://sci-hub.do/10.1111/ics.12644 }} ==LOXL2== {{medline-entry |title=Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31569601 |mesh-terms=* Adenoviridae * Aging * Amino Acid Oxidoreductases * Animals * Arthritis, Experimental * Cartilage, Articular * Disease Models, Animal * Disease Progression * Gene Expression * Gene Transfer Techniques * Genetic Vectors * Interleukin-1beta * Mice * Mice, Transgenic * NF-kappa B * Osteoarthritis, Knee * Transduction, Genetic |keywords=* Lysyl oxidase like-2 * adenovirus delivery * anabolic response * articular cartilage * knee joint * osteoarthritis * regeneration |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801581 }} ==LPA== {{medline-entry |title=Ginseng gintonin, aging societies, and geriatric brain diseases. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32817818 |keywords=* Brain aging * Gintonin * Neurodegenerative diseases * Panax ginseng * Rejuvenation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426447 }} {{medline-entry |title=Late-life related subtypes of depression - a data-driven approach on cognitive domains and physical frailty. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32442243 |keywords=* cognitive aging * depression * frailty |full-text-url=https://sci-hub.do/10.1093/gerona/glaa110 }} {{medline-entry |title=Does sedentary time increase in older adults in the days following participation in intense exercise? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32130714 |mesh-terms=* Accelerometry * Aged * Exercise * Exercise Test * Humans * Sedentary Behavior * Sleep |keywords=* Aging * Compensation * High intensity * Movement behaviours |full-text-url=https://sci-hub.do/10.1007/s40520-020-01502-6 }} {{medline-entry |title=Association of Long-term Exposure to Elevated Lipoprotein(a) Levels With Parental Life Span, Chronic Disease-Free Survival, and Mortality Risk: A Mendelian Randomization Analysis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32108890 |mesh-terms=* Aged * Case-Control Studies * Cross-Sectional Studies * Female * Humans * Lipoprotein(a) * Longevity * Male * Mendelian Randomization Analysis * Middle Aged * Parents * Phenotype * Prospective Studies * Risk Factors |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049087 }} {{medline-entry |title=Elevated Autotaxin and [[LPA]] Levels During Chronic Viral Hepatitis and Hepatocellular Carcinoma Associate with Systemic Immune Activation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31769428 |keywords=* Aging * Autotaxin * Hepatitis * Hepatocellular Carcinoma * Immune Activation * Immunity * Inflammation * Liver * Lysophosphatidic Acid |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966516 }} {{medline-entry |title=Lysophosphatidic acid receptor [[LPA]] prevents oxidative stress and cellular senescence in Hutchinson-Gilford progeria syndrome. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31714004 |keywords=* 1-Oleoyl-2-O-methyl-rac-glycerophosphothionate * Hutchinson-Gilford progeria syndrome * LPA3 * cell senescence * lysophosphatidic acid * reactive oxygen species |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974717 }} {{medline-entry |title=Associations of Sedentary and Physically-Active Behaviors With Cognitive-Function Decline in Community-Dwelling Older Adults: Compositional Data Analysis From the NEIGE Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31656243 |keywords=* accelerometry * aging * exercise * neurocognitive disorders * sedentary lifestyle |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557173 }} {{medline-entry |title=Validation and comparison of two automated methods for quantifying brain white matter hyperintensities of presumed vascular origin. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31612759 |keywords=* White matter hyperintensity * brain aging * cerebral small vessel disease * lesion segmentation * methodology * validation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607266 }} {{medline-entry |title=The Sedentary Time and Physical Activity Levels on Physical Fitness in the Elderly: A Comparative Cross Sectional Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31581429 |mesh-terms=* Accelerometry * Aged * Aged, 80 and over * Aging * Body Mass Index * Cross-Sectional Studies * Exercise * Female * Humans * Male * Physical Fitness * Sedentary Behavior |keywords=* accelerometry * ageing * health * physical fitness * sedentary behaviour |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801920 }} {{medline-entry |title=Light-Intensity Physical Activity in a Large Prospective Cohort of Older US Adults: A 21-Year Follow-Up of Mortality. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31600755 |mesh-terms=* Aged * Cardiovascular Diseases * Cohort Studies * Exercise * Female * Follow-Up Studies * Humans * Leisure Activities * Male * Middle Aged * Mortality * Neoplasms * Proportional Hazards Models * Prospective Studies * Respiratory Tract Diseases * Risk Factors * Surveys and Questionnaires * United States |keywords=* Aging * Cancer prevention study * Leisure time physical activity * Light-intensity physical activity |full-text-url=https://sci-hub.do/10.1159/000502860 }} ==LPL== {{medline-entry |title=Survival analyses in Holstein cows considering direct disease diagnoses and specific SNP marker effects. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32684467 |keywords=* SNP effect * Weibull hazards model * genetic parameter * health disorder * longevity |full-text-url=https://sci-hub.do/10.3168/jds.2020-18174 }} {{medline-entry |title=Influence of common health disorders on the length of productive life and stayability in German Holstein cows. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31677834 |mesh-terms=* Animals * Breeding * Cattle * Cattle Diseases * Dairying * Farmers * Female * Lactation * Longevity * Phenotype |keywords=* genetic parameter * health disorder * longevity * subjective culling reason |full-text-url=https://sci-hub.do/10.3168/jds.2019-16985 }} ==LPO== {{medline-entry |title=[Features of the changes in lipid peroxidation and activity of Na+/K+-ATPase in the brain of the aged rats in the conditions of two-vessel cerebral ischemia/reperfusion.] |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32160433 |mesh-terms=* Aging * Animals * Brain Ischemia * Disease Models, Animal * Lipid Peroxidation * Rats * Reperfusion Injury * Sodium-Potassium-Exchanging ATPase |keywords=* Na+/K+-ATPase * aging * brain * lipid peroxidation * oxidative stress * stroke }} ==LRP1== {{medline-entry |title=Drug Targeting of Plasminogen Activator Inhibitor-1 Inhibits Metabolic Dysfunction and Atherosclerosis in a Murine Model of Metabolic Syndrome. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32268785 |mesh-terms=* Animals * Atherosclerosis * Cellular Senescence * Diet, Western * Disease Models, Animal * Indoleacetic Acids * Macrophages * Metabolic Syndrome * Mice * Mice, Knockout * Obesity * Plaque, Atherosclerotic * Plasminogen Activator Inhibitor 1 * Receptors, LDL |keywords=* atherosclerosis * cellular senescence * fibrinolysis * metabolic syndrome * muscle, smooth * obesity * plasminogen activator inhibitor-1 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255962 }} ==LRP4== {{medline-entry |title=Multiple MuSK signaling pathways and the aging neuromuscular junction. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32353380 |keywords=* Aging * BMP signaling * MuSK * Neuromuscular junction * Synaptic maintenance |full-text-url=https://sci-hub.do/10.1016/j.neulet.2020.135014 }} ==LRP6== {{medline-entry |title=Low-density lipoprotein receptor-related protein 6-mediated signaling pathways and associated cardiovascular diseases: diagnostic and therapeutic opportunities. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32076828 |mesh-terms=* Aging * Animals * Cardiovascular Diseases * Humans * Low Density Lipoprotein Receptor-Related Protein-6 * Muscle, Smooth, Vascular * Myocytes, Smooth Muscle * Obesity * Signal Transduction * Structure-Activity Relationship * Vascular Calcification * Wnt Signaling Pathway |full-text-url=https://sci-hub.do/10.1007/s00439-020-02124-8 }} ==LRRK2== {{medline-entry |title=Accelerated telomere shortening independent of [[LRRK2]] variants in Chinese patients with Parkinson's disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33122450 |keywords=* LRRK2 variants * Parkinson’s disease * aging * telomere length |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655166 }} {{medline-entry |title=The effect of [[LRRK2]] loss-of-function variants in humans. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32461697 |mesh-terms=* Adult * Aged * Aged, 80 and over * Biological Specimen Banks * Cell Line * Embryonic Stem Cells * Female * Gain of Function Mutation * Heterozygote * Humans * Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 * Longevity * Loss of Function Mutation * Lymphocytes * Male * Middle Aged * Myocytes, Cardiac * Parkinson Disease * Phenotype |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303015 }} {{medline-entry |title=Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32075681 |keywords=* And aging * Dendritic hypotrophy * Excitability * G2019S * GABAA * LRRK2 * Nuclear DNA damage * Nuclear hypertrophy * Nuclear invagination * Parkinson’s disease * R1441C * Striatal spiny projection neuron |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031993 }} {{medline-entry |title=Autophagy and [[LRRK2]] in the Aging Brain. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31920513 |keywords=* LAMP2A * LC3 * LRRK2 * Parkinson’s disease * aging * autophagy * lysosomes * α-synuclein |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928047 }} ==LSS== {{medline-entry |title=Surgical results in older patients with lumbar spinal stenosis according to gait speed in relation to the diagnosis for sarcopenia. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32329390 |keywords=* aging * elderly person * gait speed * lumbar spinal stenosis * lumbar spine * muscle strength * sarcopenia * skeletal muscle mass * surgical result |full-text-url=https://sci-hub.do/10.1177/2309499020918422 }} {{medline-entry |title=Streamlining an existing hip fracture patient pathway in an acute tertiary adult Irish hospital to improve patient experience and outcomes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31867664 |mesh-terms=* Aged * Aged, 80 and over * Delivery of Health Care, Integrated * Geriatrics * Hip Fractures * Hospitals, Teaching * Humans * Ireland * Length of Stay * Nerve Block * Orthopedics * Pain Management * Total Quality Management * Treatment Outcome |keywords=* Lean Six Sigma * healthcare outcomes * hip fracture care * integrated care pathways * interdisciplinary working * process improvement |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926383 }} ==LTA== {{medline-entry |title=Lipoteichoic acid from the cell wall of a heat killed Lactobacillus paracasei D3-5 ameliorates aging-related leaky gut, inflammation and improves physical and cognitive functions: from C. elegans to mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31814084 |keywords=* Aging * Cell wall * Cognition * Goblet cell * Inflammation * Leaky gut * Lipoteichoic acid * Metabolism * Mucin * Physical function * Probiotics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031475 }} {{medline-entry |title=The change of pain classes over time: a latent transition analysis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31680381 |mesh-terms=* Aged * Aging * Humans * Life Style * Longitudinal Studies * Middle Aged * Pain * Quality of Life |full-text-url=https://sci-hub.do/10.1002/ejp.1502 }} ==LY6D== {{medline-entry |title=[[LY6D]]-induced macropinocytosis as a survival mechanism of senescent cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33168631 |keywords=* LY6D * Ras protein * cellular senescence * endocytosis * lipid raft * macropinocytosis * vacuole |full-text-url=https://sci-hub.do/10.1074/jbc.RA120.013500 }} ==MAG== {{medline-entry |title=Exploration of life satisfaction of Korean people with sensory impairments across the lifespan. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32327387 |keywords=* Across the lifespan * Leisure domain * Life satisfaction * Sensory impairment * Social domain |full-text-url=https://sci-hub.do/10.1016/j.dhjo.2020.100931 }} ==MALT1== {{medline-entry |title=MALT-1 mediates IL-17 neural signaling to regulate C. elegans behavior, immunity and longevity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32350248 |mesh-terms=* Animals * Behavior, Animal * Caenorhabditis elegans * Caenorhabditis elegans Proteins * Gene Expression Regulation * Green Fluorescent Proteins * Immunity * Interleukin-17 * Interneurons * Longevity * Models, Biological * Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein * Neurons * Oxygen * Signal Transduction * Subcellular Fractions * Transgenes |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190641 }} {{medline-entry |title=[[MALT1]]-Deficient Mice Develop Atopic-Like Dermatitis Upon Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31632405 |mesh-terms=* Age Factors * Animals * CTLA-4 Antigen * Cytokines * Dermatitis, Atopic * Disease Models, Animal * Disease Susceptibility * Gene Expression * Genetic Predisposition to Disease * Immunoglobulin E * Lymphocyte Activation * Mice * Mice, Knockout * Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein * Skin * T-Lymphocyte Subsets |keywords=* MALT1 * Th2 * Tregs * aging * atopic dermatitis * lymphocytes * skin inflammation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779721 }} ==MAP2== {{medline-entry |title=Protective effects of ischemic preconditioning against neuronal apoptosis and dendritic injury in the hippocampus are age-dependent. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32314365 |keywords=* aging * diffusion tensor imaging * immunohistochemistry * ischemic preconditioning |full-text-url=https://sci-hub.do/10.1111/jnc.15029 }} ==MAP4K3== {{medline-entry |title=[[MAP4K3]]/GLK in autoimmune disease, cancer and aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31640697 |mesh-terms=* Aging * Autoimmune Diseases * Humans * Neoplasms * Protein-Serine-Threonine Kinases |keywords=* Aging * Autoimmune disease * Autophagy * Cancer metastasis * HPK1 * IL-17A * IQGAP1 * MAP4K3 (GLK) * PKCθ * Verteporfin |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6806545 }} ==MAPK1== {{medline-entry |title=Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32850814 |keywords=* MAPK1 * VB1 * purified vitexin compound 1 * senescence * skin photoaging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413062 }} ==MAPKAPK2== {{medline-entry |title=Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31801093 |mesh-terms=* AMP-Activated Protein Kinases * Animals * Calcium * Cell Line * Endocytosis * HEK293 Cells * Homeostasis * Humans * Intracellular Signaling Peptides and Proteins * Liver * Metformin * Mice * Phosphorylation * Protein Kinase C * Protein-Serine-Threonine Kinases * Proteomics * Signal Transduction |keywords=* AMPK3 * LKB1 * PKD1 * STIM1 * aging * calcium * diabetes * kinases * liver * metformin |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980792 }} ==MAPT== {{medline-entry |title=Association of relative brain age with tobacco smoking, alcohol consumption, and genetic variants. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32001736 |mesh-terms=* Aged * Aged, 80 and over * Aging * Alcohol Drinking * Biological Specimen Banks * Brain * Cognition * Female * Humans * Magnetic Resonance Imaging * Male * Middle Aged * Neuroimaging * Polymorphism, Single Nucleotide * Smoking * United Kingdom * tau Proteins |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6992742 }} {{medline-entry |title=A blood-based nutritional risk index explains cognitive enhancement and decline in the multidomain Alzheimer prevention trial. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31921969 |keywords=* Aging * Biomarkers of diet quality * Cognitive decline * DHA * EPA * Elderly * Homocysteine * Metabolomics * Nutrient biomarkers * Omega-3 fatty acids * Vitamin D |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944714 }} {{medline-entry |title=Longitudinal associations of physical activity levels with morphological and functional changes related with aging: The [[MAPT]] study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31669813 |mesh-terms=* Aged * Aged, 80 and over * Aging * Alzheimer Disease * Body Composition * Brain * Cognition * Exercise * Female * Humans * Longitudinal Studies * Male |keywords=* Aging * Biomarkers * Phenotype * Physical activity |full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110758 }} {{medline-entry |title=Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31673052 |mesh-terms=* Aging * Alzheimer Disease * Amyloid beta-Peptides * Amyloidosis * Animals * Disease Models, Animal * Mice * Mice, Transgenic * tau Proteins |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823454 }} {{medline-entry |title=Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31604111 |keywords=* Alzheimer’s disease * Ferroptosis * Iron * Reactive oxygen species * Senescence * Tau |full-text-url=https://sci-hub.do/10.1016/j.pneurobio.2019.101716 }} ==MATN3== {{medline-entry |title=Mice Lacking the Matrilin Family of Extracellular Matrix Proteins Develop Mild Skeletal Abnormalities and Are Susceptible to Age-Associated Osteoarthritis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31963938 |mesh-terms=* Aging * Animals * Cell Proliferation * Cells, Cultured * Chondrocytes * Disease Models, Animal * Female * Gene Knockout Techniques * Humans * Male * Matrilin Proteins * Mice * Mice, Knockout * Microscopy, Atomic Force * Muscle, Skeletal * Osteoarthritis |keywords=* articular cartilage * bone development * cartilage * matrilin * osteoarthritis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013758 }} ==MB== {{medline-entry |title=Probing menstrual bloodstain aging with fluorescence spectroscopy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33279406 |keywords=* Aging * Analytical methods * Blood * Fluorescence spectroscopy * Forensics |full-text-url=https://sci-hub.do/10.1016/j.saa.2020.119172 }} {{medline-entry |title=Effect of physical exercise and medication on enhancing cognitive function in older adults with vascular risk. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32989840 |mesh-terms=* Aged * Aged, 80 and over * Cognition * Cross-Sectional Studies * Exercise * Exercise Therapy * Female * Humans * Male * Middle Aged * Risk Factors * Vascular Diseases |keywords=* active aging * cognitive preservation * exercise habit * lifestyle advice * vascular care |full-text-url=https://sci-hub.do/10.1111/ggi.14048 }} {{medline-entry |title=A novel indenone derivative selectively induces senescence in MDA-[[MB]]-231 (breast adenocarcinoma) cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32956706 |mesh-terms=* Antineoplastic Agents * Breast Neoplasms * Catalysis * Cell Line, Tumor * Cell Survival * Cellular Senescence * Cyclin-Dependent Kinase Inhibitor p21 * Down-Regulation * Female * G1 Phase Cell Cycle Checkpoints * Humans * Palladium * Sulfonamides * Survivin * Tumor Suppressor Protein p53 * Up-Regulation |keywords=* Cell cycle arrest * Novel indenone derivative * Senescence * Triple-negative breast cancer |full-text-url=https://sci-hub.do/10.1016/j.cbi.2020.109250 }} {{medline-entry |title=Improved Autophagic Flux in Escapers from Doxorubicin-Induced Senescence/Polyploidy of Breast Cancer Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32846959 |keywords=* DNA damage * Rubicon * SQSTM1/p62 * TFEB * autophagic index * autophagy * cancer * polyploidy * senescence * senescence escape |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7504443 }} {{medline-entry |title=Lifespan regulation in α/β posterior neurons of the fly mushroom bodies by Rab27. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32627932 |keywords=* Drosophila * Rab27 * S6K * TOR * lifespan extension * mushroom body |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431830 }} {{medline-entry |title=Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32485849 |keywords=* apoptosis * cancer stem-like cells * doxorubicin * magnetic iron oxide nanoparticles * mitotic catastrophe * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352336 }} {{medline-entry |title="Mitotic Slippage" and Extranuclear DNA in Cancer Chemoresistance: A Focus on Telomeres. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32316332 |keywords=* ALT * SQSTM1/p62 * amoeboid conversion * budding of mitotic progeny * cellular senescence * extranuclear DNA * genotoxic treatment * inverted meiosis * mtTP53 cancer * polyploidization |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215480 }} {{medline-entry |title=Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31771226 |mesh-terms=* Antineoplastic Agents * Cell Proliferation * Cellular Senescence * Cyclin-Dependent Kinase Inhibitor p21 * Doxorubicin * Fluorouracil * Humans * Irinotecan * Methotrexate * Neoplasms * Oxaliplatin * Paclitaxel * Phenotype * Tumor Cells, Cultured |keywords=* DNA damage * SASP * cancer * chemotherapy * senescence * senescence markers |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952928 }} {{medline-entry |title=Downregulation of the inflammatory network in senescent fibroblasts and aging tissues of the long-lived and cancer-resistant subterranean wild rodent, Spalax. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31605433 |keywords=* Spalax * DNA damage * DNA repair * cellular senescence * interleukin-1 alpha (IL1α) * nuclear factor κB (NF-κB) * senescence-associated secretory phenotype (SASP) |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974727 }} {{medline-entry |title=Quantification of the health-status of the Dutch Labrador retriever population. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31494529 |mesh-terms=* Animals * Dog Diseases * Dogs * Female * Health Status * Insurance * Laboratories * Longevity * Male * Netherlands * Proportional Hazards Models * Risk Factors |keywords=* Canine health * Data analysis * Health parameters * Labrador retriever * Lifespan * Oncology |full-text-url=https://sci-hub.do/10.1016/j.prevetmed.2019.104764 }} {{medline-entry |title=Conjugated Physiological Resveratrol Metabolites Induce Senescence in Breast Cancer Cells: Role of p53/p21 and p16/Rb Pathways, and ABC Transporters. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31441212 |mesh-terms=* ATP-Binding Cassette Transporters * Breast Neoplasms * Cell Cycle Checkpoints * Cellular Senescence * Cyclin-Dependent Kinase Inhibitor p16 * Cyclin-Dependent Kinase Inhibitor p21 * Female * Glucuronides * Humans * MCF-7 Cells * Resveratrol * Retinoblastoma Protein * Signal Transduction * Stilbenes * Tumor Suppressor Protein p53 |keywords=* ABC transporters * breast cancer * deconjugation * resveratrol metabolites * senescence |full-text-url=https://sci-hub.do/10.1002/mnfr.201900629 }} ==MBP== {{medline-entry |title=Demyelination associated with chronic arsenic exposure in Wistar rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32171569 |mesh-terms=* Aging * Amyloid beta-Protein Precursor * Animals * Arsenic Poisoning * Arsenites * Axons * Corpus Callosum * Demyelinating Diseases * Diffusion Tensor Imaging * Drinking Water * Immunohistochemistry * Male * Mitochondria * Myelin Basic Protein * Neurofilament Proteins * Prefrontal Cortex * Rats * Rats, Wistar * Sodium Compounds * White Matter |keywords=* Amyloid * Anisotropy * Arsenic * Axonal damage * DTI * Demyelination * Development * MRI * Microstructure * Mitochondria |full-text-url=https://sci-hub.do/10.1016/j.taap.2020.114955 }} {{medline-entry |title=Natural killer cells as participants in pathogenesis of rat experimental autoimmune encephalomyelitis (EAE): lessons from research on rats with distinct age and strain. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32140045 |keywords=* EAE * NK cells * aging * dendritic cells * strain differences |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050050 }} ==MCC== {{medline-entry |title=Multiple chronic conditions and risk of cognitive impairment and dementia among older Americans: findings from the Aging, Demographics, and Memory Study (ADAMS). |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32633198 |keywords=* Aging * and memory study * cognitive impairment with no dementia * dementia * demographics * multimorbidity * multiple chronic conditions |full-text-url=https://sci-hub.do/10.1080/13825585.2020.1790492 }} {{medline-entry |title=Behaviour consistency is a sensitive tool for distinguishing the effects of aging on physical activity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32348871 |keywords=* Aging * Behaviour consistency * Heart rate * Physical activity * Treadmill running |full-text-url=https://sci-hub.do/10.1016/j.bbr.2020.112619 }} {{medline-entry |title=Burden on Caregivers of Adults with Multiple Chronic Conditions: Intersectionality of Age, Gender, Education level, Employment Status, and Impact on Social Life. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31475644 |keywords=* aging * analyse d’intersectionnalité * caregiver burden * fardeau de l’aidant * gender * interférence sociale * intersectionality analysis * maladies chroniques multiples * multiple chronic conditions * sexe * social interference * vieillissement |full-text-url=https://sci-hub.do/10.1017/S071498081900045X }} ==MCM9== {{medline-entry |title=MCM8- and [[MCM9]] Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31509747 |mesh-terms=* Aging * Animals * Apoptosis * Bone Marrow * Cell Differentiation * Cell Proliferation * DNA Damage * Gene Expression Regulation, Leukemic * Hematologic Neoplasms * Mice * Mice, Knockout * Minichromosome Maintenance Proteins * Retinoblastoma Protein * Signal Transduction * Splenomegaly * Tumor Suppressor Protein p53 |keywords=* DNA damage * DNA repair * MCM8 * MCM9 * cancer * hematopoiesis * homologous recombination * myelodysplastic syndrome |full-text-url=https://sci-hub.do/10.1016/j.celrep.2019.07.095 }} ==MCU== {{medline-entry |title=A rare case of Epstein-Barr virus-positive mucocutaneous ulcer that developed into an intestinal obstruction: a case report. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31931725 |mesh-terms=* Aged, 80 and over * Colon, Transverse * Epstein-Barr Virus Infections * Herpesvirus 4, Human * Humans * Intestinal Mucosa * Intestinal Obstruction * Male * Ulcer |keywords=* Aging * Epstein–Barr virus-positive mucocutaneous ulcer (EBV-MCU) * Immunosuppression * Intestinal obstruction * Surgical resection |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958744 }} {{medline-entry |title=Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31712319 |mesh-terms=* Adipocytes, Brown * Adipose Tissue, Brown * Aging * Animals * Calcium * Capsaicin * Gene Expression Regulation * Mice * Mice, Knockout * Mitochondria * Obesity * Sirtuin 3 |full-text-url=https://sci-hub.do/10.2337/db19-0526 }} ==MDH1== {{medline-entry |title=Oxidative Damage to the TCA Cycle Enzyme [[MDH1]] Dysregulates Bioenergetic Enzymatic Activity in the Aged Murine Brain. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32175745 |keywords=* DPM * MRM * TCA cycle * aging * brain |full-text-url=https://sci-hub.do/10.1021/acs.jproteome.9b00861 }} ==MDM2== {{medline-entry |title=SENEBLOC, a long non-coding RNA suppresses senescence via p53-dependent and independent mechanisms. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32030426 |mesh-terms=* Aging * Animals * Carcinogenesis * Cyclin-Dependent Kinase Inhibitor p21 * Gene Expression Regulation, Neoplastic * HCT116 Cells * Heterografts * Histone Deacetylases * Humans * Mice * Neoplasms * Protein Binding * RNA, Long Noncoding * Signal Transduction * Tumor Suppressor Protein p53 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102969 }} {{medline-entry |title=Disruption of Robo2-Baiap2 integrated signaling drives cystic disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31534052 |mesh-terms=* Animals * Cell Differentiation * Cell Proliferation * Cellular Senescence * Cilia * Disease Models, Animal * Epithelial Cells * Humans * Kidney * Kidney Diseases, Cystic * Mice * Mice, Knockout * Nerve Tissue Proteins * Protein Binding * Protein Domains * Receptors, Immunologic * Signal Transduction * Tumor Suppressor Protein p53 |keywords=* Cellular senescence * Development * Genetic diseases * Nephrology * Signal transduction |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795383 }} {{medline-entry |title=Senescence-induced immunophenotype, gene expression and electrophysiology changes in human amniocytes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31478614 |mesh-terms=* Amniocentesis * Amnion * Biomarkers * Cell Proliferation * Cells, Cultured * Cellular Senescence * Electrophysiological Phenomena * Female * Gene Expression Regulation * Humans * Immunophenotyping * Phenotype |keywords=* amniocyte * automated patch-clamp * flow cytometry * mesenchymal stem cell * qRT-PCR * replicative senescence * senescence-associated secretory phenotype |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815807 }} ==MED25== {{medline-entry |title=The [i]HAC1[/i] histone acetyltransferase promotes leaf senescence and regulates the expression of [i]ERF022[/i]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31468026 |keywords=* ERF022 * H3K9ac * HAC1 * Mediator complex * histone acetylation * leaf senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710649 }} ==MEFV== {{medline-entry |title=The grandfather's fever. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31401792 |mesh-terms=* Age of Onset * Aged, 80 and over * Familial Mediterranean Fever * Female * Humans * Male * Pedigree * Pyrin |keywords=* Autoinflammatory diseases * FMF * Genetics * Geriatrics * Periodic fever |full-text-url=https://sci-hub.do/10.1007/s10067-019-04741-9 }} ==MEOX2== {{medline-entry |title=Reduced expression of microRNA-130a promotes endothelial cell senescence and age-dependent impairment of neovascularization. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32457253 |keywords=* aging * angiogenesis * microRNA * neovascularization * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346016 }} ==MET== {{medline-entry |title=Self-rated health in relation to fruit and vegetable consumption and physical activity among older cancer survivors. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32979089 |keywords=* Cancer survivorship * Epidemiology * Fruit and vegetable * Gerontology * Physical activity |full-text-url=https://sci-hub.do/10.1007/s00520-020-05782-6 }} {{medline-entry |title=Leisure-time physical activity volume, intensity, and duration from mid- to late-life in U.S. subpopulations by race and sex. The Atherosclerosis Risk In Communities (ARIC) Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32170049 |keywords=* exercise * healthy aging * physical activity * retirement * successful aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093185 }} {{medline-entry |title=Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in [i]C. elegans[/i]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31815663 |mesh-terms=* Animals * Caenorhabditis elegans * Caenorhabditis elegans Proteins * Heterochromatin * Histone-Lysine N-Methyltransferase * Histones * Inheritance Patterns * Jumonji Domain-Containing Histone Demethylases * Longevity * Lysine * Methylation * Mutation |keywords=* C. elegans * COMPASS * aging * chromatin * chromosomes * epigenetics * gene expression * genetics * genomics * heterochromatin * transgenerational inheritance |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299346 }} {{medline-entry |title=Influence of Anthropometrics on Step-Rate Thresholds for Moderate and Vigorous Physical Activity in Older Adults: Scientific Modeling Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31518246 |keywords=* aging * cadence * physical activity intensity * public health * walking |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715008 }} ==MFI== {{medline-entry |title=The Influence of the Accelerated Aging Conditions on the Properties of Polyolefin Geogrids Used for Landfill Slope Reinforcement. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32825284 |keywords=* HDPE * accelerated aging tests * decrease mechanical properties * degradation * geosynthetics * landfill * polyolefin |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564637 }} {{medline-entry |title=Changes in Physical Meat Traits, Protein Solubility, and the Microstructure of Different Beef Muscles during Post-Mortem Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32575353 |keywords=* aging * beef muscle * microstructure * myofibril fragmentation * protein solubility |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353465 }} {{medline-entry |title=Effect of a low-voltage electrical stimulation on yak meat tenderness during postmortem aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32583539 |mesh-terms=* Animals * Cattle * Cold Temperature * Electric Stimulation * Food Handling * Food Quality * Food Storage * Hydrogen-Ion Concentration * Male * Meat * Muscle, Skeletal * Polysaccharides * Postmortem Changes * Time Factors |keywords=* Yak * electrical stimulation * postmortem aging * tenderness |full-text-url=https://sci-hub.do/10.1111/asj.13410 }} {{medline-entry |title=Comparative effects of dry-aging and wet-aging on physicochemical properties and digestibility of Hanwoo beef. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31480178 |keywords=* Beef Loin * Digestibility * Dry Aging * Shear Force * Wet Aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054618 }} ==MFN2== {{medline-entry |title=Thioredoxin protects mitochondrial structure, function and biogenesis in myocardial ischemia-reperfusion via redox-dependent activation of AKT-CREB- PGC1α pathway in aged mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33049718 |keywords=* aging * heart * ischemia-reperfusion * mitochondria * thioredoxin |full-text-url=https://sci-hub.do/10.18632/aging.104071 }} {{medline-entry |title=[[MFN2]] contributes to metabolic disorders and inflammation in the aging of rat chondrocytes and osteoarthritis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32416221 |keywords=* Aging * Inflammation * MFN2 * Metabolic disorders * Osteoarthritis |full-text-url=https://sci-hub.do/10.1016/j.joca.2019.11.011 }} ==MFSD2A== {{medline-entry |title=Decreased Blood Level of MFSD2a as a Potential Biomarker of Alzheimer's Disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31861865 |mesh-terms=* Aged * Alzheimer Disease * Biomarkers * Brain * Fatty Acids * Female * Humans * Male * Symporters |keywords=* Alzheimer’s disease * MFSD2a carrier * aging * neurologic disorders * omega-3 PUFA |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981746 }} ==MGMT== {{medline-entry |title=Cytotoxic and Senolytic Effects of Methadone in Combination with Temozolomide in Glioblastoma Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32977591 |keywords=* apoptosis * cancer therapy * drug resistance * glioblastoma * methadone * senescence * temozolomide |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7582495 }} ==MIA== {{medline-entry |title=Age, cohort, and period effects on metamemory beliefs. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31804113 |mesh-terms=* Aged * Aged, 80 and over * Aging * Cohort Studies * Cross-Sectional Studies * Female * Humans * Longitudinal Studies * Male * Metacognition * Middle Aged |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901096 }} {{medline-entry |title=Memory Age-based Stereotype Threat: Role of Locus of Control and Anxiety. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31752597 |mesh-terms=* Aged * Aging * Anxiety * Female * Humans * Internal-External Control * Male * Memory, Episodic * Metacognition * Middle Aged * Stereotyping |full-text-url=https://sci-hub.do/10.1080/0361073X.2019.1693009 }} ==MIB1== {{medline-entry |title=Immunohistochemical detection of senescence markers in human sarcomas. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31899047 |keywords=* SenTraGor * Senescence * p16 * p21 * sarcoma |full-text-url=https://sci-hub.do/10.1016/j.prp.2019.152800 }} ==MIP== {{medline-entry |title=Inspiratory muscle training improves cerebrovascular and postural control responses during orthostatic stress in older women. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32705393 |keywords=* Aging * Cardiac output * Center-of-pressure * Middle cerebral artery blood flow velocity * Respiratory muscles |full-text-url=https://sci-hub.do/10.1007/s00421-020-04441-2 }} {{medline-entry |title=A novel multi-marker discovery approach identifies new serum biomarkers for Parkinson's disease in older people: an EXosomes in PArkiNson Disease (EXPAND) ancillary study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32458283 |keywords=* Aging * Amino acids * Cytokines * Metabolomics * Neurodegeneration * Personalized medicine |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525911 }} {{medline-entry |title=Sexual dimorphism of physical activity on cognitive aging: Role of immune functioning. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32387511 |keywords=* Brain aging * Chemokines * Cognitive aging * Exercise * Gender * Inflammation * Lifestyle |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416443 }} {{medline-entry |title=Comparison of balance changes after inspiratory muscle or Otago exercise training. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31978126 |mesh-terms=* Aged * Aged, 80 and over * Aging * Breathing Exercises * Exercise * Exercise Therapy * Female * Humans * Male * Maximal Respiratory Pressures * Muscle Strength * Physical Endurance * Postural Balance * Respiratory Muscles * Respiratory Therapy |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980667 }} ==MITF== {{medline-entry |title=Thymocid , a Standardized Black Cumin ([i]Nigella sativa[/i]) Seed Extract, Modulates Collagen Cross-Linking, Collagenase and Elastase Activities, and Melanogenesis in Murine B16F10 Melanoma Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32707654 |keywords=* Nigella sativa * Thymocid® * black cumin * collagen * collagenase * cosmeceutical * elastase * glycation * melanogenesis * skin aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400895 }} {{medline-entry |title=HuRdling Senescence: HuR Breaks BRAF-Induced Senescence in Melanocytes and Supports Melanoma Growth. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32455577 |keywords=* HuR * MITF * Microphthalmia-associated transcription factor * malignant melanoma * oncogene induced senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281285 }} ==MLH1== {{medline-entry |title=The somatic mutation landscape of the human body. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31874648 |mesh-terms=* Age Factors * Aging * Humans * Mutation * Neoplasms * Selection, Genetic * Sex Factors |keywords=* Aging * Cancer * Genomic instability * Human * Somatic evolution * Somatic mutation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930685 }} ==MLKL== {{medline-entry |title=Remifentanil preconditioning protects against hypoxia-induced senescence and necroptosis in human cardiac myocytes [i]in vitro[/i]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32584786 |keywords=* cardiomyocytes * hypoxia * necroptosis * remifentanil * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425462 }} ==MLN== {{medline-entry |title=Age-Dependent Decrease in the Induction of Regulatory T Cells Is Associated With Decreased Expression of RALDH2 in Mesenteric Lymph Node Dendritic Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32849526 |keywords=* RALDH2 * aging * dendritic cells * epigenetic regulation * regulatory T cells * retinoic acid |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432217 }} ==MMD== {{medline-entry |title=Association between a Deficit Accumulation Frailty Index and Mobility Outcomes in Older Adults: Secondary Analysis of the Lifestyle Interventions and Independence for Elders (LIFE) Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33266358 |keywords=* LIFE Study * deficit accumulation * disability * frailty * healthy aging * mobility * older adults |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700674 }} {{medline-entry |title=Impact of Anticholinergic Medication Burden on Mobility and Falls in the Lifestyle Interventions for Elders (LIFE) Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32947839 |keywords=* anticholinergic burden * falls * mobility * physical activity * successful aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7564216 }} {{medline-entry |title=Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32105353 |keywords=* aging * mobility disability * multicenter trialphysical activity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187344 }} ==MME== {{medline-entry |title=Geriatric Opioid Harm Reduction: Interprofessional Student Learning Outcomes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32284953 |keywords=* aging * older adults * opioid harm reduction * overdose risk |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139179 }} {{medline-entry |title=Effectiveness of local anesthetic injection in geriatric patients following operative management of proximal and diaphyseal femur fracture. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31564373 |mesh-terms=* Aged * Aged, 80 and over * Analgesics, Opioid * Anesthetics, Local * Delirium * Female * Femoral Fractures * Fracture Fixation, Internal * Geriatrics * Humans * Injections, Intra-Articular * Intraoperative Care * Male * Pain Management * Pain, Postoperative * Retrospective Studies |keywords=* Geriatrics * Hip fracture * Local anesthetic * Narcotics |full-text-url=https://sci-hub.do/10.1016/j.injury.2019.09.013 }} ==MMP1== {{medline-entry |title=Reacquisition of a spindle cell shape does not lead to the restoration of a youthful state in senescent human skin fibroblasts. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32533368 |keywords=* Cell shape * Fibroblast * Lithography * SASP * Senescence |full-text-url=https://sci-hub.do/10.1007/s10522-020-09886-8 }} {{medline-entry |title=A novel multifunctional skin care formulation with a unique blend of antipollution, brightening and antiaging active complexes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31584241 |keywords=* anti-wrinkle * pigmentation * pollution * skin aging * skin barrier |full-text-url=https://sci-hub.do/10.1111/jocd.13176 }} ==MMP13== {{medline-entry |title=Aging aggravates intervertebral disc degeneration by regulating transcription factors toward chondrogenesis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31909538 |mesh-terms=* Aging * Animals * Antigens, Differentiation * Chondrocytes * Chondrogenesis * Core Binding Factor Alpha 1 Subunit * Fetal Proteins * Gene Expression Regulation * Intervertebral Disc Degeneration * Mice * Mice, Transgenic * Sp7 Transcription Factor * T-Box Domain Proteins |keywords=* Wnt/β-catenin/LRPs * biomechanics * genetic animal models * osterix |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018543 }} ==MOS== {{medline-entry |title=Effect of mannan oligosaccharides on the microbiota and productivity parameters of Litopenaeus vannamei shrimp under intensive cultivation in Ecuador. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32066764 |mesh-terms=* Actinobacteria * Aeromonas * Animal Feed * Animals * Aquaculture * Bacterial Adhesion * Ecuador * Flavobacteriaceae * Lactococcus * Longevity * Mannans * Microbiota * Oligosaccharides * Penaeidae * Proteobacteria * Seafood * Shewanella * Verrucomicrobia * Vibrio |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026423 }} {{medline-entry |title=Predictors of health-related quality of life among older adults living with HIV in Thailand: results from the baseline and follow-up surveys. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31870166 |keywords=* Chiang Mai * HIV and aging * Older adults living with HIV * Thailand * health-related quality of life * quality of life |full-text-url=https://sci-hub.do/10.1080/09540121.2019.1707472 }} {{medline-entry |title=Comparison of health-related quality of life between the Han and Yi ethnicity elderly in the Yi autonomous areas of Yunnan Province. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31766992 |mesh-terms=* Activities of Daily Living * Aged * Aged, 80 and over * Aging * China * Cross-Sectional Studies * Ethnic Groups * Female * Humans * Male * Middle Aged * Quality of Life |keywords=* ADL * Elderly * Health-related quality of life * IADL * Yi ethnic minority |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6878633 }} {{medline-entry |title=Mannan oligosaccharide increases the growth performance, immunity and resistance capability against Vibro Parahemolyticus in juvenile abalone Haliotis discus hannai Ino. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31561025 |mesh-terms=* Animal Feed * Animals * Antioxidants * Diet * Dietary Supplements * Dose-Response Relationship, Drug * Gastropoda * Immunity, Innate * Longevity * Mannans * Oligosaccharides * Vibrio parahaemolyticus |keywords=* Abalone * Antioxidation * Bacterial challenge * Disease resistance * Growth * Immunity * Mannan oligosaccharide |full-text-url=https://sci-hub.do/10.1016/j.fsi.2019.09.058 }} ==MPHOSPH6== {{medline-entry |title=Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32109421 |mesh-terms=* Genome-Wide Association Study * Humans * Leukocytes * Nucleotides * Telomere |keywords=* Mendelian randomisation * age-related disease * biological aging * telomere length |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058826 }} ==MPI== {{medline-entry |title=Age-related decline of lymphatic drainage from the eye: A noninvasive in vivo photoacoustic tomography study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32251650 |keywords=* Age-related * Aging * Aqueous humor * Drainage * Eye * Glaucoma * Imaging * In vivo * Lymph node * Lymphatic * Mice * Photoacoustic tomography * Uveoscleral |full-text-url=https://sci-hub.do/10.1016/j.exer.2020.108029 }} {{medline-entry |title=Interest of the multidimensional prognostic index ([[MPI]]) as an assessment tool in hospitalized patients in geriatrics. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31570330 |mesh-terms=* Aged, 80 and over * Female * Geriatric Assessment * Hospital Mortality * Hospitalization * Humans * Length of Stay * Male * Patient Readmission * Prognosis |keywords=* elderly * geriatrics * hospitalization * multidimensional prognostic index |full-text-url=https://sci-hub.do/10.1684/pnv.2019.0823 }} ==MRE11== {{medline-entry |title=Chromosomal alterations among age-related haematopoietic clones in Japan. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32581364 |mesh-terms=* Aged, 80 and over * Aging * Alleles * Cell Lineage * Chromosome Aberrations * Chromosomes, Human * Clone Cells * Cohort Studies * Female * Genetic Loci * Genome, Human * Hematopoiesis * Hematopoietic Stem Cells * Humans * Japan * Leukemia, Lymphocytic, Chronic, B-Cell * Leukemia, T-Cell * Male * Mosaicism * Mutation * United Kingdom |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489641 }} ==MSC== {{medline-entry |title=Rejuvenation of Senescent Endothelial Progenitor Cells by Extracellular Vesicles Derived From Mesenchymal Stromal Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33294742 |keywords=* BM, bone marrow * CVD, cardiovascular disease * EC, endothelial cell * EPC, endothelial progenitor cell * EV, extracellular vesicle * FBS, fetal bovine serum * MEM, minimum essential medium * MI, myocardial infarction * MSC, mesenchymal stromal cell * NTA, nanotracking analysis * PBS, phosphate-buffered saline * TEV, tailored extracellular vesicle * VEGF, vascular endothelial growth factor * acellular * angiogenesis * extracellular vesicles * lin− BMC, lineage negative bone marrow cell * miR, microRNA * qPCR, quantitative transcription polymerase chain reaction * regeneration * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691285 }} {{medline-entry |title=Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33264634 |keywords=* Aging * Cortical injury * Extracellular vesicles * Monkeys * Myelin * Non-human primates * Oligodendrocytes * Stroke * White matter |full-text-url=https://sci-hub.do/10.1016/j.expneurol.2020.113540 }} {{medline-entry |title=TPP1 Enhances the Therapeutic Effects of Transplanted Aged Mesenchymal Stem Cells in Infarcted Hearts via the MRE11/AKT Pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33195247 |keywords=* DNA repair * aging * myocardial infarction * stem cells therapy * telomere |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658181 }} {{medline-entry |title=Aging-Affected [[MSC]] Functions and Severity of Periodontal Tissue Destruction in a Ligature-Induced Mouse Periodontitis Model. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143068 |keywords=* aging * bone resorption * immunomodulation * mesenchymal stem cell * periodontitis * tissue destruction |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663404 }} {{medline-entry |title=Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33153492 |keywords=* Aging * Follicular development * Hormone biosynthesis * Primordial follicle activation * Stem cell therapy * miR-145 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643421 }} {{medline-entry |title=Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33102483 |keywords=* adult stem cells * aging * mesenchymal stromal cells (MSC) * regenerative medicine * stem cell niche |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546871 }} {{medline-entry |title=The biology of human hair greying. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32965076 |keywords=* ageing * endocrine * graying * melanin * senescence |full-text-url=https://sci-hub.do/10.1111/brv.12648 }} {{medline-entry |title=[i]Tsc1[/i] Regulates the Proliferation Capacity of Bone-Marrow Derived Mesenchymal Stem Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32927859 |keywords=* TSC1 * mammalian target of rapamycin (mTOR) * mesenchymal stem cell * senescence * stem cell proliferation * tuberous sclerosis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565438 }} {{medline-entry |title=The role of mitochondrial dysfunction in mesenchymal stem cell senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32803322 |keywords=* Mesenchymal stem cells * Mitochondrial dysfunction * Mitophagy * Reactive oxygen species * Senescence |full-text-url=https://sci-hub.do/10.1007/s00441-020-03272-z }} {{medline-entry |title=Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem/stromal cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32787856 |keywords=* EV * MSC * Metabolic syndrome * RNA-sequencing * Senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425605 }} {{medline-entry |title=Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32699947 |keywords=* Aging diseases * Conditioned medium * Diabetes * Exosomes * Extracellular vesicles * Lupus * Regenerative medicine * Secretome |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375036 }} {{medline-entry |title=Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of [[MSC]]s. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32660632 |keywords=* Aging * Heterochromatin * MSC senescence * mTORC1/p70S6K |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359252 }} {{medline-entry |title=Increased cellular senescence in the murine and human stenotic kidney: Effect of mesenchymal stem cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32657444 |keywords=* cellular senescence * exosomes * kidney * mesenchymal stem cells * renal artery obstruction |full-text-url=https://sci-hub.do/10.1002/jcp.29940 }} {{medline-entry |title=Intrinsic Type 1 Interferon (IFN1) Profile of Uncultured Human Bone Marrow CD45 CD271 Multipotential Stromal Cells (BM-[[MSC]]s): The Impact of Donor Age, Culture Expansion and IFNα and IFNβ Stimulation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32679782 |keywords=* aging * bone marrow * mesenchymal stromal cells * senescence * type 1 interferon |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399891 }} {{medline-entry |title=Facial rejuvenation using stem cell conditioned media combined with skin needling: A split-face comparative study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32623814 |keywords=* amniotic fluid stem cells products * dermaroller * facial aging * skin needling |full-text-url=https://sci-hub.do/10.1111/jocd.13594 }} {{medline-entry |title=Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32582691 |keywords=* autophagy * mesenchymal stem cells * mitochondrial * rejuvenation * senescence * telomere |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283395 }} {{medline-entry |title=The changing epigenetic landscape of Mesenchymal Stem/Stromal Cells during aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32445894 |keywords=* Aging * DNA methylation * Epigenetics * Histome modifications * MSC * Mesenchymal Stem/Stromal Cells * Skeleton * miRNA |full-text-url=https://sci-hub.do/10.1016/j.bone.2020.115440 }} {{medline-entry |title=Dual Role of Autophagy in Regulation of Mesenchymal Stem Cell Senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32391362 |keywords=* SASP * general autophagy * mesenchymal stem cell * selective autophagy * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193103 }} {{medline-entry |title=Molecular Aspects of Adipose-Derived Stromal Cell Senescence in a Long-Term Culture: A Potential Role of Inflammatory Pathways. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32314614 |keywords=* adipose-derived stromal/stem cell * aging * gene expression * long-term culture * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586277 }} {{medline-entry |title=Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32274385 |keywords=* adipose tissue * cellular dysfunction * cellular senescence * mesenchymal stem cells * obesity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113401 }} {{medline-entry |title=miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32196916 |keywords=* mesenchymal stem cells * miR-155-5p * myocardial infarction * rejuvenation * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189985 }} {{medline-entry |title=Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32154253 |keywords=* aging * clinical translation * extracellular vesicles * mesenchymal stem cells * regenerative medicine * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047768 }} {{medline-entry |title=Molecular Mechanisms Contributing to Mesenchymal Stromal Cell Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32098040 |keywords=* MSC senescence * in vitro aging * in vivo aging * mesenchymal stem/stromal cells (MSC) * rejuvenating strategies |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072652 }} {{medline-entry |title=Inhibition of DNA Methyltransferase by RG108 Promotes Pluripotency-Related Character of Porcine Bone Marrow Mesenchymal Stem Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32125888 |keywords=* RG108 * apoptosis * pluripotency * porcine bone marrow mesenchymal stem cells * senescence |full-text-url=https://sci-hub.do/10.1089/cell.2019.0060 }} {{medline-entry |title=Extracellular Vesicles of Stem Cells to Prevent BRONJ. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32119600 |keywords=* bisphosphonate-associated osteonecrosis of the jaw * cellular senescence * exosomes * mesenchymal stem cells * wound healing * zoledronic acid |full-text-url=https://sci-hub.do/10.1177/0022034520906793 }} {{medline-entry |title=Ginsenoside Rg1 as an Effective Regulator of Mesenchymal Stem Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32038244 |keywords=* apoptosis * differentiation * ginsenoside Rg1 * mesenchymal stem cells * preclinical study * proliferation * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989539 }} {{medline-entry |title=The Importance of Stem Cell Senescence in Regenerative Medicine. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32026416 |keywords=* Aging * Mesenchymal stem cell * Regenerative medicine |full-text-url=https://sci-hub.do/10.1007/5584_2020_489 }} {{medline-entry |title=Control of mesenchymal stem cell biology by histone modifications. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32025282 |keywords=* Cell biology * Cell differentiation * Cellular senescence * Epigenetics * Histone modifications * Mesenchymal stem cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996187 }} {{medline-entry |title=Impact of mesenchymal stem cell senescence on inflammaging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31964472 |mesh-terms=* Aging * Cellular Senescence * Cytokines * Hematopoiesis * Humans * Immunomodulation * Immunosenescence * Inflammation * Macrophages * Mesenchymal Stem Cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061209 }} {{medline-entry |title=Late Rescue Therapy with Cord-Derived Mesenchymal Stromal Cells for Established Lung Injury in Experimental Bronchopulmonary Dysplasia. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31918630 |keywords=* COPD * aging * lung * newborn * regenerative medicine * stem cells |full-text-url=https://sci-hub.do/10.1089/scd.2019.0116 }} {{medline-entry |title=Low-Level Radiofrequency Exposure Does Not Induce Changes in [[MSC]] Biology: An in vitro Study for the Prevention of NIR-Related Damage. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31908499 |keywords=* 169 MHz * CFU * senescence * stem cell |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927227 }} {{medline-entry |title=Macrophage migration inhibitory factor rejuvenates aged human mesenchymal stem cells and improves myocardial repair. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31881006 |mesh-terms=* Adolescent * Aged * Aged, 80 and over * Aging * Animals * Animals, Newborn * Cellular Senescence * Humans * Macrophage Migration-Inhibitory Factors * Mesenchymal Stem Cell Transplantation * Mesenchymal Stem Cells * Myocardial Infarction * Myocardium * Myocytes, Cardiac * Rats * Rats, Sprague-Dawley * Young Adult |keywords=* macrophage migration inhibitory factor * mesenchymal stem cells * myocardial infarction * rejuvenation * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949107 }} {{medline-entry |title=Influence of olive oil and its components on mesenchymal stem cell biology. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31875868 |keywords=* Aging * Cellular differentiation * Cellular niche * Mediterranean diet * Mesenchymal stem cells * Olive oil |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904865 }} {{medline-entry |title=Epigenetic Regulation of Mesenchymal Stem Cell Homeostasis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31866188 |keywords=* aging * epigenetics * fate decision * mesenchymal stem cells * pathogenesis * regeneration |full-text-url=https://sci-hub.do/10.1016/j.tcb.2019.11.006 }} {{medline-entry |title=Mesenchymal Stem Cells: Allogeneic [[MSC]] May Be Immunosuppressive but Autologous [[MSC]] Are Dysfunctional in Lupus Patients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31799252 |keywords=* dysfunction * immunoregulatory * mesenchymal stem cells * senescence * systemic lupus erythematosus |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874144 }} {{medline-entry |title=Effects of high glucose conditions on the expansion and differentiation capabilities of mesenchymal stromal cells derived from rat endosteal niche. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31752674 |mesh-terms=* Adipogenesis * Animals * Biomarkers * Bone Regeneration * Bone and Bones * Cell Differentiation * Cell Proliferation * Cells, Cultured * Cellular Senescence * Diabetes Mellitus, Type 2 * Glucose * Hyperglycemia * Male * Mesenchymal Stem Cells * Osteogenesis * Rats, Wistar |keywords=* Bone repair * Cellular senescence * Differentiation * Hyperglycaemia * Mesenchymal stromal cells; Endosteum * Type II diabetes |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873668 }} {{medline-entry |title=Autophagy inhibits the mesenchymal stem cell aging induced by D-galactose through ROS/JNK/p38 signalling. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31675454 |keywords=* ROS/JNK/p38 signalling * autophagy * mesenchymal stem cells * senescence |full-text-url=https://sci-hub.do/10.1111/1440-1681.13207 }} {{medline-entry |title=Enhancing survival, engraftment, and osteogenic potential of mesenchymal stem cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31692976 |keywords=* Anoikis * Bioactive scaffolds * Bone regeneration * Engraftment * Homing * Hypoxia * Mesenchymal stem cells * Osteogenesis * Preconditioning * Senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828596 }} {{medline-entry |title=Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31644429 |mesh-terms=* Animals * Cell Proliferation * Cells, Cultured * Cellular Senescence * Chondrocytes * Coculture Techniques * Collagenases * Etoposide * Gene Expression Regulation * Humans * Inflammation * Luciferases * Male * Mesenchymal Stem Cells * Mice * Mice, Inbred Strains * Mice, Transgenic * Osteoarthritis * Paracrine Communication |keywords=* mesenchymal stem cell * osteoarthritis * senescence * tissue homeostasis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834426 }} {{medline-entry |title=Embryonic stem cell-derived extracellular vesicles enhance the therapeutic effect of mesenchymal stem cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31660081 |mesh-terms=* Animals * Cell- and Tissue-Based Therapy * Cellular Senescence * Disease Models, Animal * Embryonic Stem Cells * Extracellular Vesicles * Humans * Insulin-Like Growth Factor I * Mesenchymal Stem Cell Transplantation * Mesenchymal Stem Cells * Mice * Mice, Inbred BALB C * Phosphatidylinositol 3-Kinases * Wounds and Injuries |keywords=* Cellular senescence * Embryonic stem cells * Extracellular vesicles * IGF1/PI3K/AKT pathway * Mesenchymal stem cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815953 }} {{medline-entry |title=Survival of aging CD264 and CD264 populations of human bone marrow mesenchymal stem cells is independent of colony-forming efficiency. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31612990 |keywords=* aging * decoy TRAIL receptor 2 (CD264) * mesenchymal stem cells * survival |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906265 }} {{medline-entry |title=Differential effects of extracellular vesicles from aging and young mesenchymal stem cells in acute lung injury. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31575829 |mesh-terms=* Acute Lung Injury * Age Factors * Animals * Disease Models, Animal * Extracellular Vesicles * Mesenchymal Stem Cell Transplantation * Mesenchymal Stem Cells * Mice * Treatment Outcome |keywords=* ARDS * acute lung injury * aging * extracellular vesicles * mesenchymal stem cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781978 }} {{medline-entry |title=Connexin43 is Dispensable for Early Stage Human Mesenchymal Stem Cell Adipogenic Differentiation But is Protective against Cell Senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31514306 |mesh-terms=* Adipogenesis * Cell Differentiation * Cellular Senescence * Connexin 43 * Gene Expression Regulation * Humans * Mesenchymal Stem Cells * Time Factors |keywords=* CRISPR-Cas9 * adipogenesis * connexin43 * gap junctional intercellular communication * mesenchymal stem cells * oculodentodigital dysplasia * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770901 }} {{medline-entry |title=Maintained Properties of Aged Dental Pulp Stem Cells for Superior Periodontal Tissue Regeneration. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31440385 |keywords=* inflammation * mesenchymal stem cells * periodontitis * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675537 }} ==MTHFR== {{medline-entry |title=One-carbon metabolism supplementation improves outcome after stroke in aged male [[MTHFR]]-deficient mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31525435 |mesh-terms=* Aging * Animals * Brain * Choline * Dietary Supplements * Male * Methylenetetrahydrofolate Reductase (NADPH2) * Mice * Mice, Inbred C57BL * Recovery of Function * Stroke * Tetrahydrofolates * Vitamin B 12 |keywords=* Cerebral ischemia * Homocysteine * Methylenetetrahydrofolate reductase * Neurodegeneration * Sensorimotor cortex * Supplementation |full-text-url=https://sci-hub.do/10.1016/j.nbd.2019.104613 }} ==MTOR== {{medline-entry |title=The roles of [[MTOR]] and miRNAs in endothelial cell senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32246301 |keywords=* Endothelium * MTOR * MicroRNAs * Senescence * Vascular aging |full-text-url=https://sci-hub.do/10.1007/s10522-020-09876-w }} {{medline-entry |title=Autophagy drives fibroblast senescence through [[MTOR]]C2 regulation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31931659 |keywords=* Autophagy * MTORC2 * myofibroblast * rapamycin * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595590 }} {{medline-entry |title=The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31795790 |keywords=* AMPK * GID * autophagy * longevity * primary cilium * ubiquitination |full-text-url=https://sci-hub.do/10.1080/15548627.2019.1695399 }} ==MTR== {{medline-entry |title=Amide proton transfer-weighted magnetic resonance imaging of human brain aging at 3 Tesla. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32269932 |keywords=* Aging * amide proton transfer imaging * biomarkers * chemical exchange saturation transfer (CEST) * molecular imaging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136735 }} ==MUC7== {{medline-entry |title=Reduced Salivary Mucin Binding and Glycosylation in Older Adults Influences Taste in an In Vitro Cell Model. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31554163 |mesh-terms=* Adolescent * Adult * Aged * Aging * Cell Line * Epithelial Cells * Female * Glycosylation * Humans * Male * Middle Aged * Mucins * N-Acetylneuraminic Acid * Plasmids * Protein Binding * Rheology * Saliva * Taste * Young Adult |keywords=* ageing * mucin * rheology * saliva * taste |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835954 }} ==MYB== {{medline-entry |title=Transcriptome profiling of postharvest shoots identifies PheNAP2- and PheNAP3-promoted shoot senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31595958 |mesh-terms=* Arabidopsis * Arabidopsis Proteins * Gene Expression Profiling * Gene Expression Regulation, Plant * Plant Leaves * Transcriptome |keywords=* Phyllostachys edulis * NAC * postharvest * regulatory factors * shoot senescence |full-text-url=https://sci-hub.do/10.1093/treephys/tpz100 }} ==MYC== {{medline-entry |title=Enhanced proliferative capacity of human preadipocytes achieved by an optimized cultivating method that induces transient activity of hTERT. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32703451 |keywords=* Adipogenesis * Adipose-derived stromal cells * Senescence * hTERT * mTesR1 |full-text-url=https://sci-hub.do/10.1016/j.bbrc.2020.06.019 }} ==MYCN== {{medline-entry |title=Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31920463 |keywords=* Aurora kinase A * Cellular senescence * MLN8237 * Neuroblastoma * Small interfering RNA |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947931 }} ==MYSM1== {{medline-entry |title=[[MYSM1]] Suppresses Cellular Senescence and the Aging Process to Prolong Lifespan. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33240758 |keywords=* DNA repair * Myb‐like, SWIRM, and MPN domains‐containing protein 1 (MYSM1) * aging * senescence * senescence‐associated secretory phenotype (SASP) |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7675055 }} ==MYT1== {{medline-entry |title=ESC-sEVs Rejuvenate Aging Hippocampal NSCs by Transferring SMADs to Regulate the [[MYT1]]-Egln3-Sirt1 Axis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33038325 |keywords=* ESC-sEVs * MYT1 * aging * hippocampal NSCs * senescence |full-text-url=https://sci-hub.do/10.1016/j.ymthe.2020.09.037 }} ==NACA== {{medline-entry |title=Age and Sex Are Strongly Correlated to the Rate and Type of Mountain Injuries Requiring Search and Rescue Missions. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31699646 |mesh-terms=* Adolescent * Adult * Aged * Aged, 80 and over * Aging * Emergency Medical Services * Female * Humans * Male * Middle Aged * Mountaineering * Rescue Work * Sex Factors * Young Adult |keywords=* MRT * NACA ICAR * SAR * injury * mechanism |full-text-url=https://sci-hub.do/10.1016/j.wem.2019.06.016 }} ==NAMPT== {{medline-entry |title=Over-expression of Nicotinamide phosphoribosyltransferase in mouse cells confers protective effect against oxidative and ER stress-induced premature senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32533606 |keywords=* ER stress * NAD+ * NAMPT * oxidative stress * premature senescence |full-text-url=https://sci-hub.do/10.1111/gtc.12794 }} {{medline-entry |title=Resistance training increases muscle NAD and NADH concentrations as well as [[NAMPT]] protein levels and global sirtuin activity in middle-aged, overweight, untrained individuals. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32369778 |keywords=* NAD + * NADH * aging * muscle * resistance training |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288928 }} {{medline-entry |title=Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase ([[NAMPT]]) and Sirtuin-1 (SIRT-1) Pathway in Obesity and T2DM: Modulation by Metformin and Macronutrient Intake. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31920356 |keywords=* NAMPT * T2DM * hNAA40 * nicotinamide phosphoribosyltransferase * obesity * senescence * sirtuin-1 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938199 }} ==NDRG2== {{medline-entry |title=[[NDRG2]] Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31947996 |mesh-terms=* Aged * Aged, 80 and over * Aging * Alzheimer Disease * Antigens, CD * Antigens, Differentiation, Myelomonocytic * Astrocytes * Brain * DNA Damage * Excitatory Amino Acid Transporter 2 * Gene Expression Regulation * Glial Fibrillary Acidic Protein * Glutamate-Ammonia Ligase * Humans * Microglia * Neurofibrillary Tangles * Tumor Suppressor Proteins * tau Proteins |keywords=* N-myc downstream regulated gene 2 (NDRG2) * ageing brain * astrocyte * neurofibrillary tangles |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982267 }} ==NDUFS8== {{medline-entry |title=Mitochondrial Complex I Mutations Predispose Drosophila to Isoflurane Neurotoxicity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32773682 |mesh-terms=* Aging * Anesthetics, Inhalation * Animals * Animals, Genetically Modified * Drosophila * Electron Transport Complex I * Isoflurane * Male * Mitochondria * Mutation * Sevoflurane |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494633 }} ==NEDD8== {{medline-entry |title=Targeting Protein Neddylation for Cancer Therapy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31898235 |mesh-terms=* Animals * Apoptosis * Autophagy * Cyclopentanes * Humans * NEDD8 Protein * Neoplasms * Pyrimidines * Ubiquitin-Protein Ligases * Ubiquitination |keywords=* Apoptosis * Autophagy * Cancer target * Inflammatory responses * Neddylation * Senescence |full-text-url=https://sci-hub.do/10.1007/978-981-15-1025-0_18 }} {{medline-entry |title=Effective targeting of the ubiquitin-like modifier [[NEDD8]] for lung adenocarcinoma treatment. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31907687 |keywords=* NEDD8 * apoptosis * cullin-RING ligases * neddylation * senescence |full-text-url=https://sci-hub.do/10.1007/s10565-019-09503-6 }} {{medline-entry |title=Pevonedistat targeted therapy inhibits canine melanoma cell growth through induction of DNA re-replication and senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31665821 |keywords=* DNA re-replication * MLN4924 * NAE-inhibitor * canine * melanoma * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473101 }} ==NEO1== {{medline-entry |title=Neogenin-1 distinguishes between myeloid-biased and balanced [i]Hoxb5[/i] mouse long-term hematopoietic stem cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31754028 |mesh-terms=* Aging * Animals * Female * Hematopoietic Stem Cell Transplantation * Hematopoietic Stem Cells * Homeodomain Proteins * Membrane Proteins * Mice * Mice, Transgenic |keywords=* Neogenin-1 * aging * hematopoietic stem cell * myeloid bias * transplantation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911217 }} ==NES== {{medline-entry |title=Mini-review: Aging of the neuroendocrine system: Insights from nonhuman primate models. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31891735 |keywords=* Aging * Neuroendocrine system * Nonhuman primate |full-text-url=https://sci-hub.do/10.1016/j.pnpbp.2019.109854 }} ==NFKB1== {{medline-entry |title=[[NFKB1]] gene single-nucleotide polymorphisms: implications for graft-versus-host disease in allogeneic hematopoietic stem cell transplantation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32002656 |mesh-terms=* Adult * Allografts * Disease-Free Survival * Female * Graft vs Host Disease * Hematopoietic Stem Cell Transplantation * Humans * Male * Middle Aged * NF-kappa B p50 Subunit * Pilot Projects * Polymorphism, Single Nucleotide * Survival Rate |keywords=* Allogeneic hematopoietic stem cell transplantation * Cellular senescence * Graft-versus-host disease * NFKB1 gene * Senescence-associated secretory phenotype * Single-nucleotide polymorphism |full-text-url=https://sci-hub.do/10.1007/s00277-020-03935-5 }} ==NGF== {{medline-entry |title=Dietary fish hydrolysate supplementation containing n-3 LC-PUFAs and peptides prevents short-term memory and stress response deficits in aged mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32976934 |keywords=* Aging * Anxiety-like behaviour * Cognitive decline * Hydrolysate * Low molecular weight peptides * Marine by-products * Memory * Navigation strategies * Neuroinflammation * Stress response * n-3 Long chain polyunsaturated fatty acids (n-3 LC-PUFAs) |full-text-url=https://sci-hub.do/10.1016/j.bbi.2020.09.022 }} {{medline-entry |title=Imbalance of nerve growth factor metabolism in aging women with overactive bladder syndrome. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32870355 |keywords=* Aging female * MMP-7 * MMP-9 * Nerve growth factor * Overactive bladder * proNGF |full-text-url=https://sci-hub.do/10.1007/s00345-020-03422-6 }} {{medline-entry |title=Parity Attenuates Intraepithelial Corneal Sensory Nerve Loss in Female Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32708332 |keywords=* aging * corneal epithelial cell proliferation * corneal sensitivity * corneal sensory nerves * mouse * parity * pregnancy |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7404034 }} {{medline-entry |title=Cholinergic System and [[NGF]] Receptors: Insights from the Brain of the Short-Lived Fish [i]Nothobranchius furzeri[/i]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32575701 |keywords=* NTRK1/NTRKA * aging * cholinergic system * fish * p75/NGFR |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7348706 }} {{medline-entry |title=Retrograde axonal transport of BDNF and pro[[NGF]] diminishes with age in basal forebrain cholinergic neurons. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31574357 |mesh-terms=* Aging * Alzheimer Disease * Axonal Transport * Brain-Derived Neurotrophic Factor * Cholinergic Neurons * Humans * Nerve Growth Factor * Prosencephalon |keywords=* Alzheimer's disease * Axonal transport * Basal forebrain * Neurodegeneration * Neurotrophins * Trk receptors |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2019.07.018 }} {{medline-entry |title=C-SH2 point mutation converts p85β regulatory subunit of phosphoinositide 3-kinase to an anti-aging gene. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31481652 |mesh-terms=* Aging * Animals * Blood Glucose * Class I Phosphatidylinositol 3-Kinases * Class Ia Phosphatidylinositol 3-Kinase * Female * Forkhead Transcription Factors * Insulin * Male * Mice * Mice, Inbred C57BL * Mice, Transgenic * Nerve Growth Factor * Oxidative Stress * PC12 Cells * Platelet-Derived Growth Factor * Point Mutation * Proto-Oncogene Proteins c-akt * Rats * src Homology Domains |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722097 }} ==NHS== {{medline-entry |title=Telomerase Activation to Reverse Immunosenescence in Elderly Patients With Acute Coronary Syndrome: Protocol for a Randomized Pilot Trial. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32965237 |keywords=* acute coronary syndrome * coronary heart disease * immunosenescence * telomerase activator |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7542409 }} {{medline-entry |title=Factors associated with COVID-19-related death using OpenSAFELY. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32640463 |mesh-terms=* Adolescent * Adult * African Continental Ancestry Group * Age Distribution * Age Factors * Aged * Aged, 80 and over * Aging * Asian Continental Ancestry Group * Asthma * Betacoronavirus * COVID-19 * Cohort Studies * Coronavirus Infections * Diabetes Mellitus * Female * Humans * Hypertension * Male * Middle Aged * Pandemics * Pneumonia, Viral * Proportional Hazards Models * Risk Assessment * SARS-CoV-2 * Sex Characteristics * Smoking * State Medicine * Young Adult |full-text-url=https://sci-hub.do/10.1038/s41586-020-2521-4 }} {{medline-entry |title=Advanced ophthalmic nurse practitioners: the potential to improve outcomes for older people with cataracts. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32548985 |keywords=* advanced practice * gerontology * older people * patient outcomes * patients * practice development * professional * professional issues * quality of life |full-text-url=https://sci-hub.do/10.7748/nop.2020.e1229 }} {{medline-entry |title=Patient Satisfaction in the Spanish National Health Service: Partial Least Squares Structural Equation Modeling. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31817147 |mesh-terms=* Cross-Sectional Studies * Gross Domestic Product * Health Care Rationing * Health Expenditures * Humans * Latent Class Analysis * Least-Squares Analysis * Life Expectancy * Patient Safety * Patient Satisfaction * Spain * State Medicine |keywords=* National Health Service * health policy * partial least squares structural equation modeling (PLS-SEM) * patient satisfaction * quality of healthcare |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950388 }} {{medline-entry |title=Heart failure with preserved ejection fraction (HFpEF) pathophysiology study (IDENTIFY-HF): does increased arterial stiffness associate with HFpEF, in addition to ageing and vascular effects of comorbidities? Rationale and design. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31748285 |mesh-terms=* Aged * Aged, 80 and over * Aging * Biomarkers * Comorbidity * Diabetes Mellitus * Echocardiography * Exercise Tolerance * Female * Heart Failure * Heart Ventricles * Humans * Hypertension * Male * Observational Studies as Topic * Prospective Studies * Pulse Wave Analysis * Research Design * Stroke Volume * Vascular Stiffness |keywords=* arterial stiffness * comorbidities * heart failure with preserved ejection fraction * pathophysiology |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886989 }} {{medline-entry |title=Challenges to concordance: theories that explain variations in patient responses. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31604052 |mesh-terms=* Aging * Benchmarking * Communication Barriers * Community Health Nursing * Humans * Nurse-Patient Relations * State Medicine * United Kingdom |keywords=* Concordance * Decision making * Person-centred care * Psychological theories * Self-management |full-text-url=https://sci-hub.do/10.12968/bjcn.2019.24.10.466 }} {{medline-entry |title=Optimism is associated with exceptional longevity in 2 epidemiologic cohorts of men and women. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31451635 |mesh-terms=* Adult * Aged * Aged, 80 and over * Aging * Female * Health Behavior * Humans * Logistic Models * Longevity * Longitudinal Studies * Male * Middle Aged * Odds Ratio |keywords=* aging * longevity * longitudinal study * optimism * psychological well-being |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744861 }} ==NKAP== {{medline-entry |title=[[NKAP]] Regulates Senescence and Cell Death Pathways in Hematopoietic Progenitors. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31632967 |keywords=* NKAP * apoptosis * cyclin dependent kinase inhibitor * hematopoiesis * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783958 }} ==NKX6-1== {{medline-entry |title=The dynamic methylome of islets in health and disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31500828 |mesh-terms=* Animals * Cell Differentiation * DNA Methylation * Diabetes Mellitus, Type 2 * Epigenome * Humans * Insulin-Secreting Cells |keywords=* Aging * Beta cells * DNA methylation * Endocrine pancreas * Epigenetics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768570 }} ==NLRC4== {{medline-entry |title=Hyperglycemia-induced inflamm-aging accelerates gingival senescence via [[NLRC4]] phosphorylation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31676687 |mesh-terms=* Aging * Animals * Apoptosis Regulatory Proteins * Blotting, Western * Calcium-Binding Proteins * Cellular Senescence * Clustered Regularly Interspaced Short Palindromic Repeats * Gingiva * Glucose * Hyperglycemia * Immunohistochemistry * Inflammation * Interferon Regulatory Factors * Male * Mice * Mice, Inbred C57BL * RAW 264.7 Cells * Signal Transduction |keywords=* NLRC4 * SASP * aging * cellular senescence * diabetes * gingiva * hyperglycemia * inflamm-aging * inflammasome * inflammation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901307 }} ==NLRP12== {{medline-entry |title=Persistent DNA damage-induced [[NLRP12]] improves hematopoietic stem cell function. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32434992 |keywords=* Aging * DNA repair * Hematology * Hematopoietic stem cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259522 }} ==NLRP3== {{medline-entry |title=Innate and Adaptive Immunity in Aging and Longevity: The Foundation of Resilience. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33269094 |keywords=* adaptive immunity * aging * innate immunity * longevity * resilience |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673842 }} {{medline-entry |title=TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33113366 |keywords=* CHIP * IL-1β * TET2 * adipose tissue * aging * clonal hematopoiesis * diabetes * insulin resistance * obesity * somatic mutations |full-text-url=https://sci-hub.do/10.1016/j.celrep.2020.108326 }} {{medline-entry |title=Repeated propofol exposure-induced neuronal damage and cognitive impairment in aged rats by activation of NF-κB pathway and [[NLRP3]] inflammasome. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33115643 |keywords=* Aging * Apoptosis * NOD-like receptor protein 3 inflammasome * Neuroinflammation * Postoperative cognitive dysfunction * Propofol |full-text-url=https://sci-hub.do/10.1016/j.neulet.2020.135461 }} {{medline-entry |title=A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33066043 |keywords=* ASC and pannexin 1 * MYC G4-quadruplex stabilizer * NLRP3 * caspase 1 * endoplasmic reticulum stress * gasdermin D * inflammasome * pyroptosis * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650714 }} {{medline-entry |title=Interleukin-1β Drives Cellular Senescence of Rat Astrocytes Induced by Oligomerized Amyloid β Peptide and Oxidative Stress. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33013631 |keywords=* Alzheimer's disease * amyloid β * astrocyte * interleukin-1β * neuroinflammation * senescence * tau |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493674 }} {{medline-entry |title=Mechanisms of [[NLRP3]] priming in inflammaging and age related diseases. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32883606 |keywords=* Aging * Inflammaging * Inflammasome * NLRP3 * Priming * Senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7571497 }} {{medline-entry |title=Lamivudine Inhibits [i]Alu[/i] RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-senescence Activities. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32855848 |keywords=* NLRP3 inflammasome * age-related macular degeneration * lamivudine * retinal pigment epithelium * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422901 }} {{medline-entry |title=The [[NLRP3]] Inflammasome: Metabolic Regulation and Contribution to Inflammaging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32751530 |keywords=* NLRP3 inflammasome * aging * inflammation * metabolism * mitochondria |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463618 }} {{medline-entry |title=Aging aggravated liver ischemia and reperfusion injury by promoting STING-mediated [[NLRP3]] activation in macrophages. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32666684 |keywords=* aging * and reperfusion injury * leucine-rich repeat containing protein 3 * liver ischemia * macrophage immune response * nucleotide-binding domain * stimulator of interferon genes |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431827 }} {{medline-entry |title=Targeting [[NLRP3]] Inflammasome Reduces Age-Related Experimental Alveolar Bone Loss. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32531176 |keywords=* aging * inflammasomes * inflammation * macrophages * osteoclasts * periodontitis |full-text-url=https://sci-hub.do/10.1177/0022034520933533 }} {{medline-entry |title=Korean Red Ginseng Suppresses the Expression of Oxidative Stress Response and [[NLRP3]] Inflammasome Genes in Aged C57BL/6 Mouse Ovaries. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32331214 |keywords=* Korean ginseng extract * NLRP3 inflammasome * aging * ovary * oxidative stress response * subfertility |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231237 }} {{medline-entry |title=Cepharanthine promotes the effect of dexmedetomidine on the deposition of β-amyloid in the old age of the senile dementia rat model by regulating inflammasome expression. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32337948 |mesh-terms=* Aging * Animals * Benzylisoquinolines * Brain * Dexmedetomidine * Inflammasomes * Inflammation * Male * Mitochondria * Oxidative Stress * Rats, Sprague-Dawley * Reactive Oxygen Species |keywords=* dementia * dexmedetomidine * inflammasomes * β-amyloid * cepharanthine |full-text-url=https://sci-hub.do/10.5114/fn.2019.89855 }} {{medline-entry |title=Ginsenoside Rg1 ameliorates glomerular fibrosis during kidney aging by inhibiting NOX4 and [[NLRP3]] inflammasome activation in SAMP8 mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32114413 |keywords=* Ginsenoside Rg1 * Kidney aging * NADPH oxidase 4 (NOX4) * NLRP3 inflammasome * Renal fibrosis |full-text-url=https://sci-hub.do/10.1016/j.intimp.2020.106339 }} {{medline-entry |title=Blockade of the [[NLRP3]] inflammasome improves metabolic health and lifespan in obese mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31975052 |keywords=* Aging * Autophagy * High-fat diet * Longevity * NLRP3 inflammasome * Obesity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206474 }} {{medline-entry |title=Autophagy and [[NLRP3]] inflammasome crosstalk in neuroinflammation in aged bovine brains. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31903559 |keywords=* NLRP3 inflammasome * aging * autophagy * bovine * immunosenescence * neuroinflammation |full-text-url=https://sci-hub.do/10.1002/jcp.29426 }} {{medline-entry |title=[[NLRP3]] Inflammasome Inhibition by MCC950 in Aged Mice Improves Health via Enhanced Autophagy and PPARα Activity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31603987 |keywords=* Aging * Autophagy * MCC950 * NLRP3 inflammasome * PPARα |full-text-url=https://sci-hub.do/10.1093/gerona/glz239 }} {{medline-entry |title=[[NLRP3]] inflammasome suppression improves longevity and prevents cardiac aging in male mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31625260 |keywords=* NLRP3-inflammasome * autophagy * cardiac aging * longevity * morbidity * mortality |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974709 }} {{medline-entry |title=Reduced NRF2 expression suppresses endothelial progenitor cell function and induces senescence during aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31494646 |mesh-terms=* Aging * Animals * Cellular Senescence * Endothelial Progenitor Cells * Mice * NF-E2-Related Factor 2 * NF-kappa B * NLR Family, Pyrin Domain-Containing 3 Protein * Neovascularization, Physiologic * Oxidative Stress |keywords=* NLRP3 inflammasome * NRF2 * aging * endothelial progenitor cells * oxidative stress |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6756903 }} {{medline-entry |title=Effect of Aging on Taurine Transporter (TauT) Expression in the Mouse Brain Cortex. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31468381 |mesh-terms=* Aging * Animals * Brain * Membrane Glycoproteins * Membrane Transport Proteins * Mice * Mice, Inbred C57BL * Taurine |keywords=* Age-related diseases * Glycine Transporter (GLYT) * NLRP3 * Taurine Transporter (TauT) |full-text-url=https://sci-hub.do/10.1007/978-981-13-8023-5_1 }} ==NMI== {{medline-entry |title=Age-Dependent Control of Shoulder Muscles During a Reach-and-Lift Task. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31825888 |keywords=* activity of daily living * aging * functional connectivity * motor variability * muscle fatigue |full-text-url=https://sci-hub.do/10.1123/japa.2019-0055 }} ==NMS== {{medline-entry |title=Uncontrolled Diabetes as an Associated Factor with Dynapenia in Adults Aged 50 Years or Older: Sex Differences. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31665234 |keywords=* Aging * Dynapenia * Glycated hemoglobin * Hyperglycemia * Neuromuscular strength |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243578 }} ==NMUR1== {{medline-entry |title=[Medicinal Chemistry Focused on Mid-sized Peptides Derived from Biomolecules]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31685733 |mesh-terms=* Aging * Chemistry, Pharmaceutical * Drug Discovery * Humans * Life Style * Molecular Targeted Therapy * Muscle Weakness * Muscular Atrophy * Myostatin * Neuropeptides * Obesity * Peptides * Receptors, Neurotransmitter * Structure-Activity Relationship |keywords=* myostatin inhibitor * neuromedin U receptor-selective agonist * peptide |full-text-url=https://sci-hub.do/10.1248/yakushi.19-00149 }} ==NNT== {{medline-entry |title=Yoga, Health-Related Quality of Life and Mental Well-Being: A Re-analysis of a Meta-analysis Using the Quality Effects Model. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31814012 |keywords=* Outcomes * Physical activity * Successful aging * Systematic review |full-text-url=https://sci-hub.do/10.1093/gerona/glz284 }} {{medline-entry |title=Statins After Myocardial Infarction in the Oldest: A Cohort Study in the Clinical Practice Research Datalink Database. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31647578 |mesh-terms=* Aged * Aged, 80 and over * Case-Control Studies * Databases, Factual * Female * Humans * Hydroxymethylglutaryl-CoA Reductase Inhibitors * Male * Myocardial Infarction * Proportional Hazards Models * Retrospective Studies * Risk Assessment * Secondary Prevention * Stroke |keywords=* geriatrics * myocardial infarction * secondary prevention * statin * time varying |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028025 }} ==NOP10== {{medline-entry |title=Pseudouridylation defect due to [i]DKC1[/i] and [i][[NOP10]][/i] mutations causes nephrotic syndrome with cataracts, hearing impairment, and enterocolitis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32554502 |mesh-terms=* Animals * Cataract * Cell Cycle Proteins * Child * Enterocolitis * Female * Genetic Predisposition to Disease * Hearing Loss, Sensorineural * Humans * Longevity * Male * Models, Molecular * Molecular Dynamics Simulation * Mutation * Nephrotic Syndrome * Nuclear Proteins * Pedigree * Protein Conformation * RNA, Ribosomal * Ribonucleoproteins, Small Nucleolar * Zebrafish |keywords=* H/ACA snoRNP * pediatrics * pseudouridylation * rRNA * telomere |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334496 }} ==NOS1== {{medline-entry |title=Prepubertal overexposure to manganese induce precocious puberty through GABA receptor/nitric oxide pathway in immature female rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31711775 |mesh-terms=* Aging * Animals * Chlorides * Endocrine Disruptors * Female * Gonadotropin-Releasing Hormone * Manganese Compounds * Neurons * Nitric Oxide * Ovary * Preoptic Area * Rats * Rats, Sprague-Dawley * Receptors, GABA-A * Sexual Maturation * Signal Transduction * Uterus * Weaning |keywords=* GABA(A)R * GnRH * Manganese * Nitric oxide * Precocious puberty |full-text-url=https://sci-hub.do/10.1016/j.ecoenv.2019.109898 }} ==NOS3== {{medline-entry |title=Application of Oxidative Stress to a Tissue-Engineered Vascular Aging Model Induces Endothelial Cell Senescence and Activation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32455928 |keywords=* endothelial cells * oxidative stress * senescence * tissue-engineered blood vessel * vascular smooth muscle cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290800 }} ==NOTCH1== {{medline-entry |title=[How Does Aging Contribute to Cancer?] |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33130684 |mesh-terms=* Aged * Aging * Carcinogenesis * Esophageal Neoplasms * Humans * Mutation }} {{medline-entry |title=H19 is not hypomethylated or upregulated with age or sex in the aortic valves of mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31609547 |mesh-terms=* Aging * Animals * Aortic Valve * Aortic Valve Stenosis * Calcinosis * DNA Methylation * Female * Male * Mice * Mice, Inbred C57BL * RNA, Long Noncoding * Sex Factors * Up-Regulation |keywords=* H19 * age * calcific aortic valve disease * epigenetics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778597 }} ==NOTCH4== {{medline-entry |title=Age-dependent autophagy induction after injury promotes axon regeneration by limiting NOTCH. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31920157 |keywords=* Aging * DLK * LC3 * Notch signaling * autophagy * axon injury * axon regeneration |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595581 }} ==NOX4== {{medline-entry |title=Sestrin2 Attenuates Cellular Senescence by Inhibiting NADPH Oxidase 4 Expression. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33227845 |keywords=* NOX4 * Reactive oxygen species * Senescence * Sestrin2 |full-text-url=https://sci-hub.do/10.4235/agmr.20.0051 }} ==NPM1== {{medline-entry |title=Flow cytometric identification and cell-line establishment of macrophages in naked mole-rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31784606 |mesh-terms=* Animals * Cell Line * Cell Proliferation * Cell Separation * Culture Media * Flow Cytometry * Longevity * Macrophage Colony-Stimulating Factor * Macrophages * Mole Rats * Recombinant Proteins |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884578 }} ==NPR1== {{medline-entry |title=The [[NPR1]]-WRKY46-WRKY6 signaling cascade mediates probenazole/salicylic acid-elicited leaf senescence in Arabidopsis thaliana. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33270345 |keywords=* Leaf senescence * NPR1 * Probenazole * Salicylic acid * WRKY46 * WRKY6 |full-text-url=https://sci-hub.do/10.1111/jipb.13044 }} {{medline-entry |title=Loss of proton/calcium exchange 1 results in the activation of plant defense and accelerated senescence in Arabidopsis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32540002 |keywords=* Early senescence * H(+)/Ca(2+)exchanger 1 * Plant defense * Salicylic acid * Scopoletin |full-text-url=https://sci-hub.do/10.1016/j.plantsci.2020.110472 }} ==NPW== {{medline-entry |title=Novel information processing at work across time is associated with cognitive change in later life: A 14-year longitudinal study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32309980 |mesh-terms=* Aged * Aging * Cognition * Cognitive Aging * Cognitive Dysfunction * Employment * Female * Humans * Longitudinal Studies * Male * Middle Aged * Retirement * Time |full-text-url=https://sci-hub.do/10.1037/pag0000468 }} ==NPY== {{medline-entry |title=Neuropeptide Y Enhances Progerin Clearance and Ameliorates the Senescent Phenotype of Human Hutchinson-Gilford Progeria Syndrome Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32012215 |keywords=* Autophagy * Caloric restriction mimetic * Cellular senescence * Human aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243588 }} {{medline-entry |title=Effects of rikkunshito supplementation on resistance to oxidative stress and lifespan in mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31855319 |mesh-terms=* Animals * Caloric Restriction * Dietary Supplements * Drugs, Chinese Herbal * Female * Ghrelin * Longevity * Male * Mice * Mice, Knockout * Oxidative Stress |keywords=* calorie restriction * ghrelin * longevity * metabolism * oxidative stress |full-text-url=https://sci-hub.do/10.1111/ggi.13848 }} ==NRAS== {{medline-entry |title=Senescent cholangiocytes release extracellular vesicles that alter target cell phenotype via the epidermal growth factor receptor. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32558183 |keywords=* biliary epithelial cell * cellular senescence * extracellular vesicles * primary sclerosing cholangitis * senescence-associated secretory phenotype |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7669612 }} {{medline-entry |title=STAT3 Relays a Differential Response to Melanoma-Associated [i][[NRAS]][/i] Mutations. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31906480 |keywords=* NRAS * STAT3 * melanoma * mutation * oncogene-induced senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016650 }} {{medline-entry |title=Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31703632 |mesh-terms=* Animals * Apoptosis * Carcinogenesis * Cell Differentiation * DNA (Cytosine-5-)-Methyltransferases * Disease Models, Animal * Disease Progression * Gene Expression Regulation, Neoplastic * Gene Knock-In Techniques * Leukemia, Myeloid, Acute * Longevity * Mice * Mice, Inbred C57BL * Mice, Transgenic * Monomeric GTP-Binding Proteins * Mutation * Phenotype * Pilot Projects * Proto-Oncogene Proteins c-myc * RNA-Seq * Transcription, Genetic |keywords=* Acute myeloid leukemia * DNMT3A mutation * Myc activation * Nras G12D |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842226 }} ==NRL== {{medline-entry |title=Development of a cyclophosphamide stress test to predict resilience to aging in mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32613492 |keywords=* Aging mice * Cyclophosphamide * Neutrophil lymphocyte ratio * Resilience to aging * Stress test * WBC count |full-text-url=https://sci-hub.do/10.1007/s11357-020-00222-z }} ==NRM== {{medline-entry |title=Association between Clonal Hematopoiesis and Late Nonrelapse Mortality after Autologous Hematopoietic Cell Transplantation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31445185 |mesh-terms=* Adult * Age Factors * Aged * Aging * Autografts * Female * Hematopoiesis * Hematopoietic Stem Cell Transplantation * Humans * Lymphoma, Non-Hodgkin * Male * Middle Aged * Multiple Myeloma * Retrospective Studies |keywords=* Autologous * Clonal hematopoiesis * Lymphoma * Multiple myeloma * Nonrelapse mortality * Survivors * Transplantation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192097 }} ==NSF== {{medline-entry |title=Effects of air pollution on children from a socioecological perspective. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31727016 |mesh-terms=* Air Pollution * Child Mortality * Child, Preschool * Environment * Humans * Income * Infant * Life Expectancy * Retrospective Studies * Socioeconomic Factors * Sociological Factors |keywords=* Deaths of children under age 5 * Electrification rates * Income * Inequality in life expectancy * Natural resource depletion * Non-solid fuel * Outdoor and indoor air pollution * Socioecological perspective |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857293 }} ==NT5E== {{medline-entry |title=The [[NT5E]] gene variant strongly affects the degradation rate of inosine 5'-monophosphate under postmortem conditions in Japanese Black beef. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31401370 |mesh-terms=* 5'-Nucleotidase * Animals * Cattle * Diaphragm * Food Handling * Inosine Monophosphate * Muscle, Skeletal * Polymorphism, Single Nucleotide * Postmortem Changes * Red Meat * Taste |keywords=* Inosine 5′-monophosphate * Japanese Black beef * Meat quality * NT5E * Postmortem aging |full-text-url=https://sci-hub.do/10.1016/j.meatsci.2019.107893 }} ==NTHL1== {{medline-entry |title=Mitochondrial base excision repair positively correlates with longevity in the liver and heart of mammals. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31970600 |keywords=* AP endonuclease * Aging * DNA glycosylases * DNA repair * Mitochondria |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205949 }} ==NUCB2== {{medline-entry |title=Ontogenetic Pattern Changes of Nucleobindin-2/Nesfatin-1 in the Brain and Intestinal Bulb of the Short Lived African Turquoise Killifish. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31906085 |keywords=* Nesf-1 * Nothobranchius furzeri * aging * brain-gut axis * vertebrate |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019235 }} ==OGA== {{medline-entry |title=NPGPx-Mediated Adaptation to Oxidative Stress Protects Motor Neurons from Degeneration in Aging by Directly Modulating O-GlcNAcase. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31747588 |mesh-terms=* Aging * Amyotrophic Lateral Sclerosis * Animals * Female * Humans * Mice * Mice, Mutant Strains * Motor Neurons * Muscle Denervation * Oxidative Stress * Paralysis * beta-N-Acetylhexosaminidases |keywords=* ALS * NPGPx * O-GlcNAcylation * OGA * aging * motor neuron * oxidative stress |full-text-url=https://sci-hub.do/10.1016/j.celrep.2019.10.053 }} ==OGG1== {{medline-entry |title=Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31783583 |mesh-terms=* Adult * Aged * Aged, 80 and over * Aging * DNA, Mitochondrial * Female * Homeostasis * Humans * Inflammation * Iron * Male * Mitochondria, Muscle * Quadriceps Muscle * Young Adult |keywords=* ZIP * ferritin * hepcidin * inflammation * iron overload * mitochondrial dysfunction * mtDNA * muscle aging * physical performance * transferrin |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953082 }} ==OGT== {{medline-entry |title=ELT-2 promotes O-GlcNAc transferase [[OGT]]-1 expression to modulate Caenorhabditis elegans lifespan. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32628333 |keywords=* Caenorhabditis elegans * GATA factor ELT-2 * OGT-1 * lifespan |full-text-url=https://sci-hub.do/10.1002/jcb.29817 }} {{medline-entry |title=Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31588002 |mesh-terms=* Acetylglucosamine * Acylation * Aging * Animals * Cognition * Male * Mice * Mice, Knockout * N-Acetylglucosaminyltransferases |keywords=* O-GlcNAcylation * OGT * aging * brain * cognition * hippocampus * rejuvenation * synaptic plasticity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199460 }} ==OSM== {{medline-entry |title=Age Differences in Sexual Minority Stress and the Importance of Friendship in Later Life. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143546 |keywords=* LGBT * Sexual minorities * cohort differences * discrimination * friendship aging * internalized homonegativity * minority stress * outness * social support |full-text-url=https://sci-hub.do/10.1080/07317115.2020.1836107 }} ==OTC== {{medline-entry |title=Age and growth of stocked juvenile Shoal Bass in a tailwater: Environmental variation and accuracy of daily age estimates. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31644599 |mesh-terms=* Aging * Animals * Bass * Ecosystem * Environmental Monitoring * Population Dynamics * Reproduction * Rivers |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6808449 }} ==P2RY12== {{medline-entry |title=Potential caveats of putative microglia-specific markers for assessment of age-related cerebrovascular neuroinflammation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33261619 |keywords=* Aging * Brain infiltrating myeloid cells * CD45 * Cerebral amyloid angiopathy * Microglia * Neuroinflammation * P2RY12 * Stroke * Tmem119 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7709276 }} {{medline-entry |title=Microglial changes in the early aging stage in a healthy retina and an experimental glaucoma model. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32958210 |keywords=* Aging * CD68 * Glaucoma * Iba-1 * Inflammation * MHCII * Microglia * Mouse * Ocular hypertension * P2RY12 * Retina |full-text-url=https://sci-hub.do/10.1016/bs.pbr.2020.05.024 }} {{medline-entry |title=Patterns of Expression of Purinergic Receptor [[P2RY12]], a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31968618 |mesh-terms=* Aging * Alzheimer Disease * Biomarkers * Brain * Humans * Immunohistochemistry * Inflammation * Macrophages * Microglia * Phenotype * Plaque, Amyloid * Receptors, Purinergic P2Y2 |keywords=* Alzheimer’s disease * activation phenotypes * amyloid * immunohistochemistry * microglia * neuroinflammation * temporal cortex |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014248 }} ==P4HA2== {{medline-entry |title=Expanding the Phenotypic and Genotypic Landscape of Nonsyndromic High Myopia: A Cross-Sectional Study in 731 Chinese Patients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31560770 |mesh-terms=* Adolescent * Adult * Aged * Aged, 80 and over * Aging * Asian Continental Ancestry Group * Axial Length, Eye * Child * Child, Preschool * China * Cross-Sectional Studies * DNA Mutational Analysis * Female * Genetic Association Studies * Genotype * Humans * Male * Middle Aged * Myopia, Degenerative * Phenotype * Retinal Diseases * Vision, Low * Young Adult |full-text-url=https://sci-hub.do/10.1167/iovs.19-27921 }} ==P4HA3== {{medline-entry |title=Age-associated genes in human mammary gland drive human breast cancer progression. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32539762 |mesh-terms=* Adult * Age Factors * Aged * Aged, 80 and over * Animals * Biomarkers, Tumor * Breast * Breast Neoplasms * Disease Progression * Dyneins * Female * Gene Expression Regulation, Neoplastic * Heterografts * Humans * Mice * Mice, Inbred NOD * Mice, SCID * Middle Aged * Procollagen-Proline Dioxygenase * Prognosis * Survival Rate * Tumor Cells, Cultured |keywords=* ALX4 * Aging * Breast cancer * DYNLT3 * Gene expression * P4HA3 * Relapse-free survival * Transcriptomics * Tumor progression |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294649 }} ==PAH== {{medline-entry |title=Changes in light absorption by brown carbon in soot particles due to heterogeneous ozone aging in a smog chamber. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32771846 |mesh-terms=* Aerosols * Biomass * Carbon * Ozone * Smog * Soot |keywords=* Absorption Ångström exponent * Brown carbon * Light absorption * Ozone aging * Soot particles |full-text-url=https://sci-hub.do/10.1016/j.envpol.2020.115273 }} {{medline-entry |title=Factors associated with pulmonary arterial hypertension ([[PAH]]) in systemic sclerosis (SSc). |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32659476 |mesh-terms=* Aging * Humans * Natriuretic Peptide, Brain * Pulmonary Arterial Hypertension * Risk Factors * Scleroderma, Systemic |full-text-url=https://sci-hub.do/10.1016/j.autrev.2020.102602 }} {{medline-entry |title=Potentially Avoidable Hospitalization among Long-Term Care Insurance Beneficiaries with Dementia. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32316707 |keywords=* Aging * Dementia * Long-Term Care |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509129 }} ==PAM== {{medline-entry |title=Relationship between patient activation measurement and self-rated health in patients with chronic diseases. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33148185 |keywords=* Aging population * Chronic diseases * Patient activation measurement * Primary health care * Self-rated health |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643260 }} {{medline-entry |title=Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33068001 |keywords=* GABA * aging * cognition * neurotrophic effect * positive allosteric modulator |full-text-url=https://sci-hub.do/10.1093/cercor/bhaa310 }} {{medline-entry |title=The ratio of prematurely aging to non-prematurely aging mice cohabiting, conditions their behavior, immunity and lifespan. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32330742 |mesh-terms=* Aging * Aging, Premature * Animals * Behavior, Animal * Female * Housing, Animal * Longevity * Lymphocytes * Macrophages * Mice * Oxidative Stress * Social Environment |keywords=* Behavior * Immunity * Mean lifespan * Prematurely aging mice * Social environmental strategy |full-text-url=https://sci-hub.do/10.1016/j.jneuroim.2020.577240 }} ==PAX8== {{medline-entry |title=Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31518338 |mesh-terms=* Aging * Animals * Fatty Liver * Insulin Resistance * Liver * Liver Neoplasms * Male * Mice * Mice, Knockout * PAX8 Transcription Factor * Thyroid Hormones |keywords=* glucose metabolism * healthspan * hyperthyroidism * hypothyroidism * lifespan * thyroid hormones |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781991 }} ==PBX1== {{medline-entry |title=Internalization of the TAT-[[PBX1]] fusion protein significantly enhances the proliferation of human hair follicle-derived mesenchymal stem cells and delays their senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32436118 |keywords=* AKT * Hair follicle mesenchymal stem cells * PBX1 * Protein purification * Senescence * TAT |full-text-url=https://sci-hub.do/10.1007/s10529-020-02909-x }} ==PC== {{medline-entry |title=Blended home-based exercise and dietary protein in community-dwelling older adults: a cluster randomized controlled trial. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33103379 |keywords=* Aging * Behaviour change * Physical functioning * Protein * Sarcopenia * e-Health |full-text-url=https://sci-hub.do/10.1002/jcsm.12634 }} {{medline-entry |title=Right ventricular diastolic function in aging: a head-to-head comparison between phase-contrast MRI and Doppler echocardiography. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32980983 |keywords=* Aging * Diastolic function * Phase-contrast MRI * Right ventricle |full-text-url=https://sci-hub.do/10.1007/s10554-020-02040-y }} {{medline-entry |title=Pulse Width and Implantable Pulse Generator Longevity in Pallidal Deep Brain Stimulation for Dystonia: A Population-Based Comparative Effectiveness Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32668433 |keywords=* Deep brain stimulation * Dystonia * Globus pallidus internus * Pulse generator longevity * Pulse width |full-text-url=https://sci-hub.do/10.1159/000508794 }} {{medline-entry |title=Gemcitabine plus nab-paclitaxel with initial dose reduction for older patients with advanced pancreatic cancer. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32576518 |keywords=* Adverse events * Chemotherapy * Gemcitabine * Geriatrics * Nab-paclitaxel * Pancreatic cancer |full-text-url=https://sci-hub.do/10.1016/j.jgo.2020.06.017 }} {{medline-entry |title=Protective effects of 17-β-oestradiol and phytoestrogen on age-induced oxidative stress and inhibition of surfactant synthesis in rat type II pneumocytes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32314935 |keywords=* 17-β-Oestradiol * aging * oxidative stress * phytoestrogen * surfactant * type ii pneumocytes |full-text-url=https://sci-hub.do/10.1080/09637486.2020.1757044 }} {{medline-entry |title=Pacing During 200-m Competitive Masters Swimming. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32271289 |mesh-terms=* Adult * Age Factors * Aged * Aged, 80 and over * Aging * Athletes * Athletic Performance * Competitive Behavior * Female * Humans * Male * Middle Aged * Sex Factors * Swimming |full-text-url=https://sci-hub.do/10.1519/JSC.0000000000003621 }} {{medline-entry |title=Prostate cancer in Pennsylvania: The role of older age at diagnosis, aggressiveness, and environmental risk factors on treatment and mortality using data from the Pennsylvania Cancer Registry. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32212232 |keywords=* aging * behavioral risk factors * geriatric oncology * healthy aging * prostate cancer survivorship |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221418 }} {{medline-entry |title=Extracranial versus intracranial hydro-hemodynamics during aging: a [[PC]]-MRI pilot cross-sectional study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31931818 |mesh-terms=* Aged * Aged, 80 and over * Brain * Cerebral Ventricles * Cerebrospinal Fluid * Cerebrovascular Circulation * Cross-Sectional Studies * Female * Hemodynamics * Humans * Magnetic Resonance Imaging * Male * Middle Aged |keywords=* Aging * Arterial cerebral blood flow * CSF flow * PC-MRI * Pulsatility * Venous cerebral blood flow |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958565 }} {{medline-entry |title=Age-specific health-related quality of life in disease-free long-term prostate cancer survivors versus male population controls-results from a population-based study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31736000 |mesh-terms=* Adult * Age Factors * Aged * Aging * Cancer Survivors * Case-Control Studies * Disease-Free Survival * Germany * Humans * Male * Middle Aged * Prostatic Neoplasms * Quality of Life * Surveys and Questionnaires * Young Adult |keywords=* Health-related quality of life * Long-term survivor * Population-based * Prostate cancer |full-text-url=https://sci-hub.do/10.1007/s00520-019-05120-5 }} {{medline-entry |title=Cross-Linked Polyphenol-Based Drug Nano-Self-Assemblies Engineered to Blockade Prostate Cancer Senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31553876 |mesh-terms=* Animals * Antineoplastic Agents * Apoptosis * Cell Line, Tumor * Cellular Senescence * Docetaxel * Forkhead Box Protein O1 * Humans * Male * Mice * Mice, Nude * Nanostructures * Polyphenols * Prostatic Neoplasms * Receptor, Transforming Growth Factor-beta Type I * Signal Transduction * Tannins * Transplantation, Heterologous |keywords=* DSAs * apoptosis * docetaxel * nanoassemblies * prostate cancer * senescence |full-text-url=https://sci-hub.do/10.1021/acsami.9b14738 }} {{medline-entry |title=An Immersive Virtual Reality Platform for Assessing Spatial Navigation Memory in Predementia Screening: Feasibility and Usability Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31482851 |keywords=* cognition * dementia * healthy aging * memory * virtual reality |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751096 }} ==PCNA== {{medline-entry |title=Impairment of Pol β-related DNA Base-excision Repair Leads to Ovarian Aging in Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33223510 |keywords=* BER * Pol β * menopause * oocytes * ovarian aging |full-text-url=https://sci-hub.do/10.18632/aging.104123 }} {{medline-entry |title=[Heat shock protein 90 (HSP90) in age-dependent changes in the number of fibroblasts in human skin.] |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32362082 |mesh-terms=* Adolescent * Adult * Aging * Child * Child, Preschool * Dermis * Female * Fibroblasts * HSP90 Heat-Shock Proteins * Humans * Infant * Infant, Newborn * Middle Aged * Pregnancy * Young Adult |keywords=* HSP90 * PCNA * aging * fibroblasts * skin }} {{medline-entry |title=A Higher Frequency Administration of the Nontoxic Cycloartane-Type Triterpene Argentatin A Improved Its Anti-Tumor Activity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32295227 |keywords=* Argentatin A * PCNA * antiproliferative * antitumor * apoptosis * cell senescence * colon cancer * xenografts |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221627 }} {{medline-entry |title=[Mechanosensitive protein of Hippo regulatory pathway - transcription coactivator with PZD-binding motif (TAZ) in human skin during aging.] |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32145162 |mesh-terms=* Adolescent * Adult * Aged * Aged, 80 and over * Aging * Child * Child, Preschool * Dermis * Female * Fibroblasts * Humans * Infant * Infant, Newborn * Middle Aged * Pregnancy * Protein-Serine-Threonine Kinases * Skin Aging * Trans-Activators * Young Adult |keywords=* CD31 * PCNA * TAZ * aging * blood vessels * fibroblasts * skin }} {{medline-entry |title=[Mechanosensitive Yes-associated protein in human skin during aging.] |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31800177 |mesh-terms=* Adaptor Proteins, Signal Transducing * Adult * Aged * Aged, 80 and over * Aging * Dermis * Endothelial Cells * Female * Fibroblasts * Humans * Middle Aged * Pregnancy * Skin Aging * Transcription Factors |keywords=* CD31 * PCNA * YAP * aging * blood vessels * fibroblasts * skin }} {{medline-entry |title=[Role of mechanosensitive protein Piezo1 in human age-dependent changes in the number of fibroblasts and blood vessels in human skin.] |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31512421 |mesh-terms=* Adolescent * Adult * Aged * Aged, 80 and over * Blood Vessels * Child * Child, Preschool * Dermis * Female * Fibroblasts * Humans * Infant * Ion Channels * Male * Middle Aged * Platelet Endothelial Cell Adhesion Molecule-1 * Pregnancy * Proliferating Cell Nuclear Antigen * Skin Aging |keywords=* CD31 * PCNA * Piezo1 * aging * blood vessels * fibroblasts * skin }} ==PCSK9== {{medline-entry |title=Lipoprotein removal mechanisms and aging: implications for the cardiovascular health of the elderly. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32011347 |mesh-terms=* Aged * Aged, 80 and over * Aging * Apolipoproteins B * Atherosclerosis * Cardiovascular Diseases * Cardiovascular System * Cholesterol * Humans * Lipid Metabolism * Lipoproteins * Lipoproteins, LDL * Risk Factors |full-text-url=https://sci-hub.do/10.1097/MED.0000000000000529 }} {{medline-entry |title=The role of proprotein convertase subtilisin-kexin type 9 ([[PCSK9]]) in the vascular aging process - is there a link? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31708986 |keywords=* PCSK9 * atherosclerosis * cholesterol * inflammation * vascular aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836637 }} ==PDCD4== {{medline-entry |title=Petal abscission in roses is associated with the activation of a truncated version of the animal [[PDCD4]] homologue, RbPCD1. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31521226 |mesh-terms=* Amino Acid Sequence * Arabidopsis * Gene Expression Regulation, Plant * Plant Proteins * Plants, Genetically Modified * Programmed Cell Death 1 Receptor * Rosa * Sequence Alignment * Transcription Factors |keywords=* Ethylene * Heat shock * Inflorescence * MA3 domain * PDCD4 * Repression * Senescence |full-text-url=https://sci-hub.do/10.1016/j.plantsci.2019.110242 }} ==PDE2A== {{medline-entry |title=TAK-915, a phosphodiesterase 2A inhibitor, ameliorates the cognitive impairment associated with aging in rodent models. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31521738 |mesh-terms=* Aging * Animals * Brain * Cognition * Cognition Disorders * Cognitive Dysfunction * Cyclic AMP * Cyclic GMP * Cyclic Nucleotide Phosphodiesterases, Type 2 * Male * Memory Disorders * Memory, Episodic * Phosphodiesterase Inhibitors * Pyrazines * Pyridines * Rats * Rats, Inbred F344 * Rats, Long-Evans * Rats, Sprague-Dawley |keywords=* Aging * Cognition * PDE2A * TAK-915 |full-text-url=https://sci-hub.do/10.1016/j.bbr.2019.112192 }} ==PDE4D== {{medline-entry |title=Phosphodiesterase [[PDE4D]] Is Decreased in Frontal Cortex of Aged Rats and Positively Correlated With Working Memory Performance and Inversely Correlated With PKA Phosphorylation of Tau. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33192469 |keywords=* Alzheimer’s disease * PDE4D * aging * tau * working memory |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655962 }} ==PDE5A== {{medline-entry |title=Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32513693 |mesh-terms=* Aging * Animals * Bone Density * Bone and Bones * Brain * Cell Differentiation * Cyclic Nucleotide Phosphodiesterases, Type 5 * Drug Repositioning * Erectile Dysfunction * Humans * Male * Mice * Middle Aged * Models, Animal * Models, Molecular * Neurons * Osteoblasts * Osteoclasts * Osteogenesis * Osteoporosis * Osteoporotic Fractures * Phosphodiesterase 5 Inhibitors * Primary Cell Culture * Tadalafil * Vardenafil Dihydrochloride |keywords=* PDE5 inhibitor * computational modeling * cyclic GMP * osteoporosis * resorption |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321982 }} ==PDK1== {{medline-entry |title=Inhibition of 3-phosphoinositide-dependent protein kinase 1 ([[PDK1]]) can revert cellular senescence in human dermal fibroblasts. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33229519 |keywords=* PDK1 * cellular senescence * network modeling * skin aging * systems biology |full-text-url=https://sci-hub.do/10.1073/pnas.1920338117 }} {{medline-entry |title=The Impact of the PI3K/Akt Signaling Pathway in Anxiety and Working Memory in Young and Middle-Aged [[PDK1]] K465E Knock-In Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32457586 |keywords=* PI3K/Akt * RDoC * aging * animal model * anxiety * cognition * fine tuning * signaling pathway |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225327 }} ==PER1== {{medline-entry |title=Quercetin, caffeic acid and resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31773385 |mesh-terms=* ARNTL Transcription Factors * Age Factors * Aging * CLOCK Proteins * Caffeic Acids * Cell Line * Circadian Clocks * Circadian Rhythm * Fibroblasts * Humans * NF-E2-Related Factor 2 * Polyphenols * Quercetin * Receptors, Glucocorticoid * Resveratrol * Sirtuin 1 |keywords=* Caffeic acid * Circadian clock genes * NR1D1 * NRF2 * Quercetin * Resveratrol |full-text-url=https://sci-hub.do/10.1007/s11033-019-05194-8 }} ==PER2== {{medline-entry |title=NAD Controls Circadian Reprogramming through [[PER2]] Nuclear Translocation to Counter Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32369735 |mesh-terms=* ARNTL Transcription Factors * Age Factors * Aging * Animals * CLOCK Proteins * Circadian Clocks * Circadian Rhythm * Cytokines * Female * HEK293 Cells * Humans * Male * Mice * Mice, Inbred C57BL * NAD * Period Circadian Proteins * Sirtuin 1 * Sirtuins |keywords=* NAD(+) * SIRT1 * aging * circadian * clock * heat shock factor 1 * liver * nicotinamide mononucleotide * nicotinamide riboside * transcriptomics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275919 }} ==PEX19== {{medline-entry |title=A genome-wide screen identifies genes that suppress the accumulation of spontaneous mutations in young and aged yeast cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31854076 |mesh-terms=* Amino Acid Transport Systems, Basic * Cellular Senescence * DNA Replication * Flap Endonucleases * Gene Ontology * Genetic Techniques * Genomic Instability * Membrane Proteins * Mutagenesis * Mutation * Mutation Accumulation * Mutation Rate * Nuclear Pore Complex Proteins * Saccharomyces cerevisiae * Saccharomyces cerevisiae Proteins * Single-Strand Specific DNA and RNA Endonucleases |keywords=* genome stability * high-throughput screen * mutagenesis * mutation rate * replicative aging * yeast |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996960 }} ==PEX5== {{medline-entry |title=Aging lowers [[PEX5]] levels in cortical neurons in male and female mouse brains. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32777345 |keywords=* Aging brain * PEX5 * Peroxisomal protein |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484460 }} ==PFAS== {{medline-entry |title=Associations between serum concentrations of perfluoroalkyl substances and DNA methylation in women exposed through drinking water: A pilot study in Ronneby, Sweden. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33007577 |keywords=* EPIC chip * Environmental pollutant * Epigenetic aging * Epigenetics * PFAS * Perfluoroalkyl substance |full-text-url=https://sci-hub.do/10.1016/j.envint.2020.106148 }} {{medline-entry |title=Perfluorinated alkyl substances impede growth, reproduction, lipid metabolism and lifespan in Daphnia magna. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32521362 |mesh-terms=* Alkanesulfonic Acids * Animals * Caprylates * Daphnia * Fatty Acids * Fluorocarbons * Humans * Lipid Metabolism * Longevity * Reproduction |keywords=* Fatty acid * Fecundity * Gene expression * PFAS toxicity * Perfluorooctane sulfonate (PFOS) * Perfluorooctanoic acid (PFOA) |full-text-url=https://sci-hub.do/10.1016/j.scitotenv.2020.139682 }} {{medline-entry |title=The effect of weathering on per- and polyfluoroalkyl substances ([[PFAS]]s) from durable water repellent (DWR) clothing. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32062207 |mesh-terms=* Acrylates * Alcohols * Clothing * Environmental Monitoring * Fluorocarbon Polymers * Fluorocarbons * Humidity * Models, Chemical * Textiles * Water * Water Pollutants, Chemical * Weather |keywords=* Aging * Durable water repellency * Outdoor clothing * Per- and polyfluoroalkyl substances * Textile * Weathering |full-text-url=https://sci-hub.do/10.1016/j.chemosphere.2020.126100 }} ==PGC== {{medline-entry |title=The Aging Stress Response and Its Implication for AMD Pathogenesis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33266495 |keywords=* AMD * DNA damage response * PGC-1α * SIRT1 * age-related macular degeneration * aging * autophagy * insulin/IGF-1 * mitochondrial quality control * the aging stress response |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7700335 }} {{medline-entry |title=Constitutive [[PGC]]-1α Overexpression in Skeletal Muscle Does Not Contribute to Exercise-Induced Neurogenesis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33200398 |keywords=* Aging * Hippocampal neurogenesis * Immunohistochemistry * PGC-1α * Transgenic mice * Voluntary running |full-text-url=https://sci-hub.do/10.1007/s12035-020-02189-6 }} {{medline-entry |title=Dysregulated Autophagy Mediates Sarcopenic Obesity and Its Complications via AMPK and [[PGC]]1α Signaling Pathways: Potential Involvement of Gut Dysbiosis as a Pathological Link. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32961822 |keywords=* AMPK signaling pathway * PGC-1α signaling pathway * aging * autophagy * gut axis * inflammation * insulin resistance * sarcopenic obesity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555990 }} {{medline-entry |title=Resemblance and differences in dietary restriction nephroprotective mechanisms in young and old rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32970613 |keywords=* aging * caloric restriction * ischemia/reperfusion * kidney injury * mitochondria |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585108 }} {{medline-entry |title=Acute and chronic effects of resistance training on skeletal muscle markers of mitochondrial remodeling in older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32748504 |keywords=* aging * mitochondrial dynamics * mitochondrial function |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399374 }} {{medline-entry |title=[[PGC]]-1α-mediated regulation of mitochondrial function and physiological implications. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32516539 |keywords=* aging * exercise metabolism * insulin resistance * mitochondrial metabolism * muscle metabolism * muscle physiology * métabolisme mitochondrial * métabolisme musculaire * métabolisme à l’effort * physiologie musculaire * résistance à l’insuline * vieillissement |full-text-url=https://sci-hub.do/10.1139/apnm-2020-0005 }} {{medline-entry |title=Targeting Mitochondrial Network Architecture in Down Syndrome and Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32365535 |keywords=* Down syndrome * PGC-1α/PPARGC1A * aging * mTOR * mitochondrial dynamics * mitochondrial function * mitochondrial network |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247689 }} {{medline-entry |title=Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age-specific manner. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32372536 |keywords=* ADP sensitivity * ROS * aging * autophagy |full-text-url=https://sci-hub.do/10.1096/fj.201903113RR }} {{medline-entry |title=A novel dipeptide from potato protein hydrolysate augments the effects of exercise training against high-fat diet-induced damages in senescence-accelerated mouse-prone 8 by boosting pAMPK / SIRT1/ [[PGC]]-1α/ pFOXO3 pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32335547 |keywords=* alcalase * bioactive peptides * cardio-protection * hepato-protection * longevity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202530 }} {{medline-entry |title=Mitochondrial nucleoid remodeling and biogenesis are regulated by the p53-p21 -PKCζ pathway in p16 -silenced cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32330121 |keywords=* mitochondria * nucleoid remodeling * p16INK4a silence * p53-p21-PKCζ activation * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202532 }} {{medline-entry |title=[Metabolic Alteration in Aging Process: Metabolic Remodeling in White Adipose Tissue by Caloric Restriction]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32115557 |mesh-terms=* Adipose Tissue, White * Aging * Animals * Caloric Restriction * Gene Expression * Humans * Longevity * Mice * Organelle Biogenesis * Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha * Sirtuin 3 * Sterol Regulatory Element Binding Protein 1 * Up-Regulation |keywords=* caloric restriction (CR) * fatty acid biosynthesis * mitochondria * white adipose tissue (WAT) |full-text-url=https://sci-hub.do/10.1248/yakushi.19-00193-2 }} {{medline-entry |title=Kynurenine aminotransferase isoforms display fiber-type specific expression in young and old human skeletal muscle. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32068089 |keywords=* Aging * Kynurenine aminotransferases * Mitochondria * Muscle fiber-type * Skeletal muscle |full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110880 }} {{medline-entry |title=Ubiquinol-10 delays postovulatory oocyte aging by improving mitochondrial renewal in pigs. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31958774 |keywords=* mitochondria * oxidative stress * pig * postovulatory aging * ubiquinol-10 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053629 }} {{medline-entry |title=Mitochondrial oxidative capacity and NAD biosynthesis are reduced in human sarcopenia across ethnicities. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31862890 |mesh-terms=* Aged * Aged, 80 and over * Aging * Biopsy * Case-Control Studies * Energy Metabolism * Humans * Jamaica * Male * Middle Aged * Mitochondria * Muscle, Skeletal * NAD * Oxidation-Reduction * Oxidative Phosphorylation * Oxidative Stress * Proteostasis * Sarcopenia * Singapore * United Kingdom |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925228 }} {{medline-entry |title=MicroRNA-34a (miR-34a) Mediates Retinal Endothelial Cell Premature Senescence through Mitochondrial Dysfunction and Loss of Antioxidant Activities. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31443378 |keywords=* diabetic retinopathy * miR-34a * mitochondrial dysfunction * vascular senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769710 }} {{medline-entry |title=Constitutive [[PGC]]-1α overexpression in skeletal muscle does not protect from age-dependent decline in neurogenesis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31444397 |mesh-terms=* Aging * Animals * Blood Proteins * Cytokines * Female * Hippocampus * Male * Mice, Inbred C57BL * Mice, Transgenic * Muscle, Skeletal * Neurogenesis * Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha * Reproducibility of Results |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707251 }} ==PGK2== {{medline-entry |title=Arsenic influences spermatogenesis by disorganizing the elongation of spermatids in adult male mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31472347 |mesh-terms=* Aging * Animals * Arsenic * Cell Cycle Proteins * DEAD-box RNA Helicases * Gene Expression Profiling * Male * Mice * RNA, Messenger * Spermatids * Spermatogenesis * Spermatozoa |keywords=* Arsenic * Elongation of spermatids * Male reproduction * Spermatogenesis |full-text-url=https://sci-hub.do/10.1016/j.chemosphere.2019.124650 }} ==PGLS== {{medline-entry |title=547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31779658 |mesh-terms=* Aging * Animals * Brain * Carboxylic Ester Hydrolases * Macaca mulatta * Male * Mice * Transcriptome |keywords=* Brain aging * Multiple brain regions * PGLS * Rhesus macaques * Transcriptome |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883628 }} ==PIEZO1== {{medline-entry |title=Niche stiffness underlies the ageing of central nervous system progenitor cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31413369 |mesh-terms=* Adult Stem Cells * Aging * Animals * Animals, Newborn * Cell Count * Central Nervous System * Extracellular Matrix * Female * Humans * Membrane Proteins * Multipotent Stem Cells * Oligodendroglia * Rats * Stem Cell Niche |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025879 }} ==PINK1== {{medline-entry |title=Spermidine inhibits neurodegeneration and delays aging via the [[PINK1]]-PDR1-dependent mitophagy pathway in [i]C. elegans[/i]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32902411 |keywords=* aging * caenorhabditis elegans * mitophagy * neurodegenerative diseases * spermidine |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521492 }} {{medline-entry |title=Female mice are resilient to age-related decline of substantia nigra dopamine neuron firing parameters. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32846275 |keywords=* Aging * Dopamine * Electrophysiology * Firing * Mouse * Substantia nigra |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606778 }} {{medline-entry |title=Attenuation of epigenetic regulator SMARCA4 and ERK-ETS signaling suppresses aging-related dopaminergic degeneration. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32749068 |keywords=* Drosophila * MAPK-ERK-ETS signaling * Parkinson's disease * SMARCA4/Brahma * aging * neurodegeneration |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511865 }} {{medline-entry |title=SIRT1 alleviates high-magnitude compression-induced senescence in nucleus pulposus cells via [[PINK1]]-dependent mitophagy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32687063 |keywords=* SIRT1 * compression * mitophagy * nucleus pulposus * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485741 }} {{medline-entry |title=Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32386191 |keywords=* Drosophila melanogaster * Levodopa induced dyskinesia * PINK1B9 * Parkinsonism * Parkinson’s disease * aging * antioxidant activity * catalase * climbing index * lifespan * oxidative stress * propolis |full-text-url=https://sci-hub.do/10.1515/jcim-2019-0136 }} {{medline-entry |title=Compression-induced senescence of nucleus pulposus cells by promoting mitophagy activation via the [[PINK1]]/PARKIN pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32281308 |keywords=* PARKIN pathway * PINK1 * compression * intervertebral disc * mitophagy * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214186 }} {{medline-entry |title=Doxorubicin-induced normal breast epithelial cellular aging and its related breast cancer growth through mitochondrial autophagy and oxidative stress mitigated by ginsenoside Rh2. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32100342 |mesh-terms=* Autophagy * Breast Neoplasms * Cell Culture Techniques * Cell Line, Tumor * Doxorubicin * Drugs, Chinese Herbal * Female * Ginsenosides * Humans * Mitochondria * Oxidative Stress |keywords=* ROS * cancer growth * cellular senescence * chemotherapy * ginsenoside Rh2 * mitophagy |full-text-url=https://sci-hub.do/10.1002/ptr.6636 }} {{medline-entry |title=Mitochondrial DNA heteroplasmy rises in substantial nigra of aged [[PINK1]] KO mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31727366 |mesh-terms=* Aging * Animals * Brain * DNA Copy Number Variations * DNA, Mitochondrial * Gene Frequency * Mice, Knockout * Mutation Rate * Protein Kinases * Substantia Nigra |keywords=* PINK1 * Parkin * Parkinson’s disease * mtDNA heteroplasmy |full-text-url=https://sci-hub.do/10.1016/j.bbrc.2019.10.112 }} ==PIP== {{medline-entry |title=Potentially inappropriate prescriptions according to explicit and implicit criteria in patients with multimorbidity and polypharmacy. MULTIPAP: A cross-sectional study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32785232 |mesh-terms=* Aged * Cross-Sectional Studies * Female * Geriatrics * Humans * Inappropriate Prescribing * Independent Living * Male * Multimorbidity * Polypharmacy * Potentially Inappropriate Medication List * Prevalence * Primary Health Care * Risk * Spain |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7423095 }} {{medline-entry |title=Quality of prescribing predicts hospitalisation in octogenarians: life and living in advanced age: a cohort study in New Zealand (LiLACS NZ). |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31856733 |mesh-terms=* Aged * Aged, 80 and over * Aging * Cohort Studies * Drug Prescriptions * Female * Follow-Up Studies * Forecasting * Hospitalization * Humans * Inappropriate Prescribing * Longitudinal Studies * Male * New Zealand * Patient Discharge * Potentially Inappropriate Medication List |keywords=* Appropriate prescribing * Ethnicity * Longitudinal study * Older people |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921419 }} ==PLIN2== {{medline-entry |title=Cardiac overexpression of perilipin 2 induces atrial steatosis, connexin 43 remodeling, and atrial fibrillation in aged mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31661297 |mesh-terms=* Animals * Atrial Fibrillation * Connexin 43 * Gene Knock-In Techniques * Heart Atria * Isolated Heart Preparation * Lipid Droplets * Mice * Mice, Transgenic * Microscopy, Electron * Myocytes, Cardiac * Perilipin-2 * Sterol Esterase * Triglycerides * Voltage-Sensitive Dye Imaging |keywords=* aging * cardiac steatosis * gap junction * lipid droplets * lipotoxic arrhythmia |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957375 }} ==PLK4== {{medline-entry |title=A novel lncRNA [[PLK4]] up-regulated by talazoparib represses hepatocellular carcinoma progression by promoting YAP-mediated cell senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32243714 |keywords=* Yes-associated protein * cellular senescence * hepatocellular carcinoma * polo-like kinase 4 associated lncRNA * talazoparib |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205816 }} {{medline-entry |title=Differential expression of AURKA/[[PLK4]] in quiescence and senescence of osteosarcoma U2OS cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32200684 |keywords=* AURKA * Osteosarcoma * PLK4 * quiescence * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217361 }} ==PLN== {{medline-entry |title=An analysis of the costs of treating aged patients in a large clinical hospital in Poland under the pressure of recent demographic trends. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32399116 |keywords=* Polish health care system * ageing society * gerontology * healthcare * hospital costs * length and cost of hospitalization |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212232 }} ==PML== {{medline-entry |title=Progressive multifocal leukoencephalopathy in dimethyl fumarate-treated multiple sclerosis patients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32808554 |keywords=* Multiple sclerosis * PML * fumarate * immunosenescence * lymphopenia |full-text-url=https://sci-hub.do/10.1177/1352458520949158 }} {{medline-entry |title=[[PML]]2-mediated thread-like nuclear bodies mark late senescence in Hutchinson-Gilford progeria syndrome. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32351002 |keywords=* HGPS * PML2 * senescence * thread-like PML NBs |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294779 }} ==PNN== {{medline-entry |title=Hyaluronan degradation and release of a hyaluronan-aggrecan complex from perineuronal nets in the aged mouse brain. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33253804 |keywords=* Brain aging * Chondroitin sulfate proteoglycan * Extracellular matrix * Hyaluronan * Perineuronal net |full-text-url=https://sci-hub.do/10.1016/j.bbagen.2020.129804 }} ==PNP== {{medline-entry |title=Temporal Discrimination Thresholds and Proprioceptive Performance: Impact of Age and Nerve Conduction. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31803012 |keywords=* TDMT * aging * kinesthesia * pointing task * position estimation * somatosensory temporal discrimination * temporal discrimination threshold |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877661 }} ==POLL== {{medline-entry |title=Temporal trends in loss of life expectancy after a cancer diagnosis among the Australian population. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32062407 |mesh-terms=* Aged * Aged, 80 and over * Australia * Cancer Survivors * Cohort Studies * Female * Humans * Life Expectancy * Male * Middle Aged * Neoplasms |keywords=* Australia * Cancer * Life expectancy * Survival * Temporal |full-text-url=https://sci-hub.do/10.1016/j.canep.2020.101686 }} ==POLR3A== {{medline-entry |title=Nucleolar disruption, activation of P53 and premature senescence in [[POLR3A]]-mutated Wiedemann-Rautenstrauch syndrome fibroblasts. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32976914 |keywords=* Cell senescence * DNA damage * Nucleolus * Nucleus * RNA polymerase III subunit A (POLR3A) * Wiedemann-Rautenstrauch syndrome |full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111360 }} ==POMC== {{medline-entry |title=Gpr17 deficiency in [[POMC]] neurons ameliorates the metabolic derangements caused by long-term high-fat diet feeding. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31611548 |mesh-terms=* Aging * Animals * Body Weight * Brain * Diet, High-Fat * Energy Metabolism * Female * Homeostasis * Insulin Resistance * Liver * Male * Mice * Mice, Knockout * Motor Activity * Nerve Tissue Proteins * Neurons * Pro-Opiomelanocortin * Receptors, G-Protein-Coupled * Sex Factors |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791877 }} ==POR== {{medline-entry |title=The Ventricular System Enlarges Abnormally in the Seventies, Earlier in Men, and First in the Frontal Horn: A Study Based on More Than 3,000 Scans. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31749695 |keywords=* Evans’ index * aging * brain * enlargement * hydrocephalus * normal pressure * ventricular system |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848156 }} ==POT1== {{medline-entry |title=MiR-185 targets [[POT1]] to induce telomere dysfunction and cellular senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32687062 |keywords=* aging * cellular senescence * miR-185 * protection of telomere 1 * telomere dysfunction |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425516 }} {{medline-entry |title=Seryl tRNA synthetase cooperates with [[POT1]] to regulate telomere length and cellular senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31815007 |keywords=* Cancer genomics * Senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882858 }} ==POU5F1== {{medline-entry |title=Cell quality evaluation with gene expression analysis of spheroids (3D) and adherent (2D) adipose stem cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33148459 |keywords=* ALDH family * Adipose stem cells * Aging * Shelterin complex * Spheroid * Telomere length |full-text-url=https://sci-hub.do/10.1016/j.gene.2020.145269 }} ==PPID== {{medline-entry |title=Relationships of inflamm-aging with circulating nutrient levels, body composition, age, and pituitary pars intermedia dysfunction in a senior horse population. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32058159 |mesh-terms=* Aging * Animals * Body Composition * Cytokines * Female * Folic Acid * Horse Diseases * Horses * Inflammation * Male * Nutrients * Pituitary Diseases * Pituitary Gland, Intermediate |keywords=* Horse * Inflamm-aging * Muscle * Nutrition * Pituitary pars intermedia dysfunction * Senior |full-text-url=https://sci-hub.do/10.1016/j.vetimm.2020.110013 }} ==PRDM8== {{medline-entry |title=[[PRDM8]] reveals aberrant DNA methylation in aging syndromes and is relevant for hematopoietic and neuronal differentiation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32819411 |keywords=* Aging * Aplastic anemia * DNA methylation * Dyskeratosis congenita * Epigenetic clock * Hematopoietic differentiation * Neuronal differentiation * PRDM8 * Telomere * iPSC |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439574 }} ==PRDX1== {{medline-entry |title=Active vitamin D supplementation alleviates initiation and progression of nonalcoholic fatty liver disease by repressing the p53 pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31756344 |mesh-terms=* Animals * Apoptosis * Cellular Senescence * Diet, High-Fat * Dietary Supplements * Fas Ligand Protein * Hepatocytes * Metabolic Networks and Pathways * Mice, Knockout * Non-alcoholic Fatty Liver Disease * Oxidative Stress * Proteins * Steroid Hydroxylases * Tumor Suppressor Protein p53 * Vitamin D * fas Receptor |keywords=* Active vitamin D * Apoptosis * Nonalcoholic fatty liver disease * Oxidative stress * Senescence * p53 pathway |full-text-url=https://sci-hub.do/10.1016/j.lfs.2019.117086 }} ==PRDX3== {{medline-entry |title=Proteomic analyses reveal that ginsenoside Rg3([i]S[/i]) partially reverses cellular senescence in human dermal fibroblasts by inducing peroxiredoxin. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32148389 |keywords=* Ginsenoside Rg3(S) * Human dermal fibroblast * Label-free quantitative proteomics * Restoration * Senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033328 }} ==PRDX6== {{medline-entry |title=Dentate Gyrus Peroxiredoxin 6 Levels Discriminate Aged Unimpaired From Impaired Rats in a Spatial Memory Task. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31417400 |keywords=* PRDX6 * aging * dentate gyrus * hippocampus * hole-board * peroxiredoxin * proteomics * spatial memory |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684764 }} ==PRKDC== {{medline-entry |title=DNA-PKcs modulates progenitor cell proliferation and fibroblast senescence in idiopathic pulmonary fibrosis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31464599 |mesh-terms=* Animals * Cell Line * Cell Proliferation * Cellular Senescence * Chromones * DNA Damage * DNA Repair * DNA-Activated Protein Kinase * DNA-Binding Proteins * Female * Fibroblasts * Humans * Idiopathic Pulmonary Fibrosis * Lung * Mesenchymal Stem Cells * Mice * Mice, SCID * Morpholines |keywords=* DNA-PKcs * IPF * Mesenchymal progenitor cells * Senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716822 }} ==PRL== {{medline-entry |title=Mechanism of [[PRL]]2 phosphatase-mediated PTEN degradation and tumorigenesis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32788364 |mesh-terms=* Animals * Carcinogenesis * Female * HEK293 Cells * Humans * Immediate-Early Proteins * Longevity * Male * Mice, Inbred C57BL * Mice, Knockout * Nedd4 Ubiquitin Protein Ligases * PTEN Phosphohydrolase * Protein Tyrosine Phosphatases * Proto-Oncogene Proteins c-akt * Ubiquitination |keywords=* NEDD4 * PRL2 * PTEN * protein tyrosine phosphatases * ubiquitination |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456095 }} {{medline-entry |title=Prolactin mitigates deficiencies of retinal function associated with aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31698287 |mesh-terms=* Aging * Animals * Apoptosis * Electroretinography * Mice, Inbred C57BL * Nerve Growth Factors * Neuroglia * Prolactin * Retina * Retinal Degeneration |keywords=* Aging * Apoptosis * Glia activation * Hormone * Mesotopic and photopic electroretinogram * Retina |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2019.10.002 }} {{medline-entry |title=A Spontaneous Aggressive ERα+ Mammary Tumor Model Is Driven by Kras Activation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31390566 |mesh-terms=* Aging * Animals * Carcinogenesis * Datasets as Topic * Estrogen Receptor alpha * Female * Gene Expression Profiling * Humans * Mammary Neoplasms, Experimental * Mice * Prolactin * Proto-Oncogene Proteins p21(ras) * Rats * Signal Transduction * Transgenes |keywords=* ER+ breast cancer * Ras mutations * breast cancer * genomic analyses * mouse models * prolactin |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713291 }} ==PRNP== {{medline-entry |title=Spontaneous generation of prions and transmissible PrP amyloid in a humanised transgenic mouse model of A117V GSS. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32516343 |mesh-terms=* Adult * Aging * Amyloid * Animals * Brain * Codon * Heterozygote * Homozygote * Humans * Mice, Transgenic * Middle Aged * Prions |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282622 }} ==PROC== {{medline-entry |title=Does midlife aging impact women's sleep duration, continuity, and timing?: A longitudinal analysis from the Study of Women's Health Across the Nation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31633180 |keywords=* actigraphy * aging * sleep duration * sleep in women * sleep quality |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157190 }} ==PSD== {{medline-entry |title=Quantitative Immunoblotting Analyses Reveal that the Abundance of Actin, Tubulin, Synaptophysin and EEA1 Proteins is Altered in the Brains of Aged Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32652177 |keywords=* aging * brain * cortex * glutamate receptor * synapse * vesicle |full-text-url=https://sci-hub.do/10.1016/j.neuroscience.2020.06.044 }} {{medline-entry |title=Exercise Attenuates Brain Aging by Rescuing Down-Regulated Wnt/β-Catenin Signaling in Aged Rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32390823 |keywords=* DKK-1 * Wnt * brain aging * exercise * β-catenin |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192222 }} {{medline-entry |title=Concurrent nicotine exposure to prenatal alcohol consumption alters the hippocampal and cortical neurotoxicity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31938742 |keywords=* Aging * Mitochondrial function * Neuroscience * Oxidative stress |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953639 }} ==PSEN2== {{medline-entry |title=Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human [[PSEN2]]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31978074 |mesh-terms=* Aging * Alternative Splicing * Alzheimer Disease * Animals * Animals, Genetically Modified * Brain * Datasets as Topic * Disease Models, Animal * Down-Regulation * Female * Frameshift Mutation * Gene Editing * Gene Regulatory Networks * Heterozygote * Humans * Microglia * Presenilin-1 * Presenilin-2 * Protein Isoforms * Proteomics * RNA-Seq * Up-Regulation * Zebrafish * Zebrafish Proteins |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980398 }} {{medline-entry |title=Loss of presenilin 2 age-dependently alters susceptibility to acute seizures and kindling acquisition. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31862541 |keywords=* Aging * Alzheimer's * Carbamazepine * Corneal kindling * Diazepam * Epilepsy * Lamotrigine * Levetiracetam * Presenilin * Seizures * Valproic acid |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7462087 }} ==PSMD11== {{medline-entry |title=The effect and mechanism of 19S proteasome [[PSMD11]]/Rpn6 subunit in D-Galactose induced mimetic aging models. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32450067 |keywords=* Age-related hearing loss * Aging * D-galactose * PSMD11 * Proteasome |full-text-url=https://sci-hub.do/10.1016/j.yexcr.2020.112093 }} ==PSMD14== {{medline-entry |title=Upregulation of deubiquitinase [[PSMD14]] in lung adenocarcinoma (LUAD) and its prognostic significance. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32226511 |keywords=* PMSD14 * apoptosis * deubiquitinating enzyme * lung adenocarcinoma * prognosis * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086243 }} ==PTEN== {{medline-entry |title=Senescence Reprogramming by TIMP1 Deficiency Promotes Prostate Cancer Metastasis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33186519 |keywords=* FGF1 * GDF-15 * MMPs * PTEN * TIMP1 * docetaxel * prostate cancer metastasis * senescence * senescence-associated secretory phenotype (SASP) * senolytic therapy |full-text-url=https://sci-hub.do/10.1016/j.ccell.2020.10.012 }} {{medline-entry |title=Alterations in Mitochondrial Dynamic-related Genes in the Peripheral Blood of Alzheimer's Disease Patients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33023448 |keywords=* Alzheimer's disease * DRP1 * FIS1 * aging * mitochondrial dynamics * mitophagy |full-text-url=https://sci-hub.do/10.2174/1567205017666201006162538 }} {{medline-entry |title=Human ESC-sEVs alleviate age-related bone loss by rejuvenating senescent bone marrow-derived mesenchymal stem cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32944188 |keywords=* Extracellular vesicle * bone loss * bone marrow MSCs * cellular senescence * embryonic stem cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480439 }} {{medline-entry |title=The precursor of PI(3,4,5)P alleviates aging by activating daf-18(Pten) and independent of daf-16. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32901024 |mesh-terms=* Aging * Animals * Animals, Genetically Modified * Caenorhabditis elegans * Caenorhabditis elegans Proteins * Cell Line, Tumor * Female * Forkhead Transcription Factors * Inositol * Locomotion * Longevity * Metabolic Networks and Pathways * Metabolomics * Mice * Mitophagy * Models, Animal * PTEN Phosphohydrolase * Phosphatidylinositol Phosphates * Protein Kinases * Protein-Serine-Threonine Kinases * RNA Interference * RNA-Seq |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479145 }} {{medline-entry |title=Quercetin alleviates kidney fibrosis by reducing renal tubular epithelial cell senescence through the SIRT1/PINK1/mitophagy axis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32702447 |mesh-terms=* Animals * Antioxidants * Cell Line * Cellular Senescence * Epithelium * Fibrosis * Flow Cytometry * Kidney * Kidney Tubules, Proximal * Mitophagy * Protein Kinases * Quercetin * Rats * Sirtuin 1 |keywords=* Fibrosis * Mitochondria * Mitophagy * Quercetin * Senescence |full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118116 }} {{medline-entry |title=Downregulation of [[PTEN]] mediates bleomycin-induced premature senescence in lung cancer cells by suppressing autophagy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32436415 |keywords=* PI3K/Akt/mTOR pathway * PTEN * autophagy * bleomycin * cancer cell * premature senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287201 }} {{medline-entry |title=miR-155 inhibits mitophagy through suppression of BAG5, a partner protein of PINK1. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31948758 |mesh-terms=* Adaptor Proteins, Signal Transducing * Aging * Animals * Cell Line * Cells, Cultured * Down-Regulation * Humans * Male * Mesenchymal Stem Cells * Mice, Inbred C57BL * MicroRNAs * Mitophagy * Protein Interaction Maps * Protein Kinases * Up-Regulation |keywords=* Aging * Bone marrow MSCs * Mitophagy * miR-155 |full-text-url=https://sci-hub.do/10.1016/j.bbrc.2020.01.022 }} {{medline-entry |title=Environmental Exposures and Asthma Development: Autophagy, Mitophagy, and Cellular Senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31849968 |mesh-terms=* Airway Remodeling * Asthma * Autophagy * Cellular Senescence * Disease Susceptibility * Environmental Exposure * Humans * Mitophagy * Oxidative Stress * Respiratory Mucosa |keywords=* asthma * autophagy * mitophagy * oxidative stress * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896909 }} {{medline-entry |title=[[PTEN]] loss regulates alveolar epithelial cell senescence in pulmonary fibrosis depending on Akt activation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31527305 |mesh-terms=* Aging * Cellular Senescence * Epithelial Cells * Humans * Idiopathic Pulmonary Fibrosis * PTEN Phosphohydrolase * Proto-Oncogene Proteins c-akt * Pulmonary Alveoli * Respiratory Mucosa |keywords=* aging * cellular senescence * phosphatase and tension homolog deleted on chromosome ten * protein kinase B * pulmonary fibrosis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781970 }} ==PTH== {{medline-entry |title=Vitamin D Receptor Polymorphisms in Sex-Frailty Paradox. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32899460 |keywords=* aging * frailty * vitamin D * vitamin D receptor |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551757 }} {{medline-entry |title=Parathyroid hormone ameliorates temporomandibular joint osteoarthritic-like changes related to age. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32154622 |mesh-terms=* Aging * Animals * Calcium-Regulating Hormones and Agents * Cells, Cultured * Disease Models, Animal * Male * Mice * Mice, Inbred C57BL * Osteoarthritis * Osteogenesis * Parathyroid Hormone * Temporomandibular Joint |keywords=* cellular senescence * cyclin-dependent kinase inhibitor P16INK4A * marrow mesenchymal stem cells * osteoarthritis * temporomandibular joint disorders |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162802 }} ==PTP4A3== {{medline-entry |title=Transcriptional and Functional Changes of the Human Microvasculature during Physiological Aging and Alzheimer Disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32402127 |keywords=* 3D microvascular network * blood-brain barrier * endothelium * human serum * vascular aging |full-text-url=https://sci-hub.do/10.1002/adbi.202000044 }} ==PTPN11== {{medline-entry |title=Fine mapping genetic variants associated with age at puberty and sow fertility using SowPro90 genotyping array. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32888012 |keywords=* SowPro90 * Bayes interval mapping * custom genotyping array * gilts * puberty * reproductive longevity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7568434 }} ==PTTG1== {{medline-entry |title=[Down-regulated [[PTTG1]] expression promotes the senescence of human prostate cancer LNCaP-AI]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32216239 |mesh-terms=* Cell Line, Tumor * Cell Proliferation * Humans * Male * Prostatic Neoplasms, Castration-Resistant * RNA, Small Interfering * Securin * beta-Galactosidase |keywords=* LNCaP-AI cell * castration-resistant prostate cancer * cellular senescence * pituitary tumor-transforming gene-1 * prostate cancer }} ==PTX3== {{medline-entry |title=Aerobic Training Down-Regulates Pentraxin 3 and Pentraxin 3/Toll-Like Receptor 4 Ratio, Irrespective of Oxidative Stress Response, in Elderly Subjects. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32012711 |keywords=* aging * endurance training * exercise * inflammation * oxidative stress * pentraxin 3 * toll-like receptor 4 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070734 }} {{medline-entry |title=Sex Differences in the Association Between Pentraxin 3 and Cognitive Decline: The Cardiovascular Health Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31808814 |keywords=* Biomarkers * Cognitive aging * Inflammation * Sex differences |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357589 }} ==PUM1== {{medline-entry |title=Identification of reference genes for RT-qPCR data normalisation in aging studies. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31562345 |mesh-terms=* Aging * Algorithms * Gene Expression Profiling * Genes, Essential * Humans * Real-Time Polymerase Chain Reaction * Software |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764958 }} ==RACK1== {{medline-entry |title=Invariable stoichiometry of ribosomal proteins in mouse brain tissues with aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31636180 |mesh-terms=* Aging * Animals * Brain * Female * Gene Expression Regulation, Developmental * Male * Mice * Proteomics * Ribosomal Proteins |keywords=* aging * mass spectrometry * neuronal tissues * ribosome * translation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842600 }} ==RAF1== {{medline-entry |title=Circular [i]ANRIL[/i] isoforms switch from repressors to activators of [i]p15/CDKN2B[/i] expression during [[RAF1]] oncogene-induced senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32862732 |keywords=* INK4 locus * Non-coding RNAs * Polycomb proteins * circular RNAs * gene expression regulation * oncogene-induced senescence |full-text-url=https://sci-hub.do/10.1080/15476286.2020.1812910 }} ==RAG1== {{medline-entry |title=T cell senescence accelerates Angiotensin II-induced target organ damage. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32049355 |keywords=* T cell * angiotensin II * cardiorenal dysfunction * senescence |full-text-url=https://sci-hub.do/10.1093/cvr/cvaa032 }} ==RAG2== {{medline-entry |title=Phosphate Transporter Profiles in Murine and Human Thymi Identify Thymocytes at Distinct Stages of Differentiation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32793218 |keywords=* aging * glucose transporters * human * metabolism * mice * phosphate transporters * thymus |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387685 }} ==RAN== {{medline-entry |title=Rapid automatized naming ([[RAN]]): effects of aging on a predictor of reading skill. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32799742 |keywords=* Aging * RAN * individual differences * naming * reading |full-text-url=https://sci-hub.do/10.1080/13825585.2020.1806987 }} ==RELB== {{medline-entry |title=New control of the senescence barrier in breast cancer. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32158912 |keywords=* CEBPB * Cellular senescence * PAK4 * RELB * p21-activated kinase |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051141 }} ==REST== {{medline-entry |title=[Brain and Neuronal Aging: Aged Brain Controls via Gene Expression Fidelity and Master Regulatory Factors]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32115559 |mesh-terms=* Aged * Aged, 80 and over * Aging * Animals * Brain * Gene Expression * Gene Expression Regulation, Developmental * Humans * Neurodegenerative Diseases * Protein Biosynthesis * Repressor Proteins * Ribosomes |keywords=* aging * brain * gene expression * neurodegeneration * ribosome * translational fidelity |full-text-url=https://sci-hub.do/10.1248/yakushi.19-00193-4 }} {{medline-entry |title=Effect of 9 - PAHSA on cognitive dysfunction in diabetic mice and its possible mechanism. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32014256 |mesh-terms=* Aging * Animals * Behavior, Animal * Blood Glucose * Body Weight * Brain * Brain-Derived Neurotrophic Factor * Cognitive Dysfunction * Diabetes Mellitus, Experimental * Exploratory Behavior * Male * Memory Disorders * Mice * Palmitic Acid * Repressor Proteins * Social Behavior * Spatial Memory * Stearic Acids |keywords=* 9-PAHSA * BDNF * Diabetes mellitus * REST |full-text-url=https://sci-hub.do/10.1016/j.bbrc.2020.01.071 }} {{medline-entry |title=Increased [[REST]] to Optimize Life Span? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31762373 |mesh-terms=* Animals * Caenorhabditis elegans * Caenorhabditis elegans Proteins * Homeostasis * Longevity * Repressor Proteins * Signal Transduction |keywords=* life span * neuronal activity * neurotoxicity |full-text-url=https://sci-hub.do/10.1089/rej.2019.2287 }} ==RET== {{medline-entry |title=Effects of resistance exercise training on redox homeostasis in older adults. A systematic review and meta-analysis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32615210 |keywords=* Aging * Antioxidants * Exercise * Oxidative stress * Resistance exercise training |full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111012 }} {{medline-entry |title=Effects of an 8-week resistance training intervention on plantar flexor muscle quality and functional capacity in older women: A randomised controlled trial. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32562747 |keywords=* Aging * Muscle echo intensity * Muscle quality * Physical function * Resistance training |full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111003 }} {{medline-entry |title=Resistance exercise training promotes fiber type-specific myonuclear adaptations in older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32134710 |keywords=* aging * hypertrophy * myonuclear domain * skeletal muscle |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191507 }} {{medline-entry |title=Low skeletal muscle capillarization limits muscle adaptation to resistance exercise training in older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31518665 |mesh-terms=* Adaptation, Physiological * Aged * Capillaries * Citrate (si)-Synthase * Exercise * Female * Humans * Hypertrophy * Male * Muscle Fibers, Skeletal * Muscle Proteins * Muscle, Skeletal * Resistance Training * Sarcopenia * Ubiquitin-Protein Ligases |keywords=* Aging * Capillary * Fiber cross-sectional area * Muscle hypertrophy * Muscle protein synthesis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904952 }} ==REV1== {{medline-entry |title=[[REV1]] inhibitor JH-RE-06 enhances tumor cell response to chemotherapy by triggering senescence hallmarks. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33168727 |keywords=* Rev1 * cell death * chemotherapy * senescence * translesion synthesis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682577 }} ==RHEB== {{medline-entry |title=The Rheb-TORC1 signaling axis functions as a developmental checkpoint. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32041790 |mesh-terms=* Animals * Animals, Genetically Modified * Autophagy * CRISPR-Cas Systems * Caenorhabditis elegans * Caenorhabditis elegans Proteins * Life Cycle Stages * Longevity * Mechanistic Target of Rapamycin Complex 1 * Phosphotransferases (Alcohol Group Acceptor) * RNA Interference * RNA, Small Interfering * Ras Homolog Enriched in Brain Protein * Signal Transduction |keywords=* MTOR * MTORC1 * Ral * RalGAP * TSC * Tuberous sclerosis complex |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063671 }} ==RHO== {{medline-entry |title=Conditional reprogramming: next generation cell culture. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32963937 |keywords=* 3T3-J2 fibroblast * AACR, American Association for Cancer Research * ACC, adenoid cystic carcinoma * AR, androgen receptor * CFTR, cystic fibrosis transmembrane conductance regulators * CR, conditional reprogramming * CYPs, cytochrome P450 enzymes * Conditional reprogramming * DCIS, ductal carcinoma in situ * ECM, extracellular matrix * ESC, embryonic stem cell * HCMI, human cancer model initiatives * HGF, hepatocyte growth factor * HNE, human nasal epithelial * HPV, human papillomaviruses * ICD, intracellular domain * LECs, limbal epithelial cells * NCI, National Cancer Institute * NGFR, nerve growth factor receptor * NSCLC, non-small cell lung cancer * NSG, NOD/SCID/gamma * PDAC, pancreatic ductal adenocarcinoma * PDX, patient derived xenograft * PP2A, protein phosphatase 2A * RB, retinoblastoma-associated protein * ROCK * ROCK, Rho kinase * SV40, simian virus 40 large tumor antigen * Senescence * UVB, ultraviolet radiation b * Y-27632 * dECM, decellularized extracellular matrix * hASC, human adipose stem cells * hTERT, human telomerase reverse transcriptase * iPSCs, induction of pluripotent stem cells * ΔNP63α, N-terminal truncated form of P63α |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488362 }} {{medline-entry |title=SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32246845 |mesh-terms=* Adult * Aging * Angiotensin-Converting Enzyme 2 * Bronchi * COVID-19 * Cells, Cultured * Chronic Disease * Coronavirus Infections * Epithelial Cells * Female * Gene Expression * Gene Expression Profiling * Germany * Goblet Cells * Humans * Lung * Male * Middle Aged * Pandemics * Peptidyl-Dipeptidase A * Pneumonia, Viral * Reference Standards * Sequence Analysis, RNA * Serine Endopeptidases * Sex Characteristics * Single-Cell Analysis * Smoking * Tissue Banks |keywords=* FURIN * COVID-19 * Human Cell Atlas * epithelial differentiation * respiratory tract |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232010 }} ==RICTOR== {{medline-entry |title=Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31476350 |mesh-terms=* Cellular Senescence * Endothelial Cells * Human Umbilical Vein Endothelial Cells * Humans * MicroRNAs * Nerve Tissue Proteins * Phosphorylation * Protein Binding * Rapamycin-Insensitive Companion of mTOR Protein * Ribonucleoproteins * Telomeric Repeat Binding Protein 2 * Ubiquitin-Protein Ligases |keywords=* Inflammation * MKRN1 * Senescence * Senescence-associated secretory phenotype (SASP) * Telomeric repeat binding factor 2-interacting protein (TERF2IP) * p90RSK |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059097 }} ==RIF1== {{medline-entry |title=53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31653568 |mesh-terms=* Aging * Animals * BRCA1 Protein * DNA Breaks, Double-Stranded * DNA Damage * Genomic Instability * Homologous Recombination * Mice * Mutation * Poly(ADP-ribose) Polymerase Inhibitors * Rad51 Recombinase * Tumor Suppressor p53-Binding Protein 1 * Ubiquitin-Protein Ligases |keywords=* 53BP1 * BRCA1 * PARPi * aging * cancer * homologous recombination * resection * shieldin |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6993210 }} ==RIPK1== {{medline-entry |title=Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33206046 |keywords=* aging * cell biology * mouse * necroptosis * protein kinase * reproductivity * testis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673785 }} {{medline-entry |title=Crucial role of the terminal complement complex in chondrocyte death and hypertrophy after cartilage trauma. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31981738 |keywords=* Aurintricarboxylic acid * Cartilage trauma * Hypertrophy * Regulated cell death * Senescence * Terminal complement complex |full-text-url=https://sci-hub.do/10.1016/j.joca.2020.01.004 }} ==RIPK3== {{medline-entry |title=Metformin mediates cardioprotection against aging-induced ischemic necroptosis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31944526 |mesh-terms=* Aging * Animals * Autophagy * GTPase-Activating Proteins * Humans * Hypoglycemic Agents * Imidazoles * Indoles * Male * Metformin * Mice * Mice, Inbred C57BL * Mice, Knockout * Myocardium * Myocytes, Cardiac * Necroptosis * Protein Binding * RNA, Small Interfering * Receptor-Interacting Protein Serine-Threonine Kinases * Reperfusion Injury * Sequestosome-1 Protein |keywords=* aging * autophagy defect * cardioprotection * ischemia/reperfusion injury * metformin * myocardial necroptosis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996959 }} ==RNF10== {{medline-entry |title=Reduced RING finger protein 10 expression in macrophages is associated with aging-related inflammation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33249776 |keywords=* E3 ubiquitin ligase * RNF10 * immunosenescence * inflammation * macrophages |full-text-url=https://sci-hub.do/10.1002/2211-5463.13049 }} ==RNF13== {{medline-entry |title=The effects of environmental stressors on candidate aging associated genes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32344118 |keywords=* Aging * Candidate genes * Environmental factors * Epigenetic * Hypo/hyper methylated (methylation) |full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110952 }} ==ROCK2== {{medline-entry |title=Physical exercise increases ROCK activity in the skeletal muscle of middle-aged rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32032622 |keywords=* Aging * Insulin resistance * Physical exercise * Rho-kinase (ROCK) |full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111213 }} ==RPE== {{medline-entry |title=Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33307245 |keywords=* Aging * Human embryonic stem cell * Human pluripotent stem cell * Retinal pigment epithelium * Single-cell RNA sequencing |full-text-url=https://sci-hub.do/10.1016/j.gpb.2020.08.002 }} {{medline-entry |title=Relationship between Oxygen Uptake, Heart Rate, and Perceived Effort in an Aquatic Incremental Test in Older Women. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33187067 |keywords=* aging * cardiorespiratory * maximum test * rate of perceived exertion * water aerobics * water-based exercises |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697777 }} {{medline-entry |title=Photoreceptor Degeneration in Homozygous Male Per2 Mice During Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33135952 |keywords=* Per2luc * aging * circadian * mice * photoreceptors * retinal pigment epithelium |full-text-url=https://sci-hub.do/10.1177/0748730420965285 }} {{medline-entry |title=An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into [[RPE]] Stress Associated with Retinopathy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32932802 |keywords=* AMD * RPE * aging * autofluorescence * autophagy * diet * lysosomes * oxidized POS * proteolysis * retina |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555953 }} {{medline-entry |title=Short-Term Effect of Self-Selected Training Intensity on Ambulatory Blood Pressure in Hypertensive Older Women: A Randomized Controlled Trial. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32904579 |keywords=* aging * exercise * hypertension |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457386 }} {{medline-entry |title=Correlation between brain volume and retinal photoreceptor outer segment volume in normal aging and neurodegenerative diseases. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32881874 |mesh-terms=* Aged * Aging * Brain * Female * Humans * Linear Models * Magnetic Resonance Imaging * Male * Middle Aged * Multivariate Analysis * Neurodegenerative Diseases * Organ Size * Retinal Photoreceptor Cell Outer Segment * Retinal Pigment Epithelium * Tomography, Optical Coherence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470418 }} {{medline-entry |title=Oxidative stress in the retina and retinal pigment epithelium ([[RPE]]): Role of aging, and DJ-1. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32826201 |keywords=* Aging * DJ-1 * Oxidative stress * Retina * Retinal pigment epithelium * Sodium iodate |full-text-url=https://sci-hub.do/10.1016/j.redox.2020.101623 }} {{medline-entry |title=Direct-Coupled Electroretinogram (DC-ERG) for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32744516 |mesh-terms=* Aging * Animals * Electrophysiological Phenomena * Electroretinography * Light * Mice * Retinal Pigment Epithelium |full-text-url=https://sci-hub.do/10.3791/61491 }} {{medline-entry |title=High-density lipoproteins are a potential therapeutic target for age-related macular degeneration. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32737203 |keywords=* age-related macular degeneration * aging * apolipoprotein * complement * complement factor H * glycosaminoglycan * heparan sulfate * heparan sulfate proteoglycans * high-density lipoprotein (HDL) * lipoprotein * oligosaccharide * retinal degeneration * retinal pigmented epithelium |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521644 }} {{medline-entry |title=MTOR-initiated metabolic switch and degeneration in the retinal pigment epithelium. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32721041 |keywords=* AMD * Mtor * aging * lipid * metabolism |full-text-url=https://sci-hub.do/10.1096/fj.202000612R }} {{medline-entry |title=[i]Lactobacillus paracasei[/i] KW3110 Suppresses Inflammatory Stress-Induced Premature Cellular Senescence of Human Retinal Pigment Epithelium Cells and Reduces Ocular Disorders in Healthy Humans. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32708511 |keywords=* cellular senescence * eye fatigue * inflammation * lactic acid bacteria * probiotics * retina |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403967 }} {{medline-entry |title=Retinal pigment epithelium transcriptome analysis in chronic smoking reveals a suppressed innate immune response and activation of differentiation pathways. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32634473 |keywords=* Age-related macular degeneration * Aging * Differentiation * Innate immunity * RNA sequencing * Smoking |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434665 }} {{medline-entry |title=Differences in Intraretinal Pigment Migration Across Inherited Retinal Dystrophies. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32442431 |mesh-terms=* Adult * Aging * Cell Movement * Female * Follow-Up Studies * Humans * Male * Ophthalmoscopy * Retinal Dystrophies * Retinal Pigment Epithelium * Retrospective Studies * Slit Lamp Microscopy * Tomography, Optical Coherence |full-text-url=https://sci-hub.do/10.1016/j.ajo.2020.05.010 }} {{medline-entry |title=Exosomal MiRNA Transfer between Retinal Microglia and [[RPE]]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32429541 |keywords=* RPE * aging * exosome * inflammation * microglia |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279010 }} {{medline-entry |title=Functionally validated imaging endpoints in the Alabama study on early age-related macular degeneration 2 (ALSTAR2): design and methods. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32429847 |keywords=* Age-related macular degeneration * Aging * Cones * Dark adaptation * Light sensitivity * Macula * Quantitative autofluorescence * Retina * Rods * Spectral domain optical coherence tomography |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236516 }} {{medline-entry |title=Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32298788 |keywords=* Age-related macular degeneration * Aggregation * Aging * Autophagy * Clearance * Degeneration * Mitochondria * Mitophagy * Retina * Retinal pigment epithelium |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650008 }} {{medline-entry |title=CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and [[RPE]] disorganization. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32234210 |keywords=* RPE disorganization * aging * choroid * choroidal macrophage * choroidal vasculature * immunology * inflammation * mouse * neuroscience |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156269 }} {{medline-entry |title=Extracellular microparticles exacerbate oxidative damage to retinal pigment epithelial cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32173468 |keywords=* Extracellular vesicles * Oxidative stress * Phagocytosis * RPE cell Dysfunction * RPE cell-Derived microparticles (RMPs) * Retinal pigment epithelial cell (RPE) * Senescence |full-text-url=https://sci-hub.do/10.1016/j.yexcr.2020.111957 }} {{medline-entry |title=Water-based continuous and interval training in older women: Cardiorespiratory and neuromuscular outcomes (WATER study). |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32145293 |keywords=* Aerobic capacity * Aerobic training * Aging * Aquatic exercise * Interval exercise * Muscle echo intensity * Muscle strength * Muscle thickness |full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110914 }} {{medline-entry |title=Retrieval Practice Improves Recollection-Based Memory Over a Seven-Day Period in Younger and Older Adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32038382 |keywords=* aging * recollection and familiarity * retrieval practice * temporal dynamics * testing effect |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990689 }} {{medline-entry |title=A Comparison of Heart Rate Training Load and Perceptual Effort Between Masters and Young Cyclists |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32000141 |mesh-terms=* Adult * Aging * Bicycling * Heart Rate * High-Intensity Interval Training * Humans * Middle Aged * Perception * Physical Exertion |keywords=* age * endurance training * high-intensity interval training * older athlete |full-text-url=https://sci-hub.do/10.1123/ijspp.2019-0413 }} {{medline-entry |title=Retinal Pigment Epithelial Cells: The Unveiled Component in the Etiology of Prpf Splicing Factor-Associated Retinitis Pigmentosa. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31884616 |mesh-terms=* Animals * Circadian Rhythm * Epithelial Cells * Eye Proteins * Humans * Mice * Phagocytosis * Photoreceptor Cells, Vertebrate * RNA Splicing Factors * Retinal Pigment Epithelium * Retinitis Pigmentosa |keywords=* Aging * Cellular stress * Circadian rhythm * Metabolism * PRPF * Phagocytosis * Retinal pigment epithelium * Retinitis pigmentosa * Splicing factors |full-text-url=https://sci-hub.do/10.1007/978-3-030-27378-1_37 }} {{medline-entry |title=AMPK May Play an Important Role in the Retinal Metabolic Ecosystem. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31884657 |mesh-terms=* AMP-Activated Protein Kinases * Animals * DNA Damage * DNA, Mitochondrial * Disease Models, Animal * Gene Dosage * Metformin * Mice * Oxidative Stress * Retina * Retinal Degeneration * Retinitis Pigmentosa |keywords=* AMPK * Adenosine monophosphate-activated protein kinase * Aging * Glycolysis * Metabolism * Neuroprotection * Retina |full-text-url=https://sci-hub.do/10.1007/978-3-030-27378-1_78 }} {{medline-entry |title=Stem cell-derived retinal pigment epithelium from patients with age-related macular degeneration exhibit reduced metabolism and matrix interactions. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31840941 |keywords=* Bruch's membrane * age-related macular degeneration * aging * induced pluripotent stem cells * nonenzymatic nitration * retinal pigment epithelium |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031648 }} {{medline-entry |title=Elovanoids counteract oligomeric β-amyloid-induced gene expression and protect photoreceptors. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31712409 |mesh-terms=* Amyloid beta-Peptides * Animals * Apoptosis * Autophagy * Cells, Cultured * Docosahexaenoic Acids * Extracellular Matrix * Fatty Acids, Omega-3 * Gene Expression Regulation * Humans * Male * Mice, Inbred C57BL * Mice, Transgenic * Photoreceptor Cells * Retina * Retinal Pigment Epithelium * Young Adult |keywords=* SASP * age-related macular degeneration * p16 * retinal pigment epithelial cells * senescence gene program |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883841 }} {{medline-entry |title=Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31699817 |mesh-terms=* Aging * Animals * Basement Membrane * Bruch Membrane * Exocytosis * Humans * Lysosomal-Associated Membrane Protein 2 * Lysosomes * Macular Degeneration * Mice * Mice, Knockout * Phagocytosis * Retina * Retinal Pigment Epithelium |keywords=* LAMP2 * aging * lysosome * retinal degeneration |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876195 }} {{medline-entry |title=Age, lipofuscin and melanin oxidation affect fundus near-infrared autofluorescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31648994 |mesh-terms=* Age Factors * Animals * Biomarkers * Choroid * Disease Models, Animal * Female * Fluorescein Angiography * Fundus Oculi * Humans * Lipofuscin * Macular Degeneration * Male * Melanins * Melanosomes * Mice * Mice, Knockout * Optical Imaging * Oxidation-Reduction * Oxidative Stress * Protein Transport * Retinal Pigment Epithelium * Tomography, Optical Coherence |keywords=* Aging * Lipofuscin * Melanin * Melanolipofuscin * Oxidative stress |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838394 }} {{medline-entry |title=Relevance of working memory for reinforcement learning in older adults varies with timescale of learning. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31544587 |keywords=* Aging * computational modeling * individual differences * reinforcement learning * working memory |full-text-url=https://sci-hub.do/10.1080/13825585.2019.1664389 }} {{medline-entry |title=Expression and Function of Mas-Related G Protein-Coupled Receptor D and Its Ligand Alamandine in Retina. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31392515 |mesh-terms=* Aging * Angiotensin II * Animals * Cells, Cultured * Electroretinography * Humans * Ligands * Lipopolysaccharides * Mice, Inbred C57BL * Mice, Knockout * Oligopeptides * Rats * Reactive Oxygen Species * Receptors, G-Protein-Coupled * Retina |keywords=* Alamandine * Angiotensin-(1–7) * Mas-related G protein-coupled receptor D * Rennin-angiotensin system * Retina |full-text-url=https://sci-hub.do/10.1007/s12035-019-01716-4 }} ==RPIA== {{medline-entry |title=Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31433975 |mesh-terms=* Aldose-Ketose Isomerases * Animals * Cell Line * Cellular Senescence * Cyclin-Dependent Kinase Inhibitor p16 * Gene Knockdown Techniques * Humans * Male * Mechanistic Target of Rapamycin Complex 1 * Mice, SCID * Nucleotides * Pentose Phosphate Pathway * Protein Biosynthesis |keywords=* BRAF * cancer metabolism * cell cycle * melanoma * nevi * pancreatic cancer * pentose phosphate pathway * ribonucleotide reductase M2 * ribose-5-phosphate isomerase A * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716532 }} ==RPS19BP1== {{medline-entry |title=Material basis, effect, and mechanism of ethanol extract of Pinellia ternata tubers on oxidative stress-induced cell senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32659678 |keywords=* Oxidative stress * Pinellia ternata * SIRT1 * Senescence |full-text-url=https://sci-hub.do/10.1016/j.phymed.2020.153275 }} ==RTEL1== {{medline-entry |title=Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31444995 |mesh-terms=* Adult * Aged * Aged, 80 and over * Aging * Cohort Studies * Female * Humans * Male * Mendelian Randomization Analysis * Middle Aged * Risk Factors * Telomere Homeostasis |keywords=* TERT * UK Biobank * anti-aging * cellular senescence * centenarians * frailty * longevity * sarcopenia |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826144 }} ==RXFP3== {{medline-entry |title=The [[RXFP3]] receptor is functionally associated with cellular responses to oxidative stress and DNA damage. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31794429 |mesh-terms=* Camptothecin * Computational Biology * DNA Damage * Felodipine * GTPase-Activating Proteins * Gene Expression Regulation * Gene Regulatory Networks * HEK293 Cells * Humans * Oxidative Stress * RNA, Messenger * Receptors, G-Protein-Coupled * Topoisomerase I Inhibitors |keywords=* DNA damage * GPCR * aging * relaxin 3 * relaxin family peptide 3 receptor |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932917 }} ==S100A4== {{medline-entry |title=Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31678243 |mesh-terms=* Alarmins * Animals * Cytokines * Exosomes * Lung * Mesenchymal Stem Cells * Mice * Mitochondria * Mitophagy * Oxidative Phosphorylation * Smoke * Tobacco |keywords=* COPD * Cellular Senescence * Exosomes * Mesenchymal stem cells * Mitochondria |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894395 }} ==S100A9== {{medline-entry |title=Cigarette smoke induction of [[S100A9]] contributes to chronic obstructive pulmonary disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32964723 |keywords=* Cigarette smoke * S100A9 * aging * kinase * pulmonary function |full-text-url=https://sci-hub.do/10.1152/ajplung.00207.2020 }} {{medline-entry |title=Modulation of KDM1A with vafidemstat rescues memory deficit and behavioral alterations. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32469975 |mesh-terms=* Aging * Alzheimer Disease * Animals * Behavior, Animal * Brain * Disease Models, Animal * Enzyme Inhibitors * Epigenesis, Genetic * Female * Gene Expression * Hippocampus * Histone Demethylases * Humans * Male * Memory Disorders * Mice * Mice, Inbred C57BL * Mice, Mutant Strains * Monoamine Oxidase Inhibitors * Oxadiazoles * Rats * Rats, Sprague-Dawley |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259601 }} {{medline-entry |title=Cellular senescence induced by [[S100A9]] in mesenchymal stromal cells through NLRP3 inflammasome activation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31727865 |mesh-terms=* Adolescent * Adult * Aged * Aged, 80 and over * Calgranulin B * Case-Control Studies * Cell Line * Cells, Cultured * Cellular Reprogramming * Cellular Senescence * Female * Humans * Inflammasomes * Interleukin-1beta * Male * Mesenchymal Stem Cells * Middle Aged * Myelodysplastic Syndromes * NLR Family, Pyrin Domain-Containing 3 Protein * Reactive Oxygen Species * Signal Transduction * Stem Cell Niche * Toll-Like Receptor 4 * Up-Regulation * Young Adult |keywords=* NLRP3 * S100A9 * cellular senescence * mesenchymal stromal cells * myelodysplastic syndromes |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874461 }} {{medline-entry |title=[[S100A9]] extends lifespan in insulin deficiency. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31391467 |mesh-terms=* Animals * Calgranulin B * Diabetes Mellitus, Experimental * Diphtheria Toxin * Fatty Acids * Humans * Hyperglycemia * Insulin * Leptin * Liver * Longevity * Male * Mice * Mice, Knockout * Oxidation-Reduction * Signal Transduction * Streptozocin * Toll-Like Receptor 4 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686003 }} ==S100B== {{medline-entry |title=Aging protects rat cortical slices against to oxygen-glucose deprivation induced damage. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32064981 |keywords=* Aging * LDH * S100B * edema * oxygen-glucose deprivation |full-text-url=https://sci-hub.do/10.1080/00207454.2020.1730830 }} ==S1PR1== {{medline-entry |title=Aging Suppresses Sphingosine-1-Phosphate Chaperone ApoM in Circulation Resulting in Maladaptive Organ Repair. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32544390 |keywords=* aging * endothelial cell * fibrosis * kidney repair * lipoprotein * lung regeneration * sphingosine-1-phosphate receptor * vascular barrier * vascular niche |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607448 }} ==SAG== {{medline-entry |title=WRKY42 transcription factor positively regulates leaf senescence through modulating SA and ROS synthesis in Arabidopsis thaliana. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32634860 |keywords=* WRKY42 * Arabidopsis * leaf senescence * reactive oxygen species * salicylic acid |full-text-url=https://sci-hub.do/10.1111/tpj.14914 }} {{medline-entry |title=Neurogenesis in the inner ear: the zebrafish statoacoustic ganglion provides new neurons from a Neurod/Nestin-positive progenitor pool well into adulthood. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32165493 |mesh-terms=* Adult Stem Cells * Aging * Animals * Animals, Genetically Modified * Basic Helix-Loop-Helix Transcription Factors * Cell Differentiation * Ear, Inner * Embryo, Nonmammalian * Ganglia, Sensory * Gene Expression Regulation, Developmental * Hair Cells, Auditory * Larva * Nerve Tissue Proteins * Nestin * Neural Stem Cells * Neurogenesis * Sensory Receptor Cells * Stem Cell Niche * Zebrafish |keywords=* Inner ear * Neuronal stem cells * PNS * Zebrafish |full-text-url=https://sci-hub.do/10.1242/dev.176750 }} ==SAT1== {{medline-entry |title=Triethylenetetramine (trientine): a caloric restriction mimetic with a new mode of action. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32544364 |keywords=* Acetylation * SAT1 * aging * autophagy * copper * metabolomics * obesity * spermidine |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469548 }} ==SATB1== {{medline-entry |title=Loss of [[SATB1]] Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31543366 |mesh-terms=* Aging * Animals * Cells, Cultured * Cellular Senescence * Cyclin-Dependent Kinase Inhibitor p21 * Dopaminergic Neurons * Epigenetic Repression * Gene Knockdown Techniques * Humans * Matrix Attachment Region Binding Proteins * Mice * Mice, Knockout * Mitosis * Parkinson Disease * Protein Binding |keywords=* Parkinson’s disease * SATB1 * cellular senescence * dopamine * neurodegeneration * neuroinflammation * p21 * senolytics * stem cells * transcriptomics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493192 }} ==SCD== {{medline-entry |title=Cognitive training and brain stimulation in prodromal Alzheimer's disease (AD-Stim)-study protocol for a double-blind randomized controlled phase IIb (monocenter) trial. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33160420 |keywords=* Aging * Decision-making * Mild cognitive impairment * Subjective cognitive decline * Transcranial direct current stimulation * Transfer * Working memory |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648990 }} {{medline-entry |title=Blood Pressure in Different Dementia Disorders, Mild Cognitive Impairment, and Subjective Cognitive Decline. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33110409 |keywords=* Alzheimer’s disease * aging * blood pressure * mild cognitive impairment * subjective cognitive decline |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7488384 }} {{medline-entry |title=Known-Groups and Convergent Validity of the Telephone Rey Auditory Verbal Learning Test total Learning Scores for Distinguishing Between Older Adults With Amnestic Cognitive Impairment and Subjective Cognitive Decline. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33067996 |keywords=* aging * cognitive impairment * neuropsychological assessment |full-text-url=https://sci-hub.do/10.1093/arclin/acaa085 }} {{medline-entry |title=Subjective cognitive decline as a predictor of future cognitive decline: a systematic review. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32973979 |keywords=* Alzheimer disease. * aging * cognition * cognitive dysfunction * dementia |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500809 }} {{medline-entry |title=Geriatric assessment for older adults with sickle cell disease: protocol for a prospective cohort pilot study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32974042 |keywords=* Aging * Functional assessment * Geriatric assessment * Geriatrics * Older adults * Sickle cell |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495855 }} {{medline-entry |title=Prevalence and psychosocial correlates of subjectively perceived decline in five cognitive domains: Results from a population-based cohort study in Germany. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32510658 |keywords=* Germany * cognitive aging * cognitive complaints * cohort study * prevalence * subjective cognitive decline |full-text-url=https://sci-hub.do/10.1002/gps.5359 }} {{medline-entry |title=SC411 treatment can enhance survival in a mouse model of sickle cell disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32447175 |keywords=* Aging * Cerebral blood flow * Docosahexaenoic acid * Neuroinflammation * Sickle cell disease * Working memory |full-text-url=https://sci-hub.do/10.1016/j.plefa.2020.102110 }} {{medline-entry |title=DNA fragmentation of human spermatozoa: Simple assessment of single- and double-strand DNA breaks and their respective dynamic behavioral response. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32416007 |keywords=* DNA longevity * sperm DNA damage * sperm DNA dynamics * sperm DNA fragmentation * sperm chromatin dispersion test |full-text-url=https://sci-hub.do/10.1111/andr.12819 }} {{medline-entry |title=Psychometric Cognitive Decline Precedes the Advent of Subjective Cognitive Decline in the Evolution of Alzheimer's Disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32388509 |keywords=* Alzheimer’s disease * Brain aging * Cognitive decline * Cognitive testing * Longitudinal studies * Psychometric cognition |full-text-url=https://sci-hub.do/10.1159/000507286 }} {{medline-entry |title=Serum alkaline phosphatase is elevated and inversely correlated with cognitive functions in subjective cognitive decline: results from the ReGAl 2.0 project. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32363431 |keywords=* Aging * Biochemistry * Cognition * Dementia * Geriatric medicine |full-text-url=https://sci-hub.do/10.1007/s40520-020-01572-6 }} {{medline-entry |title=Changes in Activity Participation Among Older Adults With Subjective Cognitive Decline or Objective Cognitive Deficits. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32010049 |keywords=* activity participation * aging * daily functioning * metamemory * subjective cognitive decline |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974583 }} {{medline-entry |title=Age, gender and drug therapy influences on Tpeak-tend interval and on electrical risk score. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32023499 |keywords=* Aging * Electrical risk score * Gender * Mortality * QTc * Repolarization phase * T peak-tend interval |full-text-url=https://sci-hub.do/10.1016/j.jelectrocard.2020.01.009 }} {{medline-entry |title=Comorbid Chronic Conditions Among Older Adults with Subjective Cognitive Decline, United States, 2015-2017. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31915725 |keywords=* Aging * Chronic disease * Cognitive dysfunction * Dementia |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938465 }} {{medline-entry |title=Resting State BOLD Variability Is Linked to White Matter Vascular Burden in Healthy Aging but Not in Older Adults With Subjective Cognitive Decline. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31920589 |keywords=* Alzheimer’s disease * aging * biomarkers * cerebrovascular health * signal variability * subjective cognitive decline * white matter |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6936515 }} {{medline-entry |title=Estimated Life Expectancy and Income of Patients With Sickle Cell Disease Compared With Those Without Sickle Cell Disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31730182 |mesh-terms=* Adolescent * Adult * Aged * Anemia, Sickle Cell * Child * Child, Preschool * Cohort Studies * Female * Forecasting * Humans * Income * Infant * Life Expectancy * Male * Middle Aged * Models, Statistical * Quality-Adjusted Life Years * United States * Young Adult |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902797 }} {{medline-entry |title=Does Empirically Derived Classification of Individuals with Subjective Cognitive Complaints Predict Dementia? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31703450 |keywords=* Compostela aging study * cluster analysis * cognitive aging * dementia * mild cognitive impairment * screening and diagnosis * subjective cognitive complaints |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895967 }} {{medline-entry |title=Spatiotemporal Oscillatory Patterns During Working Memory Maintenance in Mild Cognitive Impairment and Subjective Cognitive Decline. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31522594 |mesh-terms=* Aged * Aging * Brain Waves * Cerebral Cortex * Cognitive Dysfunction * Cortical Synchronization * Female * Humans * Magnetoencephalography * Male * Memory, Short-Term * Task Performance and Analysis |keywords=* Alzheimer’s disease (AD) * Induced oscillatory activity * magnetoencephalography (MEG) * mild cognitive impairment (MCI) * subjective cognitive decline (SCD) * working memory (WM) |full-text-url=https://sci-hub.do/10.1142/S0129065719500199 }} {{medline-entry |title=Microstructural Correlates and Laterality Effect of Prospective Memory in Non-Demented Adults with Memory Complaints. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31466053 |mesh-terms=* Aged * Aged, 80 and over * Corpus Callosum * Diffusion Tensor Imaging * Female * Frontal Lobe * Functional Laterality * Humans * Magnetic Resonance Imaging * Male * Memory Disorders * Middle Aged * Nerve Fibers * Neuropsychological Tests * Retrospective Studies * Surveys and Questionnaires * Taiwan |keywords=* Aging * Alzheimer’s disease * Cognitive complaints * Diffusion tensor imaging * Lateralization * Prospective memory * Tract-based spatial statistics |full-text-url=https://sci-hub.do/10.1159/000501366 }} ==SCN2A== {{medline-entry |title=Na 1.2 haploinsufficiency in Scn2a knock-out mice causes an autistic-like phenotype attenuated with age. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31501495 |mesh-terms=* Aging * Animals * Autism Spectrum Disorder * Gene Knockout Techniques * Haploinsufficiency * Memory * Mice * NAV1.2 Voltage-Gated Sodium Channel * Phenotype * Spatial Learning |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733925 }} ==SCN2B== {{medline-entry |title=MicroRNA‑449a regulates the progression of brain aging by targeting [[SCN2B]] in SAMP8 mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32124967 |mesh-terms=* Aging * Animals * Brain * Gene Expression Regulation * Male * Mice * Mice, Transgenic * MicroRNAs * Voltage-Gated Sodium Channel beta-2 Subunit |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053848 }} ==SCO1== {{medline-entry |title=Real-Time PCR Analysis of Metabolism-Related Genes in a Long-Lived Model of C. elegans. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32219749 |keywords=* Caenorhabditis elegans * Energy metabolism * Longevity * TaqMan real-time PCR * p53/CEP-1 |full-text-url=https://sci-hub.do/10.1007/978-1-0716-0471-7_12 }} ==SDC1== {{medline-entry |title=Olmesartan alleviates bleomycin-mediated vascular smooth muscle cell senescence via the miR-665/[[SDC1]] axis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33042414 |keywords=* Atherosclerosis * MiR-665 * SDC1 * olmesartan * vascular smooth muscle cell senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7540088 }} {{medline-entry |title=Sulfated syndecan 1 is critical to preventing cellular senescence by modulating fibroblast growth factor receptor endocytosis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32530114 |keywords=* FGFR1 * SDC1 * cellular senescence * endocytosis * heparan sulfation |full-text-url=https://sci-hub.do/10.1096/fj.201902714R }} ==SDHB== {{medline-entry |title=Mitochondrial Signatures in Circulating Extracellular Vesicles of Older Adults with Parkinson's Disease: Results from the EXosomes in PArkiNson's Disease (EXPAND) Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32059608 |keywords=* aging * biomarkers * exosomes * mitochondrial dynamics * mitochondrial quality control * mitochondrial-derived vesicles * mitochondrial-lysosomal axis * mitophagy |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074517 }} ==SDS== {{medline-entry |title=Semiautomatic morphometric analysis of skeletal muscle obtained by needle biopsy in older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32946050 |keywords=* Aging skeletal muscle * Morphometric analysis * Myosin heavy chain * Semiautomatic muscle analysis * Skeletal muscle |full-text-url=https://sci-hub.do/10.1007/s11357-020-00266-1 }} {{medline-entry |title=Effects of late-onset dietary intake of salidroside on insulin/insulin-like growth factor-1 (IGF-1) signaling pathway of the annual fish Nothobranchius guentheri. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32858432 |keywords=* Aging * Annual fish * Lifespan * Nothobranchius * Salidroside |full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104233 }} {{medline-entry |title=Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32831297 |mesh-terms=* Aging * Animals * Caenorhabditis elegans * Caenorhabditis elegans Proteins * Longevity * Protein Aggregates * Proteome * Proteomics * Workflow |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7519758 }} {{medline-entry |title=Skeletal Muscle Myofibrillar Protein Abundance Is Higher in Resistance-Trained Men, and Aging in the Absence of Training May Have an Opposite Effect. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31936810 |keywords=* aging * myofibrillar protein * proteomics * resistance training * sarcoplasmic protein |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022975 }} {{medline-entry |title=Characterization, evaluation of nutritional parameters of Radix isatidis protein and its antioxidant activity in D-galactose induced ageing mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31694618 |mesh-terms=* Aging * Animals * Antioxidants * Catalase * Drugs, Chinese Herbal * Galactose * Humans * Kidney * Liver * Male * Malondialdehyde * Mice * Mice, Inbred ICR * Molecular Weight * Oxidative Stress * Plant Proteins * Plant Roots * Superoxide Dismutase |keywords=* Antioxidant activity * D-galactose * Oxidative damage * Protein composition * Radix isatidis protein |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836523 }} {{medline-entry |title=[Effects of silver nanoparticles on pupation, eclosion, life span, apoptosis and protein expression in Drosophila melanogaster]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31621246 |mesh-terms=* Animals * Apoptosis * Drosophila melanogaster * Longevity * Metal Nanoparticles * Oregon * Silver |keywords=* Drosophila melanogaster * apoptosis * protein expression * silver nanoparticles |full-text-url=https://sci-hub.do/10.13287/j.1001-9332.201910.036 }} {{medline-entry |title=Does an Age-Specific Treatment Program Augment the Efficacy of a Cognitive-Behavioral Weight Loss Program in Adolescence and Young Adulthood? Results from a Controlled Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31480678 |mesh-terms=* Adolescent * Aging * Behavior Therapy * Cognitive Behavioral Therapy * Female * Humans * Male * Weight Loss * Weight Reduction Programs * Young Adult |keywords=* adolescents * behavioral weight loss * controlled trial * emerging adults * obesity * quality of life |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769959 }} ==SELENBP1== {{medline-entry |title=A Caenorhabditis elegans ortholog of human selenium-binding protein 1 is a pro-aging factor protecting against selenite toxicity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31557719 |mesh-terms=* Animals * Caenorhabditis elegans * Caenorhabditis elegans Proteins * Cytoplasm * Drug Resistance * Gene Expression Regulation * Humans * Longevity * Membrane Proteins * Oxidative Stress * Paraquat * Selenious Acid * Selenium-Binding Proteins * Structural Homology, Protein |keywords=* Caenorhabditis elegans * Lifespan * Selenium-binding protein * Stress signaling |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812014 }} ==SELENOK== {{medline-entry |title=Dietary selenium deficiency and supplementation differentially modulate the expression of two ER-resident selenoproteins (selenoprotein K and selenoprotein M) in the ovaries of aged mice: Preliminary data. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32736983 |keywords=* Female fertility * Ovarian aging * Selenium * Selenoprotein K * Selenoprotein M |full-text-url=https://sci-hub.do/10.1016/j.repbio.2020.07.006 }} ==SENP6== {{medline-entry |title=Molecular signature for senile and complicated cataracts derived from analysis of sumoylation enzymes and their substrates in human cataract lenses. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32827359 |keywords=* Pax6 * SUMO1 * SUMO2/3 * aging * apoptosis * cataract * de-sumoylation enzymes (SENPs) * sumoylation ligases |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576240 }} ==SERPINE1== {{medline-entry |title=Elevated circulating HtrA4 in preeclampsia may alter endothelial expression of senescence genes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32056555 |keywords=* Endothelial aging * Endothelial cells * HtrA4 * Preeclampsia * Senescence |full-text-url=https://sci-hub.do/10.1016/j.placenta.2019.12.012 }} ==SESN2== {{medline-entry |title=Copy Number Alterations in Papillary Thyroid Carcinomas: Does Loss of [i][[SESN2]][/i] Have a Role in Age-related Different Prognoses? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32859642 |keywords=* Papillary thyroid cancer * SESN2 * aCGH * deletion * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7472442 }} ==SFN== {{medline-entry |title=The phytoprotective agent sulforaphane prevents inflammatory degenerative diseases and age-related pathologies via Nrf2-mediated hormesis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33160067 |keywords=* Aging * Hormesis * Inflammation * Neuroprotection * Nrf2 * Sulforaphane |full-text-url=https://sci-hub.do/10.1016/j.phrs.2020.105283 }} {{medline-entry |title=Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33003447 |keywords=* aging * biomarkers * gut microbiome * metabolome * sulforaphane |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599699 }} {{medline-entry |title=Sulforaphane controls the release of paracrine factors by keratinocytes and thus mitigates particulate matter-induced premature skin aging by suppressing melanogenesis and maintaining collagen homeostasis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32659677 |keywords=* Coculture system * Collagen homeostasis * Melanogenesis * Particulate matter 2.5 * Premature skin aging * Sulforaphane |full-text-url=https://sci-hub.do/10.1016/j.phymed.2020.153276 }} {{medline-entry |title=Sulforaphane Inhibits Autophagy and Induces Exosome-Mediated Paracrine Senescence via Regulating mTOR/TFE3. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32476238 |keywords=* ROS * autophagy * exosome * senescence * sulforaphane |full-text-url=https://sci-hub.do/10.1002/mnfr.201901231 }} ==SFPQ== {{medline-entry |title=Downregulation of LncRNA NORAD promotes Ox-LDL-induced vascular endothelial cell injury and atherosclerosis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32267831 |keywords=* IL-8 * NORAD * cell apoptosis * cell senescence * ox-LDL |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185106 }} ==SGK1== {{medline-entry |title=Epigenetic Regulation of KL (Klotho) via H3K27me3 (Histone 3 Lysine [K] 27 Trimethylation) in Renal Tubule Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32223380 |keywords=* AKT * EZH2 * aging * mTOR * p53 |full-text-url=https://sci-hub.do/10.1161/HYPERTENSIONAHA.120.14642 }} ==SHBG== {{medline-entry |title=Endogenous Testosterone Levels and the Risk of Incident Cardiovascular Events in Elderly Men: The MrOS Prospective Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32337470 |keywords=* aging * cardiovascular events * men * testosterone |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173399 }} {{medline-entry |title=Associations of Endogenous Sex Hormones with Carotid Plaque Burden and Characteristics in Midlife Women. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31900485 |keywords=* aging * atherosclerosis * carotid artery * hormones * women |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077951 }} {{medline-entry |title=Analysis of the Relationship between the Levels of Androgens and Biochemical Bone Markers in Men Aged 60-75 Years. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31877849 |mesh-terms=* Absorptiometry, Photon * Aged * Aging * Androgens * Biomarkers * Bone Density * Bone Remodeling * Bone and Bones * Collagen Type I * Dehydroepiandrosterone Sulfate * Estradiol * Humans * Male * Middle Aged * Parathyroid Hormone * Peptide Fragments * Peptides * Procollagen * Sex Hormone-Binding Globulin * Testosterone |keywords=* aging men * biochemical bone markers * levels of androgens |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982106 }} {{medline-entry |title=Testosterone and Estrone Increase From the Age of 70 Years: Findings From the Sex Hormones in Older Women Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31408149 |mesh-terms=* Aged * Aged, 80 and over * Aging * Biomarkers * Community-Based Participatory Research * Cross-Sectional Studies * Dehydroepiandrosterone * Estrone * Female * Follow-Up Studies * Humans * Obesity * Overweight * Prognosis * Testosterone |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830527 }} ==SHD== {{medline-entry |title=Does self-reported hearing difficulty decrease older adults' cognitive and physical functioning? The mediating role of social isolation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33036703 |mesh-terms=* Activities of Daily Living * Aged * Aged, 80 and over * Cognition * Cognitive Dysfunction * Cohort Studies * Disabled Persons * Female * Health Status * Hearing Loss * Humans * Longevity * Longitudinal Studies * Male * Mental Status and Dementia Tests * Odds Ratio * Self Report * Social Isolation |keywords=* Cognitive impairment * Older people * Physical disability * Self-reported hearing difficulty * Social isolation |full-text-url=https://sci-hub.do/10.1016/j.maturitas.2020.06.011 }} ==SHH== {{medline-entry |title=Recent advances in [[SHH]] medulloblastoma progression: tumor suppressor mechanisms and the tumor microenvironment. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31700613 |mesh-terms=* Animals * Cerebellar Neoplasms * Cerebellum * Hedgehog Proteins * Humans * Medulloblastoma * Mice * Tumor Microenvironment |keywords=* Medulloblastoma * Sonic hedgehog * cell senescence * tumor microenvironment * tumor progression |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820827 }} ==SI== {{medline-entry |title=Microarray Profiling Reveals Distinct Circulating miRNAs in Aged Male and Female Mice Subjected to Post-stroke Social Isolation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33074466 |keywords=* Aging * Biomarkers * Sex differences * Social isolation * Stroke * miRNAs |full-text-url=https://sci-hub.do/10.1007/s12017-020-08622-2 }} {{medline-entry |title=Is Heart Rate a Confounding Factor for Photoplethysmography Markers? A Systematic Review. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32290168 |mesh-terms=* Aging * Cardiovascular Diseases * Diabetes Mellitus, Type 2 * Female * Fingers * Heart Rate * Humans * Male * Microcirculation * Photoplethysmography * Vascular Stiffness |keywords=* cardiovascular disease * heart rate * photoplethysmography * reflection index * second derivative of photoplethysmography * stiffness index |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177218 }} {{medline-entry |title=Survival time after marked reduction in oral intake in terminally ill noncancer patients: A retrospective study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32161695 |keywords=* elderly * geriatrics * palliative medicine |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060293 }} {{medline-entry |title=Adherence to Mediterranean diet moderates the association between multimorbidity and depressive symptoms in older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32109694 |mesh-terms=* Aged * Aged, 80 and over * Cohort Studies * Depression * Diet, Mediterranean * Healthy Aging * Humans * Multimorbidity * Surveys and Questionnaires |keywords=* Aging * Depressive symptoms * Mediterranean diet * Mental health * Multimorbidity |full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104022 }} {{medline-entry |title=Loneliness, Social Isolation, and Objectively Measured Physical Activity in Rural-Living Older Adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31860831 |keywords=* accelerometry * aging * health * social well-being * volunteering |full-text-url=https://sci-hub.do/10.1123/japa.2019-0027 }} {{medline-entry |title=The associations between social support and negative social interaction with suicidal ideation in US Chinese older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31650846 |keywords=* Chinese American * Social support * aging * negative social interaction * suicidal ideation |full-text-url=https://sci-hub.do/10.1080/13607863.2019.1680953 }} {{medline-entry |title=Cell Senescence and Cerebral Small Vessel Disease in the Brains of People Aged 80 Years and Older. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31553444 |mesh-terms=* Aged, 80 and over * Aging * Brain * Cellular Senescence * Cerebral Arteries * Cerebral Small Vessel Diseases * Female * Humans * Male * White Matter |keywords=* Brain aging * Cerebrovascular disease * Senescence * Small vessel disease |full-text-url=https://sci-hub.do/10.1093/jnen/nlz088 }} ==SIK3== {{medline-entry |title=Quantitative and Qualitative Role of Antagonistic Heterogeneity in Genetics of Blood Lipids. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31566214 |keywords=* Age-related phenotypes * Aging * Genome-wide association studies * Health span * Life span * Pleiotropy |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518561 }} ==SIRT1== {{medline-entry |title=Anthocyanins attenuate endothelial dysfunction through regulation of uncoupling of nitric oxide synthase in aged rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33274583 |keywords=* NO * SIRT1 * anthocyanins * eNOS deacetylation * senescence |full-text-url=https://sci-hub.do/10.1111/acel.13279 }} {{medline-entry |title=Sirtuins and Their Implications in Neurodegenerative Diseases from a Drug Discovery Perspective. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33280374 |keywords=* Aging * neurodegenerative diseases * neuroprotective * sirtuin * sirtuin activators * sirtuin inhibitors |full-text-url=https://sci-hub.do/10.1021/acschemneuro.0c00696 }} {{medline-entry |title=Effects of alpha-mangostin on memory senescence induced by high glucose in human umbilical vein endothelial cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33149857 |keywords=* Cellular senescence * Diabetes * Diabetes complications * Endothelial cells * Garcinia mangostana * Hyperglycemia * Mangostin * Metabolic syndrome |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585532 }} {{medline-entry |title=[[SIRT1]] Activation Using CRISPR/dCas9 Promotes Regeneration of Human Corneal Endothelial Cells through Inhibiting Senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33158256 |keywords=* CRISPR/dCas9 * SIRT1 * corneal endothelial cells * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694272 }} {{medline-entry |title=Histone Deacetylase [[SIRT1]], Smooth Muscle Cell Function, and Vascular Diseases. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33117155 |keywords=* SIRT1 * SIRT1 activators * calorie restriction * senescence * vascular diseases * vascular smooth muscle cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573826 }} {{medline-entry |title=6,4'-dihydroxy-7-methoxyflavanone protects against H O -induced cellular senescence by inducing [[SIRT1]] and inhibiting phosphatidylinositol 3-kinase/Akt pathway activation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33111210 |keywords=* 6,4′-dihydroxy-7-methoxyflavanone * Akt * Oxidative stress * Premature senescence * SIRT1 |full-text-url=https://sci-hub.do/10.1007/s11010-020-03951-z }} {{medline-entry |title=Isoparvifuran isolated from Dalbergia odorifera attenuates H O -induced senescence of BJ cells through [[SIRT1]] activation and AKT/mTOR pathway inhibition. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33010892 |keywords=* AKT/mTOR signaling pathway * Antioxidant: SIRT1 * Cellular senescence * Isoparvifuran |full-text-url=https://sci-hub.do/10.1016/j.bbrc.2020.09.096 }} {{medline-entry |title=[[SIRT1]] Is the Target Gene for 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside Alleviating the HUVEC Senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33013385 |keywords=* 2,3,5,4’-tetrahydroxystilbene-2-O-β-d-glucoside * SIRT1 * human umbilical vein cells * hydrogen peroxide * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508177 }} {{medline-entry |title=The Role of Sirtuins in Kidney Diseases. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32932720 |keywords=* acute kidney injury * aging kidney * chronic kidney disease * diabetic nephropathy * kidney * sirtuins |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555196 }} {{medline-entry |title=The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32919015 |keywords=* Cellular senescence * Elderly * Resistance training |full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111090 }} {{medline-entry |title=Virus-Induced Asthma Exacerbations: [[SIRT1]] Targeted Approach. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32823491 |keywords=* SIRT1 * asthma * cellular senescence * exacerbations * virus infection |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464235 }} {{medline-entry |title=Novel resveratrol derivatives have diverse effects on the survival, proliferation and senescence of primary human fibroblasts. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32793997 |keywords=* Resveratrol * SIRT1 * Senescence * Toxicity |full-text-url=https://sci-hub.do/10.1007/s10522-020-09896-6 }} {{medline-entry |title=Glucose restriction delays senescence and promotes proliferation of HUVECs via the AMPK/[[SIRT1]]-FOXA3-Beclin1 pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32768436 |keywords=* Beclin1 * Endothelial cells * FOXA3 * Glucose restriction * Proliferation * Senescence |full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111053 }} {{medline-entry |title=Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32722945 |keywords=* Sirtuin 1 * alveolar epithelial cells * cellular senescence * chronic obstructive pulmonary disease * cigarette smoking |full-text-url=https://sci-hub.do/10.1080/15412555.2020.1797657 }} {{medline-entry |title=Latifolin Inhibits Oxidative Stress-Induced Senescence via Upregulation of [[SIRT1]] in Human Dermal Fibroblasts. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32404543 |keywords=* human dermal fibroblast * latifolin * mammalian target of rapamycin * oxidative stress * senescence * silent information regulator 1 |full-text-url=https://sci-hub.do/10.1248/bpb.b20-00094 }} {{medline-entry |title=SRT1720-induced activation of [[SIRT1]] alleviates vascular smooth muscle cell senescence through PKA-dependent phosphorylation of AMPKα at Ser485. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32421926 |keywords=* SIRT1 * SRT1720 * VSMC senescence * p-AMPK (Ser485) * telomere length |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327920 }} {{medline-entry |title=miR-128 plays a critical role in murine osteoclastogenesis and estrogen deficiency-induced bone loss. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32292498 |keywords=* PMOP * aging * inflammation * miR-128 * osteoclastogenesis * ovariectomy |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150474 }} {{medline-entry |title=Lymphocyte senescence in COPD is associated with decreased sirtuin 1 expression in steroid resistant pro-inflammatory lymphocytes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32270742 |keywords=* CD28nullCD8+ T and NKT-like cells * COPD * IFNγ and TNFα * SIRT1 * lymphocyte senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153179 }} {{medline-entry |title=Therapeutic effects of hydro-alcoholic leaf extract of Withania somnifera on age-induced changes in daily rhythms of Sirt1, Nrf2 and Rev-erbα in the SCN of male Wistar rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32249404 |keywords=* Aging * Ashwagandha * Circadian clock * NRF2 * SCN * SIRT1 |full-text-url=https://sci-hub.do/10.1007/s10522-020-09875-x }} {{medline-entry |title=The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and αKlotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32214805 |mesh-terms=* Age Factors * Aged * Aging * Biomarkers * Blood Pressure * Cardiovascular Diseases * Case-Control Studies * Diabetes Complications * Echocardiography * Female * Glucuronidase * Heart Ventricles * Humans * Kidney * Kidney Failure, Chronic * Male * Middle Aged * Renal Dialysis * Sirtuin 1 * Stroke Volume |keywords=* chronic kidney disease * hemodialysis * sirtuin1 * αKlotho |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084123 }} {{medline-entry |title=Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32158519 |keywords=* Cellular senescence * DNMT1 * SIRT1 * extracellular vesicles * microRNAs |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048230 }} {{medline-entry |title=Spatiotemporal gating of [[SIRT1]] functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32152092 |mesh-terms=* Acetylglucosamine * Aging * Animals * Fasting * Gluconeogenesis * Glycosylation * HEK293 Cells * Homeostasis * Humans * Hyperglycemia * Insulin Resistance * Liver * Male * Mice * Mice, Inbred C57BL * Obesity * Phosphorylation * Protein Processing, Post-Translational * Sirtuin 1 * Spatio-Temporal Analysis |keywords=* PGC1α * fed–fast cycle * gluconeogenesis * insulin signaling * ubiquitinylation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104039 }} {{medline-entry |title=Hydrogen Sulfide Inhibits Homocysteine-Induced Neuronal Senescence by Up-Regulation of [[SIRT1]]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32132865 |keywords=* SIRT1 * cell senescence * homocysteine * hydrogen sulfide |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053352 }} {{medline-entry |title=[[SIRT1]] and aging related signaling pathways. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32084459 |keywords=* Aging * Deacetylate * NAD(+) * SIRT1 * Signaling pathways |full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111215 }} {{medline-entry |title=Tropisetron protects against brain aging via attenuating oxidative stress, apoptosis and inflammation: The role of [[SIRT1]] signaling. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32088214 |mesh-terms=* Aging * Animals * Antioxidants * Apoptosis * Brain * Drug Administration Schedule * Galactose * Gene Expression Regulation * Inflammation * Injections, Intraperitoneal * Injections, Subcutaneous * Interleukin-6 * Male * Mice * Mitochondria * Neurons * Nitric Oxide * Oxidative Stress * Proto-Oncogene Proteins c-bcl-2 * Reactive Oxygen Species * Serotonin 5-HT3 Receptor Antagonists * Sirtuin 1 * Tropisetron * Tumor Necrosis Factor-alpha * bcl-2-Associated X Protein |keywords=* Aging * Brain * Neurotoxicity * Sirtuin 1 * Tropisetron * d-galactose |full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.117452 }} {{medline-entry |title=Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of [[SIRT1]] activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32056076 |keywords=* Aging * Geroscience * Mitochondria dysfunction * Transcriptomics * Vascular cognitive impairment |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206476 }} {{medline-entry |title=Deacetylation of MRTF-A by [[SIRT1]] defies senescence induced down-regulation of collagen type I in fibroblast cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32061777 |mesh-terms=* Acetylation * Animals * Benzamides * Carbazoles * Cellular Senescence * Collagen Type I * Down-Regulation * Embryo, Mammalian * Fibroblasts * HEK293 Cells * Heterocyclic Compounds, 4 or More Rings * Humans * Mice * Mutation * Naphthols * Primary Cell Culture * Promoter Regions, Genetic * RNA, Small Interfering * Resveratrol * Sirtuin 1 * Trans-Activators |keywords=* Collagen type I * Fibroblast * Lysine deacetylation * Post-translational modification * Senescence * Transcriptional regulation |full-text-url=https://sci-hub.do/10.1016/j.bbadis.2020.165723 }} {{medline-entry |title=Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal [[SIRT1]] Levels Improving Cognition in Aged Rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31991916 |mesh-terms=* Age Factors * Animals * Behavior, Animal * Biogenic Monoamines * Catechin * Cognition * Cognitive Aging * Corpus Striatum * Hippocampus * Male * Memory, Episodic * Memory, Short-Term * Neuroprotective Agents * Rats, Sprague-Dawley * Sirtuin 1 * Time Factors |keywords=* NF-κB * RBAP46/48 * SIRT1 * brain aging * brain monoamine synthesis * catechin * green tea * memory |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071257 }} {{medline-entry |title=Duck Oil-loaded Nanoemulsion Inhibits Senescence of Angiotensin II-treated Vascular Smooth Muscle Cells by Upregulating [[SIRT1]]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31970335 |keywords=* SIRT1 * angiotensin II * duck oil * nanoemulsion * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957441 }} {{medline-entry |title=Two novel [[SIRT1]] activators, SCIC2 and SCIC2.1, enhance [[SIRT1]]-mediated effects in stress response and senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31942817 |keywords=* Sirtuins * drug discovery * epigenetic modulators * senescence * stress response |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574383 }} {{medline-entry |title=Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31881011 |mesh-terms=* A549 Cells * Alveolar Epithelial Cells * Apoptosis * Cellular Senescence * Humans * Hydrogen Sulfide * Mitochondria * Oxidative Stress * Sirtuin 1 * Smoke * Tobacco * Up-Regulation |keywords=* alveolar epithelial cell * cigarette smoke extract * hydrogen sulfide * mitochondria injury * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949053 }} {{medline-entry |title=The protective role of omentin-1 in IL-1β-induced chondrocyte senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31852248 |mesh-terms=* Adipokines * Caveolin 1 * Cell Line, Tumor * Cellular Senescence * Chondrocytes * Cyclin-Dependent Kinase Inhibitor p21 * Cytoprotection * G1 Phase Cell Cycle Checkpoints * Humans * Interleukin-1beta * Plasminogen Activator Inhibitor 1 * Sirtuin 1 * Transcriptional Activation |keywords=* IL-1β * Omentin-1 * SIRT-1 * chondrocyte senescence |full-text-url=https://sci-hub.do/10.1080/21691401.2019.1699803 }} {{medline-entry |title=The Lifespan Extension Ability of Nicotinic Acid Depends on Whether the Intracellular NAD Level Is Lower than the Sirtuin-Saturating Concentrations. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31878234 |mesh-terms=* Animals * Caenorhabditis elegans * Caenorhabditis elegans Proteins * Caloric Restriction * Cell Line * Humans * NAD * Niacin * Sirtuins * beta-Galactosidase |keywords=* C. elegans * Hs68 cells * NAD+ * calorie restriction mimetic * lifespan * nicotinic acid |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982340 }} {{medline-entry |title=Alpha-mangostin decreased cellular senescence in human umbilical vein endothelial cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31792920 |keywords=* Alpha-mangostin * Diabetes * HUVEC * High glucose * SIRT1 * Senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214571 }} {{medline-entry |title=Central nervous system [[SIRT1]] expression is required for cued and contextual fear conditioning memory responses in aging mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31763496 |keywords=* Fear conditioning * SIRT1 * aging * classically conditioned memory * hippocampus |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839599 }} {{medline-entry |title=Does education level protect us from rapid ageing? Sirtuin expression versus age and level of education. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31785216 |mesh-terms=* Adolescent * Adult * Age Factors * Aging * Aging, Premature * Educational Status * Epigenesis, Genetic * Female * Gene Expression Regulation, Enzymologic * Histones * Humans * Learning * Male * Middle Aged * Sirtuins * Young Adult }} {{medline-entry |title=CO ameliorates endothelial senescence induced by 5-fluorouracil through [[SIRT1]] activation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31704100 |mesh-terms=* Antioxidants * Carbon Monoxide * Cellular Senescence * Down-Regulation * Fluorouracil * Heme Oxygenase-1 * Human Umbilical Vein Endothelial Cells * Humans * Nitric Oxide Synthase Type III * Reactive Oxygen Species * Sirtuin 1 |keywords=* 5-Fluorouracil * Carbon monoxide * Endothelial senescence * Reactive oxygen species * SIRT1 |full-text-url=https://sci-hub.do/10.1016/j.abb.2019.108185 }} {{medline-entry |title=Long noncoding RNA GAS5 inhibits cell proliferation and fibrosis in diabetic nephropathy by sponging miR-221 and modulating [[SIRT1]] expression. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31631065 |mesh-terms=* Aging * Animals * Argonaute Proteins * Cell Proliferation * Diabetes Mellitus, Experimental * Diabetic Nephropathies * Fibrosis * Gene Deletion * Gene Expression Regulation * Glucose * Male * Mesangial Cells * Mice * MicroRNAs * RAW 264.7 Cells * RNA, Long Noncoding * Rats * Rats, Sprague-Dawley * Sirtuin 1 |keywords=* diabetic nephropathy * fibrosis * lncRNA GAS5 * proliferation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834398 }} {{medline-entry |title=The Role of Sirtuin1 in Regulating Endothelial Function, Arterial Remodeling and Vascular Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31572218 |keywords=* PVAT * SIRT1 * eNOS * vascular aging * vascular remodeling |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751260 }} {{medline-entry |title=Deacetylation of LAMP1 drives lipophagy-dependent generation of free fatty acids by Abrus agglutinin to promote senescence in prostate cancer. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31544977 |keywords=* Abrus agglutinin * LAMP1 * SIRT1 * free fatty acid * lipophagy * reactive oxygen species * senescence |full-text-url=https://sci-hub.do/10.1002/jcp.29182 }} {{medline-entry |title=Plasma exosomes in OSA patients promote endothelial senescence: effect of long-term adherent continuous positive airway pressure. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31552414 |keywords=* CPAP * OSA * aging * cardiovascular * endothelium * exosomes * extracellular vesicles * intermittent hypoxia * oxidative stress * senescence |full-text-url=https://sci-hub.do/10.1093/sleep/zsz217 }} {{medline-entry |title=Hydrogen Sulfide Inhibits High Glucose-Induced Neuronal Senescence by Improving Autophagic Flux [i]via[/i] Up-regulation of [[SIRT1]]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31481873 |keywords=* SIRT1 * autophagic flux * high glucose * hydrogen sulfide * neuronal senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710442 }} {{medline-entry |title=Activation of the miR-34a-Mediated [[SIRT1]]/mTOR Signaling Pathway by Urolithin A Attenuates D-Galactose-Induced Brain Aging in Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31420820 |mesh-terms=* Aging * Animals * Brain * Coumarins * Galactose * Male * Mice * Mice, Inbred ICR * MicroRNAs * PC12 Cells * Random Allocation * Rats * Signal Transduction * Sirtuin 1 * TOR Serine-Threonine Kinases |keywords=* D-Gal * SIRT1/mTOR signal pathway * Urolithin A * aging * autophagy * miR-34a |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985387 }} ==SIRT2== {{medline-entry |title=Melatonin ameliorates the advanced maternal age-associated meiotic defects in oocytes through the [[SIRT2]]-dependent H4K16 deacetylation pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31980591 |keywords=* aging * histone acetylation * meiosis * melatonin * oocyte quality |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053624 }} ==SIRT3== {{medline-entry |title=[[SIRT3]] protects endothelial cells from high glucose-induced senescence and dysfunction via the p53 pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33160987 |keywords=* Endothelial senescence * High glucose * SIRT3 * p53 |full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118724 }} {{medline-entry |title=Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143333 |keywords=* aging * arterial hypertension * buccal epithelium * melatonin * sirtuins |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662974 }} {{medline-entry |title=[i][[SIRT3]][/i] Transfection of Aged Human Bone Marrow-Derived Mesenchymal Stem Cells Improves Cell Therapy-Mediated Myocardial Repair. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32228121 |keywords=* O-hMSC transplantation * SIRT3 * aging * gene modification * myocardial infarction * myocardial repair |full-text-url=https://sci-hub.do/10.1089/rej.2019.2260 }} {{medline-entry |title=17β-estradiol inhibits H O -induced senescence in HUVEC cells through upregulating [[SIRT3]] expression and promoting autophagy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32172411 |keywords=* 17β-estradiol * Autophagy * SIRT3 * Senescence |full-text-url=https://sci-hub.do/10.1007/s10522-020-09868-w }} {{medline-entry |title=CR6 interacting factor 1 deficiency induces premature senescence via [[SIRT3]] inhibition in endothelial cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32109515 |keywords=* Antioxidant system * Mitochondria * Oxidative stress * Senescence * Vascular endothelial cell |full-text-url=https://sci-hub.do/10.1016/j.freeradbiomed.2020.02.017 }} {{medline-entry |title=Mitochondrial function in skeletal myofibers is controlled by a TRF2-[[SIRT3]] axis over lifetime. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31991048 |keywords=* aging * mitochondria * postmitotic cells * skeletal muscle * telomeres |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059141 }} {{medline-entry |title=Context-Dependent Roles for SIRT2 and [[SIRT3]] in Tumor Development Upon Calorie Restriction or High Fat Diet. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31970087 |keywords=* SIRT2 * SIRT3 * aging * calorie restriction * cancer * high fat diet |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960403 }} {{medline-entry |title=The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31740222 |mesh-terms=* Aging * Animals * Cardiovascular Diseases * Humans * Metabolic Diseases * Mitochondria * Neurodegenerative Diseases * Protein Isoforms * Sirtuin 3 |keywords=* Age-related diseases * Deacetylation * Genetic manipulations * Mitochondria * Pharmacological modulators * Sirtuins |full-text-url=https://sci-hub.do/10.1016/j.arr.2019.100983 }} ==SIRT5== {{medline-entry |title=Lysine malonylation and propionylation are prevalent in human lens proteins. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31678036 |mesh-terms=* Aging * Animals * Blotting, Western * Chromatography, Liquid * Crystallins * Cytoskeletal Proteins * Cytosol * Epithelial Cells * Humans * Immunohistochemistry * Lens, Crystalline * Lysine * Malonates * Membrane Proteins * Mice, Inbred C57BL * Mice, Knockout * Middle Aged * Mitochondrial Proteins * Organ Culture Techniques * Paraffin Embedding * Propionates * Sirtuin 3 * Sirtuins * Tandem Mass Spectrometry |keywords=* Lens proteins * Malonylation * Mass spectrometry * Propionylation * Sirtuins |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957740 }} ==SIRT6== {{medline-entry |title=Association between [[SIRT6]] Methylation and Human Longevity in a Chinese Population. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33238266 |keywords=* DNA Methylation * Longevity * Messenger RNA * SIRT6 |full-text-url=https://sci-hub.do/10.1159/000508832 }} {{medline-entry |title=The [[SIRT6]] activator MDL-800 improves genomic stability and pluripotency of old murine-derived iPS cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33089974 |keywords=* DNA repair * MDL-800 * SIRT6 * aging * genome integrity * pluripotency |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431819 }} {{medline-entry |title=Sirtuins as Possible Predictors of Aging and Alzheimer's Disease Development: Verification in the Hippocampus and Saliva. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33098511 |keywords=* Alzheimer’s disease * aging * intravital diagnosis * saliva * sirtuins |full-text-url=https://sci-hub.do/10.1007/s10517-020-04986-4 }} {{medline-entry |title=Age-related epigenetic drift deregulates [i][[SIRT6]][/i] expression and affects its downstream genes in human peripheral blood mononuclear cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32573339 |keywords=* SIRT6 * aging * interaction network * longevity * methylation * miRNA * peripheral blood mononuclear cells (PBMCs) |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678931 }} {{medline-entry |title=Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32518153 |keywords=* SIRT6 * activator * aging * cancer * cell metabolism * chromatin * gene expression * histone deacetylase (HDAC) * longevity * metabolic disorder * sirtuin * small molecule |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415977 }} {{medline-entry |title=Age-dependent role of [[SIRT6]] in jawbone via regulating senescence and autophagy of bone marrow stromal cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32002721 |mesh-terms=* Adult * Aged * Aging * Animals * Bone Marrow Cells * Humans * Jaw * Male * Mesenchymal Stem Cells * Mice * Mice, Knockout * Middle Aged * Osteogenesis * Sirtuins |keywords=* Autophagy * Bone marrow stromal cells * Jawbone * Osteoporosis * SIRT6 * Senescence |full-text-url=https://sci-hub.do/10.1007/s10735-020-09857-w }} {{medline-entry |title=Mechanism of activation for the sirtuin 6 protein deacylase. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31822559 |mesh-terms=* Allosteric Regulation * Biocatalysis * Fatty Acids * HEK293 Cells * Histones * Humans * Hydrophobic and Hydrophilic Interactions * Kinetics * Lipids * Mutagenesis * Mutation * NAD * Peptides * Protein Binding * Protein Conformation * Sirtuins * Small Molecule Libraries |keywords=* SIRT6 * activator * cancer * chromatin * deacetylation * epigenetics * histone * histone deacetylase (HDAC) * lifespan * long chain acyl substrate * longevity * sirtuin |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996886 }} {{medline-entry |title=Proteomics of Long-Lived Mammals. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31737995 |keywords=* SIRT6 * aging * long-lived mammals * naked mole rats * proteomics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117992 }} {{medline-entry |title=Sirtuins and [[SIRT6]] in Carcinogenesis and in Diet. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31591350 |mesh-terms=* Aging * Animals * Carcinogenesis * Diet * Gene Expression Regulation, Neoplastic * Humans * Nanomedicine * Organ Specificity * Sirtuins |keywords=* SIRT6 * cancer * chemotherapy * diet * modulator * sirtuins |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801518 }} {{medline-entry |title=[[SIRT6]]-mediated transcriptional suppression of MALAT1 is a key mechanism for endothelial to mesenchymal transition. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31399301 |mesh-terms=* Aging * Animals * Cells, Cultured * Disease Models, Animal * Endothelium, Vascular * Epithelial-Mesenchymal Transition * Gene Expression Regulation * Male * Mice * Mice, Inbred C57BL * Mice, Knockout * RNA, Long Noncoding * Signal Transduction * Sirtuins * Vascular Diseases |full-text-url=https://sci-hub.do/10.1016/j.ijcard.2019.07.082 }} ==SIRT7== {{medline-entry |title=[[SIRT7]] antagonizes human stem cell aging as a heterochromatin stabilizer. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32504224 |keywords=* LINE1 * SIRT7 * STING * aging * cGAS * stem cell |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305295 }} ==SLA== {{medline-entry |title=Vaccination of aged mice with adjuvanted recombinant influenza nucleoprotein enhances protective immunity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32540272 |keywords=* Adjuvant * Aging * Influenza * Mouse * Nucleoprotein * Vaccination |full-text-url=https://sci-hub.do/10.1016/j.vaccine.2020.05.085 }} {{medline-entry |title=Mechanical Anisotropy and Surface Roughness in Additively Manufactured Parts Fabricated by Stereolithography ([[SLA]]) Using Statistical Analysis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32486137 |keywords=* Taguchi methods * additive manufacturing * aging effect * analysis of variance * anisotropy * design of experiments * stereolithography * surface roughness * tensile testing |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321476 }} {{medline-entry |title=The Effect of Age of Titanium Dental Implants on Implant Survival and Marginal Bone Resorption: A 5-Year Retrospective Follow-Up Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32369581 |keywords=* aged implant * biological aging * implant survival * marginal bone resorption * titanium dental implant |full-text-url=https://sci-hub.do/10.1563/aaid-joi-D-19-00316 }} ==SLC16A7== {{medline-entry |title=Genetics of facial telangiectasia in the Rotterdam Study: a genome-wide association study and candidate gene approach. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33095951 |keywords=* GWAS * KIAA0930 * MC1R * SLCA45A2 * SNP * Telangiectasia * candidate gene approach * epidemiology * genetics * pigmentation genes * red veins * skin aging |full-text-url=https://sci-hub.do/10.1111/jdv.17014 }} ==SLC26A2== {{medline-entry |title=Phenotypic characterization of Slc26a2 mutant mice reveals a multifactorial etiology of spondylolysis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31914611 |mesh-terms=* Aging * Animals * Lumbar Vertebrae * Male * Mice * Osteogenesis * Phenotype * Spondylolysis * Sulfate Transporters |keywords=* SLC26A2 * bone loss * isthmic defect * spondylolysis * vertebral development |full-text-url=https://sci-hub.do/10.1096/fj.201901040RR }} ==SLC6A4== {{medline-entry |title=The Psilocybin-Telomere Hypothesis: An empirically falsifiable prediction concerning the beneficial neuropsychopharmacological effects of psilocybin on genetic aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31634774 |mesh-terms=* Aging * Aging, Premature * Animals * Anxiety * Brain-Derived Neurotrophic Factor * Consciousness * DNA Methylation * Depression * Disease Models, Animal * Endocrine System * Humans * Models, Genetic * Models, Psychological * Neurotransmitter Agents * Oxidative Stress * Personality * Psilocybin * Psychotropic Drugs * Research Design * Serotonin Plasma Membrane Transport Proteins * Stress, Psychological * Telomere Shortening |keywords=* Cellular senescence * Depression * Epigenetic clock * Genetic aging * Life extension * Neurophenomenology * Psilocybin * Rejuvenation * Rumination * Senotherapy * Telomeres |full-text-url=https://sci-hub.do/10.1016/j.mehy.2019.109406 }} ==SMAD1== {{medline-entry |title=TGFB1-Mediated Gliosis in Multiple Sclerosis Spinal Cords Is Favored by the Regionalized Expression of HOXA5 and the Age-Dependent Decline in Androgen Receptor Ligands. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31779094 |mesh-terms=* Age Factors * Aged * Aging * Brain * Data Mining * Databases, Genetic * Disease Progression * Female * Gene Expression Profiling * Gliosis * Homeodomain Proteins * Humans * Ligands * Male * Middle Aged * Multiple Sclerosis * Proteomics * Receptors, Androgen * Sequence Analysis, RNA * Signal Transduction * Smad1 Protein * Spinal Cord * Transforming Growth Factor beta1 * Up-Regulation |keywords=* androgen receptor * astrocytes * homeobox A5 * multiple sclerosis * spinal cord * transforming growth factor beta 1 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928867 }} ==SMAD2== {{medline-entry |title=Prostate epithelial-specific expression of activated PI3K drives stromal collagen production and accumulation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31674011 |mesh-terms=* Aging * Animals * Class I Phosphatidylinositol 3-Kinases * Collagen * Disease Models, Animal * Disease Progression * Epithelium * Male * Mice, Mutant Strains * Phosphorylation * Prostate * Prostatic Hyperplasia * Prostatic Intraepithelial Neoplasia * Prostatic Neoplasms * Signal Transduction * Smad2 Protein * Stromal Cells * Transforming Growth Factor beta |keywords=* PIK3CA * cancer * collagen * fibrosis * mouse model * prostate * stroma |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071816 }} ==SMAD3== {{medline-entry |title=Sirtuin 6 deficiency transcriptionally up-regulates TGF-β signaling and induces fibrosis in mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31744885 |mesh-terms=* Aging * Animals * Fibroblasts * Fibrosis * Gene Deletion * Male * Mice * Myocardium * Myofibroblasts * Signal Transduction * Sirtuins * Smad3 Protein * Transcriptional Activation * Transforming Growth Factor beta |keywords=* SIRT6 deacetylase * SMAD transcription factor * SMAD3 * TGF-beta signaling * aging * aging-associated fibrosis * caloric restriction * cardiac disease * extracellular matrix (ECM) * fibrosis * sirtuin * transforming growth factor beta (TGF-beta) |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956532 }} ==SMN2== {{medline-entry |title=Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31589162 |mesh-terms=* Aging * Autopsy * Cell Survival * Female * Humans * Male * Motor Neurons * Muscular Atrophy, Spinal * Oligodeoxyribonucleotides, Antisense * Spinal Cord * Survival of Motor Neuron 2 Protein |keywords=* Development * Neurodegeneration * Neurodevelopment * Neuromuscular disease * Neuroscience |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819103 }} ==SMS== {{medline-entry |title=Does a Live Performance Impact Synchronization to Musical Rhythm in Cognitively Impaired Elderly? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33104027 |keywords=* Aging * Alzheimer’s disease * cognitive impairment * dementia * motor activity * music therapy * social interaction |full-text-url=https://sci-hub.do/10.3233/JAD-200521 }} {{medline-entry |title=Testing the effectiveness of physical activity advice delivered via text messaging vs. human phone advisors in a Latino population: The On The Move randomized controlled trial design and methods. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32659437 |keywords=* Aging * Digital health * Latino * Physical activity * Text-messaging * mHealth |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351675 }} ==SNAP25== {{medline-entry |title=The Biological Foundations of Sarcopenia: Established and Promising Markers. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31457015 |keywords=* SNAP25 * aging * biomarkers * neuromuscular junction * sarcopenia |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700259 }} ==SNCA== {{medline-entry |title=Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31758049 |mesh-terms=* Aging * Alanine * Amino Acid Substitution * Animals * Behavior, Animal * Disease Models, Animal * Dopaminergic Neurons * Humans * Locomotion * Male * Mice * Mice, Inbred C57BL * Mice, Transgenic * Mutation, Missense * Parkinson Disease * Proline * Threonine * alpha-Synuclein |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874660 }} ==SND1== {{medline-entry |title=[Downregulation of [[SND1]] Expression Accelerates Cell Senescence of Human Diploid Fibroblasts 2BS via Modulating the SASP]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32543144 |mesh-terms=* Cellular Senescence * Diploidy * Down-Regulation * Endonucleases * Fibroblasts * Humans * Nuclear Proteins |keywords=* Aging * Cellular senescent * SND1 * Senescence-associated-secretory-phenotype |full-text-url=https://sci-hub.do/10.12182/20200560504 }} ==SOD1== {{medline-entry |title=[[SOD1]], more than just an antioxidant. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33259795 |keywords=* Aging * Cancer * Neurodegenerative diseases * Post-translational modifications * Superoxide dismutase 1 |full-text-url=https://sci-hub.do/10.1016/j.abb.2020.108701 }} {{medline-entry |title=The Exacerbation of Aging and Oxidative Stress in the Epididymis of [i]Sod1[/i] Null Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32054065 |keywords=* 4-hydroxynonenal * 8-hydroxyguanosine * aging * epididymis * oxidative stress * reactive oxygen species * spermatozoa * superoxide dismutase |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071042 }} {{medline-entry |title=Alterations in lipid metabolism of spinal cord linked to amyotrophic lateral sclerosis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31406145 |mesh-terms=* Aging * Amyotrophic Lateral Sclerosis * Animals * Cardiolipins * Cholesterol Esters * Disease Models, Animal * Disease Progression * Fatty Acids, Unsaturated * Female * Humans * Lipid Droplets * Lipid Metabolism * Lipidomics * Male * Mass Spectrometry * Motor Cortex * Motor Neurons * Mutation * Oxidative Stress * Rats * Rats, Transgenic * Spinal Cord * Superoxide Dismutase-1 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691112 }} ==SOD2== {{medline-entry |title=Astaxanthin Counteracts Vascular Calcification In Vitro Through an Early Up-Regulation of [[SOD2]] Based on a Transcriptomic Approach. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33198315 |keywords=* aortic calcification * astaxanthin * chronic kidney disease * chronic kidney disease-mineral bone disorder * oxidative stress * reactive oxygen species * senescence * vascular calcification * vascular smooth muscle cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698184 }} {{medline-entry |title=Alginate Oligosaccharide Prevents against D-galactose-mediated Cataract in C57BL/6J Mice via Regulating Oxidative Stress and Antioxidant System. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33153341 |keywords=* Cataract * D-galactose * aging * alginate oligosaccharide * oxidative stress |full-text-url=https://sci-hub.do/10.1080/02713683.2020.1842456 }} {{medline-entry |title=Protoflavones in melanoma therapy: Prooxidant and pro-senescence effect of protoapigenone and its synthetic alkyl derivative in A375 cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32931795 |mesh-terms=* Antineoplastic Agents, Phytogenic * Autophagy * Biomarkers * Cell Cycle * Cell Line, Tumor * Cellular Senescence * Cyclohexanones * Flavones * Humans * Melanoma * Reactive Oxygen Species * Superoxide Dismutase * beta-Galactosidase |keywords=* Alkyl protoflavone * Flavonoid * Melanoma * Protoapigenone * Semi-synthesis * Senescence |full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118419 }} {{medline-entry |title=Ginsenoside Rg1 protects against Sca-1 HSC/HPC cell aging by regulating the SIRT1-FOXO3 and SIRT3-[[SOD2]] signaling pathways in a γ-ray irradiation-induced aging mice model. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32765665 |keywords=* SIRT1 * SIRT3 * aging * ginsenoside Rg1 * hematopoietic progenitor cells * hematopoietic stem cells * senescence * γ-ray irradiation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388550 }} {{medline-entry |title=Almond Skin Extracts and Chlorogenic Acid Delay Chronological Aging and Enhanced Oxidative Stress Response in Yeast. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32481725 |keywords=* 8-Oxo-guanine * aging * almond * chlorogenic acid * lipid peroxidation * mitochondria * oxidative stress * protein carbonylation * sirtuin * superoxide dismutase * yeast |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345664 }} {{medline-entry |title=Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32427102 |keywords=* AKT * aging * apoptosis * cell biology * p53 * regenerative medicine * senescence * stem cells * telomeres * zebrafish |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237213 }} {{medline-entry |title=Bioactive peptides derived from crimson snapper and in vivo anti-aging effects on fat diet-induced high fat Drosophila melanogaster. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31844865 |mesh-terms=* Aging * Animal Scales * Animals * Catalase * Diet, High-Fat * Disease Models, Animal * Drosophila Proteins * Drosophila melanogaster * Female * Fish Proteins * Fishes * Humans * Longevity * Male * Malondialdehyde * Oxidative Stress * Peptides * Superoxide Dismutase |full-text-url=https://sci-hub.do/10.1039/c9fo01414d }} {{medline-entry |title=Ellagic acid prolongs the lifespan of Drosophila melanogaster. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31786733 |keywords=* Drosophila melanogaster * Ellagic acid * Gene expression * Longevity * Stress |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031466 }} {{medline-entry |title=Chlorella vulgaris modulates the expression of senescence-associated genes in replicative senescence of human diploid fibroblasts. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31642042 |mesh-terms=* Antioxidants * Catalase * Cell Differentiation * Cell Proliferation * Cells, Cultured * Cellular Senescence * Chlorella vulgaris * DNA Damage * Diploidy * Fibroblasts * Gene Expression * Genes, p53 * Humans * Male * Mitogen-Activated Protein Kinase 14 * Molecular Chaperones * Primary Cell Culture * Signal Transduction * Superoxide Dismutase * Superoxide Dismutase-1 |keywords=* Chlorella vulgaris * Fibroblasts * Replicative senescence * Senescence-associated genes |full-text-url=https://sci-hub.do/10.1007/s11033-019-05140-8 }} {{medline-entry |title=Age-Associated Changes in Antioxidants and Redox Proteins of Rat Heart. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31647296 |mesh-terms=* Aging * Animals * Antioxidants * Glutathione Peroxidase * Male * Myocardium * Oxidation-Reduction * Rats * Rats, Wistar * Superoxide Dismutase |full-text-url=https://sci-hub.do/10.33549/physiolres.934170 }} {{medline-entry |title=Impact of curcumin on replicative and chronological aging in the Saccharomyces cerevisiae yeast. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31659616 |keywords=* Aging * Curcumin * Hypertrophy * Oxidative stress * Yeast |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942599 }} ==SOX13== {{medline-entry |title=In silico analysis of human renin gene-gene interactions and neighborhood topologically associated domains suggests breakdown of insulators contribute to ageing-associated diseases. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31520345 |mesh-terms=* Aging * Computer Simulation * Epistasis, Genetic * Humans * Promoter Regions, Genetic * Renin |keywords=* Aging * Diseases of aging * Gene expression * Gene–gene interaction * Genomics * Longevity * Renin-angiotensin system * Topologically associated domains |full-text-url=https://sci-hub.do/10.1007/s10522-019-09834-1 }} ==SOX2== {{medline-entry |title=Multiple nanosecond pulsed electric fields stimulation with conductive poly(l-lactic acid)/carbon nanotubes films maintains the multipotency of mesenchymal stem cells during prolonged in vitro culture. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32592324 |keywords=* cell physical stimulus * differentiation * mesenchymal stem cells * multipotency * nanosecond pulsed electric fields * senescence |full-text-url=https://sci-hub.do/10.1002/term.3088 }} {{medline-entry |title=Subpopulations of miniature pig mesenchymal stromal cells with different differentiation potentials differ in the expression of octamer-binding transcription factor 4 and sex determining region Y-box 2. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32054231 |keywords=* Aging * Mesenchymal Stromal Cell (MSC) Subpopulations * Miniature Pig * Octamerbinding Transcription Factor 4 (OCT4) * Sex Determining Region Y-box 2 (SOX2) |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054621 }} {{medline-entry |title=Increased Type I and Decreased Type II Hair Cells after Deletion of Sox2 in the Developing Mouse Utricle. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31678344 |mesh-terms=* Aging * Animals * Cell Count * Cell Differentiation * Cell Lineage * Hair Cells, Vestibular * Mice * Mice, Knockout * Mice, Transgenic * SOXB1 Transcription Factors * Saccule and Utricle |keywords=* SOX2 * balance disorder * hair cell * utricle * vestibule |full-text-url=https://sci-hub.do/10.1016/j.neuroscience.2019.09.027 }} ==SOX4== {{medline-entry |title=Age-induced accumulation of methylmalonic acid promotes tumour progression. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32814897 |mesh-terms=* Adult * Aged * Aging * Animals * Cell Line, Tumor * Disease Progression * Female * Gene Expression Regulation, Neoplastic * Humans * Male * Methylmalonic Acid * Mice * Middle Aged * Neoplasm Invasiveness * Neoplasm Metastasis * Neoplasms * SOXC Transcription Factors * Signal Transduction * Transcriptome * Transforming Growth Factor beta |full-text-url=https://sci-hub.do/10.1038/s41586-020-2630-0 }} ==SOX9== {{medline-entry |title=Positive Effects of a Young Systemic Environment and High Growth Differentiation Factor 11 Levels on Chondrocyte Proliferation and Cartilage Matrix Synthesis in Old Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32067417 |mesh-terms=* Adolescent * Aged * Aging * Animals * Arthroplasty, Replacement, Knee * Bone Morphogenetic Proteins * Cartilage, Articular * Cell Proliferation * Chondrocytes * Collagen Type II * Collagen Type X * Core Binding Factor Alpha 1 Subunit * Extracellular Matrix * Female * Growth Differentiation Factors * Humans * In Vitro Techniques * Knee Joint * Male * Matrix Metalloproteinase 13 * Mice * Osteoarthritis, Knee * Parabiosis * Phosphorylation * RNA, Messenger * Reverse Transcriptase Polymerase Chain Reaction * SOX9 Transcription Factor * Smad2 Protein * Smad3 Protein * Stifle * Young Adult |full-text-url=https://sci-hub.do/10.1002/art.41230 }} ==SPARC== {{medline-entry |title=[[SPARC]] Metrics Provide Mobility Smoothness Assessment in Oldest-Old With and Without a History of Falls: A Case Control Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32587523 |keywords=* aging * falls * functional mobility * movement smoothness * oldest-old |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298141 }} {{medline-entry |title=Reduced fibrillar collagen accumulation in skeletal muscle of secreted protein acidic and rich in cysteine ([[SPARC]])-null mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31582603 |mesh-terms=* Aging * Animals * Fibrillar Collagens * Gene Expression * Male * Mice * Mice, Knockout * Muscle, Skeletal * Myofibrils * Osteonectin |keywords=* Secreted protein acidic and rich in cysteine * collagen * fibrosis * myofiber * skeletal muscle |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895640 }} ==SPR== {{medline-entry |title=Regulation of lifespan by neural excitation and REST. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31619788 |mesh-terms=* Aging * Animals * Brain * Caenorhabditis elegans * Caenorhabditis elegans Proteins * DNA-Binding Proteins * Forkhead Transcription Factors * Humans * Longevity * Mice * Mice, 129 Strain * Mice, Inbred C57BL * Mice, Knockout * Mice, Transgenic * Neurons * RNA Interference * RNA-Binding Proteins * Repressor Proteins * Transcription Factors |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893853 }} ==SPRTN== {{medline-entry |title=Tandem Deubiquitination and Acetylation of [[SPRTN]] Promotes DNA-Protein Crosslink Repair and Protects against Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32649882 |mesh-terms=* Acetylation * Aging * Animals * Cell Line * DNA Damage * DNA Repair * DNA-Binding Proteins * Deubiquitinating Enzymes * Endopeptidases * Female * Genomic Instability * HEK293 Cells * Humans * Male * Mice, Inbred C57BL * Mice, Knockout * Phosphorylation * Protein Domains * Protein Processing, Post-Translational * Ubiquitination |keywords=* DNA repair * DNA-protein crosslink * SPRTN * Top1cc * VCPIP1/VCIP135 * acetylation * aging * genomic instability * metalloprotease * ubiquitination |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484104 }} ==SPRY1== {{medline-entry |title=Sprouty1 Prevents Cellular Senescence Maintaining Proliferation and Differentiation Capacity of Human Adipose Stem/Progenitor Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32304210 |keywords=* Adipogenesis * Adipose stem cell * Obesity * Senescence * Sprouty1 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662188 }} {{medline-entry |title=Mechanism of [[SPRY1]] methylation regulating natural aging of skin epidermal cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31483543 |keywords=* SPRY1 * methylation * natural aging * skin epidermal aging |full-text-url=https://sci-hub.do/10.1111/jocd.13126 }} ==SQSTM1== {{medline-entry |title=The selective autophagy receptor [[SQSTM1]]/p62 improves lifespan and proteostasis in an evolutionarily conserved manner. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32041473 |keywords=* Aging * C. elegans * Drosophila * SQST-1 * SQSTM1 * aggrephagy * heat shock * mitophagy * p62 * proteostasis * ref(2)P * selective autophagy |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138197 }} ==SRC== {{medline-entry |title=Metabolic characteristics of CD8 T cell subsets in young and aged individuals are not predictive of functionality. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32504069 |mesh-terms=* Adult * Aged * Aging * Animals * CD8-Positive T-Lymphocytes * Cell Differentiation * Cell Proliferation * Disease Models, Animal * Female * Humans * Immunologic Memory * Influenza A virus * Influenza, Human * Male * Mice * Microscopy, Electron, Transmission * Mitochondria * T-Lymphocyte Subsets * Young Adult |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275080 }} ==SRD5A2== {{medline-entry |title=Extract of Plumbago zeylanica enhances the growth of hair follicle dermal papilla cells with down-regulation of 5α-reductase type II. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32125089 |keywords=* P zeylanica * 5α-reductase * dermal papilla * hair * plumbagin * senescence |full-text-url=https://sci-hub.do/10.1111/jocd.13355 }} ==SRF== {{medline-entry |title=Changes in snail and [[SRF]] expression in the kidneys of diabetic rats during ageing. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31668740 |mesh-terms=* Aging * Animals * Diabetes Mellitus, Experimental * Diabetic Nephropathies * Gene Expression Regulation * Kidney * Male * Rats * Rats, Sprague-Dawley * Snail Family Transcription Factors * Transcription Factors |keywords=* Diabetic nephropathy * Renal fibrosis * SRF * Snail |full-text-url=https://sci-hub.do/10.1016/j.acthis.2019.151460 }} {{medline-entry |title=Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31638828 |mesh-terms=* Actins * Adaptor Proteins, Signal Transducing * Aging * Biomechanical Phenomena * Cells, Cultured * Cytoskeleton * Gene Expression Regulation * Humans * Hydrogels * Intervertebral Disc Degeneration * Nucleus Pulposus * RNA Interference * Trans-Activators * Transcription Factors * rho-Associated Kinases |keywords=* F-actin * SRF * TEAD * intervertebral disc * mechanotransduction |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894097 }} ==SRL== {{medline-entry |title=Income dividends and subjective survival in a Cherokee Indian cohort: a quasi-experiment. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32432936 |mesh-terms=* Adult * Aged * Aged, 80 and over * Cohort Studies * Female * Humans * Income * Indians, South American * Longevity * Male * Middle Aged * North Carolina * Social Class * Surveys and Questionnaires * Survival Analysis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250001 }} ==SRM== {{medline-entry |title=[Geriatric specificities of localized renal cell carcinoma]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31771769 |mesh-terms=* Age Factors * Aged * Carcinoma, Renal Cell * Geriatric Assessment * Humans * Kidney Neoplasms |keywords=* Cancer du rein * Diagnosis * Diagnostic * Elderly * Geriatrics * Gériatrie * Personne âgée * Petite masse rénale * Renal cell carcinoma * Small renal mass * Traitement * Treatment |full-text-url=https://sci-hub.do/10.1016/j.purol.2019.08.281 }} ==SSB== {{medline-entry |title=Modelling the Effects of Beverage Substitution during Adolescence on Later Obesity Outcomes in Early Adulthood: Results from the Raine Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31816850 |mesh-terms=* Adolescent * Adolescent Nutritional Physiological Phenomena * Aging * Humans * Models, Biological * Obesity * Odds Ratio * Risk Factors * Sugar-Sweetened Beverages * Young Adult |keywords=* obesity * substitution modelling * sugar-sweetened beverages * waist circumference |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950484 }} ==SST== {{medline-entry |title=The distance to death perceptions of older adults explain why they age in place: A theoretical examination. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32972627 |keywords=* Agency- or belonging-related * Distance to death, aging in place * Emotions * Residential mobility * Socioemotional selectivity theory |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489887 }} {{medline-entry |title=Population Segmentation Based on Healthcare Needs: Validation of a Brief Clinician-Administered Tool. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32607929 |keywords=* aging * health services research * psychometrics |full-text-url=https://sci-hub.do/10.1007/s11606-020-05962-4 }} {{medline-entry |title=Examination on how emotion regulation mediates the relationship between future time perspective and well-being: a counter-evidence to the socioemotional selectivity theory. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32158369 |keywords=* Aging * Emotion regulation * Future time perspective * Socioemotional selectivity theory * Time left in life |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040126 }} ==STAT1== {{medline-entry |title=[[STAT1]]-p53-p21axis-dependent stress-induced progression of chronic nephrosis in adriamycin-induced mouse model. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32953802 |keywords=* Adriamycin * STAT1 * chronic nephrosis (CN) * mitogen-activated protein kinase * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7475511 }} {{medline-entry |title=Age-Dependent and -Independent Effects of Perivascular Adipose Tissue and Its Paracrine Activities during Neointima Formation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31906225 |mesh-terms=* Adipose Tissue * Aging * Animals * Carotid Arteries * Carotid Artery Diseases * Carotid Artery Injuries * Humans * Mice * Mice, Mutant Strains * Neointima * Paracrine Communication * STAT1 Transcription Factor |keywords=* aging * atherosclerosis * neointima formation * perivascular adipose tissue |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981748 }} {{medline-entry |title=Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/[[STAT1]] activation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31857155 |mesh-terms=* Animals * Bone Marrow Transplantation * Breast Neoplasms * Cell Cycle Proteins * Cell Line, Tumor * Cellular Senescence * Disease Models, Animal * Female * Gene Expression Regulation, Neoplastic * Humans * Integrin alphaVbeta3 * Interleukin-1beta * Janus Kinase 1 * Macrophage Activation * Macrophages * Mice * Mice, Knockout * STAT1 Transcription Factor * Signal Transduction |keywords=* Cellular senescence * Legumain * M1 polarization * Tumor-associated macrophage |full-text-url=https://sci-hub.do/10.1016/j.canlet.2019.12.013 }} ==STAT3== {{medline-entry |title=Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33083279 |keywords=* Cyclin D1 * NF-κB * STAT3 * Senescence * p62/SQSTM1 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548900 }} {{medline-entry |title=Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33045434 |keywords=* Aging * Appetite * Glucocorticoid * Leptin * Obesity * Osteoblast * Osteocyte |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596342 }} {{medline-entry |title=AMPK alleviates oxidative stress‑induced premature senescence via inhibition of NF-κB/[[STAT3]] axis-mediated positive feedback loop. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32882228 |keywords=* AMPK * NF-κB/STAT3 signalling * Oxidative stress * SASP * Senescence |full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111347 }} {{medline-entry |title=Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through [[STAT3]] activation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32848054 |mesh-terms=* Aging * Animals * Cell Differentiation * Cell Proliferation * Computational Biology * Gene Expression Regulation * Glucosamine * Hippocampus * Mice * Neural Stem Cells * Neurogenesis * Neuroglia * STAT3 Transcription Factor * Sequence Analysis, RNA |keywords=* O-GlcNAcylation * aging * gliogenesis * neural stem cells * neurogenesis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486730 }} {{medline-entry |title=Cell Death by Gallotannin Is Associated with Inhibition of the JAK/STAT Pathway in Human Colon Cancer Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32714471 |keywords=* Apoptosis * JAK/STAT * caspase * colon cancer * gallotannin * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378856 }} {{medline-entry |title=The effect of interleukin 6 deficiency on myocardial signal transduction pathways activation induced by bacterial lipopolysaccharide in young and old mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32693349 |keywords=* Aging * For review: bacterial lipolisacharide (LPS) * Heart * Inflammation * Interleukin-6 * Signal transduction |full-text-url=https://sci-hub.do/10.1016/j.advms.2020.06.006 }} {{medline-entry |title=Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 Patients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32517353 |keywords=* IL-6 * JAK * coronavirus * cytokine storm * remdesivir * senescence * stat3 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356916 }} {{medline-entry |title=Implication of JAK1/[[STAT3]]/SOCS3 Pathway in Aging of Cerebellum of Male Rat: Histological and Molecular study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32483368 |mesh-terms=* Aging * Animals * Caspase 3 * Cerebellum * Glial Fibrillary Acidic Protein * Glutathione * Immunohistochemistry * Janus Kinase 1 * Male * Malondialdehyde * Microscopy, Electron * Rats * Rats, Wistar * STAT3 Transcription Factor * Signal Transduction * Suppressor of Cytokine Signaling 3 Protein * Tumor Necrosis Factor-alpha |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264275 }} {{medline-entry |title=Atorvastatin-induced senescence of hepatocellular carcinoma is mediated by downregulation of hTERT through the suppression of the IL-6/[[STAT3]] pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32257389 |keywords=* Cancer therapy * Senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105491 }} {{medline-entry |title=Deciphering the Molecular Mechanism of Spontaneous Senescence in Primary Epithelial Ovarian Cancer Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32012719 |keywords=* aging biomarkers * cancer biology * cellular senescence * epithelial ovarian cancer * oxidative stress |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072138 }} {{medline-entry |title=Persistent Activation of [[STAT3]] Pathway in the Retina Induced Vision Impairment and Retinal Degenerative Changes in Ageing Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31884637 |mesh-terms=* Aging * Animals * Mice * Mice, Inbred C57BL * Retina * Retinal Degeneration * STAT3 Transcription Factor * Suppressor of Cytokine Signaling 3 Protein * Suppressor of Cytokine Signaling Proteins * Uveitis |keywords=* EAU * Experimental autoimmune uveitis * Retinal dystrophies * SOCS3 * STAT3 * Transgenic mouse * Uveitis |full-text-url=https://sci-hub.do/10.1007/978-3-030-27378-1_58 }} {{medline-entry |title=Interleukin-10 induces senescence of activated hepatic stellate cells via [[STAT3]]-p53 pathway to attenuate liver fibrosis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31730896 |keywords=* Hepatic stellate cells * Interleukin-10 * Liver fibrosis * Senescence * Signal pathway |full-text-url=https://sci-hub.do/10.1016/j.cellsig.2019.109445 }} ==STC2== {{medline-entry |title=Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and [[STC2]]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31761296 |mesh-terms=* Adult * Aged * Aging * Animals * Body Composition * Body Weight * Calcium-Binding Proteins * Case-Control Studies * Female * Follow-Up Studies * Genome-Wide Association Study * Glycoproteins * Humans * Intercellular Signaling Peptides and Proteins * Male * Mice * Middle Aged * Muscle Development * Muscle, Skeletal * Quantitative Trait Loci * Thinness |keywords=* UK Biobank * human and mouse GWAS * sarcopenia * skeletal muscle |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904802 }} ==STIM1== {{medline-entry |title=Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31833196 |mesh-terms=* Animals * Calcium * Calnexin * Cell Nucleus * Disease Models, Animal * Endoplasmic Reticulum * Endoplasmic Reticulum Stress * Lamin Type A * Mice * Mice, Knockout * Microscopy, Electron, Transmission * Muscle Proteins * Muscle, Skeletal * Muscular Dystrophies * Mutation * Myoblasts * ORAI1 Protein * Progeria * Proteolipids * Stromal Interaction Molecule 1 * Thermogenesis * Up-Regulation |keywords=* aging * calcium homeostasis * lamin A * muscular dystrophy * progeria |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996945 }} ==STS== {{medline-entry |title=Delayed Impairment of Postural, Physical, and Muscular Functions Following Downhill Compared to Level Walking in Older People. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33192547 |keywords=* aging * balance * falls * fatigue * functional performance * muscle damage * walking |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7609421 }} {{medline-entry |title=Autophagy displays divergent roles during intermittent amino acid starvation and toxic stress-induced senescence in cultured skeletal muscle cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33022071 |keywords=* autophagy * caspase * cell death * remodeling * senescence |full-text-url=https://sci-hub.do/10.1002/jcp.30079 }} {{medline-entry |title=The WRKY53 transcription factor enhances stilbene synthesis and disease resistance by interacting with MYB14 and MYB15 in Chinese wild grape. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32080737 |keywords=* Chinese wild grape (Vitis quinquangularis) * WRKY transcription factor * disease resistance * leaf senescence * stilbene * transcriptional regulation |full-text-url=https://sci-hub.do/10.1093/jxb/eraa097 }} {{medline-entry |title=On the role of ageing and musculoskeletal pain on dynamic balance in manual workers. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31733466 |mesh-terms=* Aged * Aging * Female * Humans * Male * Middle Aged * Muscle, Skeletal * Musculoskeletal Pain * Occupational Diseases * Postural Balance |keywords=* Discomfort * Lower extremity function * Posturography * Sit-to-stand |full-text-url=https://sci-hub.do/10.1016/j.jelekin.2019.102374 }} ==SUCNR1== {{medline-entry |title=[The effect of Mexidol on cerebral mitochondriogenesis at a young age and during aging]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32105271 |mesh-terms=* Age Factors * Aging * Animals * Male * Mitochondria * Neurodegenerative Diseases * Picolines * Rats * Receptors, G-Protein-Coupled * Transcription Factors |keywords=* Western blot analysis * aging * cerebral mitochondriogenesis * mexidol * mitochondrial dysfunction * rats * respiratory enzyme subunits * succinate receptor * transcriptional coactivator PGC-1α |full-text-url=https://sci-hub.do/10.17116/jnevro202012001162 }} ==SUGCT== {{medline-entry |title=Knockout of the non-essential gene [[SUGCT]] creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31722069 |mesh-terms=* Aging * Animals * Anti-Bacterial Agents * Bacteria * Carnitine * Coenzyme A-Transferases * Dietary Supplements * Feces * Gastrointestinal Microbiome * Humans * Kidney * Lipid Metabolism * Liver * Lysine * Metabolic Syndrome * Metabolome * Mice * Mice, Knockout * Obesity * Tryptophan |keywords=* C7orf10 * Glutaric aciduria type 3 (GA3) * Gut microflora * Lipids * Metabolomics * Obesity * Sugct |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426296 }} ==SUV39H1== {{medline-entry |title=Increase in hippocampal histone H3K9me3 is negatively correlated with memory in old male mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31760560 |keywords=* Aging * H3K9me3 * Hippocampus * IEGs * Memory * SUV39H1 |full-text-url=https://sci-hub.do/10.1007/s10522-019-09850-1 }} ==SYK== {{medline-entry |title=miR-25-3p promotes endothelial cell angiogenesis in aging mice via TULA-2/[[SYK]]/VEGFR-2 downregulation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33201836 |keywords=* TULA-2 * aging * angiogenesis * endothelial cell * miR-25-3p |full-text-url=https://sci-hub.do/10.18632/aging.103834 }} {{medline-entry |title=Identification of [[SYK]] inhibitor, R406 as a novel senolytic agent. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32379705 |keywords=* FAK * apoptosis * cellular senescence * p38 * senolytics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244031 }} ==SYNE1== {{medline-entry |title=Nesprin-1 impact on tumorigenic cell phenotypes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31741263 |mesh-terms=* Actins * Carcinogenesis * Cell Line, Tumor * Cell Nucleus * Cytoskeletal Proteins * Gene Expression * Gene Expression Regulation, Neoplastic * Humans * Microfilament Proteins * Nerve Tissue Proteins * Nuclear Envelope * Phenotype |keywords=* Cancer * Cellular senescence * Genome stability * Nesprin-1 * Nuclear envelope |full-text-url=https://sci-hub.do/10.1007/s11033-019-05184-w }} ==TAAR1== {{medline-entry |title=Minimal Age-Related Alterations in Behavioral and Hematological Parameters in Trace Amine-Associated Receptor 1 ([[TAAR1]]) Knockout Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31399838 |mesh-terms=* Age Factors * Animals * Anxiety * Dose-Response Relationship, Drug * Male * Mice * Mice, 129 Strain * Mice, Inbred C57BL * Mice, Knockout * Receptors, G-Protein-Coupled * Sodium Chloride |keywords=* Aging * Anxiety * Hematology * Leukocytes * Neutrophils * TAAR1 * Thyroid * Trace amines |full-text-url=https://sci-hub.do/10.1007/s10571-019-00721-4 }} ==TAS2R16== {{medline-entry |title=Taste receptor polymorphisms and longevity: a systematic review and meta-analysis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33170488 |keywords=* Immune-inflammatory responses * Longevity * Meta-analysis * Taste receptors |full-text-url=https://sci-hub.do/10.1007/s40520-020-01745-3 }} ==TAS2R38== {{medline-entry |title=[[TAS2R38]] bitter taste receptor and attainment of exceptional longevity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31792278 |mesh-terms=* Adolescent * Adult * Aged * Aged, 80 and over * Case-Control Studies * Female * Food Preferences * Gene Frequency * Genetic Variation * Haplotypes * Humans * Longevity * Male * Middle Aged * Receptors, G-Protein-Coupled * Taste * Taste Perception * Young Adult |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889489 }} ==TAZ== {{medline-entry |title=Transcriptional Coactivator [[TAZ]] Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31936650 |keywords=* TAZ * cellular senescence * oncogene * p300 * p53 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016652 }} ==TBC1D5== {{medline-entry |title=[[TBC1D5]]-Catalyzed Cycling of Rab7 Is Required for Retromer-Mediated Human Papillomavirus Trafficking during Virus Entry. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32521275 |keywords=* HPV * Rab7B * TBC1D5 * functional genetics screen * proximity ligation assay * retrograde * retromer * senescence * traptamer |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339955 }} {{medline-entry |title=Retromer and [[TBC1D5]] maintain late endosomal RAB7 domains to enable amino acid-induced mTORC1 signaling. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31431476 |mesh-terms=* Animals * Caenorhabditis elegans * Caenorhabditis elegans Proteins * Longevity * Mechanistic Target of Rapamycin Complex 1 * Membrane Microdomains * Signal Transduction * rab GTP-Binding Proteins |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719456 }} ==TBK1== {{medline-entry |title=Parkin overexpression alleviates cardiac aging through facilitating K63-polyubiquitination of [[TBK1]] to facilitate mitophagy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33164878 |keywords=* Aging * K63-linked polyubiquitination * Mitophagy * Parkin * TBK1 |full-text-url=https://sci-hub.do/10.1016/j.bbadis.2020.165997 }} ==TCF7L2== {{medline-entry |title=A myelin-related transcriptomic profile is shared by Pitt-Hopkins syndrome models and human autism spectrum disorder. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32015540 |mesh-terms=* Aging * Animals * Autism Spectrum Disorder * Cell Count * DNA Fingerprinting * Facies * Gene Expression Regulation * Humans * Hyperventilation * Intellectual Disability * Methyl-CpG-Binding Protein 2 * Mice * Mice, Knockout * Myelin Sheath * Oligodendroglia * PTEN Phosphohydrolase * Primary Cell Culture * Signal Transduction * Transcription Factor 4 * Transcriptome |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065955 }} ==TEC== {{medline-entry |title=Vestibular function and cortical and sub-cortical alterations in an aging population. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32904672 |keywords=* Aging * Cognition * Diffeomorphometry * Epidemiology * Eye-ear-nose-throat * MRI * Medical imaging * Shape * Vestibular * Volume |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457317 }} {{medline-entry |title=Metabolic Flexibility and Innate Immunity in Renal Ischemia Reperfusion Injury: The Fine Balance Between Adaptive Repair and Tissue Degeneration. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32733450 |keywords=* cell death * innate immunity * kidney transplantation * mitochondria * senescence * tubular repair |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358591 }} {{medline-entry |title=Postnatal Involution and Counter-Involution of the Thymus. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32477366 |keywords=* Myc * aging * cyclin D1 * growth * involution * thymus |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235445 }} {{medline-entry |title=Gender Disparity Impacts on Thymus Aging and LHRH Receptor Antagonist-Induced Thymic Reconstitution Following Chemotherapeutic Damage. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32194555 |keywords=* aging * chemotherapy * gender * luteinizing hormone-releasing hormone * regeneration * sex hormone deprivation * thymic epithelial cell * thymus |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062683 }} {{medline-entry |title=Clonogenic Culture of Mouse Thymic Epithelial Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31396938 |mesh-terms=* Aging * Animals * Cell Differentiation * Cell Line * Coculture Techniques * Colony-Forming Units Assay * DNA-Binding Proteins * Epithelial Cells * Flow Cytometry * Fluorescent Antibody Technique, Direct * Fluorescent Dyes * Immunomagnetic Separation * Mice * Mice, Knockout * Primary Cell Culture * Rhodamines * Self Tolerance * Staining and Labeling * Stem Cells * Thymus Gland |keywords=* Clonogenic assay * Thymic epithelial cells * Thymic epithelial stem cells * Thymus |full-text-url=https://sci-hub.do/10.1007/978-1-4939-9728-2_15 }} ==TEF== {{medline-entry |title=Expression of human HSP27 in yeast extends replicative lifespan and uncovers a hormetic response. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32189112 |keywords=* Aging * Cancer * HSP27 * Hormesis * Neurodegeneratve diseases * Proteasome |full-text-url=https://sci-hub.do/10.1007/s10522-020-09869-9 }} ==TERT== {{medline-entry |title=Telomeres and telomerase in risk assessment of cardiovascular diseases. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33171154 |keywords=* Cardiovascular diseases * Senescence * Telomerase * Telomeres |full-text-url=https://sci-hub.do/10.1016/j.yexcr.2020.112361 }} {{medline-entry |title=A 4-Base-Pair Core-Enclosing Helix in Telomerase RNA Is Essential for Activity and for Binding to the Telomerase Reverse Transcriptase Catalytic Protein Subunit. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33046533 |keywords=* RNA * RNP * TERT * TLC1 * senescence * telomerase * telomerase RNA * telomere * two-hybrid screening * yeast |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685517 }} {{medline-entry |title=Angiotensin inhibition and cellular senescence in the developing rat kidney. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33010296 |keywords=* Apoptosis * Cellular senescence * Fetal development * Kidney * Renin-angiotensin system |full-text-url=https://sci-hub.do/10.1016/j.yexmp.2020.104551 }} {{medline-entry |title=Decreased expression of [[TERT]] and telomeric proteins as human ovaries age may cause telomere shortening. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32856217 |keywords=* Ovarian aging * TERT * Telomere * Telomere-binding proteins |full-text-url=https://sci-hub.do/10.1007/s10815-020-01932-1 }} {{medline-entry |title=The secrets of telomerase: Retrospective analysis and future prospects. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32698073 |mesh-terms=* Aging * Animals * Diabetes Mellitus * Humans * Neoplasms * Telomerase * Telomere Shortening |keywords=* Cancers * G-quadruplex formation * Metabolic disorders * TERT gene * Telomere-telomerase system |full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118115 }} {{medline-entry |title=Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32399807 |keywords=* Cell aging * Genes * Human mesenchymal stem cells * Short peptides |full-text-url=https://sci-hub.do/10.1007/s11033-020-05506-3 }} {{medline-entry |title=Unravelling Cellular Mechanisms of Stem Cell Senescence: An Aid from Natural Bioactive Molecules. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32244882 |keywords=* cellular mechanisms * gene expression * nutraceuticals * oxidative stress * senescence * stem cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150900 }} {{medline-entry |title=Expression of telomerase reverse transcriptase positively correlates with duration of lithium treatment in bipolar disorder. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32114208 |mesh-terms=* Adult * Aging * Antimanic Agents * Bipolar Disorder * Cellular Senescence * Female * Humans * Lithium * Lithium Compounds * Male * Middle Aged * Mitochondria * Oxidative Stress * Polymorphism, Single Nucleotide * Real-Time Polymerase Chain Reaction * Telomerase * Telomere * Telomere Homeostasis * Telomere Shortening |keywords=* Affective disorder * Aging * Mitochondria * Oxidative stress * TERT * Telomere |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334059 }} {{medline-entry |title=FAM96B inhibits the senescence of dental pulp stem cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32039527 |keywords=* FAM96B * aging * dental pulp stem cells (DPSCs) * proteomic analysis |full-text-url=https://sci-hub.do/10.1002/cbin.11319 }} {{medline-entry |title=Aging and biomarkers: Transcriptional levels evaluation of Osteopontin/miRNA-181a axis in hepatic tissue of rats in different age ranges. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32061643 |keywords=* Aging * Long non-coding RNA * Osteopontin * Telomeres * miRNA |full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110879 }} {{medline-entry |title=Resveratrol inhibits adipocyte differentiation and cellular senescence of human bone marrow stromal stem cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31978617 |keywords=* Adipogenesis * Antioxidant * Bone marrow adiposity * Bone marrow skeletal stromal cells * Cellular senescence * Osteogenesis |full-text-url=https://sci-hub.do/10.1016/j.bone.2020.115252 }} {{medline-entry |title=Characterization of human telomerase reverse transcriptase immortalized anterior cruciate ligament cell lines. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31948601 |mesh-terms=* Adolescent * Aged * Anterior Cruciate Ligament * Cell Differentiation * Cell Separation * Cells, Cultured * Humans * Mesenchymal Stem Cells * Telomerase |keywords=* Anterior cruciate ligament * Immortalization * Mesenchymal stem cells * Multilineage differentiation * Senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962762 }} {{medline-entry |title=Mitochondria, Telomeres and Telomerase Subunits. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31781563 |keywords=* TERC * TERT * aging * mitochondria * telomerase * telomere |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851022 }} {{medline-entry |title=Towards Therapeutic Alternatives for Mercury Neurotoxicity in the Amazon: Unraveling the Pre-Clinical Effects of the Superfruit Açaí ([i]Euterpe oleracea[/i], Mart.) as Juice for Human Consumption. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31717801 |mesh-terms=* Animals * Antioxidants * Behavior, Animal * Brain Chemistry * Euterpe * Fruit and Vegetable Juices * Lipid Peroxidation * Male * Mercury * Mice * Motor Skills * Neurotoxins * Plant Extracts * Telomere |keywords=* Euterpe * acai * aging * antioxidant * açaí * extract * intoxication * methylmercury * telomere |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893510 }} {{medline-entry |title=Replication Stress at Telomeric and Mitochondrial DNA: Common Origins and Consequences on Ageing. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31597307 |mesh-terms=* Aging * Animals * Cellular Senescence * DNA Damage * DNA Replication * DNA, Mitochondrial * Epigenesis, Genetic * Humans * Mitochondria * Oxidative Stress * Stress, Physiological * Telomere * Telomere Homeostasis * Telomere Shortening |keywords=* G-quadruplex * R-loop * ageing * helicase * mitochondria * replication stress * senescence * telomere |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801922 }} {{medline-entry |title=Telomerase Biology Associations Offer Keys to Cancer and Aging Therapeutics. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31544708 |keywords=* Aging * TERT * associates * cancer * cell cycle * diseases * oncogenes * viral infection. |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403649 }} {{medline-entry |title=Transient induction of telomerase expression mediates senescence and reduces tumorigenesis in primary fibroblasts. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31481614 |mesh-terms=* Animals * Cell Cycle * Cell Transformation, Neoplastic * Cells, Cultured * Cellular Senescence * Fibroblasts * Gene Expression * Gene Expression Regulation * Gene Knockdown Techniques * Humans * Mice * Mice, Inbred C57BL * Mice, Knockout * Phenotype * Telomerase * Telomere |keywords=* ATM * senescence * telomerase * tumorigenesis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754593 }} ==TET2== {{medline-entry |title=Non-coding and Loss-of-Function Coding Variants in [[TET2]] are Associated with Multiple Neurodegenerative Diseases. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32330418 |mesh-terms=* Aged * Aged, 80 and over * Alzheimer Disease * Animals * Cognition * DNA-Binding Proteins * Female * Frontotemporal Dementia * Humans * Loss of Function Mutation * Male * Mice * Neurodegenerative Diseases * Proto-Oncogene Proteins |keywords=* AD * ALS * Alzheimer * FTD * TET2 * aging * amyotrophic lateral sclerosis * frontotemporal dementia * genome sequencing * non-coding |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212268 }} {{medline-entry |title=60 Years of clonal hematopoiesis research: From X-chromosome inactivation studies to the identification of driver mutations. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32001340 |mesh-terms=* Adult * Aging * Biomedical Research * Chromosomes, Human, X * DNA-Binding Proteins * Female * Hematopoiesis * Hematopoietic Stem Cells * History, 20th Century * History, 21st Century * Humans * Male * Mutation * Proto-Oncogene Proteins * Receptors, Androgen * Repressor Proteins * X Chromosome Inactivation |full-text-url=https://sci-hub.do/10.1016/j.exphem.2020.01.008 }} {{medline-entry |title=DNA methylation instability by BRAF-mediated TET silencing and lifestyle-exposure divides colon cancer pathways. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31842975 |mesh-terms=* Animals * Caco-2 Cells * Cell Line, Tumor * Colonic Neoplasms * DNA Methylation * DNA-Binding Proteins * Down-Regulation * Epigenesis, Genetic * Female * Gene Regulatory Networks * HT29 Cells * Humans * Male * Mice * Mixed Function Oxygenases * Mutation * Neoplasms, Experimental * Proto-Oncogene Proteins * Proto-Oncogene Proteins B-raf |keywords=* Aging * BRAF V600E * CIMP * Colon cancer * DNA methylation * TET |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916434 }} {{medline-entry |title=Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31406340 |mesh-terms=* Adult * Age Factors * Aged * Aged, 80 and over * Aging * Animals * Cardiovascular Diseases * DNA (Cytosine-5-)-Methyltransferases * DNA-Binding Proteins * Genetic Predisposition to Disease * Hematopoiesis * Hematopoietic Stem Cells * Humans * Inflammation * Middle Aged * Mutation * Phenotype * Proto-Oncogene Proteins * Repressor Proteins * Risk Assessment * Risk Factors |full-text-url=https://sci-hub.do/10.1038/s41569-019-0247-5 }} ==TF== {{medline-entry |title=A preliminary investigation of the contribution of different tenderness factors to beef loin, tri-tip and heel tenderness. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32736289 |keywords=* Aging * Beef * Collagen * Tenderness * Trained panel |full-text-url=https://sci-hub.do/10.1016/j.meatsci.2020.108247 }} {{medline-entry |title=The transcription factor ZmNAC126 accelerates leaf senescence downstream of the ethylene signalling pathway in maize. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32430911 |keywords=* ZmNAC * chlorophyll catabolic genes * ethylene * leaf senescence * maize |full-text-url=https://sci-hub.do/10.1111/pce.13803 }} {{medline-entry |title=Extensive transcriptome changes during seasonal leaf senescence in field-grown black cottonwood (Populus trichocarpa Nisqually-1). |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32313054 |mesh-terms=* Aging * Gene Expression Profiling * Gene Expression Regulation, Plant * Genome, Plant * Photosynthesis * Plant Leaves * Populus * Seasons * Transcription Factors * Transcriptome |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170949 }} {{medline-entry |title=Expression of Transferrin and Albumin in the Sperm-Storage Tubules of Japanese Quail and their Possible Involvement in Long-Term Sperm Storage. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32174770 |keywords=* Japanese quail * albumin * sperm longevity * sperm storage tubules * transferrin |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063080 }} {{medline-entry |title=OsWRKY5 Promotes Rice Leaf Senescence via Senescence-Associated NAC and Abscisic Acid Biosynthesis Pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31505875 |mesh-terms=* Abscisic Acid * Chlorophyll * Gene Expression Regulation, Plant * Gene Knockdown Techniques * Oryza * Plant Leaves * Plant Proteins * Transcription Factors |keywords=* NAC * OsWRKY * abscisic acid (ABA) * leaf senescence * rice |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770167 }} {{medline-entry |title=BrTCP7 Transcription Factor Is Associated with MeJA-Promoted Leaf Senescence by Activating the Expression of [i]BrOPR3[/i] and [i]BrRCCR[/i]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31416297 |mesh-terms=* Amino Acid Sequence * Brassica * Cellular Senescence * Cyclopentanes * Gene Expression Regulation, Plant * Oxylipins * Phenotype * Phylogeny * Plant Growth Regulators * Plant Leaves * Plant Proteins * Promoter Regions, Genetic * Protein Binding * Transcription Factors |keywords=* Chinese flowering cabbage * JA * leaf senescence * transcriptional activation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719003 }} {{medline-entry |title=Activation of the Transcription of [i]BrGA20ox3[/i] by a BrTCP21 Transcription Factor Is Associated with Gibberellin-Delayed Leaf Senescence in Chinese Flowering Cabbage during Storage. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31398806 |mesh-terms=* Aging * Base Sequence * Brassica * Food Preservation * Gene Expression Regulation, Plant * Gibberellins * Phenotype * Phylogeny * Plant Leaves * Plant Proteins * Promoter Regions, Genetic * Protein Binding * Transcription Factors |keywords=* Chinese flowering cabbage * GA * leaf senescence * transcriptional activation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720506 }} ==TFEB== {{medline-entry |title=A Novel Lipofuscin-detecting Marker of Senescence Relates With Hypoxia, Dysregulated Autophagy and With Poor Prognosis in Non-small-cell-lung Cancer. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33144423 |keywords=* Senescence * autophagy * glycolysis * hypoxia * lipofuscin * lung cancer |full-text-url=https://sci-hub.do/10.21873/invivo.12154 }} {{medline-entry |title=ESC-sEVs Rejuvenate Senescent Hippocampal NSCs by Activating Lysosomes to Improve Cognitive Dysfunction in Vascular Dementia. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32440476 |keywords=* embryonic stem cells derived small extracellular vesicles (ESC‐sEVs) * hippocampal neural stem cells (HNSCs) * lysosomes * senescence * vascular dementia |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237844 }} {{medline-entry |title=Nitrative Stress-Related Autophagic Insufficiency Participates in Hyperhomocysteinemia-Induced Renal Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32047576 |mesh-terms=* Aging * Animals * Autophagy * Cells, Cultured * Homocysteine * Humans * Hyperhomocysteinemia * Kidney * Kidney Diseases * Male * Metalloporphyrins * Peroxynitrous Acid * Rats * Rats, Sprague-Dawley |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007752 }} {{medline-entry |title=Polyamines reverse immune senescence via the translational control of autophagy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31679458 |mesh-terms=* Aging * Animals * Autophagy * Humans * Lysosomes * Polyamines * Protein Processing, Post-Translational * Spermidine |keywords=* Aging * B cells * EIF5A * TFEB * autophagy * hypusine * spermidine * translation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984486 }} {{medline-entry |title=Polyamines Control eIF5A Hypusination, [[TFEB]] Translation, and Autophagy to Reverse B Cell Senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31474573 |mesh-terms=* Adaptive Immunity * Age Factors * Aging * Animals * Autophagy * B-Lymphocytes * Basic Helix-Loop-Helix Leucine Zipper Transcription Factors * Cellular Senescence * HEK293 Cells * Humans * Immunologic Memory * Immunosenescence * Jurkat Cells * Mice * Mice, Inbred C57BL * Mice, Knockout * NIH 3T3 Cells * Peptide Initiation Factors * Protein Processing, Post-Translational * RNA-Binding Proteins * Signal Transduction * Spermidine |keywords=* B cell * TFEB * aging * autophagy * eIF5A * spermidine |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863385 }} ==TFPI== {{medline-entry |title=Identification of cardiovascular health gene variants related to longevity in a Chinese population. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32897244 |keywords=* Chinese * factor related to cardiovascular health (FCH) * genetic variation * lipid metabolism * longevity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521493 }} ==TG== {{medline-entry |title=Inhibition of the alternative lengthening of telomeres pathway by subtelomeric sequences in Saccharomyces cerevisiae. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33126043 |keywords=* Budding yeast * Rad52 * Replicative senescence * Subtelomeric Y’ elements * Telomerase-independent telomere maintenance * Telomere recombination |full-text-url=https://sci-hub.do/10.1016/j.dnarep.2020.102996 }} {{medline-entry |title=E4orf1, an Adeno-viral protein, attenuates renal lipid accumulation in high fat fed mice: A novel approach to reduce a key risk factor for chronic kidney disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33102865 |keywords=* Aging * CKD * Diabetes * Diet * E4orf1 * FA synthesis * Hyperinsulinemia * Insulin * Lipid metabolism * Obesity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575883 }} {{medline-entry |title=Resistance exercise attenuates postprandial metabolic responses to a high-fat meal similarly in younger and older men. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33032071 |keywords=* Aging * Cardiometabolic * Lipemia * Metabolism * Nutrition |full-text-url=https://sci-hub.do/10.1016/j.nutres.2020.08.012 }} {{medline-entry |title=Aging-induced aberrant RAGE/PPARα axis promotes hepatic steatosis via dysfunctional mitochondrial β oxidation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32936538 |keywords=* PPARα * RAGE * aging * hepatic steatosis * mitochondria |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576254 }} {{medline-entry |title=Fenofibrate impairs liver function and structure more pronounced in old than young rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32927318 |keywords=* Aging * Fenofibrate * Lipids * Liver function and morphology * Rat * serum |full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104244 }} {{medline-entry |title=Awareness of major cardiovascular risk factors and its relationship with markers of vascular aging: Data from the Brisighella Heart Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32249143 |mesh-terms=* Adolescent * Adult * Age Factors * Aged * Aged, 80 and over * Aging * Biomarkers * Blood Glucose * Blood Pressure * Cardiovascular Diseases * Cholesterol * Cross-Sectional Studies * Diabetes Mellitus * Female * Humans * Hypercholesterolemia * Hypertension * Hypertriglyceridemia * Italy * Male * Middle Aged * Risk Assessment * Risk Factors * Triglycerides * Vascular Stiffness * Young Adult |keywords=* Arterial aging * Awareness * Epidemiology * Pulse wave velocity * Risk factors |full-text-url=https://sci-hub.do/10.1016/j.numecd.2020.03.005 }} {{medline-entry |title=Characterisation of the dynamic nature of lipids throughout the lifespan of genetically identical female and male Daphnia magna. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32221338 |mesh-terms=* Aging * Animals * Daphnia * Diglycerides * Female * Lipid Metabolism * Longevity * Male * Phosphatidylcholines * Sphingomyelins * Triglycerides |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101400 }} {{medline-entry |title=Effects of laboratory biotic aging on the characteristics of biochar and its water-soluble organic products. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31472466 |mesh-terms=* Benzopyrans * Charcoal * Humic Substances * Microbiota * Soil Microbiology * Solubility * Triticum * Water |keywords=* Biochar * Biotic incubation aging * Dissolved organic matter (DOM) * Excitation-emission matrix * Humification |full-text-url=https://sci-hub.do/10.1016/j.jhazmat.2019.121071 }} {{medline-entry |title=Using Caenorhabditis elegans for Studying Trans- and Multi-Generational Effects of Toxicants. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31403614 |mesh-terms=* Animals * Caenorhabditis elegans * Hazardous Substances * Humans * Longevity * Reproduction * Toxicity Tests |full-text-url=https://sci-hub.do/10.3791/59367 }} ==TH== {{medline-entry |title=Thyroid hormone signaling is associated with physical performance, muscle mass, and strength in a cohort of oldest-old: results from the Mugello study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33219914 |keywords=* Aging * Muscle mass * Muscle strength * Oldest-old * Physical performance * Rehabilitation * Thyroid hormone signaling |full-text-url=https://sci-hub.do/10.1007/s11357-020-00302-0 }} {{medline-entry |title=Social Environment Ameliorates Behavioral and Immune Impairments in Tyrosine Hydroxylase Haploinsufficient Female Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32772235 |keywords=* Behavioral responses * Immunosenescence * Oxidative-inflammatory stress * Social environmental strategy * Tyrosine hydroxylase haploinsufficient mice |full-text-url=https://sci-hub.do/10.1007/s11481-020-09947-2 }} {{medline-entry |title=Mechanism of thyroid hormone signaling in skeletal muscle of aging mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32720201 |keywords=* Aging * Mice * Skeletal muscle * Thyroid hormone signaling |full-text-url=https://sci-hub.do/10.1007/s12020-020-02428-9 }} {{medline-entry |title=Longitudinal changes in bone mineral density and trabecular bone score in Korean adults: a community-based prospective study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32621253 |mesh-terms=* Absorptiometry, Photon * Adult * Bone Density * Cancellous Bone * Cohort Studies * Female * Humans * Lumbar Vertebrae * Male * Prospective Studies * Republic of Korea |keywords=* Aging * Bone mineral density * Natural history * Osteoporosis |full-text-url=https://sci-hub.do/10.1007/s11657-020-00731-6 }} {{medline-entry |title=Quantitative proteomic profiling of the rat substantia nigra places glial fibrillary acidic protein at the hub of proteins dysregulated during aging: Implications for idiopathic Parkinson's disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32270889 |keywords=* RRID:AB_11145309 * RRID:AB_2109791 * RRID:AB_228307 * RRID:AB_228341 * RRID:AB_2336820 * RRID:AB_2631098 * RRID:AB_390204 * RRID:MGI:5651135 * RRID:SCR_001881 * RRID:SCR_002798 * RRID:SCR_003070 * RRID:SCR_004946 * RRID:SCR_005223 * aging * dopaminergic neuron * glial fibrillary acidic protein * proteome * proteomics * substantia nigra |full-text-url=https://sci-hub.do/10.1002/jnr.24622 }} {{medline-entry |title=Withaferin-A Protects the Nigral Dopamine Neuron and Recovers Motor Activity in Aged Rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31982873 |mesh-terms=* Aging * Animals * Brain * Corpus Striatum * Dopaminergic Neurons * Male * Motor Activity * Neuroprotective Agents * Rats * Rats, Wistar * Substantia Nigra * Tyrosine 3-Monooxygenase * Withanolides |keywords=* Ageing * Dopamine * Striatum * Substantia nigra * Withaferin-A |full-text-url=https://sci-hub.do/10.1159/000505183 }} {{medline-entry |title=Effects of physical activity on bone mineral density in older adults: Korea National Health and Nutrition Examination Survey, 2008-2011. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31655946 |mesh-terms=* Absorptiometry, Photon * Aged * Bone Density * Cross-Sectional Studies * Exercise * Female * Femur Neck * Humans * Lumbar Vertebrae * Male * Middle Aged * Nutrition Surveys * Osteoporosis * Republic of Korea * Surveys and Questionnaires |keywords=* Aging * Bone mineral density * Exercise * Gender * Osteoporosis * Physical activity |full-text-url=https://sci-hub.do/10.1007/s11657-019-0655-5 }} {{medline-entry |title=Age-Related Resistance to Thyroid Hormone Action. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31512083 |mesh-terms=* Aged * Aged, 80 and over * Aging * Animals * Humans * Hyperthyroidism * Hypothyroidism * Iodide Peroxidase * Male * Receptors, Thyroid Hormone * Thyroid Hormones * Thyroxine * Triiodothyronine |full-text-url=https://sci-hub.do/10.1007/s40266-019-00711-7 }} {{medline-entry |title=Age-Dependent Changes in Glucose Homeostasis in Male Deiodinase Type 2 Knockout Zebrafish. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31504428 |mesh-terms=* Aging * Animals * Animals, Genetically Modified * Glucose * Glucose Transport Proteins, Facilitative * Homeostasis * Hyperglycemia * Iodide Peroxidase * Islets of Langerhans * Male * Proglucagon * Proinsulin * Receptor, Insulin * Receptors, Glucagon * Zebrafish |full-text-url=https://sci-hub.do/10.1210/en.2019-00445 }} {{medline-entry |title=Age effect on thyroid hormone brain response in male mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31494803 |mesh-terms=* Aging * Animals * Brain * Gene Expression * Hyperthyroidism * Hypothyroidism * Male * Maze Learning * Mice, Inbred C57BL * Monocarboxylic Acid Transporters * Organic Cation Transport Proteins * Rotarod Performance Test * Symporters * Thyroid Hormones * Thyrotropin * Thyrotropin-Releasing Hormone |keywords=* Ageing * Hyperthyroidism * Hypothyroidism * Male mice * Thyroid hormones |full-text-url=https://sci-hub.do/10.1007/s12020-019-02078-6 }} {{medline-entry |title=Aging Is Associated with Low Thyroid State and Organ-Specific Sensitivity to Thyroxine. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31441387 |mesh-terms=* Aging * Animals * DNA-Binding Proteins * Hypothalamo-Hypophyseal System * Liver * Male * Mice * Mice, Inbred C57BL * Myocardium * Pituitary Gland * Thyroid Gland * Thyroid Hormones * Thyrotropin * Thyroxine * Transcription Factors |keywords=* HPT-axis * aging * mice * thyroid gland * thyroid hormones |full-text-url=https://sci-hub.do/10.1089/thy.2018.0377 }} ==TLR1== {{medline-entry |title=Effects of aging and lifelong aerobic exercise on expression of innate immune components in human skeletal muscle. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32969782 |keywords=* TLR * aging * innate immunity * lifelong exercise * skeletal muscle |full-text-url=https://sci-hub.do/10.1152/japplphysiol.00615.2020 }} {{medline-entry |title=Association of TLR gene variants in a Czech Red Pied cattle population with reproductive traits. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31901560 |mesh-terms=* Age Factors * Animals * Breeding * Cattle * Czech Republic * Female * Genotype * Longevity * Male * Phenotype * Polymorphism, Single Nucleotide * Reproduction * Toll-Like Receptor 1 * Toll-Like Receptor 2 * Toll-Like Receptor 6 * Toll-Like Receptors |keywords=* Cattle * Diversity * Effect prediction * Health traits * Toll-like receptors |full-text-url=https://sci-hub.do/10.1016/j.vetimm.2019.109997 }} ==TLR2== {{medline-entry |title=Changes in salivary microbial sensing proteins CD14 and [[TLR2]] with aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32529494 |mesh-terms=* Adolescent * Adult * Aging * Biomarkers * Child * Child, Preschool * Humans * Lipopolysaccharide Receptors * Middle Aged * Saliva * Salivary Proteins and Peptides * Toll-Like Receptor 2 * Young Adult |keywords=* Age changes * CD14 * Saliva * Toll-like receptor-2 |full-text-url=https://sci-hub.do/10.1007/s00784-020-03274-9 }} {{medline-entry |title=Culture Model for Non-human Primate Choroid Plexus. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31555096 |keywords=* aging * cell culture * choroid plexus * epithelial cell * infectious disease * rhesus macaque |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6724611 }} ==TLR4== {{medline-entry |title=Age-Dependent Changes of Adipokine and Cytokine Secretion From Rat Adipose Tissue by Endogenous and Exogenous Toll-Like Receptor Agonists. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32973755 |keywords=* adipokines * aging * batokines * biglycan * cytokines * fat explant cultures * high mobility group box-1 protein * lipopolysaccharide |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466552 }} {{medline-entry |title=Role of Toll Like Receptor 4 in Alzheimer's Disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32983082 |keywords=* Alzheimer’s disease * TLR4 * aging * amyloid beta oligomers * calcium * hippocampal neurons |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479089 }} {{medline-entry |title=Commentary on Some Recent Theses Relevant to Combating Aging: August 2020. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32718230 |keywords=* aging * dissertations * theses |full-text-url=https://sci-hub.do/10.1089/rej.2020.2378 }} {{medline-entry |title=Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32581723 |keywords=* aging * desialylation * galectin-3 * microglia * neurodegeneration * phagocytosis * sialic acid |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296093 }} {{medline-entry |title=Chemerin facilitates intervertebral disc degeneration via [[TLR4]] and CMKLR1 and activation of NF-kB signaling pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32526705 |keywords=* chemerin * inflammation * intervertebral disc * nucleus pulposus * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343479 }} {{medline-entry |title=Toll-like receptor 4 differentially regulates adult hippocampal neurogenesis in an age- and sex-dependent manner. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32343455 |keywords=* TLR4 * adult hippocampal neurogenesis * aging * proliferation * sex differences |full-text-url=https://sci-hub.do/10.1002/hipo.23209 }} {{medline-entry |title=Aging-associated immunosenescence via alterations in splenic immune cell populations in rat. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31838133 |mesh-terms=* Animals * B-Lymphocytes * Cells, Cultured * Immunity, Cellular * Immunosenescence * Male * Malondialdehyde * Oxidative Stress * Rats * Rats, Wistar * Spleen * Superoxide Dismutase * T-Lymphocytes |keywords=* Aging * Immunohistochemistry * Immunosenescence * Oxidative stress * Spleen |full-text-url=https://sci-hub.do/10.1016/j.lfs.2019.117168 }} {{medline-entry |title=Leptin induces immunosenescence in human B cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31831137 |mesh-terms=* Adult * Aged * B-Lymphocytes * Humans * Immunoglobulin Class Switching * Immunosenescence * Leptin * Middle Aged * Obesity |keywords=* B cells * Immunosenescence * Leptin * Obesity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002206 }} {{medline-entry |title=Genetic Variation in the Magnitude and Longevity of the IgG Subclass Response to a Diphtheria-Tetanus-Acellular Pertussis (DTaP) Vaccine in Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31547158 |keywords=* DTaP * IgG subclass * antibody longevity * antibody magnitude * genetics * vaccine |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963843 }} {{medline-entry |title=Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the [[TLR4]]/MyD88/NF‑κB signaling pathway. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31432123 |mesh-terms=* Aging * Animals * Autophagic Cell Death * Cognitive Dysfunction * Male * Myeloid Differentiation Factor 88 * NF-kappa B * Rats * Rats, Sprague-Dawley * Sevoflurane * Signal Transduction * Sirolimus * Toll-Like Receptor 4 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755174 }} ==TLR9== {{medline-entry |title=Age-Associated B Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31986068 |keywords=* B lymphocytes * aging * autoimmunity * memory B cells |full-text-url=https://sci-hub.do/10.1146/annurev-immunol-092419-031130 }} ==TMEM106B== {{medline-entry |title=Genetics of Gene Expression in the Aging Human Brain Reveal TDP-43 Proteinopathy Pathophysiology. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32526197 |mesh-terms=* Aged * Aged, 80 and over * Aging * Alzheimer Disease * Amyloid beta-Peptides * Apolipoproteins E * Brain * Cohort Studies * DNA-Binding Proteins * Female * Gene Expression Regulation * Haplotypes * Humans * Lysosomes * Male * Membrane Proteins * Myelin Sheath * Nerve Tissue Proteins * Progranulins * Quantitative Trait Loci * RNA Splicing Factors * TDP-43 Proteinopathies |keywords=* Alzheimer's disease * Amyloid-β * GRN * RBFOX1 * TDP-43 * TMEM106B * co-expression module * cognitive resilience * eQTL * expression quantitative trait loci * sQTL * splicing quantitative trait loci |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416464 }} ==TMPRSS2== {{medline-entry |title=Susceptibility to COVID-19 in populations with health disparities: Posited involvement of mitochondrial disorder, socioeconomic stress, and pollutants. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32905655 |keywords=* SARS-CoV-2 * dysfunction * exposome * immunosenescence * metabolomics * mitochondria * pollutant * socioeconomic * stress |full-text-url=https://sci-hub.do/10.1002/jbt.22626 }} {{medline-entry |title=Expression of the SARS-CoV-2 Entry Proteins, ACE2 and [[TMPRSS2]], in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32379417 |mesh-terms=* Age Factors * Angiotensin-Converting Enzyme 2 * Animals * Betacoronavirus * COVID-19 * Coronavirus Infections * Gene Expression * Gene Expression Profiling * Immunohistochemistry * In Situ Hybridization * Mice * Olfaction Disorders * Olfactory Mucosa * Olfactory Receptor Neurons * Pandemics * Peptidyl-Dipeptidase A * Pneumonia, Viral * RNA-Seq * Reverse Transcriptase Polymerase Chain Reaction * SARS-CoV-2 * Serine Endopeptidases * Virus Internalization |keywords=* ACE2 expression * COVID-19 * SARS-CoV-2 * aging * anosmia * olfactory epithelium |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241737 }} ==TNC== {{medline-entry |title=Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33217999 |keywords=* TGF-β * aging * collagen * extracellular matrix * fibroblast * skin * tenascin C |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698786 }} {{medline-entry |title=Tenascin-C expression controls the maturation of articular cartilage in mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32066496 |mesh-terms=* Aging * Animals * Cartilage, Articular * Cell Count * Genotype * Mice * Tenascin |keywords=* Adhesion * Articular cartilage * Cartilage defect * Cell density * Knock-out mouse * Load * Tenascin C |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027060 }} {{medline-entry |title=Effects of hydrothermal aging, thermal cycling, and water storage on the mechanical properties of a machinable resin-based composite containing nano-zirconia fillers. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31877525 |keywords=* Aging * Mechanical properties * Nano-zirconia * Phase transformation * Resin nano-ceramic * Resin-based composite |full-text-url=https://sci-hub.do/10.1016/j.jmbbm.2019.103522 }} ==TNF== {{medline-entry |title=Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe mice: role of SIRT1. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33234364 |keywords=* AML-12 cells * Aging * ApoE(−/−) mice * Naringenin * Nonalcoholic steatohepatitis * SIRT1 |full-text-url=https://sci-hub.do/10.1016/j.phymed.2020.153412 }} {{medline-entry |title=Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33212416 |keywords=* Aging * Ferroptosis * Heme oxygenase-1 * Iron metabolism * Microglia * Neuroinflammation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680814 }} {{medline-entry |title=Anti-aging effect of DL-β-hydroxybutyrate against hepatic cellular senescence induced by D-galactose or γ-irradiation via autophagic flux stimulation in male rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33147533 |keywords=* Autophagy * D-galacose * Ionizing radiation * Senescence * β-hydroxybutyric acid |full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104288 }} {{medline-entry |title=Exploring the extensive crosstalk between the antagonistic cytokines- TGF-β and [[TNF]]-α in regulating cancer pathogenesis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33153895 |keywords=* Apoptosis * Autophagy * EMT * Fibrogenesis * Senescence * TGF-β and TNF-α |full-text-url=https://sci-hub.do/10.1016/j.cyto.2020.155348 }} {{medline-entry |title=Long non-coding RNA SNHG29 regulates cell senescence via p53/p21 signaling in spontaneous preterm birth. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33080448 |keywords=* Cellular senescence * Oxidative stress * SASP * SNHG29 * Spontaneous preterm birth * p53/p21 |full-text-url=https://sci-hub.do/10.1016/j.placenta.2020.10.009 }} {{medline-entry |title=Cognition Is Associated With Peripheral Immune Molecules in Healthy Older Adults: A Cross-Sectional Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32983153 |keywords=* chemokines * cognition * cytokines * healthy aging * immune molecules |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493640 }} {{medline-entry |title=Anti-aging effects of [i]Ribes meyeri[/i] anthocyanins on neural stem cells and aging mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32920547 |keywords=* Ribes meyeri anthocyanin * aging * cognition * naringenin * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521483 }} {{medline-entry |title=Effects of a four week detraining period on physical, metabolic, and inflammatory profiles of elderly women who regularly participate in a program of strength training. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32863968 |keywords=* Aging * Inflammation * Physical exercise |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450596 }} {{medline-entry |title=Contribution of Porphyromonas gingivalis lipopolysaccharide to experimental periodontitis in relation to aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32851571 |keywords=* Aging * Bone loss * Osteoclastogenesis * Periodontitis * Porphyromonas gingivalis lipopolysaccharide |full-text-url=https://sci-hub.do/10.1007/s11357-020-00258-1 }} {{medline-entry |title=New MoDC-Targeting [[TNF]] Fusion Proteins Enhance Cyclic Di-GMP Vaccine Adjuvanticity in Middle-Aged and Aged Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32849581 |keywords=* 3′ * 5′-cyclic diguanylic acid (cyclic di-GMP) * aging * monocyte-derived dendritic cells (moDCs) * tumor necrosis factor (TNF) * vaccine |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427090 }} {{medline-entry |title=Cognitive impairment in elderly patients with rheumatic disease and the effect of disease-modifying anti-rheumatic drugs. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32862311 |keywords=* Aging * Biologics * Cognition * Rheumatic diseases |full-text-url=https://sci-hub.do/10.1007/s10067-020-05372-1 }} {{medline-entry |title=Cotinine ameliorates memory and learning impairment in senescent mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32818583 |keywords=* Aging * Cognitive impairment * Cotinine * Improvement * α(7)nAChRs |full-text-url=https://sci-hub.do/10.1016/j.brainresbull.2020.08.010 }} {{medline-entry |title=Kynurenines link chronic inflammation to functional decline and physical frailty. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32814718 |keywords=* Aging * Cytokines * Inflammation * Neurodegeneration |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455140 }} {{medline-entry |title=Voluntary exercise training attenuated the middle-aged maturity-induced cardiac apoptosis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32781061 |mesh-terms=* Aging * Animals * Apoptosis * Heart * In Situ Nick-End Labeling * Male * Mice * Mice, Inbred C57BL * Mitochondria, Heart * Muscle, Skeletal * Physical Conditioning, Animal * Running * Sedentary Behavior |keywords=* Caspase-independent * Cell death * Fas dependent * IGF-related * Mitochondrial |full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118187 }} {{medline-entry |title=Preclinical Evaluation of a Food-Derived Functional Ingredient to Address Skeletal Muscle Atrophy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32751276 |keywords=* aging * bioactive * functional ingredient * immobilization * inflammation * muscle atrophy * peptide * protein synthesis * skeletal muscle |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469066 }} {{medline-entry |title=Childhood survivors of high-risk neuroblastoma show signs of immune recovery and not immunosenescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32744364 |keywords=* adverse late effects * childhood * immune recovery * immunosenescence * neuroblastoma |full-text-url=https://sci-hub.do/10.1002/eji.202048541 }} {{medline-entry |title=FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32736525 |keywords=* Endothelial cells * Fk506 * Hyaluronan * LYVE-1 * Lung lymphatic * Senescence * TERT |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395348 }} {{medline-entry |title=Late-onset hypogonadism: Reductio ad absurdum of the cardiovascular risk-benefit of testosterone replacement therapy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32737921 |keywords=* aging * androgen * heart failure * myocardial infarction * testosterone * thromboembolism |full-text-url=https://sci-hub.do/10.1111/andr.12876 }} {{medline-entry |title=Doxorubicin generates senescent microglia that exhibit altered proteomes, higher levels of cytokine secretion, and a decreased ability to internalize amyloid β. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32738344 |keywords=* Aging * Alzheimer's disease * Inflammation * Microglia * Proteomics * Senescence |full-text-url=https://sci-hub.do/10.1016/j.yexcr.2020.112203 }} {{medline-entry |title=Time restricted feeding provides a viable alternative to alternate day fasting when evaluated in terms of redox homeostasis in rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32717588 |keywords=* Aging * Alternate day fasting (ADF) * Intermittent fasting (IF) * Oxidative stress * Time-Restricted feeding (TRF) |full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104188 }} {{medline-entry |title=Associations Between Plasma Immunomodulatory and Inflammatory Mediators With VACS Index Scores Among Older HIV-Infected Adults on Antiretroviral Therapy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32695109 |keywords=* HIV * aging * anti-retroviral therapy * inflammation * morbidity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338430 }} {{medline-entry |title=Chrysin Impact on Oxidative and Inflammation Damages in the Liver of Aged Male Rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32679027 |keywords=* Aging * chrysin * inflammation * liver * oxidative stress * rat. |full-text-url=https://sci-hub.do/10.2174/1871530320666200717162304 }} {{medline-entry |title=Correction of immunosuppression in aged septic rats by human ghrelin and growth hormone through the vagus nerve-dependent inhibition of TGF-β production. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32677895 |keywords=* Aging * Ghrelin * Immunosuppression * Sepsis * Vagus nerve |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364485 }} {{medline-entry |title=Epigenetics of neuroinflammation: Immune response, inflammatory response and cholinergic synaptic involvement evidenced by genome-wide DNA methylation analysis of delirious inpatients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32590150 |keywords=* Aging * Delirium * Genome-wide DNA methylation * Immune response * Inflammatory response |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486988 }} {{medline-entry |title=[i]Andrographis paniculata[/i] and Its Bioactive Diterpenoids Against Inflammation and Oxidative Stress in Keratinocytes. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32560449 |keywords=* Andrographis paniculata * andrographolide * inflammation * keratinocytes * oxidative stress * skin aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346124 }} {{medline-entry |title=Etanercept improves aging-induced cognitive deficits by reducing inflammation and vascular dysfunction in rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32569601 |keywords=* Aging * Etanercept * Inflammation * Learning * Memory * TNFα * Vascular dementia |full-text-url=https://sci-hub.do/10.1016/j.physbeh.2020.113019 }} {{medline-entry |title=Bacterial antigen translocation and age as BMI-independent contributing factors on systemic inflammation in NAFLD patients. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32559006 |keywords=* NAFLD * aging * bacterial translocation * cytokines * insulin resistance |full-text-url=https://sci-hub.do/10.1111/liv.14571 }} {{medline-entry |title=Bone marrow mesenchymal stem cells improve thymus and spleen function of aging rats through affecting P21/PCNA and suppressing oxidative stress. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32561691 |keywords=* BMSCs * P21/PCNA * aging * immune system * oxidative stress |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343510 }} {{medline-entry |title=Glycolic acid adjusted to pH 4 stimulates collagen production and epidermal renewal without affecting levels of proinflammatory [[TNF]]-alpha in human skin explants. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32583600 |keywords=* cosmetics * glycolic acid * keratolytic agents * rejuvenation * skin aging |full-text-url=https://sci-hub.do/10.1111/jocd.13570 }} {{medline-entry |title=A20 of nucleus pulposus cells plays a self-protection role via the nuclear factor-kappa B pathway in the inflammatory microenvironment. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32566144 |keywords=* A20 * Nuclear factor-kappa B * Nucleus pulposus * Senescence * Tumour necrosis factor alpha |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284293 }} {{medline-entry |title=Age-associated decline in neural, endocrine, and immune responses in men and women: Involvement of intracellular signaling pathways. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32563124 |mesh-terms=* Adult * Aging * Estradiol * Female * Humans * Hydrocortisone * Immunity, Cellular * Intracellular Fluid * Male * Middle Aged * Signal Transduction * Testosterone * Young Adult |keywords=* 17β-estradiol * Cortisol * Cytokines * Testosterone * Tyrosine hydroxylase |full-text-url=https://sci-hub.do/10.1016/j.jneuroim.2020.577290 }} {{medline-entry |title=Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32536956 |keywords=* Aging * Complement system * Elderly * Immune * Inflammation * Lectin |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285792 }} {{medline-entry |title=Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on aging-dependent male osteoporosis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32532246 |keywords=* Aging * FoxO1 * Male osteoporosois * OPG * RANKL * Resveratrol * SIRT1 * Type II osteoporosis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293127 }} {{medline-entry |title=The senescence-associated secretome as an indicator of age and medical risk. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32554926 |keywords=* Aging * Cellular senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406245 }} {{medline-entry |title=Exercise Partially Rejuvenates Muscle Stem Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32484032 |keywords=* TGF-beta * aging * cyclin D1 * longevity * regeneration * stem cells |full-text-url=https://sci-hub.do/10.1089/rej.2020.2359 }} {{medline-entry |title=Brazilian berry extract (Myrciaria jaboticaba): A promising therapy to minimize prostatic inflammation and oxidative stress. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32460430 |mesh-terms=* Age Factors * Animals * Anti-Inflammatory Agents * Antioxidants * Cyclooxygenase 2 * Diet, High-Fat * Dose-Response Relationship, Drug * Fruit * Interleukin-1beta * Interleukin-6 * Lipid Peroxidation * Male * Mice * Myrtaceae * Oxidative Stress * Plant Extracts * Prostatitis * T-Lymphocytes |keywords=* aging * bioactive compounds * obesity * overweight * polyphenols |full-text-url=https://sci-hub.do/10.1002/pros.24017 }} {{medline-entry |title=Potential therapeutic effects of endothelial cells trans-differentiated from Wharton's Jelly-derived mesenchymal stem cells on altered vascular functions in aged diabetic rat model. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32426041 |keywords=* Aging * Diabetes mellitus * Endothelial cells * Hypertension * Mesenchymal stem cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216374 }} {{medline-entry |title=[Effect of fragmented sleep on postoperative cognitive function and central neuroinflammation]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32375444 |mesh-terms=* Aging * Animals * Cognition * Cognition Disorders * Fear * Hippocampus * Mice * Mice, Inbred ICR |keywords=* Central nervous system * Cognition disorders * Inflammation * Postoperative period * Sleep deprivation |full-text-url=https://sci-hub.do/10.3760/cma.j.cn112137-20191215-02734 }} {{medline-entry |title=Can blocking inflammation enhance immunity during aging? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32386656 |keywords=* Inflammaging * p38-MAP Kinase * senescence * senolytics |full-text-url=https://sci-hub.do/10.1016/j.jaci.2020.03.016 }} {{medline-entry |title=[FAS- and [[TNF]]-dependent ways participation in apoptosis mechanisms in hypotalumus in physiological and pathological aging.] |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32362081 |mesh-terms=* Aging * Animals * Apoptosis * Female * Hypothalamus * Mice * Mice, Transgenic * Signal Transduction * Tumor Necrosis Factor-alpha * fas Receptor |keywords=* FAS-, TNF-dependent pathways * aging * apoptosis * hypothalamus * neurons }} {{medline-entry |title=Ultrasound-guided continuous thoracic paravertebral block alleviates postoperative delirium in elderly patients undergoing esophagectomy: A randomized controlled trial. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32332664 |mesh-terms=* Aged * Aged, 80 and over * Analgesia, Patient-Controlled * Delirium * Esophagectomy * Female * Geriatrics * Humans * Male * Middle Aged * Nerve Block * Postoperative Complications * Prospective Studies * Ultrasonography |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7440095 }} {{medline-entry |title=17β-Estradiol improves insulin signalling and insulin resistance in the aged female hearts: Role of inflammatory and anti-inflammatory cytokines. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32311377 |mesh-terms=* Aging * Animals * Anti-Inflammatory Agents * Blood Glucose * Cytokines * Estradiol * Female * Heart * Insulin * Insulin Resistance * Lipid Metabolism * Menopause * Ovariectomy * Rats * Rats, Wistar * Signal Transduction |keywords=* 17β-estradiol * Aging * Cytokines * Heart * Insulin signalling |full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.117673 }} {{medline-entry |title=Synergistic Antitumor Efficacy of Magnetohyperthermia and Poly(lactic-co-glycolic acid)-Encapsulated Selol in Ehrlich Breast Adenocarcinoma Treatment in Elderly Swiss Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32252879 |mesh-terms=* Adenocarcinoma * Aging * Animals * Cell Line, Tumor * Glycols * Humans * Mice * Nanoparticles * Polylactic Acid-Polyglycolic Acid Copolymer * Selenium Compounds |full-text-url=https://sci-hub.do/10.1166/jbn.2020.2890 }} {{medline-entry |title=Pinitol suppresses [[TNF]]-α-induced chondrocyte senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32200264 |keywords=* Cellular senescence * Nrf2 * Osteoarthritis * Pinitol * TNF-α |full-text-url=https://sci-hub.do/10.1016/j.cyto.2020.155047 }} {{medline-entry |title=[Aging of skin fibroblasts: genetic and epigenetic factors.] |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32160428 |mesh-terms=* Cells, Cultured * Epigenesis, Genetic * Fibroblasts * Humans * Skin Aging |keywords=* aging * melatonin * signal molecules * skin fibroblasts }} {{medline-entry |title=Functional and traditional training improve muscle power and reduce proinflammatory cytokines in older women: A randomized controlled trial. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32151735 |keywords=* Aging * Cytokines. * Dynapenia * Inflamm-aging |full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110920 }} {{medline-entry |title=Associations of [[TNF]]-α -308 G>A and [[TNF]]-β 252 A>G with Physical Function and BNP-Rugao Longevity and Ageing Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32115620 |mesh-terms=* Aged * Aged, 80 and over * Aging * Female * Humans * Longevity * Male * Natriuretic Peptide, Brain * Tumor Necrosis Factor-alpha |keywords=* Physical function * TNF-α -308 G>A polymorphism * TNF-β 252 A>G polymorphism * plasma BNP * population study. |full-text-url=https://sci-hub.do/10.1007/s12603-020-1336-1 }} {{medline-entry |title=3D TECA hydrogel reduces cellular senescence and enhances fibroblasts migration in wound healing. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32104405 |keywords=* 3D TECA * Cellular senescence * Fibroblast migration * SA-β-gal * TNF-α |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032142 }} {{medline-entry |title=Regulatory Effect of Anwulignan on the Immune Function Through Its Antioxidation and Anti-Apoptosis in D-Galactose-Induced Aging Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32099340 |mesh-terms=* Animals * Antioxidants * Apoptosis * Cytokines * Immunologic Factors * Immunosenescence * Male * Medicine, Chinese Traditional * Mice * Models, Animal * NF-E2-Related Factor 2 * Oxidative Stress * Phytochemicals * Schisandra * Spleen |keywords=* Anwulignan * anti-apoptosis * antioxidation * immunosenescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996228 }} {{medline-entry |title=Pretreatment Frailty Is Independently Associated With Increased Risk of Infections After Immunosuppression in Patients With Inflammatory Bowel Diseases. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32105728 |keywords=* Aging * Immunosuppression * Side Effect * Thiopurine |full-text-url=https://sci-hub.do/10.1053/j.gastro.2020.02.032 }} {{medline-entry |title=The Citrus Flavonoid Naringenin Protects the Myocardium from Ageing-Dependent Dysfunction: Potential Role of SIRT1. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32047577 |mesh-terms=* Aging * Animals * Antioxidants * Cell Line * Cellular Senescence * Citrus * Cytoprotection * Disease Models, Animal * Flavanones * Humans * Interleukin-6 * Mice * Myocardium * Protein Binding * Rats * Reactive Oxygen Species * Sirtuin 1 * Tumor Necrosis Factor-alpha |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003265 }} {{medline-entry |title=In the Absence of a TCR Signal IL-2/IL-12/18-Stimulated γδ T Cells Demonstrate Potent Anti-Tumoral Function Through Direct Killing and Senescence Induction in Cancer Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31947966 |keywords=* IL-12 * IL-18 * TCR bypass stimulation * senescence * γδ T cells |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017313 }} {{medline-entry |title=Aging is associated with loss of beneficial effects of estrogen on leptin responsiveness in mice fed high fat diet: Role of estrogen receptor α and cytokines. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31904410 |keywords=* Aging * Cytokines * ERα * Estrogen * Leptin sensitivity |full-text-url=https://sci-hub.do/10.1016/j.mad.2019.111198 }} {{medline-entry |title=Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31885820 |mesh-terms=* Aging * Alzheimer Disease * Amyloid beta-Peptides * Animals * Cytokines * Humans * Inflammation Mediators * Mitochondria * Neurofibrillary Tangles * Neurons * Neuroprotective Agents * Thioctic Acid |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914903 }} {{medline-entry |title=Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31837501 |mesh-terms=* Aging * Alzheimer Disease * Amyloid beta-Peptides * Animals * Anti-Inflammatory Agents, Non-Steroidal * Astrocytes * Carbamates * Cell Line, Tumor * Cell Survival * Diosgenin * Dose-Response Relationship, Drug * Drug Design * Galactose * Humans * Inflammation * Male * Mice * Mice, Inbred ICR * Molecular Structure * Neuroprotective Agents * Oxidative Stress * Protein Aggregates * Structure-Activity Relationship |keywords=* Alzheimer’s disease * Anti-Aβ activity * Anti-inflammatory * Antioxidant * Diosgenin * Multi-target-directed ligands |full-text-url=https://sci-hub.do/10.1016/j.ejmech.2019.111913 }} {{medline-entry |title=Oral Administration of Okara Soybean By-Product Attenuates Cognitive Impairment in a Mouse Model of Accelerated Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31816987 |mesh-terms=* Aging * Animal Feed * Animals * Brain-Derived Neurotrophic Factor * Cognitive Dysfunction * Diet * Gastrointestinal Microbiome * Gene Expression Regulation * Hippocampus * Male * Mice * Soybeans * Tumor Necrosis Factor-alpha |keywords=* BDNF * SAMP8 * cognitive impairment * neuroprotection * okara |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950093 }} {{medline-entry |title=Electric vagal nerve stimulation inhibits inflammation and improves early postoperation cognitive dysfunction in aged rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31759387 |mesh-terms=* Aging * Anesthesia, General * Animals * Behavior, Animal * Hippocampus * Inflammation * Male * Maze Learning * NF-kappa B * Postoperative Cognitive Complications * Rats * Rats, Sprague-Dawley * Splenectomy * Tumor Necrosis Factor-alpha * Vagus Nerve Stimulation |keywords=* Cognitive dysfunction * General anesthesia * Inflammation * Vagus nerve stimulation |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875068 }} {{medline-entry |title=Metformin decreases LPS-induced inflammatory response in rabbit annulus fibrosus stem/progenitor cells by blocking HMGB1 release. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31772144 |mesh-terms=* Animals * Annulus Fibrosus * Anti-Inflammatory Agents * Cellular Senescence * HMGB1 Protein * Inflammation * Intervertebral Disc Degeneration * Lipopolysaccharides * Metformin * Rabbits * Stem Cells |keywords=* HMGB1 * annulus fibrosis stem cells * cell senescence * intervertebral disc degeneration * metformin |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914423 }} {{medline-entry |title=The effects of blueberry and strawberry serum metabolites on age-related oxidative and inflammatory signaling in vitro. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31746877 |mesh-terms=* Aged * Aging * Animals * Blueberry Plants * Double-Blind Method * Female * Fragaria * Fruit * Humans * Male * Microglia * Middle Aged * Nitric Oxide * Nitric Oxide Synthase Type II * Oxidative Stress * Postprandial Period * Rats * Tumor Necrosis Factor-alpha |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906224 }} {{medline-entry |title=Arsenic induces human chondrocyte senescence and accelerates rat articular cartilage aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31734849 |keywords=* Aging * Arsenic * Articular cartilage * Human chondrocyte * Senescence * Senescence-associated secretory phenotype |full-text-url=https://sci-hub.do/10.1007/s00204-019-02607-2 }} {{medline-entry |title=Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31717258 |mesh-terms=* Age Factors * Animals * Bone Density * Bone Density Conservation Agents * Bone Marrow Cells * Bone Remodeling * Bone and Bones * Cells, Cultured * Cytokines * Dietary Supplements * Disease Models, Animal * Docosahexaenoic Acids * Eicosapentaenoic Acid * Female * JNK Mitogen-Activated Protein Kinases * Mice, Inbred C57BL * Osteoporosis * Signal Transduction * p38 Mitogen-Activated Protein Kinases |keywords=* aging * bone mineral density * bone resorption * concentrated fish oil * cytokines * inflammation * omega-3 fatty acids |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893665 }} {{medline-entry |title=Inflammaging phenotype in rhesus macaques is associated with a decline in epithelial barrier-protective functions and increased pro-inflammatory function in CD161-expressing cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31713098 |mesh-terms=* Aging * Animals * Chronic Disease * Cytokines * Disease Models, Animal * Epithelium * Flow Cytometry * Immunity, Innate * Inflammation * Macaca mulatta * NK Cell Lectin-Like Receptor Subfamily B * Phenotype * Th17 Cells |keywords=* CD161+ cells * I-FABP * Inflammaging * LBP * Leaky gut * sCD14 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925095 }} {{medline-entry |title=Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31719197 |mesh-terms=* Adult * Aged * Aged, 80 and over * B-Lymphocytes * CD4-Positive T-Lymphocytes * Case-Control Studies * Cell Differentiation * Cells, Cultured * Clonal Evolution * Gene Expression Profiling * Humans * Interferon-gamma * Leukocytes, Mononuclear * Middle Aged * Single-Cell Analysis * Tumor Necrosis Factor-alpha |keywords=* CD4 CTL * aging * centenarian * single-cell transcriptome |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883788 }} {{medline-entry |title=Gut microbiota combined with metabolomics reveals the metabolic profile of the normal aging process and the anti-aging effect of FuFang Zhenshu TiaoZhi(FTZ) in mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31704617 |mesh-terms=* Aging * Animals * Bacteria * Biomarkers * Drugs, Chinese Herbal * Gastrointestinal Microbiome * Hyperlipidemias * Lipid Metabolism * Male * Metabolome * Metabolomics * Mice * Mice, Inbred C57BL |keywords=* Aging * FTZ * Gut microbiota * Metabolomics |full-text-url=https://sci-hub.do/10.1016/j.biopha.2019.109550 }} {{medline-entry |title=Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31669486 |mesh-terms=* Aging * Animals * Apoptosis * Cytokines * Estrogens * Female * Humans * Inflammation * Intervertebral Disc * Intervertebral Disc Degeneration * Intervertebral Disc Displacement * Male * Phosphatidylinositol 3-Kinases * Signal Transduction |keywords=* Ageing * Apoptosis * Intervertebral disc degeneration * Oestrogen * Spine |full-text-url=https://sci-hub.do/10.1016/j.arr.2019.100978 }} {{medline-entry |title=MicroRNA 16-5p is upregulated in calorie-restricted mice and modulates inflammatory cytokines of macrophages. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31654705 |mesh-terms=* Aging * Animals * Caloric Restriction * Cytokines * Diet Therapy * Inflammation * Interleukin-1beta * Macrophages * Male * Mice * Mice, Inbred C57BL * MicroRNAs * Models, Animal * RAW 264.7 Cells * Transcriptional Activation * Tumor Necrosis Factor-alpha * Up-Regulation |keywords=* Caloric restriction * Cellular immunology * Cytokines * Macrophages * microRNA |full-text-url=https://sci-hub.do/10.1016/j.gene.2019.144191 }} {{medline-entry |title=Aerobic exercise modulates cytokine profile and sleep quality in elderly. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31656505 |mesh-terms=* Aged * Cytokines * Exercise * Female * Humans * Male * Middle Aged * Sedentary Behavior * Sleep Wake Disorders |keywords=* Sleep quality * aerobic exercise * aging * inflammatory cytokines |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794533 }} {{medline-entry |title=Trehalose targets Nrf2 signal to alleviate d-galactose induced aging and improve behavioral ability. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31630800 |mesh-terms=* Aging * Animals * Disease Models, Animal * Dose-Response Relationship, Drug * Galactose * Male * Memory Disorders * Mice * Mice, Inbred ICR * NF-E2-Related Factor 2 * Signal Transduction * Trehalose |keywords=* Antioxidant stress * Cognitive impairment * Inflammation * Nrf2 * Trehalose * d-galactose |full-text-url=https://sci-hub.do/10.1016/j.bbrc.2019.10.088 }} {{medline-entry |title=Anti-Inflammatory and Anti-Aging Evaluation of Pigment-Protein Complex Extracted from [i]Chlorella Pyrenoidosa[/i]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31623220 |mesh-terms=* Aging * Animals * Anti-Inflammatory Agents * Antioxidants * Biological Products * Chlorella * Cytokines * Disease Models, Animal * Galactose * Inflammation * Interleukin-6 * Lipopolysaccharides * Macrophages * Male * Mice * Mice, Inbred C57BL * NF-kappa B * Nitric Oxide * Oxidative Stress * RAW 264.7 Cells * Superoxide Dismutase * Tumor Necrosis Factor-alpha |keywords=* Chlorella pyrenoidosa * NF-κB * PPARs * anti-aging * anti-inflammation * pigment–protein complex |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836285 }} {{medline-entry |title=Inflammatory mediators and the risk of falls among older women with acute low back pain: data from Back Complaints in the Elders (BACE)-Brazil. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31606818 |keywords=* Aging * BACE * Cytokines * Disability * Fall risk * Low back pain |full-text-url=https://sci-hub.do/10.1007/s00586-019-06168-x }} {{medline-entry |title=Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31583530 |keywords=* Acetylcholinesterase inhibitor * Aging * CHRFAM7A * CHRNA7 * Cholinergic anti-inflammatory pathway * Neuroinflammation |full-text-url=https://sci-hub.do/10.1007/s40520-019-01359-4 }} {{medline-entry |title=Study on Metabolic Trajectory of Liver Aging and the Effect of Fufang Zhenzhu Tiaozhi on Aging Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31555127 |keywords=* Fufang Zhenzhu Tiaozhi * liver aging * mass spectrometry * metabolomics * ultra-performance liquid chromatography |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722462 }} {{medline-entry |title=Systemic Tumor Necrosis Factor-Alpha Trajectories Relate to Brain Health in Typically Aging Older Adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31549145 |keywords=* Brain aging * Cognition * Gray matter volume * Inflammation * Neuroimaging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457183 }} {{medline-entry |title=Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31521202 |mesh-terms=* Adipose Tissue * Adult * Cell Movement * Cell Proliferation * Cell Survival * Cellular Senescence * Dasatinib * Female * Humans * Mesenchymal Stem Cells * Pre-Eclampsia * Pregnancy * Protein Kinase Inhibitors |keywords=* Angiogenesis, Senolytics, Dasatinib * Mesenchymal stem cells * Preeclampsia * Senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744626 }} {{medline-entry |title=Suppression of gut dysbiosis by Bifidobacterium longum alleviates cognitive decline in 5XFAD transgenic and aged mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31413350 |mesh-terms=* Aging * Animals * Bifidobacterium longum * Cognitive Dysfunction * Dysbiosis * Feces * Gastrointestinal Microbiome * Humans * Lipopolysaccharides * Mice * Mice, Transgenic * Probiotics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694197 }} {{medline-entry |title=Moderate hyperoxia induces senescence in developing human lung fibroblasts. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31411059 |mesh-terms=* Autophagy * CCAAT-Enhancer-Binding Protein-beta * Cell Proliferation * Cellular Senescence * Cyclin-Dependent Kinase Inhibitor p21 * DNA Damage * Endoplasmic Reticulum Stress * Etoposide * Extracellular Matrix * Fetus * Fibroblasts * G2 Phase Cell Cycle Checkpoints * Gene Expression Regulation * Humans * Hyperoxia * Interleukin-1 * Interleukin-8 * Lung * Matrix Metalloproteinase 3 * Oxygen * Plasminogen Activator Inhibitor 1 * Primary Cell Culture * Tumor Necrosis Factor-alpha * Tumor Suppressor Protein p53 |keywords=* autophagy * endoplasmic reticulum stress * lung development * oxygen * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879905 }} {{medline-entry |title=Aging-related carcinoembryonic antigen-related cell adhesion molecule 1 signaling promotes vascular dysfunction. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31389127 |mesh-terms=* Aged * Aging * Animals * Antigens, CD * Cell Adhesion Molecules * Cells, Cultured * Endothelium, Vascular * Humans * Mice * Mice, Inbred C57BL * Mice, Knockout * Middle Aged * Signal Transduction |keywords=* aging * anti-aging * cytokines * inflammation * mouse * reactive oxygen species |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826129 }} {{medline-entry |title=Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APP /PS1 Transgenic Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31417357 |keywords=* aging * cerebral amyloidosis * insulin-like growth factor * neurogenesis * neuroinflammation * tumor necrosis factor |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682662 }} {{medline-entry |title=Age- and diet-specific effects of chronic exposure to chlorpyrifos on hormones, inflammation and gut microbiota in rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31400786 |mesh-terms=* Aging * Animals * Chlorpyrifos * Diet, High-Fat * Gastrointestinal Microbiome * Hypothalamo-Hypophyseal System * Inflammation * Male * Pituitary-Adrenal System * RNA, Ribosomal, 16S * Rats |keywords=* 16S rRNA gene sequencing * Gut endocrine * Gut-brain axis * Hormone * Hypothalamic-pituitary-adrenal axis * Inflammation |full-text-url=https://sci-hub.do/10.1016/j.pestbp.2019.05.018 }} ==TOMM20== {{medline-entry |title=Effect of aging on mitochondria and metabolism of bovine granulosa cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32921645 |keywords=* Aging * Cow * Granulosa cells * Mitochondria |full-text-url=https://sci-hub.do/10.1262/jrd.2020-071 }} ==TP53== {{medline-entry |title=p53 inhibits the osteogenic differentiation but does not induce senescence in human dental follicle cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32473528 |keywords=* Cellular senescence * Dental follicle cells * E2F-1 * Osteogenic differentiation * p53 |full-text-url=https://sci-hub.do/10.1016/j.diff.2020.05.003 }} {{medline-entry |title=Mutational spectrum and dynamics of clonal hematopoiesis in anemia of older individuals. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32243522 |mesh-terms=* Age Factors * Aged * Aging * Anemia * Female * Hematopoiesis * Humans * Kaplan-Meier Estimate * Male * Middle Aged * Mutation * Prospective Studies |full-text-url=https://sci-hub.do/10.1182/blood.2019004362 }} {{medline-entry |title=[[TP53]]/miR-34a-associated signaling targets [i]SERPINE1[/i] expression in human pancreatic cancer. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31986125 |keywords=* Aging * PDAC * SERPINE1 * TP53 * cancer * miR-34a |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041729 }} {{medline-entry |title=Expression of p16 in nodular fasciitis: an implication for self-limited and inflammatory nature of the lesion. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31933915 |keywords=* CDK4 * MDM2 * TP53 * nodular fasciitis * p16 * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945175 }} ==TPH1== {{medline-entry |title=[i]Lactobacillus plantarum[/i] DR7 improved brain health in aging rats via the serotonin, inflammatory and apoptosis pathways. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33245015 |keywords=* Lactobacillus spp. * aging * brain |full-text-url=https://sci-hub.do/10.3920/BM2019.0200 }} ==TPO== {{medline-entry |title=Megakaryocytes promote osteoclastogenesis in aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32634116 |keywords=* aging * bone marrow macrophage * megakaryocyte * osteoclast * thrombopoietin |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425434 }} ==TPP1== {{medline-entry |title=FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33086033 |keywords=* DNA damage response * FBXW7 * TPP1 * cellular senescence * chronic stress * idiopathic pulmonary fibrosis * premature aging * proteostasis * stem cells * telomere * telomere uncapping |full-text-url=https://sci-hub.do/10.1016/j.cmet.2020.10.004 }} ==TPR== {{medline-entry |title=Catalytic Performances of Cu/MCM-22 Zeolites with Different Cu Loadings in NH -SCR. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143192 |keywords=* Cu loading * Cu/MCM-22 * NH3-SCR * hydrothermal aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694057 }} {{medline-entry |title=Do traits of plant species predict the efficacy of species distribution models for finding new occurrences? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32551077 |keywords=* dispersal * generalist * lifespan * niche models * range size * specialist |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297770 }} {{medline-entry |title=In-situ modified the surface of Pt-doped perovskite catalyst for soot oxidation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31541957 |keywords=* Aging resistance * Amorphization * Surface modification * Symmetrical structure |full-text-url=https://sci-hub.do/10.1016/j.jhazmat.2019.121210 }} ==TRAF3== {{medline-entry |title=[[TRAF3]], a Target of MicroRNA-363-3p, Suppresses Senescence and Regulates the Balance Between Osteoblastic and Adipocytic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32111144 |keywords=* TRAF3 * adipogenic differentiation * bone marrow-derived mesenchymal stem cells * miR-363-3p * osteogenic differentiation * senescence |full-text-url=https://sci-hub.do/10.1089/scd.2019.0276 }} ==TREM2== {{medline-entry |title=Loss of [[TREM2]] Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33139402 |keywords=* TREM2 * aging * dendritic spine density * learning and memory * long-term potentiation * synaptic plasticity |full-text-url=https://sci-hub.do/10.1523/JNEUROSCI.2193-20.2020 }} {{medline-entry |title=Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer's Disease Brain. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33101276 |keywords=* NKG2D ligands * aging * inflammation * interferon type I response * microglia * neurodegeneration * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546799 }} {{medline-entry |title=Knockdown of astrocytic [[TREM2]] in the hippocampus relieves cognitive decline in elderly male mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32991925 |keywords=* Aging * Long-term potentiation * TREM2 * astrocytes * learning and memory |full-text-url=https://sci-hub.do/10.1016/j.bbr.2020.112939 }} ==TRIM21== {{medline-entry |title=[[TRIM21]] overexpression promotes tumor progression by regulating cell proliferation, cell migration and cell senescence in human glioma. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32064156 |keywords=* Glioma * TRIM21 * cell senescence * drug resistance * p53-p21 pathway * prognosis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017742 }} ==TRIM27== {{medline-entry |title=[[TRIM27]] Functions as a Novel Oncogene in Non-Triple-Negative Breast Cancer by Blocking Cellular Senescence through p21 Ubiquitination. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33251042 |keywords=* EP300 * TRIM27 * breast cancer * cell apoptosis * cell senescence * chemoresistance * p21 * prognosis * transcription * ubiquitination |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666371 }} ==TRIP13== {{medline-entry |title=BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31738183 |mesh-terms=* Aging * Alleles * Animals * Cell Cycle Proteins * Chromosome Disorders * Lung Neoplasms * Mice * Mice, Inbred C57BL * Mitosis * Mosaicism * Mutation * Phenotype * Progeria * Protein-Serine-Threonine Kinases |keywords=* Aging * Cancer * Cellular senescence * Genetic diseases * Oncology |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934189 }} ==TRPC6== {{medline-entry |title=Redox and mTOR-dependent regulation of plasma lamellar calcium influx controls the senescence-associated secretory phenotype. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32686475 |keywords=* SASP * Senescence * TRPC6 * calcium * hydrogen peroxide * mTOR |full-text-url=https://sci-hub.do/10.1177/1535370220943122 }} ==TRPC7== {{medline-entry |title=Nociceptive transient receptor potential canonical 7 ([[TRPC7]]) mediates aging-associated tumorigenesis induced by ultraviolet B. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31755176 |keywords=* TRPC7 * aging * p53 * tumor initiator gene * tumorigenesis * ultraviolet pathology |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974716 }} ==TRPV4== {{medline-entry |title=[[TRPV4]] receptor as a functional sensory molecule in bladder urothelium: Stretch-independent, tissue-specific actions and pathological implications. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31914645 |mesh-terms=* Animals * Calcium * Guinea Pigs * Humans * Muscle Contraction * Muscle, Smooth * TRPV Cation Channels * Urinary Bladder * Urothelium |keywords=* ATP release * TRPV4 receptor * aging * overactive bladders * urothelium |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973053 }} {{medline-entry |title=Exercise restores impaired endothelium-derived hyperpolarizing factor-mediated vasodilation in aged rat aortic arteries via the [[TRPV4]]-K 2.3 signaling complex. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31564840 |mesh-terms=* Animals * Biological Factors * Cardiovascular Diseases * Endothelial Cells * Endothelium, Vascular * Male * Potassium Channels, Calcium-Activated * Rats * Rats, Sprague-Dawley * TRPV Cation Channels * Vasodilation |keywords=* EDHF * KCa2.3 * TRPV4 * aging * endothelium * exercise |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731547 }} ==TSPO== {{medline-entry |title=Age and Sex Influence the Neuro-inflammatory Response to a Peripheral Acute LPS Challenge. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31749696 |keywords=* 18 kDa translocator protein * aging * astrocytes * microglia * neuroinflammation * triggering receptor expressed on myeloid cells 2 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848890 }} {{medline-entry |title=Upregulation of cannabinoid receptor type 2, but not [[TSPO]], in senescence-accelerated neuroinflammation in mice: a positron emission tomography study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31707986 |mesh-terms=* Aging * Animals * Brain * Inflammation * Mice * Microglia * Positron-Emission Tomography * Radiopharmaceuticals * Receptor, Cannabinoid, CB2 * Receptors, GABA * Up-Regulation |keywords=* Cannabinoid receptor type 2 * Immunostaining * Microglial activation * Positron emission tomography * Senescence-accelerated prone mouse * Translocator protein |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842455 }} ==TST== {{medline-entry |title=H S Donors Reverse Age-Related Gastric Malfunction Impaired Due to Fructose-Induced Injury [i]via[/i] CBS, CSE, and [[TST]] Expression. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32848752 |keywords=* aging * donor * fructose * gastric mucosa * hydrogen sulfide * oxidative stress |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396573 }} {{medline-entry |title=Adaptations in mechanical muscle function, muscle morphology, and aerobic power to high-intensity endurance training combined with either traditional or power strength training in older adults: a randomized clinical trial. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32239311 |keywords=* Aging * Concurrent training * Explosive force * Functional capacity * HIIT |full-text-url=https://sci-hub.do/10.1007/s00421-020-04355-z }} {{medline-entry |title=Digital phenotyping by consumer wearables identifies sleep-associated markers of cardiovascular disease risk and biological aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31602410 |mesh-terms=* Adult * Aged * Aging * Body Mass Index * Cardiovascular Diseases * Cohort Studies * Female * Humans * Male * Middle Aged * Risk Factors * Self Report * Sleep * Telomere * Waist Circumference * Wearable Electronic Devices * Young Adult |keywords=* Data integration * Predictive markers * Risk factors * Senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778117 }} {{medline-entry |title=Objective Sleep Duration in Older Adults: Results From The Irish Longitudinal Study on Ageing. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31579942 |mesh-terms=* Accelerometry * Aged * Aging * Cross-Sectional Studies * Exercise * Female * Health Status * Humans * Independent Living * Ireland * Longitudinal Studies * Male * Polysomnography * Self Report * Sleep * Time Factors |keywords=* GENEActiv * accelerometer * actigraphy * older population * sleep duration |full-text-url=https://sci-hub.do/10.1111/jgs.16177 }} ==TTL== {{medline-entry |title=Longitudinal Associations of Body Mass Index, Waist Circumference, and Waist-to-Hip Ratio with Biomarkers of Oxidative Stress in Older Adults: Results of a Large Cohort Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31986512 |mesh-terms=* Aged * Aged, 80 and over * Aging * Biomarkers * Body Mass Index * Cohort Studies * Female * Germany * Humans * Longitudinal Studies * Male * Middle Aged * Oxidative Stress * Waist Circumference * Waist-Hip Ratio |keywords=* Body mass index * Free radicals * Oxidative stress * Reactive oxygen metabolites * Total thiol levels * Waist circumference * Waist-to-hip ratio |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098284 }} ==TTN== {{medline-entry |title=LncRNA [[TTN]]-AS1 regulates osteosarcoma cell apoptosis and drug resistance via the miR-134-5p/MBTD1 axis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31600142 |mesh-terms=* Aging * Apoptosis * Brain Neoplasms * Cell Line, Tumor * Cell Proliferation * Chromosomal Proteins, Non-Histone * Computational Biology * Drug Resistance * Gene Expression Regulation, Neoplastic * Humans * MicroRNAs * Osteosarcoma * RNA, Long Noncoding |keywords=* aging and age-related diseases * lncRNA TTN-AS1 * malignant brain tumour domain containing protein 1 * miR-134-5p * osteosarcoma * resistance |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814585 }} ==TTR== {{medline-entry |title=Cellular secretion and cytotoxicity of transthyretin mutant proteins underlie late-onset amyloidosis and neurodegeneration. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31728576 |mesh-terms=* Amyloid Neuropathies, Familial * Animals * Cell Death * Cell Line, Tumor * Disease Models, Animal * Drosophila * HEK293 Cells * Humans * Locomotion * Longevity * Mutant Proteins * Mutation * Nerve Degeneration * Prealbumin |keywords=* Amyloidosis * Drosophila melanogaster * ERQC * Endoplasmic reticulum quality control * Proteostasis * TTR * Transthyretin |full-text-url=https://sci-hub.do/10.1007/s00018-019-03357-1 }} ==TXNIP== {{medline-entry |title=Panax notoginseng saponins attenuate neuroinflammation through [[TXNIP]]-mediated NLRP3 inflammasome activation in aging rats. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33176641 |keywords=* Aging * Microglia * NLRP3 inflammasome * Saponins from Panax notoginseng. * TXNIP * neuroinflammation |full-text-url=https://sci-hub.do/10.2174/1389201021999201110204735 }} {{medline-entry |title=Redox homeostasis and cell cycle activation mediate beta-cell mass expansion in aged, diabetes-prone mice under metabolic stress conditions: Role of thioredoxin-interacting protein ([[TXNIP]]). |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33128997 |keywords=* Aging * Beta-cells * Cell cycle * Metabolic stress * Redox homeostasis * Thioredoxin-interacting protein |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589534 }} {{medline-entry |title=[Effect of diabetic induced thioredoxin interacting protein ([[TXNIP]]) on islet cell senescence]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32744003 |mesh-terms=* Animals * Carrier Proteins * Cellular Senescence * Diabetes Mellitus, Experimental * Islets of Langerhans * Mice * Thioredoxins |keywords=* INS-1 cell * cell senescence * diabetes * thioredoxin interacting protein |full-text-url=https://sci-hub.do/10.12047/j.cjap.5878.2020.027 }} {{medline-entry |title=PRMT5-TRIM21 interaction regulates the senescence of osteosarcoma cells by targeting the [[TXNIP]]/p21 axis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32023548 |keywords=* PRMT5 * TRIM21 * TXNIP * p21 * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041745 }} ==TXNRD2== {{medline-entry |title=Wogonin induces cellular senescence in breast cancer via suppressing [[TXNRD2]] expression. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32671444 |keywords=* Breast cancer * Immune surveillance * ROS * Senescence * TXNRD2 * Wogonin |full-text-url=https://sci-hub.do/10.1007/s00204-020-02842-y }} ==U2AF1== {{medline-entry |title=Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic analysis of mRNA splicing relevant proteins in aging HSPCs. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32141009 |keywords=* Aging * DEPs * HSPC * iTRAQ * mRNA splicing |full-text-url=https://sci-hub.do/10.1007/s40520-020-01509-z }} ==UACA== {{medline-entry |title=Knockdown of [i][[UACA]][/i] inhibitsproliferation and invasion and promotes senescence of hepatocellular carcinoma cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31949867 |keywords=* HIF1α * UACA * hepatocellular carcinoma * invasion * knockdown * proliferation * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962967 }} ==UCHL1== {{medline-entry |title=Abolishing [[UCHL1]]'s hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33159930 |keywords=* Aging * Axonal injury * Neurodegeneration * Traumatic brain injury * Ubiquitin carboxy terminal hydrolase L1 * Ubiquitin proteasome pathway |full-text-url=https://sci-hub.do/10.1016/j.expneurol.2020.113524 }} ==UCP1== {{medline-entry |title=Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32464603 |keywords=* adipose tissue * aging * growth hormone * inflammation * uncoupling protein 1 (UCP1) |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288969 }} {{medline-entry |title=Lack of [[UCP1]] stimulates fatty liver but mediates [[UCP1]]-independent action of beige fat to improve hyperlipidemia in Apoe knockout mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32179129 |keywords=* Apoe knockout mice * Beige fat * Gene expression * Hyperlipidemia * Longevity * Uncoupling protein 1 |full-text-url=https://sci-hub.do/10.1016/j.bbadis.2020.165762 }} {{medline-entry |title=Postnatal leptin surge is critical for the transient induction of the developmental beige adipocytes in mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31961706 |mesh-terms=* Adipocytes, Beige * Adipocytes, White * Adipose Tissue * Aging * Animals * Dose-Response Relationship, Drug * Female * Leptin * Male * Mice * Mice, Obese * Sympathetic Nervous System * Tyrosine 3-Monooxygenase * Uncoupling Protein 1 |keywords=* beige adipocytes * leptin * sympathetic nerve system |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191411 }} {{medline-entry |title=Age-related sex differences in the expression of important disease-linked mitochondrial proteins in mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31806023 |mesh-terms=* Adipose Tissue, Brown * Aging * Animals * Brain * Female * Male * Mice, Inbred C57BL * Mitochondrial Proteins * Muscle, Skeletal * Sex Characteristics * Spleen |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896328 }} {{medline-entry |title=An anti-inflammatory phenotype in visceral adipose tissue of old lean mice, augmented by exercise. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31427677 |mesh-terms=* Adipocytes * Aging * Animals * Humans * Inflammation * Intra-Abdominal Fat * Macrophages * Mice * Obesity * Phenotype * Physical Conditioning, Animal * Resistance Training |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700172 }} ==UGT2B28== {{medline-entry |title=Ages of hepatocellular carcinoma occurrence and life expectancy are associated with a [[UGT2B28]] genomic variation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31805979 |mesh-terms=* Adult * Age of Onset * Aged * Aged, 80 and over * Carcinoma, Hepatocellular * Female * Genetic Association Studies * Genetic Predisposition to Disease * Glucuronosyltransferase * Humans * Life Expectancy * Liver Neoplasms * Male * Middle Aged * Neoplasm Metastasis * Neoplasm Recurrence, Local * Odds Ratio * Polymorphism, Single Nucleotide * Survival Analysis * Young Adult |keywords=* Alcoholism * Xenobiotic metabolizing enzymes * Young hepatocellular carcinoma; age of death |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896495 }} ==USP7== {{medline-entry |title=Deubiquitinase [[USP7]] regulates [i]Drosophila[/i] aging through ubiquitination and autophagy. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33221768 |keywords=* DMC * Drosophila * USP7 * aging * autophagy |full-text-url=https://sci-hub.do/10.18632/aging.104067 }} ==VCAM1== {{medline-entry |title=Sunitinib facilitates metastatic breast cancer spreading by inducing endothelial cell senescence. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32993785 |keywords=* Cell senescence * Metastasis * Metastatic breast cancer (MBC) * Receptor tyrosine kinase (RTK) * Sunitinib |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7526390 }} ==VDAC1== {{medline-entry |title=Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and [[VDAC1]] predicts mammalian longevity. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32353747 |keywords=* Complex I * Droplet digital PCR * Longevity * Mammals * Mitochondria * NDUFS4 subunit * NDUFV2 subunit * VDAC * Western blot |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191849 }} {{medline-entry |title=Changes in the expression of oxidative phosphorylation complexes in the aging intestinal mucosa. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32173460 |keywords=* Aging * Colonic crypt * Expression * Intestine * Mitochondria * OXPHOS |full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110924 }} ==VDR== {{medline-entry |title=25-Hydroxyvitamin D positively regulates periodontal inflammaging via SOCS3/STAT signaling in diabetic mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31917967 |keywords=* 25-Hydroxyvitamin D(3) * Diabetic periodontitis * Inflammaging * SOCS3 * Senescence * Senescence-associated secretory phenotypes |full-text-url=https://sci-hub.do/10.1016/j.steroids.2019.108570 }} {{medline-entry |title=1,25-Dihydroxyvitamin D protects against age-related osteoporosis by a novel [[VDR]]-Ezh2-p16 signal axis. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31880094 |mesh-terms=* 25-Hydroxyvitamin D3 1-alpha-Hydroxylase * Aging * Animals * Bone and Bones * Cells, Cultured * Cyclin-Dependent Kinase Inhibitor p16 * Cyclin-Dependent Kinase Inhibitor p19 * DNA Damage * Enhancer of Zeste Homolog 2 Protein * Female * Histones * Male * Mesenchymal Stem Cells * Mice * Mice, Knockout * Osteocytes * Osteogenesis * Osteoporosis * Oxidative Stress * Receptors, Calcitriol * Vitamin D |keywords=* Ezh2 * Vitamin D * cellular senescence * osteogenesis * osteoporosis * p16 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996957 }} {{medline-entry |title=Active vitamin D impedes the progression of non-alcoholic fatty liver disease by inhibiting cell senescence in a rat model. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31810868 |keywords=* Active vitamin D * Cell senescence * Non-alcoholic fatty liver disease * Oxidative stress * P53-p21 signaling pathway * Vitamin D receptor |full-text-url=https://sci-hub.do/10.1016/j.clinre.2019.10.007 }} ==VEGFA== {{medline-entry |title=APOE ε4-specific associations of VEGF gene family expression with cognitive aging and Alzheimer's disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31791659 |mesh-terms=* Aged * Aged, 80 and over * Aging * Apolipoprotein E4 * Cognitive Aging * Cognitive Dysfunction * Female * Gene Expression * Genetic Association Studies * Genetic Predisposition to Disease * Genotype * Humans * Male * Neovascularization, Physiologic * Neuropilin-1 * Vascular Endothelial Growth Factor A |keywords=* APOE-ε4 * Aging * Cognition * Gene expression * Vascular endothelial growth factor (VEGF) |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064375 }} ==VGLL4== {{medline-entry |title=The lncRNA MEG3/miR-16-5p/[[VGLL4]] regulatory axis is involved in etoposide-induced senescence of tumor cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33141998 |keywords=* LncRNA MEG3 * breast cancer * cell senescence * etoposide * lung adenocarcinoma |full-text-url=https://sci-hub.do/10.1002/jgm.3291 }} ==VHL== {{medline-entry |title=Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a [[VHL]]-1-independent transcriptional response. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32399915 |keywords=* Aging * C. elegans * EGL-9/PHD * HIF-1 signaling * Hypoxic response * Lifespan * RHY-1 |full-text-url=https://sci-hub.do/10.1007/s11357-020-00194-0 }} ==VIM== {{medline-entry |title=Establishment and characterization of a fibroblast cell line from postmortem skin of an adult Chinese muntjac (Muntiacus reevesi). |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31898011 |mesh-terms=* Aging * Animals * Cell Culture Techniques * Cell Line * Cell Proliferation * Cell Shape * Chromosomes, Mammalian * Fibroblasts * Male * Muntjacs * Postmortem Changes * Skin |keywords=* Characteristics * Chinese muntjac * Fibroblast cell line * Postmortem skin |full-text-url=https://sci-hub.do/10.1007/s11626-019-00422-8 }} ==VIP== {{medline-entry |title=Alterations in Intrinsic and Synaptic Properties of Hippocampal CA1 [[VIP]] Interneurons During Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33173468 |keywords=* VIP * action potential * aging * calretinin * circuit disinhibition * hippocampus * synapse |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591401 }} {{medline-entry |title=Nutrition and exercise interventions could ameliorate age-related cognitive decline: a meta-analysis of randomized controlled trials. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33052590 |keywords=* Aging * Cognitive impairment * Exercise * Meta-analysis * Nutrition |full-text-url=https://sci-hub.do/10.1007/s40520-020-01730-w }} ==VSIG4== {{medline-entry |title=Immune checkpoint protein [[VSIG4]] as a biomarker of aging in murine adipose tissue. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32856419 |keywords=* VSIG4 * adipose tissue * aging * frailty index * immune checkpoint * inflammation * macrophage * mouse |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7576241 }} ==WASL== {{medline-entry |title=Loss of Wasl improves pancreatic cancer outcome. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32434991 |keywords=* Cancer * Cellular senescence * Mouse models * Oncology |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259520 }} ==WDR5== {{medline-entry |title=Inhibition of the H3K4 methyltransferase MLL1/[[WDR5]] complex attenuates renal senescence in ischemia reperfusion mice by reduction of p16 . |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31570196 |mesh-terms=* Acute Kidney Injury * Animals * Biphenyl Compounds * Cell Line * Cyclin-Dependent Kinase Inhibitor p16 * Dihydropyridines * Drug Evaluation, Preclinical * Fibroblasts * Histone-Lysine N-Methyltransferase * Histones * Intracellular Signaling Peptides and Proteins * Male * Mice, Inbred C57BL * Myeloid-Lymphoid Leukemia Protein * Rats * Renal Insufficiency * Reperfusion Injury |keywords=* H3K4me3 * MLL1 * WDR5 * acute kidney injury * p16(INK4a) * senescence |full-text-url=https://sci-hub.do/10.1016/j.kint.2019.06.021 }} ==WFDC2== {{medline-entry |title=Differences in biomarkers and molecular pathways according to age for patients with HFrEF. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33002110 |keywords=* aging * biological age * biomarkers * chronological age * heart failure with reduced ejection fraction |full-text-url=https://sci-hub.do/10.1093/cvr/cvaa279 }} ==WIPI2== {{medline-entry |title=Neuronal autophagy declines substantially with age and is rescued by overexpression of [[WIPI2]]. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31794336 |mesh-terms=* Aging * Animals * Autophagy * Autophagy-Related Proteins * Mice, Transgenic * Models, Biological * Neurons * Phagosomes * Phosphate-Binding Proteins * RNA, Messenger |keywords=* Aging * WIPI2 * autophagosome biogenesis * autophagy * macroautophagy * neurodegeneration * neuronal autophagy |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984449 }} ==WNT1== {{medline-entry |title=Plasma proteomic profile of age, health span, and all-cause mortality in older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33089916 |keywords=* SomaScan® assay * aging * proteomics * weighted gene co-expression network analysis |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681045 }} ==WNT10A== {{medline-entry |title=Dysregulation of the Wnt Signaling Pathway and Synovial Stem Cell Dysfunction in Osteoarthritis Development. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31964233 |keywords=* Wnt signaling pathway * cell senescence * differentiation * osteoarthritis * synovial mesenchymal stem cells (SMSCs) |full-text-url=https://sci-hub.do/10.1089/scd.2019.0260 }} ==WNT3A== {{medline-entry |title=Chronic WNT/β-catenin signaling induces cellular senescence in lung epithelial cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32109549 |keywords=* ATII cells * Aging * Cellular senescence * IPF * WNT signaling |full-text-url=https://sci-hub.do/10.1016/j.cellsig.2020.109588 }} ==WNT7A== {{medline-entry |title=Exogenous Expression of [[WNT7A]] in Leukemia-Derived Cell Lines Induces Resistance to Chemotherapeutic Agents. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32436833 |keywords=* WNT signaling * WNT7A * cell cycle * chemotherapeutic agents * leukemias * senescence |full-text-url=https://sci-hub.do/10.2174/1871520620666200521114100 }} ==WRN== {{medline-entry |title=The Impact of Vitamin C on Different System Models of Werner Syndrome. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33202145 |keywords=* Werner syndrome * aging * mouse * stem cells * vitamin C * worm |full-text-url=https://sci-hub.do/10.1089/ars.2020.8147 }} {{medline-entry |title=[[WRN]] modulates translation by influencing nuclear mRNA export in HeLa cancer cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33054770 |keywords=* Cancer * NXF1 export receptor * Senescence * Translation * Werner syndrome protein * mRNA export |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557079 }} {{medline-entry |title=MIB1-mediated degradation of [[WRN]] promotes cellular senescence in response to camptothecin treatment. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32652764 |keywords=* CPT * Mind bomb 1 * Werner syndrome protein * aging * protein stability |full-text-url=https://sci-hub.do/10.1096/fj.202000268RRR }} {{medline-entry |title=A Case Report of Werner's Syndrome With a Novel Mutation From India. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32528764 |keywords=* aging * novel mutation * progeria * werner syndrome * wrn gene |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282380 }} {{medline-entry |title=Evidence for premature aging in a Drosophila model of Werner syndrome. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31518666 |mesh-terms=* Aging, Premature * Animals * Behavior, Animal * Body Composition * Body Weight * DNA Repair * Drosophila * Drosophila Proteins * Exonucleases * Female * Gastrointestinal Neoplasms * Male * Motor Activity * Muscle Weakness * Mutation * Phenotype * Werner Syndrome |keywords=* Aging * DNA repair * Locomotor function * Tumor * Werner syndrome |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935377 }} ==WT1== {{medline-entry |title=Age and weight at first mating affects plasma leptin concentration but no effects on reproductive performance of gilts. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31602307 |keywords=* Backfat * Gilts * Leptin * Litter performance * Longevity * Mating |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778857 }} ==WWP1== {{medline-entry |title=The ubiquitin ligase [[WWP1]] contributes to shifts in matrix proteolytic profiles and a myocardial aging phenotype with diastolic heart. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32822210 |mesh-terms=* Age Factors * Animals * Cells, Cultured * Diastole * Disease Models, Animal * Extracellular Matrix * Female * Fibroblasts * Heart Failure * Hypertrophy, Left Ventricular * Male * Mice, Inbred C57BL * Mice, Transgenic * Myocardium * Phenotype * Proteolysis * Stroke Volume * Ubiquitin-Protein Ligases * Ventricular Dysfunction, Left * Ventricular Function, Left * Ventricular Remodeling |keywords=* aging * cardiac hypertrophy * diastolic dysfunction * heart failure * ventricular remodeling |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717125 }} ==XBP1== {{medline-entry |title=Age-dependent impairment of adipose-derived stem cells isolated from horses. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31900232 |keywords=* Aging * Endoplasmic reticulum stress * Equine adipose-derived mesenchymal stem cells * Insulin resistance * Pro-inflammatory cytokines |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942290 }} ==XDH== {{medline-entry |title=Enhancing xanthine dehydrogenase activity is an effective way to delay leaf senescence and increase rice yield. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32162142 |keywords=* Allantoin * Reactive oxygen species * Rice (Oryza sativa L.) * Senescence * Xanthine dehydrogenase * Yield |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065298 }} ==ZC3H12A== {{medline-entry |title=Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31786670 |mesh-terms=* Aging * Animals * Calgranulin A * Cell Differentiation * Cell Proliferation * Cells, Cultured * Cornified Envelope Proline-Rich Proteins * Epidermis * Gene Expression Regulation * Gene Ontology * Inflammation * Interleukin-1 * Keratinocytes * Keratins * Lymph Nodes * Mice * Mice, Inbred C57BL * Mice, Transgenic * Proliferating Cell Nuclear Antigen * Ribonucleases * Skin * Spleen * Transcriptome |keywords=* MCPIP1 * Regnase-1 * Skin inflammation * ZC3H12A |full-text-url=https://sci-hub.do/10.1007/s00109-019-01853-2 }} ==ZEB2== {{medline-entry |title=miR-200b regulates cellular senescence and inflammatory responses by targeting [[ZEB2]] in pulmonary emphysema. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32070140 |mesh-terms=* Animals * Cell Line * Cellular Senescence * Disease Models, Animal * Gene Expression * Gene Expression Regulation * Inflammation * Lung * Mice * MicroRNAs * Pulmonary Emphysema * Zinc Finger E-box Binding Homeobox 2 |keywords=* ZEB2 * cellular senescence * inflammation * miR-200b * pulmonary emphysema |full-text-url=https://sci-hub.do/10.1080/21691401.2020.1725029 }} ==ZMPSTE24== {{medline-entry |title=Bone marrow-derived mesenchymal stem cells in three-dimensional co-culture attenuate degeneration of nucleus pulposus cells. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31666429 |mesh-terms=* Bone Marrow Cells * Cell Cycle * Cell Proliferation * Cell Survival * Cells, Cultured * Cellular Senescence * Coculture Techniques * Collagen Type II * Female * Humans * Intervertebral Disc Degeneration * Male * Matrix Metalloproteinase 9 * Membrane Proteins * Mesenchymal Stem Cells * Metalloendopeptidases * Middle Aged * Nucleus Pulposus * Signal Transduction * Transcription Factor RelA * Up-Regulation * beta-Galactosidase |keywords=* 3D co-culture * ZMPSTE24 * bone marrow-derived mesenchymal stem cells * nucleus pulposus * senescence |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834418 }}
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