Редактирование: Публикации о генах и старении (titles) (раздел)

==CA1==

{{medline-entry
|title=The relation between tau pathology and granulovacuolar degeneration of neurons.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33069844


|keywords=* AT8
* Aging
* CA1
* Casein kinase 1δ
* Congo red
* Dorsal raphe nucleus
* Locus coeruleus
* Neurodegeneration
* Tau pathology
|full-text-url=https://sci-hub.do/10.1016/j.nbd.2020.105138
}}
{{medline-entry
|title=Memory and dendritic spines loss, and dynamic dendritic spines changes are age-dependent in the rat.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32950615


|keywords=* Aging
* Hippocampus
* Locomotor activity
* Memory and learning
* Prefrontal cortex
* Pyramidal neurons
* dendritic spines
|full-text-url=https://sci-hub.do/10.1016/j.jchemneu.2020.101858
}}
{{medline-entry
|title=Deregulated expression of a longevity gene, Klotho, in the C9orf72 deletion mice with impaired synaptic plasticity and adult hippocampal neurogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32887666


|keywords=* Amyotrophic lateral sclerosis (ALS)
* C9ORF72
* Dentate gyrus, adult neurogenesis
* Frontotemporal dementia (FTD)
* Klotho
* Long-term depression (LTD)
* Long-term potentiation (LTP)
* Longevity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7473815
}}
{{medline-entry
|title=COX5A Plays a Vital Role in Memory Impairment Associated With Brain Aging [i]via[/i] the BDNF/ERK1/2 Signaling Pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32754029


|keywords=* BDNF
* COX5A
* ERK1/2
* brain senescence
* memory impairment
* mitochondria
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365906
}}
{{medline-entry
|title=Changes of fat-mass and obesity-associated protein expression in the hippocampus in animal models of high-fat diet-induced obesity and D-galactose-induced aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32647628


|keywords=* Aging
* Fto
* Hippocampus
* Mice
* Obesity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336480
}}
{{medline-entry
|title=Phenylbutyrate ameliorates prefrontal cortex, hippocampus, and nucleus accumbens neural atrophy as well as synaptophysin and GFAP stress in aging mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32531811


|keywords=* aging
* dendrites
* hippocampus
* memory and learning
* nucleus accumbens
* prefrontal cortex
* sodium phenylbutyrate
|full-text-url=https://sci-hub.do/10.1002/syn.22177
}}
{{medline-entry
|title=Heterogeneity in brain distribution of activated microglia and astrocytes in a rat ischemic model of Alzheimer's disease after 2 years of survival.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32501292


|keywords=* Alzheimer’s disease
* aging
* brain ischemia
* glia
* neuroinflammation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343500
}}
{{medline-entry
|title=Hippocampal Subregion Transcriptomic Profiles Reflect Strategy Selection during Cognitive Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32376783

|mesh-terms=* Animals
* Cognitive Aging
* Dentate Gyrus
* Hippocampus
* Maze Learning
* Rats
* Rats, Inbred F344
* Spatial Memory
* Transcriptome
|keywords=* aging
* hippocampus
* pattern separation
* reference memory
* spatial discrimination
* transcription
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326352
}}
{{medline-entry
|title=Associations between pattern separation and hippocampal subfield structure and function vary along the lifespan: A 7 T imaging study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32371923

|mesh-terms=* Adult
* Age Factors
* Aged
* Brain Mapping
* Female
* Hippocampus
* Humans
* Longevity
* Magnetic Resonance Imaging
* Male
* Middle Aged
* Young Adult

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200747
}}
{{medline-entry
|title=Laminarin Pretreatment Provides Neuroprotection against Forebrain Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Neuroinflammation in Aged Gerbils.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32326571


|keywords=* aging
* laminarin
* neuroinflammation
* neuroprotection
* oxidative stress
* transient cerebral ischemia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230782
}}
{{medline-entry
|title=Age-dependent Alteration in Mitochondrial Dynamics and Autophagy in Hippocampal Neuron of Cannabinoid CB1 Receptor-deficient Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32294520


|keywords=* Aging
* CB1 receptor
* Hippocampus
* Mitochondria
* Mitophagy
|full-text-url=https://sci-hub.do/10.1016/j.brainresbull.2020.03.014
}}
{{medline-entry
|title=Functional Connectivity of Hippocampal CA3 Predicts Neurocognitive Aging via [[CA1]]-Frontal Circuit.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32239141


|keywords=* aging
* functional connectivity
* hippocampus
* spatial memory
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325802
}}
{{medline-entry
|title=Integration of qRT-PCR and Immunohistochemical Techniques for mRNA Expression and Localization of m1AChR in the Brain of Aging Rat.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32219760


|keywords=* Acetylcholine
* Aging
* Brain
* Immunohistochemistry
* m1AChR
* qRT-PCR
|full-text-url=https://sci-hub.do/10.1007/978-1-0716-0471-7_23
}}
{{medline-entry
|title=Role of Eclipta prostrata extract in improving spatial learning and memory deficits in D-galactose-induced aging in rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32186114

|mesh-terms=* Aging
* Animals
* Behavior, Animal
* CA1 Region, Hippocampal
* Catalase
* Dopamine
* Eclipta
* Galactose
* Gene Expression Regulation, Enzymologic
* Glutathione Peroxidase
* Glutathione Reductase
* Male
* Memory Disorders
* Nitric Oxide
* Nitric Oxide Synthase Type II
* Norepinephrine
* Plant Extracts
* RNA, Messenger
* Rats
* Rats, Sprague-Dawley
* Serotonin
* Spatial Learning
* Superoxide Dismutase
|keywords=* Antioxidants
* Eclipta
* Galactose
* Memory disorders
* Spatial learning

}}
{{medline-entry
|title=Differential annualized rates of hippocampal subfields atrophy in aging and future Alzheimer's clinical syndrome.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32107063

|mesh-terms=* Aged
* Aging
* Alzheimer Disease
* Atrophy
* Cohort Studies
* Cross-Sectional Studies
* Dentate Gyrus
* Female
* Hippocampus
* Humans
* Magnetic Resonance Imaging
* Male
* Neuropsychological Tests
* Risk
|keywords=* Aging
* Alzheimer's disease
* Hippocampal subfields
* MRI
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.01.011
}}
{{medline-entry
|title=Rectification of radiotherapy-induced cognitive impairments in aged mice by reconstituted Sca-1  stem cells from young donors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32028989

|mesh-terms=* Animals
* Behavior, Animal
* Cognitive Dysfunction
* Dendritic Spines
* Hematopoietic Stem Cell Transplantation
* Hippocampus
* Humans
* Long-Term Potentiation
* Maze Learning
* Memory
* Mice
* Neurons
* Radiotherapy
* Recovery of Function
* Spinocerebellar Ataxias
* Treatment Outcome
|keywords=* Aging
* Bone marrow stem cells
* Learning and memory
* Microglia
* Radiotherapy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006105
}}
{{medline-entry
|title=Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31919362

|mesh-terms=* Aging
* Animals
* Cyclin D1
* Cyclin-Dependent Kinase 4
* Female
* Hippocampus
* Learning
* Memory
* Memory Consolidation
* Mice
* Mice, Inbred C57BL
* Neural Stem Cells
* Neurogenesis

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952376
}}
{{medline-entry
|title=Memory Performance Correlates of Hippocampal Subfield Volume in Mild Cognitive Impairment Subtype.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31849620


|keywords=* aging
* hippocampus
* memory
* mild cognitive impairment
* neuroimaging
* subfields
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897308
}}
{{medline-entry
|title=Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31873156

|mesh-terms=* Aging
* Animals
* CA3 Region, Hippocampal
* Long-Term Potentiation
* Mice
* Mossy Fibers, Hippocampal
* Spermidine
* Synaptic Transmission
* Synaptic Vesicles

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927957
}}
{{medline-entry
|title=Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31843022

|mesh-terms=* Aging
* Animals
* Caspase 6
* Caspase Inhibitors
* Cognitive Dysfunction
* Female
* Humans
* Inflammation
* Male
* Methylene Blue
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Mice, Transgenic
|keywords=* Alzheimer disease
* Axonal degeneration
* Caspase-6
* Caspase-6 inhibitor
* Hippocampal CA1
* Hippocampal fibres
* Methylene blue
* Synaptic plasticity
* White matter
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915996
}}
{{medline-entry
|title=Long-term Memory Upscales Volume of Postsynaptic Densities in the Process that Requires Autophosphorylation of αCaMKII.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31800021


|keywords=* CA1 area
* CaMKII
* IntelliCages
* aging
* dendritic spines
* memory
* postsynaptic density
|full-text-url=https://sci-hub.do/10.1093/cercor/bhz261
}}
{{medline-entry
|title=PACAP27 mitigates an age-dependent hippocampal vulnerability to PGJ2-induced spatial learning deficits and neuroinflammation in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31769222


|keywords=* CA1
* CA3
* Fluoro-Jade C
* aging
* microglia
* radial arm maze
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955932
}}
{{medline-entry
|title=Inhibition of oxidative stress by testosterone improves synaptic plasticity in senescence accelerated mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31746286

|mesh-terms=* Aging
* Animals
* Male
* Mice
* Neuronal Plasticity
* Oxidative Stress
* Random Allocation
* Receptors, N-Methyl-D-Aspartate
* Testosterone
|keywords=* Alzheimer’s disease
* N-methyl-D-aspartate receptor-1
* Senescence accelerated mouse
* Testosterone
* oxidative stress
|full-text-url=https://sci-hub.do/10.1080/15287394.2019.1683988
}}
{{medline-entry
|title=Restored presynaptic synaptophysin and cholinergic inputs contribute to the protective effects of physical running on spatial memory in aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31470103

|mesh-terms=* Aging
* Animals
* Cholinergic Neurons
* Hippocampus
* Mice
* Mice, Inbred C57BL
* Physical Conditioning, Animal
* Presynaptic Terminals
* Spatial Memory
* Synaptophysin
|keywords=* Aging
* Cholinergic cells
* Hippocampus
* Memory
* Physical training
* Presynaptic terminals
* Synaptophysin
|full-text-url=https://sci-hub.do/10.1016/j.nbd.2019.104586
}}
{{medline-entry
|title=Senescent neurophysiology: Ca  signaling from the membrane to the nucleus.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31394200

|mesh-terms=* Aging
* Animals
* CA1 Region, Hippocampal
* Calcium Signaling
* Cell Nucleus
* Epigenesis, Genetic
* Excitatory Postsynaptic Potentials
* Humans
* Membrane Potentials
* Neuronal Plasticity
* Pyramidal Cells
* Receptors, N-Methyl-D-Aspartate
|keywords=* Afterhyperpolarization
* Aging
* Epigenetics
* Hippocampus
* N-methyl-D-aspartate receptor
* Synaptic plasticity
* Transcription
|full-text-url=https://sci-hub.do/10.1016/j.nlm.2019.107064
}}