Редактирование: Aging genes 100-199 (раздел)

==APP==

* {{medline-title
|title=Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging.
|date=11.09.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32917871
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486940
}}
* {{medline-title
|title=Regorafenib Regulates AD Pathology, Neuroinflammation, and Dendritic Spinogenesis in Cells and a Mouse Model of AD.
|date=09.07.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32660121
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408082
}}
* {{medline-title
|title=An agnostic reevaluation of the amyloid cascade hypothesis of Alzheimer's disease pathogenesis: The role of [[APP]] homeostasis.
|date=11.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32588983
|full-text-url=https://sci-hub.do/10.1002/alz.12124
}}
* {{medline-title
|title=Transcriptomic profiling of microglia and astrocytes throughout aging.
|date=01.04.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32238175
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115095
}}
* {{medline-title
|title=Platelets in Amyloidogenic Mice Are Activated and Invade the Brain.
|date=2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32194368
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063083
}}
* {{medline-title
|title=Disruption of synaptic expression pattern and age-related DNA oxidation in a neuronal model of lead-induced toxicity.
|date=05.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32058320
|full-text-url=https://sci-hub.do/10.1016/j.etap.2020.103350
}}
* {{medline-title
|title=CHIP modulates [[APP]]-induced autophagy-dependent pathological symptoms in Drosophila.
|date=02.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31777182
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996943
}}
* {{medline-title
|title=Studies on [[APP]] metabolism related to age-associated mitochondrial dysfunction in [[APP]]/PS1 transgenic mice.
|date=19.11.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31744937
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914425
}}
* {{medline-title
|title=Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease.
|date=2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31733664
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939615
}}
* {{medline-title
|title=Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer's disease.
|date=31.10.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31673052
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823454
}}
* {{medline-title
|title=Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer's Disease in Patients with Mild Cognitive Impairment: A Pilot Study.
|date=30.10.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31671598
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862463
}}
* {{medline-title
|title=The Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive Dysfunction
|date=03.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31677609
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984714
}}
* {{medline-title
|title=Modulation of Neural and Muscular Adaptation Processes During Resistance Training by Fish Protein Ingestions in Older Adults.
|date=17.04.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31596471
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164534
}}
* {{medline-title
|title=Lifelong choline supplementation ameliorates Alzheimer's disease pathology and associated cognitive deficits by attenuating microglia activation.
|date=12.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31560162
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826123
}}
* {{medline-title
|title=Antipsychotic Polypharmacy in Older Adult Asian Patients With Schizophrenia: Research on Asian Psychotropic Prescription Pattern.
|date=11.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31480982
|full-text-url=https://sci-hub.do/10.1177/0891988719862636
}}
* {{medline-title
|title=A pleiotropic role for exosomes loaded with the amyloid β precursor protein carboxyl-terminal fragments in the brain of Down syndrome patients.
|date=12.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31479861
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960325
}}
* {{medline-title
|title=Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged [[APP]] /PS1  Transgenic Mice.
|date=2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31417357
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682662
}}
* {{medline-title
|title=Systems biology and network pharmacology of frailty reveal novel epigenetic targets and mechanisms.
|date=22.07.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31332237
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646318
}}
* {{medline-title
|title=The Age-Related Performance Decline in Marathon Running: The Paradigm of the Berlin Marathon.
|date=06.06.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31174325
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603944
}}
* {{medline-title
|title=The db mutation improves memory in younger mice in a model of Alzheimer's disease.
|date=01.09.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31034991
|full-text-url=https://sci-hub.do/10.1016/j.bbadis.2019.04.013
}}
* {{medline-title
|title=Electrophysiological Characterization of Networks and Single Cells in the Hippocampal Region of a Transgenic Rat Model of Alzheimer's Disease.
|date=01-02.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30809590
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390198
}}
* {{medline-title
|title=Age- and sex-dependent profiles of [[APP]] fragments and key secretases align with changes in despair-like behavior and cognition in young [[APP]]Swe/Ind mice.
|date=02.04.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30803762
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2019.02.083
}}
* {{medline-title
|title=Upregulation of Proteolytic Pathways and Altered Protein Biosynthesis Underlie Retinal Pathology in a Mouse Model of Alzheimer's Disease.
|date=09.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30707393
|full-text-url=https://sci-hub.do/10.1007/s12035-019-1479-4
}}
* {{medline-title
|title=Soluble Amyloid Precursor Protein α: Friend or Foe?
|date=2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30637698
|full-text-url=https://sci-hub.do/10.1007/978-981-13-3065-0_13
}}
* {{medline-title
|title=Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity.
|date=08.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30612335
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6614131
}}
* {{medline-title
|title=Selective reduction of [[APP]]-[[BACE1]] activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PD[[APP]] mice.
|date=03.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30572184
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357873
}}
* {{medline-title
|title=Effect of Resistance Training and Fish Protein Intake on Motor Unit Firing Pattern and Motor Function of Elderly.
|date=2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30564141
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288440
}}
* {{medline-title
|title=The amyloid precursor protein ([[APP]]) processing as a biological link between Alzheimer's disease and cancer.
|date=01.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30500566
|full-text-url=https://sci-hub.do/10.1016/j.arr.2018.11.007
}}
* {{medline-title
|title=Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study.
|date=06.11.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30400912
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220478
}}
* {{medline-title
|title=Analysis of Motor Function in Amyloid Precursor-Like Protein 2 Knockout Mice: The Effects of Ageing and Sex.
|date=06.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30362021
|full-text-url=https://sci-hub.do/10.1007/s11064-018-2669-6
}}
* {{medline-title
|title=Increased Insoluble Amyloid-β Induces Negligible Cognitive Deficits in Old AppNL/NL Knock-In Mice.
|date=2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30320577
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218137
}}
* {{medline-title
|title=Long-term dietary supplementation with the green tea cultivar Sunrouge prevents age-related cognitive decline in the senescence-accelerated mouse Prone8.
|date=02.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30295144
|full-text-url=https://sci-hub.do/10.1080/09168451.2018.1530093
}}
* {{medline-title
|title=Axonal organization defects in the hippocampus of adult conditional [[BACE1]] knockout mice.
|date=19.09.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30232227
|full-text-url=https://sci-hub.do/10.1126/scitranslmed.aao5620
}}
* {{medline-title
|title=The age of peak performance in women and men duathletes - The paradigm of short and long versions in "Powerman Zofingen".
|date=2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30140162
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054758
}}
* {{medline-title
|title=Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice.
|date=10.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30112699
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277293
}}
* {{medline-title
|title=Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases.
|date=11.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30071357
|full-text-url=https://sci-hub.do/10.1016/j.arr.2018.07.004
}}
* {{medline-title
|title=DNA methylation analysis on purified neurons and glia dissects age and Alzheimer's disease-specific changes in the human cortex.
|date=25.07.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30045751
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058387
}}
* {{medline-title
|title=Alterations of functional circuitry in aging brain and the impact of mutated [[APP]] expression.
|date=10.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30055413
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159914
}}
* {{medline-title
|title=Menadione sodium bisulfite inhibits the toxic aggregation of amyloid-β(1-42).
|date=10.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30036601
|full-text-url=https://sci-hub.do/10.1016/j.bbagen.2018.07.019
}}
* {{medline-title
|title=Sirtuin 1 and Alzheimer's disease: An up-to-date review.
|date=10.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30007474
|full-text-url=https://sci-hub.do/10.1016/j.npep.2018.07.001
}}
* {{medline-title
|title=Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease.
|date=10.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29981845
|full-text-url=https://sci-hub.do/10.1016/j.bbadis.2018.07.005
}}
* {{medline-title
|title=Human Cord Blood Serum-Derived [[APP]] α-Secretase Cleavage Activity is Mediated by C1 Complement.
|date=04.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29871524
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020233
}}
* {{medline-title
|title=Interaction between a [[MAPT]] variant causing frontotemporal dementia and mutant [[APP]] affects axonal transport.
|date=08.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29729423
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998378
}}
* {{medline-title
|title=Blood-Brain Barrier Disruption and Perivascular Beta-Amyloid Accumulation in the Brain of Aged Rats with Spontaneous Hypertension: Evaluation with Dynamic Contrast-Enhanced Magnetic Resonance Imaging.
|date=05-06.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29713228
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904477
}}
* {{medline-title
|title=Drosophila Full-Length Amyloid Precursor Protein Is Required for Visual Working Memory and Prevents Age-Related Memory Impairment.
|date=05.03.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29478851
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840017
}}
* {{medline-title
|title=β-amyloid expression in age-related cataract lens epithelia and the effect of β-amyloid on oxidative damage in human lens epithelial cells.
|date=2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29386875
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757856
}}
* {{medline-title
|title=Effects of senescence and angiotensin II on expression and processing of amyloid precursor protein in human cerebral microvascular endothelial cells.
|date=15.01.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29348391
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811245
}}
* {{medline-title
|title=Disturbances in the control of capillary flow in an aged [[APP]] /PS1ΔE9 model of Alzheimer's disease.
|date=02.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29131981
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2017.10.006
}}
* {{medline-title
|title=Istradefylline reduces memory deficits in aging mice with amyloid pathology.
|date=02.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29100987
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747997
}}
* {{medline-title
|title=The age-related slow increase in amyloid pathology in [[APP]].V717I mice activates microglia, but does not alter hippocampal neurogenesis.
|date=01.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29059594
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2017.09.013
}}
* {{medline-title
|title=Sortilin inhibits amyloid pathology by regulating non-specific degradation of [[APP]].
|date=01.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29056359
|full-text-url=https://sci-hub.do/10.1016/j.expneurol.2017.10.018
}}
* {{medline-title
|title=Differential deregulation of [[NGF]] and [[BDNF]] neurotrophins in a transgenic rat model of Alzheimer's disease.
|date=12.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28865749
|full-text-url=https://sci-hub.do/10.1016/j.nbd.2017.08.019
}}
* {{medline-title
|title=Analyzing Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activation in Aging and Vascular Amyloid Pathology.
|date=2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28824611
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534478
}}
* {{medline-title
|title=Oligomeric amyloid-beta induces MAPK-mediated activation of brain cytosolic and calcium-independent phospholipase A  in a spatial-specific manner.
|date=27.07.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28750656
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530945
}}
* {{medline-title
|title=Proteins Involved in Endocytosis Are Upregulated by Ageing in the Normal Human Brain: Implications for the Development of Alzheimer's Disease.
|date=02.03.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28655199
|full-text-url=https://sci-hub.do/10.1093/gerona/glx135
}}
* {{medline-title
|title=Normalizing the gene dosage of Dyrk1A in a mouse model of Down syndrome rescues several Alzheimer's disease phenotypes.
|date=10.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28647555
|full-text-url=https://sci-hub.do/10.1016/j.nbd.2017.06.010
}}
* {{medline-title
|title=Effective expression of Drebrin in hippocampus improves cognitive function and alleviates lesions of Alzheimer's disease in [[APP]] (swe)/PS1 (ΔE9) mice.
|date=07.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28597477
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492767
}}
* {{medline-title
|title=Neuronal tetraploidization in the cerebral cortex correlates with reduced cognition in mice and precedes and recapitulates Alzheimer's-associated neuropathology.
|date=08.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28494436
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2017.04.008
}}
* {{medline-title
|title=Neuron and neuroblast numbers and cytogenesis in the dentate gyrus of aged [[APP]] /PS1  transgenic mice: Effect of long-term treatment with paroxetine.
|date=08.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28461249
|full-text-url=https://sci-hub.do/10.1016/j.nbd.2017.04.021
}}
* {{medline-title
|title=Amyloid precursor protein, lipofuscin accumulation and expression of autophagy markers in aged bovine brain.
|date=13.04.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28407771
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390414
}}
* {{medline-title
|title=Effects of vitamin D and resveratrol on metabolic associated markers in liver and adipose tissue from SAMP8 mice.
|date=07.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28411010
|full-text-url=https://sci-hub.do/10.1016/j.exger.2017.03.017
}}
* {{medline-title
|title=Effect of aging and Alzheimer's disease-like pathology on brain monoamines in mice.
|date=09.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28414094
|full-text-url=https://sci-hub.do/10.1016/j.neuint.2017.04.008
}}
* {{medline-title
|title=Regulation of Alpha-Secretase [[ADAM10]] [i]In vitro[/i] and [i]In vivo[/i]: Genetic, Epigenetic, and Protein-Based Mechanisms.
|date=2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28367112
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355436
}}
* {{medline-title
|title=Knockdown of [[APP]]L mimics transgenic Aβ induced neurodegenerative phenotypes in Drosophila.
|date=01.05.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28336338
|full-text-url=https://sci-hub.do/10.1016/j.neulet.2017.03.030
}}
* {{medline-title
|title=Nonamyloidogenic processing of amyloid beta precursor protein is associated with retinal function improvement in aging male [[APP]] /PS1ΔE9 mice.
|date=05.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28262325
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2017.02.004
}}
* {{medline-title
|title=Cerebrospinal fluid biomarkers of infantile congenital hydrocephalus.
|date=2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28212403
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315300
}}
* {{medline-title
|title=[[APP]] Deletion Accounts for Age-Dependent Changes in the Bioenergetic Metabolism and in Hyperphosphorylated CaMKII at Stimulated Hippocampal Presynaptic Active Zones.
|date=2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28163681
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247443
}}
* {{medline-title
|title=Mid-life environmental enrichment increases synaptic density in [[CA1]] in a mouse model of Aβ-associated pathology and positively influences synaptic and cognitive health in healthy ageing.
|date=01.06.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27987205
|full-text-url=https://sci-hub.do/10.1002/cne.24156
}}
* {{medline-title
|title=Copper accumulation in rodent brain astrocytes: A species difference.
|date=01.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27908425
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141684
}}
* {{medline-title
|title=The Effects of Peripheral and Central High Insulin on Brain Insulin Signaling and Amyloid-β in Young and Old [[APP]]/PS1 Mice.
|date=16.11.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27852778
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125227
}}
* {{medline-title
|title=Disordered [[APP]] metabolism and neurovasculature in trauma and aging: Combined risks for chronic neurodegenerative disorders.
|date=03.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27829172
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315701
}}
* {{medline-title
|title=Prevention of tau increase in cerebrospinal fluid of [[APP]] transgenic mice suggests downstream effect of [[BACE1]] inhibition.
|date=06.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27750032
|full-text-url=https://sci-hub.do/10.1016/j.jalz.2016.09.005
}}
* {{medline-title
|title=Aging process alters hippocampal and cortical secretase activities of Wistar rats.
|date=15.01.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27702637
|full-text-url=https://sci-hub.do/10.1016/j.bbr.2016.09.066
}}
* {{medline-title
|title=Alzheimer-related protein APL-1 modulates lifespan through heterochronic gene regulation in Caenorhabditis elegans.
|date=12.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27557896
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114704
}}
* {{medline-title
|title=Neuroprotective properties of mitochondria-targeted antioxidants of the SkQ-type.
|date=01.12.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27559690
|full-text-url=https://sci-hub.do/10.1515/revneuro-2016-0036
}}
* {{medline-title
|title=Relation of size of seminal vesicles on ultrasound to premature ejaculation.
|date=09-10.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27538475
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566849
}}
* {{medline-title
|title=Restoring Soluble Amyloid Precursor Protein α Functions as a Potential Treatment for Alzheimer's Disease.
|date=04.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27531392
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296245
}}
* {{medline-title
|title=Fuzhisan Ameliorates the Memory Deficits in Aged SAMP8 Mice via Decreasing Aβ Production and Tau Hyperphosphorylation of the Hippocampus.
|date=11.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27518086
|full-text-url=https://sci-hub.do/10.1007/s11064-016-2028-4
}}
* {{medline-title
|title=Hydroxytyrosol mildly improve cognitive function independent of [[APP]] processing in [[APP]]/PS1 mice.
|date=11.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27287957
|full-text-url=https://sci-hub.do/10.1002/mnfr.201600332
}}
* {{medline-title
|title=Sideritis spp. Extracts Enhance Memory and Learning in Alzheimer's β-Amyloidosis Mouse Models and Aged C57Bl/6 Mice.
|date=31.05.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27258424
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981905
}}
* {{medline-title
|title=Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics.
|date=08.06.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27267879
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897877
}}
* {{medline-title
|title=Genome-wide alteration of 5-hydroxymenthylcytosine in a mouse model of Alzheimer's disease.
|date=20.05.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27207465
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875608
}}
* {{medline-title
|title=Dynein Dysfunction Reproduces Age-Dependent Retromer Deficiency: Concomitant Disruption of Retrograde Trafficking Is Required for Alteration in β-Amyloid Precursor Protein Metabolism.
|date=07.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27179390
|full-text-url=https://sci-hub.do/10.1016/j.ajpath.2016.03.006
}}
* {{medline-title
|title=Possible role of metal ionophore against zinc induced cognitive dysfunction in D-galactose senescent mice.
|date=06.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26923568
|full-text-url=https://sci-hub.do/10.1007/s10534-016-9922-8
}}
* {{medline-title
|title=Partial [[BACE1]] reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of [[APP]]-CTF.
|date=03.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26923405
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773919
}}
* {{medline-title
|title=Alzheimer's disease-like [[APP]] processing in wild-type mice identifies synaptic defects as initial steps of disease progression.
|date=12.01.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26759118
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709894
}}
* {{medline-title
|title=Overexpression of Swedish mutant [[APP]] in aged astrocytes attenuates excitatory synaptic transmission.
|date=01.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26733247
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760399
}}
* {{medline-title
|title=Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease.
|date=09.11.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26549211
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659940
}}
* {{medline-title
|title=Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophila models of Alzheimer's disease.
|date=04.11.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26530776
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632086
}}
* {{medline-title
|title=Caspase-dependent degradation of MDMx/MDM4 cell cycle regulatory protein in amyloid β-induced neuronal damage.
|date=16.11.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26477779
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679561
}}
* {{medline-title
|title=Multiple mechanisms of age-dependent accumulation of amyloid beta protein in rat brain: Prevention by dietary supplementation with N-acetylcysteine, α-lipoic acid and α-tocopherol.
|date=05.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26463138
|full-text-url=https://sci-hub.do/10.1016/j.neuint.2015.10.003
}}
* {{medline-title
|title=Chronic alpha-linolenic acid treatment alleviates age-associated neuropathology: Roles of PERK/eIF2α signaling pathway.
|date=10.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26399745
|full-text-url=https://sci-hub.do/10.1016/j.bbi.2015.09.012
}}
* {{medline-title
|title=Differential interaction of Apolipoprotein-E isoforms with insulin receptors modulates brain insulin signaling in mutant human amyloid precursor protein transgenic mice.
|date=08.09.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26346625
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561911
}}
* {{medline-title
|title=Age- and Sex-Associated Effects on Acute-Phase Proteins in Göttingen Minipigs.
|date=08.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26310463
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549679
}}
* {{medline-title
|title=Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau.
|date=10.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26260389
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604188
}}
* {{medline-title
|title=Nilotinib and bosutinib modulate pre-plaque alterations of blood immune markers and neuro-inflammation in Alzheimer's disease models.
|date=24.09.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26235435
|full-text-url=https://sci-hub.do/10.1016/j.neuroscience.2015.07.070
}}
* {{medline-title
|title=The [[APP]] A673T frequency differs between Nordic countries.
|date=10.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26239177
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562869
}}
* {{medline-title
|title=GSK3β Interactions with Amyloid Genes: An Autopsy Verification and Extension.
|date=10.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26194614
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625986
}}
* {{medline-title
|title=The amyloid precursor protein ([[APP]]) intracellular domain regulates translation of p44, a short isoform of p53, through an IRES-dependent mechanism.
|date=10.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26174856
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562799
}}
* {{medline-title
|title=[[SNX15]] Regulates Cell Surface Recycling of [[APP]] and Aβ Generation.
|date=08.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26115702
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691577
}}
* {{medline-title
|title=DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease.
|date=2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25933409
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416920
}}
* {{medline-title
|title=Manipulations of amyloid precursor protein cleavage disrupt the circadian clock in aging Drosophila.
|date=05.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25766673
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402283
}}
* {{medline-title
|title=Gr33a modulates Drosophila male courtship preference.
|date=14.01.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25586066
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648378
}}
* {{medline-title
|title=Intraventricular human immunoglobulin distributes extensively but fails to modify amyloid in a mouse model of amyloid deposition.
|date=2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25115543
|full-text-url=https://sci-hub.do/10.2174/1567205011666140812114341
}}
* {{medline-title
|title=Omega-3 polyunsaturated fatty acids improve mitochondrial dysfunction in brain aging--impact of Bcl-2 and NPD-1 like metabolites.
|date=01.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24972878
|full-text-url=https://sci-hub.do/10.1016/j.plefa.2014.05.008
}}
* {{medline-title
|title=Enhanced defense against mitochondrial hydrogen peroxide attenuates age-associated cognition decline.
|date=11.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24906890
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2014.05.007
}}
* {{medline-title
|title=Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the [[APP]]/Ld transgenic mouse model of Alzheimer's disease.
|date=02.05.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24885175
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028006
}}
* {{medline-title
|title=Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of β-amyloid by cells other than excitatory neurons.
|date=05.03.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24599465
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942582
}}
* {{medline-title
|title=[[GRK5]] dysfunction accelerates tau hyperphosphorylation in [[APP]] (swe) mice through impaired cholinergic activity.
|date=07.05.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24598771
|full-text-url=https://sci-hub.do/10.1097/WNR.0000000000000142
}}
* {{medline-title
|title=Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer's disease Drosophila models.
|date=05.03.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24597901
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946151
}}
* {{medline-title
|title=Age-dependent effects of valproic acid in Alzheimer's disease (AD) mice are associated with nerve growth factor ([[NGF]]) regulation.
|date=25.04.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24568732
|full-text-url=https://sci-hub.do/10.1016/j.neuroscience.2014.02.012
}}
* {{medline-title
|title=Lessons from a [[BACE1]] inhibitor trial: off-site but not off base.
|date=10.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24530026
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205206
}}
* {{medline-title
|title=A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly.
|date=12.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24535457
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418478
}}
* {{medline-title
|title=Early and sustained altered expression of aging-related genes in young 3xTg-AD mice.
|date=13.02.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24525730
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944230
}}
* {{medline-title
|title=Mitochondrial oxygen consumption deficits in skeletal muscle isolated from an Alzheimer's disease-relevant murine model.
|date=13.02.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24524276
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930757
}}
* {{medline-title
|title=Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease.
|date=04.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24440055
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072239
}}
* {{medline-title
|title=Combined deletions of amyloid precursor protein and amyloid precursor-like protein 2 reveal different effects on mouse brain metal homeostasis.
|date=03.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24448592
|full-text-url=https://sci-hub.do/10.1039/c3mt00358b
}}
* {{medline-title
|title=Expression of amyloid-associated miRNAs in both the forebrain cortex and hippocampus of middle-aged rat.
|date=2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24401368
|full-text-url=https://sci-hub.do/10.1159/000356646
}}
* {{medline-title
|title=MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 ([[BACE1]]) in human primary brain cultures and is reduced in brain tissue specimens of Alzheimer disease subjects.
|date=21.02.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24352696
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931075
}}
* {{medline-title
|title=The effects of dietary restriction and aging on amyloid precursor protein and presenilin-1 mRNA and protein expression in rat brain.
|date=16.04.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24346258
|full-text-url=https://sci-hub.do/10.1097/WNR.0000000000000107
}}
* {{medline-title
|title=Rheb GTPase regulates β-secretase levels and amyloid β generation.
|date=28.02.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24368770
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937651
}}
* {{medline-title
|title=The type of Aβ-related neuronal degeneration differs between amyloid precursor protein ([[APP]]23) and amyloid β-peptide ([[APP]]48) transgenic mice.
|date=18.11.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24252227
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046770
}}
* {{medline-title
|title=The airbag problem-a potential culprit for bench-to-bedside translational efforts: relevance for Alzheimer's disease.
|date=23.09.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24252346
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893418
}}
* {{medline-title
|title=[[BIN1]] is decreased in sporadic but not familial Alzheimer's disease or in aging.
|date=2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24205320
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804620
}}
* {{medline-title
|title=Absence of A673T variant in [[APP]] gene indicates an alternative protective mechanism contributing to longevity in Chinese individuals.
|date=04.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24126161
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2013.09.023
}}
* {{medline-title
|title=The Alzheimer's disease mitochondrial cascade hypothesis: progress and perspectives.
|date=08.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24071439
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962811
}}
* {{medline-title
|title=Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged [[APP]]/PS1 mice, a model of Alzheimer's disease.
|date=01.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23973293
|full-text-url=https://sci-hub.do/10.1016/j.neuropharm.2013.08.005
}}
* {{medline-title
|title=Synergistic effects of hypertension and aging on cognitive function and hippocampal expression of genes involved in β-amyloid generation and Alzheimer's disease.
|date=15.10.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23955715
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798788
}}
* {{medline-title
|title=Changes in amyloid-β and Tau in the cerebrospinal fluid of transgenic mice overexpressing amyloid precursor protein.
|date=17.07.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23863834
|full-text-url=https://sci-hub.do/10.1126/scitranslmed.3006446
}}
* {{medline-title
|title=Antisense directed against PS-1 gene decreases brain oxidative markers in aged senescence accelerated mice (SAMP8) and reverses learning and memory impairment: a proteomics study.
|date=12.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23777706
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855183
}}
* {{medline-title
|title=Swedish mutant [[APP]] suppresses osteoblast differentiation and causes osteoporotic deficit, which are ameliorated by N-acetyl-L-cysteine.
|date=10.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23649480
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104794
}}
* {{medline-title
|title=Non-invasive infra-red therapy (1072 nm) reduces β-amyloid protein levels in the brain of an Alzheimer's disease mouse model, TASTPM.
|date=05.06.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23603448
|full-text-url=https://sci-hub.do/10.1016/j.jphotobiol.2013.02.015
}}
* {{medline-title
|title=The retinoic acid receptor agonist Am80 increases hippocampal [[ADAM10]] in aged SAMP8 mice.
|date=09.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23624141
|full-text-url=https://sci-hub.do/10.1016/j.neuropharm.2013.04.009
}}
* {{medline-title
|title=Spatial learning impairments in PLB1Triple knock-in Alzheimer mice are task-specific and age-dependent.
|date=07.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23535719
|full-text-url=https://sci-hub.do/10.1007/s00018-013-1314-4
}}
* {{medline-title
|title=The senescence hypothesis of disease progression in Alzheimer disease: an integrated matrix of disease pathways for FAD and SAD.
|date=12.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23546742
|full-text-url=https://sci-hub.do/10.1007/s12035-013-8445-3
}}
* {{medline-title
|title=Aβ43 is the earliest-depositing Aβ species in [[APP]] transgenic mouse brain and is converted to Aβ41 by two active domains of [[ACE]].
|date=06.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23562443
|full-text-url=https://sci-hub.do/10.1016/j.ajpath.2013.01.053
}}
* {{medline-title
|title=Regional differences in the morphological and functional effects of aging on cerebral basement membranes and perivascular drainage of amyloid-β from the mouse brain.
|date=04.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23413811
|full-text-url=https://sci-hub.do/10.1111/acel.12045
}}
* {{medline-title
|title=Identification of biomarkers of human skin ageing in both genders. Wnt signalling - a label of skin ageing?
|date=2012
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23226273
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511529
}}
* {{medline-title
|title=Alzheimer's disease.
|date=2012
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23225010
|full-text-url=https://sci-hub.do/10.1007/978-94-007-5416-4_14
}}