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Aging genes 60-99
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==SIRT3== * {{medline-title |title=[[SIRT3]] protects endothelial cells from high glucose-induced senescence and dysfunction via the p53 pathway. |date=05.11.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33160987 |full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118724 }} * {{medline-title |title=Melatonin and Sirtuins in Buccal Epithelium: Potential Biomarkers of Aging and Age-Related Pathologies. |date=30.10.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143333 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662974 }} * {{medline-title |title=[i][[SIRT3]][/i] Transfection of Aged Human Bone Marrow-Derived Mesenchymal Stem Cells Improves Cell Therapy-Mediated Myocardial Repair. |date=28.04.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32228121 |full-text-url=https://sci-hub.do/10.1089/rej.2019.2260 }} * {{medline-title |title=17β-estradiol inhibits H O -induced senescence in HUVEC cells through upregulating [[SIRT3]] expression and promoting autophagy. |date=10.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32172411 |full-text-url=https://sci-hub.do/10.1007/s10522-020-09868-w }} * {{medline-title |title=CR6 interacting factor 1 deficiency induces premature senescence via [[SIRT3]] inhibition in endothelial cells. |date=04.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32109515 |full-text-url=https://sci-hub.do/10.1016/j.freeradbiomed.2020.02.017 }} * {{medline-title |title=Mitochondrial function in skeletal myofibers is controlled by a TRF2-[[SIRT3]] axis over lifetime. |date=03.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31991048 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059141 }} * {{medline-title |title=Context-Dependent Roles for SIRT2 and [[SIRT3]] in Tumor Development Upon Calorie Restriction or High Fat Diet. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31970087 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960403 }} * {{medline-title |title=The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders. |date=01.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31740222 |full-text-url=https://sci-hub.do/10.1016/j.arr.2019.100983 }} * {{medline-title |title=[i]Sirt3[/i] Deficiency Shortens Life Span and Impairs Cardiac Mitochondrial Function Rescued by [i]Opa1[/i] Gene Transfer. |date=12.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31269804 |full-text-url=https://sci-hub.do/10.1089/ars.2018.7703 }} * {{medline-title |title=Low-Dose Pesticide Mixture Induces Accelerated Mesenchymal Stem Cell Aging In Vitro. |date=08.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30977188 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850038 }} * {{medline-title |title=[[NLRP3]]/IL1β inflammasome associated with the aging bladder triggers bladder dysfunction in female rats. |date=04.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30720125 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423574 }} * {{medline-title |title=Targeted Mitochondrial COQ Delivery Attenuates Antiretroviral-Drug-Induced Senescence of Neural Progenitor Cells. |date=04.02.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30592424 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364271 }} * {{medline-title |title=Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy. |date=2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30555576 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276298 }} * {{medline-title |title=The pathophysiological importance and therapeutic potential of NAD' biosynthesis and mitochondrial sirtuin [[SIRT3]] in age-associated diseases. |date=09.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30557475 }} * {{medline-title |title=Aging-Related Overactivity of the Angiotensin/AT1 Axis Decreases Sirtuin 3 Levels in the Substantia Nigra, Which Induces Vulnerability to Oxidative Stress and Neurodegeneration. |date=14.02.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30412227 |full-text-url=https://sci-hub.do/10.1093/gerona/gly259 }} * {{medline-title |title=6-gingerol ameliorates age-related hepatic steatosis: Association with regulating lipogenesis, fatty acid oxidation, oxidative stress and mitochondrial dysfunction. |date=01.01.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30408433 |full-text-url=https://sci-hub.do/10.1016/j.taap.2018.11.001 }} * {{medline-title |title=Sirtuins and NAD in the Development and Treatment of Metabolic and Cardiovascular Diseases. |date=14.09.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30355082 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206880 }} * {{medline-title |title=Moderate calorie restriction attenuates age‑associated alterations and improves cardiac function by increasing [[SIRT1]] and [[SIRT3]] expression. |date=10.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30132522 |full-text-url=https://sci-hub.do/10.3892/mmr.2018.9390 }} * {{medline-title |title=Melatonin Mitigates Mitochondrial Meltdown: Interactions with [[SIRT3]]. |date=18.08.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30126181 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121285 }} * {{medline-title |title=Master athletes have higher miR-7, [[SIRT3]] and [[SOD2]] expression in skeletal muscle than age-matched sedentary controls. |date=10.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30107294 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092475 }} * {{medline-title |title=Sirtuin3 protects aged human mesenchymal stem cells against oxidative stress and enhances efficacy of cell therapy for ischaemic heart diseases. |date=11.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30091830 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201360 }} * {{medline-title |title=Sirtuins in Renal Health and Disease. |date=07.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29712732 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050939 }} * {{medline-title |title=Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14. |date=08.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29654651 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052469 }} * {{medline-title |title=Physical Exercise Improves Aging-Related Changes in Angiotensin, IGF-1, [[SIRT1]], [[SIRT3]], and VEGF in the Substantia Nigra. |date=10.11.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29659739 |full-text-url=https://sci-hub.do/10.1093/gerona/gly072 }} * {{medline-title |title=Differential gene expression of sirtuins between somatotropinomas and nonfunctioning pituitary adenomas. |date=08.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29564694 |full-text-url=https://sci-hub.do/10.1007/s11102-018-0881-7 }} * {{medline-title |title=NAD supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. |date=20.02.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29432159 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828618 }} * {{medline-title |title=Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: Relevance in age-associated vascular dysfunction. |date=04.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29366775 |full-text-url=https://sci-hub.do/10.1016/j.bbadis.2018.01.018 }} * {{medline-title |title=Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of [[SIRT3]]. |date=10.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29289557 |full-text-url=https://sci-hub.do/10.1016/j.mad.2017.12.005 }} * {{medline-title |title=Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress. |date=01.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29063982 |full-text-url=https://sci-hub.do/10.1007/s10571-017-0557-2 }} * {{medline-title |title=[Protective effect of total saponins of Panax notoginseng combined with total flavonoids of epimedium on D-galactose-incuced senescence of H9c2 cell]. |date=02.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28952264 |full-text-url=https://sci-hub.do/10.19540/j.cnki.cjcmm.2017.0012 }} * {{medline-title |title=Obesity and aging diminish sirtuin 1 ([[SIRT1]])-mediated deacetylation of [[SIRT3]], leading to hyperacetylation and decreased activity and stability of [[SIRT3]]. |date=20.10.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28808064 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5655509 }} * {{medline-title |title=miR-34a and miR-9 are overexpressed and SIRT genes are downregulated in peripheral blood mononuclear cells of aging humans. |date=08.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28699360 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5544174 }} * {{medline-title |title=EphB2 signaling-mediated Sirt3 expression reduces [[MSC]] senescence by maintaining mitochondrial ROS homeostasis. |date=09.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28687409 |full-text-url=https://sci-hub.do/10.1016/j.freeradbiomed.2017.07.001 }} * {{medline-title |title=Upregulation of mitochondrial NAD levels impairs the clonogenicity of SSEA1 glioblastoma tumor-initiating cells. |date=09.06.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28604662 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519015 }} * {{medline-title |title=Identification of tissue-specific transcriptional markers of caloric restriction in the mouse and their use to evaluate caloric restriction mimetics. |date=08.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28556428 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506434 }} * {{medline-title |title=Longevity and healthy ageing genes FOXO3A and [[SIRT3]]: Serum protein marker and new road map to burst oxidative stress by Withania somnifera. |date=09.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28526626 |full-text-url=https://sci-hub.do/10.1016/j.exger.2017.05.013 }} * {{medline-title |title=Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts. |date=01.06.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28385812 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495944 }} * {{medline-title |title=Mitochondrial Sirtuins and Molecular Mechanisms of Aging. |date=04.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28285806 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713479 }} * {{medline-title |title=Melatonin and sirtuins: A "not-so unexpected" relationship. |date=03.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28109165 |full-text-url=https://sci-hub.do/10.1111/jpi.12391 }} * {{medline-title |title=[[SIRT3]] mediates decrease of oxidative damage and prevention of ageing in porcine fetal fibroblasts. |date=15.05.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28131761 |full-text-url=https://sci-hub.do/10.1016/j.lfs.2017.01.010 }} * {{medline-title |title=The Role of Mitochondrial Non-Enzymatic Protein Acylation in Ageing. |date=2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28033361 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199114 }} * {{medline-title |title=Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice. |date=12.10.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27731402 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059725 }} * {{medline-title |title=Gardenia jasminoides extract-capped gold nanoparticles reverse hydrogen peroxide-induced premature senescence. |date=11.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27693841 |full-text-url=https://sci-hub.do/10.1016/j.jphotobiol.2016.09.033 }} * {{medline-title |title=Function of the [[SIRT3]] mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease. |date=02.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27686535 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242307 }} * {{medline-title |title=Sirtuin 3 Deregulation Promotes Pulmonary Fibrosis. |date=01.05.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27522058 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964739 }} * {{medline-title |title=Effects of Grape Skin Extract on Age-Related Mitochondrial Dysfunction, Memory and Life Span in C57BL/6J Mice. |date=09.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27455862 |full-text-url=https://sci-hub.do/10.1007/s12017-016-8428-4 }} * {{medline-title |title=Restoration of Mitochondrial NAD Levels Delays Stem Cell Senescence and Facilitates Reprogramming of Aged Somatic Cells. |date=12.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27428041 |full-text-url=https://sci-hub.do/10.1002/stem.2460 }} * {{medline-title |title=Mitochondrial Sirtuin 3 and Renal Diseases. |date=2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27362524 |full-text-url=https://sci-hub.do/10.1159/000444370 }} * {{medline-title |title=[[CD38]] Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an [[SIRT3]]-Dependent Mechanism. |date=14.06.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27304511 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911708 }} * {{medline-title |title=The role of mitochondrial sirtuins in health and disease. |date=11.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27164052 |full-text-url=https://sci-hub.do/10.1016/j.freeradbiomed.2016.04.197 }} * {{medline-title |title=Effects of intrinsic aerobic capacity, aging and voluntary running on skeletal muscle sirtuins and heat shock proteins. |date=15.06.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27038700 |full-text-url=https://sci-hub.do/10.1016/j.exger.2016.03.015 }} * {{medline-title |title=Manganese Superoxide Dismutase Acetylation and Dysregulation, Due to Loss of [[SIRT3]] Activity, Promote a Luminal B-Like Breast Carcinogenic-Permissive Phenotype. |date=20.08.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26935174 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991597 }} * {{medline-title |title=Sirtuins, Cell Senescence, and Vascular Aging. |date=05.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26948035 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848124 }} * {{medline-title |title=[[SIRT3]] Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3β. |date=14.12.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26667039 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760222 }} * {{medline-title |title=The expression levels of the sirtuins in patients with BCC. |date=05.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26631040 |full-text-url=https://sci-hub.do/10.1007/s13277-015-4522-8 }} * {{medline-title |title=Effects of Aging and Cardiovascular Disease Risk Factors on the Expression of Sirtuins in the Human Corpus Cavernosum. |date=11.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26556180 |full-text-url=https://sci-hub.do/10.1111/jsm.13035 }} * {{medline-title |title=Localization of sirtuins ([[SIRT1]]-7) in the aged mouse inner ear. |date=2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26472659 |full-text-url=https://sci-hub.do/10.3109/00016489.2015.1093172 }} * {{medline-title |title=Are sirtuins markers of ovarian aging? |date=10.01.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26403315 |full-text-url=https://sci-hub.do/10.1016/j.gene.2015.09.043 }} * {{medline-title |title=The Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary Fibrosis. |date=07.09.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26370974 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613264 }} * {{medline-title |title=Sirtuin-dependent clock control: new advances in metabolism, aging and cancer. |date=11.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26335311 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610809 }} * {{medline-title |title=Mitochondrial Aging and Physical Decline: Insights From Three Generations of Women. |date=11.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26297939 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675931 }} * {{medline-title |title=Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin. |date=08.07.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26153625 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648391 }} * {{medline-title |title=[[SIRT3]] regulates progression and development of diseases of aging. |date=09.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26138757 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558250 }} * {{medline-title |title=Sirtuin Functions in Female Fertility: Possible Role in Oxidative Stress and Aging. |date=2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26075037 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436464 }} * {{medline-title |title=Differential expression of sirtuins in the aging rat brain. |date=2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26005404 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424846 }} * {{medline-title |title=A conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by [[SI]]RT3. |date=2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25830335 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382298 }} * {{medline-title |title=Expression of [[SI]]RT1 and [[SI]]RT3 varies according to age in mice. |date=03.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25806122 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371181 }} * {{medline-title |title=Practicality of intermittent fasting in humans and its effect on oxidative stress and genes related to aging and metabolism. |date=04.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25546413 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403246 }} * {{medline-title |title=Differential Effect of Endurance Training on Mitochondrial Protein Damage, Degradation, and Acetylation in the Context of Aging. |date=11.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25504576 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612384 }} * {{medline-title |title=Decreased [[SIRT3]] in aged human mesenchymal stromal/stem cells increases cellular susceptibility to oxidative stress. |date=11.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25210848 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224562 }} * {{medline-title |title=Sirtuins: guardians of mammalian healthspan. |date=07.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24877878 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077918 }} * {{medline-title |title=[[SIRT3]] deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts. |date=15.06.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24748594 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059981 }} * {{medline-title |title=Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging. |date=17.01.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24436432 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4228987 }} * {{medline-title |title=Partial reversal of skeletal muscle aging by restoration of normal NAD⁺ levels. |date=02.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24410488 |full-text-url=https://sci-hub.do/10.1089/rej.2014.1546 }} * {{medline-title |title=[Protective effects of caloric restriction on ovarian function]. |date=10.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24406130 }}
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