Редактирование: Публикации о генах и старении (titles) (раздел)

==TNF==

{{medline-entry
|title=Naringenin alleviates nonalcoholic steatohepatitis in middle-aged Apoe mice: role of SIRT1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33234364


|keywords=* AML-12 cells
* Aging
* ApoE(−/−) mice
* Naringenin
* Nonalcoholic steatohepatitis
* SIRT1
|full-text-url=https://sci-hub.do/10.1016/j.phymed.2020.153412
}}
{{medline-entry
|title=Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33212416


|keywords=* Aging
* Ferroptosis
* Heme oxygenase-1
* Iron metabolism
* Microglia
* Neuroinflammation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680814
}}
{{medline-entry
|title=Anti-aging effect of DL-β-hydroxybutyrate against hepatic cellular senescence induced by D-galactose or γ-irradiation via autophagic flux stimulation in male rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33147533


|keywords=* Autophagy
* D-galacose
* Ionizing radiation
* Senescence
* β-hydroxybutyric acid
|full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104288
}}
{{medline-entry
|title=Exploring the extensive crosstalk between the antagonistic cytokines- TGF-β and [[TNF]]-α in regulating cancer pathogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33153895


|keywords=* Apoptosis
* Autophagy
* EMT
* Fibrogenesis
* Senescence
* TGF-β and TNF-α
|full-text-url=https://sci-hub.do/10.1016/j.cyto.2020.155348
}}
{{medline-entry
|title=Long non-coding RNA SNHG29 regulates cell senescence via p53/p21 signaling in spontaneous preterm birth.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33080448


|keywords=* Cellular senescence
* Oxidative stress
* SASP
* SNHG29
* Spontaneous preterm birth
* p53/p21
|full-text-url=https://sci-hub.do/10.1016/j.placenta.2020.10.009
}}
{{medline-entry
|title=Cognition Is Associated With Peripheral Immune Molecules in Healthy Older Adults: A Cross-Sectional Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32983153


|keywords=* chemokines
* cognition
* cytokines
* healthy aging
* immune molecules
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7493640
}}
{{medline-entry
|title=Anti-aging effects of [i]Ribes meyeri[/i] anthocyanins on neural stem cells and aging mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32920547


|keywords=* Ribes meyeri anthocyanin
* aging
* cognition
* naringenin
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521483
}}
{{medline-entry
|title=Effects of a four week detraining period on physical, metabolic, and inflammatory profiles of elderly women who regularly participate in a program of strength training.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32863968


|keywords=* Aging
* Inflammation
* Physical exercise
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450596
}}
{{medline-entry
|title=Contribution of Porphyromonas gingivalis lipopolysaccharide to experimental periodontitis in relation to aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32851571


|keywords=* Aging
* Bone loss
* Osteoclastogenesis
* Periodontitis
* Porphyromonas gingivalis lipopolysaccharide
|full-text-url=https://sci-hub.do/10.1007/s11357-020-00258-1
}}
{{medline-entry
|title=New MoDC-Targeting [[TNF]] Fusion Proteins Enhance Cyclic Di-GMP Vaccine Adjuvanticity in Middle-Aged and Aged Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32849581


|keywords=* 3′
* 5′-cyclic diguanylic acid (cyclic di-GMP)
* aging
* monocyte-derived dendritic cells (moDCs)
* tumor necrosis factor (TNF)
* vaccine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7427090
}}
{{medline-entry
|title=Cognitive impairment in elderly patients with rheumatic disease and the effect of disease-modifying anti-rheumatic drugs.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32862311


|keywords=* Aging
* Biologics
* Cognition
* Rheumatic diseases
|full-text-url=https://sci-hub.do/10.1007/s10067-020-05372-1
}}
{{medline-entry
|title=Cotinine ameliorates memory and learning impairment in senescent mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32818583


|keywords=* Aging
* Cognitive impairment
* Cotinine
* Improvement
* α(7)nAChRs
|full-text-url=https://sci-hub.do/10.1016/j.brainresbull.2020.08.010
}}
{{medline-entry
|title=Kynurenines link chronic inflammation to functional decline and physical frailty.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32814718


|keywords=* Aging
* Cytokines
* Inflammation
* Neurodegeneration
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7455140
}}
{{medline-entry
|title=Voluntary exercise training attenuated the middle-aged maturity-induced cardiac apoptosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32781061

|mesh-terms=* Aging
* Animals
* Apoptosis
* Heart
* In Situ Nick-End Labeling
* Male
* Mice
* Mice, Inbred C57BL
* Mitochondria, Heart
* Muscle, Skeletal
* Physical Conditioning, Animal
* Running
* Sedentary Behavior
|keywords=* Caspase-independent
* Cell death
* Fas dependent
* IGF-related
* Mitochondrial
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118187
}}
{{medline-entry
|title=Preclinical Evaluation of a Food-Derived Functional Ingredient to Address Skeletal Muscle Atrophy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32751276


|keywords=* aging
* bioactive
* functional ingredient
* immobilization
* inflammation
* muscle atrophy
* peptide
* protein synthesis
* skeletal muscle
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7469066
}}
{{medline-entry
|title=Childhood survivors of high-risk neuroblastoma show signs of immune recovery and not immunosenescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32744364


|keywords=* adverse late effects
* childhood
* immune recovery
* immunosenescence
* neuroblastoma
|full-text-url=https://sci-hub.do/10.1002/eji.202048541
}}
{{medline-entry
|title=FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32736525


|keywords=* Endothelial cells
* Fk506
* Hyaluronan
* LYVE-1
* Lung lymphatic
* Senescence
* TERT
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395348
}}
{{medline-entry
|title=Late-onset hypogonadism: Reductio ad absurdum of the cardiovascular risk-benefit of testosterone replacement therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32737921


|keywords=* aging
* androgen
* heart failure
* myocardial infarction
* testosterone
* thromboembolism
|full-text-url=https://sci-hub.do/10.1111/andr.12876
}}
{{medline-entry
|title=Doxorubicin generates senescent microglia that exhibit altered proteomes, higher levels of cytokine secretion, and a decreased ability to internalize amyloid β.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32738344


|keywords=* Aging
* Alzheimer's disease
* Inflammation
* Microglia
* Proteomics
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.yexcr.2020.112203
}}
{{medline-entry
|title=Time restricted feeding provides a viable alternative to alternate day fasting when evaluated in terms of redox homeostasis in rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32717588


|keywords=* Aging
* Alternate day fasting (ADF)
* Intermittent fasting (IF)
* Oxidative stress
* Time-Restricted feeding (TRF)
|full-text-url=https://sci-hub.do/10.1016/j.archger.2020.104188
}}
{{medline-entry
|title=Associations Between Plasma Immunomodulatory and Inflammatory Mediators With VACS Index Scores Among Older HIV-Infected Adults on Antiretroviral Therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32695109


|keywords=* HIV
* aging
* anti-retroviral therapy
* inflammation
* morbidity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338430
}}
{{medline-entry
|title=Chrysin Impact on Oxidative and Inflammation Damages in the Liver of Aged Male Rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32679027


|keywords=* Aging
* chrysin
* inflammation
* liver
* oxidative stress
* rat.
|full-text-url=https://sci-hub.do/10.2174/1871530320666200717162304
}}
{{medline-entry
|title=Correction of immunosuppression in aged septic rats by human ghrelin and growth hormone through the vagus nerve-dependent inhibition of TGF-β production.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32677895


|keywords=* Aging
* Ghrelin
* Immunosuppression
* Sepsis
* Vagus nerve
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7364485
}}
{{medline-entry
|title=Epigenetics of neuroinflammation: Immune response, inflammatory response and cholinergic synaptic involvement evidenced by genome-wide DNA methylation analysis of delirious inpatients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32590150


|keywords=* Aging
* Delirium
* Genome-wide DNA methylation
* Immune response
* Inflammatory response
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486988
}}
{{medline-entry
|title=[i]Andrographis paniculata[/i] and Its Bioactive Diterpenoids Against Inflammation and Oxidative Stress in Keratinocytes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32560449


|keywords=* Andrographis paniculata
* andrographolide
* inflammation
* keratinocytes
* oxidative stress
* skin aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346124
}}
{{medline-entry
|title=Etanercept improves aging-induced cognitive deficits by reducing inflammation and vascular dysfunction in rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32569601


|keywords=* Aging
* Etanercept
* Inflammation
* Learning
* Memory
* TNFα
* Vascular dementia
|full-text-url=https://sci-hub.do/10.1016/j.physbeh.2020.113019
}}
{{medline-entry
|title=Bacterial antigen translocation and age as BMI-independent contributing factors on systemic inflammation in NAFLD patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32559006


|keywords=* NAFLD
* aging
* bacterial translocation
* cytokines
* insulin resistance
|full-text-url=https://sci-hub.do/10.1111/liv.14571
}}
{{medline-entry
|title=Bone marrow mesenchymal stem cells improve thymus and spleen function of aging rats through affecting P21/PCNA and suppressing oxidative stress.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32561691


|keywords=* BMSCs
* P21/PCNA
* aging
* immune system
* oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343510
}}
{{medline-entry
|title=Glycolic acid adjusted to pH 4 stimulates collagen production and epidermal renewal without affecting levels of proinflammatory [[TNF]]-alpha in human skin explants.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32583600


|keywords=* cosmetics
* glycolic acid
* keratolytic agents
* rejuvenation
* skin aging
|full-text-url=https://sci-hub.do/10.1111/jocd.13570
}}
{{medline-entry
|title=A20 of nucleus pulposus cells plays a self-protection role via the nuclear factor-kappa B pathway in the inflammatory microenvironment.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32566144


|keywords=* A20
* Nuclear factor-kappa B
* Nucleus pulposus
* Senescence
* Tumour necrosis factor alpha
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284293
}}
{{medline-entry
|title=Age-associated decline in neural, endocrine, and immune responses in men and women: Involvement of intracellular signaling pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32563124

|mesh-terms=* Adult
* Aging
* Estradiol
* Female
* Humans
* Hydrocortisone
* Immunity, Cellular
* Intracellular Fluid
* Male
* Middle Aged
* Signal Transduction
* Testosterone
* Young Adult
|keywords=* 17β-estradiol
* Cortisol
* Cytokines
* Testosterone
* Tyrosine hydroxylase
|full-text-url=https://sci-hub.do/10.1016/j.jneuroim.2020.577290
}}
{{medline-entry
|title=Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32536956


|keywords=* Aging
* Complement system
* Elderly
* Immune
* Inflammation
* Lectin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285792
}}
{{medline-entry
|title=Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on aging-dependent male osteoporosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32532246


|keywords=* Aging
* FoxO1
* Male osteoporosois
* OPG
* RANKL
* Resveratrol
* SIRT1
* Type II osteoporosis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293127
}}
{{medline-entry
|title=The senescence-associated secretome as an indicator of age and medical risk.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32554926


|keywords=* Aging
* Cellular senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406245
}}
{{medline-entry
|title=Exercise Partially Rejuvenates Muscle Stem Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32484032


|keywords=* TGF-beta
* aging
* cyclin D1
* longevity
* regeneration
* stem cells
|full-text-url=https://sci-hub.do/10.1089/rej.2020.2359
}}
{{medline-entry
|title=Brazilian berry extract (Myrciaria jaboticaba): A promising therapy to minimize prostatic inflammation and oxidative stress.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32460430

|mesh-terms=* Age Factors
* Animals
* Anti-Inflammatory Agents
* Antioxidants
* Cyclooxygenase 2
* Diet, High-Fat
* Dose-Response Relationship, Drug
* Fruit
* Interleukin-1beta
* Interleukin-6
* Lipid Peroxidation
* Male
* Mice
* Myrtaceae
* Oxidative Stress
* Plant Extracts
* Prostatitis
* T-Lymphocytes
|keywords=* aging
* bioactive compounds
* obesity
* overweight
* polyphenols
|full-text-url=https://sci-hub.do/10.1002/pros.24017
}}
{{medline-entry
|title=Potential therapeutic effects of endothelial cells trans-differentiated from Wharton's Jelly-derived mesenchymal stem cells on altered vascular functions in aged diabetic rat model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32426041


|keywords=* Aging
* Diabetes mellitus
* Endothelial cells
* Hypertension
* Mesenchymal stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216374
}}
{{medline-entry
|title=[Effect of fragmented sleep on postoperative cognitive function and central neuroinflammation].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32375444

|mesh-terms=* Aging
* Animals
* Cognition
* Cognition Disorders
* Fear
* Hippocampus
* Mice
* Mice, Inbred ICR
|keywords=* Central nervous system
* Cognition disorders
* Inflammation
* Postoperative period
* Sleep deprivation
|full-text-url=https://sci-hub.do/10.3760/cma.j.cn112137-20191215-02734
}}
{{medline-entry
|title=Can blocking inflammation enhance immunity during aging?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32386656


|keywords=* Inflammaging
* p38-MAP Kinase
* senescence
* senolytics
|full-text-url=https://sci-hub.do/10.1016/j.jaci.2020.03.016
}}
{{medline-entry
|title=[FAS- and [[TNF]]-dependent ways participation in apoptosis mechanisms in hypotalumus in physiological and pathological aging.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32362081

|mesh-terms=* Aging
* Animals
* Apoptosis
* Female
* Hypothalamus
* Mice
* Mice, Transgenic
* Signal Transduction
* Tumor Necrosis Factor-alpha
* fas Receptor
|keywords=* FAS-, TNF-dependent pathways
* aging
* apoptosis
* hypothalamus
* neurons

}}
{{medline-entry
|title=Ultrasound-guided continuous thoracic paravertebral block alleviates postoperative delirium in elderly patients undergoing esophagectomy: A randomized controlled trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32332664

|mesh-terms=* Aged
* Aged, 80 and over
* Analgesia, Patient-Controlled
* Delirium
* Esophagectomy
* Female
* Geriatrics
* Humans
* Male
* Middle Aged
* Nerve Block
* Postoperative Complications
* Prospective Studies
* Ultrasonography

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7440095
}}
{{medline-entry
|title=17β-Estradiol improves insulin signalling and insulin resistance in the aged female hearts: Role of inflammatory and anti-inflammatory cytokines.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32311377

|mesh-terms=* Aging
* Animals
* Anti-Inflammatory Agents
* Blood Glucose
* Cytokines
* Estradiol
* Female
* Heart
* Insulin
* Insulin Resistance
* Lipid Metabolism
* Menopause
* Ovariectomy
* Rats
* Rats, Wistar
* Signal Transduction
|keywords=* 17β-estradiol
* Aging
* Cytokines
* Heart
* Insulin signalling
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.117673
}}
{{medline-entry
|title=Synergistic Antitumor Efficacy of Magnetohyperthermia and Poly(lactic-co-glycolic acid)-Encapsulated Selol in Ehrlich Breast Adenocarcinoma Treatment in Elderly Swiss Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32252879

|mesh-terms=* Adenocarcinoma
* Aging
* Animals
* Cell Line, Tumor
* Glycols
* Humans
* Mice
* Nanoparticles
* Polylactic Acid-Polyglycolic Acid Copolymer
* Selenium Compounds

|full-text-url=https://sci-hub.do/10.1166/jbn.2020.2890
}}
{{medline-entry
|title=Pinitol suppresses [[TNF]]-α-induced chondrocyte senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32200264


|keywords=* Cellular senescence
* Nrf2
* Osteoarthritis
* Pinitol
* TNF-α
|full-text-url=https://sci-hub.do/10.1016/j.cyto.2020.155047
}}
{{medline-entry
|title=[Aging of skin fibroblasts: genetic and epigenetic factors.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32160428

|mesh-terms=* Cells, Cultured
* Epigenesis, Genetic
* Fibroblasts
* Humans
* Skin Aging
|keywords=* aging
* melatonin
* signal molecules
* skin fibroblasts

}}
{{medline-entry
|title=Functional and traditional training improve muscle power and reduce proinflammatory cytokines in older women: A randomized controlled trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32151735


|keywords=* Aging
* Cytokines.
* Dynapenia
* Inflamm-aging
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110920
}}
{{medline-entry
|title=Associations of [[TNF]]-α -308 G>A and [[TNF]]-β 252 A>G with Physical Function and BNP-Rugao Longevity and Ageing Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32115620

|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Female
* Humans
* Longevity
* Male
* Natriuretic Peptide, Brain
* Tumor Necrosis Factor-alpha
|keywords=* Physical function
* TNF-α -308 G>A polymorphism
* TNF-β 252 A>G polymorphism
* plasma BNP
* population study.
|full-text-url=https://sci-hub.do/10.1007/s12603-020-1336-1
}}
{{medline-entry
|title=3D TECA hydrogel reduces cellular senescence and enhances fibroblasts migration in wound healing.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32104405


|keywords=* 3D TECA
* Cellular senescence
* Fibroblast migration
* SA-β-gal
* TNF-α
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032142
}}
{{medline-entry
|title=Regulatory Effect of Anwulignan on the Immune Function Through Its Antioxidation and Anti-Apoptosis in D-Galactose-Induced Aging Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32099340

|mesh-terms=* Animals
* Antioxidants
* Apoptosis
* Cytokines
* Immunologic Factors
* Immunosenescence
* Male
* Medicine, Chinese Traditional
* Mice
* Models, Animal
* NF-E2-Related Factor 2
* Oxidative Stress
* Phytochemicals
* Schisandra
* Spleen
|keywords=* Anwulignan
* anti-apoptosis
* antioxidation
* immunosenescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996228
}}
{{medline-entry
|title=Pretreatment Frailty Is Independently Associated With Increased Risk of Infections After Immunosuppression in Patients With Inflammatory Bowel Diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32105728


|keywords=* Aging
* Immunosuppression
* Side Effect
* Thiopurine
|full-text-url=https://sci-hub.do/10.1053/j.gastro.2020.02.032
}}
{{medline-entry
|title=The Citrus Flavonoid Naringenin Protects the Myocardium from Ageing-Dependent Dysfunction: Potential Role of SIRT1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32047577

|mesh-terms=* Aging
* Animals
* Antioxidants
* Cell Line
* Cellular Senescence
* Citrus
* Cytoprotection
* Disease Models, Animal
* Flavanones
* Humans
* Interleukin-6
* Mice
* Myocardium
* Protein Binding
* Rats
* Reactive Oxygen Species
* Sirtuin 1
* Tumor Necrosis Factor-alpha

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003265
}}
{{medline-entry
|title=In the Absence of a TCR Signal IL-2/IL-12/18-Stimulated γδ T Cells Demonstrate Potent Anti-Tumoral Function Through Direct Killing and Senescence Induction in Cancer Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31947966


|keywords=* IL-12
* IL-18
* TCR bypass stimulation
* senescence
* γδ T cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017313
}}
{{medline-entry
|title=Aging is associated with loss of beneficial effects of estrogen on leptin responsiveness in mice fed high fat diet: Role of estrogen receptor α and cytokines.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31904410


|keywords=* Aging
* Cytokines
* ERα
* Estrogen
* Leptin sensitivity
|full-text-url=https://sci-hub.do/10.1016/j.mad.2019.111198
}}
{{medline-entry
|title=Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31885820

|mesh-terms=* Aging
* Alzheimer Disease
* Amyloid beta-Peptides
* Animals
* Cytokines
* Humans
* Inflammation Mediators
* Mitochondria
* Neurofibrillary Tangles
* Neurons
* Neuroprotective Agents
* Thioctic Acid

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914903
}}
{{medline-entry
|title=Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31837501

|mesh-terms=* Aging
* Alzheimer Disease
* Amyloid beta-Peptides
* Animals
* Anti-Inflammatory Agents, Non-Steroidal
* Astrocytes
* Carbamates
* Cell Line, Tumor
* Cell Survival
* Diosgenin
* Dose-Response Relationship, Drug
* Drug Design
* Galactose
* Humans
* Inflammation
* Male
* Mice
* Mice, Inbred ICR
* Molecular Structure
* Neuroprotective Agents
* Oxidative Stress
* Protein Aggregates
* Structure-Activity Relationship
|keywords=* Alzheimer’s disease
* Anti-Aβ activity
* Anti-inflammatory
* Antioxidant
* Diosgenin
* Multi-target-directed ligands
|full-text-url=https://sci-hub.do/10.1016/j.ejmech.2019.111913
}}
{{medline-entry
|title=Oral Administration of Okara Soybean By-Product Attenuates Cognitive Impairment in a Mouse Model of Accelerated Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31816987

|mesh-terms=* Aging
* Animal Feed
* Animals
* Brain-Derived Neurotrophic Factor
* Cognitive Dysfunction
* Diet
* Gastrointestinal Microbiome
* Gene Expression Regulation
* Hippocampus
* Male
* Mice
* Soybeans
* Tumor Necrosis Factor-alpha
|keywords=* BDNF
* SAMP8
* cognitive impairment
* neuroprotection
* okara
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950093
}}
{{medline-entry
|title=Electric vagal nerve stimulation inhibits inflammation and improves early postoperation cognitive dysfunction in aged rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31759387

|mesh-terms=* Aging
* Anesthesia, General
* Animals
* Behavior, Animal
* Hippocampus
* Inflammation
* Male
* Maze Learning
* NF-kappa B
* Postoperative Cognitive Complications
* Rats
* Rats, Sprague-Dawley
* Splenectomy
* Tumor Necrosis Factor-alpha
* Vagus Nerve Stimulation
|keywords=* Cognitive dysfunction
* General anesthesia
* Inflammation
* Vagus nerve stimulation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875068
}}
{{medline-entry
|title=Metformin decreases LPS-induced inflammatory response in rabbit annulus fibrosus stem/progenitor cells by blocking HMGB1 release.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31772144

|mesh-terms=* Animals
* Annulus Fibrosus
* Anti-Inflammatory Agents
* Cellular Senescence
* HMGB1 Protein
* Inflammation
* Intervertebral Disc Degeneration
* Lipopolysaccharides
* Metformin
* Rabbits
* Stem Cells
|keywords=* HMGB1
* annulus fibrosis stem cells
* cell senescence
* intervertebral disc degeneration
* metformin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914423
}}
{{medline-entry
|title=The effects of blueberry and strawberry serum metabolites on age-related oxidative and inflammatory signaling in vitro.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31746877

|mesh-terms=* Aged
* Aging
* Animals
* Blueberry Plants
* Double-Blind Method
* Female
* Fragaria
* Fruit
* Humans
* Male
* Microglia
* Middle Aged
* Nitric Oxide
* Nitric Oxide Synthase Type II
* Oxidative Stress
* Postprandial Period
* Rats
* Tumor Necrosis Factor-alpha

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906224
}}
{{medline-entry
|title=Arsenic induces human chondrocyte senescence and accelerates rat articular cartilage aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31734849


|keywords=* Aging
* Arsenic
* Articular cartilage
* Human chondrocyte
* Senescence
* Senescence-associated secretory phenotype
|full-text-url=https://sci-hub.do/10.1007/s00204-019-02607-2
}}
{{medline-entry
|title=Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31717258

|mesh-terms=* Age Factors
* Animals
* Bone Density
* Bone Density Conservation Agents
* Bone Marrow Cells
* Bone Remodeling
* Bone and Bones
* Cells, Cultured
* Cytokines
* Dietary Supplements
* Disease Models, Animal
* Docosahexaenoic Acids
* Eicosapentaenoic Acid
* Female
* JNK Mitogen-Activated Protein Kinases
* Mice, Inbred C57BL
* Osteoporosis
* Signal Transduction
* p38 Mitogen-Activated Protein Kinases
|keywords=* aging
* bone mineral density
* bone resorption
* concentrated fish oil
* cytokines
* inflammation
* omega-3 fatty acids
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893665
}}
{{medline-entry
|title=Inflammaging phenotype in rhesus macaques is associated with a decline in epithelial barrier-protective functions and increased pro-inflammatory function in CD161-expressing cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31713098

|mesh-terms=* Aging
* Animals
* Chronic Disease
* Cytokines
* Disease Models, Animal
* Epithelium
* Flow Cytometry
* Immunity, Innate
* Inflammation
* Macaca mulatta
* NK Cell Lectin-Like Receptor Subfamily B
* Phenotype
* Th17 Cells
|keywords=* CD161+ cells
* I-FABP
* Inflammaging
* LBP
* Leaky gut
* sCD14
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925095
}}
{{medline-entry
|title=Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31719197

|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* B-Lymphocytes
* CD4-Positive T-Lymphocytes
* Case-Control Studies
* Cell Differentiation
* Cells, Cultured
* Clonal Evolution
* Gene Expression Profiling
* Humans
* Interferon-gamma
* Leukocytes, Mononuclear
* Middle Aged
* Single-Cell Analysis
* Tumor Necrosis Factor-alpha
|keywords=* CD4 CTL
* aging
* centenarian
* single-cell transcriptome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883788
}}
{{medline-entry
|title=Gut microbiota combined with metabolomics reveals the metabolic profile of the normal aging process and the anti-aging effect of FuFang Zhenshu TiaoZhi(FTZ) in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31704617

|mesh-terms=* Aging
* Animals
* Bacteria
* Biomarkers
* Drugs, Chinese Herbal
* Gastrointestinal Microbiome
* Hyperlipidemias
* Lipid Metabolism
* Male
* Metabolome
* Metabolomics
* Mice
* Mice, Inbred C57BL
|keywords=* Aging
* FTZ
* Gut microbiota
* Metabolomics
|full-text-url=https://sci-hub.do/10.1016/j.biopha.2019.109550
}}
{{medline-entry
|title=Intervertebral disc ageing and degeneration: The antiapoptotic effect of oestrogen.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31669486

|mesh-terms=* Aging
* Animals
* Apoptosis
* Cytokines
* Estrogens
* Female
* Humans
* Inflammation
* Intervertebral Disc
* Intervertebral Disc Degeneration
* Intervertebral Disc Displacement
* Male
* Phosphatidylinositol 3-Kinases
* Signal Transduction
|keywords=* Ageing
* Apoptosis
* Intervertebral disc degeneration
* Oestrogen
* Spine
|full-text-url=https://sci-hub.do/10.1016/j.arr.2019.100978
}}
{{medline-entry
|title=MicroRNA 16-5p is upregulated in calorie-restricted mice and modulates inflammatory cytokines of macrophages.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31654705

|mesh-terms=* Aging
* Animals
* Caloric Restriction
* Cytokines
* Diet Therapy
* Inflammation
* Interleukin-1beta
* Macrophages
* Male
* Mice
* Mice, Inbred C57BL
* MicroRNAs
* Models, Animal
* RAW 264.7 Cells
* Transcriptional Activation
* Tumor Necrosis Factor-alpha
* Up-Regulation
|keywords=* Caloric restriction
* Cellular immunology
* Cytokines
* Macrophages
* microRNA
|full-text-url=https://sci-hub.do/10.1016/j.gene.2019.144191
}}
{{medline-entry
|title=Aerobic exercise modulates cytokine profile and sleep quality in elderly.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31656505

|mesh-terms=* Aged
* Cytokines
* Exercise
* Female
* Humans
* Male
* Middle Aged
* Sedentary Behavior
* Sleep Wake Disorders
|keywords=* Sleep quality
* aerobic exercise
* aging
* inflammatory cytokines
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794533
}}
{{medline-entry
|title=Trehalose targets Nrf2 signal to alleviate d-galactose induced aging and improve behavioral ability.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31630800

|mesh-terms=* Aging
* Animals
* Disease Models, Animal
* Dose-Response Relationship, Drug
* Galactose
* Male
* Memory Disorders
* Mice
* Mice, Inbred ICR
* NF-E2-Related Factor 2
* Signal Transduction
* Trehalose
|keywords=* Antioxidant stress
* Cognitive impairment
* Inflammation
* Nrf2
* Trehalose
* d-galactose
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2019.10.088
}}
{{medline-entry
|title=Anti-Inflammatory and Anti-Aging Evaluation of Pigment-Protein Complex Extracted from [i]Chlorella Pyrenoidosa[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31623220

|mesh-terms=* Aging
* Animals
* Anti-Inflammatory Agents
* Antioxidants
* Biological Products
* Chlorella
* Cytokines
* Disease Models, Animal
* Galactose
* Inflammation
* Interleukin-6
* Lipopolysaccharides
* Macrophages
* Male
* Mice
* Mice, Inbred C57BL
* NF-kappa B
* Nitric Oxide
* Oxidative Stress
* RAW 264.7 Cells
* Superoxide Dismutase
* Tumor Necrosis Factor-alpha
|keywords=* Chlorella pyrenoidosa
* NF-κB
* PPARs
* anti-aging
* anti-inflammation
* pigment–protein complex
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836285
}}
{{medline-entry
|title=Inflammatory mediators and the risk of falls among older women with acute low back pain: data from Back Complaints in the Elders (BACE)-Brazil.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31606818


|keywords=* Aging
* BACE
* Cytokines
* Disability
* Fall risk
* Low back pain
|full-text-url=https://sci-hub.do/10.1007/s00586-019-06168-x
}}
{{medline-entry
|title=Acetylcholinesterase inhibitors targeting the cholinergic anti-inflammatory pathway: a new therapeutic perspective in aging-related disorders.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31583530


|keywords=* Acetylcholinesterase inhibitor
* Aging
* CHRFAM7A
* CHRNA7
* Cholinergic anti-inflammatory pathway
* Neuroinflammation
|full-text-url=https://sci-hub.do/10.1007/s40520-019-01359-4
}}
{{medline-entry
|title=Study on Metabolic Trajectory of Liver Aging and the Effect of Fufang Zhenzhu Tiaozhi on Aging Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31555127


|keywords=* Fufang Zhenzhu Tiaozhi
* liver aging
* mass spectrometry
* metabolomics
* ultra-performance liquid chromatography
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722462
}}
{{medline-entry
|title=Systemic Tumor Necrosis Factor-Alpha Trajectories Relate to Brain Health in Typically Aging Older Adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31549145


|keywords=* Brain aging
* Cognition
* Gray matter volume
* Inflammation
* Neuroimaging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457183
}}
{{medline-entry
|title=Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31521202

|mesh-terms=* Adipose Tissue
* Adult
* Cell Movement
* Cell Proliferation
* Cell Survival
* Cellular Senescence
* Dasatinib
* Female
* Humans
* Mesenchymal Stem Cells
* Pre-Eclampsia
* Pregnancy
* Protein Kinase Inhibitors
|keywords=* Angiogenesis, Senolytics, Dasatinib
* Mesenchymal stem cells
* Preeclampsia
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744626
}}
{{medline-entry
|title=Suppression of gut dysbiosis by Bifidobacterium longum alleviates cognitive decline in 5XFAD transgenic and aged mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31413350

|mesh-terms=* Aging
* Animals
* Bifidobacterium longum
* Cognitive Dysfunction
* Dysbiosis
* Feces
* Gastrointestinal Microbiome
* Humans
* Lipopolysaccharides
* Mice
* Mice, Transgenic
* Probiotics

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694197
}}
{{medline-entry
|title=Moderate hyperoxia induces senescence in developing human lung fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31411059

|mesh-terms=* Autophagy
* CCAAT-Enhancer-Binding Protein-beta
* Cell Proliferation
* Cellular Senescence
* Cyclin-Dependent Kinase Inhibitor p21
* DNA Damage
* Endoplasmic Reticulum Stress
* Etoposide
* Extracellular Matrix
* Fetus
* Fibroblasts
* G2 Phase Cell Cycle Checkpoints
* Gene Expression Regulation
* Humans
* Hyperoxia
* Interleukin-1
* Interleukin-8
* Lung
* Matrix Metalloproteinase 3
* Oxygen
* Plasminogen Activator Inhibitor 1
* Primary Cell Culture
* Tumor Necrosis Factor-alpha
* Tumor Suppressor Protein p53
|keywords=* autophagy
* endoplasmic reticulum stress
* lung development
* oxygen
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6879905
}}
{{medline-entry
|title=Aging-related carcinoembryonic antigen-related cell adhesion molecule 1 signaling promotes vascular dysfunction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31389127

|mesh-terms=* Aged
* Aging
* Animals
* Antigens, CD
* Cell Adhesion Molecules
* Cells, Cultured
* Endothelium, Vascular
* Humans
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Middle Aged
* Signal Transduction
|keywords=* aging
* anti-aging
* cytokines
* inflammation
* mouse
* reactive oxygen species
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826129
}}
{{medline-entry
|title=Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APP /PS1  Transgenic Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31417357


|keywords=* aging
* cerebral amyloidosis
* insulin-like growth factor
* neurogenesis
* neuroinflammation
* tumor necrosis factor
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682662
}}
{{medline-entry
|title=Age- and diet-specific effects of chronic exposure to chlorpyrifos on hormones, inflammation and gut microbiota in rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31400786

|mesh-terms=* Aging
* Animals
* Chlorpyrifos
* Diet, High-Fat
* Gastrointestinal Microbiome
* Hypothalamo-Hypophyseal System
* Inflammation
* Male
* Pituitary-Adrenal System
* RNA, Ribosomal, 16S
* Rats
|keywords=* 16S rRNA gene sequencing
* Gut endocrine
* Gut-brain axis
* Hormone
* Hypothalamic-pituitary-adrenal axis
* Inflammation
|full-text-url=https://sci-hub.do/10.1016/j.pestbp.2019.05.018
}}