Редактирование: Публикации о генах и старении (titles) (раздел)

==SIRT1==

{{medline-entry
|title=Anthocyanins attenuate endothelial dysfunction through regulation of uncoupling of nitric oxide synthase in aged rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33274583


|keywords=* NO
* SIRT1
* anthocyanins
* eNOS deacetylation
* senescence
|full-text-url=https://sci-hub.do/10.1111/acel.13279
}}
{{medline-entry
|title=Sirtuins and Their Implications in Neurodegenerative Diseases from a Drug Discovery Perspective.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33280374


|keywords=* Aging
* neurodegenerative diseases
* neuroprotective
* sirtuin
* sirtuin activators
* sirtuin inhibitors
|full-text-url=https://sci-hub.do/10.1021/acschemneuro.0c00696
}}
{{medline-entry
|title=Effects of alpha-mangostin on memory senescence induced by high glucose in human umbilical vein endothelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33149857


|keywords=* Cellular senescence
* Diabetes
* Diabetes complications
* Endothelial cells
* Garcinia mangostana
* Hyperglycemia
* Mangostin
* Metabolic syndrome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7585532
}}
{{medline-entry
|title=[[SIRT1]] Activation Using CRISPR/dCas9 Promotes Regeneration of Human Corneal Endothelial Cells through Inhibiting Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33158256


|keywords=* CRISPR/dCas9
* SIRT1
* corneal endothelial cells
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7694272
}}
{{medline-entry
|title=Histone Deacetylase [[SIRT1]], Smooth Muscle Cell Function, and Vascular Diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33117155


|keywords=* SIRT1
* SIRT1 activators
* calorie restriction
* senescence
* vascular diseases
* vascular smooth muscle cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573826
}}
{{medline-entry
|title=6,4'-dihydroxy-7-methoxyflavanone protects against H O -induced cellular senescence by inducing [[SIRT1]] and inhibiting phosphatidylinositol 3-kinase/Akt pathway activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33111210


|keywords=* 6,4′-dihydroxy-7-methoxyflavanone
* Akt
* Oxidative stress
* Premature senescence
* SIRT1
|full-text-url=https://sci-hub.do/10.1007/s11010-020-03951-z
}}
{{medline-entry
|title=Isoparvifuran isolated from Dalbergia odorifera attenuates H O -induced senescence of BJ cells through [[SIRT1]] activation and AKT/mTOR pathway inhibition.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33010892


|keywords=* AKT/mTOR signaling pathway
* Antioxidant: SIRT1
* Cellular senescence
* Isoparvifuran
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2020.09.096
}}
{{medline-entry
|title=[[SIRT1]] Is the Target Gene for 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside Alleviating the HUVEC Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33013385


|keywords=* 2,3,5,4’-tetrahydroxystilbene-2-O-β-d-glucoside
* SIRT1
* human umbilical vein cells
* hydrogen peroxide
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508177
}}
{{medline-entry
|title=The Role of Sirtuins in Kidney Diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32932720


|keywords=* acute kidney injury
* aging kidney
* chronic kidney disease
* diabetic nephropathy
* kidney
* sirtuins
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555196
}}
{{medline-entry
|title=The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32919015


|keywords=* Cellular senescence
* Elderly
* Resistance training
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111090
}}
{{medline-entry
|title=Virus-Induced Asthma Exacerbations: [[SIRT1]] Targeted Approach.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32823491


|keywords=* SIRT1
* asthma
* cellular senescence
* exacerbations
* virus infection
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464235
}}
{{medline-entry
|title=Novel resveratrol derivatives have diverse effects on the survival, proliferation and senescence of primary human fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32793997


|keywords=* Resveratrol
* SIRT1
* Senescence
* Toxicity
|full-text-url=https://sci-hub.do/10.1007/s10522-020-09896-6
}}
{{medline-entry
|title=Glucose restriction delays senescence and promotes proliferation of HUVECs via the AMPK/[[SIRT1]]-FOXA3-Beclin1 pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32768436


|keywords=* Beclin1
* Endothelial cells
* FOXA3
* Glucose restriction
* Proliferation
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.111053
}}
{{medline-entry
|title=Therapeutic Effects of SRT2104 on Lung Injury in Rats with Emphysema via Reduction of Type II Alveolar Epithelial Cell Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32722945


|keywords=* Sirtuin 1
* alveolar epithelial cells
* cellular senescence
* chronic obstructive pulmonary disease
* cigarette smoking
|full-text-url=https://sci-hub.do/10.1080/15412555.2020.1797657
}}
{{medline-entry
|title=Latifolin Inhibits Oxidative Stress-Induced Senescence via Upregulation of [[SIRT1]] in Human Dermal Fibroblasts.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32404543


|keywords=* human dermal fibroblast
* latifolin
* mammalian target of rapamycin
* oxidative stress
* senescence
* silent information regulator 1
|full-text-url=https://sci-hub.do/10.1248/bpb.b20-00094
}}
{{medline-entry
|title=SRT1720-induced activation of [[SIRT1]] alleviates vascular smooth muscle cell senescence through PKA-dependent phosphorylation of AMPKα at Ser485.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32421926


|keywords=* SIRT1
* SRT1720
* VSMC senescence
* p-AMPK (Ser485)
* telomere length
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327920
}}
{{medline-entry
|title=miR-128 plays a critical role in murine osteoclastogenesis and estrogen deficiency-induced bone loss.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32292498


|keywords=* PMOP
* aging
* inflammation
* miR-128
* osteoclastogenesis
* ovariectomy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7150474
}}
{{medline-entry
|title=Lymphocyte senescence in COPD is associated with decreased sirtuin 1 expression in steroid resistant pro-inflammatory lymphocytes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32270742


|keywords=* CD28nullCD8+ T and NKT-like cells
* COPD
* IFNγ and TNFα
* SIRT1
* lymphocyte senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7153179
}}
{{medline-entry
|title=Therapeutic effects of hydro-alcoholic leaf extract of Withania somnifera on age-induced changes in daily rhythms of Sirt1, Nrf2 and Rev-erbα in the SCN of male Wistar rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32249404


|keywords=* Aging
* Ashwagandha
* Circadian clock
* NRF2
* SCN
* SIRT1
|full-text-url=https://sci-hub.do/10.1007/s10522-020-09875-x
}}
{{medline-entry
|title=The Serum Concentration of Anti-Aging Proteins, Sirtuin1 and αKlotho in Patients with End-Stage Kidney Disease on Maintenance Hemodialysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32214805

|mesh-terms=* Age Factors
* Aged
* Aging
* Biomarkers
* Blood Pressure
* Cardiovascular Diseases
* Case-Control Studies
* Diabetes Complications
* Echocardiography
* Female
* Glucuronidase
* Heart Ventricles
* Humans
* Kidney
* Kidney Failure, Chronic
* Male
* Middle Aged
* Renal Dialysis
* Sirtuin 1
* Stroke Volume
|keywords=* chronic kidney disease
* hemodialysis
* sirtuin1
* αKlotho
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084123
}}
{{medline-entry
|title=Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32158519


|keywords=* Cellular senescence
* DNMT1
* SIRT1
* extracellular vesicles
* microRNAs
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048230
}}
{{medline-entry
|title=Spatiotemporal gating of [[SIRT1]] functions by O-GlcNAcylation is essential for liver metabolic switching and prevents hyperglycemia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32152092

|mesh-terms=* Acetylglucosamine
* Aging
* Animals
* Fasting
* Gluconeogenesis
* Glycosylation
* HEK293 Cells
* Homeostasis
* Humans
* Hyperglycemia
* Insulin Resistance
* Liver
* Male
* Mice
* Mice, Inbred C57BL
* Obesity
* Phosphorylation
* Protein Processing, Post-Translational
* Sirtuin 1
* Spatio-Temporal Analysis
|keywords=* PGC1α
* fed–fast cycle
* gluconeogenesis
* insulin signaling
* ubiquitinylation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104039
}}
{{medline-entry
|title=Hydrogen Sulfide Inhibits Homocysteine-Induced Neuronal Senescence by Up-Regulation of [[SIRT1]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32132865


|keywords=* SIRT1
* cell senescence
* homocysteine
* hydrogen sulfide
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053352
}}
{{medline-entry
|title=[[SIRT1]] and aging related signaling pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32084459


|keywords=* Aging
* Deacetylate
* NAD(+)
* SIRT1
* Signaling pathways
|full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111215
}}
{{medline-entry
|title=Tropisetron protects against brain aging via attenuating oxidative stress, apoptosis and inflammation: The role of [[SIRT1]] signaling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32088214

|mesh-terms=* Aging
* Animals
* Antioxidants
* Apoptosis
* Brain
* Drug Administration Schedule
* Galactose
* Gene Expression Regulation
* Inflammation
* Injections, Intraperitoneal
* Injections, Subcutaneous
* Interleukin-6
* Male
* Mice
* Mitochondria
* Neurons
* Nitric Oxide
* Oxidative Stress
* Proto-Oncogene Proteins c-bcl-2
* Reactive Oxygen Species
* Serotonin 5-HT3 Receptor Antagonists
* Sirtuin 1
* Tropisetron
* Tumor Necrosis Factor-alpha
* bcl-2-Associated X Protein
|keywords=* Aging
* Brain
* Neurotoxicity
* Sirtuin 1
* Tropisetron
* d-galactose
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.117452
}}
{{medline-entry
|title=Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of [[SIRT1]] activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32056076


|keywords=* Aging
* Geroscience
* Mitochondria dysfunction
* Transcriptomics
* Vascular cognitive impairment
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206476
}}
{{medline-entry
|title=Deacetylation of MRTF-A by [[SIRT1]] defies senescence induced down-regulation of collagen type I in fibroblast cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32061777

|mesh-terms=* Acetylation
* Animals
* Benzamides
* Carbazoles
* Cellular Senescence
* Collagen Type I
* Down-Regulation
* Embryo, Mammalian
* Fibroblasts
* HEK293 Cells
* Heterocyclic Compounds, 4 or More Rings
* Humans
* Mice
* Mutation
* Naphthols
* Primary Cell Culture
* Promoter Regions, Genetic
* RNA, Small Interfering
* Resveratrol
* Sirtuin 1
* Trans-Activators
|keywords=* Collagen type I
* Fibroblast
* Lysine deacetylation
* Post-translational modification
* Senescence
* Transcriptional regulation
|full-text-url=https://sci-hub.do/10.1016/j.bbadis.2020.165723
}}
{{medline-entry
|title=Chronic Polyphenon-60 or Catechin Treatments Increase Brain Monoamines Syntheses and Hippocampal [[SIRT1]] Levels Improving Cognition in Aged Rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31991916

|mesh-terms=* Age Factors
* Animals
* Behavior, Animal
* Biogenic Monoamines
* Catechin
* Cognition
* Cognitive Aging
* Corpus Striatum
* Hippocampus
* Male
* Memory, Episodic
* Memory, Short-Term
* Neuroprotective Agents
* Rats, Sprague-Dawley
* Sirtuin 1
* Time Factors
|keywords=* NF-κB
* RBAP46/48
* SIRT1
* brain aging
* brain monoamine synthesis
* catechin
* green tea
* memory
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071257
}}
{{medline-entry
|title=Duck Oil-loaded Nanoemulsion Inhibits Senescence of Angiotensin II-treated Vascular Smooth Muscle Cells by Upregulating [[SIRT1]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31970335


|keywords=* SIRT1
* angiotensin II
* duck oil
* nanoemulsion
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957441
}}
{{medline-entry
|title=Two novel [[SIRT1]] activators, SCIC2 and SCIC2.1, enhance [[SIRT1]]-mediated effects in stress response and senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31942817


|keywords=* Sirtuins
* drug discovery
* epigenetic modulators
* senescence
* stress response
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7574383
}}
{{medline-entry
|title=Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31881011

|mesh-terms=* A549 Cells
* Alveolar Epithelial Cells
* Apoptosis
* Cellular Senescence
* Humans
* Hydrogen Sulfide
* Mitochondria
* Oxidative Stress
* Sirtuin 1
* Smoke
* Tobacco
* Up-Regulation
|keywords=* alveolar epithelial cell
* cigarette smoke extract
* hydrogen sulfide
* mitochondria injury
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949053
}}
{{medline-entry
|title=The protective role of omentin-1 in IL-1β-induced chondrocyte senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31852248

|mesh-terms=* Adipokines
* Caveolin 1
* Cell Line, Tumor
* Cellular Senescence
* Chondrocytes
* Cyclin-Dependent Kinase Inhibitor p21
* Cytoprotection
* G1 Phase Cell Cycle Checkpoints
* Humans
* Interleukin-1beta
* Plasminogen Activator Inhibitor 1
* Sirtuin 1
* Transcriptional Activation
|keywords=* IL-1β
* Omentin-1
* SIRT-1
* chondrocyte senescence
|full-text-url=https://sci-hub.do/10.1080/21691401.2019.1699803
}}
{{medline-entry
|title=The Lifespan Extension Ability of Nicotinic Acid Depends on Whether the Intracellular NAD  Level Is Lower than the Sirtuin-Saturating Concentrations.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31878234

|mesh-terms=* Animals
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Caloric Restriction
* Cell Line
* Humans
* NAD
* Niacin
* Sirtuins
* beta-Galactosidase
|keywords=* C. elegans
* Hs68 cells
* NAD+
* calorie restriction mimetic
* lifespan
* nicotinic acid
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982340
}}
{{medline-entry
|title=Alpha-mangostin decreased cellular senescence in human umbilical vein endothelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31792920


|keywords=* Alpha-mangostin
* Diabetes
* HUVEC
* High glucose
* SIRT1
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214571
}}
{{medline-entry
|title=Central nervous system [[SIRT1]] expression is required for cued and contextual fear conditioning memory responses in aging mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31763496


|keywords=* Fear conditioning
* SIRT1
* aging
* classically conditioned memory
* hippocampus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839599
}}
{{medline-entry
|title=Does education level protect us from rapid ageing? Sirtuin expression versus age and level of education.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31785216

|mesh-terms=* Adolescent
* Adult
* Age Factors
* Aging
* Aging, Premature
* Educational Status
* Epigenesis, Genetic
* Female
* Gene Expression Regulation, Enzymologic
* Histones
* Humans
* Learning
* Male
* Middle Aged
* Sirtuins
* Young Adult


}}
{{medline-entry
|title=CO ameliorates endothelial senescence induced by 5-fluorouracil through [[SIRT1]] activation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31704100

|mesh-terms=* Antioxidants
* Carbon Monoxide
* Cellular Senescence
* Down-Regulation
* Fluorouracil
* Heme Oxygenase-1
* Human Umbilical Vein Endothelial Cells
* Humans
* Nitric Oxide Synthase Type III
* Reactive Oxygen Species
* Sirtuin 1
|keywords=* 5-Fluorouracil
* Carbon monoxide
* Endothelial senescence
* Reactive oxygen species
* SIRT1
|full-text-url=https://sci-hub.do/10.1016/j.abb.2019.108185
}}
{{medline-entry
|title=Long noncoding RNA GAS5 inhibits cell proliferation and fibrosis in diabetic nephropathy by sponging miR-221 and modulating [[SIRT1]] expression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31631065

|mesh-terms=* Aging
* Animals
* Argonaute Proteins
* Cell Proliferation
* Diabetes Mellitus, Experimental
* Diabetic Nephropathies
* Fibrosis
* Gene Deletion
* Gene Expression Regulation
* Glucose
* Male
* Mesangial Cells
* Mice
* MicroRNAs
* RAW 264.7 Cells
* RNA, Long Noncoding
* Rats
* Rats, Sprague-Dawley
* Sirtuin 1
|keywords=* diabetic nephropathy
* fibrosis
* lncRNA GAS5
* proliferation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834398
}}
{{medline-entry
|title=The Role of Sirtuin1 in Regulating Endothelial Function, Arterial Remodeling and Vascular Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31572218


|keywords=* PVAT
* SIRT1
* eNOS
* vascular aging
* vascular remodeling
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751260
}}
{{medline-entry
|title=Deacetylation of LAMP1 drives lipophagy-dependent generation of free fatty acids by Abrus agglutinin to promote senescence in prostate cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31544977


|keywords=* Abrus agglutinin
* LAMP1
* SIRT1
* free fatty acid
* lipophagy
* reactive oxygen species
* senescence
|full-text-url=https://sci-hub.do/10.1002/jcp.29182
}}
{{medline-entry
|title=Plasma exosomes in OSA patients promote endothelial senescence: effect of long-term adherent continuous positive airway pressure.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31552414


|keywords=* CPAP
* OSA
* aging
* cardiovascular
* endothelium
* exosomes
* extracellular vesicles
* intermittent hypoxia
* oxidative stress
* senescence
|full-text-url=https://sci-hub.do/10.1093/sleep/zsz217
}}
{{medline-entry
|title=Hydrogen Sulfide Inhibits High Glucose-Induced Neuronal Senescence by Improving Autophagic Flux [i]via[/i] Up-regulation of [[SIRT1]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31481873


|keywords=* SIRT1
* autophagic flux
* high glucose
* hydrogen sulfide
* neuronal senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710442
}}
{{medline-entry
|title=Activation of the miR-34a-Mediated [[SIRT1]]/mTOR Signaling Pathway by Urolithin A Attenuates D-Galactose-Induced Brain Aging in Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31420820

|mesh-terms=* Aging
* Animals
* Brain
* Coumarins
* Galactose
* Male
* Mice
* Mice, Inbred ICR
* MicroRNAs
* PC12 Cells
* Random Allocation
* Rats
* Signal Transduction
* Sirtuin 1
* TOR Serine-Threonine Kinases
|keywords=* D-Gal
* SIRT1/mTOR signal pathway
* Urolithin A
* aging
* autophagy
* miR-34a
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985387
}}