Редактирование: Публикации о генах и старении (titles) (раздел)

==RPE==

{{medline-entry
|title=Transcriptomic Profiling of Human Pluripotent Stem Cell-derived Retinal Pigment Epithelium over Time.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33307245


|keywords=* Aging
* Human embryonic stem cell
* Human pluripotent stem cell
* Retinal pigment epithelium
* Single-cell RNA sequencing
|full-text-url=https://sci-hub.do/10.1016/j.gpb.2020.08.002
}}
{{medline-entry
|title=Relationship between Oxygen Uptake, Heart Rate, and Perceived Effort in an Aquatic Incremental Test in Older Women.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33187067


|keywords=* aging
* cardiorespiratory
* maximum test
* rate of perceived exertion
* water aerobics
* water-based exercises
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697777
}}
{{medline-entry
|title=Photoreceptor Degeneration in Homozygous Male Per2  Mice During Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33135952


|keywords=* Per2luc
* aging
* circadian
* mice
* photoreceptors
* retinal pigment epithelium
|full-text-url=https://sci-hub.do/10.1177/0748730420965285
}}
{{medline-entry
|title=An In-Vitro Cell Model of Intracellular Protein Aggregation Provides Insights into [[RPE]] Stress Associated with Retinopathy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32932802


|keywords=* AMD
* RPE
* aging
* autofluorescence
* autophagy
* diet
* lysosomes
* oxidized POS
* proteolysis
* retina
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555953
}}
{{medline-entry
|title=Short-Term Effect of Self-Selected Training Intensity on Ambulatory Blood Pressure in Hypertensive Older Women: A Randomized Controlled Trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32904579


|keywords=* aging
* exercise
* hypertension
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457386
}}
{{medline-entry
|title=Correlation between brain volume and retinal photoreceptor outer segment volume in normal aging and neurodegenerative diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32881874

|mesh-terms=* Aged
* Aging
* Brain
* Female
* Humans
* Linear Models
* Magnetic Resonance Imaging
* Male
* Middle Aged
* Multivariate Analysis
* Neurodegenerative Diseases
* Organ Size
* Retinal Photoreceptor Cell Outer Segment
* Retinal Pigment Epithelium
* Tomography, Optical Coherence

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7470418
}}
{{medline-entry
|title=Oxidative stress in the retina and retinal pigment epithelium ([[RPE]]): Role of aging, and DJ-1.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32826201


|keywords=* Aging
* DJ-1
* Oxidative stress
* Retina
* Retinal pigment epithelium
* Sodium iodate
|full-text-url=https://sci-hub.do/10.1016/j.redox.2020.101623
}}
{{medline-entry
|title=Direct-Coupled Electroretinogram (DC-ERG) for Recording the Light-Evoked Electrical Responses of the Mouse Retinal Pigment Epithelium.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32744516

|mesh-terms=* Aging
* Animals
* Electrophysiological Phenomena
* Electroretinography
* Light
* Mice
* Retinal Pigment Epithelium

|full-text-url=https://sci-hub.do/10.3791/61491
}}
{{medline-entry
|title=High-density lipoproteins are a potential therapeutic target for age-related macular degeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32737203


|keywords=* age-related macular degeneration
* aging
* apolipoprotein
* complement
* complement factor H
* glycosaminoglycan
* heparan sulfate
* heparan sulfate proteoglycans
* high-density lipoprotein (HDL)
* lipoprotein
* oligosaccharide
* retinal degeneration
* retinal pigmented epithelium
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521644
}}
{{medline-entry
|title=MTOR-initiated metabolic switch and degeneration in the retinal pigment epithelium.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32721041


|keywords=* AMD
* Mtor
* aging
* lipid
* metabolism
|full-text-url=https://sci-hub.do/10.1096/fj.202000612R
}}
{{medline-entry
|title=[i]Lactobacillus paracasei[/i] KW3110 Suppresses Inflammatory Stress-Induced Premature Cellular Senescence of Human Retinal Pigment Epithelium Cells and Reduces Ocular Disorders in Healthy Humans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32708511


|keywords=* cellular senescence
* eye fatigue
* inflammation
* lactic acid bacteria
* probiotics
* retina
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403967
}}
{{medline-entry
|title=Retinal pigment epithelium transcriptome analysis in chronic smoking reveals a suppressed innate immune response and activation of differentiation pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32634473


|keywords=* Age-related macular degeneration
* Aging
* Differentiation
* Innate immunity
* RNA sequencing
* Smoking
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7434665
}}
{{medline-entry
|title=Differences in Intraretinal Pigment Migration Across Inherited Retinal Dystrophies.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32442431

|mesh-terms=* Adult
* Aging
* Cell Movement
* Female
* Follow-Up Studies
* Humans
* Male
* Ophthalmoscopy
* Retinal Dystrophies
* Retinal Pigment Epithelium
* Retrospective Studies
* Slit Lamp Microscopy
* Tomography, Optical Coherence

|full-text-url=https://sci-hub.do/10.1016/j.ajo.2020.05.010
}}
{{medline-entry
|title=Exosomal MiRNA Transfer between Retinal Microglia and [[RPE]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32429541


|keywords=* RPE
* aging
* exosome
* inflammation
* microglia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279010
}}
{{medline-entry
|title=Functionally validated imaging endpoints in the Alabama study on early age-related macular degeneration 2 (ALSTAR2): design and methods.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32429847


|keywords=* Age-related macular degeneration
* Aging
* Cones
* Dark adaptation
* Light sensitivity
* Macula
* Quantitative autofluorescence
* Retina
* Rods
* Spectral domain optical coherence tomography
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236516
}}
{{medline-entry
|title=Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32298788


|keywords=* Age-related macular degeneration
* Aggregation
* Aging
* Autophagy
* Clearance
* Degeneration
* Mitochondria
* Mitophagy
* Retina
* Retinal pigment epithelium
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7650008
}}
{{medline-entry
|title=CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and [[RPE]] disorganization.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32234210


|keywords=* RPE disorganization
* aging
* choroid
* choroidal macrophage
* choroidal vasculature
* immunology
* inflammation
* mouse
* neuroscience
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156269
}}
{{medline-entry
|title=Extracellular microparticles exacerbate oxidative damage to retinal pigment epithelial cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32173468


|keywords=* Extracellular vesicles
* Oxidative stress
* Phagocytosis
* RPE cell Dysfunction
* RPE cell-Derived microparticles (RMPs)
* Retinal pigment epithelial cell (RPE)
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.yexcr.2020.111957
}}
{{medline-entry
|title=Water-based continuous and interval training in older women: Cardiorespiratory and neuromuscular outcomes (WATER study).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32145293


|keywords=* Aerobic capacity
* Aerobic training
* Aging
* Aquatic exercise
* Interval exercise
* Muscle echo intensity
* Muscle strength
* Muscle thickness
|full-text-url=https://sci-hub.do/10.1016/j.exger.2020.110914
}}
{{medline-entry
|title=Retrieval Practice Improves Recollection-Based Memory Over a Seven-Day Period in Younger and Older Adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32038382


|keywords=* aging
* recollection and familiarity
* retrieval practice
* temporal dynamics
* testing effect
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990689
}}
{{medline-entry
|title=A Comparison of Heart Rate Training Load and Perceptual Effort Between Masters and Young Cyclists
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32000141

|mesh-terms=* Adult
* Aging
* Bicycling
* Heart Rate
* High-Intensity Interval Training
* Humans
* Middle Aged
* Perception
* Physical Exertion
|keywords=* age
* endurance training
* high-intensity interval training
* older athlete
|full-text-url=https://sci-hub.do/10.1123/ijspp.2019-0413
}}
{{medline-entry
|title=Retinal Pigment Epithelial Cells: The Unveiled Component in the Etiology of Prpf Splicing Factor-Associated Retinitis Pigmentosa.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31884616

|mesh-terms=* Animals
* Circadian Rhythm
* Epithelial Cells
* Eye Proteins
* Humans
* Mice
* Phagocytosis
* Photoreceptor Cells, Vertebrate
* RNA Splicing Factors
* Retinal Pigment Epithelium
* Retinitis Pigmentosa
|keywords=* Aging
* Cellular stress
* Circadian rhythm
* Metabolism
* PRPF
* Phagocytosis
* Retinal pigment epithelium
* Retinitis pigmentosa
* Splicing factors
|full-text-url=https://sci-hub.do/10.1007/978-3-030-27378-1_37
}}
{{medline-entry
|title=AMPK May Play an Important Role in the Retinal Metabolic Ecosystem.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31884657

|mesh-terms=* AMP-Activated Protein Kinases
* Animals
* DNA Damage
* DNA, Mitochondrial
* Disease Models, Animal
* Gene Dosage
* Metformin
* Mice
* Oxidative Stress
* Retina
* Retinal Degeneration
* Retinitis Pigmentosa
|keywords=* AMPK
* Adenosine monophosphate-activated protein kinase
* Aging
* Glycolysis
* Metabolism
* Neuroprotection
* Retina
|full-text-url=https://sci-hub.do/10.1007/978-3-030-27378-1_78
}}
{{medline-entry
|title=Stem cell-derived retinal pigment epithelium from patients with age-related macular degeneration exhibit reduced metabolism and matrix interactions.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31840941


|keywords=* Bruch's membrane
* age-related macular degeneration
* aging
* induced pluripotent stem cells
* nonenzymatic nitration
* retinal pigment epithelium
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031648
}}
{{medline-entry
|title=Elovanoids counteract oligomeric β-amyloid-induced gene expression and protect photoreceptors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31712409

|mesh-terms=* Amyloid beta-Peptides
* Animals
* Apoptosis
* Autophagy
* Cells, Cultured
* Docosahexaenoic Acids
* Extracellular Matrix
* Fatty Acids, Omega-3
* Gene Expression Regulation
* Humans
* Male
* Mice, Inbred C57BL
* Mice, Transgenic
* Photoreceptor Cells
* Retina
* Retinal Pigment Epithelium
* Young Adult
|keywords=* SASP
* age-related macular degeneration
* p16
* retinal pigment epithelial cells
* senescence gene program
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883841
}}
{{medline-entry
|title=Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31699817

|mesh-terms=* Aging
* Animals
* Basement Membrane
* Bruch Membrane
* Exocytosis
* Humans
* Lysosomal-Associated Membrane Protein 2
* Lysosomes
* Macular Degeneration
* Mice
* Mice, Knockout
* Phagocytosis
* Retina
* Retinal Pigment Epithelium
|keywords=* LAMP2
* aging
* lysosome
* retinal degeneration
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876195
}}
{{medline-entry
|title=Age, lipofuscin and melanin oxidation affect fundus near-infrared autofluorescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31648994

|mesh-terms=* Age Factors
* Animals
* Biomarkers
* Choroid
* Disease Models, Animal
* Female
* Fluorescein Angiography
* Fundus Oculi
* Humans
* Lipofuscin
* Macular Degeneration
* Male
* Melanins
* Melanosomes
* Mice
* Mice, Knockout
* Optical Imaging
* Oxidation-Reduction
* Oxidative Stress
* Protein Transport
* Retinal Pigment Epithelium
* Tomography, Optical Coherence
|keywords=* Aging
* Lipofuscin
* Melanin
* Melanolipofuscin
* Oxidative stress
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838394
}}
{{medline-entry
|title=Relevance of working memory for reinforcement learning in older adults varies with timescale of learning.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31544587


|keywords=* Aging
* computational modeling
* individual differences
* reinforcement learning
* working memory
|full-text-url=https://sci-hub.do/10.1080/13825585.2019.1664389
}}
{{medline-entry
|title=Expression and Function of Mas-Related G Protein-Coupled Receptor D and Its Ligand Alamandine in Retina.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31392515

|mesh-terms=* Aging
* Angiotensin II
* Animals
* Cells, Cultured
* Electroretinography
* Humans
* Ligands
* Lipopolysaccharides
* Mice, Inbred C57BL
* Mice, Knockout
* Oligopeptides
* Rats
* Reactive Oxygen Species
* Receptors, G-Protein-Coupled
* Retina
|keywords=* Alamandine
* Angiotensin-(1–7)
* Mas-related G protein-coupled receptor D
* Rennin-angiotensin system
* Retina
|full-text-url=https://sci-hub.do/10.1007/s12035-019-01716-4
}}