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Aging genes 60-99
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==ATM== * {{medline-title |title=S[[ATM]]F Suppresses the Premature Senescence Phenotype of the [[ATM]] Loss-of-Function Mutant and Improves Its Fertility in [i]Arabidopsis[/i]. |date=30.10.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143308 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662627 }} * {{medline-title |title=[[ATM]] mediated-p53 signaling pathway forms a novel axis for senescence control. |date=11.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32949791 |full-text-url=https://sci-hub.do/10.1016/j.mito.2020.09.002 }} * {{medline-title |title=Non-canonical [[ATM]]/MRN activities temporally define the senescence secretory program. |date=05.10.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32785991 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534619 }} * {{medline-title |title=[[ATM]] is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging. |date=22.03.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32201398 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138542 }} * {{medline-title |title=[[ATM]] suppresses leaf senescence triggered by DNA double-strand break through epigenetic control of senescence-associated genes in Arabidopsis. |date=07.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32163596 |full-text-url=https://sci-hub.do/10.1111/nph.16535 }} * {{medline-title |title=Glioblastoma Cells Do Not Affect Axitinib-Dependent Senescence of HUVECs in a Transwell Coculture Model. |date=21.02.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32098270 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073100 }} * {{medline-title |title=Declining BRCA-Mediated DNA Repair in Sperm Aging and its Prevention by Sphingosine-1-Phosphate. |date=03.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31916095 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065969 }} * {{medline-title |title=BRCA-related [[ATM]]-mediated DNA double-strand break repair and ovarian aging. |date=01.01.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31822904 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935693 }} * {{medline-title |title=[[ATM]] Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31781094 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856652 }} * {{medline-title |title=SMG1 heterozygosity exacerbates haematopoietic cancer development in Atm null mice by increasing persistent DNA damage and oxidative stress. |date=12.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31565865 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6850945 }} * {{medline-title |title=LncRNA RP11-670E13.6, interacted with hnRNPH, delays cellular senescence by sponging microRNA-663a in UVB damaged dermal fibroblasts. |date=23.08.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31444317 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738423 }} * {{medline-title |title=Tel1/[[ATM]] Signaling to the Checkpoint Contributes to Replicative Senescence in the Absence of Telomerase. |date=10.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31391264 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781906 }} * {{medline-title |title=Curcumin induces multiple signaling pathways leading to vascular smooth muscle cell senescence. |date=12.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31372798 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790191 }} * {{medline-title |title=Long-term culture of mesenchymal stem cells impairs [[ATM]]-dependent recognition of DNA breaks and increases genetic instability. |date=29.07.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31358047 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664790 }} * {{medline-title |title=Genetic background, epigenetic factors and dietary interventions which influence human longevity. |date=10.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31309340 |full-text-url=https://sci-hub.do/10.1007/s10522-019-09824-3 }} * {{medline-title |title=Repair-independent functions of DNA-PKcs protect irradiated cells from mitotic slippage and accelerated senescence. |date=01.07.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31189537 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6633392 }} * {{medline-title |title=Meeting report of the 14th Japan-Korea joint symposium on cancer and aging research: current status of translational research and approaches to precision medicine. |date=05.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30859317 |full-text-url=https://sci-hub.do/10.1007/s00432-019-02887-2 }} * {{medline-title |title=Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30798935 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043287 }} * {{medline-title |title=Alleviation of Senescence via [[ATM]] Inhibition in Accelerated Aging Models. |date=31.03.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30726661 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449716 }} * {{medline-title |title=Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence. |date=01.05.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30735837 |full-text-url=https://sci-hub.do/10.1016/j.freeradbiomed.2019.02.005 }} * {{medline-title |title=Genomic insult oriented mitochondrial instability and proliferative hindrance in the bone marrow of aplastic mice including stem/progenitor population. |date=04.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30683472 |full-text-url=https://sci-hub.do/10.1016/j.prp.2019.01.028 }} * {{medline-title |title=N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/[[ATM]] pathway. |date=18.01.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30657058 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337850 }} * {{medline-title |title=Hydrogen Indirectly Suppresses Increases in Hydrogen Peroxide in Cytoplasmic Hydroxyl Radical-Induced Cells and Suppresses Cellular Senescence. |date=21.01.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30669692 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359316 }} * {{medline-title |title=Low dose dinaciclib enhances doxorubicin-induced senescence in myeloma RPMI8226 cells by transformation of the p21 and p16 pathways. |date=11.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30405800 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202540 }} * {{medline-title |title=The activated DNA double-strand break repair pathway in cumulus cells from aging patients may be used as a convincing predictor of poor outcomes after in vitro fertilization-embryo transfer treatment. |date=2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30235328 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147527 }} * {{medline-title |title=Epigallocatechin-3-gallate and BIX-01294 have different impact on epigenetics and senescence modulation in acute and chronic myeloid leukemia cells. |date=05.11.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30194939 |full-text-url=https://sci-hub.do/10.1016/j.ejphar.2018.09.005 }} * {{medline-title |title=The SCF ubiquitin ligase complex mediates degradation of the tumor suppressor [[FBXO31]] and thereby prevents premature cellular senescence. |date=19.10.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30171069 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200945 }} * {{medline-title |title=Defenses against Pro-oxidant Forces - Maintenance of Cellular and Genomic Integrity and Longevity. |date=10.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30040046 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203329 }} * {{medline-title |title=The ING1a model of rapid cell senescence. |date=01.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29928906 |full-text-url=https://sci-hub.do/10.1016/j.mad.2018.06.004 }} * {{medline-title |title=Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo. |date=08.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29923368 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052487 }} * {{medline-title |title=Boosting [[ATM]] activity alleviates aging and extends lifespan in a mouse model of progeria. |date=02.05.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29717979 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957528 }} * {{medline-title |title=Inflammation, a significant player of Ataxia-Telangiectasia pathogenesis? |date=07.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29582093 |full-text-url=https://sci-hub.do/10.1007/s00011-018-1142-y }} * {{medline-title |title=Transcriptional Repression of High-Mobility Group Box 2 by p21 in Radiation-Induced Senescence. |date=30.04.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29487276 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935093 }} * {{medline-title |title=Senescence-messaging secretome factors trigger premature senescence in human endometrium-derived stem cells. |date=19.02.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29397942 |full-text-url=https://sci-hub.do/10.1016/j.bbrc.2018.01.163 }} * {{medline-title |title=Bisphenol A induces DSB-[[ATM]]-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. |date=04.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29275510 |full-text-url=https://sci-hub.do/10.1007/s00204-017-2150-3 }} * {{medline-title |title=Global mapping of transcription factor motifs in human aging. |date=2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29293662 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749797 }} * {{medline-title |title=Ataxia-Telangiectasia Mutated Modulation of Carbon Metabolism in Cancer. |date=2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29238697 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712564 }} * {{medline-title |title=DNA damage, metabolism and aging in pro-inflammatory T cells: Rheumatoid arthritis as a model system. |date=05.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29101015 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871568 }} * {{medline-title |title=Genetic interrogation of replicative senescence uncovers a dual role for [[USP28]] in coordinating the p53 and [[GATA4]] branches of the senescence program. |date=01.10.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29089421 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710139 }} * {{medline-title |title=A lowered 26S proteasome activity correlates with mantle lymphoma cell lines resistance to genotoxic stress. |date=10.08.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28797244 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553741 }} * {{medline-title |title=Haplodeficiency of Ataxia Telangiectasia Mutated Accelerates Heart Failure After Myocardial Infarction. |date=19.07.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28724653 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586323 }} * {{medline-title |title=iTRAQ-based proteomic profiling of granulosa cells from lamb and ewe after superstimulation. |date=01.10.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28708522 |full-text-url=https://sci-hub.do/10.1016/j.theriogenology.2017.06.014 }} * {{medline-title |title=[The Role of DNA Double-strain Damage Repairing Mechanisms in Diabetic Atheroscolersis]. |date=03.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28612525 }} * {{medline-title |title=The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State? |date=2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28436392 |full-text-url=https://sci-hub.do/10.3233/JAD-161221 }} * {{medline-title |title=Chemical screening identifies [[ATM]] as a target for alleviating senescence. |date=06.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28346404 |full-text-url=https://sci-hub.do/10.1038/nchembio.2342 }} * {{medline-title |title=Age and Adaptation: Stronger Decision Updating about Real World Risks in Older Age. |date=09.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28095602 |full-text-url=https://sci-hub.do/10.1111/risa.12710 }} * {{medline-title |title=Accumulation of spontaneous γH2AX foci in long-term cultured mesenchymal stromal cells. |date=11.12.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27959319 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270682 }} * {{medline-title |title=Calcium alterations signal either to senescence or to autophagy induction in stem cells upon oxidative stress. |date=08.12.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27941214 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270676 }} * {{medline-title |title=Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage. |date=04.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27895165 |full-text-url=https://sci-hub.do/10.1189/jlb.4VMA0716-316R }} * {{medline-title |title=[[ATM]]-ROS-iNOS axis regulates nitric oxide mediated cellular senescence. |date=01.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27845209 |full-text-url=https://sci-hub.do/10.1016/j.bbamcr.2016.11.008 }} * {{medline-title |title=NAD Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. |date=11.10.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27732836 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777858 }} * {{medline-title |title=Overcoming [[ATM]] Deficiency by Activating the NAD /[[SIRT1]] Axis. |date=11.10.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27732834 |full-text-url=https://sci-hub.do/10.1016/j.cmet.2016.09.019 }} * {{medline-title |title=Perturbed hematopoiesis in mice lacking [[ATM]]IN. |date=20.10.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27581360 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147016 }} * {{medline-title |title=BRCA-1 Gene Expression and Comparative Proteomic Profile of Primordial Follicles from Young and Adult Buffalo (Bubalus bubalis) Ovaries. |date=03.04.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27552356 |full-text-url=https://sci-hub.do/10.1080/10495398.2016.1210613 }} * {{medline-title |title=[[IFI16]], an amplifier of DNA-damage response: Role in cellular senescence and aging-associated inflammatory diseases. |date=07.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27063514 |full-text-url=https://sci-hub.do/10.1016/j.arr.2016.04.002 }} * {{medline-title |title=Transcription factor Sp1 prevents TRF2(ΔBΔM)-induced premature senescence in human diploid fibroblasts. |date=03.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26906205 |full-text-url=https://sci-hub.do/10.1007/s11010-016-2672-7 }} * {{medline-title |title=Mitochondria are required for pro-ageing features of the senescent phenotype. |date=01.04.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26848154 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818766 }} * {{medline-title |title=Induction of DNA double-strand breaks and cellular senescence by human respiratory syncytial virus. |date=18.05.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26809688 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871660 }} * {{medline-title |title=A gain-of-function senescence bypass screen identifies the homeobox transcription factor [[DLX2]] as a regulator of [[ATM]]-p53 signaling. |date=01.02.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26833729 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743059 }} * {{medline-title |title=Tetraploidization or autophagy: The ultimate fate of senescent human endometrial stem cells under [[ATM]] or p53 inhibition. |date=2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26636375 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825783 }} * {{medline-title |title=Health risks for ataxia-telangiectasia mutated heterozygotes: a systematic review, meta-analysis and evidence-based guideline. |date=08.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26662178 |full-text-url=https://sci-hub.do/10.1111/cge.12710 }} * {{medline-title |title=The DNA damage response induces inflammation and senescence by inhibiting autophagy of [[GATA4]]. |date=25.09.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26404840 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942138 }} * {{medline-title |title=BRCA Mutations, DNA Repair Deficiency, and Ovarian Aging. |date=09.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26224004 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710189 }} * {{medline-title |title=[Advances of Research on Ataxia Telangiectasia Mutated Gene and Risk Factors of Cardiovascular Disease]. |date=04.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26211275 }} * {{medline-title |title=Requirement of [[ATR]] for maintenance of intestinal stem cells in aging Drosophila. |date=05.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26000719 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468312 }} * {{medline-title |title=Evidence of cellular senescence during the development of estrogen-induced pituitary tumors. |date=06.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25792544 |full-text-url=https://sci-hub.do/10.1530/ERC-14-0333 }} * {{medline-title |title=Temporally distinct roles of [[ATM]] and ROS in genotoxic-stress-dependent induction and maintenance of cellular senescence. |date=15.01.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25416819 |full-text-url=https://sci-hub.do/10.1242/jcs.159517 }} * {{medline-title |title=Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation. |date=05.12.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25336634 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256366 }} * {{medline-title |title=A switch-like dynamic mechanism for the initiation of replicative senescence. |date=28.11.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25315415 |full-text-url=https://sci-hub.do/10.1016/j.febslet.2014.09.043 }} * {{medline-title |title=Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells. |date=01.08.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24858802 |full-text-url=https://sci-hub.do/10.1016/j.bcp.2014.05.009 }} * {{medline-title |title=Fullerenol protects retinal pigment epithelial cells from oxidative stress-induced premature senescence via activating [[SIRT1]]. |date=20.05.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24845634 |full-text-url=https://sci-hub.do/10.1167/iovs.13-13732 }} * {{medline-title |title=Essential role for the TRF2 telomere protein in adult skin homeostasis. |date=08.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24725274 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326939 }} * {{medline-title |title=Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication. |date=2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24552809 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984300 }} * {{medline-title |title=Molecular characterization of collaborator of ARF ([[CARF]]) as a DNA damage response and cell cycle checkpoint regulatory protein. |date=01.04.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24485912 |full-text-url=https://sci-hub.do/10.1016/j.yexcr.2014.01.022 }} * {{medline-title |title=The thyroid hormone receptor β induces DNA damage and premature senescence. |date=06.01.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24395638 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882795 }} * {{medline-title |title=Novel delivery system for T-oligo using a nanocomplex formed with an alpha helical peptide for melanoma therapy. |date=2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24391441 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879016 }}
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