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Aging genes 60-69
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==IGF1== * {{medline-title |title=Impact of Aging on the Phenotype of Invariant Natural Killer T Cells in Mouse Thymus. |date=2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33193368 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662090 }} * {{medline-title |title=Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice. |date=11.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33105070 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681063 }} * {{medline-title |title=17α-estradiol modulates [[IGF1]] and hepatic gene expression in a sex-specific manner. |date=28.08.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32857104 |full-text-url=https://sci-hub.do/10.1093/gerona/glaa215 }} * {{medline-title |title=Voluntary exercise training attenuated the middle-aged maturity-induced cardiac apoptosis. |date=15.10.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32781061 |full-text-url=https://sci-hub.do/10.1016/j.lfs.2020.118187 }} * {{medline-title |title=Age-at-onset-dependent effects of sulfur amino acid restriction on markers of growth and stress in male F344 rats. |date=07.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32573078 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426777 }} * {{medline-title |title=Muscle-dependent regulation of adipose tissue function in long-lived growth hormone-mutant mice. |date=28.05.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32464603 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288969 }} * {{medline-title |title=Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides. |date=06.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32399807 |full-text-url=https://sci-hub.do/10.1007/s11033-020-05506-3 }} * {{medline-title |title=Pan-mammalian analysis of molecular constraints underlying extended lifespan. |date=11.02.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32043462 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012612 }} * {{medline-title |title=17α-Estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates. |date=01.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31698046 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911620 }} * {{medline-title |title=Targeting p16-induced senescence prevents cigarette smoke-induced emphysema by promoting [[IGF1]]/Akt1 signaling in mice. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31428695 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6689060 }} * {{medline-title |title=Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged [[APP]] /PS1 Transgenic Mice. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31417357 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6682662 }} * {{medline-title |title=Reducing [[INS]]-[[IGF1]] signaling protects against non-cell autonomous vesicle rupture caused by [[SNCA]] spreading. |date=05.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31354022 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144869 }} * {{medline-title |title=Are There Common Mechanisms Between the Hutchinson-Gilford Progeria Syndrome and Natural Aging? |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31156709 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529819 }} * {{medline-title |title=Lactoferrin ameliorates aging-suppressed osteogenesis via [[IGF1]] signaling. |date=07.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31125976 |full-text-url=https://sci-hub.do/10.1530/JME-19-0003 }} * {{medline-title |title=[i][[TP53]][/i] Tumor-suppressor Gene Plays a Key Role in [[IGF1]] Signaling Pathway Related to the Aging of Human Melanocytes. |date=05.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31092438 |full-text-url=https://sci-hub.do/10.21873/anticanres.13363 }} * {{medline-title |title=Involvement of insulin receptor substrates in cognitive impairment and Alzheimer's disease. |date=08.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30964050 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524492 }} * {{medline-title |title=In mice transgenic for [[IGF1]] under keratin-14 promoter, lifespan is decreased and the rates of aging and thymus involution are accelerated. |date=13.04.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30981207 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503882 }} * {{medline-title |title=[[IGF1]] Gene Therapy Modifies Microglia in the Striatum of Senile Rats. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30890930 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411822 }} * {{medline-title |title=Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease. |date=05.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30684534 |full-text-url=https://sci-hub.do/10.1016/j.exger.2019.01.020 }} * {{medline-title |title=Growth signaling and longevity in mouse models. |date=01.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30545442 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386229 }} * {{medline-title |title=IGF-1 Gene Therapy as a Potentially Useful Therapy for Spontaneous Prolactinomas in Senile Rats. |date=2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30198429 |full-text-url=https://sci-hub.do/10.2174/1566523218666180905170020 }} * {{medline-title |title=A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup. |date=12.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30151729 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294728 }} * {{medline-title |title=Matrine induces senescence of human glioblastoma cells through suppression of the [[IGF1]]/PI3K/AKT/p27 signaling pathway. |date=09.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30079478 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143938 }} * {{medline-title |title=Composition and richness of the serum microbiome differ by age and link to systemic inflammation. |date=06.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29869736 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060185 }} * {{medline-title |title=40 YEARS of [[IGF1]]: [[IGF1]]: the Jekyll and Hyde of the aging brain. |date=07.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29739805 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988994 }} * {{medline-title |title=De-silencing [i]Grb10[/i] contributes to acute ER stress-induced steatosis in mouse liver. |date=05.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29555819 |full-text-url=https://sci-hub.do/10.1530/JME-18-0018 }} * {{medline-title |title=Long-lived rodents reveal signatures of positive selection in genes associated with lifespan. |date=03.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29570707 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884551 }} * {{medline-title |title=Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans. |date=03.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29522556 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862515 }} * {{medline-title |title=Withanolide A extends the lifespan in human [[EGFR]]-driven cancerous Caenorhabditis elegans. |date=04.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29427754 |full-text-url=https://sci-hub.do/10.1016/j.exger.2018.02.004 }} * {{medline-title |title=Caloric restriction stabilizes body weight and accelerates behavioral recovery in aged rats after focal ischemia. |date=12.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28961383 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676058 }} * {{medline-title |title=Molecular signatures of longevity: Insights from cross-species comparative studies. |date=10.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28800931 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807068 }} * {{medline-title |title=The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover. |date=20.04.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28431247 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406386 }} * {{medline-title |title=Life-span Extension With Reduced Somatotrophic Signaling: Moderation of Aging Effect by Signal Type, Sex, and Experimental Cohort. |date=09.11.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28207064 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861954 }} * {{medline-title |title=Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging. |date=2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28203146 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5285390 }} * {{medline-title |title=Changes in Communication between Muscle Stem Cells and their Environment with Aging. |date=02.09.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27858742 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240546 }} * {{medline-title |title=Role of Bone Marrow Maturity, Insulin-Like Growth Factor 1 Receptor, and Forkhead Box Protein N1 in Thymic Involution and Rejuvenation. |date=10.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27145342 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097038 }} * {{medline-title |title=Effects of Metabolic Programming on Juvenile Play Behavior and Gene Expression in the Prefrontal Cortex of Rats. |date=2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26967530 |full-text-url=https://sci-hub.do/10.1159/000444015 }} * {{medline-title |title=Apoptosis during embryonic tissue remodeling is accompanied by cell senescence. |date=11.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26568417 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694067 }} * {{medline-title |title=Telomerase activity promotes osteoblast differentiation by modulating IGF-signaling pathway. |date=12.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26260615 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602053 }} * {{medline-title |title=Exercise does not enhance aged bone's impaired response to artificial loading in C57Bl/6 mice. |date=12.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26142929 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652609 }} * {{medline-title |title=Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the cortex. |date=07.07.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26100875 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500222 }} * {{medline-title |title=Aerobic Exercise Recovers Disuse-induced Atrophy Through the Stimulus of the LRP130/[[PGC]]-1α Complex in Aged Rats. |date=05.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25991827 |full-text-url=https://sci-hub.do/10.1093/gerona/glv064 }} * {{medline-title |title=Insulin-like growth factor 1, glycation and bone fragility: implications for fracture resistance of bone. |date=2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25629402 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309541 }} * {{medline-title |title=Comparison of rapamycin schedules in mice on high-fat diet. |date=2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25485580 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614913 }} * {{medline-title |title=Growth hormone abolishes beneficial effects of calorie restriction in long-lived Ames dwarf mice. |date=10.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25152388 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252511 }} * {{medline-title |title=A randomised controlled trial evaluating [[IGF1]] titration in contrast to current GH dosing strategies in children born small for gestational age: the North European Small-for-Gestational-Age Study. |date=10.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25080293 |full-text-url=https://sci-hub.do/10.1530/EJE-14-0419 }} * {{medline-title |title=Human [[IGF1]] regulates midgut oxidative stress and epithelial homeostasis to balance lifespan and Plasmodium falciparum resistance in Anopheles stephensi. |date=06.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24968248 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072789 }} * {{medline-title |title=Could different treatment approaches in acromegaly influence life expectancy? A comparative study between Bulgaria and Campania (Italy). |date=08.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24878680 |full-text-url=https://sci-hub.do/10.1530/EJE-13-1022 }} * {{medline-title |title=Insulin and insulin-like growth factor receptors in the brain: physiological and pathological aspects. |date=12.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24529663 |full-text-url=https://sci-hub.do/10.1016/j.euroneuro.2014.01.020 }} * {{medline-title |title=Selective manipulation of aging: a novel strategy for the treatment of neurodegenerative disorders. |date=13.02.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24526357 |full-text-url=https://sci-hub.do/10.4414/smw.2014.13917 }} * {{medline-title |title=Genes of human longevity: an endless quest? |date=2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24350927 |full-text-url=https://sci-hub.do/10.2174/1570161111666131219110301 }} * {{medline-title |title=A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity. |date=02.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24261972 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326862 }} * {{medline-title |title=Serum levels of bioactive [[IGF1]] and physiological markers of ageing in healthy adults. |date=02.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24179101 |full-text-url=https://sci-hub.do/10.1530/EJE-13-0661 }} * {{medline-title |title=Pre- and postnatal nutrition in sheep affects β-cell secretion and hypothalamic control. |date=11.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24096964 |full-text-url=https://sci-hub.do/10.1530/JOE-13-0099 }} * {{medline-title |title=Perturbations to the [[IGF1]] growth pathway and adult energy homeostasis following disruption of mouse chromosome 12 imprinting. |date=01.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24034272 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992899 }} * {{medline-title |title=Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1. |date=01.11.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23958494 |full-text-url=https://sci-hub.do/10.1016/j.taap.2013.07.024 }} * {{medline-title |title=Monocentric study of 112 consecutive patients with childhood onset GH deficiency around and after transition. |date=11.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23939920 |full-text-url=https://sci-hub.do/10.1530/EJE-13-0572 }} * {{medline-title |title=Signalling pathways regulating muscle mass in ageing skeletal muscle: the role of the [[IGF1]]-Akt-mTOR-FoxO pathway. |date=06.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23686362 |full-text-url=https://sci-hub.do/10.1007/s10522-013-9432-9 }} * {{medline-title |title=Elevated [[IGF1]] in clinical opiate dependence. |date=2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23524620 }} * {{medline-title |title=Integrating metabolism and longevity through insulin and [[IGF1]] signaling. |date=03.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23391244 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982789 }} * {{medline-title |title=Adiponectin in mice with altered GH action: links to insulin sensitivity and longevity? |date=03.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23261955 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756886 }} * {{medline-title |title=Serum [[IGF1]], metabolic syndrome, and incident cardiovascular disease in older people: a population-based study. |date=03.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23233113 |full-text-url=https://sci-hub.do/10.1530/EJE-12-0784 }}
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