Редактирование: Публикации о генах и старении (titles) (раздел)

==MSC==

{{medline-entry
|title=Rejuvenation of Senescent Endothelial Progenitor Cells by Extracellular Vesicles Derived From Mesenchymal Stromal Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33294742


|keywords=* BM, bone marrow
* CVD, cardiovascular disease
* EC, endothelial cell
* EPC, endothelial progenitor cell
* EV, extracellular vesicle
* FBS, fetal bovine serum
* MEM, minimum essential medium
* MI, myocardial infarction
* MSC, mesenchymal stromal cell
* NTA, nanotracking analysis
* PBS, phosphate-buffered saline
* TEV, tailored extracellular vesicle
* VEGF, vascular endothelial growth factor
* acellular
* angiogenesis
* extracellular vesicles
* lin− BMC, lineage negative bone marrow cell
* miR, microRNA
* qPCR, quantitative transcription polymerase chain reaction
* regeneration
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7691285
}}
{{medline-entry
|title=Extracellular vesicles derived from bone marrow mesenchymal stem cells enhance myelin maintenance after cortical injury in aged rhesus monkeys.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33264634


|keywords=* Aging
* Cortical injury
* Extracellular vesicles
* Monkeys
* Myelin
* Non-human primates
* Oligodendrocytes
* Stroke
* White matter
|full-text-url=https://sci-hub.do/10.1016/j.expneurol.2020.113540
}}
{{medline-entry
|title=TPP1 Enhances the Therapeutic Effects of Transplanted Aged Mesenchymal Stem Cells in Infarcted Hearts via the MRE11/AKT Pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33195247


|keywords=* DNA repair
* aging
* myocardial infarction
* stem cells therapy
* telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658181
}}
{{medline-entry
|title=Aging-Affected [[MSC]] Functions and Severity of Periodontal Tissue Destruction in a Ligature-Induced Mouse Periodontitis Model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33143068


|keywords=* aging
* bone resorption
* immunomodulation
* mesenchymal stem cell
* periodontitis
* tissue destruction
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663404
}}
{{medline-entry
|title=Human placenta-derived mesenchymal stem cells stimulate ovarian function via miR-145 and bone morphogenetic protein signaling in aged rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33153492


|keywords=* Aging
* Follicular development
* Hormone biosynthesis
* Primordial follicle activation
* Stem cell therapy
* miR-145
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7643421
}}
{{medline-entry
|title=Mesenchymal Stromal Cells as Critical Contributors to Tissue Regeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33102483


|keywords=* adult stem cells
* aging
* mesenchymal stromal cells (MSC)
* regenerative medicine
* stem cell niche
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546871
}}
{{medline-entry
|title=The biology of human hair greying.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32965076


|keywords=* ageing
* endocrine
* graying
* melanin
* senescence
|full-text-url=https://sci-hub.do/10.1111/brv.12648
}}
{{medline-entry
|title=[i]Tsc1[/i] Regulates the Proliferation Capacity of Bone-Marrow Derived Mesenchymal Stem Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32927859


|keywords=* TSC1
* mammalian target of rapamycin (mTOR)
* mesenchymal stem cell
* senescence
* stem cell proliferation
* tuberous sclerosis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565438
}}
{{medline-entry
|title=The role of mitochondrial dysfunction in mesenchymal stem cell senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32803322


|keywords=* Mesenchymal stem cells
* Mitochondrial dysfunction
* Mitophagy
* Reactive oxygen species
* Senescence
|full-text-url=https://sci-hub.do/10.1007/s00441-020-03272-z
}}
{{medline-entry
|title=Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem/stromal cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32787856


|keywords=* EV
* MSC
* Metabolic syndrome
* RNA-sequencing
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7425605
}}
{{medline-entry
|title=Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32699947


|keywords=* Aging diseases
* Conditioned medium
* Diabetes
* Exosomes
* Extracellular vesicles
* Lupus
* Regenerative medicine
* Secretome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375036
}}
{{medline-entry
|title=Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of [[MSC]]s.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32660632


|keywords=* Aging
* Heterochromatin
* MSC senescence
* mTORC1/p70S6K
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359252
}}
{{medline-entry
|title=Increased cellular senescence in the murine and human stenotic kidney: Effect of mesenchymal stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32657444


|keywords=* cellular senescence
* exosomes
* kidney
* mesenchymal stem cells
* renal artery obstruction
|full-text-url=https://sci-hub.do/10.1002/jcp.29940
}}
{{medline-entry
|title=Intrinsic Type 1 Interferon (IFN1) Profile of Uncultured Human Bone Marrow CD45 CD271  Multipotential Stromal Cells (BM-[[MSC]]s): The Impact of Donor Age, Culture Expansion and IFNα and IFNβ Stimulation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32679782


|keywords=* aging
* bone marrow
* mesenchymal stromal cells
* senescence
* type 1 interferon
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399891
}}
{{medline-entry
|title=Facial rejuvenation using stem cell conditioned media combined with skin needling: A split-face comparative study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32623814


|keywords=* amniotic fluid stem cells products
* dermaroller
* facial aging
* skin needling
|full-text-url=https://sci-hub.do/10.1111/jocd.13594
}}
{{medline-entry
|title=Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32582691


|keywords=* autophagy
* mesenchymal stem cells
* mitochondrial
* rejuvenation
* senescence
* telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283395
}}
{{medline-entry
|title=The changing epigenetic landscape of Mesenchymal Stem/Stromal Cells during aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32445894


|keywords=* Aging
* DNA methylation
* Epigenetics
* Histome modifications
* MSC
* Mesenchymal Stem/Stromal Cells
* Skeleton
* miRNA
|full-text-url=https://sci-hub.do/10.1016/j.bone.2020.115440
}}
{{medline-entry
|title=Dual Role of Autophagy in Regulation of Mesenchymal Stem Cell Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32391362


|keywords=* SASP
* general autophagy
* mesenchymal stem cell
* selective autophagy
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193103
}}
{{medline-entry
|title=Molecular Aspects of Adipose-Derived Stromal Cell Senescence in a Long-Term Culture: A Potential Role of Inflammatory Pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32314614


|keywords=* adipose-derived stromal/stem cell
* aging
* gene expression
* long-term culture
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7586277
}}
{{medline-entry
|title=Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32274385


|keywords=* adipose tissue
* cellular dysfunction
* cellular senescence
* mesenchymal stem cells
* obesity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113401
}}
{{medline-entry
|title=miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32196916


|keywords=* mesenchymal stem cells
* miR-155-5p
* myocardial infarction
* rejuvenation
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189985
}}
{{medline-entry
|title=Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32154253


|keywords=* aging
* clinical translation
* extracellular vesicles
* mesenchymal stem cells
* regenerative medicine
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047768
}}
{{medline-entry
|title=Molecular Mechanisms Contributing to Mesenchymal Stromal Cell Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32098040


|keywords=* MSC senescence
* in vitro aging
* in vivo aging
* mesenchymal stem/stromal cells (MSC)
* rejuvenating strategies
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072652
}}
{{medline-entry
|title=Inhibition of DNA Methyltransferase by RG108 Promotes Pluripotency-Related Character of Porcine Bone Marrow Mesenchymal Stem Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32125888


|keywords=* RG108
* apoptosis
* pluripotency
* porcine bone marrow mesenchymal stem cells
* senescence
|full-text-url=https://sci-hub.do/10.1089/cell.2019.0060
}}
{{medline-entry
|title=Extracellular Vesicles of Stem Cells to Prevent BRONJ.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32119600


|keywords=* bisphosphonate-associated osteonecrosis of the jaw
* cellular senescence
* exosomes
* mesenchymal stem cells
* wound healing
* zoledronic acid
|full-text-url=https://sci-hub.do/10.1177/0022034520906793
}}
{{medline-entry
|title=Ginsenoside Rg1 as an Effective Regulator of Mesenchymal Stem Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32038244


|keywords=* apoptosis
* differentiation
* ginsenoside Rg1
* mesenchymal stem cells
* preclinical study
* proliferation
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989539
}}
{{medline-entry
|title=The Importance of Stem Cell Senescence in Regenerative Medicine.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32026416


|keywords=* Aging
* Mesenchymal stem cell
* Regenerative medicine
|full-text-url=https://sci-hub.do/10.1007/5584_2020_489
}}
{{medline-entry
|title=Control of mesenchymal stem cell biology by histone modifications.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32025282


|keywords=* Cell biology
* Cell differentiation
* Cellular senescence
* Epigenetics
* Histone modifications
* Mesenchymal stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996187
}}
{{medline-entry
|title=Impact of mesenchymal stem cell senescence on inflammaging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31964472

|mesh-terms=* Aging
* Cellular Senescence
* Cytokines
* Hematopoiesis
* Humans
* Immunomodulation
* Immunosenescence
* Inflammation
* Macrophages
* Mesenchymal Stem Cells

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061209
}}
{{medline-entry
|title=Late Rescue Therapy with Cord-Derived Mesenchymal Stromal Cells for Established Lung Injury in Experimental Bronchopulmonary Dysplasia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31918630


|keywords=* COPD
* aging
* lung
* newborn
* regenerative medicine
* stem cells
|full-text-url=https://sci-hub.do/10.1089/scd.2019.0116
}}
{{medline-entry
|title=Low-Level Radiofrequency Exposure Does Not Induce Changes in [[MSC]] Biology: An in vitro Study for the Prevention of NIR-Related Damage.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31908499


|keywords=* 169 MHz
* CFU
* senescence
* stem cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927227
}}
{{medline-entry
|title=Macrophage migration inhibitory factor rejuvenates aged human mesenchymal stem cells and improves myocardial repair.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31881006

|mesh-terms=* Adolescent
* Aged
* Aged, 80 and over
* Aging
* Animals
* Animals, Newborn
* Cellular Senescence
* Humans
* Macrophage Migration-Inhibitory Factors
* Mesenchymal Stem Cell Transplantation
* Mesenchymal Stem Cells
* Myocardial Infarction
* Myocardium
* Myocytes, Cardiac
* Rats
* Rats, Sprague-Dawley
* Young Adult
|keywords=* macrophage migration inhibitory factor
* mesenchymal stem cells
* myocardial infarction
* rejuvenation
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949107
}}
{{medline-entry
|title=Influence of olive oil and its components on mesenchymal stem cell biology.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31875868


|keywords=* Aging
* Cellular differentiation
* Cellular niche
* Mediterranean diet
* Mesenchymal stem cells
* Olive oil
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904865
}}
{{medline-entry
|title=Epigenetic Regulation of Mesenchymal Stem Cell Homeostasis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31866188


|keywords=* aging
* epigenetics
* fate decision
* mesenchymal stem cells
* pathogenesis
* regeneration
|full-text-url=https://sci-hub.do/10.1016/j.tcb.2019.11.006
}}
{{medline-entry
|title=Mesenchymal Stem Cells: Allogeneic [[MSC]] May Be Immunosuppressive but Autologous [[MSC]] Are Dysfunctional in Lupus Patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31799252


|keywords=* dysfunction
* immunoregulatory
* mesenchymal stem cells
* senescence
* systemic lupus erythematosus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874144
}}
{{medline-entry
|title=Effects of high glucose conditions on the expansion and differentiation capabilities of mesenchymal stromal cells derived from rat endosteal niche.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31752674

|mesh-terms=* Adipogenesis
* Animals
* Biomarkers
* Bone Regeneration
* Bone and Bones
* Cell Differentiation
* Cell Proliferation
* Cells, Cultured
* Cellular Senescence
* Diabetes Mellitus, Type 2
* Glucose
* Hyperglycemia
* Male
* Mesenchymal Stem Cells
* Osteogenesis
* Rats, Wistar
|keywords=* Bone repair
* Cellular senescence
* Differentiation
* Hyperglycaemia
* Mesenchymal stromal cells; Endosteum
* Type II diabetes
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873668
}}
{{medline-entry
|title=Autophagy inhibits the mesenchymal stem cell aging induced by D-galactose through ROS/JNK/p38 signalling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31675454


|keywords=* ROS/JNK/p38 signalling
* autophagy
* mesenchymal stem cells
* senescence
|full-text-url=https://sci-hub.do/10.1111/1440-1681.13207
}}
{{medline-entry
|title=Enhancing survival, engraftment, and osteogenic potential of mesenchymal stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31692976


|keywords=* Anoikis
* Bioactive scaffolds
* Bone regeneration
* Engraftment
* Homing
* Hypoxia
* Mesenchymal stem cells
* Osteogenesis
* Preconditioning
* Senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828596
}}
{{medline-entry
|title=Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31644429

|mesh-terms=* Animals
* Cell Proliferation
* Cells, Cultured
* Cellular Senescence
* Chondrocytes
* Coculture Techniques
* Collagenases
* Etoposide
* Gene Expression Regulation
* Humans
* Inflammation
* Luciferases
* Male
* Mesenchymal Stem Cells
* Mice
* Mice, Inbred Strains
* Mice, Transgenic
* Osteoarthritis
* Paracrine Communication
|keywords=* mesenchymal stem cell
* osteoarthritis
* senescence
* tissue homeostasis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834426
}}
{{medline-entry
|title=Embryonic stem cell-derived extracellular vesicles enhance the therapeutic effect of mesenchymal stem cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31660081

|mesh-terms=* Animals
* Cell- and Tissue-Based Therapy
* Cellular Senescence
* Disease Models, Animal
* Embryonic Stem Cells
* Extracellular Vesicles
* Humans
* Insulin-Like Growth Factor I
* Mesenchymal Stem Cell Transplantation
* Mesenchymal Stem Cells
* Mice
* Mice, Inbred BALB C
* Phosphatidylinositol 3-Kinases
* Wounds and Injuries
|keywords=* Cellular senescence
* Embryonic stem cells
* Extracellular vesicles
* IGF1/PI3K/AKT pathway
* Mesenchymal stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815953
}}
{{medline-entry
|title=Survival of aging CD264  and CD264  populations of human bone marrow mesenchymal stem cells is independent of colony-forming efficiency.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31612990


|keywords=* aging
* decoy TRAIL receptor 2 (CD264)
* mesenchymal stem cells
* survival
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6906265
}}
{{medline-entry
|title=Differential effects of extracellular vesicles from aging and young mesenchymal stem cells in acute lung injury.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31575829

|mesh-terms=* Acute Lung Injury
* Age Factors
* Animals
* Disease Models, Animal
* Extracellular Vesicles
* Mesenchymal Stem Cell Transplantation
* Mesenchymal Stem Cells
* Mice
* Treatment Outcome
|keywords=* ARDS
* acute lung injury
* aging
* extracellular vesicles
* mesenchymal stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781978
}}
{{medline-entry
|title=Connexin43 is Dispensable for Early Stage Human Mesenchymal Stem Cell Adipogenic Differentiation But is Protective against Cell Senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31514306

|mesh-terms=* Adipogenesis
* Cell Differentiation
* Cellular Senescence
* Connexin 43
* Gene Expression Regulation
* Humans
* Mesenchymal Stem Cells
* Time Factors
|keywords=* CRISPR-Cas9
* adipogenesis
* connexin43
* gap junctional intercellular communication
* mesenchymal stem cells
* oculodentodigital dysplasia
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770901
}}
{{medline-entry
|title=Maintained Properties of Aged Dental Pulp Stem Cells for Superior Periodontal Tissue Regeneration.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31440385


|keywords=* inflammation
* mesenchymal stem cells
* periodontitis
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675537
}}