Редактирование: Whole brain emulation (раздел)

=== Unknown Ion Channels ===

* Similar to receptors, there are likely unknown ion channels that affect neuron dynamics.  

*  
The Ligand Gated Ion Channel Database currently contains 554 entries with 71 designated as 
channel subunits from Homo sapiens (EMBL‐EBI, 2008; Donizelli, Djite et al., 2006). Voltage 
gated ion channels form a superfamily with at least 143 genes (Yu, Yarov‐Yarovoy et al., 
2005). This diversity is increased by multimerization (combinations of different subunits), 
modifier subunits that do not form channels on their own but affect the function of channels 
they are incorporated into, accessory proteins as well as alternate mRNA splicing and post‐
translational modification (Gutman, Chandy et al., 2005). This would enable at least an order 
of magnitude more variants.  

* Ion channel diversity increases the diversity of possible neuron electrophysiology, but not 
necessarily in a linear manner. See the discussion of inferring electrophysiology from gene 
transcripts in the interpretation chapter.