Редактирование: Публикации о генах и старении (titles) (раздел)

==APP==

{{medline-entry
|title=Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32917871

|mesh-terms=* Aging
* Alzheimer Disease
* Amyloid beta-Peptides
* Animals
* Behavior, Animal
* Cognitive Dysfunction
* Cytokines
* Dipeptides
* Disease Models, Animal
* Encephalitis
* Female
* Humans
* Inflammation
* Male
* Memory Disorders
* Mice
* Mice, Inbred C57BL
* Mice, Transgenic
* Serpins
* Spatial Memory
* Viral Proteins
* para-Aminobenzoates

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486940
}}
{{medline-entry
|title=Regorafenib Regulates AD Pathology, Neuroinflammation, and Dendritic Spinogenesis in Cells and a Mouse Model of AD.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32660121


|keywords=* aging
* amyloid beta
* dendritic spine
* neuroinflammation
* regorafenib
* tau
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408082
}}
{{medline-entry
|title=An agnostic reevaluation of the amyloid cascade hypothesis of Alzheimer's disease pathogenesis: The role of [[APP]] homeostasis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32588983


|keywords=* aging
* amyloid hypothesis
* amyloid precursor protein homeostasis
* late onset Alzheimer's disease
* young onset Alzheimer's disease
|full-text-url=https://sci-hub.do/10.1002/alz.12124
}}
{{medline-entry
|title=Transcriptomic profiling of microglia and astrocytes throughout aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32238175


|keywords=* Aging
* Alzheimer’s disease (AD)
* Astrocyte
* Microglia
* RNA-seq
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115095
}}
{{medline-entry
|title=Platelets in Amyloidogenic Mice Are Activated and Invade the Brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32194368


|keywords=* Alzheimer’s disease
* aging
* astrocytes
* platelets
* vascular pathology
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063083
}}
{{medline-entry
|title=CHIP modulates [[APP]]-induced autophagy-dependent pathological symptoms in Drosophila.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31777182

|mesh-terms=* Alzheimer Disease
* Amyloid beta-Protein Precursor
* Animals
* Aspartic Acid Endopeptidases
* Autophagy
* Brain
* Cognitive Dysfunction
* Disease Models, Animal
* Dopaminergic Neurons
* Down-Regulation
* Drosophila
* Drosophila Proteins
* Eye
* Learning Disabilities
* Locomotion
* Longevity
* Nuclear Proteins
* Presenilins
* RNA Interference
* Wings, Animal
|keywords=* 
CHIP

* APP
* Alzheimer’s disease
* Aβ
* autophagy
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996943
}}
{{medline-entry
|title=Studies on [[APP]] metabolism related to age-associated mitochondrial dysfunction in [[APP]]/PS1 transgenic mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31744937

|mesh-terms=* Adenosine Triphosphate
* Aging
* Alzheimer Disease
* Amyloid beta-Protein Precursor
* Animals
* Blood Platelets
* Disease Models, Animal
* Hippocampus
* Mice
* Mice, Inbred C57BL
* Mice, Transgenic
* Mitochondria
* Presenilin-1
|keywords=* APP/PS1 mice
* Amyloid-beta
* adenosine 5’-triphosphate
* mitochondria dysfunction
* platelets
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914425
}}
{{medline-entry
|title=Intermittent Hypoxia-Hyperoxia Training Improves Cognitive Function and Decreases Circulating Biomarkers of Alzheimer's Disease in Patients with Mild Cognitive Impairment: A Pilot Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31671598

|mesh-terms=* Aged
* Alzheimer Disease
* Biomarkers
* Case-Control Studies
* Cognition
* Cognitive Dysfunction
* Female
* Humans
* Hyperoxia
* Hypoxia
* Male
* Middle Aged
* Pilot Projects
* Respiratory Therapy
* Treatment Outcome
|keywords=* Alzheimer’s disease
* adaptation
* aging
* amyloid beta
* biomarker
* cognitive function
* hyperoxia
* intermittent hypoxia
* platelets
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862463
}}
{{medline-entry
|title=The Implication of Androgens in the Presence of Protein Kinase C to Repair Alzheimer’s Disease-Induced Cognitive Dysfunction
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31677609

|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Alzheimer Disease
* Amyloid Precursor Protein Secretases
* Amyloid beta-Peptides
* Androgens
* Aspartic Acid Endopeptidases
* Cognition
* Cognitive Dysfunction
* Cyclic AMP Response Element-Binding Protein
* Female
* Hippocampus
* Humans
* Learning
* MAP Kinase Signaling System
* Male
* Middle Aged
* Neoplasm Proteins
* Phosphorylation
* Protein Kinase C
* Receptors for Activated C Kinase
* tau Proteins
|keywords=* Androgens
* Cognition
* Hippocampus
* Protein kinase C
* Spatial memory
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984714
}}
{{medline-entry
|title=Modulation of Neural and Muscular Adaptation Processes During Resistance Training by Fish Protein Ingestions in Older Adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31596471


|keywords=* Aging
* Alaska pollack protein
* Motor unit identification
* Multichannel surface electromyography
* Nutritional supplementation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164534
}}
{{medline-entry
|title=Antipsychotic Polypharmacy in Older Adult Asian Patients With Schizophrenia: Research on Asian Psychotropic Prescription Pattern.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31480982

|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Antipsychotic Agents
* Asian Continental Ancestry Group
* Female
* Humans
* Male
* Middle Aged
* Polypharmacy
* Schizophrenia
|keywords=* Asian
* antipsychotic polypharmacy
* older adult patients
* schizophrenia
|full-text-url=https://sci-hub.do/10.1177/0891988719862636
}}
{{medline-entry
|title=A pleiotropic role for exosomes loaded with the amyloid β precursor protein carboxyl-terminal fragments in the brain of Down syndrome patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31479861

|mesh-terms=* Amyloid beta-Protein Precursor
* Brain
* Down Syndrome
* Exosomes
* Humans
|keywords=* APP
* APP-CTFs
* Aging
* Brain
* Down syndrome
* Exosomes
* Extracellular vesicles
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6960325
}}