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==APOE== {{medline-entry |title=Polygenic risk score of longevity predicts longer survival across an age-continuum. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33216869 |keywords=* centenarians * cognitive health * genetics * healthy aging * longevity |full-text-url=https://sci-hub.do/10.1093/gerona/glaa289 }} {{medline-entry |title=Association Between [[APOE]] Alleles and Change of Neuropsychological Tests in the Long Life Family Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33216038 |keywords=* APOE * cognition * longevity * longitudinal studies |full-text-url=https://sci-hub.do/10.3233/JAD-201113 }} {{medline-entry |title=The [[APOE]] gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33215813 |keywords=* Alzheimer's disease * aging * air pollution * apolipoprotein E * chromosome 19q13 |full-text-url=https://sci-hub.do/10.1002/alz.12230 }} {{medline-entry |title=Homozygosity in the [i][[APOE]][/i] 3 Polymorphism Is Associated With Less Depression and Higher Serum Low-Density Lipoprotein in Chinese Elderly Schizophrenics. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33178131 |keywords=* APOE E3 * Chinese * aging * depressive symptom * schizophrenia |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593819 }} {{medline-entry |title=Effect of apolipoprotein E polymorphism on cognition and brain in the Cambridge Centre for Ageing and Neuroscience cohort. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33088920 |keywords=* Cognition * ageing * apolipoprotein E * brain * lifespan |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545750 }} {{medline-entry |title=Cardiovascular risk factors and [[APOE]]-ε4 status affect memory functioning in aging via changes to temporal stem diffusion. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33070365 |keywords=* APOE * BMI * RRID:SCR_001398 * RRID:SCR_002403 * RRID:SCR_002823 * RRID:SCR_002865 * RRID:SCR_007037 * aging * diffusion tensor imaging * hypertension * memory * path modeling |full-text-url=https://sci-hub.do/10.1002/jnr.24734 }} {{medline-entry |title=[[APOE]] [i]ε[/i]4 and resting-state functional connectivity in racially/ethnically diverse older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32999914 |keywords=* APOE ε4 differences * brain aging * dementia * neuroimaging * racial/ethnic differences * resting‐state functional connectivity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508460 }} {{medline-entry |title=Predictors of Olfactory Decline in Aging: A Longitudinal Population-Based Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32886741 |keywords=* Cognitive aging * Epidemiology * Olfactory * Olfactory impairment |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662159 }} {{medline-entry |title=When Culture Influences Genes: Positive Age Beliefs Amplify the Cognitive-Aging Benefit of [[APOE]] ε2. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32835364 |keywords=* APOE * Age beliefs * Cognition * Gene * Health and Retirement Study * Self-perceptions of aging |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489069 }} {{medline-entry |title=Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32817639 |mesh-terms=* Adult * Aged * Aged, 80 and over * Aging * Alzheimer Disease * Apolipoprotein E4 * Biomarkers * Case-Control Studies * Cohort Studies * Female * Genotype * Humans * Male * Middle Aged |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446786 }} {{medline-entry |title=Estimating the potential for dementia prevention through modifiable risk factors elimination in the real-world setting: a population-based study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32767997 |keywords=* Aging * Alzheimer’s disease * Dementia * Dementia prevention * Modifiable risk factors * Population attributable fraction * Public health |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414752 }} {{medline-entry |title=Machine learning-based estimation of cognitive performance using regional brain MRI markers: the Northern Manhattan Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32740887 |keywords=* Biomarkers * Brain aging * Cognitive aging * Machine learning |full-text-url=https://sci-hub.do/10.1007/s11682-020-00325-3 }} {{medline-entry |title=Effects of an [[APOE]] Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32694990 |keywords=* APOE promoter * aging * brain connectome * fronto-parietal network * working memory |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338603 }} {{medline-entry |title=The relationship of parental longevity with the aging brain-results from UK Biobank. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32671621 |keywords=* Aging * Brain structure * DTI * MRI * Neuroimaging * Parental longevity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525531 }} {{medline-entry |title=Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32610143 |keywords=* Alzheimer’s disease * aging * microglia * neurodegenerative diseases * neuroinflammation * transcriptomics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422733 }} {{medline-entry |title=Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer's Disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32474467 |keywords=* APOEɛ4 * Aging * Alzheimer’s disease * gender * lipid species |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369125 }} {{medline-entry |title=Effects of sex, age, and apolipoprotein E genotype on hippocampal parenchymal fraction in cognitively normal older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32416384 |mesh-terms=* Age Factors * Aged * Aged, 80 and over * Apolipoproteins E * Biomarkers * Cognition * Databases, Factual * Female * Genotype * Hippocampus * Humans * Linear Models * Male * Middle Aged * Neuroimaging * Organ Size * Parenchymal Tissue * Reference Values * Sex Factors |keywords=* Alzheimer’s disease * Apolipoprotein E ϵ4 * Atrophy * Brain * Healthy aging * Hippocampal parenchymal fraction * Hippocampal volumetric integrity * Hippocampus * MRI * Mild cognitive impairment * Neurodegeneration * Sex |full-text-url=https://sci-hub.do/10.1016/j.pscychresns.2020.111107 }} {{medline-entry |title=Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32380778 |keywords=* Cilento Region * cognitive health * lifestyle * longevity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279440 }} {{medline-entry |title=Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32342099 |keywords=* Aging * Alzheimer’s disease * Apolipoprotein E * Cognition * Cognitive frailty * Frailty * Male |full-text-url=https://sci-hub.do/10.1093/gerona/glaa105 }} {{medline-entry |title=CSF amyloid is a consistent predictor of white matter hyperintensities across the disease course from aging to Alzheimer's disease. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32305782 |mesh-terms=* Aged * Aged, 80 and over * Aging * Alzheimer Disease * Amyloid beta-Peptides * Biomarkers * Cerebrovascular Disorders * Cognitive Dysfunction * Female * Humans * Magnetic Resonance Imaging * Male * Peptide Fragments * White Matter * tau Proteins |keywords=* Alzheimer's disease * Amyloid * Cerebrospinal fluid * Tau * Vascular disease * White matter hyperintensities |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.03.008 }} {{medline-entry |title=Association of Cardiovascular Risk Factors with Cerebral Perfusion in Whites and African Americans. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32310160 |keywords=* Aging * Alzheimer’s disease * blood pressure * cerebrovascular circulation * neuroimaging * obesity |full-text-url=https://sci-hub.do/10.3233/JAD-190360 }} {{medline-entry |title=Alzheimer's Risk Factors Age, [[APOE]] Genotype, and Sex Drive Distinct Molecular Pathways. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32199103 |mesh-terms=* Adaptor Proteins, Signal Transducing * Age Factors * Aging * Alzheimer Disease * Animals * Apolipoprotein E2 * Apolipoprotein E3 * Apolipoprotein E4 * Apolipoproteins E * Brain * Female * Gene Expression * Gene Expression Profiling * Gene Regulatory Networks * Genotype * Humans * Male * Membrane Glycoproteins * Membrane Proteins * Metabolome * Mice * Mice, Transgenic * Protective Factors * Receptors, Immunologic * Risk Factors * Serpins * Sex Factors * Unfolded Protein Response |keywords=* APOE * Alzheimer’s disease * Serpina3 * age * extracellular vesicles * inflammation * lipid metabolism * metabolomics * sex * transcriptomics |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388065 }} {{medline-entry |title=Less agreeable, better preserved? A PET amyloid and MRI study in a community-based cohort. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32169357 |mesh-terms=* Aged * Aged, 80 and over * Amyloidogenic Proteins * Apolipoproteins E * Brain * Cognition * Cohort Studies * Female * Follow-Up Studies * Humans * Magnetic Resonance Imaging * Male * Neuroimaging * Organ Size * Personality * Positron-Emission Tomography |keywords=* Amyloid load * Cognitive aging * Cohort studies * Personality * Structural MRI |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.02.004 }} {{medline-entry |title=Physical Activity as Moderator of the Association Between [[APOE]] and Cognitive Decline in Older Adults: Results from Three Longitudinal Cohort Studies. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32110803 |keywords=* Gene–environment interaction * InCHIANTI * Longitudinal Aging Study Amsterdam * Rotterdam Study |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518558 }} {{medline-entry |title=Longitudinal Maintenance of Cognitive Health in Centenarians in the 100-plus Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32101309 |mesh-terms=* Aged, 80 and over * Aging * Apolipoprotein E4 * Cognition * Female * Humans * Longitudinal Studies * Male * Mental Status and Dementia Tests * Prospective Studies |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137688 }} {{medline-entry |title=Interaction of [[APOE]], cerebral blood flow, and cortical thickness in the entorhinal cortex predicts memory decline. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32048144 |keywords=* APOE ε4 * Aging * Cerebral blood flow * Cognitive decline * Cortical thickness |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165062 }} {{medline-entry |title=Determinants of mesial temporal lobe volume loss in older individuals with preserved cognition: a longitudinal PET amyloid study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32057528 |mesh-terms=* Aged * Aged, 80 and over * Aging * Alleles * Amyloidogenic Proteins * Apolipoprotein E4 * Cognitive Reserve * Female * Follow-Up Studies * Genotype * Humans * Longitudinal Studies * Male * Neuropsychological Tests * Organ Size * Positron-Emission Tomography * Sex Factors * Temporal Lobe |keywords=* APOE * Amyloid load * Cognitive changes * Mesial temporal lobe * Normal aging * Structural MRI |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2019.12.002 }} {{medline-entry |title=Long-term exposure to ambient air pollution, [[APOE]]-ε4 status, and cognitive decline in a cohort of older adults in northern Manhattan. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31926436 |mesh-terms=* Aged * Air Pollutants * Air Pollution * Apolipoprotein E4 * Apolipoproteins E * Cognitive Dysfunction * Female * Genotype * Humans * Male * Prospective Studies * Washington |keywords=* APOE-ε4 allele * Aging * Air pollution * Cognitive decline * Cognitive risk factors * Epidemiology |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024003 }} {{medline-entry |title=Evidence in support of chromosomal sex influencing plasma based metabolome vs [[APOE]] genotype influencing brain metabolome profile in humanized [[APOE]] male and female mice. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31917799 |mesh-terms=* Age of Onset * Aging * Alzheimer Disease * Amyloid beta-Peptides * Animals * Apolipoprotein E4 * Apolipoproteins E * Brain * Disease Models, Animal * Female * Genotype * Humans * Magnetic Resonance Imaging * Male * Metabolome * Mice * Mice, Transgenic * Sex Characteristics * Sex Chromosomes |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952084 }} {{medline-entry |title=[[APOE]] region molecular signatures of Alzheimer's disease across races/ethnicities. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31813627 |mesh-terms=* Alleles * Alzheimer Disease * Apolipoproteins E * Continental Population Groups * Haplotypes * Heterozygote * Homozygote * Humans * Linkage Disequilibrium * Polymorphism, Single Nucleotide * Risk Factors |keywords=* APOE polymorphism * Aging * Alzheimer's disease * Health span * Life span * Neurodegenerative disorders |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064423 }} {{medline-entry |title=Varying Effects of [[APOE]] Alleles on Extreme Longevity in European Ethnicities. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31724059 |mesh-terms=* Aged, 80 and over * Alleles * Apolipoproteins E * Ethnic Groups * Europe * European Continental Ancestry Group * Female * Humans * Longevity * Male |keywords=* APOE * Bioinformatics * Human genetics * Longevity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330482 }} {{medline-entry |title=Prospective Evaluation of Cognitive Health and Related Factors in Elderly at Risk for Developing Alzheimer's Dementia: A Longitudinal Cohort Study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31686098 |mesh-terms=* Aged * Aged, 80 and over * Alzheimer Disease * Anxiety * Apolipoprotein E4 * Cognition * Cognitive Dysfunction * Cohort Studies * Depression * Efficiency * Female * Healthy Volunteers * Humans * Longitudinal Studies * Male * Mental Status and Dementia Tests * Middle Aged * Neuropsychological Tests * Prospective Studies * Risk Factors * Sleep * United Kingdom * Work |keywords=* Alzheimer Disease * CHARIOT * aging registry * cognitive health * pre-clinical |full-text-url=https://sci-hub.do/10.14283/jpad.2019.31 }} {{medline-entry |title=Association of Cardiovascular and Alzheimer's Disease Risk Factors with Intracranial Arterial Blood Flow in Whites and African Americans. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31658057 |mesh-terms=* African Americans * Aged * Alzheimer Disease * Biomarkers * Blood Flow Velocity * Cardiovascular Diseases * Cerebrovascular Circulation * European Continental Ancestry Group * Female * Humans * Male * Middle Aged * Risk Factors |keywords=* African Americans * Alzheimer’s disease * Apolipoprotein E4 * aging * cerebrovascular circulation * glucose * metabolic syndrome * neuroimaging * risk factors |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081660 }} {{medline-entry |title=Is Ongoing Anticholinergic Burden Associated With Greater Cognitive Decline and Dementia Severity in Mild to Moderate Alzheimer's Disease? |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31613323 |keywords=* Alzheimers * Cognitive aging * Drug related * Medication |full-text-url=https://sci-hub.do/10.1093/gerona/glz244 }} {{medline-entry |title=Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31630996 |mesh-terms=* Age Factors * Aged * Aged, 80 and over * Alzheimer Disease * Amyloid * Biomarkers * Cohort Studies * Europe * Female * Humans * Inflammation * Male * Middle Aged * Parkinson Disease * Sex Factors * tau Proteins |keywords=* Aging * Alzheimer's disease * Amyloid * Biomarker * Cerebrospinal fluid * Inflammation * Mild cognitive impairment * Multicenter * Parkinson's disease * Tau |full-text-url=https://sci-hub.do/10.1016/j.jalz.2019.07.018 }} {{medline-entry |title=Prospective Memory: Age related change is influenced by [[APOE]] genotype. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31578124 |keywords=* APOE * Alzheimer’s disease * aging * mid-adulthood * prospective memory |full-text-url=https://sci-hub.do/10.1080/13825585.2019.1671305 }} {{medline-entry |title=Education Moderates the Relation Between [[APOE]] ɛ4 and Memory in Nondemented Non-Hispanic Black Older Adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31594222 |mesh-terms=* Adult * African Americans * Aged * Aged, 80 and over * Aging * Alzheimer Disease * Apolipoprotein E4 * Cognitive Reserve * Educational Status * Executive Function * Female * Humans * Male * Memory * Memory, Episodic * Memory, Short-Term * Middle Aged * Neuropsychological Tests * Sex Characteristics |keywords=* APOE * African American * Alzheimer’s disease * cognitive reserve * educational attainment * episodic memory * genetic risk * neuropsychological evaluation |full-text-url=https://sci-hub.do/10.3233/JAD-190415 }} {{medline-entry |title=Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31561966 |mesh-terms=* Age Factors * Aged * Alleles * Apolipoprotein E4 * Cognition Disorders * European Continental Ancestry Group * Executive Function * Female * Humans * Longitudinal Studies * Male * Memory * Neuropsychological Tests * Sex Factors |keywords=* Aging * Alzheimer's disease * Apolipoprotein E ε4 * Cognitive decline * Sex |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561018 }} {{medline-entry |title=Interactive effect of age and [[APOE]]-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31520917 |mesh-terms=* Age Factors * Aged * Aging * Apolipoprotein E4 * Female * Humans * Magnetic Resonance Imaging * Male * Middle Aged * Myelin Sheath * White Matter |keywords=* Aging * Alzheimer * Apolipoprotein E * Cognitively normal subjects * Myelination * T1w/T2w ratio * White matter integrity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742967 }} {{medline-entry |title=[[APOE]] modifies the interaction of entorhinal cerebral blood flow and cortical thickness on memory function in cognitively normal older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31493534 |mesh-terms=* Aged * Aged, 80 and over * Apolipoproteins E * Cerebral Cortex * Cerebrovascular Circulation * Entorhinal Cortex * Female * Genotype * Humans * Linear Models * Male * Memory * Middle Aged |keywords=* APOE ε4 * Aging * Alzheimer’s disease * Cerebral blood flow * Cognitive decline * Cortical thickness |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819270 }} {{medline-entry |title=When time's arrow doesn't bend: [[APOE]]-ε4 influences episodic memory before old age. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31473197 |mesh-terms=* Adult * Alleles * Alzheimer Disease * Apolipoprotein E4 * Cognition * Cognitive Aging * Female * Genotype * Humans * Linear Models * Male * Memory * Memory, Episodic * Middle Aged * Young Adult |keywords=* Alzheimer's diseas * Apolipoprotein E * Cognition * Episodic memory * Semantic memory |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817416 }} {{medline-entry |title=Cognitive-Motor Integration Performance Is Affected by Sex, [[APOE]] Status, and Family History of Dementia. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31424400 |mesh-terms=* Aged * Apolipoproteins E * Cognition * Cognitive Dysfunction * Cross-Sectional Studies * Dementia * Female * Humans * Male * Medical History Taking * Middle Aged * Photic Stimulation * Psychomotor Performance * Sex Characteristics * Surveys and Questionnaires |keywords=* Aging * alzheimer’s disease * apolipoprotein E4 * dementia risk * geriatric assessment * motor skills * movement * visuomotor integration |full-text-url=https://sci-hub.do/10.3233/JAD-190403 }} {{medline-entry |title=Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31437719 |mesh-terms=* Aged * Aged, 80 and over * Aging * Amyloid beta-Peptides * Atrophy * Brain * Cognition * Cognitive Dysfunction * Databases, Factual * Female * Humans * Longitudinal Studies * Male * Middle Aged |keywords=* Aging * Alzheimer's disease * Amyloid-β * Brain atrophy |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198229 }} {{medline-entry |title=Cognitive function and neuropathological outcomes: a forward-looking approach. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31435771 |mesh-terms=* Aged * Aged, 80 and over * Aging * Alzheimer Disease * Cognitive Dysfunction * Female * Humans * Male * Middle Aged |keywords=* Alzheimer’s disease * Cognition * Multi-state model * Neuropathology |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851487 }} {{medline-entry |title=[[APOE]] gene-dependent BOLD responses to a breath-hold across the adult lifespan. |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31408838 |mesh-terms=* Adult * Aged * Aging * Apolipoprotein E3 * Apolipoprotein E4 * Apolipoproteins E * Breath Holding * Cerebrovascular Circulation * Cross-Over Studies * Double-Blind Method * Female * Genotype * Hemodynamics * Humans * Longevity * Magnetic Resonance Imaging * Male * Middle Aged * Nitrates |keywords=* Ageing * Alzheimer's disease * Apolipoprotein E * BOLD fMRI * Breath-hold * Cerebrovascular reactivity |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699560 }}
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