Редактирование: Whole brain emulation (раздел)

==== Data Interpolation ====

[[File:artifact.jpg|thumb|left|Artifacts in electron micrographs cause loss of data. The missing neurites have to be interpolated from information of the surrounding tissues. (From the [[Nervous System State Vectors & Scan Data#Denk-Horstmann|Denk-Horstmann]] dataset, layer 49).]]

Scanning a volume as large as the brain is likely to produce large volumes where data is lost (For example, the KESM suffers data up to 5 µm in width between different columns<ref>Kwon J, Mayerich D, Choe Y, McCormick BH. "Automated lateral sectioning for knife‐edge scanning microscopy". In ''IEEE international symposium on biomedical imaging: From nano to macro'', 2008.</ref>. In a sufficiently small case, surrounding data may be used to probabilistically interpolate the brain structure in the lost areas. In a large enough volume, however, interpolation is not sufficient, and one must generate a brain structure to fill the lost volume, using knowledge of the surrounding structure (For example, all neurons in the cerebral cortex are pyramidal, so if there is a lost volume in the cortex, stellate cells cannot be inserted.

This is a high priority issue, since lost or poorly interpolated data may case mis tracing and an inexact emulation.