Редактирование: Aging genes 50-59 (раздел)

==TP53==

* {{medline-title
|title=The DNA methylation of [[FOXO3]] and [[TP53]] as a blood biomarker of late-onset asthma.
|date=09.12.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33298101
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726856
}}
* {{medline-title
|title=The effect of aging on the biological and immunological characteristics of periodontal ligament stem cells.
|date=29.07.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32727592
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392710
}}
* {{medline-title
|title=Ovarian aging increases small extracellular vesicle [[CD81]]  release in human follicular fluid and influences miRNA profiles.
|date=17.06.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32554857
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343446
}}
* {{medline-title
|title=p53 inhibits the osteogenic differentiation but does not induce senescence in human dental follicle cells.
|date=07-08.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32473528
|full-text-url=https://sci-hub.do/10.1016/j.diff.2020.05.003
}}
* {{medline-title
|title=p53 and p53-related mediators PAI-1 and IGFBP-3 are downregulated in peripheral blood mononuclear cells of HIV-patients exposed to non-nucleoside reverse transcriptase inhibitors.
|date=06.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32272174
|full-text-url=https://sci-hub.do/10.1016/j.antiviral.2020.104784
}}
* {{medline-title
|title=Mutational spectrum and dynamics of clonal hematopoiesis in anemia of older individuals.
|date=02.04.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32243522
|full-text-url=https://sci-hub.do/10.1182/blood.2019004362
}}
* {{medline-title
|title=[[TP53]]/miR-34a-associated signaling targets [i]SERPINE1[/i] expression in human pancreatic cancer.
|date=27.01.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31986125
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041729
}}
* {{medline-title
|title=Expression of p16 in nodular fasciitis: an implication for self-limited and inflammatory nature of the lesion.
|date=2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31933915
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945175
}}
* {{medline-title
|title=Candesartan Neuroprotection in Rat Primary Neurons Negatively Correlates with Aging and Senescence: a Transcriptomic Analysis.
|date=03.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31811565
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062590
}}
* {{medline-title
|title=Chlorella vulgaris modulates the expression of senescence-associated genes in replicative senescence of human diploid fibroblasts.
|date=01.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31642042
|full-text-url=https://sci-hub.do/10.1007/s11033-019-05140-8
}}
* {{medline-title
|title=Biomarkers for vascular ageing in aorta tissues and blood samples.
|date=12.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31648011
|full-text-url=https://sci-hub.do/10.1016/j.exger.2019.110741
}}
* {{medline-title
|title=Ultra-Sensitive [[TP53]] Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan.
|date=02.07.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31269435
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639023
}}
* {{medline-title
|title=Collaboration of [[MYC]] and [[RUNX2]] in lymphoma simulates T-cell receptor signaling and attenuates p53 pathway activity.
|date=10.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31257681
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772115
}}
* {{medline-title
|title=mTOR Signaling Pathway Regulates Sperm Quality in Older Men.
|date=21.06.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31234465
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627782
}}
* {{medline-title
|title=[i][[TP53]][/i] Tumor-suppressor Gene Plays a Key Role in [[IGF1]] Signaling Pathway Related to the Aging of Human Melanocytes.
|date=05.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31092438
|full-text-url=https://sci-hub.do/10.21873/anticanres.13363
}}
* {{medline-title
|title=Distinct cellular responses to replication stress leading to apoptosis or senescence.
|date=05.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30982228
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487726
}}
* {{medline-title
|title=Somatic genome alterations in relation to age in lung adenocarcinoma.
|date=15.10.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30859574
|full-text-url=https://sci-hub.do/10.1002/ijc.32265
}}
* {{medline-title
|title=Predictors of disease aggressiveness influence outcome from immunotherapy treatment in renal clear cell carcinoma.
|date=2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30546942
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287778
}}
* {{medline-title
|title=Adipose [[TSHB]] in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence.
|date=2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30448824
|full-text-url=https://sci-hub.do/10.1159/000495170
}}
* {{medline-title
|title=Breast cancer survival predicted by [[TP53]] mutation status differs markedly depending on treatment.
|date=01.10.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30285883
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167800
}}
* {{medline-title
|title=Defective autophagy in vascular smooth muscle cells enhances cell death and atherosclerosis.
|date=2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30025494
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152523
}}
* {{medline-title
|title=Detection of a novel, primate-specific 'kill switch' tumor suppression mechanism that may fundamentally control cancer risk in humans: an unexpected twist in the basic biology of [[TP53]].
|date=11.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29941676
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106910
}}
* {{medline-title
|title=Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo.
|date=08.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29923368
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052487
}}
* {{medline-title
|title=Troponin T3 associates with DNA consensus sequence that overlaps with p53 binding motifs.
|date=15.07.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29596868
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994179
}}
* {{medline-title
|title=The genetic component of human longevity: New insights from the analysis of pathway-based SNP-SNP interactions.
|date=06.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29577582
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946073
}}
* {{medline-title
|title=Identification of human age-associated gene co-expressions in functional modules using liquid association.
|date=02.01.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29416677
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787419
}}
* {{medline-title
|title=Genetic interrogation of replicative senescence uncovers a dual role for [[USP28]] in coordinating the p53 and [[GATA4]] branches of the senescence program.
|date=01.10.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29089421
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710139
}}
* {{medline-title
|title=A lowered 26S proteasome activity correlates with mantle lymphoma cell lines resistance to genotoxic stress.
|date=10.08.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28797244
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553741
}}
* {{medline-title
|title=Molecular evolutionary patterns of NAD /Sirtuin aging signaling pathway across taxa.
|date=2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28767699
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540417
}}
* {{medline-title
|title=A Multigene Test Could Cost-Effectively Help Extend Life Expectancy for Women at Risk of Hereditary Breast Cancer.
|date=04.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28407996
|full-text-url=https://sci-hub.do/10.1016/j.jval.2017.01.006
}}
* {{medline-title
|title=Comprehensive Analysis of Interaction Networks of Telomerase Reverse Transcriptase with Multiple Bioinformatic Approaches: Deep Mining the Potential Functions of Telomere and Telomerase.
|date=08.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28281877
|full-text-url=https://sci-hub.do/10.1089/rej.2016.1909
}}
* {{medline-title
|title=Establishment and application of a novel patient-derived KIAA1549:[[BRAF]]-driven pediatric pilocytic astrocytoma model for preclinical drug testing.
|date=14.02.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28002790
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355278
}}
* {{medline-title
|title=Roles of [[TP53]] in determining therapeutic sensitivity, growth, cellular senescence, invasion and metastasis.
|date=01.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27776972
|full-text-url=https://sci-hub.do/10.1016/j.jbior.2016.10.001
}}
* {{medline-title
|title=Phosphorylation of [[MITF]] by AKT affects its downstream targets and causes [[TP53]]-dependent cell senescence.
|date=11.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27702651
|full-text-url=https://sci-hub.do/10.1016/j.biocel.2016.09.029
}}
* {{medline-title
|title=Mutational load and mutational patterns in relation to age in head and neck cancer.
|date=25.10.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27596625
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342469
}}
* {{medline-title
|title=GBM-associated mutations and altered protein expression are more common in young patients.
|date=25.10.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27579614
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342491
}}
* {{medline-title
|title=rs78378222 polymorphism in the 3'-untranslated region of [[TP53]] contributes to development of age-associated cataracts by modifying microRNA-125b-induced apoptosis of lens epithelial cells.
|date=09.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27431420
|full-text-url=https://sci-hub.do/10.3892/mmr.2016.5465
}}
* {{medline-title
|title=Evasion of cell senescence in [[SHH]] medulloblastoma.
|date=17.08.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27229128
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4993422
}}
* {{medline-title
|title=Candidate gene resequencing to identify rare, pedigree-specific variants influencing healthy aging phenotypes in the long life family study.
|date=09.04.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27060904
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826550
}}
* {{medline-title
|title=Induction of DNA double-strand breaks and cellular senescence by human respiratory syncytial virus.
|date=18.05.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26809688
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871660
}}
* {{medline-title
|title=Targeting genes in insulin-associated signalling pathway, DNA damage, cell proliferation and cell differentiation pathways by tocotrienol-rich fraction in preventing cellular senescence of human diploid fibroblasts.
|date=11-12.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26794818
|full-text-url=https://sci-hub.do/10.7417/T.2015.1902
}}
* {{medline-title
|title=EBV and not HPV sensitizes tobacco-associated head and neck cancer cell line FaDu to radiotherapy.
|date=2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26635065
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823166
}}
* {{medline-title
|title=Radiation promotes colorectal cancer initiation and progression by inducing senescence-associated inflammatory responses.
|date=30.06.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26477319
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837107
}}
* {{medline-title
|title=The different radiation response and radiation-induced bystander effects in colorectal carcinoma cells differing in p53 status.
|date=08.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26099456
|full-text-url=https://sci-hub.do/10.1016/j.mrfmmm.2015.06.003
}}
* {{medline-title
|title=Epigenetic Aging Signatures Are Coherently Modified in Cancer.
|date=06.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26110659
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482318
}}
* {{medline-title
|title=Solutions to Peto's paradox revealed by mathematical modelling and cross-species cancer gene analysis.
|date=19.07.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26056366
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581027
}}
* {{medline-title
|title=Sensitivity of neoplastic cells to senescence unveiled under standard cell culture conditions.
|date=05.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25964555

}}
* {{medline-title
|title=Human [[TP53]] polymorphism (rs1042522) modelled in mouse does not affect glucose metabolism and body composition.
|date=13.02.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24522546
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923217
}}
* {{medline-title
|title=DNA methylation age of human tissues and cell types.
|date=2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24138928
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015143
}}
* {{medline-title
|title=Regulation of ROS-independent ERK signaling rescues replicative cellular senescence in ex vivo expanded human c-kit-positive cardiac progenitor cells.
|date=25.10.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24094550
|full-text-url=https://sci-hub.do/10.1016/j.ijcard.2013.08.076
}}
* {{medline-title
|title=Prolonged autophagy by [[MTOR]] inhibitor leads radioresistant cancer cells into senescence.
|date=10.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23989658
|full-text-url=https://sci-hub.do/10.4161/auto.25879
}}
* {{medline-title
|title=p53 mutations associated with aging-related rise in cancer incidence rates.
|date=01.08.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23839036
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841325
}}
* {{medline-title
|title=A novel p53 mutant found in iatrogenic urothelial cancers is dysfunctional and can be rescued by a second-site global suppressor mutation.
|date=07.06.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23612969
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675604
}}
* {{medline-title
|title=DNA damage causes [[TP53]]-dependent coupling of self-renewal and senescence pathways in embryonal carcinoma cells.
|date=01.02.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23287532
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3587444
}}