Редактирование: Aging genes 30-59 (раздел)

==PINK1==

* {{medline-title
|title=Spermidine inhibits neurodegeneration and delays aging via the [[PINK1]]-PDR1-dependent mitophagy pathway in [i]C. elegans[/i].
|date=09.09.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32902411
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521492
}}
* {{medline-title
|title=Female mice are resilient to age-related decline of substantia nigra dopamine neuron firing parameters.
|date=11.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32846275
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7606778
}}
* {{medline-title
|title=Attenuation of epigenetic regulator SMARCA4 and ERK-ETS signaling suppresses aging-related dopaminergic degeneration.
|date=09.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32749068
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511865
}}
* {{medline-title
|title=SIRT1 alleviates high-magnitude compression-induced senescence in nucleus pulposus cells via [[PINK1]]-dependent mitophagy.
|date=18.07.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32687063
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485741
}}
* {{medline-title
|title=Synergistic action of propolis with levodopa in the management of Parkinsonism in Drosophila melanogaster.
|date=23.09.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32386191
|full-text-url=https://sci-hub.do/10.1515/jcim-2019-0136
}}
* {{medline-title
|title=Compression-induced senescence of nucleus pulposus cells by promoting mitophagy activation via the [[PINK1]]/PARKIN pathway.
|date=05.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32281308
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214186
}}
* {{medline-title
|title=Doxorubicin-induced normal breast epithelial cellular aging and its related breast cancer growth through mitochondrial autophagy and oxidative stress mitigated by ginsenoside Rh2.
|date=07.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32100342
|full-text-url=https://sci-hub.do/10.1002/ptr.6636
}}
* {{medline-title
|title=Mitochondrial DNA heteroplasmy rises in substantial nigra of aged [[PINK1]] KO mice.
|date=22.01.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31727366
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2019.10.112
}}
* {{medline-title
|title=Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training.
|date=01.10.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31306740
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707857
}}
* {{medline-title
|title=SerThr-PhosphoProteome of Brain from Aged [[PINK1]]-KO A53T-[[SNCA]] Mice Reveals pT1928-[[MAP1B]] and pS3781-[[ANK2]] Deficits, as Hub between Autophagy and Synapse Changes.
|date=04.07.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31277379
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651490
}}
* {{medline-title
|title=Neuronal Mitophagy: Lessons from a Pathway Linked to Parkinson's Disease.
|date=08.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31102068
|full-text-url=https://sci-hub.do/10.1007/s12640-019-00060-8
}}
* {{medline-title
|title=Inhibition of the deubiquitinase [[USP8]] corrects a Drosophila [[PINK1]] model of mitochondria dysfunction.
|date=04.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30988163
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467245
}}
* {{medline-title
|title=Oligonol Alleviates Sarcopenia by Regulation of Signaling Pathways Involved in Protein Turnover and Mitochondrial Quality.
|date=05.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30793867
|full-text-url=https://sci-hub.do/10.1002/mnfr.201801102
}}
* {{medline-title
|title=AMP Kinase Activation is Selectively Disrupted in the Ventral Midbrain of Mice Deficient in Parkin or [[PINK1]] Expression.
|date=03.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30411223
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394446
}}
* {{medline-title
|title=Intensified mitophagy in skeletal muscle with aging is downregulated by [[PGC]]-1alpha overexpression in vivo.
|date=01.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30395971
|full-text-url=https://sci-hub.do/10.1016/j.freeradbiomed.2018.10.456
}}
* {{medline-title
|title=Melatonin protects chronic kidney disease mesenchymal stem cells against senescence via PrP  -dependent enhancement of the mitochondrial function.
|date=01.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30372554
|full-text-url=https://sci-hub.do/10.1111/jpi.12535
}}
* {{medline-title
|title=[[PRKN]]-regulated mitophagy and cellular senescence during COPD pathogenesis.
|date=03.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30290714
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351145
}}
* {{medline-title
|title=Grape skin extract improves muscle function and extends lifespan of a Drosophila model of Parkinson's disease through activation of mitophagy.
|date=11.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30248358
|full-text-url=https://sci-hub.do/10.1016/j.exger.2018.09.014
}}
* {{medline-title
|title=Imaging mitophagy in the fruit fly.
|date=2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29995555
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135567
}}
* {{medline-title
|title=Age- and disease-dependent increase of the mitophagy marker phospho-ubiquitin in normal aging and Lewy body disease.
|date=2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29947276
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372017
}}
* {{medline-title
|title=[[PINK1]] protects against oxidative stress induced senescence of human nucleus pulposus cells via regulating mitophagy.
|date=02.10.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29890141
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2018.06.031
}}
* {{medline-title
|title=Deficiency of parkin and [[PINK1]] impairs age-dependent mitophagy in [i]Drosophila[/i].
|date=29.05.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29809156
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008047
}}
* {{medline-title
|title=[[ATF3]] represses [[PINK1]] gene transcription in lung epithelial cells to control mitochondrial homeostasis.
|date=04.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29363258
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847866
}}
* {{medline-title
|title=In vivo imaging reveals mitophagy independence in the maintenance of axonal mitochondria during normal aging.
|date=10.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28782874
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595681
}}
* {{medline-title
|title=Progression of pathology in [[PINK1]]-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation.
|date=02.08.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28768533
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541666
}}
* {{medline-title
|title=The age-associated loss of ischemic preconditioning in the kidney is accompanied by mitochondrial dysfunction, increased protein acetylation and decreased autophagy.
|date=15.03.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28294175
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353572
}}
* {{medline-title
|title=Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging.
|date=26.02.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28238968
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361683
}}
* {{medline-title
|title=[[PINK1]] signaling in mitochondrial homeostasis and in aging (Review).
|date=01.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27959386
|full-text-url=https://sci-hub.do/10.3892/ijmm.2016.2827
}}
* {{medline-title
|title=Involvement of [[PINK1]]/Parkin-mediated mitophagy in AGE-induced cardiomyocyte aging.
|date=15.01.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27839819
|full-text-url=https://sci-hub.do/10.1016/j.ijcard.2016.11.161
}}
* {{medline-title
|title=Identifying potential PARIS homologs in D. melanogaster.
|date=03.11.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27819722
|full-text-url=https://sci-hub.do/10.4238/gmr15048934
}}
* {{medline-title
|title=Restoring Pharmacologic Preconditioning in the Aging Heart: Role of Mitophagy/Autophagy.
|date=01.04.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27565512
|full-text-url=https://sci-hub.do/10.1093/gerona/glw168
}}
* {{medline-title
|title=HSP27 Alleviates Cardiac Aging in Mice via a Mechanism Involving Antioxidation and Mitophagy Activation.
|date=2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27110324
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821973
}}
* {{medline-title
|title=Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan.
|date=12.04.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27076081
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835580
}}
* {{medline-title
|title=Interfacing mitochondrial biogenesis and elimination to enhance host pathogen defense and longevity.
|date=07-09.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26430570
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588546
}}
* {{medline-title
|title=Deregulation of selective autophagy during aging and pulmonary fibrosis: the role of TGFβ1.
|date=10.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26059457
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568965
}}
* {{medline-title
|title=Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain.
|date=27.05.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26019347
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444551
}}
* {{medline-title
|title=[[PINK1]] deficiency impairs mitochondrial homeostasis and promotes lung fibrosis.
|date=02.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25562319
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319413
}}
* {{medline-title
|title=The degeneration and replacement of dopamine cells in Parkinson's disease: the role of aging.
|date=2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25147507
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124707
}}
* {{medline-title
|title=Defective mitophagy in [[XPA]] via PARP-1 hyperactivation and NAD( )/[[SIRT1]] reduction.
|date=08.05.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24813611
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625837
}}
* {{medline-title
|title=Antiaging properties of a grape-derived antioxidant are regulated by mitochondrial balance of fusion and fission leading to mitophagy triggered by a signaling network of Sirt1-Sirt3-Foxo3-[[PINK1]]-PARKIN.
|date=2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24669285
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942197
}}