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Aging genes 100
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==APOE== * {{medline-title |title=Polygenic risk score of longevity predicts longer survival across an age-continuum. |date=20.11.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33216869 |full-text-url=https://sci-hub.do/10.1093/gerona/glaa289 }} * {{medline-title |title=Association Between [[APOE]] Alleles and Change of Neuropsychological Tests in the Long Life Family Study. |date=17.11.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33216038 |full-text-url=https://sci-hub.do/10.3233/JAD-201113 }} * {{medline-title |title=The [[APOE]] gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans. |date=20.11.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33215813 |full-text-url=https://sci-hub.do/10.1002/alz.12230 }} * {{medline-title |title=Homozygosity in the [i][[APOE]][/i] 3 Polymorphism Is Associated With Less Depression and Higher Serum Low-Density Lipoprotein in Chinese Elderly Schizophrenics. |date=2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33178131 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7593819 }} * {{medline-title |title=Effect of apolipoprotein E polymorphism on cognition and brain in the Cambridge Centre for Ageing and Neuroscience cohort. |date=01-12.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33088920 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545750 }} * {{medline-title |title=Cardiovascular risk factors and [[APOE]]-ε4 status affect memory functioning in aging via changes to temporal stem diffusion. |date=18.10.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33070365 |full-text-url=https://sci-hub.do/10.1002/jnr.24734 }} * {{medline-title |title=[[APOE]] [i]ε[/i]4 and resting-state functional connectivity in racially/ethnically diverse older adults. |date=2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32999914 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508460 }} * {{medline-title |title=Predictors of Olfactory Decline in Aging: A Longitudinal Population-Based Study. |date=13.11.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32886741 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7662159 }} * {{medline-title |title=When Culture Influences Genes: Positive Age Beliefs Amplify the Cognitive-Aging Benefit of [[APOE]] ε2. |date=14.09.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32835364 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489069 }} * {{medline-title |title=Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study. |date=08.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32817639 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446786 }} * {{medline-title |title=Estimating the potential for dementia prevention through modifiable risk factors elimination in the real-world setting: a population-based study. |date=07.08.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32767997 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414752 }} * {{medline-title |title=Machine learning-based estimation of cognitive performance using regional brain MRI markers: the Northern Manhattan Study. |date=01.08.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32740887 |full-text-url=https://sci-hub.do/10.1007/s11682-020-00325-3 }} * {{medline-title |title=Effects of an [[APOE]] Promoter Polymorphism on Fronto-Parietal Functional Connectivity During Nondemented Aging. |date=2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32694990 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338603 }} * {{medline-title |title=The relationship of parental longevity with the aging brain-results from UK Biobank. |date=10.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32671621 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525531 }} * {{medline-title |title=Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation. |date=30.06.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32610143 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422733 }} * {{medline-title |title=Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer's Disease. |date=2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32474467 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369125 }} * {{medline-title |title=Effects of sex, age, and apolipoprotein E genotype on hippocampal parenchymal fraction in cognitively normal older adults. |date=30.07.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32416384 |full-text-url=https://sci-hub.do/10.1016/j.pscychresns.2020.111107 }} * {{medline-title |title=Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). |date=05.05.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32380778 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279440 }} * {{medline-title |title=Apolipoprotein E and Health in Older Men: The Concord Health and Ageing in Men Project. |date=25.09.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32342099 |full-text-url=https://sci-hub.do/10.1093/gerona/glaa105 }} * {{medline-title |title=CSF amyloid is a consistent predictor of white matter hyperintensities across the disease course from aging to Alzheimer's disease. |date=07.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32305782 |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.03.008 }} * {{medline-title |title=Association of Cardiovascular Risk Factors with Cerebral Perfusion in Whites and African Americans. |date=2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32310160 |full-text-url=https://sci-hub.do/10.3233/JAD-190360 }} * {{medline-title |title=Alzheimer's Risk Factors Age, [[APOE]] Genotype, and Sex Drive Distinct Molecular Pathways. |date=03.06.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32199103 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388065 }} * {{medline-title |title=Less agreeable, better preserved? A PET amyloid and MRI study in a community-based cohort. |date=05.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32169357 |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2020.02.004 }} * {{medline-title |title=Physical Activity as Moderator of the Association Between [[APOE]] and Cognitive Decline in Older Adults: Results from Three Longitudinal Cohort Studies. |date=25.09.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32110803 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518558 }} * {{medline-title |title=Longitudinal Maintenance of Cognitive Health in Centenarians in the 100-plus Study. |date=05.02.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32101309 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137688 }} * {{medline-title |title=Interaction of [[APOE]], cerebral blood flow, and cortical thickness in the entorhinal cortex predicts memory decline. |date=04.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32048144 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165062 }} * {{medline-title |title=Determinants of mesial temporal lobe volume loss in older individuals with preserved cognition: a longitudinal PET amyloid study. |date=03.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32057528 |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2019.12.002 }} * {{medline-title |title=Long-term exposure to ambient air pollution, [[APOE]]-ε4 status, and cognitive decline in a cohort of older adults in northern Manhattan. |date=03.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31926436 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024003 }} * {{medline-title |title=Evidence in support of chromosomal sex influencing plasma based metabolome vs [[APOE]] genotype influencing brain metabolome profile in humanized [[APOE]] male and female mice. |date=2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31917799 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952084 }} * {{medline-title |title=[[APOE]] region molecular signatures of Alzheimer's disease across races/ethnicities. |date=03.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31813627 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064423 }} * {{medline-title |title=Varying Effects of [[APOE]] Alleles on Extreme Longevity in European Ethnicities. |date=13.11.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31724059 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330482 }} * {{medline-title |title=Prospective Evaluation of Cognitive Health and Related Factors in Elderly at Risk for Developing Alzheimer's Dementia: A Longitudinal Cohort Study. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31686098 |full-text-url=https://sci-hub.do/10.14283/jpad.2019.31 }} * {{medline-title |title=Association of Cardiovascular and Alzheimer's Disease Risk Factors with Intracranial Arterial Blood Flow in Whites and African Americans. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31658057 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081660 }} * {{medline-title |title=Is Ongoing Anticholinergic Burden Associated With Greater Cognitive Decline and Dementia Severity in Mild to Moderate Alzheimer's Disease? |date=17.04.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31613323 |full-text-url=https://sci-hub.do/10.1093/gerona/glz244 }} * {{medline-title |title=Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study. |date=02.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31630996 |full-text-url=https://sci-hub.do/10.1016/j.jalz.2019.07.018 }} * {{medline-title |title=Prospective Memory: Age related change is influenced by [[APOE]] genotype. |date=09.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31578124 |full-text-url=https://sci-hub.do/10.1080/13825585.2019.1671305 }} * {{medline-title |title=Education Moderates the Relation Between [[APOE]] ɛ4 and Memory in Nondemented Non-Hispanic Black Older Adults. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31594222 |full-text-url=https://sci-hub.do/10.3233/JAD-190415 }} * {{medline-title |title=Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent. |date=12.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31561966 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561018 }} * {{medline-title |title=Interactive effect of age and [[APOE]]-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31520917 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742967 }} * {{medline-title |title=[[APOE]] modifies the interaction of entorhinal cerebral blood flow and cortical thickness on memory function in cognitively normal older adults. |date=15.11.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31493534 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819270 }} * {{medline-title |title=When time's arrow doesn't bend: [[APOE]]-ε4 influences episodic memory before old age. |date=10.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31473197 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6817416 }} * {{medline-title |title=Cognitive-Motor Integration Performance Is Affected by Sex, [[APOE]] Status, and Family History of Dementia. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31424400 |full-text-url=https://sci-hub.do/10.3233/JAD-190403 }} * {{medline-title |title=Associations among amyloid status, age, and longitudinal regional brain atrophy in cognitively unimpaired older adults. |date=10.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31437719 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198229 }} * {{medline-title |title=Cognitive function and neuropathological outcomes: a forward-looking approach. |date=12.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31435771 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851487 }} * {{medline-title |title=[[APOE]] gene-dependent BOLD responses to a breath-hold across the adult lifespan. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31408838 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699560 }} * {{medline-title |title=Medial temporal lobe atrophy and posterior atrophy scales normative values. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31382240 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690662 }} * {{medline-title |title=Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study. |date=09.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31385647 |full-text-url=https://sci-hub.do/10.1002/da.22912 }} * {{medline-title |title=Genetic background, epigenetic factors and dietary interventions which influence human longevity. |date=10.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31309340 |full-text-url=https://sci-hub.do/10.1007/s10522-019-09824-3 }} * {{medline-title |title=Adipose-Derived Stem/Stromal Cells Recapitulate Aging Biomarkers and Show Reduced Stem Cell Plasticity Affecting Their Adipogenic Differentiation Capacity. |date=08.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31298565 |full-text-url=https://sci-hub.do/10.1089/cell.2019.0010 }} * {{medline-title |title=Late life insulin resistance and Alzheimer's disease and dementia: The Kuakini Honolulu heart program. |date=15.08.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31284182 |full-text-url=https://sci-hub.do/10.1016/j.jns.2019.06.031 }} * {{medline-title |title=Latent Classes of Cognitive Functioning Among Depressed Older Adults Without Dementia. |date=09.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31232250 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733620 }} * {{medline-title |title=Lifespan Intellectual Factors, Genetic Susceptibility, and Cognitive Phenotypes in Aging: Implications for Interventions. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31214016 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554280 }} * {{medline-title |title=Cyclic O exposure synergizes with aging leading to memory impairment in male [[APOE]] ε3, but not [[APOE]] ε4, targeted replacement mice. |date=09.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31207469 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732233 }} * {{medline-title |title=Alzheimer's disease and symbiotic microbiota: an evolutionary medicine perspective. |date=08.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31180143 |full-text-url=https://sci-hub.do/10.1111/nyas.14129 }} * {{medline-title |title=The role of [[APOE]] in transgenic mouse models of AD. |date=10.08.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31150730 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717006 }} * {{medline-title |title=Sex differences in mixed neuropathologies in community-dwelling older adults. |date=15.09.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31128096 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6636678 }} * {{medline-title |title=Women Outperform Men in Verbal Episodic Memory Even in Oldest-Old Age: 13-Year Longitudinal Results of the AgeCoDe/AgeQualiDe Study. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31127762 |full-text-url=https://sci-hub.do/10.3233/JAD-180949 }} * {{medline-title |title=[[APOE]] Effect on Amyloid-β PET Spatial Distribution, Deposition Rate, and Cut-Points. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31127775 |full-text-url=https://sci-hub.do/10.3233/JAD-181282 }} * {{medline-title |title=Sex differences in the association of [[APOE]] ε4 genotype with longitudinal hippocampal atrophy in cognitively normal older people. |date=11.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31102429 |full-text-url=https://sci-hub.do/10.1111/ene.13987 }} * {{medline-title |title=Predictors and Implications of Accelerated Cognitive Aging. |date=2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31007841 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469682 }} * {{medline-title |title=Association of Cortical β-Amyloid Protein in the Absence of Insoluble Deposits With Alzheimer Disease. |date=01.07.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31009033 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6583061 }} * {{medline-title |title=Sex differences in the association between amyloid and longitudinal brain volume change in cognitively normal older adults. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30927602 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444285 }} * {{medline-title |title=Region-specific association between basal blood insulin and cerebral glucose metabolism in older adults. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30904824 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434096 }} * {{medline-title |title=Association between [[APOE]] e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity. |date=10.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30903549 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7572345 }} * {{medline-title |title=Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging. |date=28.03.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30923322 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438979 }} * {{medline-title |title=Nuances in Alzheimer's Genetic Risk Reveal Differential Predictions of Non-demented Memory Aging Trajectories: Selective Patterns by [[APOE]] Genotype and Sex. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30873923 |full-text-url=https://sci-hub.do/10.2174/1567205016666190315094452 }} * {{medline-title |title=A prospective study of focal brain atrophy, mobility and fitness. |date=07.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30861232 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586507 }} * {{medline-title |title=10-year follow-up of the Super-Seniors Study: compression of morbidity and genetic factors. |date=28.02.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30819100 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394013 }} * {{medline-title |title=Increases in a Pro-inflammatory Chemokine, MCP-1, Are Related to Decreases in Memory Over Time. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30814948 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381047 }} * {{medline-title |title=Taste receptors, innate immunity and longevity: the case of [[TAS2R16]] gene. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30833980 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387736 }} * {{medline-title |title=The Role of [[APOE]]4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer's Disease. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30804776 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378415 }} * {{medline-title |title=The influence of tau, amyloid, alpha-synuclein, TDP-43, and vascular pathology in clinically normal elderly individuals. |date=05.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30776649 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486870 }} * {{medline-title |title=Opposing Roles of apolipoprotein E in aging and neurodegeneration. |date=02.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30760557 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374993 }} * {{medline-title |title=Effects of [[APOE]] on cognitive aging in community-dwelling older adults. |date=03.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30730162 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513314 }} * {{medline-title |title=A candidate gene study of risk for dementia in older, postmenopausal women: Results from the Women's Health Initiative Memory Study. |date=05.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30706571 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608707 }} * {{medline-title |title=Apolipoprotein E4 Mediates the Association Between Midlife Dyslipidemia and Cerebral Amyloid in Aging Women. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30689578 |full-text-url=https://sci-hub.do/10.3233/JAD-180815 }} * {{medline-title |title=Apolipoprotein E gene in physiological and pathological aging. |date=03.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30658061 |full-text-url=https://sci-hub.do/10.1016/j.mad.2019.01.005 }} * {{medline-title |title=Spatial patterns of white matter hyperintensities associated with Alzheimer's disease risk factors in a cognitively healthy middle-aged cohort. |date=24.01.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30678723 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346579 }} * {{medline-title |title=The Role of MRI Biomarkers and Their Interactions with Cognitive Status and [[APOE]] ε4 in Nondemented Elderly Subjects. |date=2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30673663 |full-text-url=https://sci-hub.do/10.1159/000495754 }} * {{medline-title |title=Longitudinal tau accumulation and atrophy in aging and alzheimer disease. |date=02.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30597624 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579738 }} * {{medline-title |title=Apolipoprotein E Genotypes, Age, Race, and Cognitive Decline in a Population Sample. |date=04.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30584655 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813761 }} * {{medline-title |title=Predictors of neurodegeneration differ between cognitively normal and subsequently impaired older adults. |date=03.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30580127 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394867 }} * {{medline-title |title=Vascular burden and [[APOE]] ε4 are associated with white matter microstructural decline in cognitively normal older adults. |date=03.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30557663 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601608 }} * {{medline-title |title=Responses to executive demand in young adulthood differ by [[APOE]] genotype. |date=15.03.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30472114 |full-text-url=https://sci-hub.do/10.1016/j.bbr.2018.11.033 }} * {{medline-title |title=Mild Cognitive Impairment that Does Not Progress to Dementia: A Population-Based Study. |date=02.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30444944 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|title=Relationship Between Amyloid-β Positivity and Progression to Mild Cognitive Impairment or Dementia over 8 Years in Cognitively Normal Older Adults. |date=2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30149452 |full-text-url=https://sci-hub.do/10.3233/JAD-180507 }} * {{medline-title |title=Lifetime Risk Factors for Functional and Cognitive Outcomes in Patients with Alzheimer's Disease. |date=2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30149448 |full-text-url=https://sci-hub.do/10.3233/JAD-180303 }} * {{medline-title |title=Microglial translational profiling reveals a convergent [[APOE]] pathway from aging, amyloid, and tau. |date=03.09.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30082275 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122978 }} * {{medline-title |title=Childhood socioeconomic status and genetic risk for poorer cognition in later life. |date=09.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30048844 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|title=[[APOE]] ε4 Modulation of Training Outcomes in Several Cognitive Domains in a Sample of Cognitively Intact Older Adults. |date=2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28550244 |full-text-url=https://sci-hub.do/10.3233/JAD-161014 }} * {{medline-title |title=[[APOE]] Genotype and Nonrespiratory Sleep Parameters in Cognitively Intact Older Adults. |date=01.08.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28482100 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804995 }} * {{medline-title |title=The [[APOE]] ε4 Allele Is Associated with Lower Selenium Levels in the Brain: Implications for Alzheimer's Disease. |date=19.07.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28453930 |full-text-url=https://sci-hub.do/10.1021/acschemneuro.7b00014 }} * {{medline-title |title=Cognitive Domain Dispersion Association with Alzheimer's Disease Pathology. |date=2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28453479 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{{medline-title |title=Neuritic and Diffuse Plaque Associations with Memory in Non-Cognitively Impaired Elderly. |date=14.07.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27540968 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314669 }} * {{medline-title |title=White matter hyperintensities are more highly associated with preclinical Alzheimer's disease than imaging and cognitive markers of neurodegeneration. |date=2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27489875 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950175 }} * {{medline-title |title=[[APOE]] ε4 allele modifies the association of lead exposure with age-related cognitive decline in older individuals. |date=11.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27474937 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071136 }} * {{medline-title |title=[[APOE]] genotype and stress response - a mini review. |date=25.07.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27457486 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near CHRNA3/5 and [[APOE]] have age- and sex-related effects on human lifespan. |date=31.03.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27029810 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438072 }} * {{medline-title |title=Age, [[APOE]] and sex: Triad of risk of Alzheimer's disease. |date=06.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26969397 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905558 }} * {{medline-title |title=Occupational cognitive requirements and late-life cognitive aging. |date=12.04.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26984944 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831043 }} * {{medline-title |title=Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease. |date=05.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26962052 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006248 }} * {{medline-title |title=Genetic landscape of [[APOE]] in human longevity revealed by high-throughput sequencing. |date=04.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26930295 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818712 }} * {{medline-title |title=No Association between Variation in Longevity Candidate Genes and Aging-related Phenotypes in Oldest-old Danes. |date=06.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26946122 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841709 }} * {{medline-title |title=Lack of neural compensatory mechanisms of [[BDNF]] val66met met carriers and [[APOE]] E4 carriers in healthy aging, mild cognitive impairment, and Alzheimer's disease. |date=03.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26923413 |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2015.12.004 }} * {{medline-title |title=Novel loci and pathways significantly associated with longevity. |date=25.02.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26912274 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|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2015.12.018 }} * {{medline-title |title=High homocysteine and epistasis between [[MTHFR]] and [[APOE]]: association with cognitive performance in the elderly. |date=04.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26774227 |full-text-url=https://sci-hub.do/10.1016/j.exger.2016.01.005 }} * {{medline-title |title=The Relationship Between Plasma Aβ Levels, Cognitive Function and Brain Volumetrics: Sydney Memory and Ageing Study. |date=2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26679856 |full-text-url=https://sci-hub.do/10.2174/1567205013666151218150202 }} * {{medline-title |title=Braak staging, plaque pathology, and [[APOE]] status in elderly persons without cognitive impairment. |date=01.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26686670 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687022 }} * {{medline-title |title=Biomarkers of cholesterol homeostasis in a clinical laboratory database sample 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detectable amyloid onset for risk factor assessment. |date=04.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26588863 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841700 }} * {{medline-title |title=Influence of amyloid and [[APOE]] on cognitive performance in a late middle-aged cohort. |date=03.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26602629 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850495 }} * {{medline-title |title=Gene-Environment Interplay in Physical, Psychological, and Cognitive Domains in Mid to Late Adulthood: Is [[APOE]] a Variability Gene? |date=01.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26538244 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858319 }} * {{medline-title |title=Predictors of Cognitive and Functional Decline in Patients With Alzheimer Disease Dementia From Brazil. |date=07-09.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26523709 |full-text-url=https://sci-hub.do/10.1097/WAD.0000000000000117 }} * {{medline-title |title=[[APOE]] Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction. |date=10.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26512759 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626092 }} * {{medline-title |title=Association of [[APOE]] with tau-tangle pathology with and without β-amyloid. |date=01.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26481403 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716785 }} * {{medline-title |title=[[APOE]] Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration. |date=07.10.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26446211 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6605380 }} * {{medline-title |title=The Role of Alzheimer's and Cerebrovascular Pathology in Mediating the Effects of Age, Race, and Apolipoprotein E Genotype on Dementia 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brain connectivity differences in early MCI and normal aging populations: an fMRI study. |date=12.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26409470 |full-text-url=https://sci-hub.do/10.1007/s11682-015-9451-z }} * {{medline-title |title=Effects of [[APOE]] rs429358, rs7412 and [[GSTM1]]/[[GSTT1]] Polymorphism on Plasma and Erythrocyte Antioxidant Parameters and Cognition in Old Chinese Adults. |date=24.09.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26404360 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632411 }} * {{medline-title |title=Does apolipoprotein E genotype influence cognition in middle-aged individuals? |date=12.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26402402 |full-text-url=https://sci-hub.do/10.1097/WCO.0000000000000262 }} * {{medline-title |title=Diabetes is Associated with Worse Executive Function in Both Eastern and Western Populations: Shanghai Aging Study and Mayo Clinic Study of Aging. |date=2015 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White Matter Integrity and Cognitive Functions in Chinese Non-Demented Elderly with the [[APOE]] ɛ4 Allele. |date=2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26402101 |full-text-url=https://sci-hub.do/10.3233/JAD-150357 }} * {{medline-title |title=Vascular Health and Genetic Risk Affect Mild Cognitive Impairment Status and 4-Year Stability: Evidence From the Victoria Longitudinal Study. |date=11.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26362601 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067948 }} * {{medline-title |title=Apolipoprotein E and Clusterin can magnify effects of personality vulnerability on declarative memory performance in non-demented older adults. |date=05.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26343804 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826141 }} * {{medline-title |title=Examining the association between Apolipoprotein E ([[APOE]]) and self-reported sleep disturbances in non-demented older adults. 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Longitudinal Cognitive Decline in Nondemented Older Subjects: Results from a Multi-Ethnic Population. |date=2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26221954 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519341 }} * {{medline-title |title=DNA methylation and single nucleotide variants in the brain-derived neurotrophic factor ([[BDNF]]) and oxytocin receptor ([[OXTR]]) genes are associated with anxiety/depression in older women. |date=2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26175754 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485183 }} * {{medline-title |title=Longitudinal cognitive decline in the AIBL cohort: The role of [[APOE]] ε4 status. |date=08.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26102189 |full-text-url=https://sci-hub.do/10.1016/j.neuropsychologia.2015.06.008 }} * {{medline-title |title=Anterior cingulate cortex mediates the relationship between O3PUFAs and executive functions in [[APOE]] e4 carriers. |date=2015 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|title=Interaction of Cigarette Smoking History With [[APOE]] Genotype and Age on Amyloid Level, Glucose Metabolism, and Neurocognition in Cognitively Normal Elders. |date=02.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25847292 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967295 }} * {{medline-title |title=[[APOE]]4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice. |date=05.03.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25871877 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391134 }} * {{medline-title |title=[[APOE]] ε4 Genotype and the Risk for Subjective Cognitive Impairment in Elderly Persons. |date=Fall.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25803305 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581892 }} * {{medline-title |title=Predicting the risk of mild cognitive impairment in the Mayo Clinic Study of Aging. |date=07.04.2015 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|date=04.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24670469 |full-text-url=https://sci-hub.do/10.1017/S1355617714000174 }} * {{medline-title |title=The benefits of staying active in old age: physical activity counteracts the negative influence of [[PICALM]], [[BIN1]], and [[CLU]] risk alleles on episodic memory functioning. |date=06.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24660791 |full-text-url=https://sci-hub.do/10.1037/a0035465 }} * {{medline-title |title=Increased hippocampal blood flow in sedentary older adults at genetic risk for Alzheimer's disease. |date=2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24685629 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259215 }} * {{medline-title |title=Atherosclerosis and Alzheimer--diseases with a common cause? Inflammation, oxysterols, vasculature. |date=21.03.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24656052 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3994432 }} * {{medline-title |title=[Clinical and genetic characteristics of long-livers in Moscow region]. |date=2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24640693 }} * {{medline-title |title=Cortical ¹¹C-PIB uptake is associated with age, [[APOE]] genotype, and gender in "healthy aging". |date=2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24603945 |full-text-url=https://sci-hub.do/10.3233/JAD-132783 }} * {{medline-title |title=Prevalence of mild cognitive impairment in an urban community in China: a cross-sectional analysis of the Shanghai Aging Study. |date=03.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24613707 |full-text-url=https://sci-hub.do/10.1016/j.jalz.2013.11.002 }} * {{medline-title |title=Cognitive and neural signatures of the [[APOE]] E4 allele in mid-aged adults. |date=07.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24582638 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001126 }} * {{medline-title |title=Mitochondrial DNA and traumatic brain injury. |date=02.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24523223 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112718 }} * {{medline-title |title=The [[APOE]] ε4 allele in relation to brain white-matter microstructure in adulthood and aging. |date=06.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24506254 |full-text-url=https://sci-hub.do/10.1111/sjop.12099 }} * {{medline-title |title=Stress, race, and [[APOE]]: understanding the interplay of risk factors for changes in cognitive functioning. |date=2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24521139 |full-text-url=https://sci-hub.do/10.1080/13607863.2014.880403 }} * {{medline-title |title=Beta-amyloid associated differential effects of [[APOE]] ε4 on brain metabolism in cognitively normal elderly. |date=10.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24495404 |full-text-url=https://sci-hub.do/10.1016/j.jagp.2013.12.173 }} * {{medline-title |title=Apolipoprotein E and depressive symptoms: shared or independent routes to age-related cognitive decline? |date=02.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24434954 |full-text-url=https://sci-hub.do/10.1097/PSY.0000000000000030 }} * {{medline-title |title=Interaction of [[APOE]] genotype and testosterone on episodic memory in middle-aged men. |date=07.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24444806 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980008 }} * {{medline-title |title=Sydney Memory and Ageing Study: an epidemiological cohort study of brain ageing and dementia. |date=12.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24423224 |full-text-url=https://sci-hub.do/10.3109/09540261.2013.860890 }} * {{medline-title |title=Basal forebrain atrophy and cortical amyloid deposition in nondemented elderly subjects. |date=10.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24418052 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092050 }} * {{medline-title |title=Interactive effects of apolipoprotein E4 and diabetes risk on later myelinating white matter regions in neurologically healthy older aged adults. |date=05.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24381137 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356251 }}
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