Редактирование: Aging genes 60-99 (раздел)

==TLR4==

* {{medline-title
|title=Age-Dependent Changes of Adipokine and Cytokine Secretion From Rat Adipose Tissue by Endogenous and Exogenous Toll-Like Receptor Agonists.
|date=2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32973755
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466552
}}
* {{medline-title
|title=Role of Toll Like Receptor 4 in Alzheimer's Disease.
|date=2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32983082
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479089
}}
* {{medline-title
|title=Commentary on Some Recent Theses Relevant to Combating Aging: August 2020.
|date=08.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32718230
|full-text-url=https://sci-hub.do/10.1089/rej.2020.2378
}}
* {{medline-title
|title=Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration.
|date=2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32581723
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296093
}}
* {{medline-title
|title=Chemerin facilitates intervertebral disc degeneration via [[TLR4]] and CMKLR1 and activation of NF-kB signaling pathway.
|date=11.06.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32526705
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343479
}}
* {{medline-title
|title=Toll-like receptor 4 differentially regulates adult hippocampal neurogenesis in an age- and sex-dependent manner.
|date=09.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32343455
|full-text-url=https://sci-hub.do/10.1002/hipo.23209
}}
* {{medline-title
|title=Aging-associated immunosenescence via alterations in splenic immune cell populations in rat.
|date=15.01.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31838133
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2019.117168
}}
* {{medline-title
|title=Leptin induces immunosenescence in human B cells.
|date=02.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31831137
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002206
}}
* {{medline-title
|title=Genetic Variation in the Magnitude and Longevity of the IgG Subclass Response to a Diphtheria-Tetanus-Acellular Pertussis (DTaP) Vaccine in Mice.
|date=20.09.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31547158
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963843
}}
* {{medline-title
|title=Rapamycin improves sevoflurane‑induced cognitive dysfunction in aged rats by mediating autophagy through the [[TLR4]]/MyD88/NF‑κB signaling pathway.
|date=10.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31432123
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755174
}}
* {{medline-title
|title=Targeting [[HMGB1]] by ethyl pyruvate ameliorates systemic lupus erythematosus and reverses the senescent phenotype of bone marrow-mesenchymal stem cells.
|date=14.07.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31303606
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660056
}}
* {{medline-title
|title=Age-dependent effect between [[MARCO]] and [[TLR4]] on PMMA particle phagocytosis by macrophages.
|date=08.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31225947
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6653467
}}
* {{medline-title
|title=Regulation of Toll-Like Receptor (TLR) Signaling Pathway by Polyphenols in the Treatment of Age-Linked Neurodegenerative Diseases: Focus on [[TLR4]] Signaling.
|date=2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31134076
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522942
}}
* {{medline-title
|title=[[TLR4]] Promotes and DAP12 Limits Obesity-Induced Osteoarthritis in Aged Female Mice.
|date=04.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31044181
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478583
}}
* {{medline-title
|title=Novel Chitohexaose Analog Protects Young and Aged mice from CLP Induced Polymicrobial Sepsis.
|date=27.02.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30814582
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393422
}}
* {{medline-title
|title=Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16 .
|date=06.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30790400
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516428
}}
* {{medline-title
|title=Budesonide, Aclidinium and Formoterol in combination limit inflammaging processes in bronchial epithelial cells exposed to cigarette smoke.
|date=04.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30659954
|full-text-url=https://sci-hub.do/10.1016/j.exger.2019.01.016
}}
* {{medline-title
|title=Aging leads to dysfunctional innate immune responses to [[TLR2]] and [[TLR4]] agonists.
|date=09.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30402800
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504629
}}
* {{medline-title
|title=Plasmalogens Inhibit Endocytosis of Toll-like Receptor 4 to Attenuate the Inflammatory Signal in Microglial Cells.
|date=05.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30128650
|full-text-url=https://sci-hub.do/10.1007/s12035-018-1307-2
}}
* {{medline-title
|title=Ablation of toll-like receptor 4 attenuates aging-induced myocardial remodeling and contractile dysfunction through NCoRI-[[HDAC1]]-mediated regulation of autophagy.
|date=06.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29660306
|full-text-url=https://sci-hub.do/10.1016/j.yjmcc.2018.04.009
}}
* {{medline-title
|title=Cryopreserved whole blood for the quantification of monocyte, T-cell and NK-cell subsets, and monocyte receptor expression by multi-color flow cytometry: A methodological study based on participants from the canadian longitudinal study on aging.
|date=05.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29624852
|full-text-url=https://sci-hub.do/10.1002/cyto.a.23372
}}
* {{medline-title
|title=Inflammation, insulin signaling and cognitive function in aged APP/PS1 mice.
|date=05.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29604345
|full-text-url=https://sci-hub.do/10.1016/j.bbi.2018.03.032
}}
* {{medline-title
|title=Repeated stimulation by LPS promotes the senescence of DPSCs via [[TLR4]]/MyD88-NF-κB-p53/p21 signaling.
|date=06.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29480340
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021280
}}
* {{medline-title
|title=Ageing potentiates diet-induced glucose intolerance, β-cell failure and tissue inflammation through [[TLR4]].
|date=09.02.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29426925
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807311
}}
* {{medline-title
|title=Fibronectin Containing Extra Domain A Induces Plaque Destabilization in the Innominate Artery of Aged Apolipoprotein E-Deficient Mice.
|date=03.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29326316
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823768
}}
* {{medline-title
|title=Granzyme A in Human Platelets Regulates the Synthesis of Proinflammatory Cytokines by Monocytes in Aging.
|date=01.01.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29167233
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5736423
}}
* {{medline-title
|title=[[TLR4]] and [[TLR2]] activation is differentially associated with age during Parkinson's disease.
|date=01.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29077524
|full-text-url=https://sci-hub.do/10.1080/08820139.2017.1379024
}}
* {{medline-title
|title=Toll-like receptor 4 ([[TLR4]]) deficient mice are protected from adipose tissue inflammation in aging.
|date=07.09.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28898202
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636669
}}
* {{medline-title
|title=Role of pattern recognition receptors of the neurovascular unit in inflamm-aging.
|date=01.11.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28801521
|full-text-url=https://sci-hub.do/10.1152/ajpheart.00106.2017
}}
* {{medline-title
|title=Exenatide mitigated diet-induced vascular aging and atherosclerotic plaque growth in ApoE-deficient mice under chronic stress.
|date=09.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28734203
|full-text-url=https://sci-hub.do/10.1016/j.atherosclerosis.2017.07.014
}}
* {{medline-title
|title=Human Monocyte Subsets Are Transcriptionally and Functionally Altered in Aging in Response to Pattern Recognition Receptor Agonists.
|date=15.08.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28696254
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548610
}}
* {{medline-title
|title=A dual agonist of farnesoid X receptor (FXR) and the G protein-coupled receptor TGR5, INT-767, reverses age-related kidney disease in mice.
|date=21.07.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28596381
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519354
}}
* {{medline-title
|title=The critical role played by endotoxin-induced liver autophagy in the maintenance of lipid metabolism during sepsis.
|date=03.07.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28575583
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529074
}}
* {{medline-title
|title=Growth performance, reproductive traits and offspring survivability of genetically modified rams overexpressing toll-like receptor 4.
|date=01.07.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28532825
|full-text-url=https://sci-hub.do/10.1016/j.theriogenology.2017.04.006
}}
* {{medline-title
|title=Increased dipeptidyl peptidase-4 accelerates diet-related vascular aging and atherosclerosis in ApoE-deficient mice under chronic stress.
|date=15.09.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28549747
|full-text-url=https://sci-hub.do/10.1016/j.ijcard.2017.05.062
}}
* {{medline-title
|title=Age-related changes and distribution of T cell markers (CD3 and [[CD4]]) and toll-like receptors(TLR2, [[TLR3]],[[TLR4]] and [[TLR7]]) in the duck lymphoid organs.
|date=07.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28356195
|full-text-url=https://sci-hub.do/10.1016/j.imbio.2017.01.004
}}
* {{medline-title
|title=Aging and amyloid β oligomers enhance [[TLR4]] expression, LPS-induced Ca  responses, and neuron cell death in cultured rat hippocampal neurons.
|date=31.01.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28143556
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282876
}}
* {{medline-title
|title=Attenuated recovery of contractile function in aging hearts following global ischemia/reperfusion: Role of extracellular HSP27 and [[TLR4]].
|date=01.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28079228
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5263054
}}
* {{medline-title
|title=Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts.
|date=02.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27845246
|full-text-url=https://sci-hub.do/10.1016/j.bbalip.2016.11.003
}}
* {{medline-title
|title=Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization.
|date=01.12.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27793997
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386828
}}
* {{medline-title
|title=Strain-dependent response to stimulation in middle-aged rat macrophages: A quest after a useful indicator of healthy aging.
|date=01.12.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27756630
|full-text-url=https://sci-hub.do/10.1016/j.exger.2016.10.005
}}
* {{medline-title
|title=Microglial response to LPS increases in wild-type mice during aging but diminishes in an Alzheimer's mouse model: Implication of [[TLR4]] signaling in disease progression.
|date=14.10.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27641666
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048480
}}
* {{medline-title
|title=Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice.
|date=08.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27578257
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061686
}}
* {{medline-title
|title=Modulation of Macrophage Polarization and [[HMGB1]]-TLR2/[[TLR4]] Cascade Plays a Crucial Role for Cardiac Remodeling in Senescence-Accelerated Prone Mice.
|date=2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27070323
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829159
}}
* {{medline-title
|title=In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant.
|date=07.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27081760
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906944
}}
* {{medline-title
|title=Effects of aerobic training on markers of autophagy in the elderly.
|date=04.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26940016
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005904
}}
* {{medline-title
|title=Reduced levels of cytosolic DNA sensor [[AIM2]] are associated with impaired cytokine responses in healthy elderly.
|date=06.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26944367
|full-text-url=https://sci-hub.do/10.1016/j.exger.2016.02.016
}}
* {{medline-title
|title=Bone biology-related gingival transcriptome in ageing and periodontitis in non-human primates.
|date=05.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26859687
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844783
}}
* {{medline-title
|title=Gut microbiota lipopolysaccharide accelerates inflamm-aging in mice.
|date=16.01.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26772806
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715324
}}
* {{medline-title
|title=Direct Regulation of [[TLR5]] Expression by Caveolin-1.
|date=12.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26615831
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697003
}}
* {{medline-title
|title=Anti-Inflamm-Aging Effects of Long-Term Caloric Restriction via Overexpression of [[SIGIRR]] to Inhibit NF-κB Signaling Pathway.
|date=2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26431348
|full-text-url=https://sci-hub.do/10.1159/000430248
}}
* {{medline-title
|title=Lead exposure induced microgliosis and astrogliosis in hippocampus of young mice potentially by triggering [[TLR4]]-MyD88-NFκB signaling cascades.
|date=03.12.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26386401
|full-text-url=https://sci-hub.do/10.1016/j.toxlet.2015.09.015
}}
* {{medline-title
|title=Monocyte Phenotype and Polyfunctionality Are Associated With Elevated Soluble Inflammatory Markers, Cytomegalovirus Infection, and Functional and Cognitive Decline in Elderly Adults.
|date=05.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26286603
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007736
}}
* {{medline-title
|title=Flagellin-dependent [[TLR5]]/caveolin-1 as a promising immune activator in immunosenescence.
|date=10.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26223660
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568978
}}
* {{medline-title
|title=Decreased serum level of [[HMGB1]] and MyD88 during human aging progress in healthy individuals.
|date=04.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26130428
|full-text-url=https://sci-hub.do/10.1007/s40520-015-0402-8
}}
* {{medline-title
|title=The stimulatory effect of the [[TLR4]]-mediated adjuvant glucopyranosyl lipid A is well preserved in old age.
|date=02.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25957253
|full-text-url=https://sci-hub.do/10.1007/s10522-015-9576-x
}}
* {{medline-title
|title=Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium.
|date=06.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25963977
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450138
}}
* {{medline-title
|title=Bone marrow-derived macrophages from aged rats are more responsive to inflammatory stimuli.
|date=09.04.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25890218
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397943
}}
* {{medline-title
|title=Cathelicidin related antimicrobial peptide, laminin, Toll-like receptors and chemokines levels in experimental hypersensitivity pneumonitis in mice.
|date=06.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25834936
|full-text-url=https://sci-hub.do/10.1016/j.patbio.2015.03.002
}}
* {{medline-title
|title=Prophylactic lithium alleviates splenectomy-induced cognitive dysfunction possibly by inhibiting hippocampal [[TLR4]] activation in aged rats.
|date=05.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25839444
|full-text-url=https://sci-hub.do/10.1016/j.brainresbull.2015.02.008
}}
* {{medline-title
|title=Altered neutrophil functions in elderly patients during a 6-month follow-up period after a hip fracture.
|date=05.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25797136
|full-text-url=https://sci-hub.do/10.1016/j.exger.2015.03.009
}}
* {{medline-title
|title=Aging does not affect the ability of human monocyte-derived dendritic cells to phagocytose Candida albicans.
|date=12.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25783173
|full-text-url=https://sci-hub.do/10.1007/s40520-015-0344-1
}}
* {{medline-title
|title=Aging oppositely affects [[TNF]]-α and IL-10 production by macrophages from different rat strains.
|date=2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25009084
|full-text-url=https://sci-hub.do/10.1007/s10522-014-9513-4
}}
* {{medline-title
|title=Bacteria and Toll-like receptor and cytokine mRNA expression profiles associated with canine arthritis.
|date=15.08.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24856731
|full-text-url=https://sci-hub.do/10.1016/j.vetimm.2014.04.004
}}
* {{medline-title
|title=Elevated muscle [[TLR4]] expression and metabolic endotoxemia in human aging.
|date=02.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24846769
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311182
}}
* {{medline-title
|title=Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals.
|date=08.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24779584
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326942
}}