Редактирование: Aging genes 30-59 (раздел)

==IGF1==

* {{medline-title
|title=Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice.
|date=11.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33105070
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681063
}}
* {{medline-title
|title=17α-estradiol modulates [[IGF1]] and hepatic gene expression in a sex-specific manner.
|date=28.08.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32857104
|full-text-url=https://sci-hub.do/10.1093/gerona/glaa215
}}
* {{medline-title
|title=Pan-mammalian analysis of molecular constraints underlying extended lifespan.
|date=11.02.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32043462
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012612
}}
* {{medline-title
|title=17α-Estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates.
|date=01.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31698046
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6911620
}}
* {{medline-title
|title=Reducing [[INS]]-[[IGF1]] signaling protects against non-cell autonomous vesicle rupture caused by [[SNCA]] spreading.
|date=05.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31354022
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144869
}}
* {{medline-title
|title=Are There Common Mechanisms Between the Hutchinson-Gilford Progeria Syndrome and Natural Aging?
|date=2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31156709
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529819
}}
* {{medline-title
|title=Lactoferrin ameliorates aging-suppressed osteogenesis via [[IGF1]] signaling.
|date=07.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31125976
|full-text-url=https://sci-hub.do/10.1530/JME-19-0003
}}
* {{medline-title
|title=[i][[TP53]][/i] Tumor-suppressor Gene Plays a Key Role in [[IGF1]] Signaling Pathway Related to the Aging of Human Melanocytes.
|date=05.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31092438
|full-text-url=https://sci-hub.do/10.21873/anticanres.13363
}}
* {{medline-title
|title=Involvement of insulin receptor substrates in cognitive impairment and Alzheimer's disease.
|date=08.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30964050
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524492
}}
* {{medline-title
|title=In mice transgenic for [[IGF1]] under keratin-14 promoter, lifespan is decreased and the rates of aging and thymus involution are accelerated.
|date=13.04.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30981207
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503882
}}
* {{medline-title
|title=[[IGF1]] Gene Therapy Modifies Microglia in the Striatum of Senile Rats.
|date=2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30890930
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411822
}}
* {{medline-title
|title=Novel biomolecules of ageing, sex differences and potential underlying mechanisms of telomere shortening in coronary artery disease.
|date=05.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30684534
|full-text-url=https://sci-hub.do/10.1016/j.exger.2019.01.020
}}
* {{medline-title
|title=Growth signaling and longevity in mouse models.
|date=01.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30545442
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386229
}}
* {{medline-title
|title=IGF-1 Gene Therapy as a Potentially Useful Therapy for Spontaneous Prolactinomas in Senile Rats.
|date=2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30198429
|full-text-url=https://sci-hub.do/10.2174/1566523218666180905170020
}}
* {{medline-title
|title=A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup.
|date=12.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30151729
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294728
}}
* {{medline-title
|title=Matrine induces senescence of human glioblastoma cells through suppression of the [[IGF1]]/PI3K/AKT/p27 signaling pathway.
|date=09.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30079478
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6143938
}}
* {{medline-title
|title=Composition and richness of the serum microbiome differ by age and link to systemic inflammation.
|date=06.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29869736
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060185
}}
* {{medline-title
|title=40 YEARS of [[IGF1]]: [[IGF1]]: the Jekyll and Hyde of the aging brain.
|date=07.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29739805
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988994
}}
* {{medline-title
|title=De-silencing [i]Grb10[/i] contributes to acute ER stress-induced steatosis in mouse liver.
|date=05.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29555819
|full-text-url=https://sci-hub.do/10.1530/JME-18-0018
}}
* {{medline-title
|title=Long-lived rodents reveal signatures of positive selection in genes associated with lifespan.
|date=03.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29570707
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884551
}}
* {{medline-title
|title=Activation of DAF-16/FOXO by reactive oxygen species contributes to longevity in long-lived mitochondrial mutants in Caenorhabditis elegans.
|date=03.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29522556
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862515
}}
* {{medline-title
|title=Withanolide A extends the lifespan in human [[EGFR]]-driven cancerous Caenorhabditis elegans.
|date=04.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29427754
|full-text-url=https://sci-hub.do/10.1016/j.exger.2018.02.004
}}
* {{medline-title
|title=Caloric restriction stabilizes body weight and accelerates behavioral recovery in aged rats after focal ischemia.
|date=12.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28961383
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676058
}}
* {{medline-title
|title=Molecular signatures of longevity: Insights from cross-species comparative studies.
|date=10.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28800931
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807068
}}
* {{medline-title
|title=The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover.
|date=20.04.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28431247
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406386
}}
* {{medline-title
|title=Life-span Extension With Reduced Somatotrophic Signaling: Moderation of Aging Effect by Signal Type, Sex, and Experimental Cohort.
|date=09.11.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28207064
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861954
}}
* {{medline-title
|title=Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging.
|date=2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28203146
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5285390
}}
* {{medline-title
|title=Changes in Communication between Muscle Stem Cells and their Environment with Aging.
|date=02.09.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27858742
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240546
}}
* {{medline-title
|title=Role of Bone Marrow Maturity, Insulin-Like Growth Factor 1 Receptor, and Forkhead Box Protein N1 in Thymic Involution and Rejuvenation.
|date=10.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27145342
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097038
}}
* {{medline-title
|title=Effects of Metabolic Programming on Juvenile Play Behavior and Gene Expression in the Prefrontal Cortex of Rats.
|date=2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26967530
|full-text-url=https://sci-hub.do/10.1159/000444015
}}
* {{medline-title
|title=Apoptosis during embryonic tissue remodeling is accompanied by cell senescence.
|date=11.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26568417
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694067
}}
* {{medline-title
|title=Telomerase activity promotes osteoblast differentiation by modulating IGF-signaling pathway.
|date=12.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26260615
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602053
}}
* {{medline-title
|title=Exercise does not enhance aged bone's impaired response to artificial loading in C57Bl/6 mice.
|date=12.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26142929
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652609
}}
* {{medline-title
|title=Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the cortex.
|date=07.07.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26100875
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4500222
}}
* {{medline-title
|title=Aerobic Exercise Recovers Disuse-induced Atrophy Through the Stimulus of the LRP130/[[PGC]]-1α Complex in Aged Rats.
|date=05.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25991827
|full-text-url=https://sci-hub.do/10.1093/gerona/glv064
}}
* {{medline-title
|title=Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver.
|date=03.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25855408
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394730
}}
* {{medline-title
|title=Insulin-like growth factor 1, glycation and bone fragility: implications for fracture resistance of bone.
|date=2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25629402
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309541
}}
* {{medline-title
|title=Comparison of rapamycin schedules in mice on high-fat diet.
|date=2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25485580
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614913
}}
* {{medline-title
|title=Growth hormone abolishes beneficial effects of calorie restriction in long-lived Ames dwarf mice.
|date=10.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25152388
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252511
}}
* {{medline-title
|title=A randomised controlled trial evaluating [[IGF1]] titration in contrast to current GH dosing strategies in children born small for gestational age: the North European Small-for-Gestational-Age Study.
|date=10.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25080293
|full-text-url=https://sci-hub.do/10.1530/EJE-14-0419
}}
* {{medline-title
|title=Human [[IGF1]] regulates midgut oxidative stress and epithelial homeostasis to balance lifespan and Plasmodium falciparum resistance in Anopheles stephensi.
|date=06.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24968248
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072789
}}
* {{medline-title
|title=Could different treatment approaches in acromegaly influence life expectancy? A comparative study between Bulgaria and Campania (Italy).
|date=08.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24878680
|full-text-url=https://sci-hub.do/10.1530/EJE-13-1022
}}
* {{medline-title
|title=Insulin and insulin-like growth factor receptors in the brain: physiological and pathological aspects.
|date=12.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24529663
|full-text-url=https://sci-hub.do/10.1016/j.euroneuro.2014.01.020
}}
* {{medline-title
|title=Selective manipulation of aging: a novel strategy for the treatment of neurodegenerative disorders.
|date=13.02.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24526357
|full-text-url=https://sci-hub.do/10.4414/smw.2014.13917
}}