Редактирование: Aging genes 20-29 (раздел)

==LRRK2==

* {{medline-title
|title=Aberrant mitochondrial morphology and function associated with impaired mitophagy and [[DNM1L]]-MAPK/ERK signaling are found in aged mutant Parkinsonian [[LRRK2]]  mice.
|date=10.12.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33300446
|full-text-url=https://sci-hub.do/10.1080/15548627.2020.1850008
}}
* {{medline-title
|title=Accelerated telomere shortening independent of [[LRRK2]] variants in Chinese patients with Parkinson's disease.
|date=29.10.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33122450
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655166
}}
* {{medline-title
|title=Attenuation of epigenetic regulator [[SMARCA4]] and ERK-ETS signaling suppresses aging-related dopaminergic degeneration.
|date=09.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32749068
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7511865
}}
* {{medline-title
|title=The effect of [[LRRK2]] loss-of-function variants in humans.
|date=06.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32461697
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303015
}}
* {{medline-title
|title=Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging.
|date=19.02.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32075681
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031993
}}
* {{medline-title
|title=Autophagy and [[LRRK2]] in the Aging Brain.
|date=2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31920513
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928047
}}
* {{medline-title
|title=SerThr-PhosphoProteome of Brain from Aged [[PINK1]]-KO A53T-[[SNCA]] Mice Reveals pT1928-[[MAP1B]] and pS3781-[[ANK2]] Deficits, as Hub between Autophagy and Synapse Changes.
|date=04.07.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31277379
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651490
}}
* {{medline-title
|title=Age-dependent accumulation of oligomeric [[SNCA]]/α-synuclein from impaired degradation in mutant [[LRRK2]] knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA).
|date=02.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30983487
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984454
}}
* {{medline-title
|title=A Neuron-Glial Trans-Signaling Cascade Mediates [[LRRK2]]-Induced Neurodegeneration.
|date=12.02.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30759389
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474846
}}
* {{medline-title
|title=Upregulation of the p53-p21 pathway by G2019S [[LRRK2]] contributes to the cellular senescence and accumulation of α-synuclein.
|date=02.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30712480
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422450
}}
* {{medline-title
|title=G2019S [[LRRK2]] mutation facilitates α-synuclein neuropathology in aged mice.
|date=12.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30172844
|full-text-url=https://sci-hub.do/10.1016/j.nbd.2018.08.018
}}
* {{medline-title
|title=The Enzymatic Core of the Parkinson's Disease-Associated Protein [[LRRK2]] Impairs Mitochondrial Biogenesis in Aging Yeast.
|date=2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29977190
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021522
}}
* {{medline-title
|title=Age-related pathology after adenoviral overexpression of the leucine-rich repeat kinase 2 in the mouse striatum.
|date=06.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29550548
|full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2018.02.008
}}
* {{medline-title
|title=[[LRRK2]] G2019S Induces Anxiety/Depression-like Behavior before the Onset of Motor Dysfunction with 5-HT  Receptor Upregulation in Mice.
|date=14.02.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29305532
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705874
}}
* {{medline-title
|title=Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK-Deficient Mice.
|date=15.11.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29056298
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693787
}}
* {{medline-title
|title=Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in [[LRRK2]] G2019S knock-in mice.
|date=20.09.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28930069
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633343
}}
* {{medline-title
|title=Suppression of neuroinflammation by matrix metalloproteinase-8 inhibitor in aged normal and [[LRRK2]] G2019S Parkinson's disease model mice challenged with lipopolysaccharide.
|date=18.11.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28958936
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2017.09.129
}}
* {{medline-title
|title=Progression of pathology in [[PINK1]]-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation.
|date=02.08.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28768533
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5541666
}}
* {{medline-title
|title=Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S [[LRRK2]] mice.
|date=14.03.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28292328
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351259
}}
* {{medline-title
|title=Combined [[LRRK2]] mutation, aging and chronic low dose oral rotenone as a model of Parkinson's disease.
|date=18.01.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28098219
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241661
}}
* {{medline-title
|title=[[LRRK2]] BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.
|date=01.03.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26744332
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754049
}}
* {{medline-title
|title=Functional and Morphological Correlates in the Drosophila [[LRRK2]] loss-of-function Model of Parkinson's Disease: Drug Effects of Withania somnifera (Dunal) Administration.
|date=2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26727265
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699764
}}
* {{medline-title
|title=G2019S [[LRRK2]] and aging confer susceptibility to proteasome inhibitor-induced neurotoxicity in nigrostriatal dopaminergic system.
|date=12.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26253900
|full-text-url=https://sci-hub.do/10.1007/s00702-015-1438-9
}}
* {{medline-title
|title=An early axonopathy in a h[[LRRK2]](R1441G) transgenic model of Parkinson disease.
|date=10.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26192625
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640977
}}
* {{medline-title
|title=Mutations in [[LRRK2]] potentiate age-related impairment of autophagic flux.
|date=11.07.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26159606
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702340
}}
* {{medline-title
|title=[11C]PBR28 PET imaging is sensitive to neuroinflammation in the aged rat.
|date=08.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25833342
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528008
}}
* {{medline-title
|title=Changes in actin dynamics and F-actin structure both in synaptoneurosomes of [[LRRK2]](R1441G) mutant mice and in primary human fibroblasts of [[LRRK2]](G2019S) mutation carriers.
|date=22.01.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25301747
|full-text-url=https://sci-hub.do/10.1016/j.neuroscience.2014.09.070
}}
* {{medline-title
|title=Genetic and pharmacological evidence that G2019S [[LRRK2]] confers a hyperkinetic phenotype, resistant to motor decline associated with aging.
|date=11.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25107341
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194318
}}