Редактирование: Публикации о генах и старении (titles) (раздел)

==CD4==

{{medline-entry
|title=Identification of Key Genes and Potential New Biomarkers for Ovarian Aging: A Study Based on RNA-Sequencing Data.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33304387


|keywords=* GEO database
* bioinformatics
* biomarker
* immune cell infiltration
* ovarian aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701310
}}
{{medline-entry
|title=Distinct Age-Related Epigenetic Signatures in [[CD4]] and CD8 T Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33262764


|keywords=* T-cell
* T-cell homeostasis
* aging
* chromatin accessibility
* epigenetics
* ribosomal proteins
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686576
}}
{{medline-entry
|title=IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A Foxp3  Cells During Mucosal Infection and Is Dysregulated With Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33240286


|keywords=* Candida
* Foxp3
* IL-1β
* Treg
* Treg17
* aging
* fungal infection
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677307
}}
{{medline-entry
|title=Thymus involution sets the clock of declined immunity and repair with aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33248315


|keywords=* Aging
* Chronic systemic inflammation
* Dysregulated CD4 T cells
* Immune-mediated repair
* Thymus
|full-text-url=https://sci-hub.do/10.1016/j.arr.2020.101231
}}
{{medline-entry
|title=Food insecurity and T-cell dysregulation in women living with HIV on antiretroviral therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33247896


|keywords=* HIV
* exhaustion
* food insecurity
* immune activation
* senescence
|full-text-url=https://sci-hub.do/10.1093/cid/ciaa1771
}}
{{medline-entry
|title=Rapamycin Eyedrops Increased [[CD4]] Foxp3  Cells and Prevented Goblet Cell Loss in the Aged Ocular Surface.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33255287


|keywords=* aging
* dry eye
* goblet cell
* inflammation
* lacrimal gland
* ocular surface
* rapamycin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727717
}}
{{medline-entry
|title=Antioxidants N-Acetylcysteine and Vitamin C Improve T Cell Commitment to Memory and Long-Term Maintenance of Immunological Memory in Old Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33228213


|keywords=* NAC
* T cells
* aging
* antioxidants
* immunosenescence
* vaccination
* vitamin C
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7699597
}}
{{medline-entry
|title=Evolution of comorbidities in people living with HIV between 2004 and 2014: cross-sectional analyses from ANRS CO3 Aquitaine cohort.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33198667


|keywords=* Aging
* Cardiovascular events
* Chronic kidney disease
* Comorbidities
* HIV
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670698
}}
{{medline-entry
|title=Impact of age on [[CD4]] recovery and viral suppression over time among adults living with HIV who initiated antiretroviral therapy in the African Cohort Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33183355


|keywords=* Elders on antiretroviral drugs
* HIV and aging
* HIV treatment outcomes
* Sub-saharan Africa
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664082
}}
{{medline-entry
|title=hPMSCs protects against D-galactose-induced oxidative damage of [[CD4]]  T cells through activating Akt-mediated Nrf2 antioxidant signaling.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33148324


|keywords=* Aging
* CD4+ T cells
* Nrf2
* Oxidative stress
* Senescence-associated secretoryphenotype
* hPMSC
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641865
}}
{{medline-entry
|title=Substantial gap in primary care: older adults with HIV presenting late to care.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33129258


|keywords=* Aging population
* HIV
* Older adults
* Risk
* Stigma
* Testing
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603686
}}
{{medline-entry
|title=Quantitative Digitography Measures Fine Motor Disturbances in Chronically Treated HIV Similar to Parkinson's Disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33132893


|keywords=* HIV—human immunodeficiency virus
* Parkinson’s disease
* aging
* fine motor activities
* motor control
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575770
}}
{{medline-entry
|title=Monocyte and T Cell Immune Phenotypic Profiles Associated With Age Advancement Differ Between People With HIV, Lifestyle-Comparable Controls and Blood Donors.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33123168


|keywords=* HIV
* T cell
* aging
* immune activation
* immune dysfunction
* inflammation
* monocyte
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573236
}}
{{medline-entry
|title=HIV and three dimensions of Wisdom: Association with cognitive function and physical and mental well-being: For: Psychiatry Research.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33096437


|keywords=* Affective
* Aging
* Aids
* Compassion
* Reflective
|full-text-url=https://sci-hub.do/10.1016/j.psychres.2020.113510
}}
{{medline-entry
|title=CD8  T cells are present at low levels in the white matter with physiological and pathological aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33049712


|keywords=* aging
* neuroscience
* pathology
|full-text-url=https://sci-hub.do/10.18632/aging.104043
}}
{{medline-entry
|title=Immunotherapy in older patients with cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33041248


|keywords=* Ageing
* Cancer
* Elderly
* Immunosenescence
* Immunotherapy
* Old people
* Oncogeriatry
|full-text-url=https://sci-hub.do/10.1016/j.bj.2020.07.009
}}
{{medline-entry
|title=Multiple genetic programs contribute to [[CD4]] T cell memory differentiation and longevity by maintaining T cell quiescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32987276


|keywords=* CD4 T cell
* Cell longevity
* Gene
* Genetic programs
* Memory T cell
* Memory cell markers
|full-text-url=https://sci-hub.do/10.1016/j.cellimm.2020.104210
}}
{{medline-entry
|title=Conventional Treatment for Multiple Myeloma Drives Premature Aging Phenotypes and Metabolic Dysfunction in T Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33013907


|keywords=* T cell
* aging
* autologous stem cell transplant
* metabolism
* myeloma
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494758
}}
{{medline-entry
|title=Immunosenescence: the role of age in multiple sclerosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32962809


|keywords=* Ageing
* Envejecimiento
* Esclerosis múltiple
* Esclerosis múltiple de comienzo tardío
* Immunosenescence
* Inmunosenescencia
* Late-onset multiple sclerosis
* Multiple sclerosis
|full-text-url=https://sci-hub.do/10.1016/j.nrl.2020.05.016
}}
{{medline-entry
|title=Umbilical cord mesenchymal stem cells protect thymus structure and function in aged C57 mice by downregulating aging-related genes and upregulating autophagy- and anti-oxidative stress-related genes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32924972


|keywords=* aged
* senescence
* thymus
* transplantation
* umbilical cord mesenchymal stem cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521525
}}
{{medline-entry
|title=Impaired Cytotoxic CD8  T Cell Response in Elderly COVID-19 Patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32948688

|mesh-terms=* Aged, 80 and over
* Antigens, CD
* Betacoronavirus
* CD4-Positive T-Lymphocytes
* CD8-Positive T-Lymphocytes
* COVID-19
* Coronavirus Infections
* Cytotoxins
* Female
* Humans
* Immunity, Cellular
* Male
* Middle Aged
* Pandemics
* Pneumonia, Viral
* SARS-CoV-2
* T-Lymphocyte Subsets
* T-Lymphocytes, Cytotoxic
|keywords=* CD4+

* CD8+

* COVID-19
* PD-1
* SARS-CoV-2
* aging
* cytotoxic T cells
* granzyme
* perforin
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502863
}}
{{medline-entry
|title=What are the roles of antibodies versus a durable, high quality T-cell response in protective immunity against SARS-CoV-2?
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32875286


|keywords=* Antibodies
* Antibody-dependent enhancement
* CD8 T-cells
* COVID-19
* Durable immunity
* Protective immunity
* SARS
* SARS-CoV-2
* T cell lifespan
* T-cell epitopes
* T-cells
* Vaccines
* Yellow Fever Vaccine
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452821
}}
{{medline-entry
|title=Per2 Upregulation in Circulating Hematopoietic Progenitor Cells During Chronic HIV Infection.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32850472


|keywords=* HIV
* Sirtuin 1
* hematopoietic progenitor cells
* period circadian clock 2
* senescence
* telomere length
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396677
}}
{{medline-entry
|title=COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32802142


|keywords=* ACE2
* C-reactive protein
* COVID-19
* Immunity
* Immunosenescence
* Interleukin-6
* Lymphocytes
* Renin-angiotensin system
* Severe acute respiratory syndrome coronavirus 2
* Spain
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7426672
}}
{{medline-entry
|title=Immunosenescence profiles are not associated with muscle strength, physical performance and sarcopenia risk in very old adults: The Newcastle 85+ Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32735896


|keywords=* immunosenescence
* lymphocyte compartments
* physical performance
* sarcopenia
* very old adults
|full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111321
}}
{{medline-entry
|title=Homeostasis and the functional roles of [[CD4]]  Treg cells in aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32717201


|keywords=* Aging
* Autoimmunity
* Cancer
* FOXP3
* Immune senescence
* Immune suppression
* Inflammaging
* Regulatory T cells
* T helper 17
* Treg
|full-text-url=https://sci-hub.do/10.1016/j.imlet.2020.07.004
}}
{{medline-entry
|title=A Comprehensive Evaluation of the Impact of Bovine Milk Containing Different Beta-Casein Profiles on Gut Health of Ageing Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32707687


|keywords=* A2 beta-casein
* SCFAs
* elderly
* gut inflammation
* gut microbiota
* gut morphology
* immunosenescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400800
}}
{{medline-entry
|title=Premature aging of circulating T cells predicts all-cause mortality in hemodialysis patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32660510


|keywords=* Hemodialysis
* Inflammation
* Mortality
* T cell aging
* naïve T cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359274
}}
{{medline-entry
|title=In-depth immune cellular profiling reveals sex-specific associations with frailty.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32582361


|keywords=* Frailty
* Healthy aging
* Immune cellular profiling
* Immune homeostasis
* Immunosenescence
* Sex-specific immune profile
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310472
}}
{{medline-entry
|title=CD70 contributes to age-associated T cell defects and overwhelming inflammatory responses.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32559178


|keywords=* CD70
* T cell aging
* co-inhibitory molecules
* immunosenescence
* overwhelming inflammatory responses
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7343466
}}
{{medline-entry
|title=Comparison of Overall and Comorbidity-Free Life Expectancy Between Insured Adults With and Without HIV Infection, 2000-2016.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32539152

|mesh-terms=* Adult
* Chronic Disease
* Cohort Studies
* Comorbidity
* Female
* HIV Infections
* Humans
* Insurance, Health
* Life Expectancy
* Male
* Middle Aged

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296391
}}
{{medline-entry
|title=Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32545199


|keywords=* aging
* dry eye
* inflammation
* lacrimal glands
* meibomian glands
* oxidative stress
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313015
}}
{{medline-entry
|title=Thymus aging in mice deficient in either EphB2 or EphB3, two master regulators of thymic epithelium development.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32506584


|keywords=* senescence
* thymic epithelial cells
* thymocytes
|full-text-url=https://sci-hub.do/10.1002/dvdy.212
}}
{{medline-entry
|title=CD8  T-cell senescence and skewed lymphocyte subsets in young Dyskeratosis Congenita patients with PARN and DKC1 mutations.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32452087


|keywords=* 
DKC1

* 
PARN

* Dyskeratosis Congenita
* primary immunodeficiency
* senescence
* telomere
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521304
}}
{{medline-entry
|title=Short-Term Environmental Enrichment is a Stronger Modulator of Brain Glial Cells and Cervical Lymph Node T Cell Subtypes than Exercise or Combined Exercise and Enrichment.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32451728


|keywords=* Aging
* Astrocytes
* Environmental enrichment
* Microglia
* Physical exercise
* T cells
|full-text-url=https://sci-hub.do/10.1007/s10571-020-00862-x
}}
{{medline-entry
|title=Viral and host factors related to the clinical outcome of COVID-19.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32434211

|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Animals
* Asymptomatic Infections
* Betacoronavirus
* COVID-19
* China
* Cohort Studies
* Coronavirus Infections
* Critical Illness
* Disease Progression
* Evolution, Molecular
* Female
* Genetic Variation
* Genome, Viral
* Hospitalization
* Host-Pathogen Interactions
* Humans
* Inflammation Mediators
* Interleukin-6
* Interleukin-8
* Lymphocyte Count
* Lymphopenia
* Male
* Middle Aged
* Pandemics
* Phylogeny
* Pneumonia, Viral
* Respiratory Distress Syndrome
* SARS-CoV-2
* T-Lymphocytes
* Time Factors
* Treatment Outcome
* Virulence
* Virus Shedding
* Young Adult
* Zoonoses

|full-text-url=https://sci-hub.do/10.1038/s41586-020-2355-0
}}
{{medline-entry
|title=Use of comedications and potential drug-drug interactions in people living with HIV in China.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32354599


|keywords=* Aging
* China
* Co-medication
* Drug-drug interaction
* HIV
|full-text-url=https://sci-hub.do/10.1016/j.jiac.2020.04.003
}}
{{medline-entry
|title=[[CD4]]  T helper 17 cell response of aged mice promotes prostate cancer cell migration and invasion.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32356608

|mesh-terms=* Aging
* Animals
* CD4-Positive T-Lymphocytes
* Cell Differentiation
* Cell Line, Tumor
* Cell Movement
* Humans
* Inflammation
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Models, Animal
* NF-kappa B
* Neoplasm Invasiveness
* PC-3 Cells
* Prostatic Neoplasms
* Th17 Cells
|keywords=* CD4+ T cell-secreted factors
* PCa cells
* Th17 cytokines
* aging
* inflammation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310589
}}
{{medline-entry
|title=The Rules of Human T Cell Fate [i]in vivo[/i].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32322253


|keywords=* decision
* fate
* half-life
* labeling
* lifespan
* lymphocyte
* mathematical model
* proliferation
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156550
}}
{{medline-entry
|title=[[CD4]]/CD8 ratio, comorbidities, and aging in treated HIV infected individuals on viral suppression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32314818


|keywords=* CD4/CD8 ratio
* HIV
* aging
* comorbidities
|full-text-url=https://sci-hub.do/10.1002/jmv.25911
}}
{{medline-entry
|title=The effects of advanced maternal age on T-cell subsets at the maternal-fetal interface prior to term labor and in the offspring: a mouse study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32279324

|mesh-terms=* Adult
* Aging
* Animals
* Female
* Humans
* Live Birth
* Mice
* Mice, Transgenic
* Placenta
* Pregnancy
* T-Lymphocyte Subsets
|keywords=* birth weight
* neonate
* offspring
* pregnancy
* preterm labor
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290081
}}
{{medline-entry
|title=Structural and Functional Changes in the Mesenteric Lymph Nodes in Humans during Aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32248450


|keywords=* age-related involution
* aging
* immune system
* immunomorphology
* mesenteric lymph nodes
|full-text-url=https://sci-hub.do/10.1007/s10517-020-04782-0
}}
{{medline-entry
|title=Neurocognitive Functioning is Associated with Self-Reported and Performance-Based Treatment Management Abilities in People Living with HIV with Low Health Literacy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32090235

|mesh-terms=* Adult
* Cognition
* Cross-Sectional Studies
* HIV Infections
* Health Literacy
* Humans
* Neuropsychological Tests
* Self Report
|keywords=* Adherence
* Aging
* Cognitive impairment
* HIV/AIDS
* Health illiteracy
* Observational study
|full-text-url=https://sci-hub.do/10.1093/arclin/acaa005
}}
{{medline-entry
|title=Blockade of Stat3 oncogene addiction induces cellular senescence and reveals a cell-nonautonomous activity suitable for cancer immunotherapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32064174


|keywords=* Stat3
* immune checkpoint blockade
* immunotherapy
* oncogene addiction
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996562
}}
{{medline-entry
|title=Age-related changes in T lymphocytes of patients with head and neck squamous cell carcinoma.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32082401


|keywords=* Aging
* Head and neck cancer
* Immune escape
* Immunosenescence
* T cells
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017629
}}
{{medline-entry
|title=Immunological history governs human stem cell memory [[CD4]] heterogeneity via the Wnt signaling pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32041953

|mesh-terms=* Aging
* Animals
* Antigens, CD
* CD4-Positive T-Lymphocytes
* Gene Expression Profiling
* HIV Infections
* Humans
* Immunologic Memory
* Intercellular Signaling Peptides and Proteins
* Mice
* Precursor Cells, T-Lymphoid
* Thymus Gland
* Wnt Signaling Pathway
* beta Catenin

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010798
}}
{{medline-entry
|title=Estimating HIV Management and Comorbidity Costs Among Aging HIV Patients in the United States: A Systematic Review.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32011956

|mesh-terms=* Anti-HIV Agents
* CD4 Lymphocyte Count
* Comorbidity
* Cost-Benefit Analysis
* HIV Infections
* Health Care Costs
* Humans
* Life Expectancy
* United States

|full-text-url=https://sci-hub.do/10.18553/jmcp.2020.26.2.104
}}
{{medline-entry
|title=Sex Differences in People Aging With HIV.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32032279

|mesh-terms=* Aged
* Aging
* Alcohol Drinking
* Body Composition
* CD4 Lymphocyte Count
* CD4-CD8 Ratio
* CD4-Positive T-Lymphocytes
* Cohort Studies
* Cross-Sectional Studies
* Female
* Frailty
* HIV Infections
* Humans
* Male
* Middle Aged
* Muscle Strength
* Prospective Studies

|full-text-url=https://sci-hub.do/10.1097/QAI.0000000000002259
}}
{{medline-entry
|title=Identification of Differentially Expressed miRNAs in the Response of Spleen [[CD4]]  T Cells to Electroacupuncture in Senescence-Accelerated Mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32026263

|mesh-terms=* Aging
* Animals
* Antagomirs
* CD4-Positive T-Lymphocytes
* Cell Differentiation
* Cytokines
* Down-Regulation
* Electroacupuncture
* Female
* Gene Regulatory Networks
* High-Throughput Nucleotide Sequencing
* Male
* Mice
* Mice, Inbred C57BL
* MicroRNAs
* Sequence Analysis, RNA
* Spleen
* Up-Regulation
|keywords=* CD4+ T cell
* Deep sequencing
* Electroacupuncture
* Immunological aging
* miRNA
|full-text-url=https://sci-hub.do/10.1007/s12013-020-00900-x
}}
{{medline-entry
|title=Thymus Involution and Intravenous Drug Abuse.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32000220

|mesh-terms=* Adolescent
* Adult
* Aging
* Atrophy
* CD4-Positive T-Lymphocytes
* CD8-Positive T-Lymphocytes
* Calcinosis
* Case-Control Studies
* Drug Users
* Female
* Forensic Pathology
* Hepatitis C, Chronic
* Humans
* Male
* Middle Aged
* Substance Abuse, Intravenous
* Thymus Gland
* Young Adult

|full-text-url=https://sci-hub.do/10.1097/PAF.0000000000000530
}}
{{medline-entry
|title=Depletion of [[CD4]] T cells provides therapeutic benefits in aged mice after ischemic stroke.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31954116

|mesh-terms=* Aging
* Animals
* Behavior, Animal
* Brain Chemistry
* Brain Ischemia
* CD4-Positive T-Lymphocytes
* Chemokines
* Cytokines
* Female
* Infarction, Middle Cerebral Artery
* Inflammation
* Male
* Mice
* Mice, Inbred C57BL
* Stroke
* Treatment Outcome
|keywords=* Age
* CD4 T cells
* CXCL10
* Inflammation
* Stroke
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059209
}}
{{medline-entry
|title=Immunological and Virological Responses in Older HIV-Infected Adults Receiving Antiretroviral Therapy: An Evidence-Based Meta-Analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31913990

|mesh-terms=* Aged
* Aging
* Anti-HIV Agents
* HIV Infections
* Humans
* Middle Aged

|full-text-url=https://sci-hub.do/10.1097/QAI.0000000000002266
}}
{{medline-entry
|title=African Mitochondrial DNA Haplogroup L2 Is Associated With Slower Decline of β-cell Function and Lower Incidence of Diabetes Mellitus in Non-Hispanic, Black Women Living With Human Immunodeficiency Virus.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31927570


|keywords=* HIV
* aging
* diabetes mellitus
* mitochondrial genetics
|full-text-url=https://sci-hub.do/10.1093/cid/ciaa026
}}
{{medline-entry
|title=DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31893939

|mesh-terms=* Aged
* Aging
* Animals
* Antihypertensive Agents
* CD4-Positive T-Lymphocytes
* Cyclic AMP-Dependent Protein Kinases
* Cytokines
* Humans
* Hypertension
* Mice
* Mice, Inbred C57BL
* Nedd4 Ubiquitin Protein Ligases
* Prostaglandin D2
* Receptors, Prostaglandin
* Signal Transduction
* Sp1 Transcription Factor
* Superoxides
* T-Box Domain Proteins
* Th1 Cells
* Ubiquitination
|keywords=* D-prostanoid receptor 1
* aging
* hypertension
* lymphocyte
* prostaglandin (PG) D2
|full-text-url=https://sci-hub.do/10.1161/CIRCULATIONAHA.119.042532
}}
{{medline-entry
|title=An Emerging Concern-High Rates of Frailty among Middle-aged and Older Individuals Living with HIV.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31885759


|keywords=* accelerated aging
* anti-retroviral therapy
* frailty
* frailty index
* geriatric syndrome
* human immunodeficiency virus (HIV)
* multimorbidity
* vulnerability
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887139
}}
{{medline-entry
|title=Higher Acuity Resource Utilization With Older Age and Poorer HIV Control in Adolescents and Young Adults in the HIV Research Network.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31904706

|mesh-terms=* Adolescent
* Adult
* Aging
* Anti-Retroviral Agents
* CD4 Lymphocyte Count
* Drug Administration Schedule
* Female
* HIV Infections
* HIV-1
* Humans
* Male
* Medication Adherence
* Viral Load
* Young Adult

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055514
}}
{{medline-entry
|title=Mitochondrial DNA Haplogroups and Frailty in Adults Living with HIV.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31822125


|keywords=* HIV
* aging
* frailty
* haplotypes
* mitochondria
* sarcopenia
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7133433
}}
{{medline-entry
|title=Gallic acid attenuates thymic involution in the d-galactose induced accelerated aging mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31822433


|keywords=* Aging
* FoxN1
* Gallic acid
* Thymus
* d-galactose
|full-text-url=https://sci-hub.do/10.1016/j.imbio.2019.11.005
}}
{{medline-entry
|title=Mitochondrial mass governs the extent of human T cell senescence.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31788930

|mesh-terms=* Adenosine Triphosphate
* Adult
* CD4-Positive T-Lymphocytes
* CD8-Positive T-Lymphocytes
* Cell Movement
* Cell Proliferation
* Cellular Senescence
* Glucose
* Glycolysis
* Humans
* Immunosenescence
* Leukocyte Common Antigens
* Microscopy, Electron, Transmission
* Middle Aged
* Mitochondria
* Rotenone
|keywords=* T cell
* aging
* metabolism
* mitochondria
* senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996952
}}
{{medline-entry
|title=T cells and immune functions of plasma extracellular vesicles are differentially modulated from adults to centenarians.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31785146

|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Extracellular Vesicles
* Female
* Humans
* Immunosenescence
* Lymphocyte Activation
* Male
* Middle Aged
* T-Lymphocytes
|keywords=* T cells
* aging
* centenarians
* extracellular vesicles (EVs)
* immunosenescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914389
}}
{{medline-entry
|title=Defects in Antiviral T Cell Responses Inflicted by Aging-Associated miR-181a Deficiency.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31747595

|mesh-terms=* Aging
* Animals
* CD4-Positive T-Lymphocytes
* CD8-Positive T-Lymphocytes
* Disease Models, Animal
* Lymphocytic Choriomeningitis
* Lymphocytic choriomeningitis virus
* Mice
* MicroRNAs
|keywords=* CD8 effector T cell
* T cell repertoire
* antiviral response
* immune aging
* immunosenescence
* microRNA
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957231
}}
{{medline-entry
|title=Increased Prevalence of Neurocognitive Impairment in Aging People Living With Human Immunodeficiency Virus: The ANRS EP58 HAND 55-70 Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31755936


|keywords=* Frascati criteria
* HAND
* HIV
* aging
* neurocognitive impairment
|full-text-url=https://sci-hub.do/10.1093/cid/ciz670
}}
{{medline-entry
|title=Age-associated changes in human [[CD4]]  T cells point to mitochondrial dysfunction consequent to impaired autophagy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31707363

|mesh-terms=* Adult
* Aged
* CD4-Positive T-Lymphocytes
* Cell Respiration
* Humans
* Immunosenescence
* Longitudinal Studies
* Mitochondria
* Mitophagy
* Young Adult
|keywords=* CD4+ T cells
* aging
* autophagy
* mitochondria
* proteomics
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874450
}}
{{medline-entry
|title=Sex Differences in the Blood Transcriptome Identify Robust Changes in Immune Cell Proportions with Aging and Influenza Infection.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31722210

|mesh-terms=* Aging
* CD4-Positive T-Lymphocytes
* Female
* Humans
* Influenza, Human
* Male
* Monocytes
* Sex Characteristics
* Transcriptome
|keywords=* CD4(+) T cells
* aging
* immune system
* immunology
* influenza
* meta-analysis
* monocytes
* multi-cohort analysis
* sex differences
* transcriptome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6856718
}}
{{medline-entry
|title=Going Beyond Giving Antiretroviral Therapy: Multimorbidity in Older People Aging with HIV in Nigeria.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31711310


|keywords=* ART
* PLWH
* aging
* multimorbidity
* quality of life
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071065
}}
{{medline-entry
|title=Alterations in composition of immune cells and impairment of anti-tumor immune response in aged oral cancer-bearing mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31683168

|mesh-terms=* Aged
* Animals
* Cell Line, Tumor
* Cell Proliferation
* Female
* Humans
* Immunotherapy
* Mice
|keywords=* Aging
* Immune check-point molecules
* Immunosenescence
* Immunotherapy
* Myeloid derived suppressor cells
* Oral cancer
* Regulatory T cells
|full-text-url=https://sci-hub.do/10.1016/j.oraloncology.2019.104462
}}
{{medline-entry
|title=LTA1 is a safe, intranasal enterotoxin-based adjuvant that improves vaccine protection against influenza in young, old and B-cell-depleted (μMT) mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31641151

|mesh-terms=* Adjuvants, Immunologic
* Administration, Intranasal
* Aging
* Animals
* Antibodies
* Antibody Formation
* B-Lymphocytes
* CD4-Positive T-Lymphocytes
* Dose-Response Relationship, Immunologic
* Enterotoxins
* Female
* Immunity, Mucosal
* Immunization
* Inflammation
* Influenza A Virus, H1N1 Subtype
* Lung
* Lymphocyte Activation
* Lymphocyte Depletion
* Mast Cells
* Mice, Inbred C57BL
* Orthomyxoviridae Infections

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805908
}}
{{medline-entry
|title=Thymus Imaging Detection and Size Is Inversely Associated With Metabolic Syndrome and Frailty in People With HIV.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31660382


|keywords=* HIV
* aging
* frailty
* metabolic syndrome
* thymus
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6809752
}}
{{medline-entry
|title=Alterations in peripheral T cell and B cell subsets in patients with osteoarthritis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31624962

|mesh-terms=* Aged
* Aging
* B-Lymphocyte Subsets
* Case-Control Studies
* Female
* Humans
* Male
* Middle Aged
* Osteoarthritis, Knee
* T-Lymphocyte Subsets
|keywords=* B cell
* Lymphocyte
* Osteoarthritis
* T cell
|full-text-url=https://sci-hub.do/10.1007/s10067-019-04768-y
}}
{{medline-entry
|title=Short Communication: Carotid Intima-Media Thickness Is Not Associated with Neurocognitive Impairment Among People Older than 50 Years With and Without HIV Infection from Thailand.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31588776

|mesh-terms=* Aging
* Anti-Retroviral Agents
* Cardiovascular Diseases
* Carotid Intima-Media Thickness
* Cross-Sectional Studies
* Depression
* Female
* HIV Infections
* Humans
* Male
* Middle Aged
* Neurocognitive Disorders
* Quality of Life
* Risk Factors
* Thailand
|keywords=* HIV
* aging
* carotid intima-media thickness
* neurocognitive
|full-text-url=https://sci-hub.do/10.1089/AID.2019.0139
}}
{{medline-entry
|title=Implications of Immune Checkpoint Expression During Aging in HIV-Infected People on Antiretroviral Therapy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31578868

|mesh-terms=* Adult
* Aged
* Aging
* Anti-HIV Agents
* Antiretroviral Therapy, Highly Active
* CD4-Positive T-Lymphocytes
* CD8-Positive T-Lymphocytes
* Cytokines
* Female
* Flow Cytometry
* Gene Expression
* HIV Infections
* HIV-1
* Hepatitis A Virus Cellular Receptor 2
* Humans
* Leukocytes, Mononuclear
* Male
* Middle Aged
* Young Adult
* gag Gene Products, Human Immunodeficiency Virus
|keywords=* aging
* immune checkpoint molecules
* virus suppression
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862963
}}
{{medline-entry
|title=Age-related alterations in human gut [[CD4]] T cell phenotype, T helper cell frequencies, and functional responses to enteric bacteria.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31573727

|mesh-terms=* Adolescent
* Adult
* Age Factors
* Aged
* Aged, 80 and over
* CD4-Positive T-Lymphocytes
* Female
* Gastrointestinal Microbiome
* Humans
* Interleukin-17
* Intestinal Mucosa
* Male
* Middle Aged
* Phenotype
* Th1 Cells
* Th17 Cells
* Young Adult
|keywords=* T helper cells
* aging
* gut
* human
|full-text-url=https://sci-hub.do/10.1002/JLB.5A0919-177RR
}}
{{medline-entry
|title=Determinants of blood telomere length in antiretroviral treatment-naïve HIV-positive participants enrolled in the NEAT 001/ANRS 143 clinical trial.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31532902

|mesh-terms=* Adult
* Aged
* Anti-Retroviral Agents
* Cross-Sectional Studies
* Darunavir
* Emtricitabine
* Female
* HIV Infections
* Humans
* Logistic Models
* Male
* Middle Aged
* RNA, Viral
* Raltegravir Potassium
* Ritonavir
* Telomere
* Tenofovir
|keywords=* HIV infection
* aging
* immunosenescence
* telomere length
* viral load
|full-text-url=https://sci-hub.do/10.1111/hiv.12791
}}
{{medline-entry
|title=Human T Cell Differentiation Negatively Regulates Telomerase Expression Resulting in Reduced Activation-Induced Proliferation and Survival.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31497023

|mesh-terms=* Adult
* Cell Differentiation
* Cell Proliferation
* Cell Survival
* Humans
* T-Lymphocytes
* Telomerase
|keywords=* T cell subsets
* T lymphocytes
* aging
* alternative splicing
* differentiation
* hTERT
* proliferation
* telomerase
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712505
}}
{{medline-entry
|title=Short Communication: Getting Older with HIV: Increasing Frequency of Comorbidities and Polypharmacy in Brazilian HIV Patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31452382

|mesh-terms=* Aged
* Aging
* Brazil
* CD4 Lymphocyte Count
* Cardiovascular Diseases
* Comorbidity
* Diabetes Mellitus
* Female
* HIV Infections
* Humans
* Life Expectancy
* Male
* Middle Aged
* Neoplasms
* Polypharmacy
|keywords=* Brazil
* HIV
* aging
* noncommunicable diseases
|full-text-url=https://sci-hub.do/10.1089/AID.2019.0069
}}
{{medline-entry
|title=Gait Speed Decline Is Associated with Hemoglobin A1C, Neurocognitive Impairment, and Black Race in Persons with HIV.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31468979

|mesh-terms=* Adult
* African Americans
* Aging
* CD4 Lymphocyte Count
* Cohort Studies
* Female
* Glycated Hemoglobin A
* HIV Infections
* Humans
* Longitudinal Studies
* Male
* Middle Aged
* Neurocognitive Disorders
* Odds Ratio
* RNA, Viral
* Risk Factors
* Walking Speed
|keywords=* aging
* gait speed
* hemoglobin A1C
* neurocognitive impairment
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862955
}}
{{medline-entry
|title=Noncommunicable Diseases Burden and Risk Factors in a Cohort of HIV+ Elderly Patients in Malawi.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31468993

|mesh-terms=* Adult
* Age Factors
* Aged
* Anti-HIV Agents
* Anti-Retroviral Agents
* CD4 Lymphocyte Count
* Comorbidity
* Cost of Illness
* Cross-Sectional Studies
* Diabetes Mellitus
* Female
* HIV Infections
* Humans
* Hypertension
* Malawi
* Male
* Middle Aged
* Noncommunicable Diseases
* Odds Ratio
* Prevalence
* Retrospective Studies
* Risk Factors
|keywords=* HIV infection
* Malawi
* aging
* noncommunicable diseases
|full-text-url=https://sci-hub.do/10.1089/AID.2019.0125
}}
{{medline-entry
|title=Aging promotes reorganization of the [[CD4]] T cell landscape toward extreme regulatory and effector phenotypes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31457092

|mesh-terms=* Aging
* Animals
* CD4-Positive T-Lymphocytes
* High-Throughput Nucleotide Sequencing
* Immunomodulation
* Mice
* Phenotype
* Sequence Analysis, RNA
* Single-Cell Analysis
* T-Lymphocyte Subsets

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703865
}}
{{medline-entry
|title=Prevalence of hypertension and cardiovascular risk factors among long-term AIDS survivors: A report from the field.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31448551

|mesh-terms=* Acquired Immunodeficiency Syndrome
* Adult
* Anti-Retroviral Agents
* CD4 Lymphocyte Count
* Cardiovascular Diseases
* Diabetes Mellitus
* Diagnostic Screening Programs
* Female
* HIV Infections
* HIV-1
* Haiti
* Humans
* Hypercholesterolemia
* Hypertension
* Male
* Middle Aged
* Obesity
* Prevalence
* Retrospective Studies
* Risk Factors
* Smoking
* Survivors
|keywords=* HIV
* aging
* cardiovascular disease
* hypertension
* risk assessment
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896990
}}