Редактирование: Aging genes 30-39 (раздел)

==BACE1==

* {{medline-title
|title=Electric Stimulation of Neurogenesis Improves Behavioral Recovery After Focal Ischemia in Aged Rats.
|date=2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32742258
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365235
}}
* {{medline-title
|title=Dendrobium nobile Lindl. Alkaloids Ameliorate Cognitive Dysfunction in Senescence Accelerated SAMP8 Mice by Decreasing Amyloid-β Aggregation and Enhancing Autophagy Activity.
|date=2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32538851
|full-text-url=https://sci-hub.do/10.3233/JAD-200308
}}
* {{medline-title
|title=Disruption of synaptic expression pattern and age-related DNA oxidation in a neuronal model of lead-induced toxicity.
|date=05.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32058320
|full-text-url=https://sci-hub.do/10.1016/j.etap.2020.103350
}}
* {{medline-title
|title=Age- and sex-dependent profiles of [[APP]] fragments and key secretases align with changes in despair-like behavior and cognition in young [[APP]]Swe/Ind mice.
|date=02.04.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30803762
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2019.02.083
}}
* {{medline-title
|title=Selective reduction of [[APP]]-[[BACE1]] activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PD[[APP]] mice.
|date=03.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30572184
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357873
}}
* {{medline-title
|title=Temporal Effects of Neuron-specific beta-secretase 1 ([[BACE1]]) Knock-in on the Mouse Brain Metabolome: Implications for Alzheimer's Disease.
|date=15.01.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30496823
|full-text-url=https://sci-hub.do/10.1016/j.neuroscience.2018.11.031
}}
* {{medline-title
|title=Removal of p75 Neurotrophin Receptor Expression from Cholinergic Basal Forebrain Neurons Reduces Amyloid-β Plaque Deposition and Cognitive Impairment in Aged APP/PS1 Mice.
|date=07.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30374941
|full-text-url=https://sci-hub.do/10.1007/s12035-018-1404-2
}}
* {{medline-title
|title=Axonal organization defects in the hippocampus of adult conditional [[BACE1]] knockout mice.
|date=19.09.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30232227
|full-text-url=https://sci-hub.do/10.1126/scitranslmed.aao5620
}}
* {{medline-title
|title=Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease.
|date=10.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29981845
|full-text-url=https://sci-hub.do/10.1016/j.bbadis.2018.07.005
}}
* {{medline-title
|title=Effects of senescence and angiotensin II on expression and processing of amyloid precursor protein in human cerebral microvascular endothelial cells.
|date=15.01.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29348391
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811245
}}
* {{medline-title
|title=Neuroprotective potential of high-dose biotin.
|date=11.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29150274
|full-text-url=https://sci-hub.do/10.1016/j.mehy.2017.10.012
}}
* {{medline-title
|title=The pathological roles of [[NDRG2]] in Alzheimer's disease, a study using animal models and APPwt-overexpressed cells.
|date=08.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28670853
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492714
}}
* {{medline-title
|title=Ferulic Acid Suppresses Amyloid [i]β[/i] Production in the Human Lens Epithelial Cell Stimulated with Hydrogen Peroxide.
|date=2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28409157
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376927
}}
* {{medline-title
|title=Vitamin D Combined with Resveratrol Prevents Cognitive Decline in SAMP8 Mice.
|date=2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28176624
|full-text-url=https://sci-hub.do/10.2174/1567205014666170207093455
}}
* {{medline-title
|title=Prevention of tau increase in cerebrospinal fluid of [[APP]] transgenic mice suggests downstream effect of [[BACE1]] inhibition.
|date=06.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27750032
|full-text-url=https://sci-hub.do/10.1016/j.jalz.2016.09.005
}}
* {{medline-title
|title=Fuzhisan Ameliorates the Memory Deficits in Aged SAMP8 Mice via Decreasing Aβ Production and Tau Hyperphosphorylation of the Hippocampus.
|date=11.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27518086
|full-text-url=https://sci-hub.do/10.1007/s11064-016-2028-4
}}
* {{medline-title
|title=Behaviour and cognitive changes correlated with hippocampal neuroinflammaging and neuronal markers in female SAMP8, a model of accelerated senescence.
|date=07.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27094468
|full-text-url=https://sci-hub.do/10.1016/j.exger.2016.03.014
}}
* {{medline-title
|title=Partial [[BACE1]] reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of [[APP]]-CTF.
|date=03.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26923405
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773919
}}
* {{medline-title
|title=miR-186 is decreased in aged brain and suppresses [[BACE1]] expression.
|date=05.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26710318
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837067
}}
* {{medline-title
|title=IL-17A is implicated in lipopolysaccharide-induced neuroinflammation and cognitive impairment in aged rats via microglial activation.
|date=15.09.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26373740
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572693
}}
* {{medline-title
|title=Functions of miR-9 and miR-9* during Aging in SAMP8 Mice and Their Possible Mechanisms.
|date=06.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26149132
|full-text-url=https://sci-hub.do/10.3881/j.issn.1000-503X.2015.03.001
}}
* {{medline-title
|title=[[SNX15]] Regulates Cell Surface Recycling of [[APP]] and Aβ Generation.
|date=08.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26115702
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691577
}}
* {{medline-title
|title=Non-neuronal and neuronal [[BACE1]] elevation in association with angiopathic and leptomeningeal β-amyloid deposition in the human brain.
|date=02.05.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25934480
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428107
}}
* {{medline-title
|title=The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice.
|date=06.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25666032
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387064
}}
* {{medline-title
|title=Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer's disease mouse model.
|date=13.09.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25213836
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172865
}}
* {{medline-title
|title=Development and characterization of an aged onset model of Alzheimer's disease in Drosophila melanogaster.
|date=11.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25173219
|full-text-url=https://sci-hub.do/10.1016/j.expneurol.2014.08.021
}}
* {{medline-title
|title=Sildenafil Decreases [[BACE1]] and Cathepsin B Levels and Reduces APP Amyloidogenic Processing in the SAMP8 Mouse.
|date=06.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25063079
|full-text-url=https://sci-hub.do/10.1093/gerona/glu106
}}
* {{medline-title
|title=Oxidized LDL lipids increase β-amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation.
|date=10.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25048970
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180009
}}
* {{medline-title
|title=Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the [[APP]]/Ld transgenic mouse model of Alzheimer's disease.
|date=02.05.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24885175
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028006
}}
* {{medline-title
|title=Lessons from a [[BACE1]] inhibitor trial: off-site but not off base.
|date=10.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24530026
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205206
}}
* {{medline-title
|title=Expression of amyloid-associated miRNAs in both the forebrain cortex and hippocampus of middle-aged rat.
|date=2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24401368
|full-text-url=https://sci-hub.do/10.1159/000356646
}}
* {{medline-title
|title=MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 ([[BACE1]]) in human primary brain cultures and is reduced in brain tissue specimens of Alzheimer disease subjects.
|date=21.02.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24352696
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931075
}}
* {{medline-title
|title=Rheb GTPase regulates β-secretase levels and amyloid β generation.
|date=28.02.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24368770
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937651
}}
* {{medline-title
|title=Can [[BACE1]] inhibition mitigate early axonal pathology in neurological diseases?
|date=2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24081378
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995167
}}
* {{medline-title
|title=Stress contributes to the development of central insulin resistance during aging: implications for Alzheimer's disease.
|date=12.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24090692
|full-text-url=https://sci-hub.do/10.1016/j.bbadis.2013.09.013
}}
* {{medline-title
|title=[Effect of PNS on the activity and content of [[BACE1]] in the brain of SAMP8 mice with Alzheimer's disease].
|date=07.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24063218

}}