Редактирование: Aging genes 30-39 (раздел)

==CDK4==

* {{medline-title
|title=Emerging Roles for the [i]INK4a/ARF[/i] ([i]CDKN2A[/i]) Locus in Adipose Tissue: Implications for Obesity and Type 2 Diabetes.
|date=22.09.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32971832
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7563355
}}
* {{medline-title
|title=Guilu Erxian Glue () Inhibits Chemotherapy-Induced Bone Marrow Hematopoietic Stem Cell Senescence in Mice May via p16 -Rb Signaling Pathway.
|date=11.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32915425
|full-text-url=https://sci-hub.do/10.1007/s11655-020-3098-3
}}
* {{medline-title
|title=Hepatoprotective effects of hydroxysafflor yellow A in D-galactose-treated aging mice.
|date=15.08.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32454116
|full-text-url=https://sci-hub.do/10.1016/j.ejphar.2020.173214
}}
* {{medline-title
|title=Astragaloside IV ameliorates radiation-induced senescence via antioxidative mechanism.
|date=08.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32412100
|full-text-url=https://sci-hub.do/10.1111/jphp.13284
}}
* {{medline-title
|title=Expression of p16 in nodular fasciitis: an implication for self-limited and inflammatory nature of the lesion.
|date=2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31933915
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945175
}}
* {{medline-title
|title=Anti-cell growth and anti-cancer stem cell activity of the [[CDK4]]/6 inhibitor palbociclib in breast cancer cells.
|date=05.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31823286
|full-text-url=https://sci-hub.do/10.1007/s12282-019-01035-5
}}
* {{medline-title
|title=Compromising the constitutive p16  expression sensitizes human neuroblastoma cells to Hsp90 inhibition and promotes premature senescence.
|date=04.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31692039
|full-text-url=https://sci-hub.do/10.1002/jcb.29493
}}
* {{medline-title
|title=Induction of Senescence in Cancer Cells by a Novel Combination of Cucurbitacin B and Withanone: Molecular Mechanism and Therapeutic Potential.
|date=22.05.2020
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31112603
|full-text-url=https://sci-hub.do/10.1093/gerona/glz077
}}
* {{medline-title
|title=Ribosomal protein RPL22/eL22 regulates the cell cycle by acting as an inhibitor of the [[CDK4]]-cyclin D complex.
|date=03-04.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30874462
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464582
}}
* {{medline-title
|title=p16  deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence.
|date=09.2019
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30811968
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6708504
}}
* {{medline-title
|title=Efficient immortalization of cells derived from critically endangered Tsushima leopard cat (Prionailurus bengalensis euptilurus) with expression of mutant [[CDK4]], Cyclin D1, and telomerase reverse transcriptase.
|date=12.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30225752
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269356
}}
* {{medline-title
|title=Effects of Fibronectin 1 on Cell Proliferation, Senescence and Apoptosis of Human Glioma Cells Through the PI3K/AKT Signaling Pathway.
|date=2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30048971
|full-text-url=https://sci-hub.do/10.1159/000492096
}}
* {{medline-title
|title=Cyclin D1 depletion interferes with oxidative balance and promotes cancer cell senescence.
|date=25.06.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29880532
|full-text-url=https://sci-hub.do/10.1242/jcs.214726
}}
* {{medline-title
|title=Fucoidan Rescues p-Cresol-Induced Cellular Senescence in Mesenchymal Stem Cells via FAK-Akt-TWIST Axis.
|date=06.04.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29642406
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923408
}}
* {{medline-title
|title=Carvacrol nanoemulsion evokes cell cycle arrest, apoptosis induction and autophagy inhibition in doxorubicin resistant-A549 cell line.
|date=2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29405784
|full-text-url=https://sci-hub.do/10.1080/21691401.2018.1434187
}}
* {{medline-title
|title=Mechanistic understanding of the role of [[ATRX]] in senescence provides new insight for combinatorial therapies with [[CDK4]] inhibitors.
|date=2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29404388
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791849
}}
* {{medline-title
|title=Glutaredoxin-1 Silencing Induces Cell Senescence via p53/p21/p16 Signaling Axis.
|date=02.03.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29356545
|full-text-url=https://sci-hub.do/10.1021/acs.jproteome.7b00761
}}
* {{medline-title
|title=Inhibition of [[CIP2A]] attenuates tumor progression by inducing cell cycle arrest and promoting cellular senescence in hepatocellular carcinoma.
|date=08.01.2018
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29175329
|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2017.11.124
}}
* {{medline-title
|title=Preclinical characterization of abemaciclib in hormone receptor positive breast cancer.
|date=19.09.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29050219
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642494
}}
* {{medline-title
|title=Immortalized prairie vole-derived fibroblasts (VMF-K4DTs) can be transformed into pluripotent stem cells and provide a useful tool with which to determine optimal reprogramming conditions.
|date=21.06.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28331164
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481634
}}
* {{medline-title
|title=Molecular mechanism of G  arrest and cellular senescence induced by LEE011, a novel [[CDK4]]/CDK6 inhibitor, in leukemia cells.
|date=2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28286417
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340031
}}
* {{medline-title
|title=p16 loss rescues functional decline of Brca1-deficient mammary stem cells.
|date=18.04.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28278054
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405722
}}
* {{medline-title
|title=p16  enhances the transcriptional and the apoptotic functions of p53 through DNA-dependent interaction.
|date=07.2017
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28218424
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266037
}}
* {{medline-title
|title=p16INK4a suppresses [[BRCA1]]-deficient mammary tumorigenesis.
|date=20.12.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27811360
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356676
}}
* {{medline-title
|title=A steroid like phytochemical Antcin M is an anti-aging reagent that eliminates hyperglycemia-accelerated premature senescence in dermal fibroblasts by direct activation of Nrf2 and SIRT-1.
|date=27.09.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27542238
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325331
}}
* {{medline-title
|title=[[CDK4]]-[[CDK6]] inhibitors induce autophagy-mediated degradation of [[DNMT1]] and facilitate the senescence antitumor response.
|date=02.10.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27532423
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079664
}}
* {{medline-title
|title=Sperm-associated antigen 9 ([[SPAG9]]) promotes the survival and tumor growth of triple-negative breast cancer cells.
|date=10.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27449044
|full-text-url=https://sci-hub.do/10.1007/s13277-016-5240-6
}}
* {{medline-title
|title=Double staining of β-galactosidase with fibrosis and cancer markers reveals the chronological appearance of senescence in liver carcinogenesis induced by diethylnitrosamine.
|date=22.01.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26589970
|full-text-url=https://sci-hub.do/10.1016/j.toxlet.2015.11.011
}}
* {{medline-title
|title=Efficacy of [[CDK4]] inhibition against sarcomas depends on their levels of [[CDK4]] and p16ink4 mRNA.
|date=01.12.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26528855
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747352
}}
* {{medline-title
|title=Suppression of [[RAD21]] Induces Senescence of MDA-[[MB]]-231 Human Breast Cancer Cells Through [[RB1]] Pathway Activation Via c-Myc Downregulation.
|date=06.2016
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26529363
|full-text-url=https://sci-hub.do/10.1002/jcb.25426
}}
* {{medline-title
|title=Molecular differences between stromal cell populations from deciduous and permanent human teeth.
|date=18.04.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25927523
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417277
}}
* {{medline-title
|title=Functional Effect of Pim1 Depends upon Intracellular Localization in Human Cardiac Progenitor Cells.
|date=29.05.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25882843
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447967
}}
* {{medline-title
|title=[[MDM2]] turnover and expression of [[ATRX]] determine the choice between quiescence and senescence in response to [[CDK4]] inhibition.
|date=10.04.2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25803170
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480747
}}
* {{medline-title
|title=Evidence for a [[CDK4]]-dependent checkpoint in a conditional model of cellular senescence.
|date=2015
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25695870
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613988
}}
* {{medline-title
|title=MiR-506 suppresses proliferation and induces senescence by directly targeting the [[CDK4]]/6-[[FOXM1]] axis in ovarian cancer.
|date=07.2014
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24604117
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144705
}}
* {{medline-title
|title=Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes.
|date=15.08.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23707792
|full-text-url=https://sci-hub.do/10.1016/j.mce.2013.05.003
}}
* {{medline-title
|title=Oxidized low-density lipoprotein induces hematopoietic stem cell senescence.
|date=09.2013
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23620010
|full-text-url=https://sci-hub.do/10.1002/cbin.10121
}}