Редактирование: UGT2A1 (раздел)

==Publications==

{{medline-entry
|title=Glucuronidation of odorant molecules in the rat olfactory system: activity, expression and age-linked modifications of UDP-glucuronosyltransferase isoforms, [[UGT1A6]] and [[UGT2A1]], and relation to mitral cell activity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/12425948
|abstract=The aim of the present study was to examine the glucuronidation of a series of odorant molecules by homogenates prepared either with rat olfactory mucosa, olfactory bulb or brain. Most of the odorant molecules tested were efficiently conjugated by olfactory mucosa, whereas olfactory bulb and brain homogenates displayed lower activities and glucuronidated only a few molecules. Important age-related changes in glucuronidation efficiency were observed in olfactory mucosa and bulb. Therefore, we studied changes in expression of two UDP-glucuronosyltransferase isoforms, [[UGT1A6]] and [[UGT2A1]], in 1-day, 1- and 2-week-, 3-, 12- and 24-month-old rats. [[UGT1A6]] was expressed at the same transcriptional level in the olfactory mucosa, bulb and brain, throughout the life period studied. [[UGT2A1]] mRNA was expressed in both olfactory mucosa and olfactory bulb, in accordance with previous results [Mol. Brain Res. 90 (2001) 83], but [[UGT2A1]] transcriptional level was 400-4000 times higher than that of [[UGT1A6]]. Moreover, age-dependent variations in [[UGT2A1]] mRNA expression were observed. As it has been suggested that drug metabolizing enzymes could participate in olfactory function, mitral cell electrical activity was recorded during exposure to different odorant molecules in young, adult and old animals. Age-related changes in the amplitude of response after stimulation with several odorant molecules were observed, and the highest responses were obtained with molecules that were not efficiently glucuronidated by olfactory mucosa. In conclusion, the present work presents new evidence of the involvement of UGT activity in some steps of the olfactory process.
|mesh-terms=* Action Potentials
* Aging
* Animals
* Animals, Newborn
* Cerebral Cortex
* Gene Expression Regulation, Enzymologic
* Glucuronosyltransferase
* Male
* Monosaccharide Transport Proteins
* Neurons
* Odorants
* Olfactory Bulb
* Olfactory Pathways
* Olfactory Receptor Neurons
* Protein Isoforms
* Rats
* Rats, Wistar
* Receptors, Odorant
* Smell
* Telencephalon
* Uridine Diphosphate Glucuronic Acid

|full-text-url=https://sci-hub.do/10.1016/s0169-328x(02)00455-2
}}