Редактирование: UGT1A9 (раздел)

==Publications==

{{medline-entry
|title=[[UGT1A9]] -275T>A/-2152C>T polymorphisms correlate with low MPA exposure and acute rejection in MMF/tacrolimus-treated kidney transplant patients.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/19494809
|abstract=Mycophenolate mofetil (MMF) is an immunosuppressive drug commonly used in the context of kidney transplantation. Exposure to the active metabolite mycophenolic acid (MPA) is associated with risk of allograft rejection. MPA pharmacokinetics varies between individuals, the potential cause being the presence of genetic polymorphisms in key enzymes. We genotyped 338 kidney transplant patients for [[UGT1A8]], [[UGT1A9]], [[UGT2B7]], and MRP2 polymorphisms and recorded MPA exposure and biopsy-proven acute rejections (BPARs) during a 1-year follow-up. Tacrolimus-treated patients who were [[UGT1A9]] -275T>A and/or -2152C>T carriers displayed a 20% lower MPA area under the concentration-time curve from 0 to 12 h (AUC(0-12)) (P = 0.012). [[UGT1A9]]*3 carriers displayed a 49% higher MPA AUC(0-12) when treated with tacrolimus and a 54% higher MPA AUC(0-12) when treated with cyclosporine (P < 0.005). Cyclosporine-treated [[UGT1A8]]*2/*2 (518GG) patients had an 18% higher MPA AUC(0-12) compared with noncarriers. Carrying the [[UGT1A9]] -275T>A and/or -2152C>T polymorphism significantly predicted acute rejection in fixed-dose (FD) MMF-treated patients receiving tacrolimus (odds ratio 13.3, 95% confidence interval 1.1-162.3; P < 0.05). [[UGT1A9]] -275T>A and/or -2152C>T genotyping may identify patients at risk of MPA underexposure and acute rejection when receiving treatment with MMF and tacrolimus.
|mesh-terms=* Adolescent
* Adult
* Aged
* Aging
* Antibiotics, Antineoplastic
* Area Under Curve
* Calcineurin Inhibitors
* Creatinine
* Female
* Glucuronosyltransferase
* Graft Rejection
* Humans
* Immunosuppressive Agents
* Kidney Transplantation
* Male
* Middle Aged
* Multidrug Resistance-Associated Proteins
* Mycophenolic Acid
* Polymorphism, Genetic
* Prospective Studies
* Sex Characteristics
* Tacrolimus
* Treatment Outcome
* Young Adult

|full-text-url=https://sci-hub.do/10.1038/clpt.2009.83
}}