Редактирование: UGT1A7 (раздел)

==Publications==

{{medline-entry
|title=Microsomal quercetin glucuronidation in rat small intestine depends on age and segment.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21543555
|abstract=UDP-glucuronosyltransferase (UGT) activity toward the flavonoid quercetin and UGT protein were characterized in three equidistant small intestine ([[SI]]) segments from 4-, 12-, 18-, and 28-month-old male Fischer 344 rats (n = 8/age) using villin to control for enterocyte content. [[SI]] microsomal intrinsic clearance of quercetin was increased 3- to 9-fold from 4 months in the proximal and distal [[SI]] at 12 and 18 months. Likewise, at 30 μM quercetin, [[SI]] microsomal glucuronidation activity was increased with age: 4.8- and 3.9-fold greater at 18 months than at 4 months. Quercetin UGT regioselectivity was not changed by age. The distal [[SI]] preferentially catalyzed glucuronidation at the 7-position, whereas the proximal [[SI]] produced the greatest proportion of 4'- and 3'-conjugates. Enterocyte UGT content in different [[SI]] segments was not consistently changed with age. In the proximal [[SI]], UGT1A increased 64 and 150% at 12 and 18 months and [[UGT1A1]], [[UGT1A7]], and [[UGT1A8]] were also increased at 12 and 18 months. However, age-related changes in expression were inconsistent in the medial and distal segments. Microsomal rates of quercetin glucuronidation and UGT expression were positively correlated with [[UGT1A1]] content for all pooled samples (r = 0.467) and at each age (r = 0.538-0.598). [[UGT1A7]] was positively correlated with total, 7-O- and 3-O-quercetin glucuronidation at 18 months. Thus, age-related differences in UGT quercetin glucuronidation depend on intestinal segment, are more pronounced in the proximal and distal segments and may be partially related to [[UGT1A1]] and [[UGT1A7]] content.
|mesh-terms=* Aging
* Animals
* Blotting, Western
* Chromatography, High Pressure Liquid
* Dose-Response Relationship, Drug
* Enterocytes
* Glucuronides
* Glucuronosyltransferase
* Intestinal Mucosa
* Intestine, Small
* Male
* Microsomes
* Quercetin
* Rats
* Rats, Inbred F344

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141883
}}