Редактирование: TMEM135 (раздел)

==Publications==

{{medline-entry
|title=Mouse [i]Tmem135[/i] mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27863209
|abstract=While the aging process is central to the pathogenesis of age-dependent diseases, it is poorly understood at the molecular level. We identified a mouse mutant with accelerated aging in the retina as well as pathologies observed in age-dependent retinal diseases, suggesting that the responsible gene regulates retinal aging, and its impairment results in age-dependent disease. We determined that a mutation in the transmembrane 135 ([i]Tmem135[/i]) is responsible for these phenotypes. We observed localization of [[TMEM135]] on mitochondria, and imbalance of mitochondrial fission and fusion in mutant [i]Tmem135[/i] as well as [i]Tmem135[/i] overexpressing cells, indicating that [[TMEM135]] is involved in the regulation of mitochondrial dynamics. Additionally, mutant retina showed higher sensitivity to oxidative stress. These results suggest that the regulation of mitochondrial dynamics through [[TMEM135]] is critical for protection from environmental stress and controlling the progression of retinal aging. Our study identified [[TMEM135]] as a critical link between aging and age-dependent diseases.
|mesh-terms=* Adaptor Proteins, Signal Transducing
* Aging
* Animals
* Mice
* Mitochondria
* Mitochondrial Dynamics
* Mutant Proteins
* Nuclear Proteins
* Retinal Diseases
|keywords=* ENU
* age-dependent retinal diseases
* aging
* cell biology
* mitochondrial dynamics
* mouse
* neuroscience
* retina
* retinal pigment epithelium
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117855
}}