Редактирование: TFEC (раздел)

==Publications==

{{medline-entry
|title=Induction of FGF-7 after kidney damage: a possible paracrine mechanism for tubule repair.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/8945990
|abstract=A member of the fibroblast growth factor (FGF) family, keratinocyte growth factor (FGF-7 has unique specificity for epithelial cells. We investigated the role of FGF-7 in repair of proximal tubular damage caused by S-(1,1,2,2-tetrafluoroethyl)-L-cysteine ([[TFEC]]). In situ hybridization localized FGF-7 to interstitial cells in the medulla and outer stripe of the outer medulla. Interstitial FGF-7 expression increased throughout the kidney 1 day after [[TFEC]] treatment. [[FGFR2]] IIIb mRNA was high in the papilla and medulla and also increased after [[TFEC]] administration. By in situ hybridization, [[FGFR2]] IIIb was localized to the tubular epithelium, particularly in collecting ducts. Proliferation of collecting duct epithelial cells increased in adult kidney after damage to the proximal tubule. [[FGFR2]] IIIb, but not FGF-7, mRNA was also expressed by rat proximal tubule epithelial (RPTE) cells in vitro, and FGF-7 increased DNA synthesis in RPTE. Thus [[FGFR2]] IIIb and FGF-7 expression is segregated between epithelial and interstitial cells forming a paracrine growth factor loop. These results raise the possibility that a novel paracrine growth loop is activated by chemical damage and regulates epithelial cell growth during tubular repair.
|mesh-terms=* Aging
* Animals
* Animals, Newborn
* Cell Division
* Cells, Cultured
* Epithelial Cells
* Epithelium
* Fibroblast Growth Factor 10
* Fibroblast Growth Factor 7
* Fibroblast Growth Factors
* Gene Expression Regulation
* Growth Substances
* Kidney
* Kidney Tubules, Proximal
* Male
* RNA, Messenger
* Rats
* Rats, Inbred F344
* Receptors, Fibroblast Growth Factor
* Tissue Distribution
* Wound Healing

|full-text-url=https://sci-hub.do/10.1152/ajprenal.1996.271.5.F967
}}