Редактирование: TEAD2 (раздел)

==Publications==

{{medline-entry
|title=Novel transcriptional targets of the [[SRY]]-HMG box transcription factor [[SOX4]] link its expression to the development of small cell lung cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22084397
|abstract=The HMG box transcription factor [[SOX4]] involved in neuronal development is amplified and overexpressed in a subset of lung cancers, suggesting that it may be a driver oncogene. In this study, we sought to develop this hypothesis including by defining targets of [[SOX4]] that may mediate its involvement in lung cancer. Ablating [[SOX4]] expression in [[SOX4]]-amplified lung cancer cells revealed a gene expression signature that included genes involved in neuronal development such as PCDHB, [[MYB]], [[RBP1]], and [[TEAD2]]. Direct recruitment of [[SOX4]] to gene promoters was associated with their upregulation upon ectopic overexpression of [[SOX4]]. We confirmed upregulation of the [[SOX4]] expression signature in a panel of primary lung tumors, validating their specific response by a comparison using embryonic fibroblasts from Sox4-deficient mice. Interestingly, we found that small cell lung cancer (SCLC), a subtype of lung cancer with neuroendocrine characteristics, was generally characterized by high levels of [[SOX2]], [[SOX4]], and [[SOX11]] along with the [[SOX4]]-specific gene expression signature identified. Taken together, our findings identify a functional role for SOX genes in SCLC, particularly for [[SOX4]] and several novel targets defined in this study.
|mesh-terms=* Aging
* Animals
* Blotting, Western
* Carcinoma, Small Cell
* Cell Line, Tumor
* Chromatin Immunoprecipitation
* Gene Expression
* Humans
* Lung Neoplasms
* Mice
* Promoter Regions, Genetic
* Real-Time Polymerase Chain Reaction
* SOXC Transcription Factors
* Transcription, Genetic

|full-text-url=https://sci-hub.do/10.1158/0008-5472.CAN-11-3506
}}