Редактирование: TCF7L1 (раздел)

==Publications==

{{medline-entry
|title=[[TCF7L1]] promotes skin tumorigenesis independently of β-catenin through induction of [[LCN2]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28467300
|abstract=The transcription factor [i][[TCF7L1]][/i] is an embryonic stem cell signature gene that is upregulated in multiple aggressive cancer types, but its role in skin tumorigenesis has not yet been defined. Here we document [[TCF7L1]] upregulation in skin squamous cell carcinoma (SCC) and demonstrate that [[TCF7L1]] overexpression increases tumor incidence, tumor multiplicity, and malignant progression in the chemically induced mouse model of skin SCC. Additionally, we show that downregulation of [[TCF7L1]] and its paralogue [[TCF7L2]] reduces tumor growth in a xenograft model of human skin SCC. Using separation-of-function mutants, we show that [[TCF7L1]] promotes tumor growth, enhances cell migration, and overrides oncogenic RAS-induced senescence independently of its interaction with β-catenin. Through transcriptome profiling and combined gain- and loss-of-function studies, we identified [[LCN2]] as a major downstream effector of [[TCF7L1]] that drives tumor growth. Our findings establish a tumor-promoting role for [[TCF7L1]] in skin and elucidate the mechanisms underlying its tumorigenic capacity.
|mesh-terms=* Animals
* Carcinogenesis
* Carcinoma, Squamous Cell
* Disease Models, Animal
* Gene Expression Profiling
* Heterografts
* Humans
* Lipocalin-2
* Mice
* Skin Neoplasms
* Transcription Factor 7-Like 1 Protein
* beta Catenin
|keywords=* TCF7L1
* cancer biology
* cell biology
* cell migration
* human
* mouse
* oncogene-induced senescence
* skin squamous cell carcinoma
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438253
}}