Редактирование: TAF7 (раздел)

==Publications==

{{medline-entry
|title=Basonuclin 1 deficiency causes testicular premature aging: [[BNC1]] cooperates with [[TAF7]]L to regulate spermatogenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31065688
|abstract=Basonuclin ([[BNC1]]) is expressed primarily in proliferative keratinocytes and gametogenic cells. However, its roles in spermatogenesis and testicular aging were not clear. Previously we discovered a heterozygous [[BNC1]] truncation mutation in a premature ovarian insufficiency pedigree. In this study, we found that male mice carrying the truncation mutation exhibited progressively fertility loss and testicular premature aging. Genome-wide expression profiling and direct binding studies (by chromatin immunoprecipitation sequencing) with [[BNC1]] in mouse testis identified several spermatogenesis-specific gene promoters targeted by [[BNC1]] including kelch-like family member 10 (Klhl10), testis expressed 14 (Tex14), and spermatogenesis and centriole associated 1 (Spatc1). Moreover, biochemical analysis showed that [[BNC1]] was associated with TATA-box binding protein-associated factor 7 like ([[TAF7]]L), a germ cell-specific paralogue of the transcription factor IID subunit [[TAF7]], both in vitro and in testis, suggesting that [[BNC1]] might directly cooperate with [[TAF7]]L to regulate spermatogenesis. The truncation mutation disabled nuclear translocation of the [[BNC1]]/[[TAF7]]L complex, thus, disturbing expression of related genes and leading to testicular premature aging. Similarly, expressions of [[BNC1]], [[TAF7]]L, Y-box-binding protein 2 (YBX2), outer dense fiber of sperm tails 1 (ODF1), and glyceraldehyde-3-phosphate dehydrogenase, spermatogenic (GAPDHS) were significantly decreased in the testis of men with non-obstructive azoospermia. The present study adds to the understanding of the physiology of male reproductive aging and the mechanism of spermatogenic failure in infertile men.

|keywords=* BNC1
* TAF7L
* gene mutation
* spermatogenesis
* testicular aging
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052986
}}