Редактирование: TAF1 (раздел)

==Publications==

{{medline-entry
|title=Sustained expression of a neuron-specific isoform of the Taf1 gene in development stages and aging in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22842574
|abstract=TATA-box binding protein associated factor 1 ([[TAF1]]) protein is the largest and the essential component of the TFIID complex in the pathway of RNA polymerase II-mediated gene transcription, and it regulates transcription of a large number of genes related to cell division. The neuron-specific isoform of the [[TAF1]] gene (N-[[TAF1]]), which we reported previously, may have an essential role in neurons through transcriptional regulation of many neuron-specific genes. In the present study, we cloned the full-length cDNA that encodes the mouse homologue of N-[[TAF1]] (N-Taf1) protein. By carrying out of real time RT-PCR, we investigated the expression analysis of the N-Taf1 mRNA in mouse tissues and cell lines. As well as the human N-[[TAF1]], the N-Taf1 showed limited expression in the brain and neuroblastoma, whereas Taf1 expressed elsewhere. Furthermore, in mouse embryo head or mouse brain, mRNA expression of [[TAF1]] changes dramatically during development but N-Taf1 showed sustained expression. Our result suggests that the N-Taf1 gene has an important role in non-dividing neuronal cell rather than in cell division and proliferation during neurogenesis.
|mesh-terms=* Aging
* Animals
* Base Sequence
* Brain
* Cell Division
* Cell Line, Tumor
* Cell Proliferation
* Cloning, Molecular
* Embryo, Mammalian
* Exons
* Gene Expression Regulation, Developmental
* Head
* Histone Acetyltransferases
* Humans
* Mice
* Mice, Inbred BALB C
* Molecular Sequence Data
* Neurogenesis
* Neurons
* Open Reading Frames
* Protein Isoforms
* RNA, Messenger
* TATA-Binding Protein Associated Factors
* Transcription Factor TFIID

|full-text-url=https://sci-hub.do/10.1016/j.bbrc.2012.07.081
}}