Редактирование: SULT1B1 (раздел)

==Publications==

{{medline-entry
|title=Postnatal ontogeny and hormonal regulation of sulfotransferase [[SULT1B1]] in male and female rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/10381794
|abstract=The ontogenic and hormonal regulation of a sulfotransferase, [[SULT1B1]], was examined. Hepatic RNA was isolated from rats of various ages from 1 to 90 days. The mRNA for [[SULT1B1]] is low for both sexes until a dramatic increase ( approximately 6-fold) occurs between 15 and 30 days of age in male rats. [[SULT1B1]] expression then decreases to half of the maximal level by 90 days of age. The increase in [[SULT1B1]] mRNA in female rats is less dramatic and occurs between 30 and 45 days of age. [[SULT1B1]] mRNA expression plateaus from 45 to 90 days in female rats. Expression of [[SULT1B1]] mRNA is comparable in adult male and female rats. RNA was isolated from hypophysectomized (HX) animals and HX animals treated with growth hormone [by either male (injection) or female (infusion) pattern], estradiol, progesterone, or testosterone. HX and HX plus growth hormone, or HX plus steroid replacement, did not alter [[SULT1B1]] mRNA expression. Pituitary-intact rats were treated with steroidal compounds dexamethasone (DEX) and pregnenolone-16alpha-carbonitrile (PCN). Both DEX and PCN increased expression of [[SULT1B1]] mRNA in male rats (4- and 3-fold, respectively). However, in female rats, only PCN induced [[SULT1B1]] mRNA (2-fold), whereas DEX did not induce [[SULT1B1]] in female rats. Analysis of [[SULT1B1]] protein expression indicated that only when [[SULT1B1]] mRNA was markedly increased, that is in DEX-treated male rats, was [[SULT1B1]] protein increased. Thus, although adult male and female rats have similar [[SULT1B1]] mRNA expressions, the patterns develop ontogenically differently. [[SULT1B1]] is not regulated by pituitary hormones and DEX induces [[SULT1B1]] protein in male rats.
|mesh-terms=* Aging
* Animals
* Animals, Newborn
* Antibody Specificity
* Blotting, Northern
* Blotting, Western
* Dexamethasone
* Enzyme-Linked Immunosorbent Assay
* Female
* Glucocorticoids
* Hormones
* Hypophysectomy
* Male
* Organ Specificity
* Pregnenolone Carbonitrile
* RNA, Messenger
* Rabbits
* Rats
* Rats, Sprague-Dawley
* Sulfotransferases


}}