Редактирование: SULT1A1 (раздел)

==Publications==

{{medline-entry
|title=Bayesian association scan reveals loci associated with human lifespan and linked biomarkers.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28748955
|abstract=The enormous variation in human lifespan is in part due to a myriad of sequence variants, only a few of which have been revealed to date. Since many life-shortening events are related to diseases, we developed a Mendelian randomization-based method combining 58 disease-related GWA studies to derive longevity priors for all HapMap SNPs. A Bayesian association scan, informed by these priors, for parental age of death in the UK Biobank study (n=116,279) revealed 16 independent SNPs with significant Bayes factor at a 5% false discovery rate (FDR). Eleven of them replicate (5% FDR) in five independent longevity studies combined; all but three are depleted of the life-shortening alleles in older Biobank participants. Further analysis revealed that brain expression levels of nearby genes ([[RBM6]], [[SULT1A1]] and CHRNA5) might be causally implicated in longevity. Gene expression and caloric restriction experiments in model organisms confirm the conserved role for [[RBM6]] and [[SULT1A1]] in modulating lifespan.
|mesh-terms=* Aged
* Aged, 80 and over
* Arylsulfotransferase
* Bayes Theorem
* Biomarkers
* Disease
* European Continental Ancestry Group
* Female
* Genome-Wide Association Study
* Humans
* Longevity
* Male
* Nerve Tissue Proteins
* Polymorphism, Single Nucleotide
* RNA-Binding Proteins
* Receptors, Nicotinic
* United Kingdom

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537485
}}