Редактирование: SPTBN1 (раздел)

==Publications==

{{medline-entry
|title=The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22798246
|abstract=To investigate the effects of genetic and non-genetic factors on bone mineral densities (BMDs) and osteoporotic fractures. This was a cross-sectional study to investigate the relationships between 18 SNPs and non-genetic factors with BMDs and osteoporotic fractures in 1012 Chinese Han women. Five SNPs in genes GPR177, [[CTNNB1]], [[MEF2C]], [[SOX6]], and [[TNFRSF11B]] were associated with L1-4 or total hip BMDs. rs11898505 in [[SPTBN1]] gene was associated with osteoporotic fractures. Subjects carrying the largest number of risk alleles (highest 10 %) not only had lower BMD values as compared to those carrying the least number of risk alleles (lowest 10 %), they also had a higher risk of fracture [P = 0.002, OR = 2.252, 95 %CI (1.136, 4.463)]. Results from multivariate stepwise regression analysis revealed that age [P < 0.001, OR = 1.038, 95 % CI (1.018, 1.058)], number of falls in a year [P < 0.001, OR = 2.347, 95 % CI (1.459, 3.774)], the G risk allele in rs11898505 [P = 0.023, OR = 1.559, 95 % CI (1.062, 2.290)], and the L1-4 BMD [P = 0.017, OR = 0.286, 95 % CI (0.102, 0.798)] were associated with the occurrence of osteoporotic fractures. Genetic (rs11898505) and non-genetic factors (age, number of falls in a year and L1-4 BMD) could work in concert to contribute to the risk of osteoporotic fractures.
|mesh-terms=* Accidental Falls
* Adult
* Aged
* Aging
* Asian Continental Ancestry Group
* Bone Density
* China
* Cohort Studies
* Cross-Sectional Studies
* Female
* Genetic Association Studies
* Hip Joint
* Humans
* Lumbar Vertebrae
* MADS Domain Proteins
* MEF2 Transcription Factors
* Middle Aged
* Myogenic Regulatory Factors
* Osteoporosis, Postmenopausal
* Osteoporotic Fractures
* Osteoprotegerin
* Polymorphism, Single Nucleotide
* Radiography
* Spectrin
* Young Adult

|full-text-url=https://sci-hub.do/10.1007/s12020-012-9726-8
}}