Редактирование: SLCO1B3 (раздел)

==Publications==

{{medline-entry
|title=Paclitaxel-induced sensory peripheral neuropathy is associated with an [[ABCB1]] single nucleotide polymorphism and older age in Japanese.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28447211
|abstract=Whether age and inter-individual variability of pharmacogenetics are risk factors for paclitaxel-induced peripheral neuropathy (PIPN) is inconclusive. This study was conducted to evaluate the influence of previously investigated single nucleotide polymorphisms (SNPs) and age, using genotype data from a prospective study of paclitaxel-related toxicity in Japanese patients with breast cancer. Peripheral blood mononuclear cells from 127 Japanese women with breast cancer who received weekly adjuvant paclitaxel were used to genotypes [[SLCO1B3]] T334G (rs4149117), [[CYP2C8]] A1196G (rs10509681), [[ABCB1]] C1236T (rs1128503), [[ABCB1]] G2677T/A (rs2032582), and [[ABCB1]] C3435T (rs1045642). Genotypic and clinical factors were investigated for associations with PIPN. Of the five SNPs evaluated, no SNPs were significantly associated with grade 2 or higher PIPN. However, [[ABCB1]] 1236 TT showed a trend to associate with grade 2 or higher PIPN compared to [[ABCB1]] CT/CC (odds ratio 2.1, 95% CI 0.991-4.548, p = 0.051). In subgroup analysis, patients ≥60 years old with an [[ABCB1]] 1236 TT had a higher incidence of ≥grade 2 PIPN compared to patients with CT or CC genotype (p = 0.027). On multivariable analysis, age ≥60 years and the [[ABCB1]] 1236 TT showed a significant association with ≥grade 2 PIPN (p = 0.005 and p = 0.034, respectively). [[ABCB1]] 1236 TT genotype and older age might be a predictor of PIPN, which diminishes quality of life of cancer survivors.
|mesh-terms=* ATP Binding Cassette Transporter, Subfamily B
* Adult
* Aged
* Aging
* Antineoplastic Agents, Phytogenic
* Asian Continental Ancestry Group
* Breast Neoplasms
* Cytochrome P-450 CYP2C8
* Female
* Genotype
* Humans
* Incidence
* Middle Aged
* Organic Anion Transporters, Sodium-Independent
* Paclitaxel
* Peripheral Nervous System Diseases
* Pharmacogenetics
* Polymorphism, Single Nucleotide
* Predictive Value of Tests
* Prospective Studies
* Sensory Receptor Cells
* Solute Carrier Organic Anion Transporter Family Member 1B3
|keywords=* ABCB1
* CYP2C8
* Older age
* Paclitaxel-induced peripheral neuropathy
* SLCO1B3
|full-text-url=https://sci-hub.do/10.1007/s00280-017-3314-9
}}