Редактирование: SH3GL2 (раздел)

==Publications==

{{medline-entry
|title=Polymorphisms  associated with egg number at 300 days of age in chickens.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22002122
|abstract=We looked for variations that could be  associated with chicken egg number at 300 days of age (EN300) in seven genes of  the hypothalamic-pituitary-gonadal axis, including gonadotrophin-releasing  hormone-I (GnRH-I), GnRH receptor (GnRHR), neuropeptide Y (NPY),  dopamine D2 receptor ([[DRD2]]), vasoactive intestinal polypeptide ([[VIP]]),  [[VIP]] receptor-1 ([[VIP]]R-1), prolactin (PRL), and the QTL region  between 87 and 105 cM of the Z chromosome. Ten mutations in the seven genes  were chosen to do marker-trait association analyses in a population comprising  1310 chickens, which were obtained from a company located in Guangdong Province  of China. The C1704887T of [[VIP]]R-1 was found to have a highly significant  association with EN300. The T5841629C of [[DRD2]] and the C1715301T of [[VIP]]R-1 were significantly associated with EN300. A highly significant association  was also found between the C1704887T-C1715301T haplotypes of [[VIP]]R-1 and  EN300. H1H3 had the highest EN300. Four PCR-RFLP variations in the candidate  QTL region were selected to investigate their genetic effects on EN300. The  haplotypes of T32742468C-G32742603A in this region showed a highly significant  association with EN300. Bioinformatics analyses showed that both T32742468C  and G32742603A were located in intron 1 of the SH3-domain [[GRB2]]-like 2 ([[SH3GL2]])  gene. We conclude that five SNPs, including C1704887T and C1715301T of [[VIP]]R-1,  T5841629C of [[DRD2]], and T32742468C and G32742603A of [[SH3GL2]], would  be useful as markers for breeding to increase chicken EN300.
|mesh-terms=* Aging
* Animals
* Chickens
* Female
* Hypothalamo-Hypophyseal System
* Neuropeptide Y
* Ovum
* Polymorphism, Genetic
* Prolactin
* Receptors, Dopamine D2
* Receptors, LHRH
* Receptors, Vasoactive Intestinal Polypeptide, Type I
* Sex Chromosomes
* Vasoactive Intestinal Peptide

|full-text-url=https://sci-hub.do/10.4238/2011.October.3.5
}}