Редактирование: SFTPD (раздел)

==Publications==

{{medline-entry
|title=Polymorphisms in surfactant protein-D are associated with chronic obstructive pulmonary disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/20448057
|abstract=Chronic obstructive pulmonary disease (COPD) is characterized by alveolar destruction and abnormal inflammatory responses to noxious stimuli. Surfactant protein-D ([[SFTPD]]) is immunomodulatory and essential to host defense. We hypothesized that polymorphisms in [[SFTPD]] could influence the susceptibility to COPD. We genotyped six single-nucleotide polymorphisms (SNPs) in surfactant protein D in 389 patients with COPD in the National Emphysema Treatment Trial (NETT) and 472 smoking control subjects from the Normative Aging Study (NAS). Case-control association analysis was performed using Cochran-Armitage trend tests and multivariate logistic regression. The replication of significant associations was attempted in the Boston Early-Onset COPD Study, the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Study, and the Bergen Cohort. We also correlated [[SFTPD]] genotypes with serum concentrations of surfactant protein-D (SP-D) in the ECLIPSE Study. In the NETT-NAS case-control analysis, four [[SFTPD]] SNPs were associated with susceptibility to COPD: rs2245121 (P = 0.01), rs911887 (P = 0.006), rs6413520 (P = 0.004), and rs721917 (P = 0.006). In the family-based analysis of the Boston Early-Onset COPD Study, rs911887 was associated with prebronchodilator and postbronchodilator FEV(1) (P = 0.003 and P = 0.02, respectively). An intronic SNP in [[SFTPD]], rs7078012, was associated with COPD in the ECLIPSE Study and the Bergen Cohort. Multiple [[SFTPD]] SNPs were associated with serum SP-D concentrations in the ECLIPSE Study. We demonstrated an association of polymorphisms in [[SFTPD]] with COPD in multiple populations. We demonstrated a correlation between [[SFTPD]] SNPs and SP-D protein concentrations. The SNPs associated with COPD and SP-D concentrations differed, suggesting distinct genetic influences on susceptibility to COPD and SP-D concentrations.
|mesh-terms=* Aged
* Aging
* Case-Control Studies
* Cohort Studies
* Female
* Genetic Predisposition to Disease
* Genotype
* Humans
* Inflammation
* Longitudinal Studies
* Male
* Middle Aged
* Polymorphism, Genetic
* Polymorphism, Single Nucleotide
* Prospective Studies
* Pulmonary Disease, Chronic Obstructive
* Pulmonary Surfactant-Associated Protein D

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095932
}}