Редактирование: SCP2 (раздел)

==Publications==

{{medline-entry
|title=Deficiencies in sex-regulated expression and levels of two hepatic sterol carrier proteins in a murine model of Niemann-Pick type C disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/1639819
|abstract=Hepatic sterol carrier protein-2 ([[SCP2]]) and sterol carrier protein-X (SCPx) levels in normal and in mutant Niemann-Pick Type C mice were determined by immunoblotting with antiserum against rat [[SCP2]]. A 14-kDa protein ([[SCP2]]) was detected in the cytosol fraction and a 58-kDa protein (SCPx) was found in both cytosolic and organellar fractions. Expression of hepatic SCPx protein was developmentally regulated in a sex-specific pattern. The amounts of organelle-associated SCPx increased 4-fold during sexual development of normal males but decreased dramatically during development of normal females. Levels of hepatic [[SCP2]] increased much less dramatically during sexual maturation of normal males and females. Adult Niemann-Pick Type C mice were deficient in both hepatic SCPx and [[SCP2]]. The deficit in SCPx in affected males reflected a failure to increase hepatic SCPx levels during sexual maturation. In affected males SCPx remained at levels found in immature mice. Affected male and female mice were also unable to maintain levels of hepatic [[SCP2]]. The level of [[SCP2]] was near normal in affected immature males and subnormal in affected immature females. During sexual maturation hepatic [[SCP2]] declined in affected animals.
|mesh-terms=* Aging
* Animals
* Carrier Proteins
* Catalase
* Cytosol
* Female
* Gene Expression Regulation
* Liver
* Male
* Mice
* Mice, Inbred BALB C
* Molecular Weight
* Niemann-Pick Diseases
* Organelles
* Plant Proteins
* Sex Characteristics
* Sterols


}}