Редактирование: S100P (раздел)

==Publications==

{{medline-entry
|title=Cancer-associated [[S100P]] protein binds and inactivates p53, permits therapy-induced senescence and supports chemoresistance.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26967060
|abstract=[[S100P]] belongs to the S100 family of calcium-binding proteins regulating diverse cellular processes. Certain S100 family members (S100A4 and S100B) are associated with cancer and used as biomarkers of metastatic phenotype. Also [[S100P]] is abnormally expressed in tumors and implicated in migration-invasion, survival, and response to therapy. Here we show that [[S100P]] binds the tumor suppressor protein p53 as well as its negative regulator HDM2, and that this interaction perturbs the p53-HDM2 binding and increases the p53 level. Paradoxically, the [[S100P]]-induced p53 is unable to activate its transcriptional targets hdm2, p21WAF, and bax following the DNA damage. This appears to be related to reduced phosphorylation of serine residues in both N-terminal and C-terminal regions of the p53 molecule. Furthermore, the [[S100P]] expression results in lower levels of pro-apoptotic proteins, in reduced cell death response to cytotoxic treatments, followed by stimulation of therapy-induced senescence and increased clonogenic survival. Conversely, the [[S100P]] silencing suppresses the ability of cancer cells to survive the DNA damage and form colonies. Thus, we propose that the oncogenic role of [[S100P]] involves binding and inactivation of p53, which leads to aberrant DNA damage responses linked with senescence and escape to proliferation. Thereby, the [[S100P]] protein may contribute to the outgrowth of aggressive tumor cells resistant to cytotoxic therapy and promote cancer progression. 
|mesh-terms=* Calcium-Binding Proteins
* Cell Line, Tumor
* Cellular Senescence
* Drug Resistance, Neoplasm
* Humans
* Neoplasm Proteins
* Proto-Oncogene Proteins c-mdm2
* Tumor Suppressor Protein p53
|keywords=* HDM2
* S100P calcium-binding protein
* cell death
* p53 tumor suppressor
* therapy-induced senescence
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008377
}}