Редактирование: RGS1 (раздел)

==Publications==

{{medline-entry
|title=Increased baclofen-stimulated G protein coupling and deactivation in rat brain cortex during development.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/15246693
|abstract=The number and affinity of GABA(B) receptors (assayed by the specific antagonist [(3)H]CGP54626A) was unchanged when compared in carefully washed cerebrocortical membranes from young (12-day-old) and adult (90-day-old) rats. In contrast, high-affinity GTPase activity, both basal and baclofen-stimulated was significantly higher (by 45% and 56%, respectively) in adult than in young rats. Similar results were obtained by concomitant determination of agonist (baclofen)-stimulated GTP gamma S binding. Under standard conditions, baclofen-stimulated GTPase activity was further considerably enhanced by exogenously added regulator of G protein function, [[RGS1]], but not by [[RGS1]]6. [[RGS1]]6 was able to affect agonist-stimulated GTPase activity only in the presence of markedly increase substrate (GTP) concentrations. [[RGS1]] alone slightly increased GTPase activity in adult rats, but neither [[RGS1]] nor [[RGS1]]6 influenced GTPase activity in membrane preparations isolated from young animals. These findings indicate increasing functional activity of trimeric G protein(s) involved in GABAergic transmission in the developing rat brain cortex and suggest a high potential of [[RGS1]] in regulation of high-affinity GTPase activity.
|mesh-terms=* Aging
* Analysis of Variance
* Animals
* Animals, Newborn
* Baclofen
* Cerebral Cortex
* Dose-Response Relationship, Drug
* Drug Interactions
* GABA Agonists
* GTP Phosphohydrolases
* GTP-Binding Proteins
* Guanosine 5'-O-(3-Thiotriphosphate)
* Male
* Organophosphorus Compounds
* Protein Binding
* Proteins
* RGS Proteins
* Radioligand Assay
* Rats
* Tritium

|full-text-url=https://sci-hub.do/10.1016/j.devbrainres.2004.03.014
}}