Редактирование: RDH12 (раздел)

==Publications==

{{medline-entry
|title=Retinol dehydrogenases [[RDH11]] and [[RDH12]] in the mouse retina: expression levels during development and regulation by oxidative stress.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/18326732
|abstract=[[RDH11]] and [[RDH12]] are closely related retinol dehydrogenases expressed in the retina. [[RDH12]] has been linked to the early-onset retinal dystrophy Leber congenital amaurosis, whereas [[RDH11]] has not been associated with human disease. To understand their physiological roles, the authors investigated their expression during development and their regulation by light-induced oxidative stress in mouse retina. Quantitative RT-PCR and immunoblot analysis were used for quantification of [[RDH11]] and [[RDH12]] during development and oxidative stress. Expression during development was measured between embryonic day (E) 12 and postnatal day (P) 210 (7 months) in C57BL/6 mouse eyes. Expression during light-induced oxidative stress was measured between 2 and 24 hours of exposure to light in BALB/c mouse retina. The [[RDH11]] level was low and remarkably constant during development and oxidative stress. [[RDH12]] expression started at P7 and increased until P30 to approximately sevenfold higher than [[RDH11]]. Oxidative stress induced by exposure to constant bright light led to a rapid and significant decrease of [[RDH12]] protein. The low and constant expression of [[RDH11]] suggested a housekeeping function for this enzyme. The onset of [[RDH12]] expression during the maturation of photoreceptor cells suggested a function related to the visual process. The light-induced rapid decrease of [[RDH12]] protein, preceding the decrease of the mRNA, suggested a specific degradation of the protein rather than a regulation of gene expression.
|mesh-terms=* Aging
* Alcohol Oxidoreductases
* Animals
* Gene Expression Regulation, Developmental
* Immunoblotting
* In Situ Hybridization
* Light
* Mice
* Mice, Inbred BALB C
* Mice, Inbred C57BL
* Mice, Knockout
* Oxidative Stress
* Oxidoreductases
* RNA, Messenger
* Radiation Injuries, Experimental
* Retina
* Retinal Degeneration
* Retinal Dehydrogenase
* Reverse Transcriptase Polymerase Chain Reaction
* Transcription, Genetic

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366097
}}