Редактирование: PROS1 (раздел)

==Publications==

{{medline-entry
|title=[[PROC]], [[PROC]]R and [[PROS1]] polymorphisms, plasma anticoagulant phenotypes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health Study.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/18680534
|abstract=Genes encoding protein C anticoagulant pathways are candidates for atherothrombotic and other aging-related disorders. Using a tagSNP approach, and data from the Cardiovascular Health Study (CHS), we assessed associations of common polymorphisms of [[PROC]], [[PROS1]] and [[PROC]]R with: (i) plasma protein C, soluble protein C endothelial receptor (sEPCR) and protein S levels measured in a subsample of 336 participants at study entry; and (ii) risk of incident clinical outcomes [coronary heart disease (CHD), stroke, and mortality] in 4547 participants during follow-up. Secondarily, we explored associations between plasma protein C, protein S and sEPCR levels and other candidate genes involved in thrombosis, inflammation, and aging. The [[PROC]]R Ser219Gly polymorphism (rs867186) was strongly associated with higher sEPCR levels, explaining 75% of the phenotypic variation. The [[PROC]]R Ser219Gly variant was also associated with higher levels of circulating protein C antigen. An [[IL10]] polymorphism was associated with higher free protein S levels. The minor alleles of [[PROC]] rs2069901 and [[PROS1]] rs4857343 were weakly associated with lower protein C and free protein S levels, respectively. There was no association between [[PROC]]R Ser219Gly and risk of CHD, stroke, or mortality. The minor allele of another common [[PROC]]R tagSNP, rs2069948, was associated with lymphoid [[PROC]]R mRNA expression and with increased risk of incident stroke and all-cause mortality, and decreased healthy survival during follow-up. A common [[PROC]]R variant may be associated with decreased healthy survival in older adults. Additional studies are warranted to establish the role of [[PROC]]R variants in ischemic and aging-related disorders.
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Antigens, CD
* Blood Coagulation Factor Inhibitors
* Cardiovascular Diseases
* Coronary Disease
* Endothelial Protein C Receptor
* Female
* Humans
* Inflammation
* Male
* Middle Aged
* Mortality
* Polymorphism, Genetic
* Protein C
* Protein S
* Receptors, Cell Surface
* Risk
* Stroke
* Thrombosis

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856703
}}