Редактирование: PPP2R5C (раздел)

==Publications==

{{medline-entry
|title=PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/20444422
|abstract=The insulin/TOR signaling pathway plays a crucial role in animal homeostasis, sensing nutrient status to regulate organismal growth and metabolism. We identify here the Drosophila B' regulatory subunit of PP2A (PP2A-B') as a novel, conserved component of the insulin pathway that specifically targets the PP2A holoenzyme to dephosphorylate S6K. PP2A-B' knockout flies have elevated S6K phosphorylation and exhibit phenotypes typical of elevated insulin signaling such as reduced total body triglycerides and reduced longevity. We show that PP2A-B' interacts with S6K both physically and genetically. The human homolog of PP2A-B', [[PPP2R5C]], also counteracts S6K1 phosphorylation, indicating a conserved mechanism in mammals. Since S6K affects development of cancer and metabolic disease, our data identify [[PPP2R5C]] as a novel factor of potential medical relevance.
|mesh-terms=* Animals
* Drosophila
* Drosophila Proteins
* Gene Knockout Techniques
* Humans
* Insulin
* Longevity
* Phosphoprotein Phosphatases
* Phosphorylation
* Protein Phosphatase 2
* Ribosomal Protein S6 Kinases, 70-kDa
* Signal Transduction
* Triglycerides

|full-text-url=https://sci-hub.do/10.1016/j.cmet.2010.03.015
}}