Редактирование: PPP2R2B (раздел)

==Publications==

{{medline-entry
|title=Germline genetics of the p53 pathway affect longevity in a gender specific manner.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24654968
|abstract=Aging is thought to occur through the accumulation of molecular and cellular damage. A key regulator of the cell's stress response is p53. In mice, the activity of p53 associates with lifespan. We were therefore interested whether SNPs in members of the p53-pathway are associated with longevity in humans. We genotyped the following SNPs: p53 - rs1042522 (Arg72Pro), [[MDM2]] - rs2279744 (SNP309), [[MDM4]] - rs4245739 (SNP34091), rs1563828 (SNP31826), [[PPP2R2B]] (rs319217) in 155 long-lived individuals (LLIs) who died at the age of 91 and over and in 171 ethnically-matched control subjects. Kaplan-Meier survival curves and log-Rank-test were used to determine the mean and median survival times. In female LLIs, the Pro-allele of rs1042522 (Arg72Pro) and the G-allele of rs2279744 (SNP309) were significantly associated with an increased survival time (P=0.026, P<0.001, respectively, log-Rank-test). In contrast, there was no difference regarding the survival time in male LLIs (rs1042522: P=0.58, rs2279744: P=0.503, log-Rank-test). There was no difference regarding the average age of death for the genotypes of the respective SNPs in the [[MDM4]] gene (rs1563828: P=0.99; rs4245739: P=0.179, respectively). Here we show for the first time that the G-allele of rs2279744 (SNP309) is associated with increased lifespan. Importantly, this effect is gender-specific. Our data support the hypothesis that genetic variants that are associated with lower activity of p53--and therefore increased tumor risk--are associated with prolonged lifespan in a gender-specific manner.
|mesh-terms=* Age Factors
* Aged, 80 and over
* Case-Control Studies
* Cell Cycle Proteins
* Female
* Gene Frequency
* Genotype
* Humans
* Kaplan-Meier Estimate
* Longevity
* Male
* Nerve Tissue Proteins
* Nuclear Proteins
* Phenotype
* Polymorphism, Single Nucleotide
* Protein Phosphatase 2
* Proto-Oncogene Proteins
* Proto-Oncogene Proteins c-mdm2
* Sex Factors
* Signal Transduction
* Time Factors
* Tumor Suppressor Protein p53

|full-text-url=https://sci-hub.do/10.2174/1874609807666140321150751
}}